ライフサイエンスコーパス: controlled cortical impact

1 jury time points in a preclinical TBI model (controlled cortical impact).

2 ered to tail pinch, and TBI was delivered by controlled cortical impact.

3 oblotting within mouse parietal cortex after controlled cortical impact.

4 ely-moving rats at 14 days following lateral controlled cortical impact.

5 Rats were subjected to TBI by pneumatic controlled cortical impact.

6 ve, sham-operated, TBI) underwent a moderate controlled cortical impact.

7 eatment following mechanical brain lesion by controlled cortical impact.

8 on is associated with reduced sequelae after controlled cortical impact.

9 Mechanical brain lesion by controlled cortical impact.

10 treatment with candesartan for 5 days after controlled cortical impact.

11 ) and traumatic brain injury (TBI) caused by controlled cortical impact.

12 ced in adult EPOR-null and wild-type mice by controlled cortical impact.

13 perimental traumatic brain injury induced by controlled cortical impact and (2) to evaluate whether m

14 /6J mice (weight, 21-26 g) were injured with controlled cortical impact and divided into 2 groups (n=

15 subjected to sham surgery or moderate-level controlled cortical impact and infected intranasally wit

16 experimental traumatic brain injury (TBI) by controlled cortical impact and investigated cortical spr

17 Adult male Wistar rats were injured with controlled cortical impact and treated either with salin

18 erimental TBI in C57BL/6 mice was induced by controlled cortical impact, and (64)Cu uptake in the inj

19 Using controlled cortical impact as a model of traumatic brain

20 At the time of controlled cortical impact, body weight, brain and body

21 function and histopathologic sequelae after controlled cortical impact brain injury were evaluated i

22 In the controlled cortical impact (CCI) animal model of pediatr

23 Following controlled cortical impact (CCI) at 0.5 mm depth to the

24 havioral and histopathological outcome after controlled cortical impact (CCI) brain injury in mice de

25 chromosome (YAC), we examined the effects of controlled cortical impact (CCI) brain injury on neuromo

26 ution within the hippocampus also occur post controlled cortical impact (CCI) demonstrating a reducti

27 d 7 months after unilateral mild-to-moderate controlled cortical impact (CCI) in 5-7-month-old Tg/hta

28 Severe TBI was produced using controlled cortical impact (CCI) in a rat model, and TNS

29 changes during the first several days after controlled cortical impact (CCI) in mice.

30 s on neuronal and network excitability after controlled cortical impact (CCI) in mice.

31 ucted a temporal analysis of the response to controlled cortical impact (CCI) in rat microglia betwee

32 xpression of neuroinflammatory markers after controlled cortical impact (CCI) induced experimental TB

33 (n=35) Sprague-Dawley rats underwent either controlled cortical impact (CCI) injury (2.7 mm; 4 m/s)

34 P donor mice and subjected the recipients to controlled cortical impact (CCI) injury 14 days post-tra

35 d that hippocampal synaptic damage caused by controlled cortical impact (CCI) injury in mice results

36 -Dawley rats were subjected to TBI using the controlled cortical impact (CCI) injury model.

37 his hypothesis, we used Nlrx1(-/-) mice in a controlled cortical impact (CCI) injury murine model of

38 We therefore performed controlled cortical impact (CCI) injury on mice to inves

39 However, the effect of controlled cortical impact (CCI) injury on TH in the nig

40 on was investigated by microarray 24 h after controlled cortical impact (CCI) injury or sham injury i

41 ere anesthetized and surgically prepared for controlled cortical impact (CCI) injury or sham surgery.

42 Histopathological changes at 7 days after controlled cortical impact (CCI) injury were examined.

43 We subjected adult mice to controlled cortical impact (CCI) injury, and isolated RN

44 unctional and histological outcome following controlled cortical impact (CCI) injury.

45 n and cerebral blood flow recovery following controlled cortical impact (CCI) injury.

46 ronal injury in a rodent model of unilateral controlled cortical impact (CCI) injury.

47 The controlled cortical impact (CCI) model is one of the mos

48 In this study, using a controlled cortical impact (CCI) model of head injury, w

49 Using a murine controlled cortical impact (CCI) model of TBI, we invest

50 nt excitation in the dentate gyrus using the controlled cortical impact (CCI) model of TBI.

51 ive and migratory response of the brain to a controlled cortical impact (CCI) model of traumatic brai

52 ed PAI-1 as a possible new target in a mouse controlled cortical impact (CCI) model of traumatic brai

53 flammatory activation post-TBI using a mouse controlled cortical impact (CCI) model.

54 isms associated with OD in male mice using a controlled cortical impact (CCI) model.

55 ges of both the closed head injury (CHI) and controlled cortical impact (CCI) models, we developed a

56 Here, we utilized a controlled cortical impact (CCI) mouse model of TBI and

57 imvastatin will render maximum recovery in a controlled cortical impact (CCI) mouse model of TBI.

58 trocytes after contusion injury generated by controlled cortical impact (CCI) of different severities

59 ANC, GCSF to increase ANC, or saline before controlled cortical impact (CCI) of moderate overall sev

60 Long Evans male rats received a controlled cortical impact (CCI) over the caudal forelim

61 trophic factor (AdGDNF), one week prior to a controlled cortical impact (CCI) over the forelimb senso

62 Using a controlled cortical impact (CCI) procedure in rats, we s

63 pecific EphA4 knockout and subjected them to controlled cortical impact (CCI) to investigate the role

64 e autoradiography was performed 45 min after controlled cortical impact (CCI) to left parietal cortex

65 in rat brains up to 2 months after digitally controlled cortical impact (CCI) to produce traumatic br

66 ons in an experimental rat model of moderate controlled cortical impact (CCI) while considering diffe

67 In a model of controlled cortical impact (CCI) with secondary hypoxemi

68 Controlled cortical impact (CCI), an experimental trauma

69 wing 2 different models of experimental TBI, controlled cortical impact (CCI), and closed head injury

70 Following controlled cortical impact (CCI), bolus administrations

71 In a rat model of controlled cortical impact (CCI), we determined that ani

72 g/kg at 5 min, 6 h and 24 h; i.p.) following controlled cortical impact (CCI)-induced traumatic brain

73 4-month-old PDAPP and wild type (WT) mice by controlled cortical impact (CCI).

74 inhibition by bumetanide in a mouse model of controlled cortical impact (CCI).

75 (n = 9) and were sacrificed at 6 weeks after controlled cortical impact (CCI).

76 in serum miRNAs using two rat models of TBI (controlled cortical impact [CCI] and fluid percussion in

77 in injury (TBI) induced in adult rats with a controlled cortical impact device.

78 Brain trauma by use of a controlled cortical impact device.

79 C57BL6 mice received controlled cortical impact followed by hemorrhagic hypot

80 ical and behavioural outcomes, mice received controlled cortical impact followed by initiation of pio

81 rate traumatic brain injury (TBI) induced by controlled cortical impact in adult mice.

82 oxic neuroinflammatory loop at 1-month after controlled cortical impact in mice by pharmacological re

83 After controlled cortical impact in mice, MMP-9 was increased

84 mins, 3 hrs, 6 hrs, 12 hrs, and 24 hrs after controlled cortical impact in mice.

85 We generated controlled cortical impacts in adult rats.

86 Controlled cortical impact-induced cognitive impairment

87 AT1R knockout mice were less vulnerable to controlled cortical impact-induced injury suggesting tha

88 Both candesartan and telmisartan ameliorated controlled cortical impact-induced injury with a therape

89 f propofol (36 or 72 mg/kg/hr) either during controlled cortical impact induction or in a delayed app

90 Traumatic brain injury was produced by controlled cortical impact injury (4 m/sec, 2.6 mm of ti

91 Brain from rats (n=24) subjected to controlled cortical impact injury and sham operated (n=3

92 Controlled cortical impact injury caused immediate hyper

93 sensory-motor cortex was implemented by the controlled cortical impact injury device.

94 We used a controlled cortical impact injury model to determine the

95 ains following traumatic brain injury (TBI), controlled cortical impact injury of mild to moderate se

96 We demonstrate that controlled cortical impact injury of rats causes a long-

97 her characterize this response, we performed controlled cortical impact injury on male mice and deter

98 a TBI mouse model that received 1.8 mm deep controlled cortical impact injury or craniectomy only (c

99 ocompetent adult female rats received either controlled cortical impact injury or sham surgery.

100 Specifically, animal cohorts sustaining a controlled cortical impact injury received an intravenou

101 minutes after the induction of a unilateral controlled cortical impact injury resulted in their inco

102 ted with adeno-associated virus-Prok2 before controlled cortical impact injury show reduced neuronal

103 m mild, moderate, and severe TBI produced by controlled cortical impact injury technique.

104 als were sedated with sevoflurane during the controlled cortical impact injury, and propofol was give

105 Following TBI induced by controlled cortical impact injury, scaffold with hMSCs (

106 Using a validated mouse model of controlled cortical impact injury, we determined effecti

107 iced at 2 h, 6 h, 24 h, 72 h and 168 h after controlled cortical impact injury.

108 Mice were subjected to sham or controlled cortical impact injury.

109 8 wk old C57BL/6J mice 30 min after moderate controlled cortical impact injury.

110 IV propofol bolus application delayed after controlled cortical impact injury.

111 ale Wistar rats were subjected to unilateral controlled cortical impact injury.

112 ulated in neurons throughout the brain after controlled cortical impact injury.

113 Using a controlled cortical impact, mild and moderate injuries (

114 liosides in normal brain and the effect of a controlled cortical impact model (CCI) of traumatic brai

115 between the injured brain and lung, using a controlled cortical impact model followed by secondary S

116 N-beta in secondary injury after TBI using a controlled cortical impact model in adult male IFN-beta-

117 en Cav-1 (SynCav1 Tg)] and subjected it to a controlled cortical impact model of brain trauma and mea

118 74-days post-injury (DPI)) in mice using the controlled cortical impact model of experimental TBI.

119 man adipose-derived stem cells (hADSCs) in a controlled cortical impact model of mild TBI using young

120 temic administration of TAT-CBD3 following a controlled cortical impact model of TBI decreased hippoc

121 Using a controlled cortical impact model of TBI in male mice, si

122 al edema by increasing the AQP4 level in the controlled cortical impact model of TBI in mice.

123 s a novel therapeutic target for TBI using a controlled cortical impact model of TBI on adult male mi

124 served BBB integrity/permeability in a mouse controlled cortical impact model of TBI when studied usi

125 In the present study, we used a controlled cortical impact model of TBI with pertinent l

126 wild-type control mice were subjected to the controlled cortical impact model of TBI.

127 Mice were administered a sham surgery or the controlled cortical impact model of TBI.

128 but normal cytoprotective activity, using a controlled cortical impact model of TBI.

129 eceived sham, mild or moderate injury in the controlled cortical impact model of TBI.

130 Using a controlled cortical impact model of traumatic brain inju

131 Here, using a controlled cortical impact model of traumatic brain inju

132 er analysis, and applied the method to a rat controlled cortical impact model to identify the specifi

133 ation of posttraumatic epilepsy in the mouse controlled cortical impact model was first performed usi

134 is of rat microglia 24 h after TBI using the controlled cortical impact model, validated with a bioin

135 Using a murine controlled cortical impact model, we used adoptive trans

136 Wistar rats were subjected to TBI using the controlled cortical impact model.

137 day, 1 week, and 4 weeks after TBI using the controlled cortical impact model.

138 inetics following intravenous injection in a controlled cortical impact mouse model of TBI.

139 o facilitate behavioral recovery following a controlled cortical impact of rats.

140 rformed on rats with moderate TBI induced by controlled cortical impact on one cerebral hemisphere.

141 Male C57Bl/6 mice were subjected to severe controlled cortical impact or a sham control surgery, at

142 e head injury by lateral fluid percussion, a controlled cortical impact or impact acceleration.

143 astrointestinal dysfunction, mice received a controlled cortical impact or sham brain injury and inte

144 ubcutaneously twice per day for 7 days after controlled cortical impact or sham injury (n = 16).

145 nce, and lesion volume were determined after controlled cortical impact or sham injury.

146 Male mice received a controlled cortical impact or sham surgery at postnatal

147 Wistar rats were subjected to controlled cortical impact or sham surgery.

148 TBI was induced by controlled cortical impact over the left parietal cortex

149 TBI was induced by controlled cortical impact over the left parietal cortex

150 improved Morris water maze performance after controlled cortical impact (p < .05, repeated-measures a

151 bjected to sham or traumatic brain injury by controlled cortical impact received human amniotic mesen

152 Controlled cortical impact resulted in accumulation of o

153 olamine oxidation and improved outcome after controlled cortical impact, suggesting that 15-lipoxygen

154 In brain tissue subjacent to 1.0 mm depth controlled cortical impact, surviving hippocampal neuron

155 When subjected to a controlled cortical impact, SynCav1 Tg mice demonstrated

156 Here, we report that controlled cortical impact TBI in 3xTg-AD mice resulted

157 FGF-2(-/-) and FGF-2(+/+) mice subjected to controlled cortical impact, the number of dividing cells

158 to adult male C57BL/6J mice at 1 month after controlled cortical impact to remove chronically activat

159 , 12, 24, 48, and 96 hours; and 1 week after controlled cortical impact using anti-mouse mannose-bind

160 Controlled cortical impact was performed to the left par

161 Controlled cortical impact was used to induce traumatic

162 Controlled cortical impacts were performed experimentall

163 type 1A decreased by 42% within 24 hrs after controlled cortical impact, whereas angiotensin II recep