ライフサイエンスコーパス: controlled-release

1 st line drug gemcitabine after heat mediated controlled release.

2 ntial to ensure high quality and efficacy in controlled release.

3 ycol/poly(-caprolactone), allowing diffusion-controlled release.

4 es, proteins, small RNA molecules, and their controlled release.

5 priate therapeutic drug concentration with a controlled release.

6 l diffusion rates to give systems capable of controlled release.

7 n for correlating structure with function in controlled release.

8 iety of applications ranging from sensors to controlled release.

9 design of surface coatings in the context of controlled release.

10 recent editorial published in the Journal of Controlled Release.

11 loits a new mechanism for both formation and controlled release.

12 icles (SiO(2) NPs) have potential utility in controlled release.

13 it communities in a variety of sub-fields of Controlled Release.

14 nanocages as carriers for drug delivery and controlled release.

15 approach we previously reported (Journal of Controlled Release, 2016 a &b).

16 Journal of Controlled Release, 2019; 305, 221-222 [1].

17 romising and clinically relevant platform to controlled-release Ade and address large bone defects.

18 (416 to 1001) and three journals (Journal of Controlled Release, Advanced Drug Delivery Reviews, and

19 ly improved its stability and contributed to controlled release after consumption by modifying vitami

20 ition, we describe the use of macrophages as controlled release agents upon stimulation by physical a

21 al stimulus, allows for new opportunities in controlled release and delivery applications.

22 he effects of the biomolecular corona on the controlled release and drug delivery of nanocarriers wil

23 cies of the SMOF NP are attributed to its pH-controlled release and endosomal escape capabilities due

24 olonged circulation, reduced immunogenicity, controlled release and enhanced safety.

25 um area under the curve (AUC), demonstrating controlled release and improved serum delivery over 24 h

26 y of neurotrophin-3, which provides affinity-controlled release and longer delivery time compared to

27 art nanosystems used in biosensing, imaging, controlled release and other applications.

28 irmed the suitability of MSPs as support for controlled release and protection of bioactive molecules

29 viding the possibility of a spatiotemporally controlled release and protection of bound biomolecules.

30 dil is a feasible option for a non-invasive, controlled release and pulmonary preferential treatment

31 CMs in the context of desired properties for controlled release and related applications is provided.

32 s and hence present unique opportunities for controlled-release and tissue-engineering applications.

33 ility to attach multiple targeting moieties, controlled release, and site-specific targeting.

34 roposed material has high thermal stability, controlled release, and water absorption capacity.

35 ping single-administration vaccines based on controlled-release antigen delivery systems.

36 ial as materials for nanoscale transport and controlled release applications.

37 th different drugs has been investigated for controlled release applications.

38 Finally, novel approaches to controlled release are described, including devices that

39 in, where physiological mechanisms impacting controlled release are incorporated to capture observed

40 he constitutively expressed ANAC017, and its controlled release, are crucial to fine-tune a fast reac

41 tion of ORP under gastric conditions and its controlled release at intestinal conditions, and higher

42 ith enhancement in their bioavailability and controlled release at the target site.

43 lso enhance biomolecules bioavailability and controlled release, at the same time that improve the pr

44 s used as gates, the opening mechanisms, and controlled release behavior are detailed.

45 solid-shelled microcapsules having precisely controlled release behavior is described.

46 of detecting pellet-to-pellet variations in controlled release behavior.

47 ne based-approach comprised of two synthetic controlled-release biomaterials, poly(lactide-co-glycoli

48 ered topically for prolonged periods through controlled release by specifically designed alginate ban

49 d code, to receive lacosamide monotherapy or controlled-release carbamazepine (carbamazepine-CR) twic

50 ng, but highly desirable for applications in controlled release, catalysis, and sensing.

51 anti-inflammatory efficacy likely due to the controlled release compared to free 6-S in a dextran sul

52 sing, good colonic absorption and a reliable controlled release (CR) technology are necessary.

53 n with an extended-release formulation (HCTZ-controlled release [CR]) was added.

54 The rate of affinity-controlled release depends on the polymer concentrations

55 ncepts in the development of injectable PLGA controlled-release depots for peptides and proteins, and

56 An important poorly understood phenomenon in controlled-release depots involves the strong interactio

57 unlike the diffusion based unloading of most controlled release devices for small molecules.

58 cial development in the area of this complex controlled release dosage form.

59 technical challenges when developing an oral controlled release dosage form.

60 ars, there have been significant advances in controlled release dosage forms used for contraception.

61 PLGA microspheres are widely studied for controlled release drug delivery applications, and many

62 pment and translation of clinically-relevant controlled release drug delivery systems.

63 elivery routes, less-frequent dosing through controlled-release drug delivery and improved drug targe

64 itro release studies of CEO-ChNPs revealed a controlled release during 56 days.

65 ry systems with retained lactase in milk and controlled release during in vitro digestion.

66 and negatively charged drugs, as well as the controlled release effect.

67 n with directly adding CaO2 due to the OH(-) controlled-release effect of OCRMs.

68 ellbore leakage in the vadose zone through a controlled release experiment and demonstrate that fugit

69 Controlled release experiments showed an initial burst f

70 After testing in several controlled release experiments, the system was deployed

71 Controlled-release fertilizers (CRFs) can change the rel

72 and simulations techniques used for coated, controlled-release fertilizers.

73 The controlled release FGF2 additive reduces the frequency o

74 lating complex multidrug administration from controlled release films for localized delivery remains

75 an historical overview of drug delivery and controlled release followed by highlights of four emergi

76 bic and hydrophilic drugs and are capable of controlled release for a prolonged period of time.

77 ability against harsh conditions and provide controlled release for food/pharmaceutical applications.

78 illustrates an effective platform to produce controlled release formulation of anti-cancer drugs, and

79 biocompatible, biodegradable, and non-toxic controlled release formulation of ATRA for effective HCC

80 erates healing of cutaneous wounds only as a controlled release formulation.

81 drug delivery systems have produced numerous controlled release formulations helping patients improve

82 parameters were evaluated to prepare 1-month controlled release formulations with a similar compositi

83 yl cellulose film coatings in pharmaceutical controlled release formulations.

84 the factors that contribute to the slow and controlled release from each class of particle, as well

85 chieved after the cooking process, where the controlled release function of the microcapsules was cle

86 in an indigenously prepared, biodegradable, controlled-release gel as an adjunct to scaling and root

87 in an indigenously prepared, biodegradable, controlled-release gel, as an adjunct to scaling and roo

88 The field of controlled release has contributed significantly to fema

89 Light-controlled release has gained popularity in recent years

90 device design that gives rise to the desired controlled release has yet to be defined.

91 s article presents a comprehensive review on controlled release hormonal contraceptive systems that i

92 ersity of chemical modifications, stability, controlled release, however limited drug loading capacit

93 Such controlled release hydrolysable polymers with very high

94 e encapsulated by various wall materials for controlled release in food and digestion systems.

95 tages, providing an improved opportunity for controlled release in higher-stage patients.

96 tent of catechin in intestinal juice ensured controlled release in intestine.

97 s found for SDE microcapsules, while erosion-controlled release in simulated gastric and intestinal f

98 es in the endoplasmic reticulum (followed by controlled release in the Golgi) are unclear.

99 Diffusion-controlled release in the simulated gastric fluid was fo

100 s and synthetic polymers for the purposes of controlled release in tissue engineering.

101 h microsphere formulations exhibited erosion-controlled release in vitro, indicated by similar polyme

102 using their own cameras and protocols, with controlled releases in an 8-acre outdoor facility that c

103 potential for facile production of low-cost controlled-release injectable depots for leuprolide and

104 rated into a methylcellulose vehicle for its controlled release into intrabony defect (IBD) sites as

105 The Journal of Controlled Release (JCR) has played a pivotal role in th

106 he time of the first issue of the Journal of Controlled Release (JCR), polymeric drugs, polymer-drug

107 nd showcases the importance of tailoring the controlled release kinetics of the formulation to the ho

108 Nanoencapsulated pesticides can provide controlled release kinetics, while efficiently enhancing

109 eutics to the target site with sustained and controlled release kinetics.

110 size selective separation and purification, controlled-release materials, sensors and catalysts, sca

111 lymers (SELPs) have been effectively used as controlled release matrices for the delivery of viruses

112 nthesized material prior to application as a controlled release matrix.

113 A single 10 muM low dose of controlled release mAv-Dex (2:1:1) effectively suppresse

114 release profiles and explore the underlying controlled-release mechanisms.

115 A novel electrochemically controlled release method for nitric oxide (NO) (based o

116 examined the in-vivo efficacy of a nebulised controlled-release microparticle formulation of heparin

117 he C-C motif chemokine ligand 2 (CCL2) using controlled-release microparticles (MPs).

118 Release testing of parental controlled release microspheres is an essential step in

119 Ultimately, the combination of controlled release microspheres with a thermoresponsive

120 vivo correlations (IVIVCs) for biodegradable controlled release microspheres.

121 We examined whether a controlled-release mitochondrial protonophore (CRMP) tha

122 A controlled-release mitochondrial protonophore reverses h

123 elease oral formulation of DNP, called CRMP (controlled-release mitochondrial protonophore), that pro

124 unable molecular sieves, gated membranes and controlled-release nanocontainers.

125 erapeutics that can be self-assembled into a controlled release nanoparticle with abilities to delive

126 nmet need which calls for the development of controlled-release nanoparticle (NP) technologies to fur

127 readily encapsulated in nanoparticles, with controlled release of 89% of drug into media over three

128 d-supported catalytic system enabled locally controlled release of a fluorescent dye into the brain o

129 gical order-order transitions to achieve the controlled release of a model payload (e.g., silica nano

130 lene oxide) (PPO)-PEO poloxamers, capable of controlled release of a therapeutic recombinant adeno-as

131 ratio of Ade and PVA showed a sustained and controlled release of Ade and facilitated the osteogenic

132 here delivery system has been fabricated for controlled release of alendronate (AL).

133 active antimicrobial packaging based on the controlled release of Allyl isothiocyanate (AITC) from m

134 A controlled release of angiotensin-(1-9) is needed for it

135 By NIR laser irradiation, a controlled release of angiotensin-(1-9) was achieved fro

136 The controlled release of anti-PD1 and CpG ODN by CpG DNA-ba

137 e-5'-triphosphate (ATP) as a trigger for the controlled release of anticancer drugs.

138 in polymer, and d) provide improved in vitro controlled release of antigenic TT.

139 In this paper, the controlled release of aroma compounds from cyclodextrins

140 and that beta-CD polymers could perform the controlled release of aroma compounds.

141 delivery vehicle, it was discovered that the controlled release of autoantigen was important for the

142 late the production of lactose-free food and controlled release of beta-galactosidase into lactose-in

143 iterion to corrective therapy was the steady controlled release of beta-glu and its diffusion through

144 to verify that laser irradiation facilitated controlled release of both hydrophobic and hydrophilic d

145 nts in the Plasmodium life cycle rely on the controlled release of Ca(2)(+) from intracellular stores

146 Controlled release of CAR from PLA nanoparticles (NPs) c

147 This system facilitates easily controlled release of cargoes to achieve multi-functiona

148 es (and hydrogels) for targeted delivery and controlled release of cargoes.

149 tissue destruction, we hypothesized that the controlled release of CCL22 could also recruit Tregs to

150 erous cells has been targeted herein for the controlled release of chemotherapeutics at the tumour si

151 Controlled release of chromatin from the nuclei of infla

152 al properties and smooth surfaces and showed controlled release of CHX over a long time.

153 to target mitochondria of cells, resulted in controlled release of cisplatin from Platin-M locally in

154 The nanoparticles also provide controlled release of cisplatin in effective concentrati

155 hat, when placed into a meniscal defect, the controlled release of collagenase and PDGF-AB increases

156 inical conditions have been investigated for controlled release of contraceptive hormones.

157 bial surfaces; its mechanism is based on the controlled release of copper (I) ions (Cu(1+)) from cupr

158 Local controlled release of corticosteroids may reduce the rat

159 environment and thus offers a mechanism for controlled release of CPT.

160 ene delivery through improved protection and controlled release of DNA cargo.

161 lerated and we successfully demonstrated the controlled release of dopamine over a period of four wee

162 Controlled release of DOX molecules from GIANs is achiev

163 pecies (ROS)-responsive diselenide bonds for controlled release of doxorubicin (DOX) at tumor sites a

164 and can be further exploited to trigger the controlled release of droplet components.

165 mplexes have received much attention for the controlled release of drugs due to the remarkable abilit

166 of implantable thermosensitive gels for the controlled release of drugs for localized cancer treatme

167 s an important role in the encapsulation and controlled release of drugs from PLGA microparticles.

168 retention of vaginal gels and modulating the controlled release of drugs from the gel matrix.

169 Herein we focus on reviewing advances in controlled release of drugs from tissue engineering plat

170 release process and can be used for the time-controlled release of drugs in postoperative therapy.

171 et system (TMUPS), using coated pellets, for controlled release of drugs is an effective therapeutic

172 ble interest in recent years for temperature-controlled release of drugs.

173 The controlled release of each protein allowed them to be de

174 to their unique properties and potential for controlled release of encapsulated drugs and structure-s

175 ulation systems can positively influence the controlled release of food ingredients in food and nutri

176 cell proliferation and viability, while the controlled release of GLN from the PLGA-GLN pellet resul

177 A field study involving the controlled release of groundwater containing dissolved C

178 construct architecture during printing, and controlled release of growth factors after printing.

179 Controlled release of growth factors, cytokines, and sma

180 these results suggest that coacervate-based controlled release of HB-EGF may serve as a new therapy

181 mouse excisional full-thickness wound model, controlled release of HB-EGF within the wound significan

182 her molecular machines driven by ATP is that controlled release of hydrolysis products is essential f

183 demonstrates targeted delivery, imaging, and controlled release of hydrophobic agents.

184 tractive candidate for the encapsulation and controlled release of hydrophobic nutraceuticals and bio

185 Both nanoparticle formulations provided controlled release of I3C and DIM in PBS medium.

186 Activation of these cells leads to a tightly controlled release of inflammatory mediators stored in s

187 re we report a delivery system that provides controlled release of insulin closely mimicking physiolo

188 insulin is practically prohibited, the dose-controlled release of insulin in the entire diabetic ran

189 This platform enables the controlled release of intra-lymph-mobile small-molecular

190 ocarrier-based degradable hydrogels provided controlled release of lactic acid for several hours; how

191 degradable hydrogels were developed for the controlled release of lactic acid in the vagina of BV-in

192 copies of lactic acid per molecule provided controlled release of lactic acid with a maximum release

193 ssessment, biodistribution tracking, and the controlled release of loaded drugs.

194 Folding occurs upon controlled release of newly synthesized proteins from th

195 s, including decreased leaching of NO donor, controlled release of NO, and maintenance of ultra-low f

196 The controlled release of odontogenic exosomes resulted in a

197 To summarize, with increased solubility and controlled release of olive leaf phenolic compounds thro

198 biodegradable catalytic framework to achieve controlled release of one of the most important chemothe

199 Combined delivery of stem cells with the controlled release of osteogenic factors, within a mecha

200 llow, thermoresponsive nanoparticles for the controlled release of our anti-inflammatory MK2-inhibiti

201 Controlled release of oxygen from small organic molecule

202 ase II (Pol II) in early elongation, and the controlled release of paused polymerase into productive

203 timely activation of each device to perform controlled release of pesticides in air.

204 actic-co-glycolic acid) for the delivery and controlled release of pesticides, and could be developed

205 e results are likely of use in signaling the controlled release of pharmaceutical payloads.

206 We hypothesized that controlled release of PHCCC from degradable nanoparticle

207 merase II (Pol II) to promoters, through the controlled release of promoter-proximally paused Pol II

208 the main contributor for the observed highly controlled release of proteins that are otherwise rapidl

209 he unique protecting role of surface sulfur, controlled release of S(2-) from Tu, and formation of NC

210 nto account when formulating, more precisely controlled release of SC injected biopharmaceuticals cou

211 ber of the Rab family of GTPases that allows controlled release of secretory granules.

212 gh comparisons between model predictions and controlled release of several drugs from various-sized m

213 drug-eluting stents (DES), which impart the controlled release of sirolimus or paclitaxel from durab

214 re may also contribute to the spatiotemporal controlled release of some of its components, which part

215 Microencapsulation and controlled release of the biocontrol agent Pantoea agglo

216 suggested that nanoencapsulation provided a controlled release of the carotenoid.

217 ral droplets may result in a progressive and controlled release of the encapsulated citral.

218 e acetonide (FLUO) conjugate that allows the controlled release of the FLUO to reduce skin inflammati

219 Local, affinity-controlled release of the modified protein (PEG-N1000G-C

220 cated protein subunits to trigger the highly controlled release of the nascent RNA transcript.

221 inflammatory M1 macrophages concomitant with controlled release of the payload of anti-inflammatory d

222 of a single competitive guest results in the controlled release of the reagents, thus triggering thei

223 h, revealing their ability to participate in controlled release of their constituent nanostructures,

224 IR) has great potential for spatiotemporally controlled release of therapeutic agents, it has been ha

225 siologic barriers for efficient delivery and controlled release of therapeutics to the lungs.

226 l to trigger plant immunity and suggest that controlled release of these molecules upon infection may

227 A specialized matrix formulated for controlled release of this aggregation pheromone was dev

228 Controlled release of this unusual C1 product may suppor

229 this challenge through targeted delivery and controlled release of tissue plasminogen activator (tPA)

230 m through the simultaneous encapsulation and controlled release of two synergistic anticancer drugs u

231 By contrast, the controlled release of uranyl after capture is less estab

232 iew to developing a delivery vehicle for the controlled release of vitamin B6 over a prolonged period

233 novel delivery systems for encapsulation and controlled release of volatile allyl isothiocyanate (AIT

234 drogels were employed for immobilization and controlled released of beta-galactosidase.

235 The formulation provided controlled releases of the encapsulated therapeutic comp

236 or tissue repair that contain stem cells and controlled-release of programming factors is innovative,

237 ch issues of low bioavailability and limited controlled release opportunities are well known and have

238 tions of 3DOM materials, namely sorption and controlled release, optical and electrochemical sensors,

239 We developed a controlled-release oral formulation of DNP, called CRMP

240 nd 2) this depot platform enabled long-term, controlled release over 4weeks (92-272mug/mL of MK2i).

241 -inhibitor-polymer conjugate formulated into controlled-release particles that maximizes efficacy and

242 he decrease in the buoyant mass of the solid controlled-release pellet as it dissolves.

243 We weigh single controlled-release pellets in fluid using a vibrating tu

244 y, for drug dosage forms containing multiple controlled-release pellets, particles, beads, granules,

245 By measuring any controlled-release pellets, particles, beads, or granule

246 r obtaining dissolution profiles from single controlled-release pellets.

247 d the OCRMs with triple functions for oxygen controlled-release, phosphorus removal and less impact o

248 port that stabilization of FGF2 levels using controlled release PLGA microspheres improves expression

249 tro digestibility test showed a slow glucose-controlled release potential of khambir that reflected i

250 indings have implications for all manners of controlled release processes, especially for site-specif

251 For the controlled release Procet 8 formulation, we calculated a

252 a high lipid:DOX ratio exhibited a fast and controlled release profile in combination with mild HT,

253 optimal formulation based on siRNA loading, controlled release profile, and mRNA knockdown.

254 ficiently deliver multiple therapeutics with controlled release properties and increased tumor deposi

255 The structure and controlled release properties of the KMP2 hydrogel were

256 t dissolution profiles of several commercial controlled-release proton pump inhibitors in simulated s

257 We achieved controlled release rates of multiple antiretrovirals ran

258 the mesoporous silica shell that allowed the controlled release, resulting in a NIR-responsive DNA-ga

259 Analysis of beta-galactosidase activity and controlled release reveals that chitosan-grafted hydroge

260 This review highlights the important role of controlled release science in development of reliable me

261 s been an important field for the Journal of Controlled Release since the early 2000s.

262 In 2018, the Controlled Release Society introduced a new, member-led

263 Next, we discuss the use of controlled release strategies to tune the balance betwee

264 Moreover, an in vitro controlled release study was conducted with a fortified

265 ally, a range of applications enabled by the controlled release system based on PCMs are presented to

266 Accordingly, we developed a controlled release system capable of generating a steady

267 This local controlled release system is capable of shifting the bal

268 We developed a controlled release system to deliver recombinant periost

269 velopment as a therapeutic requires a robust controlled release system.

270 Controlled release systems and nanoparticles are being i

271 Controlled release systems are an effective means for lo

272 Unfortunately, unlike controlled release systems for drugs, single-administrat

273 Here, we provide an overview of controlled release systems for local delivery and we rev

274 The widespread use of controlled release systems is hindered by limitations, w

275 which was accomplished by local placement of controlled release systems that sustain a gradient of th

276 Controlled-release systems capable of responding to exte

277 le delivery and discusses efforts to develop controlled-release systems for delivery of biopharmaceut

278 Thus, the inability to stabilize proteins in controlled-release systems represents a major obstacle i

279 New controlled release technologies will be needed to contin

280 nsdermal drug delivery (TDD) is a successful controlled release technology.

281 With controlled-release technology, it is now possible to ach

282 Mathematical models of controlled release that span the in vitro to in vivo tra

283 biomedical engineering challenge to develop controlled release therapeutics is appraised, with comme

284 Since the early days of the Journal of Controlled Release, there has been considerable interest

285 onporous hybrids drive substrate capture and controlled release through chemical reactivity.

286 the study was to produce nanoparticles with controlled release to overcome these obstacles.

287 ) to encapsulate 6-shogaol and undertake its controlled release to the proposed drug target (colon).

288 icient polymer photodegradation and remotely controlled release using near-IR laser light at an unpre

289 is work, to ultimately develop site-specific controlled release vehicles for NO, the NO donor S-nitro

290 DOX-loaded MONs exhibit carrier degradation-controlled release via cleavage of diselenide bonds, res

291 her evidence for an ion pairing mechanism of controlled release was provided through the measurement

292 evice for dry reagent storage and subsequent controlled release, we tested this device with the malar

293 ion (i.e., fractional uptake of enzyme), and controlled release were studied as a function of pH and

294 vel class of thermo-responsive materials for controlled release, where the payloads encapsulated in a

295 nd prospects of recombinant polymers used in controlled release will be reviewed.

296 Light-activatable drugs offer the promise of controlled release with exquisite temporal and spatial r

297 ed a delivery system with pH-sensitivity for controlled release with promising properties for food sa

298 0 +/- 0.85%), spherical shape, pH-responsive controlled release, with faster release in the presence

299 In the encapsulated strategy, controlled release without exposing the solid ferrate to

300 whether targeted treatment of insomnia with controlled-release zolpidem (zolpidem-CR) in suicidal ad