ライフサイエンスコーパス: convoluted tubule

1 ria, and morphological changes in the distal convoluted tubule.

2 n of Bowman's space and the initial proximal convoluted tubule.

3 imal tubule, thick ascending limb, or distal convoluted tubule.

4 cotransporter (NCC) expressed in the distal convoluted tubule.

5 ated Na(+)-Cl(-) cotransporter in the distal convoluted tubule.

6 decreased reabsorption of NaCl in the distal convoluted tubule.

7 uded the thick ascending limb and the distal convoluted tubule.

8 e sites in vivo, predominantly in the distal convoluted tubule.

9 thick ascending limb, but also by the distal convoluted tubule.

10 enhanced WNK pathway activity in the distal convoluted tubule.

11 or salt reabsorption in the mammalian distal convoluted tubule.

12 timulate transport in the TAL and the distal convoluted tubule.

13 e, whereas it is transcellular in the distal convoluted tubule.

14 protein produced predominantly in the distal convoluted tubule.

15 ng limb of the loop of Henle, and the distal convoluted tubule.

16 in mDCT15 cells, a model of the mouse distal convoluted tubule.

17 in with predominant expression in the distal convoluted tubule.

18 e cotransporter 2 (SGLT2) along the proximal convoluted tubule.

19 trate must pass before reaching the proximal convoluted tubule.

20 RNA was markedly increased in renal proximal convoluted tubules.

21 ricted to the epithelium of the renal distal convoluted tubules.

22 d tubular atrophy particularly in the distal convoluted tubules.

23 ibution of the RENTAC conjugates in proximal convoluted tubules.

24 ical segments, including proximal and distal convoluted tubules.

25 with a putative cell of origin in the distal convoluted tubules.

26 basement membrane thickening in the proximal convoluted tubules.

27 sured by patch-clamping of split-open distal convoluted tubule 2 (DCT2)/connecting tubule (CNT) from

28 progenitor cells leads to progressive distal convoluted tubule abnormalities and beta-catenin/mTOR hy

29 GPR39 is expressed in the distal convoluted tubule and collecting duct of the kidney, and

30 aquaporin-2, and pendrin showed that distal convoluted tubule and connecting segment cells, A-type i

31 n calcium entry into the cells of the distal convoluted tubule and connecting segment of the nephron,

32 MK K(+) channel did not change in the distal convoluted tubule and decreased slightly in the cortical

33 s not impair calcium transport in the distal convoluted tubule and indicates that thiazides should be

34 mediator of salt reabsorption in the distal convoluted tubule and is a key determinant of the blood

35 transcript was detected only in the proximal convoluted tubule and proximal straight tubule.

36 f the nephron, comprising part of the distal convoluted tubule and the connecting tubule, and regulat

37 r apical sodium transporters in the proximal convoluted tubule and the distal convoluted tubule of th

38 (+)-2Cl(-) cotransporter NKCC2 in the distal convoluted tubule and the thick ascending limb of Henle'

39 t, with their functional roles in the distal convoluted tubule and thick ascending limb, respectively

40 d Na(+) and Cl(-) reabsorption in the distal convoluted tubule and water reabsorption in the collecti

41 ts in proximal tubule, loop of Henle, distal convoluted tubule, and cortical and medullary collecting

42 e diabetic thick ascending limb, late distal convoluted tubule, and principal cells all adopt a gene

43 ll types, proximal convoluted tubule, distal convoluted tubule, and principal cells.

44 nding limb of Henle's loop and/or the distal convoluted tubule, and these disorders generate the grea

45 l cells in the thick ascending limbs, distal convoluted tubules, and collecting ducts of mice.

46 ented in podocytes, proximal tubules, distal convoluted tubules, and the apical membrane of collectin

47 -sensitive Na-Cl cotransporter of the distal convoluted tubule appears to be the chief molecular targ

48 Empagliflozin mitigated distal convoluted tubule area reduction, normalized NaCl cotran

49 kidney, recent evidence points to the distal convoluted tubule as a possible site of mineralocorticoi

50 nating in widespread destruction of proximal convoluted tubules at the glomerulotubular junction.

51 y for normal salt reabsorption in the distal convoluted tubule because of the need for K(+) recycling

52 d absorption are sharply reduced in proximal convoluted tubules, blood pressure is reduced and there

53 e SPAK mainly activates NCC along the distal convoluted tubule, but the kinases may compensate for ea

54 whereas autoantibodies targeting the distal convoluted tubule can cause acquired Gitelman syndrome.

55 ve Na+-Cl- cotransporter (NCC) of the distal convoluted tubule cause Gitelman's syndrome, an inherite

56 tive ABCB1(low) (ACHN, normal human proximal convoluted tubule cell) cells.

57 llular calcium homeostasis of renal proximal convoluted tubule cells and establish a causal link betw

58 esults of siRNA transfection in mouse distal convoluted tubule cells and those of unilateral ureteral

59 mal precursor states that mature to proximal convoluted tubule cells broadly expressing physiology-im

60 expression model and in native murine distal convoluted tubule cells in culture.

61 AKI which leads to inflammation in proximal convoluted tubule cells in the kidney.

62 In Cav1-/- mice, distal convoluted tubule cells were completely devoid of Cav1 a

63 h localized to the apical membrane of distal convoluted tubule cells, T58M Ncc localized primarily to

64 chief apical sodium entry pathway of distal convoluted tubule cells, we prepared an affinity-purifie

65 chemistry showed TSC labeling only in distal convoluted tubule cells.

66 d on an intronic regulatory region in distal convoluted tubule cells.

67 o a lesser extent, in segments of the distal convoluted tubule cells.

68 in the extracellular matrix surrounding the convoluted tubules, collecting ducts and loops of Henle

69 nd basolateral Rhcg expression in the distal convoluted tubule, connecting segment, and initial colle

70 alcium-sensing receptor (CaSR) in the distal convoluted tubule (DCT) activates the NaCl cotransporter

71 The importance of the kidney distal convoluted tubule (DCT) and cortical collecting duct (CC

72 t-absorptive pathway in the mammalian distal convoluted tubule (DCT) and is the site of action of one

73 er in the basolateral membrane of the distal convoluted tubule (DCT) and plays an important role in t

74 at WNK3 is expressed in the nephron's distal convoluted tubule (DCT) and stimulates NCC activity.

75 n at residue T303 is localized in the distal convoluted tubule (DCT) but not in the thick ascending l

76 Na(+) transport in the renal distal convoluted tubule (DCT) by the thiazide-sensitive NaCl c

77 In kidney distal convoluted tubule (DCT) cells, stimulation of Na+/K(+)-A

78 The distal convoluted tubule (DCT) comprises two subsegments, DCT1

79 NaCl cotransporter (NCC) of the renal distal convoluted tubule (DCT) controls ion homeostasis and art

80 of the proximal tubule brush border, distal convoluted tubule (DCT) dilatation, and kidney fibrosis

81 , CD8(+) T cells directly contact the distal convoluted tubule (DCT) in the kidneys of DOCA-salt mice

82 m-chloride cotransporter (NCC) in the distal convoluted tubule (DCT) is solely responsible.

83 The mammalian distal convoluted tubule (DCT) makes an important contribution

84 Cl cotransporter (NCC) present in the distal convoluted tubule (DCT) of the kidney.

85 transcellular Ca(2+) transport in the distal convoluted tubule (DCT) of the kidney.

86 ride cotransporter (NCC) in the renal distal convoluted tubule (DCT) plays a critical role in regulat

87 The distal convoluted tubule (DCT) plays a critical role in renal s

88 from the thick ascending limb (CTAL)/distal convoluted tubule (DCT) region of the mouse nephron.

89 NaCl cotransporter NCC in the kidney distal convoluted tubule (DCT) regulates urinary NaCl excretion

90 Thiazide diuretic drugs act in the distal convoluted tubule (DCT) to inhibit a Na+Cl- cotransporte

91 ates Mg(2+) reabsorption in the renal distal convoluted tubule (DCT) via engagement of its receptor o

92 basolateral potassium channel in the distal convoluted tubule (DCT), comprising the inwardly rectify

93 on the thick ascending limb (TAL) and distal convoluted tubule (DCT), key sites of magnesium reabsorp

94 In the distal convoluted tubule (DCT), potassium imbalance causes WNK

95 showed that Pcbd1 is expressed in the distal convoluted tubule (DCT), where Pcbd1 transcript levels a

96 lciuria and marked hyperplasia of the distal convoluted tubule (DCT), whereas the opposite is true in

97 in the apical plasma membrane of CON distal convoluted tubule (DCT).

98 tive Na-Cl cotransporter (NCC) in the distal convoluted tubule (DCT).

99 calcium and magnesium handling within distal convoluted tubule (DCT).

100 or (CaSR) are highly expressed in the distal convoluted tubule (DCT).

101 ucial for calcium reabsorption in the distal convoluted tubule (DCT).

102 e major NaCl transport protein in the distal convoluted tubule (DCT).

103 Ca(2+) reabsorption via TRPV5 in the distal convoluted tubule (DCT).

104 of the thick ascending limb (TAL) and distal convoluted tubule (DCT).

105 or alpha-Klotho (KL) localizes to the distal convoluted tubule (DCT).

106 f the NaCl cotransporter (NCC) in the distal convoluted tubule (DCT).

107 e types of cells, which form the late distal convoluted tubule (DCT2), connecting tubule segments 1 a

108 ls and intercalated cells in the late distal convoluted tubules (DCT2), connecting tubules, and colle

109 Following microinjection into distal convoluted tubules (DCTs) 46.1 +/- 6.1 % (n = 8) of the

110 The thick ascending limbs (TALs) and distal convoluted tubules (DCTs) critically utilize glucose/pyr

111 al tubule precursors into early stage distal convoluted tubules (DCTs) during nephrogenesis.

112 ing limbs of the loop of Henle and by distal convoluted tubules (DCTs).

113 ascending limb of Henle (TAL) and in distal convoluted tubules (DCTs): Ksp-cre;Pth1r(fl/fl) Mutant m

114 l nephron structures (podocytes and proximal convoluted tubules) despite the presence of activated No

115 ignatures in glomerular cell types, proximal convoluted tubule, distal convoluted tubule, and princip

116 atest accumulation of renox mRNA in proximal convoluted tubule epithelial cells.

117 ion and a decrease in the mass of the distal convoluted tubule, exclusive to DCT1.

118 infection, epithelial cells of the proximal convoluted tubules frequently contained abnormal mitocho

119 rved between the development of the granular convoluted tubules (GCT) of the SMG in these mice and SM

120 ibited defects in the maturation of granular convoluted tubules (GCTs), which is regulated through se

121 conducting primary filtrate to the proximal convoluted tubule has been Bowman's space (BS) (1).

122 ption in the thick ascending limb and distal convoluted tubule has been proposed as the underlying ca

123 The distal convoluted tubule has been proposed to sense plasma [K(+

124 3 probes gave intense labeling of the distal convoluted tubule in pig kidney but (unexpectedly) no de

125 nnel, which presumably have decreased distal convoluted tubule intracellular chloride.

126 We conclude that the distal convoluted tubule is an important site of action of the

127 that potassium reabsorption in the proximal convoluted tubule is passive in nature and depends partl

128 d this was a result of differences in distal convoluted tubule length when salt was given with aldost

129 ression in kidney was restricted to proximal convoluted tubules; little or no expression was observed

130 important transporters in the renal proximal convoluted tubule, namely Na-H exchanger 3, Na-K ATPase,

131 he proximal convoluted tubule and the distal convoluted tubule of the kidney, respectively.

132 ing active Ca(2+) reabsorption in the distal convoluted tubule of the kidney.

133 ajor role in salt reabsorption in the distal convoluted tubule of the nephron(2,3), and mutations in

134 dullary potassium channel in the late distal convoluted tubule of WNK1(+/FHHt) mice, which could cont

135 a strong decrease in NCC labeling in distal convoluted tubules of aldosterone-escape rats with no ch

136 hy (OCT) revealed that cells lining proximal convoluted tubules of living donor kidneys (LDKs) procur

137 Kidney expresses RALDH2 in the proximal convoluted tubules of the cortex but not in the distal c

138 protein primarily in the proximal and distal convoluted tubules of the cortex but not in the glomerul

139 ne of transporting epithelia in the proximal convoluted tubules of the kidney and the small intestine

140 lication and gene expression in the proximal convoluted tubules of the kidney by causing interstitial

141 ule and nucleic acid analogs to the proximal convoluted tubules of the kidney following systemic deli

142 lial cells of the mammary glands; (e) distal convoluted tubules of the kidney; (f) epidermal keratino

143 hate co-transporter NaPi-IIa in the proximal convoluted tubules of the outer renal cortex, assessed b

144 fect on lithium reabsorption in the proximal convoluted tubule or loop of Henle.

145 rgeting the thick ascending limb, the distal convoluted tubule or the collecting system.

146 Segments of superficial proximal convoluted tubules or cysts, isolated by upstream and do

147 tubules of the cortex but not in the distal convoluted tubules or glomeruli.

148 The proximal convoluted tubule (PCT) and the medullary thick ascendin

149 olic disease originating from renal proximal convoluted tubule (PCT) epithelial cells, remains incomp

150 The proximal convoluted tubule (PCT) reabsorbs most of the filtered b

151 t potassium reabsorption in the rat proximal convoluted tubule (PCT).

152 Following microinjection into proximal convoluted tubules (PCTs), 18.5 +/- 2.9 % (mean +/- s.e.

153 6) M angiotensin II to the lumen of proximal convoluted tubules perfused in vivo had no effect on the

154 The transport of organic anions in proximal convoluted tubules plays an essential role in the active

155 progenitor cells caused an absence of distal convoluted tubules, renal cysts, and fibrosis with beta-

156 agnesium (Mg(2+)) reabsorption in the distal convoluted tubule represents the final step before Mg(2+

157 ption in the thick ascending limb and distal convoluted tubule, respectively.

158 proximal tubule expansion, while the distal convoluted tubule response is exaggerated.

159 nephron that results in expansion of distal convoluted tubule size but loss of overall tubule densit

160 e expansion of fluorescence-labeled proximal convoluted tubules, supporting our hypothesis that Nek1-

161 We further demonstrated proximal convoluted tubule targeting features of RENTAC conjugate

162 t cellular phenotype with decreased granular convoluted tubules that are accompanied by an increased

163 K-2Cl cotransporter [NKCC2]), and the distal convoluted tubule (the thiazide-sensitive Na-Cl cotransp

164 Henle, the intercalated cells of the distal convoluted tubule, the connecting segment, and all inter

165 tive region of the nephron, i.e., the distal convoluted tubule, the connecting tubule, and the cortic

166 Henle, the Na-Cl cotransporter of the distal convoluted tubule, the epithelial Na+ channel of the col

167 Along the distal convoluted tubule transcellular reabsorption via heterom

168 rption across the S2 segment of the proximal convoluted tubule, transepithelial potential differences

169 region and caused an increase in late distal convoluted tubule volume.

170 tential difference (PD) at the late proximal convoluted tubule was +2.1 +/- 0.3 mV (lumen positive) a

171 hile fractional reabsorption in the proximal convoluted tubule was enhanced.

172 ium concentration ratio at the late proximal convoluted tubule was raised in the low-K+ animals (1.50

173 Fractional water reabsorption in proximal convoluted tubules was enhanced in potassium-depleted ra

174 use TRPV5 and Klotho coexpress in the distal convoluted tubule, we investigated whether Klotho regula

175 tion studies showed that developing proximal convoluted tubules were the most severely hypoxic nephro

176 ifically expressed in the epididymis-a long, convoluted tubule where sperm mature and acquire fertili

177 the dissociation can be traced to the distal convoluted tubule, where calcium and sodium transport ar

178 P receptor is highly expressed in the distal convoluted tubule, where it may have a distinct effect o

179 uitous kinase isoform of WNK1, in the distal convoluted tubule, which in turn, stimulates the activit

180 try revealed normal morphology of the distal convoluted tubule with reduced NCC expression.

181 by reduced levels of TRPV5 protein in distal convoluted tubules, with a concomitant increase in TRPV5