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1 ference akin to that of DNMT3B, which is non-cooperative.
2 that their partners would be relatively more cooperative.
3 Opening of the two channels in the dimer is cooperative.
4 endent reductions of NAD(+) and NADP(+) were cooperative.
5 o the bimetallic cleft, enabling metal-metal cooperative 2 e(-) substrate reductions as shown by the
6 utylselanyl)phenyl]propynols promoted by the cooperative action between diorganyl diselenides and iro
12 ed novel mechanistic features concerning the cooperative action, and functional specialization, of th
14 ions of YpkA and YopJ to inhibition and that cooperative actions by multiple Yop effectors are requir
18 hia lanceolata, a species where males lek in cooperative alpha-beta pairs, we tested five non-exclusi
21 acterized as strategic or mixed-motive, with cooperative and competitive elements influencing its app
22 ic models have also enabled the inference of cooperative and competitive metabolic interactions betwe
24 e discovery of sequence features determining cooperative and differential TF binding across tissues.
25 e trackways may capture a unique snapshot of cooperative and sexually divided foraging behavior in La
26 aled that the Orai1 gating process is highly cooperative and strongly allosteric, likely driven by a
27 l-based immunotherapy, with an unanticipated cooperative antitumor effect of LDH inhibition and IL-21
28 SOMMs are synthesized via a surface-limited cooperative assembly (SLCA) on water-removable substrate
29 d "knobs-into-holes" interfaces, suggested a cooperative assembly process of heavy chains in heterodi
34 c conditions have been shown to also promote cooperative behavior and the formation of vertebrate soc
36 tosterone as a psychobiological correlate of cooperative behavior under ecological conditions with ev
39 ly adolescence as a phase of rapid change in cooperative behaviours, and highlight this as a key deve
40 coordination, including social preferences, cooperative beliefs, (emotion) signaling, and, in partic
41 namics (MD) simulations, we established that cooperative binding between nucleotides inside a CA hexa
42 do not contain the residues underlying this cooperative binding mode; consequently, the direct cell
45 imetry (ITC) measurements indicated negative cooperative binding of inhibitor to the dimeric protein,
46 us, the multivalent binding of TNRC6 enables cooperative binding of miRNA-AGO complexes to target RNA
48 binding region of TNRC6B, we observed strong cooperative binding to dual sites, with almost no singly
50 2 can homo- or heterodimerize, essential for cooperative binding to sequence-paired sites (SPS) locat
52 appears to have an extremely high degree of cooperative binding, resulting in a virtual on/off switc
53 ongitudinal data on the social dynamics of a cooperative bird species, the wire-tailed manakin, to ev
55 in long-tailed tits (Aegithalos caudatus), a cooperative breeder that risks inbreeding by living alon
60 nces in the way groups form at the origin of cooperative breeding predicts the level of group complex
62 with multiple binding sites characterized by cooperative Ca(2+) binding, such as calmodulin and calre
64 m-aminooxyacetic acid and 2-pyridone-enabled cooperative catalysis for the beta- and gamma-C(sp(3))-H
67 organocatalytic, metal-catalyzed as well as cooperative catalytic conditions has resulted in numerou
69 ties of many crystalline materials depend on cooperative changes in lattice arrangements in response
70 generate persistent firing when clusters of cooperative channels are present together with non-coope
71 jacent stacks that enables a transition with cooperative character to proceed within layers of orange
74 nctionalities that can be utilized to design cooperative CO(2) adsorbents, providing further means of
75 metal-organic frameworks exhibiting two-step cooperative CO(2) adsorption, we report a family of robu
76 ese results reveal the structural origins of cooperative cofilin binding and actin filament severing.
78 an be explored using computational models of cooperative/competitive degradation by multiple protease
79 nd nonkin, and they favor first-order kin in cooperative contexts, so we conclude that long-tailed ti
80 tain information about potential partners in cooperative contexts: we prefer partners who are compete
86 organoid and PDX models we could confirm the cooperative effects between chemotherapy and CDK4/6 inhi
88 the same monomer side chain produced optimal cooperative effects in improving the macroscopic adhesio
89 tal-to-insulator transition is linked to the cooperative effects of changes in the V-O bond length, l
91 ualized Treatment." The workshop facilitated cooperative engagement of transplant community stakehold
92 Our results suggest that being embedded in cooperative environments substantially enhances the soci
93 ency to physically associate with others and cooperative enzymatic activity can coevolve, leading to
98 r individuals, and why humans' unprecedented cooperative flexibility is nevertheless culturally paroc
100 proteolysis indicate that H6 displays poorly cooperative fold, higher flexibility, and kinetic instab
102 main-wise folding, backtracking folding, and cooperative folding, modulated by interdomain interactio
104 lement (TIE) of Klk1b21, suggesting that the cooperative function of EBE and TIE is essential for med
105 allows for the precise placement of multiple cooperative functional groups within a framework, leadin
108 The shared "we" promotes not only proximal cooperative goals but also distal ones via the construct
109 observation adds to our growing knowledge of cooperative group behavior and its importance in predato
110 eatment of Cancer/Invasive Fungal Infections Cooperative Group criteria, and assessed risk factors fo
112 ledge, we conducted the first AT/RT-specific cooperative group trial, ACNS0333, to examine the effica
115 mentary approaches and collaboration of many cooperative groups in the study of PET-guided therapy.
117 Pediatric Oncology and Haematology pediatric cooperative groups, important variables were defined to
119 ion that corresponds to a greatly diminished cooperative GTPase activity in comparison to native Drp1
120 dividuals 62-81 years of age from the German Cooperative Health Research in the Region of Augsburg (K
121 2 diabetes and >1,000 plasma proteins in the Cooperative Health Research in the Region of Augsburg (K
122 , these data serve as a new paradigm for how cooperative homeodomain transcription factor binding can
123 edly gain DNA binding specificity by forming cooperative homodimers on precisely spaced and oriented
124 ort a new approach to radical hydrogenation: cooperative hydrogen atom transfer (cHAT), where each hy
125 bactericidal, reinforcing the evidence that cooperative immunity induced by antigen combinations can
127 rough a series of titrations, we show that a cooperative interaction, involving the coordination of t
128 ALY-binding pattern reveal insights into its cooperative interactions and mode of action in regulatin
129 permeable structures that are stabilized by cooperative interactions between IM and OM proteins(2,3)
130 rface population of bound molecules, promote cooperative interactions between neighboring SBPs and hi
131 the nervous system, however, the function of cooperative interactions between voltage-dependent ionic
132 hen demonstrate the quantitative analysis of cooperative interactions by measuring Cbf1p binding at s
133 phasic Is motoneurons display competitive or cooperative interactions during innervation of the same
134 r, our findings highlight that understanding cooperative interactions in multicomponent noncovalent s
135 Taken together, these data suggest that the cooperative interactions of beta-arrestin with both the
136 ns in STFs mirror the more electrostatic and cooperative interactions that underlie the energy-sparin
138 entirely by CL31, suggesting that transient cooperative interclonal interactions are sufficient to p
139 present across multiple competitive (but not cooperative) intergroup contexts and appears to be yoked
140 m extension (VBP15-LTE) was conducted by the Cooperative International Neuromuscular Research Group (
141 of the fundamental biology of AAV as well as cooperative international research and clinical trials w
142 Together, these observations demonstrate a cooperative interplay between two RBPs, triggered differ
144 e here demonstrate that clusters of strongly cooperative ion channels can plausibly form bistable con
145 nnamyl electrophiles in the enantioselective cooperative isothiourea/Ir catalyzed alpha-alkylation wa
147 Targeting BTN3A1 therefore orchestrates cooperative killing of established tumors by alphabeta a
148 3A WT enzyme under conditions that favor non-cooperative kinetic mechanism as well as DNMT3A Arg882Hi
149 nd that A. finegoldii FabI (AfFabI) displays cooperative kinetics and uses NADH as a cofactor, and it
150 ich often have functional properties such as cooperative ligand binding or allosteric regulation(3).
151 tion factor p53, which binds DNA in a highly cooperative manner to control expression of a plethora o
152 ranscription factors (TFs) can bind DNA in a cooperative manner, enabling a mutual increase in occupa
153 to the -10 element of the promoter DNA in a cooperative manner, which restores otherwise inactive pr
156 mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced enzymatic act
160 remain intact, cells elongate and align into cooperative migratory packs, and mesenchymal markers of
162 Kinetic and computational studies support a cooperative mode of catalysis wherein two molecules of t
166 an important ligand class for investigating cooperative multimetallic interactions of bioinorganic c
167 trend to control many chemical reactions by cooperative multiple weak interactions have emerged as o
168 cal, cellular, and organismal level that the cooperative nature of DNA binding is reduced by phosphor
169 les of globular protein folding, such as the cooperative nature of the reaction, their folding pathwa
170 nd its extensions parsimoniously explain the cooperative nature of the social learning advantage, org
172 evolved to encourage individuals to fulfill cooperative obligations without the negative quality tha
173 least one previous treatment and an Eastern Cooperative Oncology Group (ECOG) performance status of
174 Patients were required to have an Eastern Cooperative Oncology Group (ECOG) performance status of
175 tinum-based chemotherapy, and had an Eastern Cooperative Oncology Group (ECOG) performance status of
176 age (< 75 and >= 75 years), baseline Eastern Cooperative Oncology Group (ECOG) performance status sco
178 C, Child-Pugh class A liver disease, Eastern Cooperative Oncology Group Performance Status (ECOG PS)
179 high vs low TMTV showed worse/higher Eastern Cooperative Oncology Group performance status (ECOG PS)
181 s or corticosteroid requirement, and Eastern Cooperative Oncology Group performance status less than
182 , or fallopian tube carcinoma and an Eastern Cooperative Oncology Group performance status of 0 or 1
183 ere adults (aged >=18 years) with an Eastern Cooperative Oncology Group performance status of 0 or 1
184 who were aged 18 years or older with Eastern Cooperative Oncology Group performance status of 0 or 1
185 c triple-negative breast cancer, and Eastern Cooperative Oncology Group performance status of 0 or 1
186 d stage IIIB-C or IV melanoma and an Eastern Cooperative Oncology Group performance status of 0 or 1
187 -oesophageal adenocarcinoma, with an Eastern Cooperative Oncology Group performance status of 0 or 1,
188 ients aged 18 years or older with an Eastern Cooperative Oncology Group performance status of 0 or 1,
189 ed, recurrent or metastatic disease, Eastern Cooperative Oncology Group performance status of 0 or 1,
190 ncer (determined histologically) and Eastern Cooperative Oncology Group performance status of 0 or 1,
191 ractory non-Hodgkin lymphoma, had an Eastern Cooperative Oncology Group performance status of 0 or 1,
192 ous carcinoma of the cervix, with an Eastern Cooperative Oncology Group performance status of 0 or 1,
193 were aged 18 years or older with an Eastern Cooperative Oncology Group performance status of 0 or 1.
194 tidisciplinary clinical team, and an Eastern Cooperative Oncology Group performance status of 0 or 1.
195 their metastatic disease, and had an Eastern Cooperative Oncology Group performance status of 0 or 1.
196 stage II or III breast cancer and an Eastern Cooperative Oncology Group performance status of 0 or 1.
197 no previous systemic treatment; and Eastern Cooperative Oncology Group performance status of 0 or 1.
198 e advanced or metastatic STS who had Eastern Cooperative Oncology Group performance status of 0 to 2
199 or evaluable non-measurable disease, Eastern Cooperative Oncology Group performance status of 0, 1, o
201 (61.8-75.0) and the majority had an Eastern Cooperative Oncology Group performance status of 0-1 (14
202 ancer aged at least 18 years with an Eastern Cooperative Oncology Group performance status of 0-1 rec
203 neous squamous cell carcinoma and an Eastern Cooperative Oncology Group performance status of 0-1) re
204 -IIIA non-small-cell lung cancer, an Eastern Cooperative Oncology Group performance status of 0-1, an
206 nti-CD38 monoclonal antibody with an Eastern Cooperative Oncology Group performance status of 0-2 wer
207 cs stage IC-IV ovarian cancer and an Eastern Cooperative Oncology Group performance status of 0-2 wer
208 nced HER2-negative breast cancer, an Eastern Cooperative Oncology Group performance status of 0-2, an
209 r recurrent biliary tract cancer, an Eastern Cooperative Oncology Group performance status of 0-2, an
210 ntreated acute myeloid leukaemia, an Eastern Cooperative Oncology Group performance status of 0-2, an
211 us stem-cell transplantation, had an Eastern Cooperative Oncology Group performance status of 0-2, an
213 women aged 18 years or older with an Eastern Cooperative Oncology Group performance status of 0-2, li
214 platinum-based chemotherapy, and an Eastern Cooperative Oncology Group performance status of 0-2.
215 of high-risk multiple myeloma and an Eastern Cooperative Oncology Group performance status of 0-2.
216 ies (two vs none: 4.50, 1.33-15.28), Eastern Cooperative Oncology Group performance status of 2 or hi
217 ed diffuse large B-cell lymphoma, an Eastern Cooperative Oncology Group performance status of 2 or le
218 ne chemotherapy regimens and with an Eastern Cooperative Oncology Group performance status of 2 or le
219 eir last line of therapy, and had an Eastern Cooperative Oncology Group performance status of 2 or le
220 re aged 18 years or older and had an Eastern Cooperative Oncology Group performance status of 2 or le
221 immunomodulatory agent), and had an Eastern Cooperative Oncology Group performance status of 2 or lo
222 ologically proven diagnosis of SCLC, Eastern Cooperative Oncology Group performance status of 2 or lo
223 t least one line of therapy, with an Eastern Cooperative Oncology Group performance status of 2 or lo
224 hemistry at a central laboratory; an Eastern Cooperative Oncology Group performance status score 0 or
225 o hypomethylating agents and with an Eastern Cooperative Oncology Group performance status score of 0
226 s INI1) alterations, or both; and an Eastern Cooperative Oncology Group performance status score of 0
227 nt regimens for advanced disease, an Eastern Cooperative Oncology Group performance status score of 0
228 nd immunomodulatory drug; and had an Eastern Cooperative Oncology Group performance status score of 2
229 Additional criteria included an Eastern Cooperative Oncology Group performance status score of 2
230 5-15 mm in maximum diameter) and an Eastern Cooperative Oncology Group performance status score of l
231 pre-LT PS using the 5-point modified Eastern Cooperative Oncology Group scale and used Cox regression
232 g carboplatin and paclitaxel, and an Eastern Cooperative Oncology Group status of 0 or 1 were eligibl
236 components of such multigenic loci may play cooperative or competing roles in driving disease progre
237 ity of offspring in a brood start to express cooperative (or competitive) behavior, they induce great
238 l environments induce the expression of more cooperative (or more competitive) behavior in focal larv
239 namine organocatalysis, NHC-organocatalysis, cooperative organo/metal catalysis, bifunctional organoc
240 two topics of interest from the literature: cooperative origin firing and replication fork barriers.
241 2,847 patients registered in the Consecutive Cooperative Osteosarcoma Study Group database with prima
242 bond activation of peptidomimetics employing cooperative palladium/copper catalysis in water is devel
243 think parents view their children as worthy cooperative partners, but because special obligations an
244 resident cell populations implicate complex cooperative pathways in IFN-alpha/beta induction and res
245 bserve the emergence of superradiance, i.e., cooperative phenomena arising from the collective nature
248 o-magneto-mechanical disruption by ELF MF of cooperative polyion complexes that are widely used for d
250 that CR binding to the HET-s PFD involves a cooperative process entailing the formation of a complex
251 pose that voluntary leaders can facilitate a cooperative process of local rule creation by exhibiting
254 both Ag(+) and Cd(2+) react with MT to yield cooperative products, i.e., Ag(4)-MT and Cd(4)-MT, these
255 or 2 (CI-2) is a classic model for two-state cooperative protein folding and is one of the most exten
256 our interactions from competitive rivalry to cooperative pursuit of a joint goal, and second, we assu
257 sis, we designed and executed an innovative, cooperative, rapid-response translational-research progr
259 g sites, which can be used to achieve highly cooperative receptors that still retain high affinity.
261 ight a novel role for a BRD4-GATA4 module in cooperative regulation of a cardiomyocyte-specific gene
262 PS2 subunits in a filament results in highly cooperative regulation, greatly exceeding the limits of
265 ome nonhuman animals form adaptive long-term cooperative relationships with nonkin that seem analogou
270 lity for investigating and understanding how cooperative signaling pathways drive cell fate acquisiti
271 ve the potential to participate in tandem or cooperative small-molecule activation and catalysis.
272 ings demonstrate a strategy for metal/ligand cooperative small-molecule activation that is well-suite
277 ut it may also allow evolution toward a more cooperative, stable, and inclusive approach to governanc
278 a protein knot can be formed during a single cooperative step of folding but occurs at the expenses o
279 in both development and monitoring of large cooperative studies, especially clinical trials, outside
280 Here we report the direct observation of the cooperative subradiant response of a two-dimensional squ
281 of the dimeric protein, the network yields a cooperative supramolecular assembly with a hybridization
283 tion along the thin filament and key for the cooperative switching between heart muscle contraction a
284 ddition of aryl iodides to enals promoted by cooperative (terpy)Pd/NHC catalysis was developed that g
286 ta) production from human monocytes requires cooperative Toll-like receptor and IFNalpha/beta signali
287 we show that EPS of Salmonella biofilms is a cooperative trait whose benefit is shared among cells, a
290 Collectively, these studies suggest that cooperative transactivation of the bICP0 E promoter by t
291 pe Francophone du Myelome, The Dutch-Belgian Cooperative Trial Group for Hematology Oncology, and Jan
292 and adds a distinct platform for metal-metal cooperative two-electron substrate reductions while circ
293 ermal denaturation, normally thought of as a cooperative two-state transition involving the native st
294 ion factor microphthalmia (MiTF) through the cooperative, unscheduled activation of several stress-si
297 s of a high water/solute permselectivity via cooperative water-wire formation could usher in an alter
298 d growth mechanism that converts to a faster cooperative wavefront mechanism during the transition.
299 nteracting proteins that may be functionally cooperative, we performed immunoprecipitation-mass spect