ライフサイエンスコーパス: cooperative binding

1 changes in the loop of the SL mediate their cooperative binding.

2 sigmoidal binding profile indicating highly cooperative binding.

3 , higher Ca(2)(+) affinity state, results in cooperative binding.

4 r CI dimer-dimer interactions and consequent cooperative binding.

5 ction between two consecutive PABPs promotes cooperative binding.

6 role in the mutually exclusive nature of the cooperative binding.

7 ding, suggesting that these segments mediate cooperative binding.

8 nd will also contribute significantly to the cooperative binding.

9 calorimetric characterization of homotropic cooperative binding.

10 1 was enhanced by Nox1 and NOXO1, suggesting cooperative binding.

11 that dimerization is a major contributor to cooperative binding.

12 herm is found to be indicative of positively cooperative binding.

13 ssemble on TER with hierarchical rather than cooperative binding.

14 C with defective phosphorylation-independent cooperative binding.

15 a protein coat to the site of damage through cooperative binding.

16 in-protein interactions are not critical for cooperative binding.

17 rn of the DNA helix) characterized by highly cooperative binding.

18 hancer activation that can be dissected from cooperative binding.

19 e more globular conformations correlate with cooperative binding.

20 ted to exhibit signs of both competitive and cooperative binding.

21 d calcium, which was further enhanced by CD8 cooperative binding.

22 Moderately cooperative binding (22.6 +/- 3.7 < or = omega < or = 14

23 tly increased intrinsic binding affinity and cooperative binding ability relative to PR-A.

24 However, we show here that highly cooperative binding also occurs in the (SSB)65/(SSB)56 b

25 We propose to use log-linear models to study cooperative binding among transcription factors and have

26 stedt and Brouhard report that DCX relies on cooperative binding and an affinity for growing microtub

27 This method takes advantage of the cooperative binding and catalytic properties of DNA-func

28 estriction endonuclease tetramers facilitate cooperative binding and cleavage of two short sites.

29 A molecular understanding of cooperative binding and filament severing has been imped

30 us and is likely to mediate nearest-neighbor cooperative binding and filament severing.

31 es the apo-WOC-PSII for the subsequent rapid cooperative binding and photo-oxidation of three additio

32 ce cofilin-binding site accessibility, favor cooperative binding and promote filament severing.

33 ing is nevertheless achieved, as a result of cooperative binding and reduced affinity of Arp2/3 compl

34 These structural changes are driven by the cooperative binding and subsequent hydrolysis of ATP, by

35 ere we evaluate the kinetic contributions to cooperative binding and the ability of this model to acc

36 binding free energy penalty, the absence of cooperative binding and the potential for ribosomal slid

37 exclusive switch, focusing on the effects of cooperative binding and the production of protein in bur

38 for the first time a functional link between cooperative binding and the repair reaction.

39 ause substantial changes in the magnitude of cooperative binding as expressed in the large difference

40 ctors, such as chromatin state, indirect and cooperative binding, as well as experimental factors, su

41 binding on both P'1,2 and P'2,3 substrates, cooperative binding at the arm-type sites P'2,3 was more

42 nding of FoxO1 and FoxA1/A2 possibly entails cooperative binding because FoxO1 and FoxA1/A2 facilitat

43 The PNANs also exhibit cooperative binding behavior and nuclease resistance pro

44 We identified unique cooperative binding behavior of a number of 4,6-disubsti

45 cular contacts that explains how it achieves cooperative binding between adjacent sites.

46 Cooperative binding between dimers governs the concentra

47 Furthermore, NMR data showed cooperative binding between donor and acceptor substrate

48 n metal sites, appropriate pore geometry and cooperative binding between guest molecules is responsib

49 of the mutant Hoxb8 protein, implicating the cooperative binding between Hoxb8 hexapeptide motif and

50 namics (MD) simulations, we established that cooperative binding between nucleotides inside a CA hexa

51 , DNase I footprinting assays indicated that cooperative binding between RhaR and CRP does not make a

52 of binuclear sites in EcMetAP formed through cooperative binding between the 5- and 6-coordinate Co(2

53 weaker TCR affinities for pMHC-II, a lack of cooperative binding between the TCR and CD4 coreceptor,

54 binding of 32 protein on forks too short for cooperative binding by 32 protein.

55 Many individual examples of cooperative binding by directly interacting TFs have bee

56 One mode involves cooperative binding by two GATA factors that interact wi

57 ectroscopy system is able to distinguish the cooperative binding conformation from the noncooperative

58 The approximately 50% cooperative binding conformation of wild-type PABPs indi

59 determine the binding site size and the non-cooperative binding constants to dsDNA for gp32 and I.

60 The analysis of cooperative binding data (either positive or negative) o

61 In addition to this hierarchical cooperative binding, discrimination requires a competiti

62 adhere to charged surfaces under water via a cooperative binding effect known as catechol-cation syne

63 This corresponded to a positively cooperative binding effect with an entropic difference b

64 is of TREX2 and the heterodimers indicates a cooperative binding effect within the TREX2 protomer.

65 of attractive interactions results in clear cooperative binding effects that help overcome the entro

66 In the present study, we show cooperative binding energetics between distinct hot regi

67 This cooperative binding exhibited a Hill coefficient of 1.9

68 effectively displaced by distamycin, but the cooperative binding exhibited by distamycin was eliminat

69 proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription facto

70 The relative contributions of additive and cooperative binding forces and the influence of conforma

71 nificant difference between the additive and cooperative binding forces existing among the selected r

72 The non-contiguous and cooperative binding free energies are driven entirely by

73 umber of stable configurations, explain such cooperative binding from a thermodynamic viewpoint.

74 Cooperative binding has been shown to be the mechanism u

75 cently shown that porous solids that exhibit cooperative binding have substantial energetic benefits

76 ble system that preserves key ingredients of cooperative binding; i.e., at saturation, the lattice ca

77 rangements of the Ets and AP-1 sites support cooperative binding, (ii) the bZIP motifs of Fos and Jun

78 Nonetheless, the precise role of cooperative binding in defining cell-type identity is st

79 ions in the TLR4-Mal-MyD88 complex thus show cooperative binding in MAPPIT.

80 the theory is used to tease out the role of cooperative binding in stochastic models in comparison t

81 her with the acidic tip contribute to highly cooperative binding in the (SSB)35 binding mode.

82 fied His(10)-MrpC2 and FruA-His(6) indicated cooperative binding in vitro to three sites in the fmgE

83 del B accounts for the process of positively cooperative binding, in which noncovalent bonds are redu

84 l division proteins are involved in multiple cooperative binding interactions, thus presenting a tech

85 Cooperative binding is commonly observed in proteins wit

86 Cooperative binding is eliminated by insertion of a half

87 This cooperative binding is essential for establishment and m

88 reased (GG-X-GG < X5 < X10), suggesting that cooperative binding is important for surface attachment

89 hat MepR dimers do not interact directly and cooperative binding is likely achieved by DNA-mediated a

90 for a second-order reaction, suggesting that cooperative binding is limited also by binding site acce

91 This cooperative binding is mediated by the conserved C-termi

92 Cooperative binding is most often observed in proteins,

93 er even at co-occupied sites, and that their cooperative binding is mostly mediated indirectly throug

94 Although cooperative binding is one mechanism for generating ultr

95 We have previously shown that cooperative binding is required for regulation of IgE pr

96 nked to the minimal tk promoter suggest that cooperative binding is required to activate transcriptio

97 of the D2 domain is required for adenovirus cooperative binding, it has a negative consequence upon

98 The rate of cooperative binding (ka) of both gp32 and of its proteol

99 High AGT densities resulting from cooperative binding may allow efficient search for lesio

100 how activators can operate through a simple cooperative binding mechanism but affect different steps

101 17 interaction is mediated by a specific and cooperative binding mechanism that includes two active b

102 complex with MLL, which suggests a positive cooperative binding mechanism, and the affinity for MLL

103 -bridged HBD2 dimers exhibited features of a cooperative binding mechanism.

104 n lead to a noncompetitive, uncompetitive or cooperative binding mechanism.

105 recognition that involves a metal-dependent cooperative binding mechanism.

106 BD6-FX interaction, exhibiting features of a cooperative binding mechanism.

107 concentrations is likely achieved through a cooperative binding mode.

108 do not contain the residues underlying this cooperative binding mode; consequently, the direct cell

109 These findings suggested a cooperative binding model for tallimustine in which one

110 The data support a cooperative binding model in which Nef functions as a cl

111 These data were interpreted using a cooperative binding model wherein multiple non-covalent

112 ng, consistent with the previously suggested cooperative binding model.

113 Cooperative binding occurs if the number of binding site

114 Strong cooperative binding occurs only in the presence of two o

115 Cooperative binding occurs only with both operators pres

116 Cooperative binding of a bis(tridentate) ruthenium(II) c

117 o anionic lipid headgroups, "prime" Syt1 for cooperative binding of a full complement of metal ions a

118 Cooperative binding of a ligand to multiple subsites on

119 We also report the cooperative binding of a mixture of acetylene and ethyle

120 re of this network is the mutually exclusive cooperative binding of a repressor dimer (CI) to one of

121 ver, CD-BLM mediates ds-DNA cleavage through cooperative binding of a second CD-BLM molecule to effec

122 catalytic efficiency increased 8.4-fold upon cooperative binding of a second magnesium ion (Hill coef

123 rentiation of bacterial chromatin depends on cooperative binding of abundant nucleoid-associated prot

124 -actin helical structure can be modulated by cooperative binding of actin-binding proteins.

125 n structure of the ternary complex formed by cooperative binding of activation domains from the c-Myb

126 Interestingly, this cooperative binding of ammonium sulfate salts was also e

127 is critically modulated by the specific and cooperative binding of anionic nonannular lipids close t

128 iation is reversible and is regulated by the cooperative binding of approximately two protons to the

129 e filament introduced by Arg can explain the cooperative binding of Arg to F-actin and might prevent

130 ed intrinsic protein fluorescence and highly cooperative binding of at least four Zn2+ ions (KD appro

131 that CD23 associates as an oligomer and that cooperative binding of at least two lectin domains is re

132 ctive state of a GroEL ring involves initial cooperative binding of ATP, recruiting GroES, followed b

133 ifications to the transmembrane subunits and cooperative binding of ATP.

134 that the prevailing model, based on pairwise cooperative binding of Bcd to HbP2 is not adequate.

135 ated for high affinity binding of InsP(6) by cooperative binding of both a new substrate and InsP(6).

136 ded nucleic acid binding motif that promotes cooperative binding of both aminoacylation and editing d

137 (ii) Selective and cooperative binding of both an acetato ligand and an ami

138 MMP-3 interact with the peptides, revealing cooperative binding of both domains to the triple helix.

139 omparable halogen bonds, strongly supporting cooperative binding of both ends of the diyne.

140 plot analysis of the data indicates positive cooperative binding of both recMoPrP(Q218K) and recMoPrP

141 nce follows a simple Hill plot demonstrating cooperative binding of Ca2+ to the binding sites in CaM.

142 We propose a scheme in which cooperative binding of cGMP, beginning at the CNB closes

143 Counterion condensation triggered a cooperative binding of Chi-NCs, characterised by a weak

144 erol concentration we observed high-affinity cooperative binding of cholesterol with sub-nM affinity

145 Our findings of cooperative binding of Cmr to these DNA regions and the

146 First, repression requires the cooperative binding of CodY to at least two adjacent mot

147 by a few copies of CP, RNA folding, and then cooperative binding of CP to the "labeled" nucleoprotein

148 nduced dissociation caused by the negatively cooperative binding of EGF to the second site on the EGF

149 n the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal

150 The result of this cooperative binding of ER and p65 at adjacent response e

151 ther neurotransmitter receptors, rely on the cooperative binding of extracellular small-molecule and

152 is study demonstrates that the high-affinity cooperative binding of f-ImPyIm can be enhanced signific

153 Cooperative binding of FruA and MrpC2 appears to be a co

154 h appears to be regulated by three sites for cooperative binding of FruA and MrpC2.

155 at this condition can be fulfilled is by the cooperative binding of Gag molecules to nucleic acid.

156 studies of the dynamics of the isolated and cooperative binding of gp32 molecules within the replica

157 ith the use of a mathematical model based on cooperative binding of graded and uniform factors.

158 a "click-to-fit" mechanism that involves the cooperative binding of heparan sulfate and alpha5beta1 i

159 intercalated ethidium bromide and facilitate cooperative binding of Hoechst 33258 at the minor groove

160 imetry (ITC) measurements indicated negative cooperative binding of inhibitor to the dimeric protein,

161 Cooperative binding of ion pairs to receptors is crucial

162 l coefficient of 0.60, indicating negatively cooperative binding of L-arginine.

163 Therefore traditional models involving cooperative binding of ligand or robust allosteric regul

164 ively occurs upon positively, or negatively, cooperative binding of ligand.

165 sing the McGhee-von Hippel formalism for the cooperative binding of ligands to a monodimensional latt

166 pervades macromolecular function and drives cooperative binding of ligands to macromolecules.

167 Cooperative binding of ligands to proteins can serve to

168 In the presence of Zn(2+), cooperative binding of MAM to the DR1 dimer was also obs

169 us, the multivalent binding of TNRC6 enables cooperative binding of miRNA-AGO complexes to target RNA

170 The data support cooperative binding of MPO and HK on cells such that MPO

171 y site, which corresponded to a site of weak cooperative binding of MrpC2 and FruA and boosted dev ex

172 Allele-selective inhibition may involve cooperative binding of multiple protein-RNA complexes to

173 that acts through the functional synergy and cooperative binding of multiple transcription factors.

174 Using this approach, the cooperative binding of myosin along thin filaments has b

175 inding locally, we successfully simulate the cooperative binding of myosin to actin observed experime

176 FERM domain of ezrin to NHERF regulates the cooperative binding of NHERF to bring two cytoplasmic ta

177 alter Lrp's non-specific binding affinity or cooperative binding of non-specific DNA.

178 main and provides a structural basis for the cooperative binding of one molecule of compound 3 to two

179 Non-cooperative binding of only one Ca(2+), and loss of ATPa

180 Together strong: Cooperative binding of organic (see picture, red) and in

181 of a single-myosin crossbridge, resulting in cooperative binding of other cycling crossbridges.

182 Cooperative binding of phenolic species to insulin hexam

183 Here, we examine cooperative binding of pi dimers and explore the role th

184 ed microscale thermophoresis to quantify the cooperative binding of PIP(2) and Ca(2+) to synaptotagmi

185 , the N-terminal POZ domain was required for cooperative binding of PLZF to a multimerized PLZF-RE.

186 inal motor neuron identity is established by cooperative binding of programming transcription factors

187 Such allosteric coupling leads to cooperative binding of proteasomal ATPases to 20S and pr

188 Cooperative binding of proximal sites for the same or di

189 Kinetics of cooperative binding of rat polymerase beta to a double-s

190 phaCTD) of RNA polymerase (RNAP) facilitates cooperative binding of ResD approximately P and RNAP, th

191 However, only the cooperative binding of RhoA to the central p120 domain a

192 nd revealed a strong correlation between the cooperative binding of S1 to the closed state and the mo

193 function through reduction in the nature of cooperative binding of S1.

194 and free energy measurements demonstrate the cooperative binding of S15 and the S6:S18 heterodimer, b

195 No evidence for highly cooperative binding of scRPA to ssDNA was found under an

196 NA decay is more complex and may involve the cooperative binding of several RNA-binding proteins at d

197 In contrast to the cooperative binding of SR proteins observed on the doubl

198 nd to the alternative 3' UTRs and found that cooperative binding of Staufen and HuR mediates 3'-UTR-d

199 tation genes are supposedly regulated by the cooperative binding of Ste12 and Tec1 on a PRE adjacent

200 This work sheds light on cooperative binding of TF binding proteins in regulating

201 ciated that lac promoter repression involves cooperative binding of the bidentate lac repressor tetra

202 sing microtubule affinity as well as driving cooperative binding of the CHD.

203 requirement of a 4-bp spacer and the highly cooperative binding of the dimer.

204 We conclude that cooperative binding of the hydrophobic cavity and basic

205 form the tetramer that is necessary for the cooperative binding of the repressor.

206 the fmgA gene by a novel mechanism involving cooperative binding of the response regulator FruA and t

207 duce a steady-state bimodal response without cooperative binding of the TF.

208 ter region, depends on FruA, consistent with cooperative binding of the two proteins in vivo.

209 This interaction is translated into a cooperative binding of the two proteins on the apoptotic

210 We conclude that cooperative binding of the two proteins to this promoter

211 t a DNA U-turn is induced by progressive and cooperative binding of the two TFAM HMG-box domains and

212 Pol II (rpb1-1) mutant, indicating mutually cooperative binding of these components of the transcrip

213 In turn, the simultaneous and cooperative binding of these factors is required to regu

214 roximal to other footprints, consistent with cooperative binding of these footprints.

215 The results showed strongly positive cooperative binding of three equivalents of metal per mo

216 This relation is presumed to result from the cooperative binding of three to four Ca(2+) ions at the

217 Cooperative binding of transcription factors (TFs) to pr

218 Cooperative binding of transcription factors is known to

219 The TIN2-mediated cooperative binding of TRF1 and TRF2 to telomeres has im

220 DNA polymerase binds to DNA followed by the cooperative binding of two additional molecules of the p

221 rotein represses gene expression by a highly cooperative binding of two adjacent dimers to essentiall

222 is impaired, and full activity requires the cooperative binding of two forked DNA substrate molecule

223 We observe cooperative binding of two MsrA to each CaMox with an ap

224 tively and Na(+) binding appeared to involve cooperative binding of two Na(+).

225 tion of the papillomaviruses is specified by cooperative binding of two proteins to the ori site: the

226 ay junction nucleate oligomerization through cooperative binding of two Rev molecules.

227 ent genes have been shown to be regulated by cooperative binding of two transcription factors to the

228 ins three distinct activities, which are (i) cooperative binding of two U1A proteins to a 50-nucleoti

229 Thus, one site of interaction is cooperative binding of Val 12-ras-p21 to raf and JNK.

230 subunits are independent, demonstrating that cooperative binding or concerted conformational changes

231 protein C (CENP-C) homologue Mif2 to form a cooperative binding platform for outer kinetochore assem

232 that the C-C domain interaction doubles the cooperative binding probability.

233 nd suggested to be the first occupied in the cooperative binding process activating phosphorylation f

234 lysis of the binding data reveals a possible cooperative binding process in solution.

235 This highly cooperative binding produces very sharp transitions betw

236 ssessing these activities, the CTD lacks the cooperative binding properties observed for full-length

237 We report here on the cooperative binding properties of a tetratopic ion-pair

238 emical recognition properties of DNA and the cooperative binding properties of DNA-functionalized gol

239 These observations imply that cooperative binding requires dimerization.

240 Highly cooperative binding requires the 56 amino acid intrinsic

241 This cooperative binding requires the POZ domain of BCL-6.

242 ntal units of Sir chromatin binding and that cooperative binding requiring two appropriately modified

243 appears to have an extremely high degree of cooperative binding, resulting in a virtual on/off switc

244 A further substantial contribution to cooperative binding results from the proximity of the bo

245 ule ligands that induce positive or negative cooperative binding reveals that positive cooperativity

246 P450eryF cause an ample spin shift revealing cooperative binding ( S50 = 8.2 +/- 1.3 microM; n = 2.3

247 ch suggests that phosphorylation-independent cooperative binding sets the basal level for glutamine s

248 lirin SH3 domain is unique, containing novel cooperative binding site(s) for intramolecular PXXP liga

249 We localized cooperative binding sites for En, with the homeodomain-c

250 olecules bind interdependently to three anti-cooperative binding sites on the trimeric PII protein an

251 Predictions of known cooperative binding sites show a 0.85 area under an ROC

252 e IL-2 adaptive region contains at least two cooperative binding sites where the binding of a first l

253 ntial motif arrangements for TBX5 and NKX2-5 cooperative binding sites, supported at the atomic level

254 oth ATP and ADP at two equivalent but highly cooperative binding sites.

255 We have found that the cooperative binding strength increases as the square of

256 s and modeling, we propose possible modes of cooperative binding tandem poly(C) motifs by the KH doma

257 emblies is a result of significant levels of cooperative binding that is present in both solvents.

258 which serves as the nucleation step for the cooperative binding that occurs at transiently exposed s

259 action with DevR approximately P resulted in cooperative binding, thereby enabling co-regulation of t

260 ite NFAT/AP-1 sites, which typically support cooperative binding, thus further reinforcing the need f

261 ucture of the RNA reveals the origins of the cooperative binding to 5S rRNA that has been observed fo

262 ormation that appears to facilitate pairwise cooperative binding to adjacent operator sites.

263 he CTD that is in pre-equilibrium to its non-cooperative binding to both dsDNA and ssDNA.

264 dependent cooperative binding, which relates cooperative binding to both the target concentration and

265 eved by interaction with protein partners or cooperative binding to closely separated Ets binding sit

266 Cooperative binding to DNA of tyrosine-phosphorylated ST

267 r, we show that self-association facilitates cooperative binding to DNA.

268 ediate Xis-Xis interactions required for its cooperative binding to DNA.

269 , intermolecular interactions as assessed by cooperative binding to DNA.

270 binding region of TNRC6B, we observed strong cooperative binding to dual sites, with almost no singly

271 miRNA-AGO2 complexes displayed little if any cooperative binding to dual sites.

272 ession by feedback modulation in response to cooperative binding to glycine.

273 on binding and is likely to be important in cooperative binding to KorB.

274 , one (Cdc20(M)) through well-characterized, cooperative binding to Mad2 and Mad3/BubR1 (forming the

275 reveal that NAA50 and HYPK exhibit negative cooperative binding to NAA15 in vitro and in human cells

276 e and cleave their cognate DNA sites through cooperative binding to opposite sides of the DNA substra

277 g to which Alx3 must act homodimerically via cooperative binding to P3-like sites is insufficient to

278 beta(1) concentration in a manner suggesting cooperative binding to PA.

279 involving direct hPAF1C-SII interactions and cooperative binding to RNA polymerase II.

280 th dsRNA translocation without unwinding and cooperative binding to RNA.

281 2 can homo- or heterodimerize, essential for cooperative binding to sequence-paired sites (SPS) locat

282 m occupancy of site I is required to trigger cooperative binding to site II and catalytic activation.

283 in a wild-type-like, salt-dependent shift in cooperative binding to ssDNA.

284 ties with the (SSB)35 mode displaying highly cooperative binding to ssDNA.

285 demonstrated two possibly distinct types of cooperative binding to substrates with Ets binding motif

286 element, multimeric forms are deficient for cooperative binding to tandemly duplicated elements, ind

287 o-terminal domain is largely dispensable for cooperative binding to the hb enhancer element, it is pr

288 r element, it is preferentially required for cooperative binding to the kni enhancer element.

289 tion is the formation of tetramers, allowing cooperative binding to their DNA response elements.

290 ize similar binding sites and participate in cooperative binding via protein-protein interactions wit

291 Cooperative binding was retained when the two sites were

292 Consistent with cooperative binding, we demonstrate that the Gal4-Tra1 i

293 re is an optimal stiffness k(a)(*) ~ 1/N for cooperative binding, where N is the number of residues.

294 Cooperative binding, whereby an initial binding event fa

295 stical mechanical model of density-dependent cooperative binding, which relates cooperative binding t

296 Cooperative binding with ELF4 increases the binding affi

297 carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in

298 of KLF4 on SMC marker genes is dependent on cooperative binding with pELK-1 (downstream activator of

299 ently to outcompete the downstream MrpC2 for cooperative binding with the upstream MrpC2.

300 as well as assembly kinetics, and can treat cooperative binding within one of the interacting molecu