ライフサイエンスコーパス: cooperative effect

1 er to dimer to trimer, signifying a positive cooperative effect.

2 binations of gif1 and grf mutations showed a cooperative effect.

3 creased the P(f) of T310I, consistent with a cooperative effect.

4 imer to trimer, signifying a strong positive cooperative effect.

5 he sites at -5.2, -5.5, and -6.1 kb elicit a cooperative effect.

6 e two subdomains independently, indicating a cooperative effect.

7 ation of chiral zinc-porphyrins (S-Zn) via a cooperative effect.

8 n, is both necessary and sufficient for this cooperative effect.

9 monium cation that suggests a supramolecular cooperative effect.

10 ery of cargo in living cells may result from cooperative effects.

11 mutant cycles, to determine the presence of cooperative effects.

12 ETO degradation, but without any additive or cooperative effects.

13 e overall effect, indicating the presence of cooperative effects.

14 provided new insights on these distinct but cooperative effects.

15 y a copy of sites III and IV abolishes these cooperative effects.

16 ding to the dehydratase domain, both through cooperative effects.

17 tic reactions on metal nanoparticles exhibit cooperative effects.

18 han the variable part thus suggesting strong cooperative effects.

19 porphyrin core and with negligible negetive cooperative effects.

20 rd small molecules that exploit metal-borane cooperative effects.

21 of different sizes, changes under different cooperative effects.

22 l/mol to the overall resistance, most of the cooperative effect (0.8 +/- 0.7 kcal/mol) being mediated

23 est path structure of the connectome enables cooperative effects, accelerating the spread of cascades

24 -pressure ice phases demonstrate significant cooperative effects, accounting for up to approximately

25 pRB is mutually dependent, and without this cooperative effect, activation steps previously shown to

26 rved cell cycle arrest likely results from a cooperative effect among the modulations of these genes

27 were activated simultaneously, suggesting a cooperative effect among these kinases.

28 Cooperative effects among residues of the reactive-site

29 SK and JNK signaling pathways and subsequent cooperative effects among the transcriptional factors CH

30 has been established for the first time for cooperative effects and cross talk between the C/EBP fam

31 creasing concentrations of ATP or PknK exert cooperative effects and enhance the inhibitory function

32 hat the SPO ligand demonstrates ligand-metal cooperative effects and plays a seminal role in the hete

33 This study also discloses cooperative effects and provides structural and mechanis

34 lity of phosphate to reduce the site to site cooperative effects and render each ligand binding site

35 linear relationship between the magnitude of cooperative effects and the number of mutant subunits.

36 sis on the stoichiometry of the interaction, cooperative effects, and their consequences for the inte

37 lication, Reynafarje and Pedersen claim that cooperative effects are an artifact caused by endogenous

38 interactions are additive, and no enthalpic cooperative effects are apparent.

39 The cooperative effects are most pronounced with medium chai

40 Modest cooperative effects are observed for the snugly fitting

41 We propose that these cooperative effects are propagated through a dynamic str

42 The role of cooperative effects arising from noncovalent attractive

43 st, high-pressure ice phases exhibit smaller cooperative effects (around 6%) and local structures tha

44 has to exclude templating, allosteric and/or cooperative effects as the latter are specific for indiv

45 lications in understanding allostericity and cooperative effects, as well as protein engineering and

46 lower frequency by some 50-70 cm(-1) due to cooperative effects associated with the central amide ac

47 in low concentrations of Mn2+, and apparent cooperative effects at higher Mn2+ concentrations result

48 ge of BCR:ligand affinities and involved: 1) cooperative effects at promoting early cell cycle progre

49 However, a cooperative effect between adjacent Hg atoms is observed

50 K1 and a kinase-inactive mutant of S6K1, the cooperative effect between PDK1 and protein kinase Czeta

51 erated HAM in segmented flow, achieved via a cooperative effect between rhodium (Rh)/N-Xantphos and a

52 Excited state analysis reveals a cooperative effect between the para-positioned amino gro

53 alone, showing an unexpected beneficial and cooperative effect between the vector and GDEPT.

54 A strong cooperative effect between these two transgenes induced

55 ciency were correlated with an unprecedented cooperative effect between two neighboring Nb centers on

56 It appears that a cooperative effect between two proximal functional group

57 To examine potential mechanisms for cooperative effects between bacterial and viral infectio

58 , reflecting both IFNgamma amplification and cooperative effects between both cytokines.

59 Addition of phalloidin did not alter cooperative effects between bound Ca2+ molecules in the

60 RNA virus assembly was created to model the cooperative effects between capsid proteins and genomic

61 olymerization results argue that substantial cooperative effects between catalytic sites are operativ

62 organoid and PDX models we could confirm the cooperative effects between chemotherapy and CDK4/6 inhi

63 t of the receptor within the surface reveals cooperative effects between clustering and binding that

64 These experiments document cooperative effects between constitutively activated tyr

65 s change with peptide length and predict new cooperative effects between distant residues in HLA-B07:

66 s from the selected TIMP-1 variants revealed cooperative effects between distant residues located on

67 have large dielectric response arising from cooperative effects between donor and acceptor units whe

68 Overall, the results corroborate cooperative effects between gelsolin-induced alterations

69 Mutational analysis revealed cooperative effects between glycans and residues at thes

70 Our results show both negative and positive cooperative effects between hydrophobic pocket interacti

71 More simply, however, cooperative effects between Lewis acids and organocataly

72 Exploiting cooperative effects between Na and Fe(II) centres presen

73 In this work we study cooperative effects between neighboring cells of differe

74 of applied bias, suggesting the presence of cooperative effects between optical and electrical stimu

75 ) causes endothelial NO* release mediated by cooperative effects between PI 3-kinase/Akt-dependent eN

76 everal Raman and ROA bands also clearly show cooperative effects between the mismatch and pyrimidine-

77 This special cooperative effect can only be realized, if the ROS-prod

78 Rank suggests that explicit modeling of gene cooperative effects can greatly improve biomarker identi

79 The analysis reveals that cooperative effects do not control the fragility of such

80 However, previous studies have suggested cooperative effects during the peptide binding process.

81 These cooperative effects exhaust previously active O atoms ab

82 l to the protein concentration, suggesting a cooperative effect for DNA cleavage.

83 sociate with each other and exert a positive cooperative effect for gene regulation.

84 with enhanced an ionic liquid effect through cooperative effects for the substrate activation and fur

85 Such tags hold great promise, through cooperative effects, for controlling the stability of bi

86 Dimers harboring two mutations with opposite cooperative effects had different allosteric properties

87 tices have also been reported(10,11), but no cooperative effects have been observed and interactions

88 er identification methods that consider gene cooperative effects implicitly or explicitly, and propos

89 omplexes [3.12] and [4.12] showed a negative cooperative effect in both cases.

90 The cumulative cooperative effect in longer H-bonded chains reaches an

91 tert-butoxy)siloxide ligands induces a large cooperative effect in the reduction of CO2.

92 -component infusion evidently results from a cooperative effect in which charge is generated on g-C3N

93 IL-1alpha and LIF display cooperative effects in activating EMH and are both up-re

94 concept is illustrated via investigation of cooperative effects in an extended system of compartment

95 motherapeutic agents, the VAs show unequaled cooperative effects in chemotherapy and immunotherapy in

96 hat simultaneous HER2/VEGF blockade may have cooperative effects in gastroesophageal adenocarcinomas.

97 the same monomer side chain produced optimal cooperative effects in improving the macroscopic adhesio

98 of the mechanism and suggest the origins of cooperative effects in meta-substituted aryl oxazolines.

99 tgun scanning should be useful for assessing cooperative effects in other protein-protein interaction

100 , phosphate buffer significantly reduces the cooperative effects in serine binding without affecting

101 h's crust, were found to exhibit substantial cooperative effects in transamination reactions catalyze

102 early half of these neuronal trios displayed cooperative effects in which the cortical discharge prob

103 n between clones is considered; there are no cooperative effects included.

104 DNA with similar affinity, but the negative cooperative effect is eliminated.

105 rminal deletion enzymes, suggesting that the cooperative effect is mediated via N-terminal intersubun

106 Obtaining insight into microscopic cooperative effects is a fascinating topic in condensed

107 lated electron transfers, and the associated cooperative effects lead to the formation of O(-) radica

108 Both AQP1 mutants exhibit a surprising cooperative effect leading to a reduction in the free-en

109 - than in the RasTg group suggests that this cooperative effect may be in part explained by increased

110 have suggested that strong, but short-range cooperative effects may occur in H-bond chains.

111 The strong cooperative effects observed between anti-Ig and TGF bet

112 The theory also predicts the cooperative effects observed in the calcium loading of T

113 This negative cooperative effect of 17b may provide insight into appro

114 its effect on cell size and number, and the cooperative effect of Akt on oncogene-driven proliferati

115 The cooperative effect of amine-templating and doping by Sn

116 eal carcinomatosis, was used to evaluate the cooperative effect of an antiangiogenic gene therapy com

117 h regulators were abundant (i.e., a negative cooperative effect of ATP x CTP).

118 The cooperative effect of B-agonists (isoproterenol) and c-A

119 ion of troponins that bound Ca2+, implying a cooperative effect of bound Ca2+ on cross-bridge cycling

120 linear clusters or chains, stabilized by the cooperative effect of chemical bonds with the substrate

121 spirocyclization of naphthols enabled by the cooperative effect of chiral dual hydrogen-bond donors (

122 but many behavioral studies find an apparent cooperative effect of D1 and D2 receptors in the nucleus

123 The adsorption is driven by the cooperative effect of divalent metal ion condensation al

124 hysiologic testing is critical in ensuring a cooperative effect of drug and implantable cardiovascula

125 S6K activation by EGF and contributes to the cooperative effect of GPCRs on p70S6K activity and cell

126 the antiviral activity of nAbs and suggest a cooperative effect of human monoclonal antibodies and IF

127 Hence, it is the cooperative effect of inactivation of both pRB and p53 t

128 ng affinities between the proteins, but to a cooperative effect of interactions in the TCR-SEA-MHC cl

129 In a nuclear factor-DNA binding assay, the cooperative effect of mmLDL and LPS costimulation on c-J

130 enhanced electron correlations driven by the cooperative effect of moire-confined strain and localiza

131 gratory front-back polarity emerges from the cooperative effect of myosin IIA (MIIA) and IIB (MIIB) o

132 The cooperative effect of only four amino acidic units is su

133 suggest that the reaction is enabled by the cooperative effect of organic nitriles and electron-defi

134 Notably, a cooperative effect of ortho-substituents in the case of

135 Therefore, these results suggest a cooperative effect of p12 and CA during the early events

136 We emphasize the cooperative effect of pressure and rare earth size by de

137 awa-Sachdev-Ye-Kitaev model by considering a cooperative effect of quantum critical fluctuation and d

138 cognized and suggests an explanation for the cooperative effect of Raf-1 and Rho family proteins on c

139 lation of CoQ0 is described by employing the cooperative effect of Sc(OTf)(3) and Hantzsch ester.

140 finity interaction that is the result of the cooperative effect of single motifs simultaneously bindi

141 the transient transfection assay, a positive cooperative effect of SRF and TEF-1 was observed when DN

142 uperposition model for the evaluation of the cooperative effect of substituents in homo- and heterosu

143 ical reduction of Erk activity inhibited the cooperative effect of TGFbeta and ErbB2 on migration and

144 firing of a given place cell is primarily a cooperative effect of the activity of its neighbors on t

145 region of the IL-8 gene revealed a positive cooperative effect of the binding sites for AP-1 and NF-

146 A positive cooperative effect of the binding sites for the transcri

147 p of the reaction of the N-oxide is due to a cooperative effect of the C-H Bronsted acidity, the stre

148 tion between gp120 and its receptors and the cooperative effect of the CCR5 binding site on the CD4 b

149 superlattices is shown to be a result of the cooperative effect of the entropy-driven crystallization

150 Our results prove the existence of a cooperative effect of the metal and the ligand in severa

151 ws an increased stability resulting from the cooperative effect of the multiple pi-stacking interacti

152 In the post-diauxic phase, the cooperative effect of the pheromone activated mitogen-ac

153 radient in the negative effect, suggesting a cooperative effect of the three CRX elements.

154 DFT studies support the presence of a cooperative effect of the two metal centers in the trans

155 s efficiently (Kd = 2 x 10(-8) M), showing a cooperative effect of the two motifs.

156 with respect to calix[6]-host 1a, due to the cooperative effect of their two subcavities.

157 The absence of the cooperative effect of these cytokines on macrophages, ho

158 The cooperative effect of these two classes of inhibitors on

159 Consistent with the cooperative effect of TSA and RA, coaddition of the two

160 served during EBOV infections results from a cooperative effect of two or more individual IRADs.

161 st that substrate activation arises from the cooperative effect of vicinal boronic esters during the

162 improvement in kcat is likely because of the cooperative effects of additional substitutions located

163 The cooperative effects of AKT, ERG, and androgen receptor i

164 hepatitis viral proteins could contribute to cooperative effects of alcohol consumption and viral hep

165 n the sensor and hydrogel host resembles the cooperative effects of an apoenzyme and cofactor: the ho

166 humoral immune responses that depends on the cooperative effects of B cells and T cells.

167 The results support a model in which cooperative effects of both Ag-DNA ligation and variatio

168 ervations provide evidence for near-neighbor cooperative effects of both rigor and cycling cross-brid

169 les larger property enhancement owing to the cooperative effects of both the increased cross-link den

170 ostatic interactions and it is proposed that cooperative effects of both water structure and surfacta

171 filament MgATPase rate and did not eliminate cooperative effects of Ca2+ binding.

172 tal-to-insulator transition is linked to the cooperative effects of changes in the V-O bond length, l

173 first quantitative framework for identifying cooperative effects of chromatin modifications on protei

174 Cooperative effects of cmpd-6 augment the B-blockade pro

175 This unusual phenomenon is caused by cooperative effects of crystallization, evaporative flow

176 efects of dE2F1-depleted cells depend on the cooperative effects of dE2F2 and DACAPO (DAP), an inhibi

177 hydrogels in physiological buffer driven by cooperative effects of electrostatic interaction, van de

178 important delta(H)-determinant, longer-range cooperative effects of extended hydrogen networks make s

179 However, the cooperative effects of fluid shear stress and matrix sti

180 cooperation network to explicitly model the cooperative effects of gene combinations.

181 Cooperative effects of genetic alterations are frequentl

182 pitopes.This study illustrates how potential cooperative effects of HCV bNAbs can be utilized by stra

183 By the cooperative effects of hydrophobic interaction and ionic

184 tentiation of Treg responsiveness to IL-2 by cooperative effects of IL-6 and IL-1, both of which are

185 c transformation in mice was associated with cooperative effects of JAK2-V617F and Hippo kinase inact

186 In this study, we explore the cooperative effects of ligand binding and Magnesium inte

187 The cooperative effects of ligand binding appear to be minim

188 Notch3 inhibits CXCR4 expression through the cooperative effects of miR-139-5p and miR-150-5p, thus i

189 ion within individual NCs; this supports the cooperative effects of mixed cation-anion doping in shif

190 Multibody potentials accounting for cooperative effects of molecular interactions have shown

191 radical character and provide insights into cooperative effects of multimetallic centers in tuning P

192 nhibitors should take into account potential cooperative effects of multiple kinase mutations, and th

193 ortening is not the result of changes in any cooperative effects of myosin on Ca2+ binding to the thi

194 ls suggest that this patterning results from cooperative effects of Nf1 loss in glial cells and the a

195 ance in prostate cancer, we investigated the cooperative effects of Pim kinase inhibition with ABT-73

196 r is to modulate behaviors by inhibiting the cooperative effects of postsynaptic D1 and other D2 clas

197 The results suggest that the cooperative effects of PPARgamma- and RXR-specific ligan

198 ptor (alpha(1)-AR) pathway that requires the cooperative effects of protein kinase (PK)Cepsilon and P

199 regulation, for the redox reaction, and for cooperative effects of serine binding.

200 To characterize the allosteric, cooperative effects of serine, we identified W139G PGDH

201 elated activity between interneurons, by the cooperative effects of shared synaptic depolarization an

202 Herein we report the cooperative effects of targeting these distinct pathways

203 n the desymmetrizing reaction arose from the cooperative effects of the Ir(I) species and the HypPhos

204 siology of mastocytosis and demonstrated the cooperative effects of the KIT and Hh oncogenic pathways

205 r microstructure is found to be based on the cooperative effects of the normal and thermal diffusion

206 gene transcription, which is mediated by the cooperative effects of the transcription factors, HIF-2

207 The cooperative effects of thrombin on Akt/p70S6K phosphoryl

208 The cooperative effects of two or more metal centers in mult

209 ditive, and significant positive or negative cooperative effects often exist.

210 s shown to determine whether the substituent cooperative effect on a property is of an enhancing or d

211 s not increased by c-Abl inhibitors, and the cooperative effect on ASM relaxation resides in further

212 type receptors in the shell of the ACB had a cooperative effect on DA-mediated reward processes.

213 We observed a striking cooperative effect on focus-forming ability when Galpha1

214 A significant cooperative effect on lifespan is observed between asm-3

215 ular pattern (PAMP) stimulation had a strong cooperative effect on macrophage activation and inflamma

216 The rate of decay of the cooperative effect on most properties, including the (hy

217 Bcl-2, caspase-3, P53, and survivin have a cooperative effect on progression of bladder cancer.

218 variations, we observed the influence of the cooperative effect on single base pair mismatches.

219 sfection of Smad2 and Runx2 constructs had a cooperative effect on TGF-beta 1-stimulated collagenase-

220 , and botrocetin had the expected positively cooperative effect on the binding of VWF A1 to GPIbalpha

221 from RET and regulate HIF-1, abrogated their cooperative effect on the CA9 promoter.

222 rough their electrostatic interaction have a cooperative effect on the proton-transfer rate.

223 We propose a model in which the Tax/Ets1 cooperative effect on the PTHrP P2 promoter is based on

224 the presence of both ligands can result in a cooperative effect on the transactivation of target gene

225 ecific CD8+ T cell numbers and resulted in a cooperative effect on tumor regression, with apparent cu

226 the receptor from which it exerts negatively cooperative effects on [3H]spiperone binding to the comp

227 ated phosphorylation of C0-C2 eliminated the cooperative effects on actin flexibility and modestly in

228 polize the translational machinery to elicit cooperative effects on cell growth, cell cycle progressi

229 idence for an alternative mechanism based on cooperative effects on cell motility.

230 anced matrix stiffness, and together exerted cooperative effects on cellular modulation of matrix mec

231 interfere with hydrogen bond formation show cooperative effects on complex stability and affinity.

232 and protein kinase A pathways may occur via cooperative effects on GR-mediated gene transcription.

233 s showed that phenformin and PLX4720 exerted cooperative effects on inhibiting mTOR signaling and ind

234 results suggest that the effector exerts its cooperative effects on MDZ metabolism through simultaneo

235 ffect OATP1B1 transport function, indicating cooperative effects on OATP1B1 by concurrent PTMs.

236 tions and the N52I mutation, consistent with cooperative effects on protein folding and stability bei

237 alone, suggesting that Galphas and Hrs have cooperative effects on regulating EGF receptor degradati

238 Increasing HER2 density thus has cooperative effects on T cells-it increases both CAR exp

239 nding to the competitive site and positively cooperative effects on the binding of the modulator to t

240 The cooperative effects on the rates of intrafilament motion

241 Cooperative effects on the reactivity of the complexes w

242 reover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated

243 Cooperative effects on Zn(II) affinities stemming from t

244 Cooperative effects promote the structural sequestration

245 Such cooperative effects provide a means of manipulating the

246 These cooperative effects rely on key aromatic residues, and a

247 To test whether there is a cooperative effect resulting from the two subunits being

248 The cooperative effect seen at low doses switches to antagon

249 which displaced each other and displayed no cooperative effects, several other combinations resulted

250 Such cooperative effects suggest a number of applications tha

251 hydrophobic contact also contributes to the cooperative effect, suggesting a role for all energetic

252 Ets1 interaction also inhibited the Tax/Ets1 cooperative effect, suggesting that the interaction betw

253 ns (V82A/I84V/M46I/I54V) only showed a small cooperative effect, suggesting that the mutations at the

254 The mechanism by which the present cooperative effects take place is investigated, as is th

255 or anionic species is attributed to a strong cooperative effect that arises from the properly positio

256 ten result in the observation of significant cooperative effects that afford different rates and sele

257 into the origins of the allosteric negative cooperative effects that are transmitted over long dista

258 Two cross-checking analyses show cooperative effects that cause individual hydrogen bond

259 aracteristic of the binding site accentuates cooperative effects that permit mutations in distal resi

260 In addition to exhibiting a strong cooperative effect, the Tgfbeta receptor inhibitor bypas

261 t to the aspect ratio of the dye, allowing a cooperative effect to increase their overall average ali

262 r influenza hemagglutinin FP, i.e., it has a cooperative effect versus the peptide/lipid ratio, suppo

263 the PTHrP promoter was mutated, the Tax/Ets1 cooperative effect was dramatically decreased.

264 k functional CD8+ T cells, suggesting that a cooperative effect was exerted by the combination of neu

265 In such complexes, a peripheral cooperative effect was found, alleviating the excess of

266 Also, a clear cooperative effect was observed for the taxoid-camptothe

267 No cooperative effect was observed with GFAP-hCDK4; Rb+/- m

268 To investigate these cooperative effects, we cultured bovine aortic ECs on hy

269 Cooperative effects were also evident in CheA binding an

270 Importantly, the mmLDL and LPS cooperative effects were evident at a threshold LPS conc

271 Strong cooperative effects were observed in which the photoreac

272 Cooperative effects were observed with local radiotherap

273 icity of [2]+ arises from both Coulombic and cooperative effects which lead to formation of a B-F-->P

274 reinforce the interaction strength through a cooperative effect, which can lead to large stable oligo

275 heterogeneous diseases often exhibit strong cooperative effects, which implies that a set of genes m

276 l 30 amino acids of p53 does not affect this cooperative effect with DNA-damaging agents.

277 y, whereas the S domain is important for the cooperative effect with p54.

278 this study, we primarily investigated DMC's cooperative effect with tumor necrosis factor-related ap

279 Ongoing translation controls these cooperative effects, with TF-accelerated folding dependi

280 These results suggest a strong cooperative effect within poly-Ps that enhances their st

281 t appears that the pKa of D96 is raised by a cooperative effect within the purple membrane.

282 d and, using hotspot descriptors which model cooperative effects within hotregions, we show how the c