ライフサイエンスコーパス: cooperativity

1 to the mechanism of nanoscale macromolecular cooperativity.

2 diates the allostery underlying the negative cooperativity.

3 the molecular underpinnings of this enhancer cooperativity.

4 reased calcium sensitivity and thin filament cooperativity.

5 providing further support of myosin-gelsolin cooperativity.

6 er tetramer and the magnitude of the binding cooperativity.

7 ooperative DNA elements, and characterize TF cooperativity.

8 tributing to a salt-driven switch in binding cooperativity.

9 e that the two substrates bind with negative cooperativity.

10 y the same chromatin region through indirect cooperativity.

11 his naturally leads to rate enhancements and cooperativity.

12 nearest-neighbor versus non-nearest-neighbor cooperativity.

13 pment targeting the intersection of oncogene cooperativity.

14 p that further demonstrates specific pol-exo cooperativity.

15 transcribed by indirectly enhancing folding cooperativity.

16 ll constriction is not dependent on assembly cooperativity.

17 able to its C2A domain, suggesting a lack of cooperativity.

18 S revealed that dUMP substrate binds without cooperativity.

19 al modes differing in occluded site size and cooperativity.

20 avior including affinity, stoichiometry, and cooperativity.

21 tween different supercoiled states with high cooperativity.

22 modes that differ in occluded site size and cooperativity.

23 non-specific DNA binding and protein-protein cooperativity.

24 process that is facilitated by metal-ligand cooperativity.

25 f tissues proved highly sensitive to loss of cooperativity.

26 ssic biochemical principles of allostery and cooperativity.

27 portant but poorly characterized model of TF cooperativity.

28 hat may be mistakenly attributed to negative cooperativity.

29 the development of a comprehensive model of cooperativity.

30 etry consistent with the absence of negative cooperativity.

31 esidence time, high specificity, and tunable cooperativity.

32 c activity, albeit with altered kinetics and cooperativity.

33 a-elements is obscured by the global folding cooperativity.

34 or allosteric modulators on the magnitude of cooperativity.

35 mate does not enhance these nearest-neighbor cooperativities.

36 s with higher Ca(2+) affinities and/or lower cooperativities.

37 in functional affinity (5000-fold increase), cooperativity (100-fold increase), and a novel action to

38 void and exploiting collective enhancement, cooperativities ~400 or more should be achievable.

39 trast, partitions more of this energy toward cooperativity, achieving a Hill coefficient of 2.3, but

40 g motions of the enzyme, underlie allosteric cooperativity along the kinase's cycle.

41 vity values all reside on a ridge of maximum cooperativity along this landscape that allows for both

42 ligands occurs with high positive allosteric cooperativity (alpha > 40), and the ligand is an effecti

43 cores) occurs with high negative allosteric cooperativity (alpha ~ 10(-3)-10(-4)).

44 d disease-associated mutations that suppress cooperativity alter the number and/or relative populatio

45 , bind in the (SSB)(65) mode but show little cooperativity, although cooperativity increases at lower

46 hA displays homotropic positive and negative cooperativity among its four protomers.

47 ium, we introduce a language of higher-order cooperativities and show how it can rigorously quantify

48 s, much less is known about the influence of cooperativity and conformational dynamics.

49 h has been discovered whereby reversible M-L cooperativity and coordination induced bond weakening li

50 lar (chelate) cooperativity and interannular cooperativity and discuss approaches to quantify them th

51 ds to the previously reported Ca(2+)-binding cooperativity and dominant negative effect of mutation o

52 as a model system to investigate the role of cooperativity and dynamics in PDZ ligand specificity.

53 ional switch in FtsZ that underlies assembly cooperativity and enable treadmilling of protofilaments,

54 r results to theory reveals how higher-order cooperativity and energy expenditure impact boundary loc

55 main arrangements are not linked to negative cooperativity and hemiphosphorylation.

56 binding of the agonist CP55940 with positive cooperativity and inhibiting binding of the inverse agon

57 riplet or triangle motifs, have been tied to cooperativity and integration.

58 ric) cooperativity, intramolecular (chelate) cooperativity and interannular cooperativity and discuss

59 nd/or electrons as expressed by metal-ligand cooperativity and ligand redox-activity strongly stimula

60 DHT monomers for copolymerization with high cooperativity and low dispersity indexes.

61 emotional valence with others, can allow for cooperativity and social bonding between individuals.

62 s extend our understanding of the origins of cooperativity and stability in protein folding, includin

63 The link between allosteric cooperativity and template-directed synthesis has been i

64 amework with which we address the origins of cooperativity and the mechanism of activated, hyperinsul

65 DNA-binding domain regulates the DNA binding cooperativity and transcriptional activity of p53.

66 e interface residues bind ssDNA with reduced cooperativity and with an altered distribution of DNA bi

67 elineate DNA-sequence determinants for their cooperativity, and show how PU.1 affinity correlates wit

68 However, the energetics of cooperativity are complicated by solvent effects and the

69 Differences in both K(D)'s and cooperativity are observed between detergent micelles an

70 ent, and a few pathways and a high degree of cooperativity are observed in both the experiment and si

71 How such strong cooperativity arises from a multitude of individual inte

72 function of loading, as a result of negative cooperativity arising from electronic effects within the

73 es to nanoparticles and it expresses binding cooperativity as the cumulative result of pairwise resid

74 action systems, metal-ligand and metal-metal cooperativity, as well as modeling complex catalytic sys

75 e or from a mixture of positive and negative cooperativity at distinct genomic loci.

76 kedly reduce oxygen affinity and even confer cooperativity, because an ancient linkage between the ox

77 This finding is consistent with cooperativity between actin filament severing by myosin-

78 CaM regulation of the channels, facilitating cooperativity between adjacent subunits and regulating f

79 ting anesthetic binding effects and positive cooperativity between anesthetic binding sites.

80 We find that the cooperativity between Cbf1p dimers varies sinusoidally w

81 The molecular viewpoint on cooperativity between crystallization modifiers provides

82 We also found positive cooperativity between EF-4, EF-3 and EF-2, EF-1 and allo

83 rvations, we suggest that UvrA uses negative cooperativity between its ATPase sites that is gated by

84 s intramolecular interactions and functional cooperativity between its N- and C-terminal domains that

85 trate the utility of DISC algorithm to probe cooperativity between multiple binding events in the cyc

86 Our data highlight the importance of cooperativity between multiple sensing networks to expos

87 er the degree of electrophysiological gating cooperativity between Nav1.5 alpha-subunits.

88 Across biological systems, cooperativity between proteins enables fast actions, sup

89 Thermodynamic analyses revealed energetic cooperativity between residues in distinct specificity s

90 We also find cooperativity between structural mimicry and a crucial p

91 cally disordered segments, and allostery and cooperativity between subunits in biological systems res

92 aracterization reveals that the enzyme shows cooperativity between subunits, and mutagenesis and stru

93 his mechanism highlights a novel paradigm of cooperativity between SWI/SNF and PRC1.

94 ent axons and postsynaptic neurons, boosting cooperativity between synaptic inputs.

95 ferent axon fibre polarization, which boosts cooperativity between synaptic inputs.

96 low kinetic measurements show differences in cooperativity between Syt-1 and Syt-7: Syt-1 C2AB dissoc

97 ll-free system that demonstrates interdomain cooperativity between the ligand (LBD) and DNA binding d

98 hout the entire domain suggesting structural cooperativity between the mutated residues.

99 e mechanism of allostery underlying negative cooperativity between the two agonists glutamate and gly

100 P binding, with a focus on quantification of cooperativity between the two substrate binding events.

101 ic improvement in the activity signifies the cooperativity between Ti and W and indicates that the ke

102 The cooperativity between two Co(II) sites within the define

103 Instead nucleosome sliding requires cooperativity between two INO80 complexes that monitor D

104 e Hill equation, which provides a measure of cooperativity but no insights into its origin.

105 RC) 1 and 2 components indicates substantial cooperativity, but distinguishes a dominant role for PRC

106 ing M-domain/C2) similarly exhibited reduced cooperativity, but not as reduced as by phosphorylated C

107 assembly arises through positive or negative cooperativity by extrinsic G3BP1-binding factors that st

108 crystal resonator capable of achieving large cooperativity C and small effective bath occupancy n(b),

109 bath occupancy n(b), resulting in a quantum cooperativity C(eff) = C/n(b) > 1 under continuous-wave

110 king advantage of the large piezo-mechanical cooperativity (C(em) ~7) and the enhanced optomechanical

111 In addition, a non-nearest-neighbor high cooperativity can also occur in the (SSB)(65) mode on lo

112 This cooperativity can arise from a chromatin looping-mediate

113 es are approximately equal, and the negative cooperativity can be attributed to faster dissociation o

114 The transition pH and cooperativity can be controlled through the number of hi

115 finger repressor library, whose affinity and cooperativity can be rationally engineered.

116 rodent cortical neurons confirm that channel cooperativity can robustly induce graded persistent acti

117 nding sites and does not necessarily require cooperativity, clustering, or binding site overlap.

118 Cleavage was found cooperative with a cooperativity coefficient n = 2.3, suggesting that the m

119 Designed binding interaction cooperativity, confirmed by native mass spectrometry, ma

120 We therefore propose that ion channel cooperativity constitutes an efficient cell-intrinsic im

121 This cooperativity converts the BC into the first example of

122 the inverse agonist SR141716A with negative cooperativity, demonstrated via radioligand binding stud

123 This filament-based mechanism of enhanced cooperativity demonstrates how the widespread phenomenon

124 order structures with a rate and a degree of cooperativity dependent on pH and Ca(2+) concentration.

125 ), exhibit both synergistic and antagonistic cooperativity depending on the inhibitor combination and

126 es that can show either negative or positive cooperativity, depending on the guest.

127 st dissociation proceeds in a nonuniform and cooperativity-driven manner, which disfavors nondesensit

128 the hair follicle matrix, with AP-1 and TGFB cooperativity driving nMRTF activation.

129 e environments that induce varying levels of cooperativity during growth.

130 Cooperativity enhances the responsiveness of biomolecula

131 ntify two consecutive waves of tight genetic cooperativity enriched in deregulated genes (critical ph

132 ve a large interaction-to-dissipation ratio (cooperativity exceeding 100), reaching the regime of str

133 ant contribution to the origin of the unique cooperativity exhibited by these systems.

134 However, whether cooperativity exists between the different modes and the

135 r drug banks, along with the availability of cooperativity factors from radioligand displacement expe

136 n, using pyridine as a competing ligand, and cooperativity factors were confirmed by NMR spectroscopy

137 hes to quantify them thermodynamically using cooperativity factors.

138 design of systems that exploit metal-ligand cooperativity for electrocatalysis where the electrochem

139 heptamerizes through concentration-dependent cooperativity for maximal ATPase activity and upon hepta

140 e, the kinase exhibits positive and negative cooperativity for substrate and nucleotide binding and p

141 regulation, greatly exceeding the limits of cooperativity for the CTPS2 tetramer alone.

142 eased kinase activity, altered affinity, and cooperativity for the substrates, and, surprisingly, onl

143 Cofilin binds actin filaments with positive cooperativity, forming clusters of contiguously bound co

144 s of 200-300 nm YaaA binds DNA with positive cooperativity, forming multiple shifted species in elect

145 We therefore propose that the superior cooperativity found in BEAT interfaces is the key driver

146 The cooperativity found in ordered supramolecular polymers l

147 affinity) receptor internalization and away (cooperativity) from the ERK1/2 phosphorylation pathway,

148 This cooperativity has been found to be a fundamental aspect

149 and the role of the IDL in nearest-neighbor cooperativity has not been probed.

150 This novel demonstration of cooperativity highlights the potential possibilities for

151 r of intermediates and the degree of folding cooperativity, important issues that should be considere

152 The metal-ligand cooperativity in [Fe(tpyPY2Me)](2+) drives the electroch

153 ters essential for deciphering mechanisms of cooperativity in a wide range of ligand-regulated homo-o

154 cterization evidences a special metal-ligand cooperativity in accommodating the required oxidative eq

155 centrations and proximities as well as their cooperativity in activating CO(2) and dissociating hydro

156 we present direct measurements of energetic cooperativity in an experimental system in which the geo

157 ity for ATP driving motor rotation, negative cooperativity in ATP hydrolysis, and the energetic requi

158 al modeling, we unambiguously demonstrate no cooperativity in autophosphorylation of CpxA despite its

159 Nonphosphorylated p53 exhibits positive cooperativity in binding DNA as a tetramer.

160 This bis-fullerene adduct exhibits different cooperativity in binding pairs of anions from the fuller

161 and EP4 receptor agonism exhibited positive cooperativity in both chronic G(s)-mediated signaling an

162 Our in vitro study validates protein-lipid cooperativity in constricting membrane tubules.

163 he presence of sequence-dependent asymmetric cooperativity in DNA.

164 itration studies to examine nearest-neighbor cooperativity in each binding mode and between binding m

165 t individual cellular dynamics and cell-cell cooperativity in evolving human immune responses remain

166 gene deregulation on the dynamics of genetic cooperativity in HD remains poorly understood.

167 robust experimental system for investigating cooperativity in HK autophosphorylation and offers a use

168 insight into TS allosteric function, binding cooperativity in human TS is examined here.

169 larly puzzling has been the apparent lack of cooperativity in hydrolysis of the ATP in each protomer.

170 ur study identifies a source of the negative cooperativity in IGF1 binding to IGF1R and reveals the s

171 highlight the importance of heterobimetallic cooperativity in N(2) activation, and establish FLPs in

172 Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engi

173 th and the role of membrane localization and cooperativity in nucleating assembly.

174 correlated fashions, despite no inclusion of cooperativity in our models.

175 ist-dependent deactivation because of strong cooperativity in proton binding.

176 e, lncRNA-MAP3K4 and MAP3K4 knockdown showed cooperativity in reducing inflammation in endothelial ce

177 l turns, pointing to a substantial degree of cooperativity in SAH stability.

178 etwork model of temporal dynamics of genetic cooperativity in the brain of HD knock-in mice (allelic

179 highly dynamic temporal features of genetic cooperativity in the brain of Hdh mice where a 2-step lo

180 , but not E402, was critical for high signal cooperativity in the receptor array.

181 covered that chaperones display a remarkable cooperativity in their interactions with numerous client

182 Irreversible HE mutations led to cooperativity in virus swarms with low-affinity S minori

183 est that SSB likely binds to ssDNA with high cooperativity in vivo.

184 mGluR2/7 shows cooperativity in which an unliganded subunit greatly enh

185 s (rate enhancement, switching, and negative cooperativity) in how the receptor participates in signa

186 solutions to the thermodynamic conditions of cooperativity, in contrast to the common view of a finel

187 In contrast, cooperativity increased substantially (kappa = 0.68) whe

188 mode but show little cooperativity, although cooperativity increases at lower [NaCl] for wild-type SS

189 roquinoline compounds, which showed negative cooperativities instead.

190 We propose a systematic categorisation of cooperativity into cooperative aggregation, intermolecul

191 ive aggregation, intermolecular (allosteric) cooperativity, intramolecular (chelate) cooperativity an

192 We show that stoichiometry and cooperativity is a function of DNA length and verify the

193 Metal ligand cooperativity is a powerful strategy in transition metal

194 Upon phosphorylation of Thr55, cooperativity is abolished and p53 binds initially to co

195 pMHC:TCR interaction it is evident that this cooperativity is accomplished by increasing the kinetic

196 filin clusters, suggest that maximum binding cooperativity is achieved when 2 cofilins occupy adjacen

197 Part of the cooperativity is due to association between coiled-coil

198 roup element compounds, however, metal-metal cooperativity is much less explored.

199 Furthermore, positive cooperativity is observed under conditions where the T c

200 fullerene-free parent: in one case, positive cooperativity is observed, while in another all binding

201 This negative cooperativity is often correlated with an asymmetric dom

202 Binding cooperativity is often mediated by specific protein-prot

203 It is easier to activate with cAMP, and the cooperativity is reduced.

204 We propose that this cooperativity is the intrinsic requirement of the CRISPR

205 Absent cooperativity, it is unclear how HIV can temporarily rem

206 ence of extracellular Ca(2+), we observed no cooperativity (kappa < 0.1), whereas in 1.8 mm external

207 native channels showed substantial negative cooperativity (kappa = 0.27).

208 aamine-functionalized frameworks that retain cooperativity, leading to the potential for exceptional

209 revealed amino acid interaction networks and cooperativity, linked positive cooperativity to structur

210 ular, to those that can undergo metal-ligand cooperativity (MLC) at the catalyst.

211 ake the fascinating finding that a novel p53 cooperativity mutation devoid of DNA binding results in

212 ill model yielded n(Hill) ~2.9, near maximal cooperativity (n(Hill) = 4).

213 The system is pH-dependent, and inversion of cooperativity (negative to positive) occurs by increasin

214 ver, in contrast to the non-nearest-neighbor cooperativity observed on longer ssDNA, glutamate does n

215 Triazolodiazepine PROTACs exhibited positive cooperativities of ternary complex formation and were mo

216 on from gamma-TuRC occurs efficiently with a cooperativity of 4 alphabeta-tubulin dimers.

217 classical surfactants in that they have low cooperativity of aggregation and work at molar concentra

218 c exchange processes underlying the negative cooperativity of binding of "monovalent" ligand tafamidi

219 vealed a dependence of both the affinity and cooperativity of binding on [Mg(2+)], which explained th

220 rin nanoring, in keeping with their negative cooperativity of binding.

221 tration calorimetry (ITC) to investigate the cooperativity of Ca(2+) binding to CALX-CBD1.

222 We also assess the cooperativity of domain insertion, by expressing the ind

223 Cooperativity of E-prostanoid receptor subtypes in regul

224 the polymerization properties and impair the cooperativity of FtsZ assembly in vitro.

225 without the negative ATP binding inter-ring cooperativity of GroEL-GroES.

226 modifiers is expected, but the antagonistic cooperativity of haematin inhibitors is not reflected in

227 nt with the experimentally measured negative cooperativity of ketamine binding to GLIC.

228 Neither did high cooperativity of MrpC and FruA binding upstream of the d

229 art, without altering calcium sensitivity or cooperativity of myofibers.

230 Our results show positive cooperativity of NTD up/down equilibria between neighbor

231 Although both affinity and cooperativity of oxygen binding to Hb affect tissue oxyg

232 phorylation and acetylation) and DNA binding cooperativity of p53.

233 actions with solvent molecules determine the cooperativity of phase transitions.

234 Owing to the cooperativity of protein structures, it is often almost

235 First, the high cooperativity of S3D cofilin generates fewer boundaries

236 re, we investigate the stability and folding cooperativity of the C-terminal domain of the ribosomal

237 The modularity and cooperativity of the control elements, coupled with the

238 iments, including expected rank order in the cooperativity of the folding transition and stability-de

239 ating I98A mutation apparently increased the cooperativity of the loss of folded-state peak intensity

240 Intricate cooperativity of the metal was observed with different p

241 s remain, such as a lack of consensus on the cooperativity of thiamine pyrophosphate (TPP) binding in

242 ined directly the dissociation constants and cooperativity of TPP binding and provide the first compr

243 equired for rapid synchronization and Ca(2+) cooperativity of vesicle release.

244 s displays high "unlimited" nearest-neighbor cooperativity (omega(35)), forming long protein clusters

245 gher [NaCl] (>200 mM) and displays "limited" cooperativity (omega(65)), forming only dimers of tetram

246 find significant intermode nearest-neighbor cooperativity (omega(65/35)), with omega(65) << omega(65

247 o which the system is weighted toward higher cooperativity or higher affinity.

248 ons in calcium sensitivity of the myofibers, cooperativity, or calcium-ATPase activity in the myofibe

249 tigated mAb, unfolding is characterized by a cooperativity parameter sigma ~6 x 10(-5) and a Gibbs fr

250 However, current methods to measure cooperativity parameters have been laborious and therefo

251 an informative tool for quantifying binding cooperativity, particularly in cases in which bound inte

252 ositions results in analogues with divergent cooperativity profiles.

253 identified several genomic regions where the cooperativity promoting sequence pattern is co-bound by

254 illisecond motions known to be essential for cooperativity provide a dynamical framework with which w

255 Forced expression of all four strands show cooperativity, reducing cell cycle pathways and inhibiti

256 Here, we suggest that Hb affinity and cooperativity reflect evolutionary and physiological ada

257 TGF-beta1-p53 cooperativity regulates a profibrotic genomic program in

258 ate modulation of binding affinity, and thus cooperativity, renders our new cuboctahedral receptor at

259 in contrast to the apparent strong negative cooperativity reported previously.

260 and acting in orthogonal directions: chelate cooperativity, responsible for the formation of robust W

261 MP with ~9-fold entropically driven positive cooperativity (rho(ITC) = 9 +/- 1, rho(NMR) = 7 +/- 1),

262 We show that (1) the cooperativity rules governing the induction of synaptic

263 e characteristic value k(a)(*), beyond which cooperativity saturates instead of decaying.

264 In the nonlinear regime, mechanical cooperativity sets in via a redundancy in the assignment

265 hree molecules of FimH, albeit with negative cooperativity, so that a molar excess of accessible N-gl

266 good model for studying enzyme kinetics and cooperativity, specifically for being able to separate t

267 gnate ATP/GTP substrate pair, while negative-cooperativity suppresses Mn2+ utilization by either ATP

268 mutant inhibition curves also showed greater cooperativity than the wild-type strain.

269 ts mononuclear counterpart due to bimetallic cooperativity that allows for the facile activation of s

270 mode always shows extremely high "unlimited" cooperativity that requires the IDL.

271 ng versus ATP concentration exhibited strong cooperativity that was further enhanced in the A666G mut

272 y specific protein-protein interactions, but cooperativity through DNA structure is becoming increasi

273 Here, we exploited antibody cooperativity to develop a therapeutic mAb cocktail agai

274 ails underlying the reported positive kinase cooperativity to enrich the discussion on how autonomous

275 rk2 loss and Pten loss also display striking cooperativity to promote tumorigenesis in vivo.

276 networks and cooperativity, linked positive cooperativity to structural proximity, and revealed ubiq

277 This homotetrameric enzyme exhibits strong cooperativity toward glycine binding.

278 ar interactions, meaning that information on cooperativity typically is derived from theory or indire

279 We found that mammalian Hb cooperativity values all reside on a ridge of maximum co

280 , estimates of ligand affinity, efficacy, or cooperativity varied depending on the assignment of the

281 Ca(2+)-binding cooperativity was examined assuming two different stoich

282 re placed in the same subunit, the resulting cooperativity was neutral.

283 By contrast, Ca(2+) cooperativity was unaffected.

284 n estimates of ligand affinity, efficacy, or cooperativity were observed when the slope was assigned

285 F dimers is limited by induction of negative cooperativity when bound to one site in the dimer(1-3).

286 her of its individual C2 domains, indicating cooperativity, whereas the major population of Syt-7 C2A

287 s: one CNB domain initiates cAMP binding and cooperativity, whereas the other triggers inter-domain i

288 biochemical assays in vitro suggest negative cooperativity, whereby phosphorylation in one protomer o

289 ex are determined by the degree of molecular cooperativity, which is enhanced for molecules with a po

290 portant for functional affinity and negative cooperativity, while functionalization of the thienopyri

291 ional affinity, as well as enhanced negative cooperativity with dopamine affinity and efficacy.

292 compounds were examined for their synergism/cooperativity with five clinical drugs against seven fun

293 illuminate structural principles of antibody cooperativity with implications for development of antiv

294 intains low muM affinity and robust negative cooperativity with markedly improved ligand efficiency.

295 Here, we investigated C2A-C2B interdomain cooperativity with Syt-1 and Syt-7 using directly compar

296 ding affinity as well as a source of binding cooperativity, with important implications for a predict

297 f larvae, therefore increasing the degree of cooperativity within a cluster.

298 We demonstrate the importance of AuxRE cooperativity within repeats in the Arabidopsis TMO5 and

299 c species, analogous to outer-sphere residue cooperativity within the active sites of enzymes.

300 miRNA, was highly upregulated in cancer, and cooperativity within this multicomponent locus promoted