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1 tion of replication from the upstream genome copy.
2 cation, the genetic information of a cell is copied.
3 enance of multiple mitochondrial DNA (mtDNA) copies.
4 -gene families for which Ash1 contains other copies.
5 y functional expressed elements and degraded copies.
7 were observed in 0-copy and A71915-treated 2-copy and 4-copy mice, but minimally occurred in Rp-treat
8 ip1) occurred in 0-copy and A71915-treated 2-copy and 4-copy mice, while Rp treatment caused minimal
9 , and tubular hypertrophy were observed in 0-copy and A71915-treated 2-copy and 4-copy mice, but mini
10 p38, p21(Cip1) , and p27(Kip1) occurred in 0-copy and A71915-treated 2-copy and 4-copy mice, while Rp
12 ven when viral load exceeded 1 x 107 HSV DNA copies, and surges in granzyme B and IFN-gamma occurred
17 ns from the average coverage in the sequence copy distribution can either cause wasteful provisioning
19 ies of the scaffolding protein Vac14 and one copy each of the lipid kinase PIKfyve, generating PI(3,5
21 y regulator HMGN1, a target of recurrent DNA copy gains in leukemia, controls myeloid differentiation
23 intron, and it has been shown to efficiently copy highly structured long RNA molecules in a single pa
31 ed in 0-copy and A71915-treated 2-copy and 4-copy mice, but minimally occurred in Rp-treated mice com
32 ed in 0-copy and A71915-treated 2-copy and 4-copy mice, while Rp treatment caused minimal changes tha
33 (TCID(50))/ml using inactivated virus and 25 copies/ml (c/ml) using synthetic in vitro transcript RNA
35 verall engaged-in-care HCV CVL was 4 351 079 copies/mL (standard deviation = 7 149 888); local HCV CV
36 gression models for time to viral load >1000 copies/mL (treatment failure), and simulated data for 10
41 + FTC arm had an HIV-1 RNA viral load of <50 copies/ml compared to 86/94 (91.5%) participants on stan
43 Limits of detection ranged from <=10 to 74 copies/ml for commercial high-throughput laboratory anal
44 , and Hologic Panther Fusion) and 167 to 511 copies/ml for sample-to-answer (DiaSorin Simplexa, GenMa
45 ths, and controlled plasma viremia at <10(4) copies/ml for up to 8 months after ATI and <200 copies/m
50 -treatment analysis, suppression below 1,000 copies/mL was 89.0% at month 12 and 90.4% at month 72.
51 asymptomatic subset, having viremia >=10 000 copies/mL was associated with a lower creatinine/cystati
52 Restricting to PLHIV, viral load of >=1000 copies/mL was associated with higher TNF-alpha levels (P
55 pressible viremia (plasma HIV-1 RNA above 40 copies/mL) despite reported adherence to ART and the abs
58 iretroviral therapy (last HIV viral load <50 copies/mL) is able to improve survival of coinfected pat
59 ion of patients with viral suppression (<100 copies/ml) through 48 weeks was 93.5% in the DTG + FTC a
60 gandan adults with virologic failure (>=1000 copies/mL) using leftover plasma after viral load testin
61 The risk of an elevated viral load (>=400 copies/mL) was independently lower among participants wi
64 >=90%) and virally suppressed (HIV RNA <200 copies/mL), before and after model implementation, were
65 st limit of detection (100% detection at 100 copies/ml), followed by ePlex (100% detection at 1,000 c
67 ean CD4 % was 34%, 93% had a viral load <=20 copies/mL, and 79% were on a nonnucleoside reverse trans
68 al load at baseline was 7.90 (SD 1.82) Log10 copies/mL, and median time from symptom onset to randomi
74 disease (plasma viral load [pVL] >50,000 RNA copies/ml; CD4 counts 283 cells/mm(3), n = 47) and relat
78 important allele-specific mutations-such as copy-neutral loss of heterozygosity (LOH) in cancer-are
79 omy 12, loss of chromosomes 13q and 13q, and copy-neutral loss of heterozygosity) were between two an
80 lowed us to retrieve the plastome, 57 single copy nuclear genes, and the nuclear ribosomal ITS from 2
84 nd MYD88(L265P) mutation and the genome-wide copy number aberration (CNA) profiles of individual vitr
89 ected pituitary adenomas showed that somatic copy number alteration (SCNA) rather than mutation is a
90 ng, we comprehensively map out the facets of copy number alteration heterogeneity in a cohort of brea
92 fluencing folate pathway genes (mRNA, miRNA, copy number alterations [CNAs], SNPs, single nucleotide
93 quency of whole chromosome or chromosome arm copy number alterations and were associated with an incr
94 r mutation burden, frequency of mutations or copy number alterations, mutation signatures, intratumor
95 tory checkpoints, genome-wide frequencies of copy number alterations, mutational signatures in whole
96 f the built environment with leukocyte mtDNA copy number among 5,502 Mexican American adults enrolled
97 n more than 40% of cancer cells and that MYC copy number amplification correlates with enhanced trans
100 suggest that parasites with increased pvdbp copy number are able to infect individuals with naturall
101 ns in mitochondrial DNA (mtDNA) sequence and copy number are implicated in aging and organ dysfunctio
102 ful segregation, or "partition," of many low-copy number bacterial plasmids is driven by plasmid-enco
104 ing 3 to 20 copies of NPNA revealed that low copy number can reduce the abundance of low-affinity mon
105 the circadian genes' omics profile, such as copy number changes and RNA-sequence data along with the
106 interface, investigators can easily observe copy number changes, mutations, and structural events in
108 pular model for copy number evolution is the copy number distance (CND), defined as the length of a s
110 it challenging to accurately detect abnormal copy number events in a cost-effective manner in clinica
113 data are consistent with a model in which 3B copy number expansion within the FMDV genome has allowed
116 udy population was stratified into low mtDNA copy number group (< median) and high mtDNA copy number
117 by an accordion mechanism in which the gene copy number increases followed by base substitutions and
119 V using the segmentation function to measure copy number inflection points throughout the genome.
120 uantification of nucleic acid targets at low copy number is problematic with the limit of detection a
124 and in female subjects de novo heterozygous copy number loss or truncating mutations cause haploinsu
125 tected by cytogenetics, and their associated copy number neutral loss of heterozygosity (CN-LOH) were
129 und negative dose-response associations with copy number on intracranial volume and on regional cauda
130 -type (WT) gene, due to either variations in copy number or transcriptional regulation, have also bee
131 CONCUR is built on the proposed concepts of "copy number profile curves" to describe the CNV profile
137 allele frequency patterns, to infer the true copy number status of genes and genomic regions from who
138 NA replication results in an increase in DNA copy number that can be measured by high-throughput sequ
139 of mitochondrial activity and altered mtDNA copy number that result in organ dysfunction in aging an
140 shed common variant, rare coding variant and copy number variant data, we examined the relationship b
151 egmental duplications overlap with recurrent copy number variants associated with neurocognitive diso
152 participants carrying at least one of the 12 copy number variants associated with schizophrenia in UK
159 t assessed by next-generation sequencing and copy number variation analysis, 3 molecular subtypes wit
160 scribe a computational method HiNT (Hi-C for copy Number variation and Translocation detection), whic
162 of this study is to evaluate expression and copy number variation of the ADAR gene in advanced GC an
164 urodevelopmental disorders caused by genomic copy number variations (CNVs) and gene expression data f
165 functional effects of somatic mutations and copy number variations (CNVs) not evident in transcripto
168 karyotyping analysis, none of the predicted copy number variations (CNVs) were identified, which con
169 cleotide variations (SNVs) to large, complex copy number variations (CNVs), have been reported in pat
170 and Translocation detection), which detects copy number variations and interchromosomal translocatio
171 ngs demonstrate a mechanism by which smaller copy number variations, not including the Pmp22 gene, ar
173 exposures, we measured cell viability, mtDNA copy number, and mitochondrial bioenergetics utilizing t
176 l lines for TERT promoter mutational status, copy number, gene expression, and telomere length to pro
177 n does not, however, correlate with FeLV env copy number, suggesting that this effect is specific to
179 espite a significant increase in bla(TEM-1B) copy number, the TZP-resistant isolate does not incur a
180 levels of oncogene transcription compared to copy number-matched linear DNA, coupled with enhanced ch
185 replication stress and an abundance of focal copy-number alterations associated with activation of th
186 genes and pathways preferentially mutated or copy-number altered in metastases compared with the pair
187 ing a novel integrative analysis of absolute copy-number analysis and gene expression in The Cancer G
188 eveal the average replication dynamics using copy-number analysis in any proliferating asynchronous c
189 MGMT promoter methylation were determined by copy-number arrays and/or Illumina 450K array, respectiv
192 varied chromosomal structures with low-level copy-number gains and frequent inverted rearrangements.
194 is profiles display oscillations between two copy-number states, a considerable fraction of events in
195 s), small insertions and deletions (indels), copy-number variations (CNVs), loss of heterozygosity (L
196 pression data, with optional corrections for copy-number variations and able to run on signatures gen
198 s was accompanied by lower mitochondrial DNA copy numbers (p < 0.001), mtND1 expression (p < 0.001) a
199 d conserved in canonical sequence motifs and copy numbers as in E. maclovinus, showing limited impact
201 exing dPCR assay for measuring SMN1 and SMN2 copy numbers in spinal muscular atrophy (SMA) samples ha
202 DNA image cytometry profiles, enumeration of copy numbers of eight breast cancer genes by multicolor
209 s is a powerful nanomachine built by several copies of a large (TerL) and a small (TerS) terminase su
211 id tetraploid maize lines that contain three copies of chromosome 10 derived from inbred lines B73 an
212 ial requirement for inactivation of multiple copies of disease-associated RNA and therapeutic efficac
213 multivalent RNA nanoparticle harboring three copies of hepatocyte targeting-ligands, one copy of miR1
216 her fundamental question: Starting from many copies of noisy quantum clocks which are (approximately)
217 aring antigenicity of TMV displaying 3 to 20 copies of NPNA revealed that low copy number can reduce
218 argeting-ligands, one copy of miR122, and 24 copies of Paclitaxel to overcome the drug effluxion and
219 or subclones with mutations to the remaining copies of PTEN and TP53, while the Gleason 7 PTEN-intact
222 es in inclusion bodies comprised of numerous copies of the 150-kDa ATI protein, which can provide sta
224 angulation number T = 277) composed of 8,280 copies of the double jelly-roll major capsid protein (MC
225 Hence, RDV residues could be embedded in copies of the first RNA strand that is later used as a t
226 We find the PIKfyve complex comprises five copies of the scaffolding protein Vac14 and one copy eac
228 to other eukaryotes, plants harbor multiple copies of these JDPs, which posit that plants have an in
229 It is robust, can consistently detect two copies of viral RNA, with a limit of detection of a sing
233 able to identify the parental origin of each copy of chromosome 10 in the materials using oligonucleo
234 t the expression of the paternally inherited copy of Dot1l in the embryo is sufficient to support dev
235 each binding site in CPSF30 still allows one copy of hFip1 to bind, while mutation of both sites abro
236 copies of hepatocyte targeting-ligands, one copy of miR122, and 24 copies of Paclitaxel to overcome
237 other four containing at least one wild-type copy of Ppal15kDa was compromised at varying levels.
238 determine whether activation of the maternal copy of SNORD116 could be achieved without altering ZNF2
242 Approximately 1% of people worldwide carry a copy of the human herpesvirus 6A or 6B (HHV-6A/B) in eve
244 We find that efferents transmit a precise copy of the motor signal and a single spike in the motor
247 e event GR2E confirmed insertion of a single copy of the transfer-DNA in the genome and its inheritan
248 ceptor, but stably introducing an additional copy of this receptor did not further enhance susceptibi
252 with the risk allele (17-58% increase/allele copy, P = 0.046-0.002), including five gamma-glutamyl am
253 ve traces and sensing electrodes, and office-copy papers work as flexible supporting substrates.
254 as positive for the long-terminal repeat (33 copies per 10(6) cells) and env (26.1 copies per 10(6) c
255 at (33 copies per 10(6) cells) and env (26.1 copies per 10(6) cells), negative for psi and integrase,
257 , a virologic response (HIV-1 RNA level, <40 copies per milliliter) had occurred in 54% of the patien
259 days after dose decreased from 1.67 log(10) copies per mL (95% CI 1.42-1.92) at 10 mg dose to 1.20 l
260 imary endpoint at week 48 was HIV-1 RNA >=50 copies per mL (Snapshot, intention-to-treat exposed), wi
261 asma HIV-1 RNA concentration of less than 50 copies per mL at week 48, which has been reported previo
262 delivery who had viral load of at least 200 copies per mL before treatment and no genotypic resistan
265 outcome was combined viral suppression (<200 copies per mL) and retention at 12 months after enrolmen
266 ention in care with viral suppression (<1000 copies per mL) at 6 months using logistic regression.
267 to be in care, viral load suppression (<200 copies per mL) was based on the last viral load in the y
270 site poor outcome (defined as viral load >50 copies per mL, or for participants with a missing viral
273 rior to dosing every 4 weeks (HIV-1 RNA >=50 copies per mL; 2% vs 1%) with an adjusted treatment diff
274 uppressed viral load [NVL; viral load >=1000 copies per mL], and loss to follow-up [LTFU; >180 days l
275 iral load suppression [VLS; viral load <1000 copies per mL], retention in care with non-suppressed vi
277 group had an HIV viral load of at least 1000 copies per muL or had died (adjusted prevalence ratio 0.
281 howing high sensitivity (down to 100 genomic copies/reaction) and high specificity (no cross-reactivi
283 rete clusters containing approximately eight copies regardless of cell size and that the total number
285 ipartite structure containing a large single copy region of 82,084 bp and small single copy region of
286 in the reference sequence revealed many low-copy repeats, most of which overlap predicted coding seq
287 ion limit on patient samples down to 5 viral copies, requires minimal instrumentation, and is highly
288 ution chromosome-conformation-capture carbon-copy sequencing (5C-seq) to elucidate the extent to whic
289 e large number of endogenous RD histone gene copies sequester available factor(s) from attenuated tra
290 ing a duplicate retention model in which one copy tends to have more sub-functions than its paralog.
291 s social feedback rules, whereby individuals copy the decisions they observe others making, creating
293 tandem minus-strand complementary DNA genome copy under the control of a cytomegalovirus (CMV) promot
294 archival system to study the oligonucleotide copy unevenness problem and show that the two paramount
296 0, so that only about one out of 900,000 RNA copies was of human origin, but the RNA quality (average
298 Strain P3.1 exhibited the loss of one IS256 copy, which was originally located in the HU-14 noncodin
300 dorferi) recA gene with a sensitivity of 100 copies within 25 min and generated stronger specific flu