ライフサイエンスコーパス: core

1 molecule compatibility with 3HM's alkyl tail core.

2 ed proteins, together constituting the viral core.

3 cage-opened dianionic nido-C(2)B(10) cluster core.

4 e binding sites for the LHCIs around the PSI core.

5 substituted, nitrogen-containing heterocycle core.

6 e, lipid interface and the lipid hydrophobic core.

7 protonated Glu8 is located in the fibrillar core.

8 ith a dihydropyrrolo[1,2-a]pyrazin-3(4H)-one core.

9 fiber clearly indicate guidance in the fiber core.

10 resent the structure of the DHp-CA catalytic core.

11 w tetrameric channel with a strongly charged core.

12 to conformational changes of their catalytic core.

13 produces acylsugars containing a myoinositol core.

14 nsient synaptic enlargement in the accumbens core.

15 nonfilling porous structure, and a graphite core.

16 d electronic superatom spectrum of the inner core.

17 hydrophobic moieties into the lipid bilayer core.

18 the rapid diversification of heteroaromatic cores.

19 ation of minimal autocatalytic motifs called cores.

20 g compounds and libraries sharing structural cores.

21 distribution of microplastics within sea ice cores.

22 about their interaction with the photosystem cores.

23 We first quantify the Core 1 and 2 O-glycan structures on the carbohydrate rec

24 substrate specificity and includes mammalian cores 1-8.

25 Here, we confirm that the core 2 O-linked glycans mediate this lubricin-galectin-3

26 that recombinant lubricin (rhPRG4) devoid of core 2 structures did not bind to recombinant galectin-3

27 ment of Cancer Quality-of-Life Questionnaire-Core 30 (QLQ-C30) and Lung Cancer 13 (QLQ-LC13) were adm

28 These structures reveal that the imidazole core acts as an H-bond acceptor for the catalytic lysine

29 Our results provide key constraints on inner core age that could be older than two billion-years.

30 A "core" airway resistome dominated by macrolide but with h

31 and DAD2(F135A), having substitutions in the core alpha/beta hydrolase-fold domain and the hairpin, e

32 he conformation of RNA duplexes bound to the core also shows bending.

33 This approach assigns to each core an equal number of biochemical reactions without co

34 tion (DESI)-MSI defined regions of a hypoxic core and a proliferative outer layer from metabolite dis

35 n aggregates comprising a cross-beta amyloid core and are associated with deadly human diseases.

36 the integrative memory model supporting the core and attribution functions.

37 n D1+ neurons in the nucleus accumbens (NAc) core and dorsolateral (DLS) striatum in Npas2 mutant fem

38 We find that variations in the common core and emergence of hypervariable loops extending from

39 -layer structure contains a magnesium engine core and inner chemoattractant and therapeutic layers.

40 side chains of the Nte residues and the FimA core and not by the antiparallel orientation of the dono

41 ineering fusion proteins consisting of gp120 Core and one or two CD4-induced (CD4i) mAbs for masking

42 nto states at the interface of the inorganic core and organic ligand shell by so-called "exciton-delo

43 repared by loading ascorbic acid (AA) in the core and poly(lactic-co-glycolic acid) shell incorporati

44 identified and resolved in both the filament core and reservoir regions.

45 Fibers with ferrite cores and PZT shells were prepared by electrospinning.

46 ages from a well-dated ice core to a nearby core, and by tracing isochronous layers within the ice s

47 tructure and materials comprising their main core, and, in perspective can be considered for function

48 by individually exciting the single-mode MCF cores, and that these patterns are highly stable to fibr

49 trition Examination Survey who completed HBV core antibody (anti-HBc) and surface antigen (HBsAg) tes

50 We estimated the prevalence of total HBV core antibody (anti-HBc) positivity, indicating a previo

51 twice with a mixture of adjuvanted HBV S and core antigen, followed by a modified Vaccinia virus Anka

52 s low did not have detectable HCV viral load/core antigen.

53 hat amino acids buried within the structural core are network-central, and those on the surface are n

54 ctural modifications at the central aromatic core are presented.

55 Two of these cores are related to the spectral properties and walks o

56 Am), held above its LCST, formed hydrophobic cores around which shells composed of NIPAm, degradable

57 d that reactivity to classical CCD epitopes (core beta-1,2-xylose, alpha-1,3-fucose) was positively a

58 which facilitates insertion of the catalytic core between the histone octamer and the unwrapped segme

59 Newer formulations with carbohydrate cores binding elemental iron more tightly allow complete

60 ns containing polyglutamine tracts including core-binding factor alpha1, mediator subunit 12, transcr

61 (ROC) analyses and compared with that of CSF core biomarkers Abeta42, P-tau and T-tau.

62 ed reduced expression of genes that regulate core biosynthetic processes.

63 Order effects, core body temperature changes due to menstruation, and c

64 fects are partly mediated by the lowering of core body temperature that occurs during CR.

65 ses in cerebral blood flow (CBF), as well as core body temperature; however, the isolated influence o

66 Lipid core burden index (LCBI) was calculated as the fraction

67 and amortization (EBITDA; pretax profit from core business activities); and net income, also referred

68 chromatin remodeling complex, including its core catalytic subunit, SMARCA4.

69 ic alterations are initiated by HDAC1 in GBM core cells which subsequently affect edge cells by secre

70 LAM(CORE) cells expressing signature genes included known LA

71 ells.Conclusions: A unique population of LAM(CORE) cells was identified in lung and uterus of patient

72 ore, cognitive abnormalities are established core characteristics of schizophrenia.

73 ding components of the negative limbs of the core circadian clock, most notably REV-ERBalpha.

74 efforts to improve the measurement of these core clinical outcomes.

75 tion, acting in part through the NPC, alters core clock gene expression and/or mRNA accumulation in a

76 s of day resulted in differential changes of core clock gene expression, demonstrating an exercise an

77 adian clock phase, likely through changes in core clock gene expression.

78 D induced steatohepatitis barely affects the core clock mechanism but leads to a reprogramming of cir

79 Mutation of the core clock protein REVERBalpha in these cells exacerbate

80 The identified core collection accessions rich in specific and multiple

81 A core collection developed previously with smaller number

82 imate of Louisiana warrant a region-specific core collection that can be used for base-broadening bre

83 e invited to respond to a 39-item survey (18 core competencies; 9 noncore or emerging topic-related c

84 ue Ni(2)(OR)(2) (OR = alkoxide) diamond-like core complemented by a mu-iodo bridge between the two Ni

85 ole of amylin signaling in POMC neurons, the core component of the amylin receptor, calcitonin recept

86 Here, we show that a core component of the fork protection complex in the euk

87 BMAL1 is a core component of the mammalian circadian clockwork.

88 Biologic agents have become a core component of therapeutic strategies for many inflam

89 obustly immunoprecipitated in vivo with PRC2 core components and the accessory proteins, EMBRYONIC FL

90 betaPS integrin and sarcoglycan delta, both core components of costameres, are elevated in TRIM32 di

91 This study has shown that adopting defined core components of ESD is associated with providing a mo

92 l biodegradable nanoparticle (NP) entries as core components of nanoscale drug delivery systems (NDDS

93 found that the LATS1 and LATS2 kinases, the core components of the Hippo pathway, phosphorylate S606

94 vealed specific alterations in Hippo pathway core components, as a function of DDR and collagen expre

95 he uniporter complex (uniplex) contains four core components: the pore-forming MCU protein, the gatek

96 uld be routinely reported in addition to the core CONSORT 2010 items.

97 ce of hypervariable loops extending from the core contributed to GT-A diversity.

98 Here, we analyze the requirements for core CPC subunits, survivin and INCENP, and the mitotic

99 multidisciplinary experts in the field, new core criteria based on contemporary cardiovascular imagi

100 A common core dataset is proposed, to achieve harmonization of re

101 Here we study the [Formula: see text]-core decomposition of some empirical networks as well as

102 Among the 20 CORE-derived recommendations, 19 (95%) were concordant w

103 Therefore, adopting CT to complement visual core description in the ichnological analysis of soft mo

104 ufactured with or without a degradable inner core designed to modulate aqueous humor outflow to provi

105 e, and clinical psychology to highlight four core dimensions of well-being-awareness, connection, ins

106 HIV-1 capsid core disassembly (uncoating) must occur before integrati

107 network-correcting therapies that treat the core disease mechanism.

108 The core disease signature revealed remarkably strong connec

109 itional substitution in the triazolopyridine core disturbed the binding to phosphatidylinositol 4-kin

110 B, CSA and UVSSA and the manner in which the core DNA repair complex, including transcription factor

111 hat nidoviruses contain a conserved helicase core domain and key amino acid sites affecting helicase

112 The NTD-core domain of Aedes aegypti Nbr adopts a HEAT-like repe

113 A useful simplification can elucidate the core dynamics of a system.

114 MHV68 infection should provide insight into core elements of SINE regulation, as well as disregulati

115 In addition, structural analysis identifies core elements that define the CARF domain fold, and the

116 Here, we show that 4 bp of core-enclosing helix is required for telomerase to be ac

117 Consequently, some pathogens have evolved 'core environmental responses' which exploit host signals

118 e promoter recognition sigma factor from the core enzyme.

119 n sequencing has been employed to define the core essential genome of this bacterium and genes condit

120 Gender identity is a core feature of human experience, yet our understanding

121 e mode coupling effect of a seven core multi-core fibre, we have achieved a sensitivity of - 1.4 nm/

122 on of [Co(L1)](2+) into the liposome aqueous core, followed by dialysis against a solution of 300 mOs

123 work will spur interest in using macrocyclic cores for in silico-based lead generation and also inspi

124 r (NER) in eukaryotes is orchestrated by the core form of the general transcription factor TFIIH, con

125 Stereospecific polycyclic core formation of hapalindoles and fischerindoles is con

126 Based on a multistage model of core formation, the core likely contains a maximum of 0.

127 This signature enables precise mapping of core fragility regions in known CFSs and identification

128 based on a tricyclic dihydrochromenopyrazole core from which emerged nidufexor (LMB763), a compound w

129 The importance of core fucosylation can be seen in the complex pathologica

130 m a soil microbiology study demonstrates the core functionality of the package and highlights the cap

131 pid compositions, specifically the degree of core GDGT cyclization.

132 e built from small sets of randomly-selected core genes after removing the AMR genes.

133 aeruginosa genomes to curate a set of 4,440 core genes found in each isolate, representing ~64% of t

134 which might be involved in the regulation of core genes of AF and NP transcriptome.

135 resolved gonococci into discrete and stable core genome groups, some of which persisted for multiple

136 MLST-STs were more widely distributed among core genome groups.

137 Here we introduce a generalized GREML, named CORE GREML, that explicitly estimates the covariance bet

138 Evolutionary conservation of the core Hh signaling pathway, as well as conservation of ep

139 ized into chromatin through association with core histone proteins to form nucleosomes.

140 the post-translational citrullination of the core histones H3 and H4.

141 ate concentrations recorded in Antarctic ice cores imply that the cooling would have been more pronou

142 thiafulvalene (TTF) with a nickel glyoximate core in a family of isostructural conductive MOFs with M

143 but the spin density is distributed over the core in a nonuniform fashion.

144 BODIPY-cyclopamine on the SMO transmembrane core in live cells in real time.

145 ly balances the computation load between the cores in runtime which guarantees equal convergence time

146 mulated with a PBD-lipid containing a BODIPY core, indole linker, and PEG length between 1000 and 500

147 ted which revealed that the face-to-face pai-core interaction induced by benzo[2,1,3]thiadiazole S-N-

148 While the core interactions between SUN and the C-terminal residue

149 ain fatty acid (VLCFA) synthesis pathway and core interactor.

150 The core is composed of lambda1 decamers held in place by si

151 as a result of septic shock, and its lipid A core is the target of polymyxin antibiotics(3,4).

152 ichnological analysis of soft modern marine cores is a very informative approach.

153 Our findings indicate that the diamond core isomerization is likely a practical enzymatic strat

154 vate the pathway, but how each controls this core kinase cassette is not fully understood.

155 Scans were interpreted in a core laboratory by 2 imaging experts, using the visual D

156 striatum (medial accumbens shell, accumbens core, lateral accumbens shell) and showed complex and he

157 a inhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavai

158 approaches, we identified a novel quinoline core ligand, BMPQ-1, which bound to human telomeric G-qu

159 on a multistage model of core formation, the core likely contains a maximum of 0.09(4) to 0.20(10) wt

160 responses in growth rate, biomass yield, and core lipid compositions, specifically the degree of core

161 These data sets reveal dynamic changes of core liver functions and canonical signaling pathways go

162 nd compared to U distributions in three soil cores located in a wetland highly impacted by water disc

163 oof-of-concept scheme consists of a spinning core made of uncured polydimethylsiloxane (PDMS) and fix

164 cture has historically been seen as having a core-mantle arrangement.

165 Fibronectin (FN) is a core matrix protein that assembles to form a dynamic cel

166 tep reaction and, with the help of Cdt1, the core Mcm2-7 helicase onto DNA.

167 Long-term damage was found in the ablated core (mean fractional anisotropy [FA] at baseline, 0.41

168 d synthetic communities constructed from the core members of the fruit fly gut microbiota.

169 is organism during infection are centered on core metabolism and virulence factor synthesis.

170 ate the submitochondrial localization of the core MICOS subunit Mic60 in relation to two other MICOS

171 epresented minorities, to the success of the core missions of the Society.

172 anosized fuel, and spherical lubricating oil core mode particles contained, e.g., calcium as well as

173 res(10-14), but the structure of the central core module is unknown.

174 is clockwise/counterclockwise chiral cap and core molecules.

175 monstrate that FDL1 directly binds to CCAACC core motifs present in AD1 regulatory regions to activat

176 bility and cis-regulatory elements uncover a core mRNA-ncRNA transcriptional signature shared by IgG(

177 timising the mode coupling effect of a seven core multi-core fibre, we have achieved a sensitivity of

178 samples, indicating that they are part of a core mycobiome, though crop management influenced richne

179 sy of 43% (181 true-positive findings of 419 core-needle biopsies).

180 ay requires the interaction of NBAS with the core NMD factor UPF1, which is partially localized at th

181 C1d, and implicated aIPg and pC1d neurons as core nodes regulating female aggression.

182 The core nucleosome performs a fundamental regulatory role,

183 alized layer of the visual DVR that form the core of a dense network of highly specific connections b

184 ibitors based on the atomic structure of the core of alpha-syn fibrils.

185 to kinetochore proximal centromeres and the core of chromosome arms.

186 t changes in glutamate homeostasis in the NA core of cocaine + alcohol rats relative to rats consumin

187 ity gradient, a fundamental parameter at the core of Density Functional Theory.

188 A core of fibrinogen and monocytes was found in 39 (93%) w

189 At the core of marcAST is a ready-to-use microwell array device

190 Entrusting autonomy is at the core of teaching and learning surgical procedures.

191 tite-rich subsurface layers in the hyperarid core of the Atacama, and the collection of biosignatures

192 Here we examine the doubly reduced FeMo-co core of the E(4)(2H)* limiting-state by (1)H, (57)Fe, an

193 nonical nature of the transformations at the core of the events that define the morphological shape f

194 At the core of the glideosome is an essential and divergent Myo

195 that phenols were located in the hydrophobic core of the micelle.

196 dure was illustrated by synthesizing partial core oligosaccharide structure present in the lipopolysa

197 unctionalization of imidazo[1,2-a]pyrimidine cores on the C6-position.

198 express mutually exclusive markers, exhibit core or shell-like anatomical structure and have distinc

199 -delirium-specific outcome domains within 19 Core Outcome Measures in Effectiveness Trials taxonomy c

200 The PICU core outcome set and PICU core outcome set-extended are

201 vidence-informed and stakeholder-recommended core outcome set is lacking for pediatric critical care

202 The PICU core outcome set and PICU core outcome set-extended are multistakeholder-recommend

203 portant" and were included in the final PICU core outcome set: four Global Domains (Cognitive, Emotio

204 oducing CNS innate immune cells identified a core oxidative stress gene signature coupled to coagulat

205 ion in which P2 primarily lies closer to the core/P1 domains than suggested in the SurA crystal struc

206 e lineages by shuffling the genes encoding a core palette of triterpene-diversifying enzymes, presuma

207 Homo sapiens CHD4 engaged with a nucleosome core particle in the presence of the non-hydrolysable AT

208 The core pathology of coronavirus disease 2019 (COVID-19) is

209 helical scaffold by a secondary hydrophobic core, pinning down the long loops of leptin to the prote

210 esicular recycling endosome membranes were a core platform on which the critical early events of auto

211 We tested core predictions of the food limitation hypothesis using

212 This Review discusses the core priority treatments for OA, including exercise and

213 If the CORE process had been used, 11 systematic reviews would

214 Recommendations derived from the CORE process were compared to the guideline recommendati

215 Inhibition of VTA-core-projecting neurons disrupted Pavlovian reward learn

216 tivation of thalamo-accumbens shell, but not core, projectors attenuated heroin seeking in FDR rats.

217 how that the DPR is a functionally important core promoter element that is widely used in human promo

218 vage assay we found that the wild type hTERT core promoter folds into a stacked, three-parallel G-qua

219 apturing enhancer function, and confirm that core promoter sequences are necessary for this activity.

220 DNA consensus motifs of early and late ASFV core promoters, as well as a polythymidylate sequence de

221 Retromer recognition core proteins were significantly decreased in DS fibrobl

222 f the T4aPM and the location of 10 conserved core proteins within this architecture have been elucida

223 nhibition of the function of individual PRC2 core proteins, the disruption of PRC2 complex formation,

224 f the cyclopentenyl ring to the plane of the core quinoline to be a crucial determinate of PAM activi

225 but parameters related to identification of core reactions, such as thresholding of expression profi

226 identification of a list of high confidence (core) reactions from transcriptomics, but parameters rel

227 dicators to identify seismic faults in drill core recovered from the Japan Trench subduction zone, wh

228 e localized regulatory activity to a central core region that depends on the motif sequences of our p

229 nal ribose and ManNAc instead of ManN in the core region, suggesting that these differences may contr

230 structurally and functionally connected with core regions of the SMN, whereas the ventral tegmental a

231 (VTA)-related mesocorticolimbic pathway with core regions of the SN.

232 single-cell RNA-seq data, we showed that the core regulatory modules can reflect the properties of di

233 hepatitis B virus (HBV) RNA and hepatitis B core-related antigen (HBcrAg) as surrogates of silencing

234 The net result is that cisternal cores remain stacked, but cisternal diameter is reduced

235 Combining two core research approaches (household survey analysis, pro

236 The L protein is organized as a core ring-like domain containing the RNA-dependent RNA p

237 aking carbon a negligible contributor to the core's composition and density.

238 re re-entered for study measurements, a bone core sample, and implant placement.

239 ble strategy, which avoids alteration of the core sequence of the microprotein.

240 estingly, the functional annotations of this core set center around response to energy crisis and ren

241 olitional behavior paradigm, we identified a core set of brain endothelial genes whose expression is

242 A core set of priority constructs was proposed that allows

243 , organized as a T = 19 capsid, confines the core shell, and it is composed of the mature products de

244 A self-organized core-shell composite anode, comprising an outer sheath o

245 The data demonstrated that this core-shell hydrogel is an effective strategy for promoti

246 Using core-shell nanoparticles (NPs) as a building block, the

247 orms an extended interpenetrating network or core-shell-structured gel beads-a rare example of a supr

248 Forming Co(2)P/MP(x) core/shell NRs and subsequently converting them into CoM

249 ields a molecular model of the transmembrane core signalling unit and enables spatial localisation of

250 o elucidate signalling mechanisms within the core signalling unit and larger array.

251 om ice-penetrating radar between the two ice core sites.

252 hly degenerate mammalian splice sites by the core spliceosomal machinery is regulated by several prot

253 rates how metazoan-specific additions to the core STING scaffold enabled a switch from direct effecto

254 isturbance of metacommunity hub species with core structural and functional roles for their use in re

255 We observe that INVS is the core structural determinant of a compartment composed of

256 niches; stromal cells produced predominantly core, structural ECM proteins and tumor cells produced a

257 ings indicate that the twin-His motif is the core structure responsible for substrate deprotonation a

258 Arylazopyrazole derivatives based on four core structures (4pzMe, 3pzH, 4pzH, and 4pzH-F2) and fun

259 a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to a

260 We performed an intensive coring study within a sub-tropical estuary to assess the

261 n of the hidden dynamics has been one of the core subjects in systems biology, and is the focus of th

262 Eukaryotic TSEN is comprised of four core subunits (TSEN54, TSEN2, TSEN34 and TSEN15).

263 essive complex 2 (PRC2) is composed of three core subunits, enhancer of zeste 2 (EZH2), embryonic ect

264 lexible and partly detached from the histone core, suggesting sequence-dependent dynamics of the DNA

265 12-positions of the hetero[5]helicene inner core surface.

266 nti-IgLON5 disease, sleep disorders were the core symptoms that led to the description of this diseas

267 the temporal lobe structures subserving the core system and that the right temporal structures mainl

268 Acute moderate-intensity exercise increases core temperature (T(c) ; +0.7-0.8 degrees C); however, s

269 Our core template-based method is an algorithmic approach th

270 fic gene-expression program; the ensemble of core TFs and their regulatory loops constitutes core tra

271 These core TFs form interconnected feed-forward transcriptiona

272 envelope (the region surrounding the stellar core that contains partially ionized and partially degen

273 sh regionally derived models of GBM edge and core that retain their spatial identity in a cell autono

274 ther by two stacked G:C pairs at the central core that rotate with respect to each other in an X-shap

275 At its core, the goal of graduate and postdoctoral training is

276 ubstrate and docking domains with the kinase core, thus preventing catalytic activity.

277 amples to map the ages from a well-dated ice core to a nearby core, and by tracing isochronous layers

278 tungsten carbide nanoparticles to the metal core to arrive at wire lengths more than 30 cm with diam

279 nteractions, while further extending the IDT core to promote interchain charge transfer, is a logical

280 tory subunits of these AHAS complexes form a core to which the catalytic subunit dimers are attached,

281 XUV transient absorption measuring iodine 4d core-to-valence transitions.

282 e TFs and their regulatory loops constitutes core transcriptional regulatory circuitry (CRC).

283 cell type composition, gene expression, and core transcriptional regulatory networks.

284 ogenicity of this variant in a member of the core TRAPP subunit, TRAPPC4 that associates with vesicul

285 Here, we assembled core U7 snRNP bound to FLASH from recombinant components

286 bit dopamine uptake in the nucleus accumbens core using fast scan cyclic voltammetry ex vivo.

287 in permeability in trophoblasts and stromal cores using a dextran-based fluorescence assay and chang

288 ermal cell layer transcriptome confirms that core UV-B stress signaling pathway genes are conserved a

289 the peak wavelength or intensity of the CdSe core UV-vis absorption and ORF, but it reduces the QD fl

290 ACNP leadership that embrace diversity as a core value and support collaboration among key committee

291 pigment dispersing factor (PDF) filled dense core vesicles (DCVs) to the terminals at the dorsal prot

292 scade that connects two preexisting aromatic cores via a formal C-H activation step.

293 Sediment cores were digested and separated using a high-density s

294 In this little-explored habitat, 250 soil cores were sampled from 10 plots hosting 10 different pl

295 f loops around a thin (<130 nm) MukBEF axial core, whose length is ~1,100 times shorter than the chro

296 chromosomal loci is maintained in the axial cores, whose formation requires MukBEF ATP hydrolysis.

297 s A-E (1-5) comprise an unreported tricyclic core with a [6,6]-spiroketal system.

298 sembly of homologous U(VI)(mu-O(Ar))(2)M(n+) cores with a range of mono-, di-, and trivalent Lewis ac

299 tly link multi-electron redox responsive POM cores with virtually any (bio)organic molecule or metal

300 lecules cofacially pack via their end groups/cores, with the shortest pai-pai distance as close as 3.