ライフサイエンスコーパス: core protein

1 with the C-terminal arginine-rich domains of core protein.

2 n experimental class of antivirals that bind core protein.

3 FRRS1L, which encodes an AMPA receptor outer-core protein.

4 tached to chondroitin sulfate on the bikunin core protein.

5 ing of the mu subunit of AP-2, AP2M1, to HCV core protein.

6 re of an antiviral compound bound to the HBV core protein.

7 ressed in cells replicating DHBV with the WT core protein.

8 ing cytoplasmic lipid droplets with NS5A and core protein.

9 unction, which is exerted likely via the BGN core protein.

10 ated sequence contiguous with the linkage to core protein.

11 in the alpha-helical structure of the TILRR core protein.

12 re enzymatically degraded or absent from the core protein.

13 731, an investigational inhibitor of the HBV core protein.

14 sis from A36V mutant than from the wild-type core protein.

15 n with the distinct quaternary structures of core protein.

16 an enrichment filter were utilized to define core proteins.

17 SII core complexes and co-immunoprecipitates core proteins.

18 on, and light vulnerability of photosystem I core proteins.

19 , while not changing expression of ribosomal core proteins.

20 sites possibly masked in the virus by other core proteins.

21 eaction by bridging the L7Ae and fibrillarin core proteins.

22 complexes are each assembled with three sRNP core proteins.

23 lustering and promotion of bridging by other core proteins.

24 nteract only with their cognate nucleocapsid core proteins.

25 the hexon, penton, fiber, minor capsid, and core proteins.

26 ncreased amounts of unprocessed membrane and core proteins.

27 rates of antibodies against the hepatitis B core protein (0.99% and 1.88%; P = .19) and HBsAg (0.14%

28 tochondrial ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) gene, which co-segregates with d

29 lex containing five assembly factors and two core proteins, 15.5K and Nop58; (b) the characterization

30 itive for antibodies against the hepatitis B core protein (16.76%) and HBsAg (9.26%) than children wi

31 s question by studying the hepatitis C virus core protein, a chaperone that promotes viral genome dim

32 ation on the EGF-like repeat of the versican core protein, a proposed substrate of Fringe beta-1,3-N-

33 large set of peptides derived from the major core protein A10L and other known vaccinia epitopes boun

34 ells infected with VACV expressing the viral core protein A4 fused to yellow fluorescent protein.

35 Yeast two-hybrid experiments identified PG core proteins ABC1K3, PES1, and CCD4 as PGM48 interactor

36 Several baculovirus conserved (core) proteins (Ac76, Ac78, GP41, Ac93, and Ac103) that

37 d differences were observed in 8 of their 18 core proteins after left ventricular assist devices impl

38 Core protein allosteric modulators (CpAMs) are an experi

39 , and such molecules are collectively termed core protein allosteric modulators (CpAMs).

40 Small molecules that target core protein (core protein allosteric modulators [CpAMs]) represent a

41 ith cell culture-grown HCV or expressing HCV core protein also displayed significant repression of C9

42 Ft-Ds-Fj-mediated cues are weak and that the core proteins amplify them.

43 e, we identify HSPGs containing a glypican 5 core protein and 2-O-sulfo-iduronic acid residues at the

44 aracterized protein that is a PSII auxiliary core protein and hence is named PHOTOSYSTEM II PROTEIN33

45 aracterized an interaction between the viral core protein and host protein within bgcn homolog (WIBG)

46 hains, syndecan-4 binding relies on both its core protein and its heparan sulfate chains.

47 rboxyl-terminal domain (CTD) of hepadnavirus core protein and its state of phosphorylation are critic

48 s (LDs) and facilitates its interaction with core protein and the viral assembly.

49 Adjuvant envelope or core protein and virus-vectored nonstructural antigen va

50 ith this, GPC6 interacts with Hh through its core protein and with Ptc1 through its glycosaminoglycan

51 nomes are normalized for diversity with 1867 core proteins and a paralog-collapsed pan-genome size of

52 omology to the conserved T4SS outer membrane core proteins and F-type-specific proteins and we confir

53 Loss-of-function mutations in glypican core proteins and in glycosaminoglycan-synthesizing enzy

54 h a specific proteome of approximately 30 PG core proteins and isoprenoid and neutral lipids.

55 ant inverse relationship between recognition core proteins and levels of soluble forms of Abeta 1-40

56 n invertebrates, however, knowledge of CSPGs core proteins and proteoglycan-related functions is rela

57 is necessary for the stabilization of snoRNP core proteins and target of rapamycin activity and likel

58 Although many of the genes that encode HSPG core proteins and the biosynthetic enzymes that generate

59 hesizing enzymes have revealed that glypican core proteins and their glycosaminoglycan chains are imp

60 o chromosomes, whereas Mip130 (Lin9) (an MMB core protein) and E2f2 (an MMB transcriptional repressor

61 To establish asymmetry, these core proteins are sorted from an initially uniform distr

62 roteins redistribute and colocalize with HCV core protein around lipid droplets (LDs).

63 gnized CpAM activity is that they accelerate core protein assembly and strengthen interactions betwee

64 HBV core protein assembly can be modulated by heteroaryldihy

65 It is anticipated that small molecular core protein assembly modulators may disrupt one or mult

66 structure of N-glycosylated human glypican-1 core protein at 2.5 A, the first crystal structure of a

67 ermore, hepsin directly cleaved the aggrecan core protein at a novel cleavage site within the intergl

68 ethods to determine the dynamics of eisosome core proteins at different subcellular locations.

69 The expression of several HS core proteins, biosynthesis, and modification enzymes wa

70 We further observed the core protein BMAL1 and PER2 in DRG neurons and satellite

71 apsids through specific interaction with HBV core protein but not other viral and host cellular compo

72 MRB1 consists of six core proteins but makes dynamic interactions with additi

73 uced a protocol to characterize proteoglycan core proteins by identifying CS-glycopeptides with a com

74 four times more alternative nucleotides than core protein-coding regions that diversify exclusively v

75 osections revealed that the HCV envelope and core proteins colocalize with apolipoproteins and HCV RN

76 Recent work has established that even core protein components of the spliceosome, which are re

77 verse range of macromolecules, including the core protein components, the cytoplasmic lipid membrane,

78 uses cross-reacted with sera against the HBV core protein, concordant with the phylogenetic relatedne

79 Glypican core proteins consist of a stable alpha-helical domain c

80 Small molecules that target core protein (core protein allosteric modulators [CpAMs]

81 g other biosynthetic enzymes or proteoglycan core proteins could not account for the observed changes

82 ther, these results for C9 regulation by HCV core protein coupled with functional impairment of the m

83 The majority of the core protein (CP149) comprises the capsid assembly domai

84 ld-type core protein (Cp183-WT) and a mutant core protein (Cp183-EEE), in which three CTD serines are

85 We examined wild-type core protein (Cp183-WT) and a mutant core protein (Cp183

86 So far, only nine core proteins (CPGs) have been identified, some of which

87 (DHBc) was observed when the WT and most HBV core protein CTD (HCTD) variants were coexpressed in tra

88 V-B acclimation preserved the photosystem II core proteins D1 and D2 under UV-B stress, which mitigat

89 rs that may interact differentially with the core protein depending on its CTD phosphorylation state,

90 idues in the hydrophobic base of the capsid (core) proteins, designated motifs I, II, and III, are hi

91 This demonstrates the existence of core protein-determined HS sulfation patterns that regul

92 atic decrease in phosphorylation of the DHBV core protein (DHBc) was observed when the WT and most HB

93 roaryldihydropyrimidine (HAP) pocket between core protein dimer-dimer interfaces.

94 riptional DNA replication to take place, the core protein dimers, existing in several different quate

95 n the pre-genomic RNA with high affinity for core protein dimers.

96 The analysis of the core protein domain organization revealed that all chond

97 gh mechanisms largely thought to exclude the core protein domain.

98 leoprotein (snoRNP) complex that shares four core proteins, dyskerin (DKC1), NOP10, NHP2, and GAR1.

99 ocessing factors VTF/CE and NPH-I, the viral core protein E11, and host tRNA(Gln).

100 virus (HBV) or duck hepatitis B virus (DHBV) core protein, either the wild type (WT) or with alanine

101 rus (DHBV) and human hepatitis B virus (HBV) core protein, either with wild type (WT) sequences or wi

102 rker and a fluorescently tagged Vpr (a viral core protein) enables detection of single-virus fusions,

103 The hepatitis B virus (HBV) Core protein encodes a late (L)-domain like motif (129PP

104 and hydrophobic amino acids buried in their cores, protein engineers followed this rule exactly when

105 tion provided an "anchor" for the Abs as the core protein epitope varies, prevented complete neutrali

106 ing T cells to the pH1N1 virus and conserved core protein epitopes with clinical outcomes after incid

107 Beclin-1 (also known as Atg6 in yeast) is a core protein essential for autophagic initiation and oth

108 ng studies in C. elegans identified a set of core proteins essential for centriole duplication [6-12]

109 In this study, we report that HCV core protein, expressed in Huh7 and Madin-Darby canine k

110 HCV infection or core protein expression alone in transfected Huh7.5 cell

111 Further, HCV infection or core protein expression in Huh7.5 cells significantly de

112 virus (HCV) infection of hepatocytes or HCV core protein expression in transfected hepatocytes upreg

113 t hepatitis C virus (HCV) infection or virus core protein expression upregulates CD55 expression.

114 Cas4 proteins, a core protein family associated with the microbial system

115 sh complex, reduces junctional levels of the core proteins Flamingo and Strabismus in the developing

116 tifies other catalysts that contain a shared core protein fold but whose active sites are located in

117 Cullin3 (CUL3), a core protein for the CUL3-RING ubiquitin ligase complex,

118 tivity, attractant regulation, and its bound core proteins for days or more at 22 degrees C.

119 We next find that axis core proteins form homotetrameric (Red1) or heterotetram

120 E2 binds at the dimer-dimer interface of the core proteins, forms a new interaction surface promoting

121 Focusing on the key core protein Frizzled, we show that its stable junctiona

122 ions are able to redirect viral nucleocapsid core proteins from their sites of replication to the cel

123 Here, we show that 'axis core proteins' from budding yeast (Red1), mammals (SYCP2

124 Here we investigate core protein function during planar polarization of the

125 w the CTD phosphorylation state may modulate core protein functions but phosphorylation state-depende

126 fate determination, in vivo knockdown of PCP core proteins FZD3 and CELSR1-3 revealed severe maturati

127 hat the SG component UBAP2L [11, 12] and the core protein G3BP1 [5, 11-13] occupy different domains i

128 perinatally lethal mutation in the aggrecan core protein gene, cmd(bc) (Acan(cmd-Bc)), that deletes

129 Hepatitis B virus core protein has 183 amino acids divided into an assembl

130 The HCV core protein has been shown to directly interact with an

131 The syndecan-1 core protein has multiple domains that confer distinct c

132 Hepatitis B virus core protein has multiple roles in the viral life cycle-

133 55) epitopes of EV71 using hepatitis B virus core protein (HBc) as a carrier, designated HBc-E1/2.

134 iple subunits of the hepatitis B virus (HBV) core protein (HBc) assemble into an icosahedral capsid t

135 enesis were employed to demonstrate that HBV core protein (HBc) is a PLK1 substrate.

136 Whereas the hepatitis B core protein (HBc) VLP appears to be the most promising

137 HBV core protein (HBc), encoded by the HBV genome, may play

138 of multiple copies of a single protein, the core protein (HBc).

139 In contrast to MHBs, a VLV expressing HBV core protein (HBcAg) neither induced a CD8 T cell respon

140 ination did not induce antibodies to the HBV core protein (HBcore), the standard biomarker for HBV in

141 We have reported that HCV core protein (HCVc) manipulates human blood-derived dend

142 alation during CE is regulated by a group of core proteins identified originally in flies to coordina

143 The IFT-B core proteins IFT74 and IFT81 interact directly through

144 gomerization properties of hepatitis B virus core protein illustrate both the importance of C-termina

145 uring infection or ectopic expression of HCV core protein.IMPORTANCE Endoglin plays a crucial role in

146 east cancer susceptibility gene 1 (Brca1), a core protein in DNA-damage repair, was repressed by CtBP

147 inase ABC treatment that removes CS from its core protein in the chondroitin sulfate proteoglycans or

148 C16/B22 increases proteolytic processing of core proteins in A549 cells consistent with higher infec

149 n addition to identifying a new role for the core proteins in disassembly events, these data highligh

150 ent study, we have profiled each of the HSPG core proteins in HCV attachment.

151 ttachment protein receptors (SNAREs) are the core proteins in membrane fusion.

152 o measure the binding of mRNA export and EJC core proteins in nuclear complexes.

153 NV MR system for functional analysis of SYNV core proteins in trans and the cis-acting leader and tra

154 ities required expression of the N, P, and L core proteins in trans and were enhanced by codelivery o

155 psid particle p24) or HCV (hepatitis C virus core protein) in transplastomic tobacco.

156 The HSPG core proteins include the membrane-spanning syndecans (S

157 PRC1 complexes, each of which contains four core proteins, including one from the CBX family.

158 UBAP2L displays typical properties of a core protein, indicating that cores of different composi

159 st abundant envelope protein, VP24 acts as a core protein interacting with other structure proteins a

160 fic and suggest that cognate MP-nucleocapsid core protein interactions are required for intra- and in

161 egies against ATP6AP2, a recently discovered core protein involved in both signaling pathways, reveal

162 is a bacterial actin homolog and one of the core proteins involved in cell division.

163 Hence, HBV core protein is a dominant antiviral target that may sup

164 Though the hepatitis B virus (HBV) core protein is an important participant in many aspects

165 rboxyl-terminal domain (CTD) of hepadnavirus core protein is critical for viral replication.

166 in pNS3h that rescue viruses from which the core protein is deleted map to D3, suggesting that this

167 The hepatitis B virus (HBV) core protein is essential for HBV replication and an imp

168 The C-terminal domain (CTD) of hepadnavirus core protein is involved in multiple steps of viral repl

169 Since HCV core protein is one of the key players in metabolic regu

170 Accumulation of PSII core proteins is compromised under these conditions in t

171 subcellular asymmetries of Ft and Ds and the core proteins is largely independent in the wing disc an

172 fies the virion to release the viral RNA and core proteins is not well understood.

173 This asymmetric distribution of the core proteins is proposed to require amplification of an

174 In contrast, VP3, the other major structural core protein, is an essential component of the complex,

175 residue G33, located within domain 1 of the core protein, is important for the production of cell cu

176 roitin sulfate (CS) chain of bikunin, or the core protein itself, enables the bikunin proteoglycan (P

177 argely absent in the knockout mutant of PSII core protein kinase SER/THR PROTEIN KINASE8 (STN8).

178 stals of selenomethionine-labeled glypican-1 core protein lacking the HS domain.

179 We examined the functions of the core proteins lambda1 and sigma2.

180 When junctional core protein levels are either increased or decreased by

181 Loss of asymmetry by altered core protein levels can be explained by reference to fee

182 s through more than one mechanism to control core protein levels in Drosophila, and that without this

183 ymmetry appears to require the regulation of core protein levels, but the importance of such regulati

184 T decreases HBV replication and HBV mRNA and core protein levels.

185 suggest that the LDAF1-seipin complex is the core protein machinery that facilitates LD biogenesis an

186 , but recent reports have suggested that the core protein mammalian telomerase reverse transcriptase

187 t statistically significant levels, with the Core protein may drive virion assembly.

188 he membrane lytic protein VI molecules, this core protein may serve as a bridge from the inner dsDNA

189 We show that these core proteins may have a role in intra-cellular communic

190 s, these data highlight the possibility that core proteins may influence multiple stages of infection

191 nding site on the CD55 promoter impaired HCV core protein-mediated upregulation of CD55.

192 The archaeal Nop56/58 core protein mediates crucial protein-protein interactio

193 We have recently shown that HCV core protein mediates functional inactivation of the pro

194 glypican-1, not syndecan-1, is the dominant core protein mediating shear-induced NO production.

195 The impact of naturally occurring core protein mutations on antiviral activity correlates

196 3.6 A resolution with atomic models for ten core proteins, nearly all essential domains of its RNA,

197 ) built on the Newcastle disease virus (NDV) core proteins, NP and M, and containing two chimeric pro

198 containing the Newcastle disease virus (NDV) core proteins, NP and M, and two chimera proteins (F/F a

199 It is also a core protein of cholesterol gallstones.

200 Mutations at positions 70 and/or 91 in the core protein of genotype-1b, hepatitis C virus (HCV) are

201 he structural and functional analysis of the core protein of hepatitis B virus is important for a ful

202 Apolipoprotein B(100) (apoB), the core protein of low-density lipoprotein, is an autoantig

203 Here, we show that Ku70, a core protein of nonhomologous end-joining (NHEJ) repair

204 The core protein of perlecan was an exclusive component of t

205 annel-like (TMC) family, was identified as a core protein of the mechanotransduction complex in hair

206 However, expression of the core protein of versican, a major chondroitin sulfate pr

207 s may provide a new method of evaluating the core proteins of an organism.

208 g domain of chemoreceptors and are among the core proteins of chemosensory cascades.

209 ed on "synthetic" viruses in which the outer core proteins of different BTV serotypes are incorporate

210 he levels of cyt f (PetA) and cyt b6 (PetB), core proteins of the cyt b6f complex.

211 mixed lineage kinase domain like (MLKL), two core proteins of the necroptosis pathway, blocks crystal

212 HBc, the capsid-forming "core protein" of human hepatitis B virus (HBV), is a mul

213 Further analysis suggested that the HCV core protein or full-length (FL) genome enhanced CD55 pr

214 Perturbing APC/C activity by depleting a core protein or the adaptor proteins of the catalytic do

215 bsence of STN8 completely abolished all PSII core protein phosphorylation.

216 shifts that also led to an increase in PSII core protein phosphorylation.

217 ize, and encompass thousands of units of the core proteins Pil1 and Lsp1.

218 and virus-induced mechanisms, with the viral core protein playing an important role in steatosis deve

219 Further analyses indicated that HCV core protein plays a significant role in modulating the

220 antiviral agents against HBV.IMPORTANCE HBV core protein plays essential roles in many steps of the

221 The absence of planar cell polarity (PCP) core proteins Prickle1 and Prickle2 in individual cells

222 except for the absence of A19 and decreased core protein processing, they appeared to have a similar

223 rVN specifically bound to authentic versican core protein produced by dermal fibroblasts.

224 fation of the CS chain of bikunin and/or its core protein promote HC transfer by TSG-6 to its relativ

225 ear whether the SSR involves a common set of core proteins regardless of the type of stress or whethe

226 mount of heparan sulfate present on syndecan core proteins regulates both the rate of syndecan sheddi

227 ide triphosphate phosphohydrolase I, and two core proteins required for morphogenesis.

228 lizing and destabilizing interactions of the core proteins required for self-organization of planar p

229 smodium falciparum identified genes encoding core proteins required for the homologous recombination

230 he maturation of the hepatitis C virus (HCV) core protein requires proteolytic processing by two host

231 TGN membranes to closely associate with HCV core protein residing on lipid droplets.

232 that loss of HS biosynthesis or of the SDN-1 core protein results in misorientation of the spindle of

233 The crystal structure of the decorin core protein revealed a tight dimer formed by the associ

234 These core protein-RNA contacts may play one or more roles in

235 m interactions distributed unevenly across a core protein-RNA interaction network.

236 The system is composed of core proteins SecA2 and SecY2 and accessory Sec proteins

237 The interaction of DDX3X with HCV core protein seems to be dispensable for its proviral ro

238 ies yield insight into the interplay between core protein self-assembly and the host environment, whi

239 nique internal feature connected to the main core protein shell via lobes of density.

240 Yet many of its core proteins show evidence of rapid or adaptive evoluti

241 The ESCRT-III core protein Shrub has a central role in endosome-to-mul

242 Further studies suggested that HCV core protein significantly upregulates c-Kit expression

243 Mapping studies using gp120 core protein, single-residue knockout mutants, and chime

244 -rich C-terminal tail of the essential snRNP core proteins SmN/B/B'.

245 experiments and the crystal structure of the core protein Snu13p/15.5K bound to a fragment of the ass

246 We show that loss of phosphorylation of the core protein Strabismus in the Drosophila pupal wing inc

247 e junctional localization is promoted by the core proteins Strabismus, Dishevelled, Prickle, and Dieg

248 at the postenvelopment step and that the HCV Core protein strongly associates with the DRM, recruitme

249 typic diversity, generally do not affect the core protein structures and have no deleterious effect o

250 tatic, the other half is actively exchanging core protein subunits.

251 ary miRNAs (pri-miRNAs) and miRNA processing core proteins, such as Dicer-like 1, SERRATE, and HYPONA

252 e heparan sulfate chains present on syndecan core proteins suppress shedding of the proteoglycan.

253 d with HCV-infected hepatocytes, or with HCV core protein, suppress autologous T-cell responses.

254 sized that marked shedding of the glycocalyx core protein, syndecan-1, occurs in end-stage liver dise

255 s, which exhibited a marked depletion of HBV core protein synthesis and down-regulation of pre-genomi

256 lates both the rate of syndecan shedding and core protein synthesis.

257 ate is accompanied by a dramatic increase in core protein synthesis.

258 e selection of drug-resistant viruses during core protein-targeting antiviral therapy.

259 The discovery of novel core protein-targeting antivirals, such as benzamide der

260 protein VII, a virally encoded histone-like core protein that is suggested to protect incoming viral

261 Here we describe how a small adenovirus core protein that localizes to host chromatin during inf

262 een the viral pre-genome and the hepatitis B core protein that play roles in defining the nucleocapsi

263 structural proteins and composed of several core proteins that closely interact with the packaged ds

264 tion plus phylogenetic analyses of conserved core proteins that have just 20% to 50% or less identity

265 he shared, chaperone-bound scaffold of H/ACA core proteins that mediates initial RNP assembly.

266 we designed a structural mimic of AEf-bound core protein, the V124W mutant.

267 substantial decreases in the amounts of PSI core proteins, the content of 3Fe-4S-containing ferredox

268 nhibition of the function of individual PRC2 core proteins, the disruption of PRC2 complex formation,

269 driven by feedback interactions between the core proteins themselves.

270 lls replicating the virus with the wild-type core protein to determine the roles of CTD in viral repl

271 n sulfate enhances the susceptibility of the core protein to proteolytic cleavage by matrix metallopr

272 that heparan sulfate must be attached to the core protein to suppress shedding.

273 ns and the C-terminal domain that attach the core protein to the cell membrane are not resolved in th

274 HS is known to covalently attach to core proteins to form heparan sulfate proteoglycans (HSP

275 ing disaccharide units, covalently linked to core proteins to form proteoglycans.

276 RNPs) involves the sequential recruitment of core proteins to snoRNAs.

277 HCV-infected or core protein-transfected Huh7.5 cells displayed greater

278 hly flexible in solution, but it orients the core protein transverse to the membrane, directing a sur

279 Consistent with a role as a core protein, UBAP2L is required for SG assembly in seve

280 e, and unveil its associations with VIII and core protein V, which together glue peripentonal hexons

281 pected relationship between VI and the major core protein, VII.

282 e composed of a symmetrical capsid (built of core protein), viral pregenomic RNA, and viral reverse t

283 ined by immunohistochemical detection of the core protein VP1 of HPyV-6.

284 RNA, the viral polymerase VP1, and the inner core protein VP2.

285 rms the carboxy-terminal domain of the minor core protein VP3 (VP3-CTD) and shares sequence and predi

286 CSC generation by HCV core protein was dependent on the endoglin signaling pat

287 ic capsids from wild-type and drug-resistant core proteins was susceptible to multiple capsid assembl

288 uences of the assembly domain of WHV and HBV core proteins (wCp149 and hCp149, respectively) have 65%

289 m phage libraries and streptavidin/avidin as core protein were used for direct detection of small com

290 We tested a virus in which the core proteins were derived from a different strain than

291 A total of 124 and 42 core proteins were identified in betaC-plastoglobuli and

292 Retromer recognition core proteins were significantly decreased in DS fibrobl

293 f triacsin C, reduced stability of the viral core protein, which forms the virion nucleocapsid and is

294 containing Drosophila Vps8 and three shared core proteins, which are required for endosome maturatio

295 ival; it is composed of 12 mostly multimeric core proteins, which build a sophisticated secretion mac

296 of the association energy between individual core proteins, which is proportional to ionic strength.

297 link the anti-lipolytic activity of the HCV core protein with altered ATGL binding to CGI-58 and the

298 f the T4aPM and the location of 10 conserved core proteins within this architecture have been elucida

299 The exon junction complex core protein Y14 is required for nonsense-mediated mRNA

300 22, we found that eIF4AIII and the other EJC core proteins Y14 and MAGO bind the nascent transcripts