ライフサイエンスコーパス: core structure

1 peptide needs time to form and optimize the core structure.

2 hydroxyl moieties afforded upon a conserved core structure.

3 ors exhibiting repetitive sequences in their core structure.

4 that share a 4-methoxypyrrolyldipyrromethene core structure.

5 onent reaction generating the peptidomimetic core structure.

6 l aza-[4+2] cyclization to form the cagelike core structure.

7 ds uniquely embedded in each natural product core structure.

8 as exchange share a common 'Farquhaur-model' core structure.

9 ily defined by a conserved three-dimensional core structure.

10 cular interactions that maintain the amyloid core structure.

11 hydrate-based approach to build the bicyclic core structure.

12 -galactosidase) can be created from the same core structure.

13 a 4,5-diphenyl-1H-pyrrole-3-carboxylic acid core structure.

14 influence of disulfide bond formation on the core structure.

15 on, whereby (13)CO was incorporated into the core structure.

16 ain, generating a stacked alphabetabetaalpha core structure.

17 lective binding to a uniquely galactosylated core structure.

18 promote crystal packing without altering the core structure.

19 gonists based on a phenethylpiperazine amide core structure.

20 mbered according to the size of the enediyne core structure.

21 onent reaction (4CR) for the assembly of the core structure.

22 s, functional groups) inherent to the target core structure.

23 d dihydroxyketone with acid gave the desired core structure.

24 methane oxidation) is supportive of an open-core structure.

25 s role in the assembly of invadopodial actin core structure.

26 that connects the HlyIIC domain to the HlyII-core structure.

27 nt is directly computed from the dislocation core structure.

28 nsities that would correlate with a complete core structure.

29 would correlate with the capsid region of a core structure.

30 n lead to molecules with virtually identical core structures.

31 a new method for characterizing dislocation core structures.

32 the reactivity of lactivicin and beta-lactam core structures.

33 he preparations of abiotic and sesquiterpene core structures.

34 ctivity, although they could possess varying core structures.

35 damage at the metals by maintaining the NiFe core structures.

36 rick-shaped mature virions with well-defined core structures.

37 release rates and efficiencies from isomeric core structures.

38 eated with proton pump inhibitors having the core structure, 2-pyridyl-methylsulfinyl-benzimidazole.

39 Arylazopyrazole derivatives based on four core structures (4pzMe, 3pzH, 4pzH, and 4pzH-F2) and fun

40 on a 5-aminonaphthalen-1-yloxy nicotinamide core structure, 5-((3-amidobenzyl)oxy)nicotinamides offe

41 uctasporine (2) contains an unprecedented TD core structure: a pyrrolinium indolocarbazole core that

42 Our IR data provide evidence that similar core structures also comprise wild-type PrP(res).

43 For the construction of the tricyclic core structure, an unusual intramolecular and diastereos

44 TP, despite maintaining the canonical ATPase core structure and active site residues.

45 nsion of this chemical class, both modifying core structure and decorating benzamide moiety, was dire

46 ts has distinct peptide segments forming the core structure and features different aggregate morpholo

47 h, by grouping species with common fragments/core structure and mutual functional groups, using precu

48 idence that Q possesses a bis-mu-oxo diamond core structure and show that both bridging oxygens origi

49 e crystal structure shows the expected dimer core structure and significant conformational variations

50 omaterials of differing chemistries, and (3) core structure and surface chemistry both influence part

51 here is a notable lack of information on how core structure and surface chemistry may alter toxicity

52 Modifications in core structure and surface chemistry of manufactured nan

53 effects of twelve CNMs that differ in their core structure and surface chemistry to Daphnia magna ov

54 estigated how alterations in both the ligand core structure and the appended acrylic acid substituent

55 However, the core structures and conformational dynamics of ribosomes

56 odies recognized epitopes consisting of both core structures and lacto-N-neotetraose (LNnT).

57 tivity toward N-linked and O-mannosyl glycan core structures and that its brain-specific gene express

58 are found to have such closely related metal core structures and the results may increase understandi

59 ngements of the NTDs that yield a functional core structure, and (iii) supports capsid function durin

60 Both Arps contain a shared actin core structure, and each Arp contains multiple insertion

61 129 residue is deeply buried in the amyloid core structure, and its mutation strongly impacts aggreg

62 microtubules, acts to stabilize the axonemal core structure, and serves as a central hub for the regu

63 The four glycoforms share a common core structure, and the differences are related to the n

64 side moiety, they vary dramatically in their core structures, and they have different activity proper

65 In contrast, close contact between filament core structures ( approximately 50 A spacing) is observe

66 The salient features of this core structure are absolutely conserved between alphabet

67 alkaloids and its conversion to the atisine core structure are reported.

68 The native and recombinant core structures are all similar to the truncated bacteri

69 nvestigated imine/R-TRIP complexes, the four core structures are highly preserved.

70 Thus, these core structures are independent of electron density and

71 ions adjacent to helix F, showing that their core structures are similar.

72 exes is large and the variations of the four core structures are small.

73 ain (FUS-LC-N, residues 2-108) have the same core structure as fibrils formed by the full-length LC d

74 The aim of TRFolder-W is to use the five core structures as fundamental units to predict potentia

75 The (mu-oxo)(mu-1,1-peroxo)diferric core structure associated with CmlI(P) is unprecedented

76 For that purpose, a UV-light-responsive core structure based on diaminopyrimidines with suitable

77 h lipopolysaccharide (R-LPS) with a complete core structure (beta-d-Glcp-(1-->4)-alpha-Kdop-(2-->4)[b

78 vacuolar pigments composed of a nitrogenous core structure, betalamic acid [4-(2-oxoethylidene)-1,2,

79 onovalent Smac mimetics with a diazabicyclic core structure bind to XIAP, cIAP1, and cIAP2 with low t

80 thout any stabilizing mutations had the same core structure, but revealed new insights and features.

81 he C2 side chain attached to the macrocyclic core structure by a C-C single bond, in place of the syn

82 bartoloside biosynthesis constrained the DAR core structure by defining key pathway intermediates, ul

83 The number of rings added to the GDGT core structure can vary as a function of environmental c

84 All steps yielding to the linear core structures can be conveniently coupled without the

85 en compared to those with the peptidolactone core structure common to two ADEP natural products.

86 This N-glycan core structure, common to all chloroviruses, is a pentas

87 nto a thermodynamically highly stable fusion core structure composed of six antiparallel alpha-helice

88 s and nucleosomal DNA through one arm of the core structure, composed of the Rsc8 SWIRM domains, Sfh1

89 om complex GSLs with lacto- and globo-series core structures comprising the well-known human pluripot

90 nt of E. coli R-LPS structures with isomeric core structures confirmed the degree to which subtle str

91 The AAV9 viral protein (VP) has a conserved core structure, consisting of an eight-stranded, beta-ba

92 The core structure, consisting of residues 77-186, consists

93 the LPS from the waaL strain showed that the core structure consists of L-glycero-D-manno-heptose, D-

94 NMR analyses showed that the core structure contains a furan ring.

95 e library comprises 10 discrete heterocyclic core structures derived from 1,3- and 1,5-dipoles; while

96 An alpha-amino acid-based core structure, derived from a hydantoin core, with uniq

97 early transcription is coupled to the viral core structure, detailing the structure of the nucleocap

98 first evidence that external O-glycans, with core structures distinct from N-glycans in type and numb

99 neO motif, though further modulations of the core structure due to the protein environment cannot be

100 proach allows us to accomplish the tricyclic core structure efficiently from readily available starti

101 7a that has a relatively rigid cyclopentene core structure exhibits the strongest inhibitory activit

102 ach to chiral bridged tricyclic benzopyrans, core structures featured in various natural products, is

103 dorsal anterior cingulate cortex (dACC) is a core structure for the governing of cognitive control, a

104 results presented show the importance of the core structure for the profile of the final compounds.

105 However, the lack of a core structure for vortex filaments appears to result in

106 magnesium oxide can exhibit polymorphism of core structures for a given dislocation species.

107 The fibrils have a common rod-like core structure, formed from an elongated stack of beta-s

108 ,2,3,4-tetrahydro-9a,4a-iminoethanocarbazole core structure found in the alkaloid minfiensine (2).

109 a method that enables direct access to these core structures from non-conjugated alkenyl amides and o

110 e extensions serve to shield conserved inner core structures from recognition by host immune componen

111 d to be unable to close the six-helix bundle core structure fully.

112 ic natural product composed of a tetracyclic core structure further elaborated with a p-methoxyphenyl

113 An [Fe(IV)(2)(mu-O)(2)] diamond core structure has been postulated for intermediate Q of

114 This type of core structure has relevance to the oxygen-evolving comp

115 [3,2,1-hi]indole and pyrrolo[3,2,1-hi]indole core structures has been designed and was synthesized by

116 Access to elongated core structures has now been achieved by the reaction of

117 ed lengths, and the axoneme, which forms the core structure, has exceptionally high stability.

118 Proteinaceous materials based on the amyloid core structure have recently been discovered at the orig

119 Synthetic studies toward these challenging core structures have revealed a number of unanticipated

120 es that it contains a cyanine-based cationic core structure identical to thiazole orange.

121 d the shared beta-alpha-beta-beta-alpha-beta core structure identified SPI-1 as a member of the I9 in

122 virus particles possessing a complete capsid core structure.IMPORTANCE Studies of retroviral particle

123 microscopy, we resolve the basal dislocation core structure in Bi(2)Te(3), quantifying the disregistr

124 imization by modifying the rings A-C and the core structure in further SAR studies.

125 ino[d]isothiazolone or benzo[d]isothiazolone core structure in lieu of the dimethylpyridine-fused iso

126 Axial core structure in non-replicating chromosomes is predomi

127 D)LCu(I)-CO possess the same four-coordinate core structure in solution with the variable D moiety "d

128 Aminodibenzazepinone 1, the core structure in the gamma-secretase inhibitor LY411575

129 of 4R tau and 3R tau share a highly ordered core structure in the third repeat with parallel, in-reg

130 All clamp loaders share a core structure in which five subunits form a spiral cham

131 te reactivity, while the preservation of the core structures in conjunction with extensive pi-pi and

132 n electron microscopy can reveal dislocation core structures in high detail, particularly in annular

133 or antibiotics, assembly of their polyketide core structures in nature remains poorly understood.

134 howed that a leucinol moiety attached to the core-structure in the 7-position together with alpha-met

135 optimize packing densities in the fibrillar core structure, in contrast to those forming wide amyloi

136 noparticles that are comprised of a membrane/core structure including a surface-grafted polyethylene

137 They also share catalytic core structures, including the heme-binding site.

138 e recognition of the analytes' small generic core structure is a demanding task due to limited space

139 The arylmethylsulfonylpyrrole core structure is a new pharmacophore for hGSTA1-1, wher

140 The Ste24p core structure is a ring of seven transmembrane helices

141 In this approach, a core structure is constructed via proline-catalyzed Mann

142 layers present special interest since their core structure is controlled by the van der Waals intera

143 h to the synthesis of the (iso)cyclocitrinol core structure is described.

144 This unexpected core structure is explained by a strong coupling of the

145 The core structure is highly homologous to other members of

146 s have a unique nanostructure in that a soft core structure is rigidized with a silane reagent, while

147 The core structure is scaffolded by an asymmetric Rsc8 dimer

148 The core structure is simple and symmetrical, yet provides a

149 The core structure is the ~4 MDa needle complex (NC), built

150 eaturing a unique 5,6,5,12-fused tetracyclic core structure, is the major component of spinosad, an o

151 the bicyclic templates and the nature of the core structure itself have a significant impact on the c

152 e proteins to create a series of DNA/histone core structures known as nucleosomes; these are further

153 The core structure, like that from other phages, is cone sha

154 ore chromophores; however, alteration of the core structure may be the actual source of energy dissip

155 Unusual dislocation core structures may be present in other technologically

156 ted synthesis, wherein stereochemically rich core structures may be reorganized into chemotypes that

157 mpounds tetrahydropyrans (THPs) constitute a core structure of a wide array of bioactive natural prod

158 rious non-natural nucleosides that mimic the core structure of adenosine to modulate drug resistance

159 me how a long saturated chain can fit in the core structure of an acyltransferase domain through a de

160 he effects of the benzylic leaving group and core structure of arylboronates on H2O2-induced formatio

161 In addition, the chiral core structure of Au(11)L(4)X(2)(+) is not sufficient to

162 ditions were applied to the synthesis of the core structure of BIIB042, a gamma-secretase modulator,

163 e and its elaboration to a model tetracyclic core structure of calyciphylline B-type alkaloids.

164 re self-reproducing organelles that form the core structure of centrosomes or microtubule-organizing

165 being a member of the Tombusvirus genus, the core structure of CNV is highly similar to that of Tomat

166 ter variations, and nontrivial handle-shaped core structure of defects.

167 is shown by the expeditious synthesis of the core structure of diclofensine.

168 The core structure of dislocations in sapphire introduced by

169 teps at 3D twin boundaries and imaged the 3D core structure of edge and screw dislocations at atomic

170 Sequence alignment inferred that the core structure of fungal GH26 endomannanases differ depe

171 monstrated through a concise approach to the core structure of glaciolide and formal syntheses of fra

172 144) protofilament is similar to the amyloid core structure of HuPrP(112-141) predicted by Zweckstett

173 The skin-core structure of Kevlar(R) 29 fiber was revealed throug

174 The asymmetric synthesis of the core structure of leucosceptroids A-D has been achieved.

175 Biochemical assays revealed clues that the core structure of LF3 was essential for inhibition.

176 biological assays show that rigidifying the core structure of loratadine and related analogues throu

177 rongest to mutants lacking the O-antigen and core structure of LPS, but still exposing lipid A on the

178 Arylamines constitute the core structure of many therapeutic agents, agrochemicals

179 S), we show that Abeta1-40 aggregates at the core structure of mature plaques, whereas Abeta1-42 loca

180 we characterize the six-helix bundle fusion core structure of MERS-CoV spike protein S2 subunit by X

181 The core structure of MICU2 is very similar to that of MICU1

182 es reveal much about the exquisite hexameric core structure of Orai channels.

183 The core structure of Ran, outside the COOH tail, is not alt

184 f two adjacent beta-propellers that form the core structure of Sro7.

185 domain of FIN219 alters ATP binding and the core structure of the active site.

186 was demonstrated in a short synthesis of the core structure of the Aspidosperma alkaloid jerantinine

187 ytic system has been developed modifying the core structure of the bipyridine.

188 ion to construct the third ring found in the core structure of the cladiellins.

189 from the human posteromedial cortex (PMC), a core structure of the default mode network, during vario

190 lowing us to propose a possible model of the core structure of the fibrils.

191 ocused on this triazolopyrazine as it is the core structure of the in vivo active antiplasmodium comp

192 The monotwinned inner core structure of the ligand capped Au(191) nanomolecule

193 ilin inhibitors was synthesized based on the core structure of the natural product sanglifehrin A.

194 hesis of the hydrobenzofuro[3,2-b]chromenone core structure of the natural products sanggenon A and s

195 n of the Delta(6,7)-double bond found in the core structure of the natural products.

196 Alternatively, the core structure of the polyQ fibrils might also be a zipp

197 was elaborated to form the hydroxypiperidine core structure of the pseudodistomin alkaloids.

198 on of a cross-conjugated pentadienone to the core structure of the rocaglate natural products has not

199 How the huge core structure of the SPB is anchored in the NE has not

200 to cleave the polyproteins so that the final core structure of the virus will properly form.

201 core structure, we obtain the heterogeneous core structure of the weighted network, which is called

202 nding domain have deleterious effects on the core structure of the Z-discs in skeletal muscle.

203 e topology in the appearance, stability, and core structure of these defects remains poorly understoo

204 The core structure of thiomuracin exhibits similar antimicro

205 in I, and troponin C, indicating a preserved core structure of TnT.

206 been previously described as a DBP, and its core structure of tribromoethene has been demonstrated t

207 the Galbeta1-4GlcNAc motif, which forms the core structure of type II glycans and is the precursor o

208 of the Delta (6, 7)-double bond found in the core structure of vindoline and defined our use of a pro

209 study, we developed a method to extract the core structure of weighted heterogeneous networks by tra

210 iving force for heterodimer formation is the core structure of ZnTs and not the BiFC tags.

211 ghly functionalized quinolines including the core structures of an antiprotozoal agent and the potent

212 Scaffolds are mostly used to represent core structures of bioactive compounds.

213 Cyclic amines are ubiquitous core structures of bioactive natural products and pharma

214 e moieties which enabled rapid access to the core structures of curcumanolide A and curcumalactone.

215 ine and indolopyrazine ring systems form the core structures of distinct members of biologically sign

216 The core structures of DRAs are formed in secondary (i.e. sp

217 ion dynamics by tailoring the bi-tetrahedral core structures of gold nanoclusters.

218 stematically determine, analyze, and compare core structures of kinase inhibitors.

219 g while simulations corroborate these stable core structures of Luciferase, and indicate the relative

220 gen heterocycles would provide access to the core structures of many natural products and pharmaceuti

221 Here we report the core structures of Q and the following product complex,

222 The formation of Sm core structures of spliceosomal U-rich small nuclear rib

223 lder-W is a web server capable of predicting core structures of telomerase RNA (TR) in yeast genomes.

224 r the subgenual anterior cingulate and other core structures of the CSPTC.

225 nance of chromosome (SMC) proteins forms the core structures of three multisubunit complexes as follo

226 demonstrated in the concise syntheses of the core structures of vincorine, isocorymine, and aspidophy

227 namics simulations on the entire, as well as core, structure of bovine CcO in a lipid-solvent environ

228 three and seven position of the beta-lactam core structure on the electrochemical fingerprint, were

229 s are compatible with a precisely positioned core structure, one in which each of the 16 yeast centro

230 e natural products that often constitute the core structures or complete chemical entities for many c

231 No prior knowledge of core structures or R-groups is required, which are autom

232 ve-membered ring fused bicyclic lactone, the core structure present in gracilioether F.

233 n of a reaction product to yield a tricyclic core structure, present in various natural products.

234 osyl, and methyl groups about their aromatic core structure produced distinguishable H/D exchange pat

235 LCK appears to be intrinsic to its catalytic core structure rather than an autoinhibitory segment.

236 accumulated about the morphology and fibril-core structure recently.

237 tebrate and invertebrate TnTs have conserved core structures, reflecting conserved functions in regul

238 The core structures represent new structural motifs for FGFR

239 he target focusing on docking poses with the core structure resembling a known bioactive conformation

240 ings indicate that the twin-His motif is the core structure responsible for substrate deprotonation a

241 apparent lack of effect on the polyQ fibril core structure seem surprising.

242 ment of an enantioselective route toward the core structure shared by all members of the stolonoxide

243 formations sampled by these multiple "gyrase(CORE)" structures show rigid body movements of the catal

244 f a polyglutamic acid side chain linked to a core structure similar to the one present in archaeal me

245 from a continuum-mechanical description, via core-structure simulation, to their full experimental ch

246 age to the basal ganglia have indicated that core structures, such as the cortico-thalamic-basal gang

247 y, can form a stable six-helix bundle fusion core structure, suggesting that MERS-CoV enters into the

248 tibodies was affected by modification of the core structure, suggesting that these functional antibod

249 uggest that stress granules contain a stable core structure surrounded by a dynamic shell with assemb

250 and contain a biphasic structure with stable core structures surrounded by a less concentrated shell.

251 Unexpectedly, MHV NTD contains a core structure that has the same beta-sandwich fold as h

252 e an extensive statistical evaluation of the core structure that is inherent to all gene- set analyse

253 human DGAT-1 led to the identification of a core structure that was subsequently optimized to afford

254 ctures reveals conformational changes in the core structure that will enable future deployment of thi

255 Cycloalkane[d]isoxazoles form new core structures that interact with the hydrophobic regio

256 cal synthesis, KIIIA analogues that had as a core structure the disulfide-depleted KIIIA[C1A,C2U,C9A,

257 seven amide bonds central to the vancomycin core structure, the approach relied on two aromatic nucl

258 strain-dependent, solvent-inaccessible beta-core structures throughout most of the C-terminal half o

259 This DNA frame is used as a core structure to organize other functional materials in

260 This work sheds light on the amyloid core structures underlying prion strains and how I138M,

261 r both states and (2) a change to the diiron core structure upon reduction.

262 of CDK9, its cellular functions, and common core structures used to target CDK9, along with their se

263 kinetic resolution of the tetrahydroxanthone core structure using homobenzotetramisole catalysis and

264 demonstrate the viability of forming indane core structures using this approach.

265 roducts share a common uridine moiety, their core structures vary substantially and they exhibit diff

266 s-degrees in decreasing order to obtain the core structure via the h-index of a base-homogeneous-net

267 wo flanking integrase dimers that engage the core structure via their integrase carboxy-terminal doma

268 The carbocyclic core structure was assembled using a tandem phenolic oxi

269 Each of these core structures was then extended to up to 11 HMOs by 4

270 en the attribute nodes and base-nodes to the core structure, we obtain the heterogeneous core structu

271 oducing adaptive elements into the inhibitor core structure, we undertake the structure-based develop

272 the 7-amino-5-thio-thiazolo[4,5-d]pyrimidine core structure, we were able to achieve compounds with h

273 uct alangiobussinine and the marinacarboline core structure were functionalized using carboline-direc

274 smodium vivax (Pv) SHMT with a pyrazolopyran core structure were identified.

275 Forty-four substituted derivatives of this core structure were synthesized using a variety of benza

276 te (LCP) nanoparticles (NPs) with a membrane/core structure were used to encapsulate ACVP to facilita

277 the basis of 3 versatile building blocks, 3 core structures were chemically synthesized via consiste

278 sing automated glycan assembly, these common core structures were constructed and elaborated to acces

279 allic acid substituted compounds, of diverse core structure, were characteristic of the phytochemical

280 Cu(I) series possess an identical tridentate core structure where the cuprous ion binds to the bispic

281 nds ThT, is ultrastable, and has a fibrillar core structure, whereas necrosis is partially inhibited

282 tetrameric form contained a D(2d)-symmetric core structure, whereas the dimers were determined exper

283 discovered a tobramycin-moxifloxacin hybrid core structure which enhances outer membrane permeabilit

284 ormed extensive modifications on its pyrrole core structure, which has culminated in the discovery of

285 erium and contain a bicyclic phosphotriester core structure, which is a rare motif among natural prod

286 y stable assembly of untranslated mRNPs into core structures, which could provide sufficient high loc

287 ch for active compounds containing different core structures, which is a topic of high interest in me

288 gram scale synthesis of a versatile bicyclic core structure with a high degree of stereoretention.

289 s showed that both species possess a diamond core structure with a short Co...Co distance of 2.78 ang

290 MOHQ may be rationalized by invoking an open-core structure with a terminal Fe(IV) horizontal lineO m

291 e intermediate possesses a di-mu-oxo diamond core structure with a terminal hydroxide ligand to the M

292 el antiestrogens based on a simple adamantyl core structure with acrylate side chains optimized for c

293 extensive superfamily of PGTs that reveals a core structure with dual domain architecture featuring a

294 ituent amino acids within the peptidolactone core structure with more conformationally constrained co

295 rA3G-CD1 shares a conserved core structure with the previously determined catalytic

296 s spp. bearing the bicyclo[2.2.2]diazaoctane core structure with unusual structural diversity represe

297 f these metabolites arises by conjugation of core structures with diverse chemical moieties, such as

298 MCF, offering flexibility to fabricate dense core structures with same cladding diameter.

299 lso find samples with a truncated decahedral core structure, with some samples exhibiting a coexisten

300 d platform, a general shared decision-making core structure would accommodate simple, interchangeable