ライフサイエンスコーパス: coreceptor

1 ss sensitive, even in the absence of the CD8 coreceptor.

2 sts, it is possibly not due to its role as a coreceptor.

3 gh viral adaptation to use a drug-bound CCR5 coreceptor.

4 acement of filamentous actin from the CD4(+) coreceptor.

5 ily called GFRAL and signals through the Ret coreceptor.

6 ipoprotein receptor-related protein 4 (LRP4) coreceptor.

7 on of NgR1 with CRMP2 requires PlexinA2 as a coreceptor.

8 from a donor carrying a mutation in the CCR5 coreceptor.

9 cking Abs act predominantly through the CD28 coreceptor.

10 e analogue that potently blocks the HIV CCR5 coreceptor.

11 specific ABA receptors or deficiency of ABA coreceptors.

12 protein (Env) and cellular CD4 receptors and coreceptors.

13 We cloned sabaeus CD4 and 10 candidate coreceptors.

14 p120 that allow high-affinity binding to its coreceptors.

15 y superantigens does not require CD4 and CD8 coreceptors.

16 strong for cells with low surface density of coreceptors.

17 inhibitory receptors, as well as modulating coreceptors.

18 us interactions with both the CXCR4 and CCR5 coreceptors.

19 to peptide-MHC ligands together with CD4/CD8 coreceptors.

20 h is further strengthened in the presence of coreceptors.

21 ssential step in Hedgehog signaling, whereby coreceptors activate SHH by chaperoning it from a latent

22 Wnt binding to its coreceptors activates the cytosolic effector Dishevelled

23 hough these DN thymocytes fail to re-express coreceptors after OP9-DL1 culture, they eventually matur

24 markers TNF-alpha and IL-6, as well as viral coreceptor agonist MIP1alpha, which correlated with redu

25 hese cells in terms of TCR signaling, use of coreceptor and costimulatory molecules and their develop

26 1 forms a complex with a shape-complementary coreceptor and initiates a signal transduction cascade,

27 It acts as an inhibitory coreceptor and modulates B cell activation, especially o

28 ts of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.

29 upled receptor (GPCR) that serves for an HIV coreceptor and was also recently found as a novel homing

30 The Arabidopsis genome encodes nine PP2C coreceptors and 14 different RCARs, which can be divided

31 ent or non-Smad pathways and is modulated by coreceptors and by interacting networks.

32 n of alphabeta T cells that lack CD4 and CD8 coreceptors and contribute to systemic lupus erythematos

33 ia enhanced surface retention of the CD4/CD8 coreceptors and limiting TCR clustering/signaling, respe

34 , instead, processes in the thymus involving coreceptors and other molecules select MHC-specific TCRs

35 et a host cell protein, CCR5, an HIV-1 entry coreceptor, and not viral protein.

36 highlight the modulatory role of NRP1 as MET coreceptor, and they explain how some snake venoms induc

37 Moreover, the early use of coreceptor antagonists against the remaining CCR5-tropic

38 These coreceptors are both positive regulators of T cell activ

39 Parallel recruitment of coreceptor-associated Lck kinase to the TCR ensured Zap7

40 ts heterologous expression together with the coreceptor AtGET1 rescues growth defects of Deltaget1get

41 ly, a dominant mutant (axr2-1) for the auxin coreceptor AUXIN RESPONSIVE2 (AXR2) was strongly suppres

42 elf26 and AtPep1, which are perceived by the coreceptor BAK1 and cognate PM receptors.

43 ired the common receptor-like protein kinase coreceptor BAK1.

44 aran sulfate proteoglycan were implicated as coreceptors because only the combination of anti-DC-SIGN

45 ls along with FGF receptors and its obligate coreceptor, betaKlotho.

46 can coordinately suppress both receptor and coreceptor binding and conformationally entrap the prote

47 D4-induced conformational changes leading to coreceptor binding and fusion, and HIV-1 Env conformatio

48 CD8 coreceptor binding and lymphocyte-specific kinase signal

49 e cell membrane can be inhibited by blocking coreceptor binding or by preventing fusion-inducing conf

50 essibility of bNAb epitopes in the CD4bs and coreceptor binding region, thus representing a potential

51 These Abs, including anti-coreceptor binding site (CoRBS) and anti-cluster A antib

52 ies (nnAbs) such as those that recognize the coreceptor binding site (CoRBS).

53 in HIV-positive (HIV(+)) sera, such as anti-coreceptor binding site and anti-cluster A antibodies.

54 mponent of the Env trimer contributes to the coreceptor binding site and is a target for neutralizing

55 der of conformational changes on the path to coreceptor binding site exposure and subsequent viral-ho

56 is active and allowing mapping of the native coreceptor binding site on pMHC II.

57 ycoproteins on these HIV-1 variants expose a coreceptor binding site that overlaps some CD4-induced (

58 (CD4) and an antibody (36D5) at part of the coreceptor binding site, we visualized multiple conforma

59 o resolve a Zn(2+) metal ion adjacent to the coreceptor binding site, which affected the structural s

60 ts its neutralization effect by blocking the coreceptor binding site.

61 Ab epitopes in V3 and/or associated with the coreceptor binding site.

62 earrange and separate to allow access to the coreceptor binding site.

63 on that the antigenicity of the receptor and coreceptor binding sites can be modulated by a single gl

64 as insensitive to actin inhibitors, post-CD4/coreceptor binding steps during FFWO were abrogated.

65 ved CD4-induced epitope on gp120 involved in coreceptor binding.

66 i) antibodies, which recognize the conserved coreceptor-binding site of the HIV-1 envelope glycoprote

67 nce, 10-1074 does not induce exposure of the coreceptor-binding site, and addition of mim6 to 10-1074

68 auses gradual and reversible exposure of the coreceptor-binding site.

69 The CD4- and coreceptor-binding sites serve as epitopes for two class

70 ing between prefusion-closed, CD4-bound, and coreceptor-bound conformations by transitioning into a p

71 ore activating Y394 phosphorylation than the coreceptor-bound Lck pool.

72 ated higher T cell activation as compared to coreceptor-bound Lck.

73 Lck is present either in coreceptor-bound or coreceptor-unbound (free) forms, and

74 with reduced PM accumulation of FLS2 and its coreceptor BRASSINOSTEROID INSENSITIVE1-ASSOCIATED RECEP

75 signaling by lipid-anchored NgR1 requires a coreceptor but the relevant partner in vivo is not clear

76 id differentiation protein 2 (MD2) is a TLR4 coreceptor, but its role in pollen- and cat dander-induc

77 species-matched CXCR6 and other alternative coreceptors by SIVagmSab, which infects sabaeus AGM.

78 tilization was observed, indicating that the coreceptor can compensate for TbpA impairment.

79 ing dualistic enhancing or dampening inputs, coreceptors can engage concomitant stimulatory and inhib

80 p120 binds to CD4, the HIV-1 receptor, and a coreceptor, capturing an open conformational state in wh

81 y lipoprotein receptor-related protein 5 Wnt coreceptor causes constitutive activation of Wnt signali

82 sed and secreted), the ligands for HIV entry coreceptor CC chemokine receptor type 5.

83 donor with a homozygous mutation in the HIV coreceptor CCR5 (CCR5Delta32/Delta32) to treat his acute

84 Genetic disruption of the HIV-1 coreceptor CCR5 by nucleases in T cells is under 2 clini

85 IV) have been described that can utilize the coreceptor CCR5 or CXCR4 in the absence of CD4, these vi

86 ntry inhibitor drug maraviroc makes the cell coreceptor CCR5 unavailable for use by HIV-1 and is now

87 erse transcriptase, protease, integrase, and coreceptor CCR5 with EC50's ranging from 0.9 to 1.5 muM.

88 HIGH) CD4(+) T cells, do not express the HIV coreceptor CCR5 yet serve as a latent reservoir in GCs.

89 press very low levels of the canonical entry coreceptor CCR5, and recent studies have shown that CCR5

90 R3(+) cells preferentially expressed the HIV coreceptor CCR5, and vaccine-induced CXCR3(+)CXCR5(+) ce

91 memory CD4(+) T cells often express the HIV coreceptor CCR5, are significantly more proliferative, a

92 hosts have very low levels of the SIV entry coreceptor CCR5, suggesting that restricted entry may li

93 All T/F viruses used coreceptor CCR5, while no T/F viruses used CXCR4 or GPR1

94 frequency of CD4(+) cells expressing the SIV coreceptor CCR5.

95 +) FoxP3(+) CD4(+) T cells expressed the HIV coreceptor CCR5.

96 the viral entry receptor CD4 as well as the coreceptors CCR5 and CXCR4 from the surface of HIV-infec

97 , including the viral entry receptor CD4 and coreceptors CCR5 and CXCR4.

98 HIV-1 requires the CD4 receptor and a coreceptor (CCR5 [R5 phenotype] or CXCR4 [X4 phenotype])

99 inal homing (beta7hi), activation, and HIV-1 coreceptor (CCR5) expression in peripheral blood.

100 ing triggers conformational changes allowing coreceptor (CCR5) recognition through CCR5's tyrosine-su

101 ription/translocation or blockade of TLR4 or coreceptor CD14 on donor TRAMs prevented neutrophil recr

102 nhibition of complement component C5 and TLR coreceptor CD14 on heme-induced thromboinflammation in a

103 nally, antibodies against TLR2, TLR4, or the coreceptor CD14 reduced the profibrotic responses of ure

104 d expression of TLR4, its adaptor MyD88, and coreceptors CD14 and MD2.

105 by the TLRs, either directly or via the TLR4 coreceptors CD14 and MD2.

106 educed surface expression of the pre-BCR/BCR coreceptor CD19 and promoted spontaneous death of pre-B

107 ceptors on the B-cell surface, including the coreceptor CD19.

108 as taken to identify the interactomes of the coreceptors CD2 and CD28.

109 -particle tracking, we show how the negative coreceptor CD22 works with the cortical cytoskeleton in

110 modulation of the function of the inhibitory coreceptor CD22.

111 report the influence of signaling domains of coreceptors CD28 and 4-1BB on the metabolic characterist

112 T cells from CCI patients in response to TCR/coreceptor (CD3/CD28) challenge.

113 The alphabeta T-cell coreceptor CD4 enhances immune responses more than 1 mil

114 Like the TCR coreceptor CD4, WC1 is endocytosed in response to PMA.

115 T cells expressed memory markers and the HIV coreceptors CD4 and CCR5; they were not detected in subj

116 human monoclonal antibodies (HMAbs) and the coreceptor CD81 to confirm preservation of epitope struc

117 ion, killing stimulatory receptor Ly49s6 and coreceptor CD8alphaalpha on this cell used rat nonclassi

118 The coreceptor CD8alphabeta can greatly promote activation o

119 -cadherin ligation and involves the cadherin coreceptor Cdo with its downstream effector, Cdc42.

120 H requires a molecular relay mediated by the coreceptors CDON/BOC and GAS1, which relieves SHH inhibi

121 eptor cluster of differentiation 4 (CD4) and coreceptors chemokine receptor type 5 and chemokine-rela

122 ctor H, blocked B cell activation by the BCR coreceptor complex (CD19/CD21/CD81).

123 ates to the F-box protein COI1-JAZ jasmonate coreceptor complex and suggest that coincidence detectio

124 Auxin is perceived by a transient coreceptor complex consisting of a TIR1/AFB protein and

125 nd CD21 and preventing colocalization of the coreceptor complex with the BCR.

126 HSCs treated with the key RET ligand/coreceptor complex, glial-derived neurotrophic factor an

127 extracellular epitopes of the HCV CD81-CLDN1 coreceptor complex.

128 ppression and whether association with other coreceptor complexes is needed have remained unknown.

129 ort that formation of the pre-fusion Env-CD4-coreceptor complexes triggers non-apoptotic cell surface

130 luenced by both auxin accumulation and F-box coreceptor concentration.

131 pon sequential binding of Env to CD4 and the coreceptor CXCR4 or CCR5.

132 from PLWH on suppressive ART, the use of the coreceptor CXCR4 was prevalent among viruses amplified f

133 structures, typically those that utilize the coreceptor CXCR4.

134 cells express different levels of the viral coreceptors CXCR4 and CCR5 on their surface, we sought t

135 udy, we demonstrate the efficient use of the coreceptor CXCR6 by SIVagmSab to infect sabaeus African

136 fection is mediated by the alternative entry coreceptor CXCR6, as well as CCR5.

137 Conversely, in MHC and CD4/CD8 coreceptor-deficient mice, the thymus generates mature T

138 reased scavenger receptor class B type I HCV coreceptor dependency, both in an HVR1-dependent fashion

139 decreasing scavenger receptor class B type I coreceptor dependency.

140 r is a concern for therapies applying single-coreceptor disruption.

141 interacts with the primary receptor CD4 and coreceptor (e.g., chemokine receptor CCR5 or CXCR4) to a

142 o revealed losses of negative-regulatory TCR coreceptors (eg, CTLA4).

143 taneously emulate the HIV-1 receptor CD4 and coreceptors, either CCR5 or CXCR4.

144 D8(+) T cells can, in the absence of the CD8 coreceptor, elicit CD4 T cell help and partially reverse

145 cells, are missing for the endothelial cell coreceptor endoglin and for the ALK1 type I receptor, wh

146 but also, critically, by promoting B7-2/CD28 coreceptor engagement, forcing the principal costimulato

147 ested downstream of CD4 binding but prior to coreceptor engagement.

148 Although the introduction of the CD8 coreceptor enhanced the ability of CD4(+) T cells to rec

149 x, glial-derived neurotrophic factor and its coreceptor, exhibit improved progenitor function at prim

150 CD28 is a coreceptor expressed on T lymphocytes.

151 e members of the Siglec family of inhibitory coreceptors expressed on B cells that participate in enf

152 CD4-independent HIV-1 variants can infect coreceptor-expressing cells lacking CD4.

153 st-selected double-positive cells lose CD4/8 coreceptor expression and masquerade as double-negative

154 ssion status, downregulates HIV receptor and coreceptor expression and may reduce susceptibility of i

155 Inhibitory coreceptor expression on these cells corresponded to the

156 ne their effects on cellular activation, HIV coreceptor expression, and innate restriction factor exp

157 f these cell types can lack both CD4 and CD8 coreceptor expression.

158 re observed, along with elevated CD5 and CD8 coreceptor expression.

159 ase binding to MHC class I tetramers and CD8 coreceptor expression.

160 ENG (endoglin) is a coreceptor for BMP (bone morphogenetic protein) 9/10 and

161 sistent with the current views that HJV is a coreceptor for BMP6 in hepatocytes.

162 Neuropilin 1 (Nrp1), a coreceptor for class 3 semaphorins and growth factors, i

163 t neuropilin 1 (Nrp1), an originally defined coreceptor for class 3 semaphorins and VEGF, plays impor

164 ng sites identified betaKlotho, an essential coreceptor for FGF21, as a direct target gene of Rev-erb

165 Membrane-bound Klotho acts as a permissive coreceptor for FGF23, and its expression was recently fo

166 ne-bound protein (mKL) and recognized as the coreceptor for fibroblast growth factor-23 (FGF23) and a

167 se is CCL4, which binds and blocks CCR5, the coreceptor for HIV entry of HIV into new target cells.

168 Cas9 RNPs allowed ablation of CXCR4, a coreceptor for HIV entry.

169 Because CCR5 on Tregs serves as the coreceptor for human immunodeficiency virus (HIV) entry,

170 xpressed on multiple cell types and can be a coreceptor for human immunodeficiency virus 1.

171 t the CD8alphaalpha homodimer functions as a coreceptor for KIR3DL1, an inhibitory receptor of NK cel

172 results identify SorCS2 as an indispensable coreceptor for p75(NTR) and TrkB in hippocampal neurons

173 Nucleolin is an entry coreceptor for RSV(2) and also mediates the cellular ent

174 CD14, a coreceptor for several pattern recognition receptors and

175 CD14 is a coreceptor for several TLRs, including TLR4 and TLR2.

176 CD8alphabeta is a coreceptor for the T cell receptor (TCR) and binds to th

177 ion is the use of CXCR6 or other alternative coreceptors for entry, which may direct SIV toward CD4(+

178 rt that acidic lipids function with Ypt7p as coreceptors for HOPS, supporting membrane tethering and

179 agmVer entry in vitro and may serve as entry coreceptors for SIVagm in vivo, since their mRNAs were d

180 the Neogenin (NEO1) receptor and function as coreceptors for the bone morphogenetic protein (BMP)/gro

181 ycan motifs of gangliosides serve as initial coreceptors for these protein complexes, whereby a membr

182 nces were even more significant for usage of coreceptors FPRL1, CCR3 and APJ.

183 gnaling through promoting degradation of Wnt coreceptors Frizzled (FZD) and LRP6, and this activity i

184 receptor, and point to a broader paradigm of coreceptor function.

185 ficient blocking of Orco (olfactory receptor coreceptor) function.

186 n interaction that requires the nonsignaling coreceptor GDNF family receptor (GFRalpha3).

187 ch has been most notably applied to the CCR5 coreceptor gene, or the introduction of small mutations

188 arison, however, a functional homolog of the coreceptor Get2/CAML remained elusive.

189 he mechanoreceptor marker NF200 and the GDNF coreceptor GFRalpha1.

190 ps, via the Ret receptor tyrosine kinase and coreceptor Gfralpha1; Ret signaling up-regulates transcr

191 Binding and agonism are independent of a coreceptor glial cell line-derived neurotrophic factor f

192 fusion protein specific for both the CD4 and coreceptor gp120-binding sites.

193 fusion protein specific for both the CD4 and coreceptor gp120-binding sites.

194 ne morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar

195 domains of the IL-33 receptor (ST2) and its coreceptor, IL-1 receptor accessory protein, into a sing

196 promoting or repressive activity of a single coreceptor in multiple simultaneously active pathways.

197 TA form tight complexes with endogenous SERK coreceptors in the absence of ligand stimulus.

198 A striking feature of coreceptor-induced remission is the purging of T cells f

199 sults demonstrate that NF279 is a dual HIV-1 coreceptor inhibitor that interferes with the functional

200 er interfaces, areas remote from where these coreceptors interact, implying that inflammatory signali

201 The gp120-coreceptor interaction has previously been proposed as t

202 depends on Ca(2+) signaling triggered by Env-coreceptor interactions and involves the lipid scramblas

203 al compatibility and specificity of receptor-coreceptor interactions.

204 Finally, introducing the CD4 coreceptor into the hybridomas increased the proportion

205 o bind heparan sulfate proteoglycan and LRP4 coreceptors involved in the muscle-specific kinase signa

206 changes dependent on developmental stage and coreceptors involved.

207 er, the emergence of viruses using the CXCR4 coreceptor is a concern for therapies applying single-co

208 nteraction of the Lck kinase with CD4 or CD8 coreceptors is critical for generation of MHC specificit

209 IC EMBRYOGENESIS RECEPTOR-LIKE KINASE (SERK) coreceptor kinase.

210 ogether implicate SERK proteins as essential coreceptor kinases required for GSO1/SGN3 and GSO2 recep

211 of TCR signaling, suggesting that changes in coreceptor-Lck coupling constitute a mechanism for regul

212 Furthermore, the coreceptor-Lck coupling was independent of TCR activatio

213 Loss-of-function mutations in Wnt coreceptor LDL receptor-related protein 6 (LRP6) underli

214 lpha interacts with Wnt signaling at the Wnt coreceptor level.

215 ther coreceptors when tested at limiting CD4/coreceptor levels.

216 ncogenic Wnt signaling by binding to the Wnt coreceptor low-density lipoprotein receptor-related prot

217 (-/-) mice to determine contributions of Wnt coreceptor low-density lipoprotein receptor-related prot

218 y, we generated the conditional knockout Wnt coreceptor low-density lipoprotein receptor-related prot

219 We show that folding of the Wnt signaling coreceptor LRP6 is promoted by ubiquitination of a speci

220 pendent transcription without activating Wnt coreceptor LRP6 or beta-catenin.

221 that miR-19a negatively regulates FZD4, its coreceptor LRP6, and WNT signaling, and that antagonism

222 r 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS

223 We investigated whether this coreceptor-mimetic peptide improves the potency of broad

224 Here we investigated whether the coreceptor-mimetic peptide mim6 improved the potency of

225 ore potent than CD4-Ig due to its C-terminal coreceptor-mimetic peptide.

226 CD4-Ig is markedly increased by appending a coreceptor-mimetic sulfopeptide to its C terminus.

227 the potency of one class of bNAbs, show that coreceptor-mimetic sulfopeptides enhance neutralization

228 We identified two anti-HIV-1 antibodies, the coreceptor mimicking antibody 17b and the gp120-gp41 int

229 yo-EM structures of E51, a tyrosine-sulfated coreceptor-mimicking antibody, complexed with a CD4-boun

230 These coreceptors modulate T cell responses upon antigen prese

231 on, and zetazeta) and work in concert with a coreceptor module (either CD8 or CD4) to drive T cell ac

232 II-specific CD4(+) T cells, and 2) surrogate coreceptor modules enhance the function of these complex

233 minopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid.

234 receptors: VEGFRs (VEGFR1 and VEGFR2), their coreceptor neuropilin1 (NRP1), and platelet-derived grow

235 RCalphabeta-mediated recruitment of the MET coreceptor NRP1 and additional Rho-mediated activation o

236 s for the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular phenot

237 eptor accessory protein (IL1RAP; IL1R3) is a coreceptor of interleukin-1 receptor type 1 and has been

238 several antagonists of the odorant receptor coreceptor of the African malaria vector Anopheles gambi

239 It is an inhibitory coreceptor of the BCR and inhibits B cell activation.

240 tin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health a

241 otein receptor-related protein 6 (LRP6) is a coreceptor of the beta-catenin-dependent Wnt signaling p

242 Endoglin (ENG) is a coreceptor of the transforming growth factor-beta (TGFbe

243 ential role in HIV pathogenesis as the major coreceptor on CD4(+) T cells used by HIV, yet the functi

244 In vivo, the odorant receptor coreceptor (Orco) is an obligatory component for the fun

245 enes, and this inhibition depended on the JA coreceptor OsCOI1.

246 tivated receptor 4 (PAR4; Par4(-/-)), or its coreceptor, PAR3, were mated.

247 ing RNA (siRNA) suppresses activation of Wnt/coreceptor pathways.

248 We further show that the coreceptor PD-1 with its ligand PD-L1, immunotherapy tar

249 expressing alphabeta TCR but lacking CD4/CD8 coreceptors play protective as well as pathogenic roles.

250 SEMA3F acts on its coreceptors, plexins and neuropilins, among which neurop

251 at synergy emerges when Env engages multiple coreceptors prior to inducing fusion and when high-affin

252 The coreceptor probably functions by stabilizing and anchori

253 hereby the risk variant augments the BCR and coreceptor programs throughout B cell development, promo

254 B cell-activating factor receptor, and CD40 coreceptor programs, leading to broadly enhanced positiv

255 Evidence indicates that Abs binding to the coreceptors promotes T cell egress from these tissues.

256 f hae hsl2 suppressor mutations in the SERK1 coreceptor protein kinase gene.

257 ENESIS RECEPTOR-LIKE KINASE (SERK) family of coreceptor protein kinases, HAE and HSL2 are activated w

258 nd its interaction with CD44 (a putative MET coreceptor regulated by Wnt signaling and highly express

259 substrate), a receptor tyrosine kinase (RTK) coreceptor required for cellular migration, and pro-NRG1

260 g requires the interaction of GFRAL with the coreceptor RET.

261 rmline encoded TCR bias for MHC, and for the coreceptor sequestration model in the context of allorea

262 findings bring insights into the paradigm of coreceptor signaling, suggesting that, in addition to pr

263 early actin activity by hijacking chemokine coreceptor signaling, which activates a host dependency

264 D4 engagement appear to be restricted to the coreceptor site.

265 nhibitors suppresses binding at both CD4 and coreceptor sites on Env and triggers gp120 shedding, lea

266 Mice lacking the Lrp5 coreceptor specifically in osteoblasts and osteocytes ex

267 nteracts with the primary receptor CD4 and a coreceptor (such as chemokine receptor CCR5) to fuse vir

268 2 receptor Roundabout homolog 1 or the Slit2 coreceptor Syndecan-4.

269 heir interactions with the type III TGF-beta coreceptor (TbetaRIII) in live cells and their effects o

270 ernalize Tf-bound iron in the absence of the coreceptor TbpB.

271 receptor kinases (SERKs) are ligand-binding coreceptors that are able to combine with different liga

272 The present study examined how coreceptor therapy affects the migration of CD4(+) T cel

273 We reported that coreceptor therapy reverses diabetes in new onset NOD mi

274 f their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or

275 ellular receptor CD4 and a tyrosine-sulfated coreceptor to infect its target cells.

276 -associated minor H antigen, HA-1; (2) a CD8 coreceptor to promote function of the class I-restricted

277 engagement and signal transduction bring the coreceptor to viral particles at the cell surface, and c

278 sion level is low, the use of CXCR6 or other coreceptors to mediate infection may target SIV toward d

279 Previously, we found that a CCR5 coreceptor-tropic HIV-1 acquired a key HR1 or HR2 resist

280 Here, we report that a CXCR4 coreceptor-tropic HIV-1 selected the same key HR1 or HR2

281 Coreceptor tropism can be assessed by either phenotypic

282 The lack of selective factors, except for coreceptor tropism, is consistent with others' findings

283 vorable to its subsequent association with a coreceptor, typically CCR5 or CXCR4.

284 Lck is present either in coreceptor-bound or coreceptor-unbound (free) forms, and we here present evi

285 neuroimmune retention cues, Netrin-1 and its coreceptor UNC5B.

286 at the modest but significant differences in coreceptor usage efficiency, IFN-alpha sensitivity and v

287 Importantly, the levels of coreceptor usage efficiency, resistance to IFN-alpha and

288 likely different structural reasons for the coreceptor usage restriction and the different bnAb susc

289 pic predictions and phenotypic assessment of coreceptor usage.

290 ogous and heterologous plasma, and chemokine coreceptor usages for cell entry, suggesting similar abi

291 presenting different clades, tissue origins, coreceptor usages, and neutralization sensitivities.

292 Furthermore, we also show that coreceptor use is the determining factor for differentia

293 ed sabaeus AGM and found similar patterns of coreceptor use.

294 een viruses that use CXCR4 (X4) or CCR5 (R5) coreceptors, we generated viruses that are resistant to

295 XCR6 and CCR5 were more efficient than other coreceptors when tested at limiting CD4/coreceptor level

296 due to preexisting virus that uses the CXCR4 coreceptor, while true resistance occurs through viral a

297 CD5 is characterized as an inhibitory coreceptor with an important regulatory role during T ce

298 Ror can act as a Wnt coreceptor with frizzleds (fzs) in other contexts, so we

299 myeloid differentiation factor-2 (MD-2), the coreceptor within the TLR4/MD-2 receptor complex, as the

300 xpressed a T-cell receptor (TCR) and/or CD28-coreceptor without overrepresentation of specific TCR cl