ライフサイエンスコーパス: coregulator

1 firming a role for MKL1 as a transcriptional coregulator.

2 ce of dual coregulator functions of a master coregulator.

3 ll type-specific functions of this important coregulator.

4 ide synthesis pathways and a transcriptional coregulator.

5 he nucleus and function as a transcriptional coregulator.

6 ogenic mutations in a global transcriptional coregulator.

7 quences may also contain binding sites for a coregulator.

8 base damage, is an important transcriptional coregulator.

9 s in directing in vivo functions of a master coregulator.

10 derstood about its role as a transcriptional coregulator.

11 uding THAP11 and ZNF143, and transcriptional coregulators.

12 d3 transcription complexes by competing with coregulators.

13 formations that interact differentially with coregulators.

14 rough competition for their microRNA (miRNA) coregulators.

15 gulatory transcription factor GATA-1 and its coregulators.

16 and are involved globally as transcriptional coregulators.

17 nerships with other DNA-binding proteins and coregulators.

18 extended to understand other transcriptional coregulators.

19 ssion by recruiting diverese transcriptional coregulators.

20 ceptor (GR) is mediated by interactions with coregulators.

21 y, respond to a wide range of amino acids as coregulators.

22 ed with a restructuring of PPARalpha-binding coregulators.

23 ing (BET) proteins, which are established AR coregulators.

24 were initially described as transcriptional coregulators.

25 eacetylases (HDACs) are important epigenetic coregulators.

26 Src-1(-/-) mice to create mice deficient for coregulator action in all cell types.

27 timulatory input, and whose loss of negative coregulators additionally maintains their activated stat

28 sis, immunofluorescence, and high-throughput coregulator analysis, we show that bilirubin functions a

29 has been shown as a steroid hormone receptor coregulator and also as a crucial factor in DNA repair.

30 -1/steroid receptor coactivator-3, a nuclear coregulator and oncogene frequently amplified in human b

31 causes a loss of recruitment of critical AR coregulators and basal transcriptional machinery, includ

32 eins (CtBP1/2) are oncogenic transcriptional coregulators and dehydrogenases often overexpressed in m

33 tiple mechanisms, including pioneer factors, coregulators and epigenetic modifications have been iden

34 s review focuses on gene-specific actions of coregulators and evidence linking individual coregulator

35 in part by their differential utilization of coregulators and ligands.

36 tive, we retrace our steps into the field of coregulators and provide a summary of selected seminal w

37 ancer that affects ERalpha interactions with coregulators and shifts the DNA-binding signature of ERa

38 in turn produces differential recruitment of coregulators and subsequently different apoptotic effect

39 in part because of the multitude of TFs and coregulators and the diverse genomic space on which they

40 ittle is known about the identity of the key coregulators and the mechanisms by which they may potent

41 Second, coexpression of a set of 62 known NR coregulators and the six steroid receptors in 12 nonover

42 complexes containing transcription factors, coregulators, and additional non-DNA binding components.

43 microenvironment drivers including c-Myc, AR coregulators, and antiapoptosis factors Bcl-xl and Bcl2.

44 s of ERalpha expression, altered activity of coregulators, and cross-talk between the ERalpha and gro

45 hances breast cancer growth involving AR, AR coregulators, and downstream target genes.

46 e than 100 genes encoding nuclear receptors, coregulators, and their direct/indirect targets was stud

47 nscript HOTAIR is coordinated via ERs and ER coregulators, and this mechanism of HOTAIR overexpressio

48 Defining which transcription factor (TF) and coregulators are altered and combine to become oncogenic

49 udy was undertaken to identify which TFs and coregulators are commonly altered in PCa.

50 iple coregulators at all loci, or if certain coregulators are dedicated to specific loci is unknown.

51 The interactions between VDR and coregulators are essential for VDR-mediated transcriptio

52 These coregulators are frequently implicated in oncogenesis vi

53 The actions of transcriptional coregulators are highly gene-specific, that is, each cor

54 Transcriptional coregulators are important components of nuclear recepto

55 Chromatin coregulators are important factors in tumorigenesis and

56 RNA polymerase II transcription factors and coregulators are recruited to promoters and other regula

57 is-regulatory DNA sequences, transcriptional coregulators are required for the activation or suppress

58 ave confronted these challenges, positioning coregulators as tractable targets in the development of

59 omatin-associated factor and transcriptional coregulator, as a ligand-independent macrodomain-interac

60 e Trip-Br (SERTAD) family of transcriptional coregulators, as a molecule that is required for normal

61 urthermore, whether GATA-1 utilizes multiple coregulators at all loci, or if certain coregulators are

62 eractions with several transcription factors/coregulators at the promoter elements of various genes.

63 t binding of both, transcription factors and coregulators at the type 2 diabetes associated PPARG loc

64 Here we show that the transcriptional coregulator B cell leukemia/lymphoma 3 (Bcl3) limits gra

65 al impairment paralleled changes in receptor-coregulator binding interactions.

66 of resistance, we have developed a novel ER coregulator binding modulator, ERX-11.

67 Small molecule inhibition of VDR-coregulator binding represents an alternative method to

68 lecular network connecting the ligand to the coregulator binding surface.

69 losteric coupling between ligand binding and coregulator binding that determines receptor transcripti

70 receptor conformational changes that impact coregulator binding, transactivation and target gene exp

71 signals between dimer partners, ligands and coregulator-binding sites, thereby affecting signal tran

72 atory complexes that include both GR and the coregulator Brm, an ATPase subunit of the Swi/Snf chroma

73 Ser446 converts Bcl3 into a transcriptional coregulator by facilitating its recruitment to DNA.

74 lase 1 (LSD1) functions as a transcriptional coregulator by modulating histone methylation.

75 transcription resulting from recruitment of coregulators by the Nup98 repeat domain.

76 Overexpression of the transcriptional coregulators C-terminal binding proteins 1 and 2 (CtBP1

77 rement for expression, presumably additional coregulators can mediate GATA-1 function.

78 ification of both, transcription factors and coregulators, can profoundly improve understanding of me

79 rily conserved AAA ATPase ANCCA (AAA nuclear coregulator cancer-associated protein)/ATAD2 was identif

80 We have found that the transcriptional coregulator Cited2 regulates and refines two stages of C

81 Transcriptional coregulators (coactivators and corepressors) have emerge

82 ence suggests that there is a 'physiological coregulator code', which represents a fertile area for f

83 Instead, a set of stage-specific coregulators collaborates with master regulators and con

84 eam effector molecules, the nuclear receptor coregulators, compared with the full agonist dexamethaso

85 architectural factor HMGA1 and the Mediator coregulator complex cooperate to enhance basal transcrip

86 illustrate how fundamental the Pdx1:Swi/Snf coregulator complex is in the pancreas, and we discuss h

87 The Mediator is a conserved transcriptional coregulator complex required for eukaryotic gene express

88 ERG facilitates AR signaling by maintaining coregulator complexes at AR bound sites across the genom

89 Most coregulator complexes contain histone-modifying enzymes

90 is achieved by signal-dependent exchange of coregulator complexes that function to read, write, and

91 ssembly of multiprotein transcription factor-coregulator complexes.

92 ng our analyses of different transcriptional coregulator complexes.

93 d sequentially orchestrated exchange between coregulators (corepressors, coactivators).

94 ver, a detailed picture of the complexity of coregulators (CoRs) bound to a defined enhancer along wi

95 th PPARgamma affected the recruitment of the coregulators cyclic-AMP response element-binding protein

96 ationship exists between the transcriptional coregulator Daxx, SUMO, and PML nuclear bodies.

97 establish Ldb1 as a critical transcriptional coregulator during islet alpha-, beta-, and delta-cell d

98 We conclude that the coregulator effects of melanoma antigen-A11 on the AR NH

99 tion transcription assays that depend on the coregulator effects of melanoma antigen-A11.

100 Reliance on coregulators encoded by either the host or viral genome

101 cally altered recruitment of transcriptional coregulator factors by SoxE proteins, displacing coactiv

102 The GATA1 coregulators FOG1 and TAL1 dissociate from mitotic chrom

103 DD4/5 is required for the recruitment of the coregulators FOG1 and the nucleosome remodeling and deac

104 selected the CThPN-specific transcriptional coregulator Fog2 for functional analysis.

105 as a positive and a negative transcriptional coregulator for discrete subsets of genes that are regul

106 Thus, G9a has a dual and selective role as a coregulator for ERalpha target genes.

107 cogene AIB1/ACTR/SRC-3 and a transcriptional coregulator for estrogen and androgen receptors and is s

108 In addition to the crucial GATA-1 coregulator Friend of GATA-1 (FOG-1), a component of the

109 n by the transcription factor GATA-1 and its coregulator Friend of GATA-1 (FOG-1).

110 ukemogenesis, which often functions with the coregulator Friend of GATA-1 (FOG-1).

111 1 regulates target genes with or without the coregulator Friend of GATA-1 (FOG-1).

112 ctivation only at target genes requiring the coregulator Friend of GATA-1 (FOG-1).

113 We conclude that the coregulator function of MAGE-11 extends to isoform-speci

114 spective to the molecular governance of dual coregulator functions of a master coregulator.

115 iltering identified commonly altered TFs and coregulator genes, including well-established (e.g. ERG)

116 Deregulated expression of coregulators has been implicated in diverse disease stat

117 e first authentic coregulator, more than 400 coregulators have been identified and characterized, and

118 ssociate physically with the transcriptional coregulator HCF-1 (host cell factor 1) and recruit HCF-1

119 teins and proteolysis of the transcriptional coregulator HCF-1.

120 of ES cells, binds with its transcriptional coregulator, Hcf-1, to a highly conserved enhancer eleme

121 issense mutation in a global transcriptional coregulator, HCFC1, was identified in the index case.

122 domain, but Lin11, Isl-1, Mec-3 (LIM) domain coregulator Hic-5 (TGFB1I1) binds to the relatively unch

123 we examined recruitment of nuclear receptor coregulators, histone modifications and RNA polymerase I

124 roteolytic maturation of the transcriptional coregulator Host cell factor 1 (HCF1).

125 Promoter binding by IR was mediated by coregulator host cell factor-1 (HCF-1) and transcription

126 ion of MYC with the abundant transcriptional coregulator host cell factor-1 (HCF-1).

127 The coregulator hydrogen peroxide-inducible clone 5 (Hic-5)

128 Among the many coregulators identified were all of the subunits of the

129 Several key transcription factors and coregulators important to peripheral nerve myelination h

130 is clinically significant yet underexplored coregulator in aggressive early stage PCa.

131 oma protein), functions as a transcriptional coregulator in many fundamental cellular processes.

132 abundance, primate-specific steroid receptor coregulator in normal tissues of the human reproductive

133 lysis suggested that addition of the nuclear coregulators in a multivariable analysis with ER and E2

134 strate an approach to identify cancer-driver coregulators in cancer, and that PGC1alpha expression is

135 ssion and activity of androgen receptor (AR) coregulators in prostate cancer is an important mechanis

136 role of specific nuclear receptors and their coregulators in the dynamic control of mitochondrial bio

137 ic combinations of transcription factors and coregulators in the fine tuning of organismal metabolism

138 revious observations that it weakly recruits coregulators in vitro.

139 ects by recruiting and dissociating specific coregulators in WAT, driving the expression of PPARalpha

140 s-associated protein 1 (MTA1), a dual master coregulator, in epithelial cells, and that MTA1 status i

141 ion of Zfp521, a zinc finger transcriptional coregulator, in prehypertrophic chondrocytes.

142 R-mediated gene regulation is enhanced by AR coregulators, inactivation of those coregulators is emer

143 However, challenges in targeting coregulators include identifying evidence of cancer-spec

144 These coregulators include the cell-type-specific multi-zinc f

145 en stimulation, ERalpha recruits a number of coregulators, including both coactivators and corepresso

146 TR-FRET-based competitive ligand binding and coregulator interaction assays to screen 2693 compounds

147 tein via interruption of the AR-AR selective coregulator interaction.

148 D2 also disrupts androgen receptor-coregulator interactions in ex vivo cultures of primary

149 Thus, coregulator interactions of Pu.1 were examined by immuno

150 de evidence that targeting androgen receptor-coregulator interactions using peptidomimetics may be a

151 monstrate the unexpectedly dynamic nature of coregulator interactions within enhancer complexes, whic

152 on and activation as well as the dynamics of coregulator interactions within the enhancer complex.

153 RIP140 is a transcriptional coregulator involved in energy homeostasis, ovulation, a

154 tors are highly gene-specific, that is, each coregulator is required only for a subset of the genes r

155 ed by AR coregulators, inactivation of those coregulators is emerging as a promising therapy for pros

156 s, the glucocorticoid receptor (GR), and its coregulators is poorly understood.

157 nce of interactions between GATA-1 and other coregulators is poorly understood.

158 e of combinational PTM codes on histones and coregulators is profoundly shaped by regulatory interpla

159 One such group of ubiquitously expressed coregulators is the metastasis-associated protein (MTA)

160 ator 15 (MDT-15 or MED15), a transcriptional coregulator, is essential for low-temperature-induced lo

161 us, while Med1 is a context-dependent GATA-1 coregulator, it also exerts specialized functions in ery

162 -2 or SRC-3, we hypothesized that permissive coregulator levels comprise a necessary adipogenic equil

163 The widely expressed transcriptional coregulator, ligand-dependent corepressor (LCoR), initia

164 We propose a coregulator matrix model in which distinct combinations

165 nt nuclear receptors at different domains by coregulator may lead to differential receptor transactiv

166 CoR and HDACs, indicating that this class of coregulators may play a previously unrecognized role dur

167 (CITED2), a mechanosensitive transcriptional coregulator, mediates this chondroprotective effect of m

168 GATA-1 corepressor expands the repertoire of coregulators mediating establishment/maintenance of the

169 ich is the primate-specific steroid receptor coregulator melanoma antigen-A11 (MAGE-A11).

170 The MTA1 coregulator (metastatic tumor antigen 1), a component of

171 corepressors (COR; n = 599); mixed function coregulators (MIXED; n = 511), and to address the challe

172 r coactivator-1 (SRC-1), the first authentic coregulator, more than 400 coregulators have been identi

173 the recently established role for the master coregulator MTA1 and MTA1-containing nuclear remodeling

174 ically interacts with bodies enriched in the coregulator NCoA-2, DNA-dependent foci and chromatin tar

175 identified component of the transcriptional coregulator network, was found to interact with the Nucl

176 n AR and SLIRP and that SLIRP functions as a coregulator of AR with properties of a corepressor in a

177 nature in CRPC, including HOXB13, a critical coregulator of AR-V7 function.

178 transcription and acts as a transcriptional coregulator of cJun.

179 Lipin 1 is a coregulator of DNA-bound transcription factors and a pho

180 identified Tip60 as the first dual-function coregulator of ERbeta1.

181 uman hepatoma cells and identified AMPK as a coregulator of FXR.

182 zation and acts as a nuclear transcriptional coregulator of gene expression.

183 These observations establish PML as a coregulator of IFN-gamma-induced MHC class II expression

184 These results demonstrate that FUS is a coregulator of MITF activity and provide new insights in

185 ng noncoding RNA, LincRNA-Tnfaip3, acts as a coregulator of NF-kappaB to modulate inflammatory gene t

186 PGC1alpha is a key transcriptional coregulator of oxidative metabolism and thermogenesis.

187 protein Bcl3 is primarily a transcriptional coregulator of p52 and p50 homodimers.

188 , this work identifies CHD4 as an epigenetic coregulator of PAX3-FOXO1 activity, providing rational e

189 pendent chromatin remodeler, acts as crucial coregulator of PAX3-FOXO1 activity.

190 uced signaling pathway and a transcriptional coregulator of several TGF-beta1 profibrotic response ge

191 38 MAP kinase (p38K)/Mef2/MnSOD pathway is a coregulator of stress and life span.

192 icating that ASCL1 is a member and LMO1 is a coregulator of the ADRN neuroblastoma CRC.

193 Thus, p300 is the dominant coregulator of the CBP/p300 pair for androgen-regulated

194 that TET2 protein is a cofactor of EBNA2 and coregulator of the EBV type III latency program and DNA

195 icate that HO-1 plays an important role as a coregulator of the erythroid differentiation process.

196 tor-gamma coactivator-1alpha (PGC-1alpha), a coregulator of the GCs receptor (GR), and that the overe

197 We propose that C2CD4A is a transcriptional coregulator of the glycolytic pathway whose dysfunction

198 teracting protein (GRIP)1, a transcriptional coregulator of the p160 family, which is recruited to th

199 The histone acetyltransferase TIP60 is a coregulator of transcription factors and is implicated i

200 Lhx6 and -8 act as transcription factors and coregulators of cell lineage specification.

201 hether other cell surface molecules serve as coregulators of EMS1.

202 and -beta serve as inducible transcriptional coregulators of genes involved in mitochondrial biogenes

203 ormone receptors; NCoR2) are well-recognized coregulators of nuclear receptor (NR) action.

204 ry biomarker C-reactive protein as prominent coregulators of the observed annual pulse increases.

205 e pathways, but little is known about direct coregulators of this protein.

206 es and the tight packing of multiple TFs and coregulators on stretches of regulatory DNA.

207 Estrogen receptor (ER) coregulator overexpression promotes carcinogenesis and/o

208 damage response protein and transcriptional coregulator PARP-1.

209 omeobox transcription factor as a key BRD4-S coregulator, particularly in triple-negative breast canc

210 ers, demonstrated that the estrogen receptor coregulator PELP1 is a proto-oncogene.

211 ERalpha-coregulator peptide binding in vitro and RIME (rapid imm

212 r, nuclear receptor coactivator-2 (Tif2), in coregulator peptide recruitment assays.

213 ciation of both PPARbeta/delta and PPARgamma coregulator peptides in response to ligand activation, c

214 complex that was devoid of ERRgamma and the coregulator peroxisome proliferator-activated receptor g

215 posure through activation of the thermogenic coregulator PRDM16.

216 rough the progesterone receptor (PR) and its coregulators prepares the human endometrium for receptiv

217 ismal body weight by reshaping the PPARalpha coregulator profile, remodeling WAT to improve metabolic

218 Here we report our study of endogenous human coregulator protein complex networks obtained from integ

219 Rgamma modulator characteristics by inducing coregulator protein interactions, PPARgamma-dependent ex

220 e "open" chromatin compartment together with coregulator proteins essential for regulation of gene ex

221 Coregulator proteins play key roles in transcriptional c

222 involving LXXLL motifs in androgen receptor-coregulator proteins such as PELP1 using a novel, small

223 tory elements of target genes and recruiting coregulator proteins to remodel chromatin and regulate t

224 ar receptors that function coordinately with coregulator proteins.

225 ing, via interaction with critical oncogenic coregulator proteins.

226 of DNA-bound functional dimers positions the coregulators proteins.

227 pose energy homeostasis via these metabolism coregulators, provides a potential therapeutic strategy

228 ; the response regulator RcsB; the accessory coregulator RcsA; and an outer membrane bound lipoprotei

229 als transduced across the ligand binding and coregulator recruitment by all three ERR subtypes, which

230 -binding surface, consistent with an altered coregulator recruitment profile.

231 uncover coupling between ligand binding and coregulator recruitment that affects the potency rather

232 Additional studies of coregulator recruitment using ChIP-chip analysis reveale

233 -fold vs. E2) is enhanced at several levels (coregulator recruitment, chromatin binding); nevertheles

234 ates intramolecular signalling important for coregulator recruitment, consistent with previous observ

235 we show that MAGE-11 is an isoform-specific coregulator responsible for the greater transcriptional

236 Quantitative proteomics also found the coregulator RING1 and YY1 binding protein (RYBP) whose m

237 ere, we demonstrate that the transcriptional coregulator RIP140 regulates intestinal homeostasis and

238 ific requirements for the presumed "general" coregulators Sin3a and Sin3b in islet beta-cells, with S

239 These coregulator-specific gene subsets often represent select

240 PXR and RXRalpha bind to the transcriptional coregulator SRC-1 with higher affinity when they are par

241 rogen receptors ERalpha and ERbeta, with key coregulators (SRC3 and RIP140) and chromatin binding sit

242 is recruited to ERalpha by steroid receptor coregulators (SRCs) for enhancer maturation and maintena

243 pregulation of the oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also

244 3 (SIRT3) by androgen receptor (AR) and its coregulator steroid receptor coactivator-2 (SRC-2) enhan

245 ational modifications (PTMs) on histones and coregulators such as corepressors, coactivators, DNA-bin

246 trogen receptors (ERs) along with various ER coregulators such as histone methylases MLL1 (mixed line

247 eded for the efficient recruitment of GR and coregulators such as Mediator to chromatin.

248 Estrogen receptors (ERs) and ER coregulators such as mixed lineage leukemia (MLL) histon

249 DC-specific transcript (DC-SCRIPT) as an NR coregulator, suppressing type I steroid NRs estrogen rec

250 essful transition between these two phases ("coregulator switching") is required for proper enhancer

251 Thus, Hic-5 is a versatile coregulator that acts by multiple gene-specific mechanis

252 g protein 140 (RIP140) is a nuclear receptor coregulator that affects a wide spectrum of biological p

253 vator-1alpha (PGC-1alpha), a transcriptional coregulator that binds to numerous transcription factors

254 c demethylase 1 (KDM1A) is a transcriptional coregulator that can function in both the activation and

255 erosum SELF-PRUNING 6A), a FLOWERING LOCUS T coregulator that functions as a signal for tuberization.

256 ene protein-A11 (MAGE-11) is an AR selective coregulator that increases AR transcriptional activity.

257 ing to melanoma antigen-A11 (MAGE-11), an AR coregulator that is also primate-specific.

258 cells and acts as an ERalpha transcriptional coregulator that is recruited by 17beta-estradiol to the

259 eucine rich protein 1) is a nuclear receptor coregulator that is upregulated during breast cancer pro

260 eucine-rich protein 1) is a nuclear receptor coregulator that plays an important role in ER signaling

261 RERE is a widely-expressed nuclear receptor coregulator that positively regulates retinoic acid sign

262 y protein 4 (LMO4) is a transcription factor coregulator that promotes the assembly of multiprotein c

263 ivator activator (CoAA) is a dual-functional coregulator that regulates steroid receptor-mediated tra

264 CgrC proteins of Pseudomonas aeruginosa are coregulators that are required for the phase-variable ex

265 ases and a host of transcription factors and coregulators that control their activity during transcri

266 3a and Sin3b) are paralogous transcriptional coregulators that direct cellular differentiation, survi

267 foundation of our knowledge for the now 350+ coregulators that have been identified to date.

268 Ldb1 and Ldb2 are coregulators that mediate Lin11-Isl1-Mec3 (LIM)-homeodom

269 roid receptor RNA activator (SRA) binding NR coregulators that target steroid-responsive promoters an

270 on can alter the selective binding of TFs to coregulators, that prior binding events can lead to sele

271 While FOG-1 is an established GATA-1 coregulator, the importance of interactions between GATA

272 el of metastasis-associated protein 1 (MTA1) coregulator, the physiological role of the MTA1 coactiva

273 proteomic technique, we identified a new AR coregulator, the transcription factor Grainyhead-like 2

274 e activity of transcriptional regulators and coregulators, there are few examples of core components

275 o the DAD limits HDAC3 interaction with this coregulator, thereby facilitating SMRT coactivation of p

276 Furthermore, inhibition of chromatin coregulators through interference with key inflammatory

277 tor of hematopoiesis GATA-1 recruits diverse coregulators to chromatin, which mediate transcriptional

278 ational changes that recruit transcriptional coregulators to promoter elements.

279 CSL interacts with coregulators to repress and activate transcription from

280 lar to planar E(2) The TPE compounds recruit coregulators to the ER differentially and predictably, l

281 optosis regulator 1 (CCAR1), a transcription coregulator, to the PPARgamma gene GBRs.

282 his screen was directed against a variety of coregulators, transcription modifiers, signaling molecul

283 Here we demonstrate that the transcriptional coregulator transducin-like enhancer of split 3 (TLE3) i

284 liver fluke Opisthorchis viverrini and this coregulator using both an Mta1(-/-) mouse model of infec

285 Thus, GR restricts actions of its own coregulator via CDK9-mediated phosphorylation to a subse

286 on of MTA1 (metastasis-associated protein 1) coregulator via NF-kappaB signaling in hepatic cells.

287 Regulating the activity of a coregulator via post-translational modifications would t

288 GR recruits many coregulators via the well-characterized AF2 interaction

289 Recruitment of these coregulators was likely responsible for the increase in

290 y in eukaryotic transcription is provided by coregulators, which are recruited by DNA-binding factors

291 Here, we show that p27 is a cJun coregulator, whose assembly and chromatin association is

292 summary, this study has identified a new AR coregulator with a multifaceted role in prostate cancer,

293 een the roles for BRCA1 as a transcriptional coregulator with control of its expression via an autore

294 d blocks the interaction between a subset of coregulators with both native and mutant forms of ER.

295 coregulators and evidence linking individual coregulators with specific physiological pathways.

296 riptional activity of AR is modulated by the coregulators with which it interacts, and consequently d

297 ecific master regulators and transcriptional coregulators within developmental stage-specific enhance

298 tream substrates such as the transcriptional coregulator YAP1.

299 cell factor 1 (Ebf1) and the transcriptional coregulator Zfp521 as components of the machinery that r

300 inc finger unit found in the transcriptional coregulator ZNF217 recognizes DNA but with an affinity a