ライフサイエンスコーパス: cornea

1 ld sores) and keratitis (inflammation of the cornea).

2 laced in the posterior chamber away from the cornea.

3 s such as decalcified ivory, fish scales, or cornea.

4 d maps of TCT and En/DMT of the central 6-mm cornea.

5 e with properties most similar to the native cornea.

6 on-invasive means of delivering siRNA to the cornea.

7 ickness (TCT) and En-DMT of the central 6-mm cornea.

8 ll deficiency (LSCD) were noted on the right cornea.

9 and the recruitment of mural cells into the cornea.

10 discriminate structural changes in a damaged cornea.

11 emination of virus to, and infection of, the cornea.

12 a resolution steepened the central posterior cornea.

13 events can lead to blinding scarring of the cornea.

14 mportant role in the pathogenicity of the KC cornea.

15 timulatory molecule CD80 but not CD86 in the cornea.

16 d in compound eyes incorporating a chitinous cornea.

17 ection, but also along the depth axis of the cornea.

18 eovascularization in the central 5 mm of the cornea.

19 therapy as a means of safely stiffening the cornea.

20 r in en face maps covering almost the entire cornea.

21 of the non-linear mechanical behavior of the cornea.

22 signaling in response to inflammation in the cornea.

23 e cellular and molecular organization of the cornea.

24 lpful in cases of iris defects and irregular corneas.

25 atoconus, subclinical keratoconus and normal corneas.

26 bit skin cells and in vivo in infected mouse corneas.

27 ratocytes both in culture and within ex vivo corneas.

28 nt iNKT cell subset in infected asymptomatic corneas.

29 ion in vitro and ex vivo in cultured porcine corneas.

30 had better DOF curves and DCNVA than normal corneas.

31 epithelial cells, respectively, in infected corneas.

32 requency shift of 4 MHz per decade in normal corneas.

33 but increased the opacity in HSV-1-infected corneas.

34 duced the development of hypoxia in infected corneas.

35 on the injury response in Mmp12(-/-) and WT corneas.

36 sted for differentiating normal from ectatic corneas.

37 ed in Mmp12(-/-) corneas as compared with WT corneas.

38 aired WST-D/NIR treated and untreated rabbit corneas.

39 erapy for stiffening pathologically weakened corneas.

40 ed area without the need for cadeveric donor corneas.

41 ated wolframin expression in human and mouse corneas.

42 come the global shortage of transplant-grade corneas.

43 ent diameters around the central part of the cornea (1, 2, and 3 mm) and reading elevation values at

44 randomized preclinical trial with 24 paired corneas, 1 was stored in OC and the other in ASM, using

45 s from 205 patients distributed in 82 normal corneas, 40 early-stage keratoconus and 83 established k

46 ift at the thinnest point compared to normal corneas (5.7072 +/- 0.0214 vs 5.7236 +/- 0.0146 GHz, P <

47 Three sets of paired human donor corneas, 5 pairs each, were stored in organ culture medi

48 nerves in response to inflammation using the cornea, a normally avascular and densely innervated ocul

49 Haze occupied the central cornea, accompanied by corneal edema and neovascularizat

50 icant association with willingness to donate cornea after death (p < 0.05, (x)(2) = 12.187).

51 protocol therapy and had stable, noninflamed corneas after 16 weeks.

52 67.3% were willing to donate their corneas after death.

53 iate analysis suggested that a younger donor cornea age and higher donor endothelial cell count are a

54 and visual field mean deviation, and thinner corneas (all P < 0.001).

55 The central region of the cornea, an important area for visual function in dry eye

56 ornea by 60 min and 0.0002% penetrated human cornea and 0.001% penetrated human sclera.

57 rited disorders that affect any layer of the cornea and are usually progressive, bilateral conditions

58 ial stem cells (SC) reside in limbus between cornea and conjunctiva.

59 blue, which should not penetrate the intact cornea and did not do so in our model.

60 and pro-inflammatory factors in the grafted cornea and draining lymph nodes (dLNs) were evaluated wi

61 p, with the most frequent in glaucoma (24%), cornea and external diseases (22%), and neuroophthalmolo

62 the dynamic biomechanical properties of the cornea and have been shown to be biomarkers of corneal d

63 h dextran (WST-D) to the epithelium-debrided cornea and illumination with Near Infrared (NIR), has be

64 nea (first, through the central point of the cornea and keratoconus apex; second, as the perpendicula

65 lamp biomicroscopy was used to evaluate the cornea and lens, and retinal vasculature was examined by

66 ing debridement of different portions of the cornea and limbus and applied them to the dual-fluoresce

67 Thin cornea and low CH are main risk factors.

68 Masking and Randomization: Two masked cornea and refractive surgeons of different training bac

69 vivo model using discs of porcine and human cornea and sclera (5 mm diameter) to assess penetration

70 Cornea and sclera homogenates possessed a measurable amo

71 ductase, a nitrate and nitrite reductase, in cornea and sclera.

72 y eyelids, eyelid edema, highly vascularized cornea and tarsal plates (TPs), slit eye, and increased

73 ed gK, UL20, ICP0, and gB transcripts in the cornea and TG compared to levels in control mice.

74 +), and NK1.1(+) T cells was observed in the cornea and TG of SPP-inducible knockout mice compared to

75 ion that stem cells exist within the central cornea and that their progeny have the capacity to migra

76 CD8(+) T(RM) cells that infiltrated both the cornea and the TG.

77 ent antiviral CD8(+) T(RM) cells in both the cornea and the trigeminal ganglia (TG).

78 SPP mRNA was reduced by more than 93% in the cornea and trigeminal ganglia (TG) and by 99% in the liv

79 ly rejecting grafts compared to both healthy corneas and clear grafts (P < .001).

80 identified along the posterior margin of the corneas and DSAEK buttons in all cases.

81 ients may be falsely high because of clouded corneas and increased corneal rigidity.

82 ior and posterior stroma in healed WST-D/NIR corneas and untreated controls revealed no obvious diffe

83 f genetically marked cells in organ-cultured corneas and via computational modeling.

84 middle layer, and the full thickness of the cornea), and the 10 mm zone corneal volume.

85 s, displacement of the thinnest point of the cornea, and the presence of posterior surface depression

86 of the iris is subject to refraction by the cornea, and thus an outside observer sees a virtual imag

87 genic levels of VEGF-A within HSV-1-infected corneas, and CD4(+) cell depletion promoted reinnervatio

88 ent of neutrophils infiltrating the infected corneas, and the depletion of neutrophils reduced the de

89 ssociated glycolytic genes in HSV-1 infected corneas, and the outcome of blocking hypoxia-inducible f

90 Paired cornea- and BM-derived myofibroblast specimens from each

91 concentrations of the cytokine VEGF-A in the cornea are associated with HSK severity.

92 The lens and central cornea are avascular.

93 of the cornea has been found and keratoconus corneas are statistically significantly different from n

94 and lower CCT, suggestive of thin and stiff corneas, are at greater risk of progression.

95 kade was significantly reduced in Mmp12(-/-) corneas as compared with WT corneas.

96 We recommend classifying FECD corneas as having clinically definite edema (based on sl

97 Experiments in ex vivo porcine cornea at different intraocular pressures reveal that Re

98 fail, consistent with non-linear changes in cornea at high IOP.

99 potential recipients and the number of donor corneas available.

100 y measuring mechanical properties of porcine corneas based on volumetric deformation following varyin

101 Thus the Ace2(-/-) cornea, because of easy accessibility, may provide an at

102 stically significantly different from normal corneas, but for precise differentiating of keratoconus

103 lacrimal drainage) 0.071% penetrated porcine cornea by 60 min and 0.0002% penetrated human cornea and

104 timulated microenvironment remodeling in the cornea by promoting the paracrine action of secreted int

105 parallel with a partial reinnervation of the cornea by TRPM8(+) fibers and with an increase in basal

106 e mice with fungal infection and the control corneas by real-time PCR.

107 Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding immunoinflammatory condit

108 an sulfate epitopes were majorly observed in cornea, cartilage and brain; and mainly involved in embr

109 ogenesis of an immunoblinding disease of the cornea caused by HSV type 1 infection.

110 s of HSV-1-infected WT mice, the symptomatic corneas CD1d KO mice, with iNKT cell deficiency, had inc

111 Seven of 16 (43.7%) eyes with N-PCG had a cornea clear enough at presentation for a goniotomy comp

112 nting with microbial keratitis at a referral cornea clinic in South India.

113 In the eye cornea, comparatively low mechanical forces are detected

114 erence in the virus titer recovered from the cornea comparing vaccinated mice, HSV-1 0DeltaNLS-vaccin

115 ann- correlated intraocular pressure (IOPg), cornea-compensated IOP (IOPcc) using the ORA, and centra

116 d FECD (FECD group) and patients with normal cornea (control group) were enrolled.

117 ve, and postoperative patient data and donor cornea data.

118 In response to cornea debridement wounding, we find increased expressio

119 subclinical edema (n = 16), in <=42% of FECD corneas deemed not to have edema (n = 62), and in <=5% o

120 CD) drops, the HCEC may decompensate to keep cornea dehydration which leads to corneal edema.

121 Paired cornea-derived and BM-derived alpha-SMA+ myofibroblast p

122 ACE2-deficient mice showed normal appearing corneas, devoid of haze.

123 The spherical aberration for 8.0 mm cornea diameter showed the highest correlations with the

124 nclude that the cells that develop the mouse cornea do not require a primary stroma for cell migratio

125 n collagen fibers are present in the wounded cornea during the early phases of wound healing.

126 y and reproducibility in normal and diseased cornea eyes through all map zones.

127 corneal surgeon (JMG) and 6 novice surgeons (cornea fellows under supervision) were reviewed.

128 f physician and 57 cases were performed by 6 cornea fellows.

129 by projecting two perpendicular axes onto a cornea (first, through the central point of the cornea a

130 oscopy, we investigated the developing mouse cornea, focusing on the invading cells, the extracellula

131 nced salt solution) to the de-epithelialized cornea for 30 minutes, followed by irradiation with a 6

132 l layer more pronounced in the center of the cornea for all postoperative timepoints.

133 mically or photochemically cross-linking the cornea for therapy presents a unique approach to managin

134 Corneas from aged knockin mice exhibit signs of opacific

135 y it has placed a burden on the provision of corneas from cadaveric donors.

136 ose of this study was to investigate whether corneas from donors >=80 years old are suitable for Desc

137 The use of corneas from donors aged >=80 for DMEK surgery may there

138 els of HSV-1 gene expression were similar in corneas from HSV-CD80-infected and parental virus-infect

139 ed a useful model for differentiating normal corneas from the clinically normal eyes of patients with

140 The corneas from the two groups showed a non-linear mechanic

141 on (AMD), diabetic retinopathy, glaucoma, or cornea guttata (aOR, 1.35; P = 0.006); use of Trypan blu

142 aucoma, Sicca syndrome, epiretinal membrane, cornea guttata, or amblyopia.

143 Unlike the well-studied chick, the mouse cornea had no acellular primary stroma.

144 t impact on optic neuropathy, dose to 20% of cornea had the largest impact on neovascular glaucoma, a

145 Hyperprolate corneas had better DOF curves and DCNVA than normal corn

146 Our results suggest that porcine cornea has a higher relative suitability for corneal tra

147 ns of corneal leukocytes (CLs) in the normal cornea has been firmly established.

148 An age-dependent stiffening of the cornea has been found and keratoconus corneas are statis

149 The cornea has the densest sensory innervation of the body,

150 , that the outer edge (limbus) of live human corneas has a substantially lower bulk modulus compared

151 Keratoconus corneas have a significantly reduced Brillouin frequency

152 Stromal cells were cultured from human corneas (HCSC) and mouse corneas (MCSC).

153 geometric and volumetric characterization of cornea in pediatric patients with early and mild KC usin

154 more frequently located at the centre of the cornea in the glaucoma group (P = 0.039).

155 first measurement of shear modulus in human corneas in vivo using optical coherence elastography (OC

156 be the non-linear mechanical behavior of the cornea, in order to characterize the capability of the n

157 ging therapies to replace the need for donor corneas include pre-formed biosynthetic buttons and in s

158 ldehyde pathway, which dominates in skin and cornea, incorporate histidine residues.

159 is an immune response to the lens following cornea injury involving the lens-associated MAGP1-rich c

160 The cornea is a normally transparent tissue necessary for vi

161 rneal nociceptors.SIGNIFICANCE STATEMENT The cornea is a richly innervated and highly sensitive tissu

162 The cornea is extensively innervated by trigeminal ganglion

163 esent in many tissues but information on the cornea is lacking.

164 As the cornea is one of the most transplanted tissues in the bo

165 As a protective mechanism, the cornea is sensitive to noxious stimuli.

166 domly selected from 312 patients with normal corneas; Keratoconus group, including 1 eye randomly sel

167 topically to mice eyes penetrated across all cornea layers and resulted in a significant reduction of

168 Still, topical modulation of Piezo2 in the cornea may be useful to selectively relief unpleasant se

169 cultured from human corneas (HCSC) and mouse corneas (MCSC).

170 We show that the cornea must be described by at least two shear moduli, c

171 In the cornea, myofibroblasts are derived primarily from stroma

172 o have edema (n = 62), and in <=5% of normal corneas (n = 74).

173 rol (non-treated) and NaOH-treated (damaged) corneas (n = 8).

174 As the outer lens in the eye, the cornea needs to be strong and transparent.

175 The basic principles of cornea nerve patterning have been established many years

176 both as a function of IOP in ex vivo porcine cornea, obtaining values consistent with both tensile an

177 stem cells of non-skin origin (e.g. that of cornea, oesophagus, vagina, bladder, prostate) that expr

178 nd circular actin fibers associated with the corneas of A. irradians that may represent muscles whose

179 the predominant iNKT cell subset in infected corneas of asymptomatic B6 mice (with little to no corne

180 Scarred corneas of both normal and abnormal shape are independen

181 s of wild-type (WT) B6 mice, the symptomatic corneas of CD1d KO mice, which lack iNKT cells, showed (

182 Moreover, corneas of galectin-3-deficient mice failed to stimulate

183 Moreover, compared to the asymptomatic corneas of HSV-1-infected WT mice, the symptomatic corne

184 e number of CD4(+) T cells was lower, in the corneas of HSV-CD80-infected mice than in mice infected

185 blotting, PPARalpha was downregulated in the corneas of humans with diabetes and diabetic rats.

186 nalysis detected 75 known HSV-1 genes in the corneas of mice infected with HSV-CD80 or parental virus

187 to no corneal herpetic disease), compared to corneas of symptomatic mice (with severe corneal herpeti

188 a), TNFalpha, and TLR4 were evaluated in the corneas of the mice with fungal infection and the contro

189 antification of IL-1beta and TNFalpha in the corneas of the mice with fungal infection was determined

190 s has implications for the proposed calcitic corneas of trilobites, which we posit are artefacts of p

191 xt generation RNA sequencing from individual corneas of two distinct patient populations - one from t

192 Moreover, compared to asymptomatic corneas of wild-type (WT) B6 mice, the symptomatic corne

193 and anterior stroma were generated in chick corneas on embryonic day 7.

194 CI, 5.2-6.6; P < 0.001), and thinner central cornea (OR, 1.2; 95% CI, 1.03-1.5; P = 0.013).

195 y male with fellowship training in glaucoma, cornea, or neuro-ophthalmology.

196 dds ratio [OR], 1.44; P = 0.037; and smaller cornea: OR, 3.95; P = 0.045).

197 ounger age: OR, 1.36; P = 0.023; and smaller cornea: OR, 4.78; P = 0.057).

198 oocyte), tissues (Xenopus epithelium and rat cornea), organs (Xenopus gills and mouse skin) and appen

199 virus, but multiple factors are involved in cornea pathology in response to ocular virus challenge.

200 ed in vaccinated mice challenged with HSV-1, cornea pathology was mixed with a reduction in neovascul

201 oducibility were similar in all subgroups of cornea patients, excluding the DES group, for which repr

202 rmation about the biomechanical state of the cornea perpendicular to the surface.

203 e Ace2 gene (Ace2(-/-) ), developed a cloudy cornea phenotype as they aged.

204 sruption of the basement membrane in wounded corneas prompted an increase in the abundance of IL-1bet

205 The cornea provides the largest refractive power for the hum

206 FECD eyes with an oblate posterior cornea (Q value >0) had a 3.0 times higher risk of hyper

207 P = .011), compared to spherical or prolate corneas (Q value <= 0).

208 llagen organization of the wounded embryonic cornea recapitulate the native macrostructure.

209 nprecedented endothelial cell quality: no OC corneas remained suitable for transplantation, but one-t

210 In vitro, VEGF-A from infected corneas repressed sensory nerve growth and promoted symp

211 t early during ocular herpesvirus infection, cornea-resident IFN-gamma-producing PLZF(lo)RORgammat(lo

212 is study, we examined the protective role of cornea-resident iNKT cell subsets using the mouse model

213 Debridement of the whole cornea resulted in significant hemangiogenesis (HA) and

214 HSV-1) keratitis, we found that infection of corneas resulted in subsequent infection of ocular gland

215 can occur during microbial infection of the cornea, resulting in potentially permanent visual defici

216 transmission electron tomography on four KC corneas showed the degeneration of microfibrils within t

217 higher SP-A1 and thinner CCT (thin and stiff corneas) showed accelerated RNFL thinning by 0.72 mum/ye

218 ye morphology is similar in both species and cornea size relative to eye size (C:A ratio) is intermed

219 lar expansion in different organs, including cornea, skin and myocardium.

220 Patient demographics, donor cornea source, indications for grafting, complications,

221 Corneas were graded by cornea specialists according to the area and confluence

222 Of the 440 cornea specialists identified, 131 (29.8%) were female.

223 This study analyzed sex differences among cornea specialists with regards to academic rank, schola

224 Cornea, spleen, and liver were harvested at 0, 2, 5, 8,

225 ly definite edema (n = 15), in >=81% of FECD corneas suspicious for subclinical edema (n = 16), in <=

226 Corneas suspicious for subclinical edema that subsequent

227 Nitrate and nitrite levels were higher in cornea than in other eye parts, while lens contained the

228 igher isolation rate of S. aureus from their cornea than those with a single episode (p < 0.01) and a

229 OHTS subjects have thicker corneas than the general population.

230 African American subjects have thinner corneas than white subjects in the study.

231 y test demonstrated slight irritation to the cornea that resolved within 10 min.

232 bust antiviral CD4(+) T cell response in the cornea that was associated with protective immunity agai

233 ises after triple DMEK particularly occur in corneas that are flatter centrally than the periphery be

234 Molecular factors altered in corneas that develop haze post refractive surgery have b

235 ting of keratoconus stages (including normal corneas) the method is currently neither specific nor se

236 ssociated with the optical properties of the cornea, the absence of any large-scale changes following

237 After primary infection of the cornea, the virus enters latency within the trigeminal g

238 cus on assessing the center of this diseased cornea, there is growing evidence of peripheral involvem

239 On the posterior surface of the cornea, there was an endothelial rejection line (Khodado

240 In control corneas, there were no systematic changes with time.

241 such as keratoconus, a disease in which the cornea thins and bulges into a conical shape.

242 g an infrared reflective sensor aimed at the cornea to detect blinks.

243 ng factors that predispose clinically normal corneas to aberrant fibrosis post surgery and the role o

244 AS) OCT tube parameters, including posterior cornea-to-tube tip distance, tube angle-to-posterior cor

245 nd mainly involved in embryonic development, cornea transparency, and wound healing process.

246 al dysfunction is the leading indication for cornea transplant.

247 neal surface displacement changes in porcine corneas under a range of IOPs, from 0-60 mmHg.

248 asticity mapping of individual layers in the cornea using non-destructive elastography techniques adv

249 etimes observed in non-skin tissues (e.g. in cornea, vagina or thymus).

250 Ocular findings, such as cornea verticillata, cataracts, and retinal vascular tor

251 rvation Study (COS) for patients manifesting cornea verticillata.

252 ent (A2) took place earlier in time, and the cornea was moving faster during A2 in the OEs than in th

253 The optical quality of the cornea was preserved with lower HOAs than preoperatively

254 Relative mRNA expression of VEGF in the cornea was quantified by using qPCR.

255 Re-epithelization rate of the grafted cornea was significantly higher in the 0.4% and 2.0% rip

256 est and lowest corneal point in all measured cornea was stronger for subjects with a peripheral corne

257 esponding neighboring cells in ex vivo human corneas was measured.

258 ssion of Krt12, Krt14 and Pax6 in the mutant corneas was not altered after overexpression of Ctnnb1(D

259 A higher SP-A1, suggestive of a stiffer cornea, was associated with a faster rate of RNFL thinni

260 Biomechanical properties of the cornea were investigated by using the Ocular Response An

261 evoked by von Frey filaments applied on the cornea were lower in Piezo2-deficient mice compared with

262 -basal and epithelial nerve densities in the cornea were reduced in dry eye disease (DED).

263 uctural and biomechanical alterations of the cornea were screened.

264 ce of scar in keratoconic and nonkeratoconic corneas were all associated with an increased risk of po

265 l keratoplasty and participants with healthy corneas were assessed around noon the day before surgery

266 Corneas were clinically assessed for FECD and corneal ed

267 Three, 7 and 14 days after the treatment, corneas were collected and stained with FITC-conjugated

268 le for transplantation, but one-third of ASM corneas were compliant (ECD > 2000/mm).

269 At day 86, OC corneas were deswelled in a common hyperosmotic medium,

270 Corneas were graded by cornea specialists according to t

271 56 eyes of 156 adult participants with clear corneas were included.

272 After riboflavin imbibition, the corneas were irradiated at 3, 9, 18, and 30 mW/cm(2) whi

273 Donor corneas were prestripped and precut for DMEK and UT-DSAE

274 mmatory factors in ripasudil-treated grafted corneas were reduced.

275 Human and mouse corneas were subjected to immunohistochemistry to detect

276 m were also usable for emergency, 58% of ASM corneas were usable versus 33% in OC.

277 Porcine corneas were used, establishing two different groups: co

278 ed as conjunctival extensions onto the clear cornea, were diagnosed upon slit-lamp examination and on

279 e virus reactivates and migrates back to the cornea, where it restimulates the immune response, leadi

280 common hyperosmotic medium, but not the ASM corneas, which had remained thin.

281 nd DeltaNp63 was downregulated in the mutant corneas, which was associated with reduced corneal epith

282 d neurotrophic factor levels in diabetic rat corneas, which were partially restored by fenofibrate tr

283 uorescence staining was decreased in patient corneas, while KEAP1, which helps to degrade NRF2, was i

284 l collagen architecture of wounded embryonic corneas, whilst identifying temporal and spatial changes

285 multifactorial, degenerative disease of the cornea whose pathogenesis and underlying transcriptomic

286 show that treating the burnt surface of the cornea with collagenase effectively restores the tissue'

287 ncreasing biomechanical inhomogeneity in the cornea with keratoconus progression and biomechanical as

288 iffness plays a critical role in shaping the cornea with respect to intraocular pressure and physical

289 Corneas with a minimum stromal thickness <375 mum were e

290 g pachymetry and posterior elevation maps of corneas with a range of severity of FECD were evaluated

291 raphic features were all present in all FECD corneas with clinically definite edema (n = 15), in >=81

292 ferences were observed when comparing normal corneas with early-stage keratoconus/ in variables of th

293 Given that corneas with ECD > 1600/mm were also usable for emergenc

294 genes, and an increased level of lactate in corneas with progressing HSK lesions.

295 Similarly, infection of corneas with Pseudomonas aeruginosa resulted in secondar

296 cell depletion promoted reinnervation of HSK corneas with sensory nerves.

297 Targeted irradiation of mouse corneas with UVA induced reactive oxygen species (ROS) p

298 lation with slope in the central part of the cornea (with a radius of 1 mm) ranging from 0.48 (p < 0.

299 y and sympathetic nerve landscape within the cornea, with implications for the treatment of blinding

300 Using this cornea wound model, we investigated whether there is an