ライフサイエンスコーパス: corneal

1 preceding 6 months, history of glaucoma, and corneal abnormalities affecting IOP measurement.

2 tion in the WFS1 gene may be responsible for corneal abnormalities similar to keratoconus.

3 infection, chemosis, pyogenic granuloma, and corneal abrasion.

4 suppressed neovascularization and prolonged corneal allograft survival in an inducible nitric oxide

5 Corneal allograft survival is mediated by the variety of

6 ted coiled-coil protein kinase inhibitor, on corneal allograft survival.

7 re (OSDI), tear break-up time, evaluation of corneal and conjunctival staining, Schirmer I test, Coch

8 d these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially exp

9 Corneal and intraocular cultures showed positive results

10 unds of ocular adnexa, diplopia, superficial corneal and/or conjunctival injuries, and orbital fractu

11 Subjects with a peripheral corneal apex had stronger correlations with visual acuit

12 0.26 to 0.27 +/- 0.29 logMAR; P <.001), and corneal astigmatism (8.69 +/- 2.72 to 3.92 +/- 2.13 diop

13 Corneal astigmatism is common.

14 of 28 patients with co-existing cataract and corneal astigmatism were studied before and after simult

15 underwent placement of a sutureless biologic corneal badage device.

16 ocular response analyzer was used to measure corneal biomechanical properties, including corneal resi

17 PPPCD is associated with an alteration of corneal biomechanics and a novel missense variant in PRD

18 ransversely isotropic (NITI) model depicting corneal biomechanics.

19 1 ocular infections are the leading cause of corneal blindness.

20 ure alone and significantly better regressed corneal blood and lymphatic vessels at 1 week after the

21 The corneal buttons retrieved during keratoplasty were proce

22 f short contact time, tear dilution and poor corneal cell penetration.

23 is elevated due to increased half-life in a corneal cells.

24 ity of the bacteria to activate autophagy in corneal cells.

25 ese factors in activating autophagy in human corneal cells.

26 ltrate (OR 4.74, 2.68-8.40); and <=3 mm from corneal center (OR 2.82, 1.85-4.31), confirmed with comp

27 e) in the region within a 1 mm radius of the corneal centre in the opposite direction of the keratoco

28 Vitrectomy was performed as early as corneal clarity permitted.

29 To investigate its effect on corneal collagen architecture, x-ray scattering and elec

30 eal hysteresis, Goldmann-correlated IOP, and corneal-compensated IOP.

31 reater risk of developing vision-threatening corneal complications and therefore should be monitored

32 838 eyes, SVI was noted in 10%, and 2.5% had corneal complications at presentation.

33 Precise assessment of the corneal condition is necessary for deciding which type o

34 elpful tool used to diagnose and manage many corneal conditions, but its use has not been reported in

35 We studied the utility of corneal confocal microscopy (CCM) in detecting a reducti

36 We have utilised corneal confocal microscopy (CCM) to quantify the severi

37 tion in terms of change in CCCS, IVCM score, corneal crystal depth, and photophobia score; however, l

38 to inform the decision as to when to perform corneal cultures.

39 odds of failure were associated with steeper corneal curvature (HR, 1.74; P = 0.008), shallower anter

40 Preoperative BSCVA, Kmax, refraction, corneal cylinder, coma, central corneal thickness, and v

41 mprovement or response to therapy, change in corneal cystine crystal score (CCCS), in vivo confocal m

42 At the healed stage, a filling of the corneal defect by a hyporeflective thick epithelium, the

43 re is a critical need for new ways to repair corneal defects that drive proper epithelialization and

44 Corneal haze was quantified with corneal densitometry (Pentacam).

45 Visual impairment can be estimated with corneal densitometry.

46 ratoconus (KCN) and Down syndrome affect the corneal density and volume.

47 Studied parameters were the corneal density measured with Pentacam HR in 5 concentri

48 Younger age at surgery and smaller (<9.5 mm) corneal diameter at surgery conferred an increased risk

49 s corneal edema in 30 eyes (45.4%), enlarged corneal diameter in 32 eyes (48.5%), nystagmus in 15 chi

50 lgorithm may be useful for computer-assisted corneal disease diagnosis.

51 h implications for the treatment of blinding corneal disease.

52 most patients with visual impairment due to corneal diseases can be treated successfully with surger

53 identify many candidate loci in the study of corneal diseases that lead to severe visual impairment.

54 Only patients with corneal diseases without other ocular diseases were incl

55 restore the reading ability in patients with corneal diseases, which is a crucial part of visual reha

56 surgical management of patients with severe corneal diseases.

57 lopment of alternative, novel treatments for corneal dystrophies, which may substantially improve the

58 FBI) gene cause clinically distinct types of corneal dystrophies.

59 Fuchs' endothelial corneal dystrophy (FECD) is an RNA-mediated disease caus

60 al dysfunction in advanced Fuchs endothelial corneal dystrophy (FECD).

61 underwent DMEK mainly for Fuchs endothelial corneal dystrophy (FECD; 85.3%) or bullous keratopathy (

62 K for various indications (Fuchs endothelial corneal dystrophy [FECD]: n = 111; bullous keratopathy [

63 ectious keratitis, non-infectious keratitis, corneal dystrophy or degeneration, and corneal neoplasm.

64 Fuchs' endothelial corneal dystrophy was classified clinically into early-s

65 delineate the pathogenic mechanisms of human corneal dystrophy.

66 mber BGI insertion, we evaluated the central corneal ECD (CCECD) and peripheral corneal ECD (PCECD) i

67 e central corneal ECD (CCECD) and peripheral corneal ECD (PCECD) in the area of the tube; anterior ch

68 this study, we report two cases of GPA whose corneal ECD decreased significantly after phacoemulsific

69 occupied the central cornea, accompanied by corneal edema and neovascularization.

70 At presentation, there was corneal edema in 30 eyes (45.4%), enlarged corneal diame

71 Six episodes of reticular bullous epithelial corneal edema were identified in 5 eyes of 5 patients tr

72 For bullous keratoplasty and/or corneal edema, 8.6% and 22% of grafts underwent repeated

73 nflammation (13%), IOP spikes (6%), hyphema, corneal edema, and BCVA loss (all 4%).

74 cluding loss of ZO-1 junctional contacts and corneal edema, in female than male mice, characteristic

75 te to keep cornea dehydration which leads to corneal edema.

76 d a particular pattern of bullous epithelial corneal edema.

77 Although mechanical tests can quantify corneal elasticity ex vivo, they cannot be used clinical

78 provides an attractive non-contact probe of corneal elasticity.

79 No difference was found in postoperative corneal endothelial cell loss between groups.

80 for the establishment and expansion of human corneal endothelial cells (CEnC) has provided a source o

81 Human corneal endothelial cells (HCEnCs) were exposed to vario

82 When the corneal endothelial cells density (ECD) drops, the HCEC

83 The propagation and expansion of corneal endothelial cells has been widely reported.

84 symptoms during the day is pathognomonic for corneal endothelial dysfunction in advanced Fuchs endoth

85 Corneal endothelial dysfunction is the leading indicatio

86 of complications, whereas those with Fuchs' corneal endothelial dystrophy had the lowest.

87 ence of age on central corneal thickness and corneal endothelial morphology as well as to identify th

88 Normative data for corneal endothelial morphology in healthy Thai eyes show

89 The corneal endothelial parameters studied included central

90 EnC) has provided a source of transplantable corneal endothelium, with a significant potential to cha

91 We further show that in corneal epithelia, INSR interacts with the voltage-depen

92 d regenerative potential of cultivated human corneal epithelial cell sheets.

93 l epithelial cell types: insulin-insensitive corneal epithelial cells and insulin-sensitive bronchial

94 evels of BiP/GRP78, sXBP1 and GRP94 in human corneal epithelial cells treated with TNFalpha.

95 mportant sheddases of syndecan-1 shedding in corneal epithelial cells, which are natural targets of H

96 Corneal epithelial debridement experiments in young ACE2

97 e aged mice toward the development of severe corneal epithelial disease after exposure to a dry envir

98 significantly associated with 2 DE measures: corneal epithelial disruption and lower eyelid meibomian

99 imbus, represent essential components of the corneal epithelial stem cell niche, but, due to difficul

100 t VDR(-/-) and VDD significantly reduce both corneal epithelial wound healing and nerve density in di

101 rthermore, as observed in the LCD1 patients, corneal epithelial wound healing was significantly delay

102 Corneal epithelial wounds were created using an Algerbru

103 nfectious corneal ulcers by promoting faster corneal epithelialization and overall better recovery of

104 ting stress, aged mice developed more severe corneal epitheliopathy than young mice, which is associa

105 ualization of significant differences of the corneal epithelium and the Bowman's layer in en face map

106 In the corneal epithelium however, insulin selectively regulate

107 ation, a cell-fate switch from a transparent corneal epithelium to a keratinized, stratified squamous

108 depth should be stated as measured from the corneal epithelium to the lens.

109 In the acute stage, an absence of corneal epithelium, a scrambled appearance of the anteri

110 r PAX8 expression was observed in the normal corneal epithelium, iris sphincter pupillae muscle, iris

111 uction of the targeted protein expression in corneal epithelium.

112 ank is informed and the contraindications of corneal explantation are clarified.

113 found no sight-threatening complications or corneal failures during follow-up.

114 ts, 82.2% (60/73) had no prior experience in corneal FBs removal.

115 desmin, and vinculin) generated from rabbit corneal fibroblasts treated with transforming growth fac

116 In more advanced disease, we observed modest corneal flattening compared to baseline (Kmax 63.2 +/- 6

117 y present to the Emergency Department with a corneal foreign body (FB).

118 o the genetic architecture underlying normal corneal function, these results identify many candidate

119 3D En/DMT maps can diagnose active corneal graft rejection with excellent accuracy, sensiti

120 The overall corneal graft survival rates at 1, 5, 10, 15, and 20 yea

121 In addition, a global shortage of cadaveric corneal graft tissue critically limits accessibility to

122 ophthalmologic examination before and after corneal graft, including VA, assessed by the preferentia

123 For full-thickness corneal grafts, antifungal supplementation was less cost

124 ermination of the distributions and sizes of corneal guttae by an automated image analysis algorithm.

125 Corneal haze was quantified with corneal densitometry (P

126 Moreover, the conservative measure of corneal healing showed statistical significance at week

127 ts; however, this treatment led to secondary corneal hem- and lymphangiogenesis associated with signi

128 correlated with symptomatic and asymptomatic corneal herpesvirus infections.

129 aximum keratometry, thinnest pachymetry, and corneal higher-order aberrations were 60.89 +/- 10.9 D,

130 ncluding corneal resistance factor (CRF) and corneal hysteresis (CH).

131 Values of corneal hysteresis and corneal resistance factor correla

132 s (OEs) showed significantly lower values of corneal hysteresis and CRF than fellow eyes (9.0 +/- 1.8

133 roidal thinning, lower IOP change, and lower corneal hysteresis were significantly associated with po

134 lculation of corneal resistant factor (CRF), corneal hysteresis, Goldmann-correlated IOP, and corneal

135 ocular inflammation, ReSure sealant to seal corneal incisions, and Lifitegrast for dry eye represent

136 Corneal infections with antibiotic-resistant microorgani

137 ntry with subsequent downregulation of ACE2, corneal inflammation in Ace2(-/-) mice may have a simila

138 however, that these mice are "primed" for a corneal inflammatory response, which once initiated, wou

139 Visually significant corneal injuries and subsequent scarring collectively re

140 The high-density corneal innervation plays a pivotal role in sustaining t

141 imen including reduced systemic risk, better corneal integrity and reduced risk of ocular complicatio

142 nd contractility, we cultured primary rabbit corneal keratocytes on flexible substrata of varying sti

143 d subcellular pattern of force generation in corneal keratocytes treated with TGF-beta1.

144 eristics of crystal arrangement in different corneal layers and the assessment of corneal morphologic

145 morphological and structural changes of all corneal layers but the endothelium.

146 A recombinant human corneal limbal epithelial cell line expressing a LC3-GFP

147 No episodes of corneal melts or ulcers occurred.

148 Based on corneal microstructure, we introduce and fully character

149 fferent corneal layers and the assessment of corneal morphological changes with age.

150 WFS present a high prevalence of changes in corneal morphology compatible with the diagnosis of earl

151 pression and microscopic evaluation to study corneal morphology ex vivo.

152 The observed corneal multimodal imaging features in mucopolysaccharid

153 itis, corneal dystrophy or degeneration, and corneal neoplasm.

154 unknown whether FND itself causes a rebound corneal neovascularisation and whether that can be preve

155 receptor Neurokinin-1, significantly reduced corneal neovascularization in vivo.

156 CCM with automated corneal nerve analysis identifies nerve fibre damage and

157 interval (CI) [- 7.89, - 2.12], p = 0.001), corneal nerve branch density (mean difference: - 10.71 n

158 ected and corneal nerve fiber length (CNFL), corneal nerve fiber branch density (CNBD) and corneal ne

159 orneal nerve fiber branch density (CNBD) and corneal nerve fiber density (CNFD) were determined in bo

160 The images were randomly selected and corneal nerve fiber length (CNFL), corneal nerve fiber b

161 ysiology and vibration perception, but lower corneal nerve fibre density (20.1 +/- 0.87 vs. 24.13 +/-

162 Corneal nerve fibre density (mean difference: - 5.00 no/

163 ), 95% CI [- 23.58, - 5.92], p = 0.002), and corneal nerve fibre length (mean difference: - 2.57 mm/m

164 papillary neuroretinal layer thicknesses and corneal nerve length/density, respectively.

165 The new method generated 8-40% larger corneal nerve parameters compared to the standard proced

166 microscopy (CCM) in detecting a reduction in corneal nerve parameters in a large cohort of patients w

167 new, objective method showed a reduction in corneal nerve parameters in diabetic patients with and w

168 ealthy controls underwent CCM with automated corneal nerve quantification, MDS-UPDRS III, Hoehn and Y

169 endent analysis to enable objective unbiased corneal nerve quantification.

170 ameliorated both morphology and function of corneal nerves in patients with diabetes, thus suggestin

171 ing improvement in structure and function of corneal nerves.

172 male mouse mechano- and polymodal nociceptor corneal neurons display rapidly, intermediately and slow

173 c Piezo2-deficient mice, the distribution of corneal neurons displaying the three types of mechanical

174 taining of the somas and peripheral axons of corneal neurons responding only to mechanical force (pur

175 utes to transduction of mechanical forces by corneal nociceptors.SIGNIFICANCE STATEMENT The cornea is

176 showed a mildly injected conjunctiva with 1+ corneal oedema.

177 icroscopic findings suggest that the central corneal opacities represent gradual deposition of extrac

178 roves the surgical planning of children with corneal opacities.

179 Results from a bovine corneal opacity and permeability test demonstrated sligh

180 However, corneal opacity is considered a relative contraindicatio

181 To understand which irregular corneal parameters determine the visual quality in kerat

182 s and scale independent analysis of relevant corneal parameters in keratoconus of varying degrees.

183 primary DALK was superior to that for PK for corneal pathologies with functional endothelium.

184 ovessels and rapid allograft rejection after corneal penetrating keratoplasty.

185 eek and 3-month visual acuity and scar size, corneal perforation, and/or the need for therapeutic pen

186 tients with FECD underwent retroillumination corneal photography, followed by determination of the di

187 RP3 variant c.61C>G, a clinical examination, corneal photography, IVCM, light microscopy, and immunoh

188 pic refractive outcomes that worsened as the corneal power increased.

189 Subgroup analysis based on the steepest corneal power measured by biometry (stage 1: <=48 diopte

190 Corneal power measured by optical biometers was higher t

191 length, anterior chamber depth, and central corneal power were measured using the optical biometer.

192 Multivariable logistic regression found corneal profile and IOL type to be determinants of exten

193 Corneal profile and type of IOL implanted were the most

194 n initial platform for better characterizing corneal puncture injuries as seen in a military relevant

195 Here, we present a benchtop corneal puncture injury model for use with enucleated ey

196 Unfortunately, current corneal puncture injury models are not capable of produc

197 The benchtop model was evaluated with corneal puncture injury objects up to 4.2 mm in diameter

198 general examination including the Hirschberg corneal reflex test to detect manifest strabismus.

199 IOL power calculation in eyes with previous corneal refractive surgery and (2) evaluate the outcomes

200 corneal biomechanical properties, including corneal resistance factor (CRF) and corneal hysteresis (

201 Values of corneal hysteresis and corneal resistance factor correlated with the stage of K

202 Reichert Instruments) for the calculation of corneal resistant factor (CRF), corneal hysteresis, Gold

203 mined using immunofluorescence staining, and corneal rubbing was applied to confirm whether TPMDs occ

204 Corneal samples were obtained from human donors with and

205 The presence of corneal scarring (P < .00001; OR: 3.00), corneal ulcerat

206 ocular infections caused by HSV-1 can cause corneal scarring and blindness.

207 dophakic bullous keratopathy, postinfectious corneal scarring and thinning and keratoconus were the m

208 s for MK in high-risk, vascularized herpetic corneal scars achieves clinical outcomes that remain sta

209 After slit-lamp biomicroscopy and corneal Scheimpflug imaging, the Descemet endothelium co

210 In addition, assessment using corneal Scheimpflug tomography (Pentacam), refraction, c

211 Corneal scrapes were flooded with SmartProbes (BAC One o

212 ve or gram-negative bacteria or fungi within corneal scrapes.

213 This was associated with an improvement of corneal sensitivity and an increase of sub-basal nerve d

214 Mean corneal sensitivity improved significantly 1 year after

215 NK in all patients as well as improvement of corneal sensitivity in most of them thanks to nerve rege

216 Consistently, corneal sensitivity was decreased in PPARalpha (-/-) mic

217 luated using a Cochet-Bonnet aesthesiometer, corneal sensitivity was significantly decreased in diabe

218 st sensitivity has a higher correlation with corneal shape parameters than with visual acuity.

219 as enhanced by taking into consideration the corneal spherical aberration for the 8.0 mm zone at pre-

220 cal aberration (SA) will reduce the positive corneal spherical aberration induced in eyes by myopic L

221 Glaucoma suspect eyes with higher corneal SPs and lower CCT, suggestive of thin and stiff

222 Corneal SPs seem to act synergistically with CCT as risk

223 Baseline corneal SPs were measured using Corvis ST (Oculus Optikg

224 10 s, Schirmer score <= 5 mm and fluorescein corneal staining >= grade 1.

225 metrics, including tear breakup time (TBUT), corneal staining and eyelid margin measurements, meibum

226 per eyelid margin-to-reflex distance (MRD1), corneal staining, static and dynamic validated scoring f

227 IOP, corneal status, and endothelial cell count values were i

228 Corneal stiffness plays a critical role in shaping the c

229 ted with PPPCD was a significantly increased corneal stiffness.

230 Corneal storage for the very long term, without degradat

231 mporal direction immediately after preparing corneal strips from the two groups.

232 stals were mostly localized in the posterior corneal stroma with the depth of crystal deposition show

233 involve the anterior to middle layers of the corneal stroma, and the disease is primarily a keratitis

234 ccupied the anterior to middle layers of the corneal stroma.

235 esthesiometry, and confocal biomicroscopy of corneal sub-basal plexus (SBP).

236 o-tube tip distance, tube angle-to-posterior corneal surface distance, tube tip-to-anterior iris dist

237 Parameters characterising the corneal surface's correlations with contrast sensitivity

238 On the anterior corneal surface, Q-value, spherical aberration, and ecen

239 these axes as parameters characterising the corneal surface; (b) by projecting circles with differen

240 was stable; 3 implant-treated subjects with corneal TEAEs had >2-line BCVA loss at their last visit.

241 at evaluating the time-course changes of pre-corneal tear film after simultaneous phacoemulsification

242 Pre-corneal tear film stability was assessed by measuring th

243 our percent of the OHTS subjects had central corneal thickness > 600 mum.

244 Effect of age, sex, IOP, central corneal thickness (CCT) and AXL, disc area, and signal s

245 The central corneal thickness (CCT) and biometry of all subjects wer

246 To compare central corneal thickness (CCT) values measured by three differe

247 Goldmann applanation tonometer, and central corneal thickness (CCT) was measured using an ultrasonic

248 best-corrected visual acuity (BCVA), central corneal thickness (CCT), and complications.

249 othelial parameters studied included central corneal thickness (CCT), endothelial cell density (ECD),

250 ing age, intraocular pressure (IOP), central corneal thickness (CCT), optic nerve head appearance, an

251 1), average K (0.14; P < 0.001), and central corneal thickness (r = 0.10; P < 0.001) correlated posit

252 linear regression model adjusted for central corneal thickness and age.

253 to determine the influence of age on central corneal thickness and corneal endothelial morphology as

254 n (45.19 D vs. 43.76 D; P < 0.001), and mean corneal thickness at the thinnest point (475 mum vs. 536

255 and for quantitative traits such as central corneal thickness have identified several genetic loci t

256 Central corneal thickness influences intraocular pressure (IOP)

257 tment Study (OHTS) and determined if central corneal thickness is related to race.

258 ft and increased glare paralleling increased corneal thickness may particularly contribute to subject

259 We examined the central corneal thickness of subjects in the Ocular Hypertension

260 egional TCT, and central-to-peripheral total corneal thickness ratio (CPTR) were evaluated and correl

261 Mean central corneal thickness was 573.0 +/- 39.0 mum.

262 Central corneal thickness was determined with ultrasonic pachyme

263 factors associated with greater mean central corneal thickness were younger age, female gender, and d

264 refraction, corneal cylinder, coma, central corneal thickness, and vision function were statisticall

265 ed for age, gender, race, diagnosis, central corneal thickness, follow-up time, and baseline disease

266 raphy, refraction, endothelial cell density, corneal thickness, haze, intraocular pressure, and visua

267 y aimed to analyze the daily fluctuations of corneal thickness, refraction, and (glare) visual acuity

268 gistic regression model included the minimal corneal thickness, the anterior coma to 90 degrees and p

269 bclinical keratoconus depends on the minimum corneal thickness, the anterior coma to 90 degrees and t

270 nt (MRSE), endothelial cell count (ECC), and corneal thickness.

271 ), more astigmatism (P = .002), more central corneal thinning (P = .002), and was protective to the e

272 ost-effective analysis of the base case with corneal tissue stored in CSM or CSM supplemented with an

273 al transplant have access to cadaveric donor corneal tissue.

274 outcomes in selected cases that meet certain corneal topographic criteria.

275 c profile, clinical features, visual acuity, corneal topography, aberrometry, and biomechanical and c

276 mm(2), 95% CI [- 16.93, - 4.48], p = 0.003), corneal total branch density (mean difference: - 14.75 n

277 endothelial cell density (ECD in cells/mm), corneal transparency and thickness.

278 nts who could benefit from a sight-restoring corneal transplant have access to cadaveric donor cornea

279 Using 2 well-established models of corneal transplantation (low-risk and high-risk models),

280 aract surgery (OR, 0.31; 95% CI, 0.30-0.32), corneal transplantation (OR, 0.39; 95% CI, 0.31-0.49), a

281 the etiology, visual outcome and survival of corneal transplantation in children and to identify the

282 ft tissue critically limits accessibility to corneal transplantation in some parts of the world.

283 risk of steroid-induced IOP elevation after corneal transplantation relative to placebo.

284 re a valuable option in obtaining grafts for corneal transplantation, which is why we are working tow

285 stantial comorbidities were noted, including corneal trauma (20%), hyphema (41%), iris trauma (62%),

286 common occurrences following minor or major corneal trauma.

287 activated currents of different kinetics in corneal trigeminal neurons and contributes to transducti

288 edema, poor presenting visual acuity, larger corneal ulcer diameter, and causative organisms were not

289 th NK with a persistent epithelial defect or corneal ulcer, treated with topical rhNGF, and age-match

290 of corneal scarring (P < .00001; OR: 3.00), corneal ulceration (P < .00001; OR: 12.96), low Schirmer

291 In patients with SS, severity of dryness, corneal ulceration and scarring, cataract, and glaucoma

292 y outcome measure was the odds of developing corneal ulceration or perforation in the first year.

293 apy in treating sight-threatening infectious corneal ulcers by promoting faster corneal epithelializa

294 ved AM as an adjuvant therapy for infectious corneal ulcers.

295 density in 0-2 mm and 2-6 mm (P > 0.05) and corneal volume (P = 0.519) between Down-KCN and Down-non

296 5 +/- 2.55, and 15.78 +/- 2.67 GSU, and mean corneal volume was 57.45 +/- 4.37, 56.99 +/- 3.46, and 6

297 thickness of the cornea), and the 10 mm zone corneal volume.

298 After surgery or traumatic injury, corneal wound healing can cause a scarring response that

299 ts provide the first evidence that following corneal wounding immune cells are activated to travel al

300 Linear corneal wounds that traversed the epithelial layer, Bowm