ライフサイエンスコーパス: corneal epithelium

1 cells (epidermis/limbus) or K3/K12(+) cells (corneal epithelium).

2 uction of the targeted protein expression in corneal epithelium.

3 optimized to maximize the sensitivity of the corneal epithelium.

4 tion to differentiation in the epidermis and corneal epithelium.

5 on is up-regulated in diseased epidermis and corneal epithelium.

6 m development and daily renewal of the adult corneal epithelium.

7 face, acting to protect the integrity of the corneal epithelium.

8 red for P. aeruginosa traversal of the human corneal epithelium.

9 II (Tbr2) was conditionally ablated from the corneal epithelium.

10 olarity, and separation of lens vesicle from corneal epithelium.

11 regulator-this time for nerves entering the corneal epithelium.

12 ves by increasing nerve branching within the corneal epithelium.

13 ce that express abundant syndecan-1 in their corneal epithelium.

14 egulated level of p68 RNA helicase in mutant corneal epithelium.

15 o the mouse corneal epithelium and the human corneal epithelium.

16 itating gammadelta T cell migration into the corneal epithelium.

17 in ex vivo tissues and in vitro cultures of corneal epithelium.

18 MBP, and MPZL1 mRNAs were expressed only in corneal epithelium.

19 RP1 is expressed at high levels in the mouse corneal epithelium.

20 itical for the proper differentiation of the corneal epithelium.

21 -/-) mice showed phosphorylated Stat3 in the corneal epithelium.

22 downregulation of Bmp4 and DeltaNp63 in the corneal epithelium.

23 e bundles form a subbasal plexus beneath the corneal epithelium.

24 Sey/Sey cells were absent from the lens and corneal epithelium.

25 re localized in basal layer of entire murine corneal epithelium.

26 r removal of a 2-mm diameter area of central corneal epithelium.

27 tion of soluble precursors in UVB-stimulated corneal epithelium.

28 differentiated (TD) cell populations of the corneal epithelium.

29 onditionally overexpresses reporter genes in corneal epithelium.

30 cell is an important area of interest in the corneal epithelium.

31 olecular mechanism(s) of PA infection in the corneal epithelium.

32 ucrin gene expression in the differentiating corneal epithelium.

33 d as a model to study gene expression in the corneal epithelium.

34 ble surface and result in desiccation of the corneal epithelium.

35 study to delineate their roles in the human corneal epithelium.

36 he recruitment of MHC class II(+) LCs to the corneal epithelium.

37 ert different molecular effects in the human corneal epithelium.

38 ately differentiate to form the multilayered corneal epithelium.

39 mobilization of MHC class II(+) LCs into the corneal epithelium.

40 main changes of these components occurred in corneal epithelium.

41 iate, and desquamate similar to normal human corneal epithelium.

42 tant roles in maintaining normal function of corneal epithelium.

43 e immunoreactivity in both RCE cells and rat corneal epithelium.

44 rneal epithelial cells and in the intact rat corneal epithelium.

45 eye, which is detected by the nerves in the corneal epithelium.

46 expression to the entire lens but not to the corneal epithelium.

47 e cells at producing progeny to populate the corneal epithelium.

48 ith fluorescein to assess the quality of the corneal epithelium.

49 th factor (OGF), [Met(5)]-enkephalin, in the corneal epithelium.

50 uble protein), which resembles the zebrafish corneal epithelium.

51 the normal homeostatic turnover rate of the corneal epithelium.

52 wing, but not in superficial, cells of human corneal epithelium.

53 l, as well as suprabasal, cells of adult rat corneal epithelium.

54 epithelium, and apoptosis in the basal layer corneal epithelium.

55 ed the cell proliferation rate in the rabbit corneal epithelium.

56 owed that destrin is highly expressed in the corneal epithelium.

57 eted products, and ability to desquamate the corneal epithelium.

58 fibrosis transmembrane regulator in diabetic corneal epithelium.

59 key protein in maintaining integrity of the corneal epithelium.

60 iform and round-shaped, were detected in the corneal epithelium.

61 tem cells (LSCs) that continuously renew the corneal epithelium.

62 characterized by conjunctivalization of the corneal epithelium.

63 Bmal1, Per2, Cry1, and Rev-erbalpha) in the corneal epithelium.

64 results in precocious stratification of the corneal epithelium.

65 lacrimal gland and mitogenic activity at the corneal epithelium.

66 on between 4-HNE and oxidative stress in the corneal epithelium.

67 face that may cause persistent damage to the corneal epithelium.

68 eripheral epithelium on wound healing of the corneal epithelium.

69 cause inflammation and keratinization of the corneal epithelium.

70 TLR4, a similar expression, occurred in the corneal epithelium.

71 ate the homeostasis and wound healing of the corneal epithelium.

72 x) induction to overexpress TGF-alpha in the corneal epithelium.

73 crog water-soluble protein) than the ventral corneal epithelium (5-7 cell layers; approximately 1.63

74 In the acute stage, an absence of corneal epithelium, a scrambled appearance of the anteri

75 % reduction in internalized PA in the rabbit corneal epithelium after 24 hours (P = 0.03).

76 eta6 expression was upregulated in migrating corneal epithelium after a keratectomy.

77 expression increases at the leading edge of corneal epithelium after injury in an organ culture mode

78 transient amplifying cells makes the limbal/corneal epithelium an exceptionally suitable system for

79 Regular corneal epithelium and a quiet ocular surface were obtai

80 coherence tomography (UHR-OCT) can image the corneal epithelium and Bowman's layer and measurement th

81 he entire vertical thickness profiles of the corneal epithelium and Bowman's layer can provide valuab

82 power of vertical thickness profiles of the corneal epithelium and Bowman's layer imaged by UHR-OCT

83 Vertical thickness profiles of the corneal epithelium and Bowman's layer were measured by U

84 IL-6, and IL-1beta protein were observed in corneal epithelium and conjunctiva from dry eye mice.

85 mulated IL-33 mRNA and protein expression by corneal epithelium and conjunctiva in wild type, but not

86 ion of chemokines and their receptors by the corneal epithelium and conjunctiva of C57BL/6 and BALB/c

87 a, MIP-1beta, IP-10, and MIG proteins in the corneal epithelium and conjunctiva of C57BL/6 mice.

88 e protease that kills both human and hamster corneal epithelium and degrades collagen.

89 od vessels, optic nerve vascular structures, corneal epithelium and endothelium, and lens epithelium.

90 OPN was present in the trabecular meshwork, corneal epithelium and endothelium, iris, ciliary body,

91 rnea is the presence of Fas ligand (FasL) on corneal epithelium and endothelium.

92 man and mouse corneas showed staining in the corneal epithelium and endothelium.

93 degeneration developed, with thinning of the corneal epithelium and eventually perforation after 7 da

94 s play important roles in the homeostasis of corneal epithelium and hair follicles.

95 ptor that is constitutively expressed in the corneal epithelium and has been implicated in many homeo

96 tral amino acid transporter, LAT1, on rabbit corneal epithelium and human cornea.

97 s envelope precursors are expressed in human corneal epithelium and in HCECs, acute UVB stress differ

98 madelta T cells in the limbal and peripheral corneal epithelium and in the corneal stroma adjacent to

99 ium, is strongly constitutively expressed by corneal epithelium and is mechanistically responsible fo

100 TSLP was found to be expressed by human corneal epithelium and its cultures.

101 The role of the corneal epithelium and limbus in corneal avascularity an

102 icroscopy provides objective measures of the corneal epithelium and may significantly improve the eva

103 epidermis, palpebral and bulbar conjunctiva, corneal epithelium and meibomian glands.

104 We investigated changes in the corneal epithelium and nerve morphology using three-dime

105 YRP1 is a novel antimicrobial protein of the corneal epithelium and protects the ocular surface from

106 reaks down, allowing bacteria to bind to the corneal epithelium and resulting in spontaneous keratiti

107 ase was constitutively expressed in both the corneal epithelium and several retinal layers before int

108 nous VEGF expression was up-regulated in the corneal epithelium and stroma after wounding.

109 t to the corneal stroma, was elevated in the corneal epithelium and stroma of control, but not MyD88(

110 Upregulated MMPs and TIMP-1 in the corneal epithelium and stroma of infected eyes correlate

111 The expression of TLR4 by the corneal epithelium and stroma was evaluated using real-t

112 Sema7a was expressed in the corneal epithelium and stromal keratocytes, but was more

113 ics of keratoconus, including visual acuity, corneal epithelium and stromal thickness changes, cornea

114 : anterior stromal scars, dystrophies of the corneal epithelium and the anterior stroma, and elevated

115 ualization of significant differences of the corneal epithelium and the Bowman's layer in en face map

116 PGLYRP1 was localized to the mouse corneal epithelium and the human corneal epithelium.

117 for KLF6 protein was evident at E15.5 in the corneal epithelium and the stroma.

118 nclusion, 4-HNE plays an oxidant role in the corneal epithelium and this work provides a new strategy

119 replicated and spread normally in the mouse corneal epithelium and to the trigeminal ganglia.

120 e IVCM sections showed structures resembling corneal epithelium and vascular structures.

121 on, viral plaques could be visualized in the corneal epithelium and viral DNA copies were detected in

122 PRCE cells, loss of the superficial layer of corneal epithelium, and apoptosis in the basal layer cor

123 activation of NF-kappaB in the ciliary body, corneal epithelium, and retinal wall of the rat eye.

124 NOS, and COX-2 proteins in the ciliary body, corneal epithelium, and retinal wall was also significan

125 ssion was sporadically detected in the basal corneal epithelium, and the number of K12-positive basal

126 Pax6 is present in the adult corneal epithelium, and we showed that the amount of Pax

127 BrdU-labeled pairs of cells over the entire corneal epithelium at day 2 compared with the number in

128 Type IX collagen localised to the corneal epithelium at E14.

129 he location of each BrdU-labeled cell in the corneal epithelium (basal or suprabasal) was determined.

130 nase protein expression was primarily in the corneal epithelium before corneal infection and was also

131 Key issues in corneal epithelium biology are the mechanism for corneal

132 was reduced at the leading edge of a healing corneal epithelium both in vivo and in vitro.

133 P2X(7) was present in the WT corneal epithelium but was not detected in P2X(7)(-/-) m

134 d encoding S. pyogenes Cas9 and sgRNA to the corneal epithelium by intrastromal injection and acheive

135 After removal of the corneal epithelium by scraping, re-epithelialization was

136 Functionally, corneal epithelium can be regenerated in cultures from c

137 The increased beta-galactosidase activity in corneal epithelium caused by doxycycline returned to bas

138 minantly present on basal cells of the mouse corneal epithelium (CE) throughout development and in th

139 lium: cK12-positive and MUC1-positive cells; corneal epithelium: cK12-positive and MUC1-negative cell

140 y revealed successful regeneration of normal corneal epithelium (CK3(+)/12(+)) without admixture of c

141 This squamous metaplasia of Pnn mutant corneal epithelium closely correlated with significantly

142 Tear fluid and the corneal epithelium combine to make a formidable defense

143 After the last SRW challenge, the corneal epithelium, conjunctiva, and cervical lymph node

144 s of CD11c, TSLPR, and OX40L detected in the corneal epithelium, conjunctiva, and cervical lymph node

145 t intact, TGF-beta2 remained confined to the corneal epithelium, consistent with the absence of a fib

146 The corneal epithelium consists of stratified epithelial cel

147 layers at postnatal day 21 (P21), the mutant corneal epithelium contained 1-2 or 2-3 cell layers afte

148 RNA was purified from isolated corneal epithelium, corneal stroma, and primary cultures

149 inical relevance of promoting the healing of corneal epithelium debridement.

150 eneration of a functional and transplantable corneal epithelium derived from human induced pluripoten

151 and suggest the novel phenomenon that human corneal epithelium-derived TSLP may serve as a link betw

152 ferentiation, and plays an important role in corneal epithelium development and daily renewal of the

153 together to specify LSCs, and WNT7A controls corneal epithelium differentiation through PAX6.

154 14-3-3sigma is essential for corneal epithelium differentiation, and plays an importa

155 The corneal epithelium displayed histological features of th

156 Pnn mutant corneal epithelium displayed the loss of corneal epithel

157 In the mouse, the corneal epithelium does not become fully mature until 3

158 Injury to the corneal epithelium downregulates the expression of PTEN

159 no degenerative changes were observed in the corneal epithelium during cultivation using histology fo

160 on of the antimicrobial peptide LL-37 in the corneal epithelium during wound healing and to investiga

161 maging unstained cells within the stratified corneal epithelium during wound healing were made.

162 on was used to observe indentation of bovine corneal epithelium, endothelium, and stroma by a spheric

163 mal cells and scleral fibroblasts but not in corneal epithelium, endothelium, ciliary epithelium, cho

164 iffusion of RF across embryonic day 18 chick corneal epithelium ex vivo was monitored using confocal

165 sion in actively proliferating primary human corneal epithelium explant cultures, indicating that ALD

166 i were analyzed for their ability to bind to corneal epithelium, express MBP, and produce a cytopathi

167 protease (MIP133) mediates apoptosis of the corneal epithelium, facilitates corneal invasion, and de

168 However, after removal of the corneal epithelium, fibroblasts are activated and had re

169 he antioxidant and prooxidant enzymes in the corneal epithelium, followed by the imbalance between me

170 inguishing the mode of keratin expression in corneal epithelium from that of all other stratified epi

171 ive hemidesmosomes, leading to detachment of corneal epithelium from the underlying stroma, which in

172 a constitutively active form of STAT3 in the corneal epithelium had abnormal features, including corn

173 ogether, these findings demonstrate that the corneal epithelium has functional TLR2 and -9, and that

174 ression is upregulated in regenerating human corneal epithelium, has antibacterial activity against o

175 In the corneal epithelium however, insulin selectively regulate

176 d eyes (90%), revealing the presence of just corneal epithelium in 7 cases, just conjunctival epithel

177 bsequent intracellular bacterial load in the corneal epithelium in a contact lens infection model in

178 oth the proliferation and differentiation of corneal epithelium in a novel Krt12-rtTA/tet-O-FGF-7 dou

179 promotes differentiation and recapitulates a corneal epithelium in a three-dimensional raft culture m

180 ght microscopy revealed clear healing of the corneal epithelium in all groups except for some cases i

181 of MMP-1, -3, -9, and -10 transcripts in the corneal epithelium in C57BL/6 mice, but had no effect on

182 LSCs are maintained and differentiated into corneal epithelium in healthy individuals and which key

183 ted beyond the very superficial layer of the corneal epithelium in mice with intact corneas even afte

184 ICAM-1 expression by corneal epithelium in response to epithelial abrasion ap

185 ications for preventing cornification of the corneal epithelium in response to the hyperosmolar tear

186 copy showed that 46.2% of patients exhibited corneal epithelium in the central and peripheral cornea,

187 lts in a loss of hINV gene expression in the corneal epithelium in vivo and in cultured corneal epith

188 role of lipid rafts in PA internalization by corneal epithelium in vivo, in vitro, and after contact

189 lanted limbal cells' ability to reconstitute corneal epithelium in vivo.

190 vitro, but it does not penetrate the intact corneal epithelium in vivo.

191 ion only happened in the limbal, but not the corneal, epithelium in airlift, but not submerged, cultu

192 expression profile of connexins in the human corneal epithelium (in vivo) and in cultured primary cor

193 es, but showed irregularities underneath the corneal epithelium, in Bruch's membrane and in the iris.

194 were highly restricted in spread within the corneal epithelium, in the case of mutant 277 to only 4

195 Overexpression of TGF-alpha in the corneal epithelium induces changes in anterior segment m

196 Abrasion of murine corneal epithelium induces neutrophil emigration through

197 Complete transformation of the corneal epithelium into a stratified epithelium that exp

198 y enhances the diffusion of RF across intact corneal epithelium into the stroma.

199 r PAX8 expression was observed in the normal corneal epithelium, iris sphincter pupillae muscle, iris

200 The detection of the MUC5AC transcript in corneal epithelium is a more sensitive method to diagnos

201 rom neuroectoderm via the optic vesicle, the corneal epithelium is descended from surface ectoderm, w

202 The normal corneal epithelium is endowed with CD11c(+) Langerin+ ce

203 The basal layer of limbal and central corneal epithelium is enriched in stem cells and transie

204 se results suggest that the integrity of the corneal epithelium is important for (lymph)angiogenic pr

205 Unlike many epithelial tissues, the corneal epithelium is insulin insensitive, meaning it do

206 onship between nerve loss and effects on the corneal epithelium is limited.

207 Gap junction communication in the human corneal epithelium is mediated by Cx26, -30, -31.1, and

208 The corneal epithelium is one of the most highly innervated

209 The corneal epithelium is the outermost layer of the cornea

210 The Anableps dorsal corneal epithelium is thicker (>20 cell layers), flatter

211 The mucin-rich environment of the intact corneal epithelium is thought to contribute to the preve

212 membrane duplicating or insinuating into the corneal epithelium layer, or both, and the presence of h

213 Pnn depletion in developing mouse corneal epithelium led to disrupted alternative splicing

214 It is suggested that PAX6 involves corneal epithelium lineage-specific differentiation; how

215 In the central human corneal epithelium, loss of DeltaNp63 occurs in all surf

216 ative cells), and cell morphologic features (corneal epithelium: multilayered polygonal and flat cell

217 LL-37 peptide was present throughout the corneal epithelium (n=4).

218 show that conditional ablation of Srf in the corneal epithelium of a diseased Dstn(corn1) cornea resu

219 o effect on levels of MMP transcripts in the corneal epithelium of BALB/c mice.

220 a-galactosidase induction was limited to the corneal epithelium of bitransgenic mice fed doxycycline.

221 The central corneal epithelium of C57BL/6 and gene knockout mice was

222 Corneal epithelium of C57BL/6, TLR2(-/-), TLR9(-/-), and

223 role of TRIF in host inflammatory responses, corneal epithelium of C57BL/6, TLR3(-/-), TRIF(-/-), and

224 -mm diameter punch was placed on the abraded corneal epithelium of either untreated or cyclophosphami

225 ings demonstrate that nerve terminals in the corneal epithelium of mice and guinea pigs can be distin

226 and neurochemistry of nerve terminals in the corneal epithelium of mice and guinea pigs.

227 Tissue-specific deletion of Pbx1 in the corneal epithelium of mice resulted in corneal dystrophy

228 or cervical ganglion occurred throughout the corneal epithelium of mice, but only in the basal epithe

229 ate the role of the Pbx1 TALE protein in the corneal epithelium of mice.

230 marker of oxidative stress, in HCE cells and corneal epithelium of rats by immunofluorescent staining

231 Unlike the corneal epithelium of the littermate controls, which con

232 Ca2+]i (Ca2+ transients) in PSNTs within the corneal epithelium of the rat.

233 ed by intracellular deposition of C3d in the corneal epithelium of vaccinated animals following chall

234 Similar to the corneal epithelium, only some of the conjunctival epithe

235 by any significant increase in thickness of corneal epithelium or contact lens, respectively.

236 not affect adherence of trophozoites to the corneal epithelium or protect corneal epithelial or stro

237 Corneal epithelium over the entire cornea was topographi

238 ecific to the structure and functions of the corneal epithelium, particularly keratin 3 (KRT3) and ke

239 To reveal their function in the corneal epithelium, PAX6 isoforms, along with reprogramm

240 FIH-1 and provides new insight into how the corneal epithelium regulates its energy requirements.

241 Corneal epithelium relies on abundant glycogen stores as

242 nt fibrosis post surgery and the role of the corneal epithelium remains unknown.

243 rile 1.0 microM latex beads into the central corneal epithelium renders Chinese hamsters resistant to

244 Toll-like receptors (TLRs) expressed by the corneal epithelium represent a first line of host defens

245 ing tear instability and to test whether the corneal epithelium responds to transient hyperosmolar st

246 AC amplicon was detected in 56 of 59 (94.9%) corneal epithelium samples.

247 Healthy corneal epithelium showing survival of limbal stem cells

248 nts that develop irregular thickening of the corneal epithelium, similar to that observed in human co

249 understanding of the molecular basis of the corneal epithelium specific phenotype.

250 acterize a Krt12-Cre knock-in mouse line for corneal epithelium-specific gene ablation and to analyze

251 eal epithelium biology are the mechanism for corneal epithelium stem cells to maintain the corneal ep

252 ear upregulates mannosylated proteins on the corneal epithelium, stimulates MIP133 secretion, and exa

253 Mouse corneal epithelium stratification is the consequence of

254 in-of-function mutant (Ctnnb1(cGOF)) retards corneal epithelium stratification.

255 ts reconstituted in vitro with normal BALB/c corneal epithelium survived indefinitely when placed in

256 In ethanol-exposed corneal epithelium Tbeta(4) treatment inhibited caspase-

257 erplay between bacteria, tear fluid, and the corneal epithelium that determines health as the usual o

258 r removal of a 2-mm diameter area of central corneal epithelium that did not directly injure the limb

259 Our data identify a few novel factors in the corneal epithelium that may define a patient's risk to d

260 can be sorted and expanded ex vivo to form a corneal epithelium that recovers function in an experime

261 In corneal epithelium, the transgene expression causes decr

262 on of cornified envelope precursors in human corneal epithelium, their expression in human corneal ep

263 ean subbasal nerve density (P < 0.001), mean corneal epithelium thickness (P = 0.006), and mean corne

264 retinopexy was associated with a decrease in corneal epithelium thickness (r(2) = 0.42; P = 0.006) an

265 ation, a cell-fate switch from a transparent corneal epithelium to a keratinized, stratified squamous

266 The authors used wound healing of mouse corneal epithelium to examine the role TGF-beta signalin

267 synthetic peptide, NC-1059, can modulate the corneal epithelium to increase the permeation of therape

268 er (K), preoperative anterior chamber depth (corneal epithelium to lens), and horizontal corneal diam

269 The exposure of corneal epithelium to S. aureus induced neutrophil recru

270 herpes simplex virus (HSV) travels from the corneal epithelium to sensory ganglia then returns to th

271 epth (ACD), defined as the distance from the corneal epithelium to the anterior lens surface; anterio

272 depth should be stated as measured from the corneal epithelium to the lens.

273 After a period of epithelial thinning, the corneal epithelium undergoes differentiation to an epide

274 Specific factors from the corneal epithelium underlying the stimulation of stromal

275 receptor, the expression of proteins in the corneal epithelium was altered and wound healing was com

276 After wound closure, the central corneal epithelium was completely replaced by K14(+) lim

277 f NC-1059 peptide on RF diffusion across the corneal epithelium was concentration and time dependent.

278 ine-rich protein [SPRR]-2) expression by the corneal epithelium was evaluated by laser scanning confo

279 uthanatized at different time points and the corneal epithelium was immunocytochemically stained for

280 measured by the duration for which a healthy corneal epithelium was maintained.

281 of this sensor, the permeability of a rabbit corneal epithelium was monitored by applying a solution

282 The GFP expression in the corneal epithelium was nearly ubiquitous up to about 1 w

283 The expression of MUC-1 and -4 mRNA by the corneal epithelium was reduced in NRTN(-/-) mice.

284 After stabilization, the corneal epithelium was removed with a rotating bristle b

285 The corneal epithelium was removed with the use of a corneal

286 invasion was noted when the limbal, but not corneal, epithelium was recombined with the limbal strom

287 RNA-Seq data from corneal epithelium were compared to epidermal hair folli

288 Goblet cells in the corneal epithelium were detected by light microscopy, an

289 d postoperative visual acuity and quality of corneal epithelium were evaluated.

290 Stratification and differentiation of the corneal epithelium were not reduced after Notch inhibiti

291 y, Akt signaling and glycogen content of the corneal epithelium were significantly decreased in c-kit

292 or cells to contribute fully not only to the corneal epithelium, where Pax6 is expressed at high leve

293 ephrin signaling proteins are present in the corneal epithelium, where their function remains unknown

294 e suprabasal and/or superficial cells of the corneal epithelium, whereas the K14 expression was restr

295 wer gammadelta T cells resident in unwounded corneal epithelium, which failed to increase in response

296 in sensory neurons supplying the guinea pig corneal epithelium, which have well-defined modalities i

297 itor cells (LSCs), and deficiency in LSCs or corneal epithelium--which turns cornea into a non-transp

298 Histological analysis revealed a stratified corneal epithelium with at least three layers in all PF-

299 Success was defined as a stable corneal epithelium without conjunctivalization.

300 ration of transparent, avascular, and stable corneal epithelium without neovascularization in central