ライフサイエンスコーパス: coronary artery

1 giography having an acutely occluded culprit coronary artery.

2 re also identified in the neointima of human coronary arteries.

3 on for non-left anterior descending diseased coronary arteries.

4 phenotype in pulmonary but not in aortic and coronary arteries.

5 thelial cells (ECs) of human atherosclerotic coronary arteries.

6 though fat while acutely sparing nearby the coronary arteries.

7 d at 90 to 100 W for 4 minutes at sites near coronary arteries.

8 he highest doses of exercise training on the coronary arteries.

9 condition is remodelling of intramural small coronary arteries and arterioles.

10 ith endothelial dysfunction in patients with coronary artery and/or cardiovascular disease.

11 data on intravascular lithotripsy use in the coronary arteries, and future directions for adoption of

12 redominantly afflicts young children, causes coronary artery aneurysms and can result in long-term ca

13 sease in developed nations and can result in coronary artery aneurysms and death.

14 Coronary artery aneurysms develop in some untreated chil

15 pment of pulmonary edema on thoracic images, coronary artery aneurysms, and extensive right iliac fos

16 omputed tomography was carried out excluding coronary artery aneurysms.

17 myocardial injury, shock, and development of coronary artery aneurysms.

18 Coronary-artery aneurysms (z scores >=2.5) were document

19 isk score, coronary artery calcium score, or coronary artery area stenosis.

20 mic vascular disease that included aorta and coronary artery atheroma, cardiac hypertensive disease,

21 ty for fat penetration and sparing of nearby coronary arteries because of cooling endoluminal flow.

22 ery followed by the left anterior descending coronary artery branch.

23 Coronary artery bypass graft (CABG) surgery is the gold-

24 his study is to compare HCR and conventional coronary artery bypass graft (CABG) surgery medium-term

25 Individuals who underwent colon resection, coronary artery bypass graft (CABG), lung resection, or

26 atients who underwent colectomy/proctectomy, coronary artery bypass graft (CABG), pancreaticoduodenec

27 with low risk of immediate complications, or coronary artery bypass graft (CABG), with improved long-

28 s (SVGs) occlude during the first year after coronary artery bypass graft surgery (CABG) despite aspi

29 total of 60 patients with CAD indicated for coronary artery bypass graft surgery (CABG) were include

30 LAA exclusion during isolated coronary artery bypass graft surgery in patients with at

31 tal, we analyzed 253 287 patients undergoing coronary artery bypass graft surgery, 7.0% of whom recei

32 with atrial fibrillation undergoing isolated coronary artery bypass graft surgery.

33 tality by race group for patients undergoing coronary artery bypass grafting (CABG) between 2011 and

34 taneous coronary intervention (PCI) group or coronary artery bypass grafting (CABG) group.

35 Background Over 180 000 coronary artery bypass grafting (CABG) procedures are pe

36 disease in place of the standard treatment, coronary artery bypass grafting (CABG).

37 tio, 0.68 [95% CI, 0.59-0.79]; P<0.0001) and coronary artery bypass grafting (hazard ratio, 0.61 [95%

38 y (1.85; 95% CI, 1.33-2.58) and lowest after coronary artery bypass grafting + mitral valve surgery (

39 s showed that a higher number of years since coronary artery bypass grafting and >1 target saphenous

40 oderate and 174 (1.87%) TIMI major/minor non-coronary artery bypass grafting bleeding events occurred

41 ly enrolled 113 patients undergoing elective coronary artery bypass grafting for cross-sectional stud

42 ostoperative atrial fibrillation (pAF) after coronary artery bypass grafting is a common complication

43 us Vein Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting Surgery) investigated wh

44 eficiaries who underwent elective colectomy, coronary artery bypass grafting, abdominal aortic aneury

45 cohort study included patients who underwent coronary artery bypass grafting, and/or aortic, mitral o

46 er 30, 2018: total knee or hip arthroplasty, coronary artery bypass grafting, colectomy, ventral hern

47 their performance to predict adjudicated non-coronary artery bypass grafting-related GUSTO (Global Us

48 eous coronary intervention and >10 times for coronary artery bypass grafting.

49 vein (LSV) is commonly used as a conduit in coronary artery bypass grafting.

50 hes), and EXCEL (Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left

51 the SYNTAX (TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narr

52 YNTAX Study: TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narr

53 dial infarction without procedure] to 55.3% [coronary artery bypass surgery only]).

54 Patients without AF undergoing coronary artery bypass surgery were recruited.

55 acute myocardial infarction hospitalization; coronary artery bypass surgery; heart valve repair/repla

56 ate analysis identified donor age >40 years, coronary artery bypass, and no aspirin after LT as indep

57 d as a novel marker for atherosclerosis, and coronary artery calcification (CAC) progression accordin

58 alcification can be a suitable predictor for coronary artery calcification and is a valid method for

59 extent, defined by a combined metric of the coronary artery calcification score and 2-dimensional va

60 king and treatment of athletes with elevated coronary artery calcification scores.

61 ardiac maladaptations, including accelerated coronary artery calcification, exercise-induced cardiac

62 ly increased with EAT volume >=113 cm(3) and coronary artery calcium >=100 AU and was highest in subj

63 e present study aimed to assess the value of coronary artery calcium (CAC) for guiding aspirin alloca

64 Coronary artery calcium (CAC) predicts atherosclerotic c

65 gh-sensitivity cardiac troponin (hs-cTn) and coronary artery calcium (CAC) scores of zero are associa

66 ced CT examinations that included the heart: coronary artery calcium (CAC) scoring CT, diagnostic CT

67 a prospective study of disease burden using coronary artery calcium (CAC) scoring, coronary CT angio

68 The use of coronary artery calcium (CAC) to predict risk of major a

69 Obesity is associated with higher risk for coronary artery calcium (CAC), but the relationship betw

70 atherosclerotic plaque burden as assessed by coronary artery calcium (CAC).

71 significantly attenuated the progression of coronary artery calcium and aortic valve calcification i

72 ing Research) with long-term follow-up after coronary artery calcium measurement.

73 .5% [4.8-9.2] versus 4.1% [0-6.8]; P<0.001), coronary artery calcium score (336 [62-1064] versus 19 [

74 ntify carotid and femoral plaque volume; and coronary artery calcium score (CACS) at baseline and 2.8

75 (CAC) progression according to the baseline coronary artery calcium score (CACS).

76 and symptoms) with clinical risk factors and coronary artery calcium score (CACS).

77 risk score (r=0.34; P<0.001), strongly with coronary artery calcium score (r=0.62; P<0.001), and ver

78 EAT measures were compared to coronary artery calcium score and atherosclerotic cardio

79 Herein, we review the use of the coronary artery calcium score as a decision aid in indiv

80 o vessel volume), cardiovascular risk score, coronary artery calcium score or obstructive coronary ar

81 , irrespective of cardiovascular risk score, coronary artery calcium score, or coronary artery area s

82 y assessed using cardiovascular risk scores, coronary artery calcium score, or coronary artery stenos

83 Coronary artery calcium scoring only represents a small

84 olled phase 2b trial compared progression of coronary artery calcium volume score and other measureme

85 The primary end point was change in log coronary artery calcium volume score from baseline to we

86 The mean change in coronary artery calcium volume score was 11% (95% CI, 7-

87 Also coronary artery computed tomography was carried out excl

88 hy, with at least 50% stenosis in at least 1 coronary artery considered significant.

89 ly 1 case in the MIS-C group (4%) manifested coronary artery dilatation (z score = 3.15) in the acute

90 Eight patients (14%) developed coronary artery dilatation or aneurysm.

91 rdiac arrhythmias, pericardial effusion, and coronary artery dilatation.

92 e common, including ventricular dysfunction, coronary artery dilation and aneurysms, arrhythmia, and

93 95% confidence interval [CI], 1.60 to 2.41), coronary artery disease (10.2%, vs. 5.2% among those wit

94 quency of 1-vessel disease or nonobstructive coronary artery disease (39.6% versus 29.1%, P<0.0001).

95 The most common cause of SCD was coronary artery disease (40%), followed by sudden arrhyt

96 s; P<0.001), and the presence of obstructive coronary artery disease (54% versus 25%; P<0.001) were a

97 ardiologists have long treated patients with coronary artery disease (CAD) and concomitant type 2 dia

98 Because rates of coronary artery disease (CAD) are substantially higher a

99 ic structure that contributes to the risk of coronary artery disease (CAD) can be evaluated as a risk

100 Coronary artery disease (CAD) causes mortality and morbi

101 Coronary artery disease (CAD) events have been associate

102 TL) shortens with age and is associated with coronary artery disease (CAD) events in the general popu

103 Medicare patients with coronary artery disease (CAD) have been a significant fo

104 Polygenic risk scores (PRS) for coronary artery disease (CAD) identify high-risk individ

105 ndicate high polygenic risk scores (PRS) for coronary artery disease (CAD) identify individuals at hi

106 graphy demonstrated agreement in severity of coronary artery disease (CAD) in 52% (82 of 159) of all

107 e circRNA hsa_circ_0001445 as a biomarker of coronary artery disease (CAD) in a real-world clinical p

108 Applied to coronary artery disease (CAD) in both the WGHS and in JU

109 Coronary artery disease (CAD) is a major cause of morbid

110 Coronary artery disease (CAD) is more frequent among ind

111 eillance in symptomatic patients with stable coronary artery disease (CAD) is unknown.

112 investigate functional mechanisms underlying coronary artery disease (CAD) loci and find molecular bi

113 Regulatory SNPs identified were enriched in coronary artery disease (CAD) loci, and this result has

114 diagnosis factors for assessing the risks of coronary artery disease (CAD) remains controversial.

115 epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the funct

116 in identification of genomic loci affecting coronary artery disease (CAD) risk.

117 ts into the BDNF mediated pathophysiology in coronary artery disease (CAD) that may shed light upon p

118 Evaluation of coronary artery disease (CAD) using coronary computed to

119 in the circulation of patients with unstable coronary artery disease (CAD), and their recruitment to

120 ch demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or r

121 In other forms of coronary artery disease (CAD), however, it has been cont

122 erved to improve the health of patients with coronary artery disease (CAD).

123 (TPOT) to predict angiographic diagnoses of coronary artery disease (CAD).

124 rdiac surgery, particularly in patients with coronary artery disease (CAD).

125 event are often referred to as having stable coronary artery disease (CAD).

126 d to estimate the potential causal effect on coronary artery disease (CAD).

127 idemia is a highly heritable risk factor for coronary artery disease (CAD).

128 y individuals with elevated lifetime risk of coronary artery disease (CAD).

129 variables for inferring risk factors causing coronary artery disease (CAD).

130 95% confidence interval [CI]: 1.37 to 3.76), coronary artery disease (HR: 1.89; 95% CI: 1.26 to 2.82)

131 Patients with angiographically verified coronary artery disease (n=1946) underwent a clinical ev

132 Fourteen percent of patients had preexisting coronary artery disease (n=31), 33% arterial hypertensio

133 on clinical read and no known macrovascular coronary artery disease (n=783), MPR remained independen

134 s ratio, 4.22 [95% CI, 1.71-10.4], P=0.002), coronary artery disease (odds ratio, 0.35 [95% CI, 0.16-

135 nfidence interval (CI), 1.2-3.4, P = 0.009), coronary artery disease (OR, 1.9; 95% CI, 1.1-3.7; P = 0

136 32 145 patients: 14 095 (43.8%) with stable coronary artery disease and 18 046 (56.1%) with acute co

137 Patients with preexisting diagnoses of coronary artery disease and arrhythmia had the highest l

138 icantly increased in cardiovascular disease (coronary artery disease and heart failure) after adjustm

139 l infarction (MI) is common in patients with coronary artery disease and is associated with high mort

140 In conclusion, prediabetes likely causes coronary artery disease and its prevention is likely to

141 3.02]) and (2) lower risk of atherosclerotic coronary artery disease and MI in the UK Biobank (P = 1.

142 PRSs for coronary artery disease and years of education were sign

143 iagnosis and PRP) and medical comorbidities (coronary artery disease and/or myocardial infarction, he

144 dial infarction in patients with established coronary artery disease are lacking.

145 y revascularization (HCR) treats multivessel coronary artery disease by combining a minimally invasiv

146 sion of NBEAL1 may lead to increased risk of coronary artery disease by downregulation of LDLR levels

147 to medical therapy for patients with stable coronary artery disease continues to be debated in routi

148 rong causal association of lipoprotein(a) in coronary artery disease development (beta, -0.13; per SD

149 hy angiography increases the sensitivity for coronary artery disease diagnoses compared with function

150 We included 13 patients with coronary artery disease due to severe atherosclerosis an

151 efforts and dynamic research in the field of coronary artery disease genetic risk prediction.

152 insic sex difference in ECs are enriched for coronary artery disease GWAS hits.

153 Clinical studies using DCB in de novo coronary artery disease have shown mixed results, with a

154 Comorbidities included hypertension in 61%, coronary artery disease in 25%, ventricular arrhythmia h

155 The poorer prognosis of coronary artery disease in females compared with males i

156 revascularisation of patients with left main coronary artery disease in place of the standard treatme

157 of genome-wide association study signals for coronary artery disease in RA signaling target gene loci

158 cardial ischaemia resulting from obstructive coronary artery disease is a major cause of morbidity an

159 Coronary artery disease is common in patients with sever

160 Coronary artery disease is the main cause of burden of d

161 ) who presented with ACS and had evidence of coronary artery disease on coronary angiography managed

162 Epidemiology Atrial Fibrillation), C(2)HEST (coronary artery disease or chronic obstructive pulmonary

163 nt in many patients with complex multivessel coronary artery disease or left main disease.

164 Patients with established coronary artery disease or peripheral artery disease oft

165 ith education but is not strongly causal for coronary artery disease or type 2 diabetes.

166 nd the risk of sudden cardiac death (SCD) in coronary artery disease patients is not well known.

167 e modest than, the degree of protection from coronary artery disease predicted by these same methods

168 i-tissue gene expression associations to key coronary artery disease processes and clinical phenotype

169 litus and hypertension to slow and stabilize coronary artery disease progression and improve clinical

170 ients with de novo 3-vessel and/or left main coronary artery disease randomized to treatment with PCI

171 dy of patients with both suspected and known coronary artery disease referred clinically for perfusio

172 Patients with left main coronary artery disease requiring revascularisation were

173 ing target gene loci and correlation between coronary artery disease risk alleles and repressed expre

174 In the Coronary Artery Disease Risk Development in Young Adults

175 ular development, and has been implicated in coronary artery disease risk.

176 d phenotypic modulation of this cell type in coronary artery disease risk.

177 acute myocardial infarction and multivessel coronary artery disease should not be treated differentl

178 y angiography (CTCA) performed for suspected coronary artery disease to undergo a repeat research CTC

179 wer-risk patients who may eventually require coronary artery disease treatment.

180 population-based cohort study of adults with coronary artery disease undergoing single-vessel FFR ass

181 Patients with known coronary artery disease underwent (18)F-NaF PET computed

182 Participants with stable coronary artery disease underwent acute mental stress te

183 Patients with angina and nonobstructive coronary artery disease underwent simultaneous acquisiti

184 Background Progression of coronary artery disease using serial coronary computed t

185 utility of polygenic risk scores to stratify coronary artery disease was also assessed.

186 the use of paclitaxel DCBs for treatment of coronary artery disease was not associated with increase

187 , ST-segment elevation, and absence of known coronary artery disease were independent predictors of u

188 ents with de-novo three-vessel and left main coronary artery disease were randomly assigned (1:1) to

189 acute myocardial infarction and multivessel coronary artery disease were randomly assigned to one of

190 Among patients with coronary artery disease who underwent single-vessel FFR

191 In patients with established coronary artery disease, (18)F-NaF PET provides powerful

192 e by age 75 years ranged from 17% to 78% for coronary artery disease, 13% to 76% for breast cancer, a

193 , p <0.05) included end-stage renal disease, coronary artery disease, and neurologic disorders, but n

194 Risk factors include tobacco use, coronary artery disease, and respiratory failure.

195 onic conditions were included: hypertension, coronary artery disease, arthritis, chronic kidney disea

196 Cardiovascular disease (CVD), including coronary artery disease, atrial fibrillation, and heart

197 For the prediction of coronary artery disease, boosting algorithms had a poole

198 That coronary artery disease, but not chronic lung disease, w

199 nic kidney disease without overt obstructive coronary artery disease, but the mechanisms remain poorl

200 mplicate the care of patients with suspected coronary artery disease, but their prevalence and impact

201 In diabetic patients with multivessel coronary artery disease, CABG was associated with a lowe

202 estations of cardiovascular disease, such as coronary artery disease, cerebrovascular disease and per

203 f the predictive ability of ML algorithms of coronary artery disease, heart failure, stroke, and card

204 In the absence of obstructive coronary artery disease, intravascular imaging technique

205 has been shown that in patients with chronic coronary artery disease, ischemic episodes lead to a glo

206 icism is associated with the genetic risk of coronary artery disease, lower intelligence, lower socio

207 ions with depression and insomnia as well as coronary artery disease, mirroring findings from epidemi

208 bowel disease, psoriasis, Sjogren syndrome, coronary artery disease, multiple sclerosis, cystic fibr

209 CYP17A1 genetic variants are associated with coronary artery disease, myocardial infarction and visce

210 therapy is secondary prevention, concomitant coronary artery disease, particularly with prior myocard

211 In the absence of epicardial coronary artery disease, patients with heart transplants

212 In revascularisation of left main coronary artery disease, PCI was associated with an infe

213 Among patients with coronary artery disease, statin medication rates increas

214 investigating the effects of prediabetes in coronary artery disease, stroke and chronic kidney disea

215 mong patients with angina and nonobstructive coronary artery disease, those with coronary microvascul

216 to improve clinical outcomes in multivessel coronary artery disease, though its impact in diabetic p

217 ntal value of polygenic risk score (PRS) for coronary artery disease, we added the score to 3 models

218 n diet reduces the incidence and severity of coronary artery disease, whereas supplementation with ni

219 at prediabetes is only causally related with coronary artery disease, with no evidence of causal effe

220 erotic cardiovascular disease-in particular, coronary artery disease-and its contribution to disease

221 anisms, further establishing a role for this coronary artery disease-associated gene in fundamental S

222 Residential remoteness was associated with coronary artery disease-related SCD (odds ratio, 1.44 [9

223 or the treatment of hypercholesterolemia and coronary artery disease.

224 n myocardial infarction (MI) and multivessel coronary artery disease.

225 ty, such as hypertension, hyperlipidemia, or coronary artery disease.

226 s correlates with angina in individuals with coronary artery disease.

227 n the workup of patients suspected of having coronary artery disease.

228 cardiovascular events in those without overt coronary artery disease.

229 chemic cause in patients with nonobstructive coronary artery disease.

230 iovascular events (MACE) in individuals with coronary artery disease.

231 in values, and have more severe angiographic coronary artery disease.

232 ic instability in the absence of obstructive coronary artery disease.

233 t ischemic attack, age >=75, and no previous coronary artery disease.

234 the risk of SCD and non-SCD in patients with coronary artery disease.

235 in patients with subclinical, nonobstructive coronary artery disease.

236 tment strategy for patients with symptomatic coronary artery disease.

237 ification in patients with clinically stable coronary artery disease.

238 nary disease, interstitial lung disease, and coronary artery disease.

239 cholesterol levels and hence development of coronary artery disease.

240 ted in female and male patients with complex coronary artery disease.

241 traditional risk factors of atherosclerotic coronary artery disease.

242 -related biomarkers with type 2 diabetes and coronary artery disease.

243 rtality at 10 years in patients with complex coronary artery disease.

244 n humans, TCF21 expression inhibits risk for coronary artery disease.

245 rely performed for patients with multivessel coronary artery disease.

246 larisation strategy in patients with complex coronary artery disease.

247 ray of applications beyond the assessment of coronary artery disease.

248 d atheroprotective marker, in particular for coronary artery disease; however, HDL particle concentra

249 Over the past decade, spontaneous coronary artery dissection (SCAD) has emerged as an impo

250 Spontaneous coronary artery dissection (SCAD) is a non-atherosclerot

251 lerotic causes of ACS, including spontaneous coronary artery dissection, coronary artery embolism, va

252 cular mechanisms underlying the formation of coronary arteries during development and during cardiac

253 ding spontaneous coronary artery dissection, coronary artery embolism, vasospasm, myocardial bridging

254 g of coronary vessels, resulting in improper coronary artery formation.

255 ile its genetic deletion leads to inadequate coronary artery formation.

256 is, histological analysis of skin wounds and coronary arteries from AD-HIES patients showed decreased

257 Monocyte recruitment to inflamed coronary arteries is initiated by high affinity beta2-in

258 Intraseptal anomalous aortic origin of a coronary artery is considered a benign condition.

259 ent sham surgery or left anterior descending coronary artery ligation at age P1 or P7.

260 thods: Male C57BL/6 mice underwent permanent coronary artery ligation followed by (11)C-methionine PE

261 Coronary artery ligation surgery was performed in male S

262 9) underwent left anterior descending (LAD) coronary artery ligation to mimic vulnerable atheroscler

263 underwent permanent left anterior descending coronary artery ligation which, 8-10 weeks later, led to

264 man samples, murine left anterior descending coronary artery ligation, and adeno-associated virus 9-m

265 -expressing mice were subjected to permanent coronary artery ligation, then treated briefly with DMB.

266 Unlike classic KD, coronary arteries may be spared in early MIS-C; however,

267 Myocardial infarction with nonobstructive coronary arteries (MINOCA) occurs in 6% to 15% of myocar

268 ated with transcatheter interventions in the coronary arteries, moderate-to-severe calcification port

269 olymer Stent System for Revascularization of Coronary Arteries; n=1398) is a prospective, multicenter

270 ramagnetic shift associated with duration of coronary artery occlusion and the presence of iron.

271 mmon, occurring even in the absence of acute coronary artery occlusion, and contributes to high rates

272 was correlated with desmosine (p<0.001), and coronary artery (p=0.002) and thoracic aortic (p<0.001)

273 dent by the re-expression of fetal genes and coronary artery perivascular fibrosis, with ischaemia in

274 L) is associated with the presence of EBV in coronary artery plaque samples in the current study.

275 s defined as intervention of a 100% occluded coronary artery presumed to be >=3 months old.

276 Acute occlusion of a coronary artery results in swift tissue necrosis.

277 prevention and medical therapy, the role of coronary artery revascularization has decreased and is l

278 This study analyzed data from the CARDIA (Coronary Artery Risk Development in Young Adults Study).

279 e expression levels and lung function in the Coronary Artery Risk Development in Young Adults study.

280 Using CARDIA (Coronary Artery Risk Development in Young Adults) study

281 uded 191 participants from the CARDIA study (Coronary Artery Risk Development in Young Adults), a com

282 Herein, using human coronary artery sections with a bare metal stent, we dem

283 dence time (Blood(RT)), was computed for 100 coronary artery segments for which FFR was known.

284 O (Global Use of Strategies to Open Occluded Coronary Arteries) severe/life-threatening/moderate and

285 y SMCs revealed that AHR modulates the human coronary artery SMC phenotype and suppresses ossificatio

286 sequencing to map SRF-binding sites in human coronary artery SMC, showing that binding is colocalized

287 led with functional assays in cultured human coronary artery SMCs revealed that AHR modulates the hum

288 s confirmed experimentally by treating human coronary artery smooth muscle cells in an in vitro calci

289 In this ex vivo imaging study of coronary artery specimens, the non-invasive imaging radi

290 coronary artery calcium score or obstructive coronary artery stenoses.

291 phy angiography (CTA) may be used to exclude coronary artery stenosis >=50% in patients with NSTEACS.

292 was the ability of coronary CTA to rule out coronary artery stenosis (>=50% stenosis) in the entire

293 Coronary artery stenosis is a narrowing of coronary lume

294 sk scores, coronary artery calcium score, or coronary artery stenosis severity.

295 ype of acute myocardial infarction, affected coronary artery territory, and baseline left ventricular

296 Changes in coronary artery, thoracic aorta, and cardiac valve calci

297 luzole died from ischaemic heart disease and coronary artery thrombosis, and one patient assigned flu

298 nscriptional cis-regulation in primary human coronary artery vascular smooth muscle cells (HCASMCs).

299 e rejection (>1 y) have been associated with coronary artery vasculopathy (CAV) in pediatric heart tr

300 erved irrespective of which major epicardial coronary artery was treated.