ライフサイエンスコーパス: coronary flow reserve

1 esponse to hyperemic stimuli (i.e., abnormal coronary flow reserve).

2 information can be deduced by measuring the coronary flow reserve.

3 nd attenuated endothelial and nonendothelial coronary flow reserve.

4 helial-dependent and endothelial-independent coronary flow reserve.

5 ardial perfusion reserve matches the reduced coronary flow reserve.

6 cardial layers and vary in relation to local coronary flow reserve.

7 es were previously considered to have normal coronary flow reserve.

8 her pulmonary vascular resistance, and lower coronary flow reserve.

9 function assessment based on the endothelial coronary flow reserve.

10 to quantify resting MBF, hyperemic MBF, and coronary flow reserve.

11 roved pressure-only estimation of underlying coronary flow reserve.

12 flow can also lead to accurate assessment of coronary flow reserve.

13 graphy to quantify myocardial blood flow and coronary flow reserve.

14 including a stress total severity score and coronary flow reserve.

15 her compared with that for hyperemic MBF and coronary flow reserve (0.76; P=0.32 and 0.72; P=0.08, re

16 mL.min(-1).g(-1), respectively; P=0.40) and coronary flow reserve (1.34+/-1.08, 1.14+/-1.09, 1.31+/-

17 us 1.66+/-0.38 mL.min(-1).g(-1); P<0.01) and coronary flow reserve (1.59+/-0.49 versus 2.12+/-0.48; P

18 low (140 versus 191 mL/min; P=0.0165), lower coronary flow reserve (1.82 versus 3.21; P<=0.0001), and

19 ith abnormal coronary microcirculation (mean coronary flow reserve = 1.84), adenosine increased coron

20 ), %untwMVO (31% versus 27% versus 17%), and coronary flow reserve (14% versus 11% versus 4%), as wel

21 nary flow (196 versus 192 mL/min; P=0.8292), coronary flow reserve (2.77 versus 3.21; P=0.1107), and

22 sus 1.78+/-0.43 mL/min per gram; P=0.01) and coronary flow reserve (2.78+/-0.32 versus 2.01+/-0.52; P

23 degrees ), %untwMVO (27.8% versus 35%), and coronary flow reserve (2.8 versus 3.1) and reduced circu

24 control groups (median [interquartile range] coronary flow reserve, 2.9 [2.5-3.4] versus 3.0 [2.4-3.4

25 using speckle-tracking echocardiography, (2) coronary flow reserve, (3) pulse wave velocity and augme

26 -mediated dilation (57+/-4% versus 47+/-5%), coronary flow reserve (37+/-4% versus 29+/-2%), arterial

27 ronary microvascular dysfunction measured by coronary flow reserve 8 to 10 years after delivery and w

28 without obstructive coronary artery disease, coronary flow reserve (abnormal <2.0), index of microvas

29 All patients had coronary flow reserve abnormalities and subsequently dev

30 n present as angina pectoris associated with coronary flow reserve abnormalities despite normal coron

31 Doppler-derived coronary flow reserve accurately predicts the presence o

32 ought to examine the mechanism of increasing coronary flow reserve after balloon angioplasty and sten

33 positron emission tomography to measure the coronary flow reserve, an integrated measure of coronary

34 icant correlation between MRI assessments of coronary flow reserve and (a) assessments of coronary ar

35 Coronary flow reserve and coronary blood flow were obtai

36 or eliminated with measurements of relative coronary flow reserve and fractional flow reserve.

37 The association of coronary flow reserve and HDP was attenuated after adjus

38 modilution measures of flow to determine the coronary flow reserve and measures of microvascular resi

39 agnostic coronary angiography, assessment of coronary flow reserve and microcirculatory resistance, p

40 Coronary flow reserve and microvascular resistance reser

41 ll conducting vessel densities and increased coronary flow reserve and perfusion-dependent cardiac co

42 emodynamic endotypes were assessed measuring coronary flow reserve and resistance using an intracoron

43 d nonendothelial microvascular function with coronary flow reserve and the index of microvascular res

44 Secondary end points included changes in coronary flow reserve and the resistive resistance ratio

45 duced vasodilatation with exercise = reduced coronary flow reserve and/or vasospasm at rest) might al

46 blood flow, hyperemic myocardial blood flow, coronary flow reserve, and CFC are prognostic factors fo

47 herence tomography, fractional flow reserve, coronary flow reserve, and index of microcirculatory res

48 rovascular resistance, myocardial perfusion, coronary flow reserve, and microvascular resistance rese

49 Recovery of hyperemic MBF, coronary flow reserve, and perfusion defect size after C

50 Changes in hyperemic MBF, coronary flow reserve, and perfusion defect size were co

51 The index of microcirculatory resistance, coronary flow reserve, and resistive reserve ratio were

52 Hyperemic MBF, coronary flow reserve, and RFR were lower for vessels wi

53 yocardial perfusion grade, TIMI frame count, coronary flow reserve, and ST-segment resolution were al

54 Fractional flow reserve, coronary flow reserve, and the index of microcirculatory

55 absolute coronary flow reserve, the relative coronary flow reserve, and the pressure-derived fraction

56 Efficacy measures included coronary flow reserve, angina frequency, Canadian Cardio

57 4; 95% confidence intervals [0.69-0.99]) and coronary flow reserve (area under the curve, 0.77; 95% c

58 ndergoing invasive pressure wire studies and coronary flow reserve assessment.

59 Coronary flow reserve at base line was lower in the sten

60 Measurement of coronary flow reserve can be used to identify functional

61 Coronary flow reserve cannot be measured merely with pre

62 of an IMR>40, alone or in combination with a coronary flow reserve (CFR</=2.0), in the culprit artery

63 ients with metabolic syndrome showed a lower coronary flow reserve (CFR) (2.5 +/- 1.0) than those wit

64 Enalaprilat also restored subendocardial coronary flow reserve (CFR) (baseline CFR, 1.89+/-0.11;

65 between major adverse outcomes and baseline coronary flow reserve (CFR) after intracoronary adenosin

66 ediate stenoses were classified in 4 FFR and coronary flow reserve (CFR) agreement groups, using FFR>

67 We hypothesized that the measurement of coronary flow reserve (CFR) allows identification of pat

68 the hypothesis that increased variability of coronary flow reserve (CFR) among multiple vascular regi

69 optimal cutoffs of hyperemic MBF (hMBF) and coronary flow reserve (CFR) and evaluated whether cutoff

70 ction can be distinctly quantified using the coronary flow reserve (CFR) and index of microvascular r

71 tial advantages over current methods such as coronary flow reserve (CFR) and index of microvascular r

72 Measurements of Doppler derived coronary flow reserve (CFR) and pressure derived fractio

73 oronary thermodilution techniques to measure coronary flow reserve (CFR) and the index of microcircul

74 The invasive microvascular function indices, coronary flow reserve (CFR) and the index of microcircul

75 rements of fractional flow reserve (FFR) and coronary flow reserve (CFR) and the index of microcircul

76 We assessed coronary flow reserve (CFR) as a marker of coronary micr

77 Measuring coronary flow reserve (CFR) as well as FFR could add inf

78 In a cross-sectional design, coronary flow reserve (CFR) assessed by cardiac (82)Rb-p

79 The goal of this study was to assess coronary flow reserve (CFR) before and after aortic valv

80 idated for absolute myocardial perfusion and coronary flow reserve (CFR) by positron emission tomogra

81 In its general form, MRR equals coronary flow reserve (CFR) divided by fractional flow r

82 MRR was derived as a function of the coronary flow reserve (CFR) divided by the fractional fl

83 ex of microcirculatory resistance (IMR), and coronary flow reserve (CFR) for predicting microvascular

84 The purpose of this study was to compare coronary flow reserve (CFR) in a group of premenopausal

85 isoforms on myocardial blood flow (MBF) and coronary flow reserve (CFR) in volunteers and in (denerv

86 and B had a normal coronary angiogram and a coronary flow reserve (CFR) of > or =2.5 (CFR = hyperemi

87 and coronary microvascular dysfunction as a coronary flow reserve (CFR) of less than 2.0.

88 ts were (1) myocardial perfusion assessed by coronary flow reserve (CFR) on cardiac PET or stress myo

89 Stress myocardial perfusion (mL/min/g) and coronary flow reserve (CFR) per pixel were quantified in

90 Coronary flow reserve (CFR) was 1.48 +/- 0.34 and 2.08 +

91 Abnormal coronary flow reserve (CFR) was associated with a higher

92 Coronary flow reserve (CFR) was determined from positron

93 ex of microcirculatory resistance (IMR), and coronary flow reserve (CFR) was performed in 254 patient

94 iastolic/systolic velocity ratio (DSVR), and coronary flow reserve (CFR) were assessed before interve

95 cardial blood flow (MBF), hyperemic MBF, and coronary flow reserve (CFR) were compared among 4 groups

96 is a new technique for invasively measuring coronary flow reserve (CFR) with a coronary pressure wir

97 d to validate the technique of measuring the coronary flow reserve (CFR) with coronary pressure measu

98 ntitation of myocardial blood flow (MBF) and coronary flow reserve (CFR) with dynamic (82)Rb PET is f

99 We tested the hypothesis that a normal coronary flow reserve (CFR) would be helpful for excludi

100 Coronary flow reserve (CFR), a marker of coronary microv

101 Reduced coronary flow reserve (CFR), an indicator of coronary mi

102 en low-level troponin elevation and impaired coronary flow reserve (CFR), an integrated measure of co

103 Coronary flow reserve (CFR), an integrated measure of fo

104 Coronary flow reserve (CFR), an integrated measure of la

105 FR), (2) Doppler wire-derived measurement of coronary flow reserve (CFR), and (3) intravascular ultra

106 Yet, coronary flow reserve (CFR), despite being widely used t

107 Paired fractional flow reserve (FFR), coronary flow reserve (CFR), index of microcirculatory r

108 his study sought to examine the evolution of coronary flow reserve (CFR), index of microcirculatory r

109 lar disease (CMD), characterized by impaired coronary flow reserve (CFR), is a common finding in pati

110 n of maximal myocardial blood flow (MBF) and coronary flow reserve (CFR), termed coronary flow capaci

111 Impaired coronary flow reserve (CFR), the ratio of adenosine-stim

112 th true microvascular resistance and, unlike coronary flow reserve (CFR), to be independent of the ep

113 k index (GWI), wasted myocardial work (GWW), coronary flow reserve (CFR), total arterial compliance (

114 relation between habitual dietary sodium and coronary flow reserve (CFR), which is a measure of overa

115 on, as assessed by quantitative estimates of coronary flow reserve (CFR), with respect to prediction

116 fractional flow reserve (FFR) but preserved coronary flow reserve (CFR).

117 compare the accuracy of hyperemic MBF versus coronary flow reserve (CFR).

118 emission tomography (PET) and assessment of coronary flow reserve (CFR).

119 ification of myocardial blood flow (MBF) and coronary flow reserve (CFR).

120 11 nondiabetics) underwent quantification of coronary flow reserve (CFR; CFR=stress divided by rest m

121 myocardial blood flow (MBF) and the relative coronary flow reserves (CFR) using (15)O-labeled water (

122 Thermodilution coronary flow reserve (CFRthermo) is a new technique for

123 tructive coronary artery disease, diminished coronary flow reserve characterizes a cohort with induci

124 ous coronary intervention, it disagrees with coronary flow reserve classification 30% of the time.

125 is more accurate for assessment of impaired coronary flow reserve compared with SPECT MPI, potential

126 e contrast-derived indices (contrast-derived coronary flow reserve, contrast-derived index of microci

127 tment kinetic model and were used to compute coronary flow reserve (coronary flow reserve equals stre

128 Noninvasive MRI measures of coronary flow reserve correlated well with similar measu

129 othesis that an acute critical limitation in coronary flow reserve could rapidly recapitulate the phy

130 Coronary flow reserve decreased after a single high-fat

131 In the 5 men who received both meals, mean coronary flow reserve decreased by 0.79 after the high-f

132 As coronary flow reserve decreases, fasting FDG uptake incr

133 sive fractional flow reserve and noninvasive coronary flow reserve, depends on their ability to impro

134 ow-mediated dilation of brachial artery; (2) coronary flow reserve, ejection fraction, systemic arter

135 were used to compute coronary flow reserve (coronary flow reserve equals stress divided by rest myoc

136 f coronary flow reserve <2.5 and controls if coronary flow reserve >=2.5, with researchers blinded to

137 ith normal coronary flow reserve (reference: coronary flow reserve, >=2.5).

138 Doppler wire-derived coronary flow reserve has been applied in research studi

139 Coronary flow reserve has extensive validation as a prog

140 the ratio of hyperemic to resting velocity (coronary flow reserve), have been more commonly studied.

141 [95% CI, 0.52-0.90]; P=0.007) and decreased coronary flow reserve (HR, 0.55 [95% CI, 0.42-0.71]; P<0

142 Coronary flow reserve improved from 2.08+/-0.32 at basel

143 The ratio of coronary flow reserve in coronary arteries with stenosis

144 groups, reflecting the greater diminution in coronary flow reserve in group 2 dogs (LAD/LCx flow rati

145 imaging provided reproducible assessment of coronary flow reserve in humans.

146 the microvascular (endothelium-independent) coronary flow reserve in response to intracoronary adeno

147 microcirculatory responsiveness and impaired coronary flow reserve in smokers, which provides evidenc

148 er and thus may be well suited for assessing coronary flow reserve in the acute phase of reperfusion.

149 Interestingly, coronary flow reserve in the reperfused zone of group 1

150 intended to identify regional limitations in coronary flow reserve in viable myocardium need to ident

151 Coronary flow reserve increased from 2.46+/-1.52 to 4.20

152 Coronary flow reserve increases after AVR for aortic ste

153 Coronary flow reserve, index of microvascular resistance

154 giography with guidewire-based assessment of coronary flow reserve, index of microvascular resistance

155 e ischemia in an area of chronically reduced coronary flow reserve induces regional myocyte loss via

156 Incorporation of coronary flow reserve into cardiac death risk assessment

157 ent of maximal saline- and adenosine-induced coronary flow reserve (intraclass correlation coefficien

158 Coronary flow reserve is impaired under conditions of le

159 ubmaximal increases in cardiac workload when coronary flow reserve is limited.

160 ry infusion of CD34+ cell therapy had higher coronary flow reserve, less severe angina, and better qu

161 , the regional perfusion reserve matched the coronary flow reserve (linear regression with a slope of

162 Coronary flow reserve, lipid levels, and hemodynamic cha

163 A coronary flow reserve < 1.7 predicted the presence of a

164 aracterized as having impaired post-stenotic coronary flow reserve < 2.0 and pressure-derived fractio

165 ascular endothelial dysfunction (endothelial coronary flow reserve <1.5) was observed in 44%.

166 the patients; fractional flow reserve <=0.8, coronary flow reserve <2, and index of microvascular res

167 Contrast-derived coronary flow reserve <2.0 (area under the curve 0.81; s

168 Endothelium-independent CMD (ie, coronary flow reserve <2.0 and/or index of microvascular

169 Coronary flow reserve was quantified, and coronary flow reserve <2.0 was used to define the presen

170 o detect abnormal adenosine-derived indices (coronary flow reserve <2.0, index of microvascular resis

171 A coronary flow reserve <2.00 was seen in 18 patients (51%

172 als with coronary microvascular dysfunction (coronary flow reserve <2.0; n=13) had a higher proportio

173 Patients were classified as having MVD if coronary flow reserve <2.5 and controls if coronary flow

174 osine-mediated vasodilation was defined as a coronary flow reserve <2.5 and/or hyperemic microvascula

175 Among patients with a coronary flow reserve <2.5, 62% had functional MVD, with

176 intracoronary thermodilution and defined as coronary flow reserve <2.5.

177 verely reduced coronary flow capacity (CFC) (coronary flow reserve <= 1.27 and stress perfusion <= 0.

178 ry artery disease with persistent angina and coronary flow reserve <=2.5.

179 The lowest tertile of coronary flow reserve (<1.5) was associated with a 5.6-f

180 1 with coronary microvascular disease (CMD: coronary flow reserve, <2.5) and 1 with normal coronary

181 MRI-based measurement of coronary flow reserve may prove useful for identificatio

182 al change (17.3% versus 17.09%; P=0.91), and coronary flow reserve measurements (2.63 versus 2.53; P=

183 cluding 3-vessel fractional flow reserve and coronary flow reserve measurements.

184 dure with reference invasive tests including coronary flow reserve, microvascular resistance, and vas

185 flow (IDV) (mL/min)+17 (mL/min), r=.89, and coronary flow reserve (MRI) =0.79 x coronary velocity re

186 n humans with impaired endothelium-dependent coronary flow reserve of the coronary epicardial and mic

187 o between-group differences in post-PCI FFR, coronary flow reserve, or corrected index of microcircul

188 0.0369), compared with moderate or mild CFC, coronary flow reserve, other PET metrics or medical trea

189 ending coronary artery to chronically reduce coronary flow reserve over a period of 3 months.

190 angiography and (b) invasive measurements of coronary flow reserve (P<0.0001 for both).

191 ence interval, 0.75-086] per 10% increase in coronary flow reserve; P<0.0001) and resulted in favorab

192 canine myocardial infarction model with some coronary flow reserve preservation, 99mTc-N-NOET imaging

193 MR-QP, positron emission tomography, and ICA-coronary flow reserve (r<0.40 for all comparisons).

194 s evident when angiography was compared with coronary flow reserve (r=.43), and the angiogram did not

195 ronary flow reserve, <2.5) and 1 with normal coronary flow reserve (reference: coronary flow reserve,

196 Addition of coronary flow reserve resulted in correct reclassificati

197 eserve by both PET tracers compared with ICA coronary flow reserve (rho, 0.11-0.38).

198 yocardial infarction in relation to tests of coronary flow reserve; surveys the extensive literature

199 Coronary flow reserve, systolic and diastolic velocity t

200 varying degrees of vessel patency using any coronary flow reserve technique.

201 Patients with HCM had a lower coronary flow reserve than control subjects (1.9 +/- 0.8

202 luding angiography, fractional flow reserve, coronary flow reserve, the index of microcirculatory res

203 ude the measurement of poststenotic absolute coronary flow reserve, the relative coronary flow reserv

204 Coronary flow reserve, therefore, increased from 1.76+/-

205 reference group or as patients with CMD by a coronary flow reserve threshold of 2.5; functional or st

206 he prognostic value of IMR was compared with coronary flow reserve, TIMI myocardial perfusion grade,

207 tegrates hyperemic myocardial blood flow and coronary flow reserve to quantify the pathophysiological

208 A PC-MRI coronary flow reserve value </=2.0 was 100% and 82% sens

209 e ratio was 0.80 (0.48-0.89), and the median coronary flow reserve was 1.42 (1.08-1.85).

210 s 0.86+/-0.05, 0.92+/-0.04, and 0.94+/-0.05; coronary flow reserve was 2.5+/-0.5, 2.0+/-0.3, and 3.2+

211 Coronary flow reserve was 2.8+/-0.2 (mean+/-SEM) in cont

212 Average coronary flow reserve was 4.02 before and 3.30 5 hours a

213 Regardless of sex, coronary flow reserve was a powerful incremental predict

214 Low coronary flow reserve was a predictor of increased MACE

215 Coronary flow reserve was also decreased in the neuropat

216 Coronary flow reserve was also significantly higher in c

217 Coronary flow reserve was calculated as stress/rest myoc

218 Coronary flow reserve was calculated as the ratio of bet

219 nge of coronary artery diameter or change in coronary flow reserve was demonstrated.

220 Coronary flow reserve was determined by using transthora

221 Endothelium-independent coronary flow reserve was examined by use of intracorona

222 high-risk patients with ACS undergoing PCI, coronary flow reserve was greater with bivalirudin than

223 s significantly higher (+95%, p = 0.001) and coronary flow reserve was lower (-0.21, p = 0.02) in twi

224 In the patients, the coronary flow reserve was measured with an intracoronary

225 Coronary flow reserve was measured, and analyses were pe

226 The coronary flow reserve was not significantly different be

227 tional flow reserve and thermodilution-based coronary flow reserve was performed.

228 Coronary flow reserve was quantified, and coronary flow

229 At baseline, coronary flow reserve was reduced by 21% in smokers comp

230 (n = 754), the primary end point of post-PCI coronary flow reserve was significantly greater with biv

231 In Myocardial Infarction) flow grade 2, and coronary flow reserve were associated with LVEDP/IMR gro

232 this pilot study, impaired hyperemic MBF and coronary flow reserve were associated with VA inducibili

233 Adenosine and acetylcholine coronary flow reserve were calculated as vasodilator/res

234 sistance (IMR), fractional flow reserve, and coronary flow reserve were measured before stenting in t

235 asible, intracoronary Doppler assessments of coronary flow reserve, were performed.

236 Assessments of coronary flow reserve with PC-MRI can be used to identif

237 ation between endothelial and nonendothelial coronary flow reserve with vascular remodeling in patien

238 mild to moderate stenoses requires assessing coronary flow reserve with vasodilator stress.