ライフサイエンスコーパス: cortical neuron

1 Foxp2 is expressed in a subset of Layer VI cortical neurons.

2 or a broad range of synapses converging onto cortical neurons.

3 ned by targeting Rac1-dependent processes in cortical neurons.

4 learned complex sounds in a small subset of cortical neurons.

5 and morphology of EVs released from primary cortical neurons.

6 to account for trial-to-trial variability in cortical neurons.

7 apse maturation, traits characterizing human cortical neurons.

8 um-chloride co-transporter KCC2 in principal cortical neurons.

9 tory networks that directly interconnect all cortical neurons.

10 nic stem cells, neural progenitor cells, and cortical neurons.

11 ns that required dynamical interaction among cortical neurons.

12 lus preference as a stable characteristic of cortical neurons.

13 he mouse and the sensory responses of visual cortical neurons.

14 study of single-cell RNA sequencing of mouse cortical neurons.

15 e brain and their receptors are expressed by cortical neurons.

16 tly decreased cell viability of rat cultured cortical neurons.

17 ss pathologies in iPSC-derived glutamatergic cortical neurons.

18 both in vivo in mouse cortex and in vitro in cortical neurons.

19 ut reliability and spike-timing precision of cortical neurons.

20 ion and propagation in developing excitatory cortical neurons.

21 fferent mTORC1 activity levels in developing cortical neurons.

22 cortical volume, regardless of the number of cortical neurons.

23 to suppress or increase the excitability of cortical neurons.

24 ory information is encoded by populations of cortical neurons.

25 on mitochondrial biogenesis and function in cortical neurons.

26 ptor 2 (mGluR2), a Family C GPCR, in primary cortical neurons.

27 induced pluripotent stem cell (iPSC)-derived cortical neurons.

28 modules, which in ASD implicates superficial cortical neurons.

29 highly abundant in all, or very nearly all, cortical neurons.

30 far, acetylcholine reduces activity in some cortical neurons.

31 h a global mCH pattern reminiscent of mature cortical neurons.

32 al polypeptide (VIP) are known to disinhibit cortical neurons.

33 egrate signals from orientation tuned visual cortical neurons.

34 and coding sequences in activated prefrontal cortical neurons.

35 tegrative properties and visual responses of cortical neurons.

36 nd 1-hydroxymidazolam on network activity of cortical neurons.

37 itinerary for key synaptic molecules in rat cortical neurons.

38 tACS acts on both excitatory and inhibitory cortical neurons.

39 ed pluripotent stem cells, or in primary rat cortical neurons.

40 cts of TDP-43 dysfunction in hippocampal and cortical neurons.

41 d the receptive fields (RFs) of postsynaptic cortical neurons.

42 size and strength, altering the E/I ratio in cortical neurons.

43 ng platform to quantify endogenous NMNAT2 in cortical neurons.

44 m excitatory, glutamatergic synapses on host cortical neurons.

45 rn helps in the identification of early born cortical neurons.

46 ouse hippocampal neurons and dissociated rat cortical neurons.

47 m signaling in both organoid- and 2D-derived cortical neurons.

48 d in an in vitro model of cellular injury on cortical neurons.

49 in dopamine neurons and of medial prefrontal cortical neurons.

50 nsuring the generation of correct numbers of cortical neurons.

51 KD) result in reduced dendritic branching of cortical neurons.

52 dult nigral dopaminergic neurons and frontal cortical neurons.

53 d Abeta decreases its expression in cerebral cortical neurons.

54 um activity after optogenetic stimulation of cortical neurons.

55 lcium signalling in kidney cells and primary cortical neurons.

56 fficient to induce 1) dendritic shrinkage in cortical neurons, 2) cell-specific MDD-like gene changes

57 In cortical neurons, 5-HT enhanced expression of antioxidan

58 balance of net excitation and inhibition of cortical neurons; a significant increase in the duration

59 ships between these variables and numbers of cortical neurons across species.

60 nd synaptic genes are induced de novo during cortical neuron activation.

61 We recorded auditory cortical neuron activity from a subset of adolescent and

62 we describe electrophysiological changes in cortical neurons after recovery from hypoxia-induced SD.

63 CCR5 is uniquely expressed in cortical neurons after stroke.

64 o the hand representation in Cu to label the cortical neurons after various recovery times, and relat

65 ckdown of the unconventional myosin Myo16 in cortical neurons altered growth cone filopodia density a

66 by applying a stepwise screening strategy in cortical neurons and adult and neonatal mice.

67 number of WMNsST with labeled claustral and cortical neurons and also estimated their proportion in

68 bitory GABAergic interneurons make up 20% of cortical neurons and are critical to controlling cortica

69 this, we first developed a system combining cortical neurons and astrocytes from closely related spe

70 s been reported during normal development of cortical neurons and cerebellar white matter and may als

71 hondrial presequence processing, we employed cortical neurons and cerebral organoids generated from P

72 s mapping fundamentally shapes the tuning of cortical neurons and corresponding aspects of perception

73 ibrils (PFFs) impair GCase activity in mouse cortical neurons and differentiated dopaminergic cells,

74 n wild-type mice enhanced the firing rate of cortical neurons and gamma oscillations, as well as impr

75 tein-protein proximity network in developing cortical neurons and identified putative neuronal TRIM i

76 of mitochondrial biogenesis and function in cortical neurons and implicate the mitochondrial effects

77 system regeneration both in vitro in primary cortical neurons and in vivo in the injured adult optic

78 The number of these BDNF-expressing cortical neurons and levels of BDNF protein are highest

79 enhanced neurite outgrowth of postnatal rat cortical neurons and markedly overcame the inhibition by

80 tial role in shaping the I/O relationship of cortical neurons and must be taken into account in futur

81 r results show that the activity of auditory cortical neurons and of their striatal targets encodes t

82 f EVs, enhancing secretion of EVs by primary cortical neurons and primary cortical smooth muscle cell

83 ion and activity in cultured networks of rat cortical neurons and show that simple rules can explain

84 uencing revealed that Cx3cl1 is derived from cortical neurons, and ADAM10, a metalloprotease that cle

85 f the AMPARGluA1 in HEK293 cells and primary cortical neurons, and decreases AMPAR-mediated currents

86 y in cones, ganglion cell layer neurons, and cortical neurons, and enabled mice to perform a learned

87 integration is commonly observed in auditory cortical neurons, and potentially used by the nervous sy

88 n of the reticular system, which projects to cortical neurons, and projects to spinal motoneurons con

89 ome of which were not seen in hippocampal or cortical neurons, and resulting in neuronal hyperexcitab

90 dies in monkeys have reported that gustatory cortical neurons are broadly-tuned to multiple tastes, a

91 Under certain circumstances, cortical neurons are capable of elevating their firing f

92 The local and long-range connectivity of cortical neurons are considered instrumental to the func

93 Thus, some properties of visual cortical neurons are shaped by binocular experience, whi

94 dingly, SNORA31-mutated patient hPSC-derived cortical neurons are susceptible to HSV-1, like those fr

95 Cortical neurons are unable to use idebenone as a direct

96 ficant increase in the number of upper-layer cortical neurons, as well as abnormal dendrite and synap

97 tau overexpression assay, and a primary rat cortical neuron assay with physiological tau expression.

98 wick library of mostly approved drugs in the cortical neuron assay, leading to the identification of

99 ed to inhibit tau inclusion formation in the cortical neuron assay.

100 However, the spiking behavior of cortical neurons associated with such state changes has

101 barrier and facilitating communication among cortical neurons, astrocytes, capillaries, meninges, and

102 ir metabolic activity and viability of human cortical neurons at concentrations found in SPG5 patient

103 ema3A-Nrp1/PlxnA4 signaling pathway promotes cortical neuron basal dendrite arborization but also rep

104 and not on differences in discharge rate of cortical neurons, because there was no correlation betwe

105 dynamics and diversification in cultured rat cortical neurons (both sexes), silenced from plating.

106 increased Abeta secretion from iPSC-derived cortical neurons, but changed the cellular composition o

107 tice enhanced the sound sensitivity of adult cortical neurons, but had a weaker effect in adolescents

108 ition of endogenous halorhodopsin-expressing cortical neurons by exposure of their axons to light on

109 ations in both heterologous cells and rodent cortical neurons by patch-clamp recordings, confocal mic

110 antitatively, we mechanically stimulated rat cortical neurons by shear stress and local indentation.

111 Cortical neurons can be strongly or weakly coupled to th

112 ngly, despite this prediction, we found that cortical neurons can undergo firing rate homeostasis in

113 rafficking selectively in MB neurons but not cortical neurons caused by two PARK genes: LRRK2 (PARK8)

114 ebenone affects mitochondrial respiration in cortical neurons compared with cortical astrocytes.

115 Dynamic clamp experiments in rodent cortical neurons confirm that channel cooperativity can

116 little is known about how different types of cortical neurons convert correlated inputs into correlat

117 Cortical neurons cultured from the Ts2 mouse model of DS

118 evoked calcium transients in primary murine cortical neuron cultures transduced with an adeno-associ

119 Here, using cell lines and primary cortical neuron cultures, recombinant protein expression

120 d proteins in HeLa cells and wild-type mouse cortical neuron cultures.

121 neuroblastoma SH-SY5Y cell line and primary cortical neuron cultures.

122 a single chemical concentration on mixed sex cortical neuron cultures.

123 scriptomic changes associated with selective cortical neuron damage and glial activation contributing

124 asmic domain is required for Sema3A-mediated cortical neuron dendritic elaboration but is dispensable

125 gnaling molecules to promote Sema3A-mediated cortical neuron dendritic elaboration, but not inhibitor

126 at RNA foci and dipeptide repeat proteins in cortical neurons derived from induced pluripotent stem c

127 hiPSCs, neural precursor cells, and cortical neurons derived from six healthy controls and s

128 d immunocytochemical experiments in cultured cortical neurons derived from transgenic Ubap1flox mice

129 Nucleofection of primary cortical neurons, derived from E16-18 mouse embryos (bot

130 Cortical neurons developed selectivity for the learned s

131 In the most immature ferrets, cortical neurons developed selectivity to these patterns

132 They then uncover unique roles of DDX3X in cortical neuron development and ribonucleoprotein granul

133 role of miR-26a in early stage mouse primary cortical neuron development.

134 oup) in schizophrenia, as well as in frontal cortical neurons differentiated from a subject with schi

135 Using FTD-PGRN patient-derived cortical neurons differentiated from induced pluripotent

136 Here we demonstrate that cortical neurons directly innervate the brainstem to dri

137 P-43 RNP granules in axons of rodent primary cortical neurons display liquid-like properties, includi

138 with brief MD.SIGNIFICANCE STATEMENT Visual cortical neurons display varying degree of responsivenes

139 (2019) examines the activity of thousands of cortical neurons during a navigation task and reveals th

140 transcriptome profiling of immature primary cortical neurons during early axon formation, we discove

141 As these hNPCs generate the cortical neurons during early brain development, the ZIK

142 our knowledge of the dendritic structure of cortical neurons during early postnatal development and

143 Here we show that inhibition of cortical neurons during postnatal development causes def

144 were several differences in the activity of cortical neurons during reaches by the affected limb com

145 We found that auditory cortical neurons encode not only sound identity, but als

146 Cortical neurons exhibit extreme diversity in gene expre

147 , mice with a conditional Iqsec1 deletion in cortical neurons exhibited an increased density of dendr

148 We described populations of cortical neurons expressing sequential patterns of activ

149 Cortical neurons fall along a continuum in their sensiti

150 Accelerated differentiation into cortical neuron fates should facilitate hPSC-based strat

151 r, the spike firing properties of individual cortical neurons following training remain unknown.

152 ation of outwardly radiating F-actin rods in cortical neurons from APPswe/PS1DeltaE9 mice.

153 Excitatory cortical neurons from both patients had prolonged action

154 ingly, however, we found that cultured mouse cortical neurons from both sexes grown on multi-electrod

155 iR-27a-3p or miR-223-3p protects dissociated cortical neurons from condition media mediated degenerat

156 ating expression of isoform-A or -D protects cortical neurons from death caused by the expression of

157 Using dissociated cortical neurons from embryonic Rattus norvegicus, we fo

158 rial pyruvate carrier (MPC) protects primary cortical neurons from excitotoxic death.

159 Cortical neurons from G2019S-LRRK2 mice showed an increa

160 ocampal and adjacent somatosensory pyramidal cortical neurons from male and female postnatal day (P)2

161 a protocol to derive separate two-deep layer cortical neurons from mouse ESCs (mESCs).

162 We generated iPSC-derived cortical neurons from myoclonus-dystonia patients with m

163 ologic and functional properties of Layer VI cortical neurons from Ntsr1-EGFP; Foxp2(+/R552H) male an

164 In iPSC-derived cortical neurons from patients with AP4B1-associated SPG

165 how that betaIII spectrin in hippocampal and cortical neurons from rodent embryos of both sexes is di

166 a mammalian expression system, and protected cortical neurons from slow excitotoxic injury in vitro,

167 ged by HCAR1 activation, using mouse primary cortical neurons from wild-type (WT) and HCAR1 knock-out

168 ll analysis were performed in primary murine cortical neurons from wild-type (WT) and/or ryanodine re

169 ntaneous calcium spiking activity of primary cortical neurons from WT but not from HCAR1 KO mice.

170 he idiosyncratic responses of populations of cortical neurons, giving rise to a high-dimensional repr

171 In cultured mouse cortical neurons, glucose deprivation, pharmacological a

172 Ube3b (-/-) cortical neurons had abnormal dendritic morphology and s

173 Anti-VP1 staining demonstrated infection in cortical neurons, hippocampal neurons, and glial and end

174 roteins RIM1alphabeta (RIM1) from excitatory cortical neurons impairs corticostriatal synaptic transm

175 Here, we cultured cortical neurons in a chamber with sequentially connecte

176 a read-out of action potentials from labeled cortical neurons in a rat brain slice, without the need

177 e dynamics and motility of the axonal GCs of cortical neurons in an EB1-dependent manner and is requi

178 visually guided intracellular recordings of cortical neurons in awake mice, we measured the voltage

179 s of a group of these genes in primary mouse cortical neurons in basal conditions and upon overexpres

180 nd to be expressed transiently in developing cortical neurons in culture and in developing mouse cort

181 Further, in both the OFC and primary cortical neurons in culture, ketamine increased expressi

182 we studied neurite outgrowth in rat primary cortical neurons in culture.

183 neurotrophic factor (BDNF)-induced pTRKB in cortical neurons in culture.

184 2019) find reduced feedforward inhibition in cortical neurons in four genetic mouse models of autism

185 and to extract calcium receptive fields from cortical neurons in mammals.

186 ocyte conditioned media (ACM) on retinal and cortical neurons in metabolic stress models.

187 vivo two-photon Ca(2+) imaging of layer 2/3 cortical neurons in mice expressing human Abeta and tau,

188 required for the survival of hippocampal and cortical neurons in mice.

189 r lamin B2 cause both defective migration of cortical neurons in the developing brain and reduced neu

190 nty is encoded in the population activity of cortical neurons in the form of likelihood functions.

191 Consequently, cortical neurons in the mice have higher synapse density

192 MADM cortical neurons in vitro reveal that eB3 controls synap

193 neurite complexity of surviving DAergic and cortical neurons, in parallel with benefits in motor per

194 AD patients and 5xFAD mice, and in cerebral cortical neurons incubated with soluble Abeta.

195 essed FUS toxicity in Drosophila and primary cortical neurons, indicating a link between FUS and SMN.

196 ely timed spiking activity in the network of cortical neurons; irregular spiking can interfere with i

197 For example, hyperexcitability of cortical neurons is associated with both epilepsy and au

198 -dependent tangential migration of GABAergic cortical neurons is driven by depolarizing responses to

199 , molecular, and physiological properties of cortical neurons is important for understanding their co

200 hat TCF4-controlled transcription in primary cortical neurons is induced by neuronal activity and pro

201 Conversely, dendritic morphology of female cortical neurons is more complex than males.

202 lays are consistent with the distribution of cortical neuron latencies and that temporal motion integ

203 afted or endogenous halorhodopsin-expressing cortical neurons, located in the same area, and after in

204 We found that cortical neurons lose their positional identity and axon

205 A reduction of p53 also partially rescued cortical neuron loss.

206 o probe the importance of the interaction in cortical neuron migration.

207 abeling demonstrates that, in FMRP-deficient cortical neurons, mRNA down-regulation is caused by elev

208 udies find that reducing polyamines enhances cortical neuron nAChR expression and augments nicotine-m

209 ssed GluN2A(N615K) in cultured primary mouse cortical neurons, observing a decrease in Mg(2+) blockad

210 eed, whether rewiring of connections between cortical neurons occurs during behavioral training, as i

211 , dynamics, and recurrence were validated in cortical neurons of acute brain slices.

212 Dopaminergic nigral and cortical neurons of both LRRK2 G2019S and idiopathic PD

213 HEK cells as well as in native receptors in cortical neurons of C57BL/6J mice of either sex, indicat

214 and extensive dendritic varicosities in the cortical neurons of CM-infected brain.

215 o altered chloride homeostasis in developing cortical neurons of FXS mice, rectifies the chloride imb

216 r mtDNA release in brain and primary cerebro-cortical neurons of melatonin-deficient aralkylamine N-a

217 c branching and spine density are reduced in cortical neurons of Ube3A 2X ASD mice.

218 In part, this may be due to variable cortical neuron orientation relative to the electric fie

219 early life drives the matching of individual cortical neurons' orientation preferences through the tw

220 HT22 cells and embryonic cortical neurons overexpressing 40 kDa (CPE/NF-alpha1)-D

221 mutant does not have an inverted cortex, but cortical neurons overmigrate and invade the marginal zon

222 , anatomical and molecular phenotypes of the cortical neuron populations that express FOXP2 were char

223 tonic, anesthetic dose-dependent behavior of cortical neuron populations.

224 , and overexpression of Zfp189 in prefrontal cortical neurons preferentially activates this network a

225 ation of action potentials into dendrites of cortical neurons, preventing spike-timing-dependent syna

226 Finally, in a cortical neuron primary culture, both Nanobodies were ab

227 Cortical neurons process information on multiple timesca

228 eletion of Nrp2 selectively in adult layer V cortical neurons produces a similar increase in the numb

229 Importantly, the distributions of cortical neurons projecting to each of the two nuclei we

230 Frontal top-down cortical neurons projecting to sensory cortical regions

231 Distinct neural activity signatures of cortical neurons projecting to the brainstem before bing

232 be directed to generate specific deep-layer cortical neurons rather than heterogeneous cortical neur

233 Some cortical neurons receive highly selective thalamocortica

234 neuron perturbations to directly measure how cortical neurons reshape sensory representations.

235 First, cortical neurons respond reliably to a restricted set of

236 ave a predominant role in the selectivity of cortical neuron responses to visual stimuli.

237 e through GABA(A) receptors during the CP in cortical neurons restores their synaptic development, ha

238 nstrate that knockdown of NEUROD2 in primary cortical neurons resulted in a strong increase in Reln g

239 induced pluripotent stem cell (iPSC)-derived cortical neurons secrete Abeta peptides in ratios compar

240 and primates originates with primary visual cortical neurons selective for motion direction.

241 n intact or sliced assembloids, we show that cortical neurons send axonal projections into striatal o

242 induced pluripotent stem (iPS) cell-derived cortical neurons send widespread axonal projections to b

243 ncreased progranulin levels in mouse primary cortical neurons; several of these also raised progranul

244 Gain-of-function experiments using primary cortical neurons show that increasing the levels of eith

245 citability in both excitatory and inhibitory cortical neurons show that selective dysfunction of neur

246 first mechanistic description of how visual cortical neurons signal depth from MP.SIGNIFICANCE STATE

247 results provide the first evidence that some cortical neurons specialize in processing shape whereas

248 nd EPSCs, produces sparse and reliably timed cortical neuron spike trains to be transmitted downstrea

249 T/beta-catenin signaling in regulating human cortical neuron subtype fate specification, which is dis

250 ration and differentiation to produce mature cortical neuron subtypes is essential for the study of h

251 ed in both infected and uninfected bystander cortical neurons, suggesting a role for paracrine factor

252 protein expression was also higher in female cortical neurons, suggesting that DRG findings may be ge

253 ampal neurons but also higher-firing frontal cortical neurons, suggestive of greater plasticity in th

254 an cell lines and primary post-mitotic mouse cortical neurons support prime editing with varying effi

255 r human pluripotent stem cell (hPSC)-derived cortical neurons susceptible to HSV-1.

256 r cortical neurons rather than heterogeneous cortical neurons that are generated using the monolayer

257 Motion sense depends on cortical neurons that are selective for motion direction

258 Cortical neurons that encode different types of informat

259 Cortical neurons that influence parasympathetic output t

260 In contrast, cortical neurons that influence sympathetic output to th

261 The function of cortical neurons that recover from hypoxia-induced sprea

262 Here we show a subpopulation of embryonic cortical neurons that transiently express nestin in thei

263 vity might increase together with numbers of cortical neurons through their impact on three main fact

264 spike-field coherence of a rat primary motor cortical neuron to the LFP theta rhythm.

265 elated population of abnormally synchronized cortical neurons to activate the adjacent sub-population

266 ed short term dynamics of L2/3 murine visual cortical neurons to evaluate the relative importance of

267 portant contribution of feedback signals for cortical neurons to recalibrate their sensitivity.

268 ein (GFP)-labeled envelopes and infected the cortical neurons to study axonal transport of H129 viral

269 s anatomical progression from monocular, pre-cortical neurons to their binocular, cortical counterpar

270 Remarkably, auditory cortical neurons track the temporal dynamics of purely v

271 We previously reported that embryonic motor cortical neurons transplanted immediately after lesions

272 of emerging neuronal spike synchrony between cortical neurons tuned to different frequencies.

273 the rapid kinetics of miR-132 activation in cortical neurons under physiological conditions.

274 ing the axonal projections of layer-specific cortical neurons using Cre-dependent AAV vectors and for

275 d this phenomenon in primary cultures of rat cortical neurons using overexpression of dominant-negati

276 he enrichment of glutamate in SVs of primary cortical neurons using targeted polar metabolomics.

277 or of the synaptic vesicle cycle in cerebral cortical neurons via its ability to induce presynaptic r

278 ochondrial biogenesis and function in rodent cortical neurons, via a 5-HT(2A) receptor-mediated recru

279 Function of iPSC-derived cortical neurons was assessed using molecular approaches

280 owever, the intrinsic excitability of Foxp2+ cortical neurons was lower in Foxp2(+/R552H) neurons.

281 tional connectivity between choice-selective cortical neurons was recently reported.

282 the feedforward sensory features that drive cortical neurons, we have a limited grasp on the structu

283 knowledge of the sensory features that drive cortical neurons, we have a limited grasp on the structu

284 ssays and proteomics of lysates from primary cortical neurons, we identified that an EAG channel, hER

285 The data obtained on cultured rat cortical neurons were compared with the data obtained on

286 deficiency affects Na(+)/K(+) pump capacity, cortical neurons were differentiated from iPSCs generate

287 The embryonic precursors of these cortical neurons were in utero electroporated with CBSH3

288 Finally, the labeled cortical neurons were predominately in layer 6, and laye

289 A subset of autism-iPSC cortical neurons were RNA-sequenced to reveal autism-spe

290 -gamma oscillations and firing properties of cortical neurons, which affected goal-directed behaviors

291 on level is hindered by the heterogeneity of cortical neurons, which differ in the composition of the

292 just as long as expected for their number of cortical neurons, which eliminates the basis for earlier

293 i are encoded collectively by populations of cortical neurons, which transmit information by using a

294 aracterized by ongoing irregular activity of cortical neurons while during slow wave sleep (SWS) thes

295 Treatment of cultured cortical neurons with E2 reduced the accumulation of GAB

296 Preincubation of cortical neurons with PolyP significantly reduced the in

297 n highlights the suitability of iPSC-derived cortical neurons with SGCE mutations for myoclonus-dysto

298 ut simultaneous recordings from thousands of cortical neurons with shared sensory inputs, it is unkno

299 Recurrence among cortical neurons with similar selectivity therefore driv

300 orically analyzed the encoding properties of cortical neurons without considering cell types.