ライフサイエンスコーパス: cortisone

1 tive glucocorticoid, cortisol, with inactive cortisone.

2 at interconvert active cortisol and inactive cortisone.

3 nished ability to convert [11-3H]cortisol to cortisone.

4 verts hormonally active cortisol to inactive cortisone.

5 at interconvert active cortisol and inactive cortisone.

6 pe 1 (11beta-HSD1) regenerates cortisol from cortisone.

7 and the binding selectivity of cortisol over cortisone.

8 interconversion of active cortisol and inert cortisone.

9 by converting active cortisol into inactive cortisone.

10 ts as a dehydrogenase converting cortisol to cortisone.

11 eta2 showed only inactivation of cortisol to cortisone.

12 r synthesis of active cortisol from inactive cortisone.

13 f biologically inactive 11 keto derivatives (cortisone, 11-dehydrocorticosterone) to active glucocort

14 terone) and their inert 11-keto derivatives (cortisone, 11-dehydrocorticosterone).

15 d3-cortisol 5.9 +/- 1.8 pmol/100 mL/min, and cortisone 15.2 +/- 5.8 pmol/100 mL/min) and splanchnic (

16 /min, d3-cortisol 12.9 +/- 2.1 nmol/min, and cortisone 19.5 +/- 2.8 nmol/min) circulations.

17 After oral cortisone (25 mg), cortisol concentrations within adipos

18 teady state and after oral administration of cortisone (5 mg) to estimate whole-body and liver 11beta

19 d compared outcomes in mice with and without cortisone acetate (CA) immunosuppression.

20 ption of luminal virus, a process blocked by cortisone acetate administration, which prevented ileal

21 simultaneous adipose microdialysis and oral cortisone acetate administration.

22 ropenic mice that were immunosuppressed with cortisone acetate and infected with the Deltaace2 mutant

23 ceptible to oral infection by injection with cortisone acetate and then inoculated by placing a swab

24 Cortisone acetate gave results similar to dexamethasone,

25 The effect of GM-CSF on cortisone acetate suppression lasted at least 7 days.

26 e gave results similar to dexamethasone, but cortisone acetate suppression of BAM responses lasted 7

27 Either cyclophosphamide or cortisone acetate treatment could cause reactivation, bu

28 everely immunosuppressed by cyclophosphamide-cortisone acetate treatment.

29 ivo administration of saline, dexamethasone, cortisone acetate, granulocyte-macrophage colony-stimula

30 emotherapeutic antiangiogenic agents tested: cortisone acetate, vincristine, bleomycin, Adriamycin, 5

31 of the A. fumigatus protein Asp f3 protected cortisone acetate-immunosuppressed mice from experimenta

32 ailed monkeys treated orally for 1 year with cortisone acetate.

33 Conversion of cortisone (administered as 25 mg orally) to cortisol in

34 corticosterone) and their inactive versions (cortisone and 11-dehydrocorticosterone) were measured by

35 d2-Cortisone and 9,11,12,12-[(2)H](4)-cortisol (d4-cortisol

36 rotein that catalyzes the interconversion of cortisone and cortisol.

37 rast, ROS 17/2.8beta1 were sensitive to both cortisone and cortisol.

38 he combination of plasminactivator, heparin, cortisone and cyclosporine has proven to be effective in

39 al combination of plasminactivator, heparin, cortisone and cyclosporine.

40 nistically distinct anti-inflammatory drugs, cortisone and ibuprofen, significantly inhibited angioge

41 on of hormonally active cortisol to inactive cortisone and is vital for dictating specificity for the

42 Complexes with cortisone and progesterone reveal productive substrate b

43 oacyl-tRNA biosynthesis; and in CSF involved cortisone and prostaglandin 2 biosynthesis and metabolis

44 y steroidal drugs (such as dexamethasone and cortisone) and nonsteroidal anti-inflammatory drugs (suc

45 rtisone to cortisol greater than cortisol to cortisone) and was higher in omental than subcutaneous f

46 tomical site differences in glucocorticoids, cortisone, and 11-deoxycorticosterone.

47 -HSD1), which generates active cortisol from cortisone, and 5alpha-reductase (5alphaR), which inactiv

48 d catecholamines and glucocorticoids, except cortisone, and delayed recovery in heart rate but not ac

49 lysoPC(15:0), oxymorphone-3b-D-glucuronide, cortisone, and oleoyl-glycerol.

50 analysis using stable isotope-labeled (SIL) cortisone as a substrate was developed.

51 eral analytes, including indoxyl sulfate and cortisone, as well as metabolite enrichment in the kynur

52 HEPES bound in the active site), NADP(+) and cortisone at 1.90-A resolution, NADP(+) and progesterone

53 culating glucocorticoid, and its metabolite, cortisone, both equally stimulate the growth of these Ca

54 duced cortisol production by 85% following a cortisone challenge.

55 gnificantly higher sums of hair cortisol and cortisone concentrations (beta, 0.28 [95% CI, 0.12 to 0.

56 kers were quantified by summing cortisol and cortisone concentrations measured with liquid chromatogr

57 tified daily and ultradian variation in free cortisone, corticosterone, 18-hydroxycortisol, aldostero

58 ocytes after inhibition of the intracellular cortisone-cortisol shuttle 11beta-hydroxysteroid dehydro

59 to enantioselective versions, including (1) cortisone/cortisol (Merck/Sarett), (2) dendrobine (Kende

60 lites, a process commonly referred to as the cortisone/cortisol shuttle.

61 Fetal tissue cortisone: cortisol tended to be reduced (P = 0.06) and

62 1,2-[(2)H](2)-Cortisone (d2-cortisone) was validated as a tracer for 1

63 deuterium during conversion to [9,12,12-2H3] cortisone (D3-cortisone), which in turn generates [9,12,

64 -HSD) interconvert cortisol (F) and inactive cortisone (E), and are thus able to modulate GC action a

65 ies supplemented with physiologic amounts of cortisone, however, display normal SC ultrastructure on

66 longer tested positive by xenodiagnosis, and cortisone immunosuppression did not alter this result.

67 yses reductase regeneration of cortisol from cortisone in adipose and liver.

68 humans) and inert 11-dehydrocorticosterone (cortisone in humans).

69 al concentrations of free cortisol and total cortisone in men greatly exceed the binding affinity of

70 Active recycling between cortisol and cortisone in metabolic tissues in vivo may facilitate dy

71 1) enzyme regenerates cortisol from inactive cortisone in tissues such as liver and adipose.

72 of clobetasol propionate (CLO), cortisol and cortisone in zebrafish embryos as single compounds and b

73 ted by production of SIL-cortisol during SIL-cortisone infusion.

74 dehydrogenase (HSD) type 1 converts inactive cortisone into active cortisol in cells, thereby raising

75 rogenase type-1 (11beta-HSD1) converts inert cortisone into active cortisol, amplifying intracellular

76 th cell types were able not only to activate cortisone into the active form cortisol, but also to syn

77 nase type 1 (11beta-HSD-1) converts inactive cortisone into the active glucocorticoid cortisol and th

78 In contrast, the viscera releases cortisone into the portal vein, thereby providing substr

79 The inactive GC cortisone is converted by 11beta-HSD1 to active GC corti

80 Inactive cortisone is converted to active cortisol by the reducta

81 In contrast, cortisone led to down-regulation of vitellogenin.

82 biological stress levels (i.e., cortisol and cortisone levels), but not perceived stress, among both

83 t revealed a moderately elevated cortisol to cortisone metabolite ratio.

84 videnced by an abnormal ratio of cortisol to cortisone metabolites and by an exceedingly diminished a

85 ry tuberculosis (PTB), the ratio of cortisol/cortisone metabolites in 24-h urine showed a shift towar

86 d with A. fumigatus, suggesting an effect of cortisone on bronchial spore clearance.

87 17/2.8beta1 decreased further with exogenous cortisone or cortisol whereas ROS 17/2.8beta2 were resis

88 P-9 into the HT-1080 onplants engrafted into cortisone- or ibuprofen-treated embryos reversed the ant

89 ry low in visceral fat, the viscera released cortisone (P < 0.001) and D3 cortisone (P < 0.01) into t

90 rticosterone (p < 0.001) as well as cortisol:cortisone (p < 0.001).

91 sol (p < 0.001), corticosterone (p < 0.001), cortisone (p < 0.006) 11-dehydrocorticosterone (p < 0.00

92 iscera released cortisone (P < 0.001) and D3 cortisone (P < 0.01) into the portal vein.

93 For size-selected cortisone particles between 30 and 90 nm diameter and SO

94 nto the ion formation process: size-selected cortisone particles, size-selected secondary organic aer

95 fine the means through which the FF cortisol:cortisone ratio determines oocyte competency.

96 Cortisol/cortisone ratio was increased in bronchoalveolar lavage

97 ed AR functioned as a high-affinity cortisol/cortisone receptor (ARccr).

98 In cortisone reductase deficiency (CRD), activation of cort

99 Apparent cortisone reductase deficiency is characterized by andro

100 ridging therapeutic option for severe acute, cortisone refractory ulcerative colitis in Covid-19 pati

101 A cortisone-refractory course was noticed.

102 se was more readily detected than reductase (cortisone release 38.7 +/- 5.8 pmol/100 g/min).

103 performance test mix-composed of aspartame, cortisone, reserpine, and dioctyl phthalate has been dev

104 ly, donor lymphocyte infusion induced severe cortisone-resistant gastrointestinal graft-versus-host d

105 tine during their postnatal development, and cortisone selectively regulates ileal but not kidney TC

106 CLO and cortisol, but not cortisone showed a concentration-dependent decrease in m

107 iltrating T cells, and modulate the cortisol-cortisone shuttle so that the inflammatory site becomes

108 ursors 11-dehydrocorticosterone (11-DHC) and cortisone suppress voltage-dependent Ca(2+) channel func

109 Amniotic fluid cortisone tended to decrease (P = 0.07), while cortisol

110 The initiation of a high-dose oral cortisone therapy did not improve the clinical symptoms.

111 , can generate active cortisol from inactive cortisone through the expression of 11 beta-HSD1.

112 ogenase type 1 (11beta-HSD1) enzyme converts cortisone to cortisol and participates in the regulation

113 ne reductase deficiency (CRD), activation of cortisone to cortisol does not occur, resulting in adren

114 nt activity was oxo-reductase (conversion of cortisone to cortisol greater than cortisol to cortisone

115 ts active form corticosterone in rodents (or cortisone to cortisol in humans).

116 talyzed conversion of stable-isotope-labeled cortisone to cortisol in liver microsomes from dog, monk

117 The reduction of cortisone to cortisol is catalyzed by 11beta-hydroxyster

118 The ratio of urinary free cortisone to cortisol measured by using a radioimmunoass

119 oximating extraadrenal tissues by converting cortisone to cortisol via the 11beta-hydroxysteroid dehy

120 vivo, 11beta-HSD1 catalyzes the reduction of cortisone to cortisol whereas purified enzyme acts as a

121 ROS 17/2.8beta1 showed net conversion of cortisone to cortisol whereas ROS 17/2.8beta2 showed onl

122 demonstrate that 11beta-HSD1, which converts cortisone to cortisol, is expressed only upon differenti

123 was higher in omental than subcutaneous fat (cortisone to cortisol, median 57.6 pmol mg-1 h-1 [95% CI

124 1 (11beta-HSD1) is the enzyme that converts cortisone to cortisol.

125 1 (11beta-HSD1) is the enzyme that converts cortisone to cortisol.

126 protein and an elevated capacity to convert cortisone to cortisol.

127 s, evidenced by the restricted conversion of cortisone to cortisol.

128 in the ability of the adipocytes to convert cortisone to cortisol.

129 a-HSD1) catalyzes the conversion of inactive cortisone to its active form, cortisol.

130 The interconversion from M+4 cortisone to M+4 cortisol was detected in dog, human, an

131 The conversion of SIL-cortisone to SIL-cortisol in rhesus monkey adipose tissu

132 pe 1 (11beta-HSD1), which primarily converts cortisone to the active glucocorticoid (GC) cortisol.

133 tained using a microdialysis infusion of M+4 cortisone to the microsomes coincubated with a proprieta

134 deficient A. nidulans was highly virulent in cortisone-treated BALB/c mice.

135 -encoding genes was observed in the lungs of cortisone-treated mice during early invasive aspergillos

136 pidly to baseline levels in cyclophosphamide/cortisone-treated mice.

137 Splenectomy or high-dose cortisone treatment had no effect on the shorter surviva

138 Cortisone treatment reversed these changes noted in the

139 ly in adrenalectomized rats before and after cortisone treatment.

140 re, Asian or Hispanic heritage, smoking, and cortisone use were associated with significantly increas

141 The conversion of cortisol to cortisone was 58% compared with 0-6% in typical patients

142 glucocorticoid marker in ovary extracts, and cortisone was abundant in extracts of both testes and ov

143 in the intrafollicular ratio of cortisol to cortisone was observed in the blastocyst group.

144 ol appearance in the hepatic vein after oral cortisone was unchanged.

145 1,2-[(2)H](2)-Cortisone (d2-cortisone) was validated as a tracer for 11beta-dehydrog

146 yme, 11beta-HSD2, which converts cortisol to cortisone, was not detectable in either monocytes or cul

147 ctive rodent dehydrocorticosterone and human cortisone were able to substitute for the synthetic gluc

148 1.0 and 0.5 microL/min, E(d) values for SIL-cortisone were between 58.7+/-5.6% (n=4) and 72.7+/-1.3%

149 ions containing 100, 500, and 1000 ng/mL SIL-cortisone were locally delivered through an implanted 30

150 ng conversion to [9,12,12-2H3] cortisone (D3-cortisone), which in turn generates [9,12,12(2)H3] corti