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1 ) proteins were individually responsible for counteracting 53BP1-RIF1-Shieldin activity and promoting
2 ment in the opposite direction; thus, it can counteract a process that specifically off-centers the s
4 cooperation whereby Mir142 loss-of-function counteracts aberrant silencing of Hoxa cluster genes by
5 y, these results demonstrate that PR-DUB, by counteracting accumulation of H2AK119ub1, maintains chro
10 gest this system is co-opted in the brain to counteract and regulate aberrant nerve terminal growth.
12 actamase inhibitors are increasingly used to counteract antibiotic resistance mediated by beta-lactam
18 thogen Pseudomonas syringae that is known to counteract Arabidopsis defense through mimicking defense
20 erating the reduction of Ni(II) to Ni(0) and counteracting autoinhibition of reduction at Zn(0) by Zn
21 circadian system as a potential strategy to counteract beta-cell failure under diabetogenic conditio
23 very of rAAV9-amiR-shn3 in osteoporotic mice counteracted bone loss and enhanced bone mechanical prop
24 hese findings show that a novel lncRNA SCIRT counteracts breast tumorigenesis by opposing transcripti
25 uman immunodeficiency virus type 1, which is counteracted by a virus-encoded degradation mechanism(1-
26 Na(+) and Ca(2+) channels that is initially counteracted by aberrant increases in cell size and cond
27 ems, the expression/activity of the toxin is counteracted by an antitoxin, which, in type I systems,
28 n induced by N deposition on GPP(max) may be counteracted by an earlier and faster dry-down in partic
29 These inflammatory responses are potentially counteracted by anti-inflammatory cytokines and type 2 r
32 ediated changes in phagocyte activation were counteracted by changes in IFN-gamma-mediated recruitmen
33 cretion by monocytes and other cell types is counteracted by constant uptake and internalization by C
35 resistance development and how this could be counteracted by detailed studies of microbiome compositi
38 IFN-gamma-mediated phagocyte activation are counteracted by effects on IFN-gamma-dependent recruitme
40 sing BH3-mimetic whose cytotoxic activity is counteracted by high Mcl-1/Bcl-xL expression and increas
41 for agricultural land, yet this recovery was counteracted by increased impacts of other pressures (no
42 st all of the increases in insolubility were counteracted by increases in solubility of other protein
43 ncreased the crumb hardness, but it could be counteracted by increasing dough hydration and adapting
44 characterized by hyperglycemia, which can be counteracted by inhibition of alpha-glucosidase and alph
47 id ROS production in many tumor types and is counteracted by metabolites that are derived from the am
48 entially pro-atherogenic effects are however counteracted by neutropenia in circulation and plaque.
49 y, we find that this protection could not be counteracted by promoted decomposition due to the primin
53 When turbulent stresses are less able to be counteracted by surface tension, a 3-dimensional (3D) ki
54 -mediated decrease in insulin sensitivity is counteracted by the expression of a constitutively activ
55 of diverse retroviruses, and its activity is counteracted by the glycosylated Gag (glycoGag) protein
56 ng signaling helix at the dimer interface is counteracted by the ligand-induced structural changes fr
58 f biodiversity on one trophic level were not counteracted by the negative effects on adjacent levels.
60 cts inclusion growth and that this effect is counteracted by the secretion of the bacterial effector
63 es angiogenesis through a novel mechanism by counteracting c-Myc and transcriptionally repressing vas
64 ing or removal of calpain-1 in cells or mice counteracted calpain system overactivation and led to re
67 havioral interventions have been explored to counteract cocaine addiction, but to date no market-appr
69 ics, and, as a proof of concept, effectively counteract common inflammatory and myeloid disease state
71 est a compensatory mechanism in the brain to counteract corticotropin-releasing factor and/or stress.
74 ated MSCs (eMSCs) into the lateral ventricle counteracted depressive-like behavior and enhanced the e
75 antioxidant compounds was not successful in counteracting disease initiation and progression in clin
76 ory transpulmonary pressure strategy aims to counteract dorsal lung collapse, whereas electrical impe
77 thus suggesting that HRH1 and SSTR1 probably counteract each other in regulating KSHV-infected endoth
78 toration strategies are emerging globally to counteract ecosystem degradation and biodiversity loss.
80 identified pathogenic variants operate with counteracting effects on MAPK1 function by differentiall
84 ted in tumorspheres but colocalized with and counteracted EZH2 and SOX2 during cell-cycle and self-re
85 f genetic diversity during domestication and counteracting factors, a discussion of the relationship
91 , which were suggested to be responsible for counteracting glutamate toxicity in neuronal human-deriv
92 KB directly phosphorylates MYC at serine 67, counteracting GSK3beta-directed threonine 58 phosphoryla
97 and BL1249 induced TREK-1 currents in AECs, counteracted HO-induced cell depolarization, and lowered
98 arsenal that hijacks cellular components and counteracts host immune responses, is a prototypical mod
104 pleting regulatory T cells (T(reg) cells) to counteract immunosuppressive features of the tumor micro
105 thods, like cloud seeding, are being used to counteract increasing water scarcity in arid regions.
107 kermansia muciniphila, has been suggested to counteract inflammation elicited by P. gingivalis In thi
108 ndications for repurposing this safe drug to counteract inflammation, which contributes to many human
109 gulated under obesity conditions and thereby counteracts inflammation of peripheral insulin-sensitive
110 e findings explain how oncogenic mutants can counteract inhibitory mechanisms to constitutively activ
114 ed spine loss, therapies can be developed to counteract irradiation-induced cognitive decline and imp
116 tion selectively blocks NF-kappaB, likely to counteract its antiviral effects and promote efficient v
117 identification of novel approaches aiming to counteract its cytotoxic effects will be desirable to de
121 Pp1-87B phosphatase dephosphorylates moesin, counteracting its activation by the Ste20-like kinase Sl
123 protein phosphatase 2A (PP2A), that normally counteract kinases, contributes to aberrant signaling.
124 TP production could improve immune function, counteracting LA suppressive effects in the immunosuppre
128 a poorly studied protein phosphatase, PPM1H, counteracts LRRK2 signaling by specifically dephosphoryl
129 C-terminal moieties of its cellular partners counteracts MAST2-mediated suppression of neurite outgro
133 gene and suggests therapeutic strategies to counteract metastatic dissemination of pancreatic and pr
134 reduces oxidized actin monomers and thereby counteracts MICAL1, an enzyme known to depolymerize acti
135 is article, they describe lessons learned to counteract misleading information and nudge the research
136 CE may represent a new therapeutic target to counteract Mk proliferation and its clinical consequence
137 via G(q/11) is necessary and sufficient for counteracting MOR-mediated inhibition of neuronal firing
139 ce may activate compensatory mechanisms that counteract muscle degradation caused by loss of dystroph
140 we show that the FSTA CK-2066260 effectively counteracts muscle fatigue in rodent skeletal muscle in
141 ion and survival of primary human B cells by counteracting MYC-induced apoptosis and by inhibiting RB
144 al product that inhibits PIEZO2 function and counteracts neuronal mechanical sensitization and reveal
145 rinsic cell proliferation to synergistically counteract niche cell pool depletion during the animal's
148 2 up-regulation is a protective mechanism to counteract obesity-induced glucose intolerance by decrea
150 articularly the use of explicit re-aiming to counteract observed target errors, patients with cerebel
152 ns about how responses to sensory pollutants counteract or exacerbate responses to other aspects of g
154 o accumulate cells and proline metabolism to counteract oxidative stress, during growth at 4 degrees
156 ive roles of elevated ketones and lactate in counteracting oxidative stress and as a fuel source for
158 unities and challenges in the field, such as counteracting PARP inhibitor resistance during cancer th
159 s cardio-protective in diabetes mellitus and counteracts pathological Ca(2+)/calmodulin-dependent pro
160 ng Xenopus laevis egg extracts that the Cdk1-counteracting phosphatase PP2A-B55 functions as a bistab
162 light conditions and metabolic demands, but counteracting phosphatase(s) remain unknown in C. reinha
163 DK1 activity relieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55, allowing wi
164 ine with these findings, SARS-CoV-2 fails to counteract phosphorylation of STAT1 and expression of IS
167 nc13 gene disruption in beta-cells partially counteracts polyinosinic-polycytidylic acid (PIC)-induce
169 C/C(CDC20) is regulated by CDK1-cyclin B and counteracting PP1 and PP2A family phosphatases through m
170 We further determined that inflammation can counteract pregnancy-dependent suppression of maternal h
171 ways respond to ER stress, but how they help counteract protein misfolding is incompletely understood
172 anscription factor Nrf1 (also called NFE2L1) counteracts proteotoxic stress by inducing transcription
175 utoimmune disease observed in females, and a counteracting reduction in diseases such as cancer that
176 y role in maintaining active replication and counteracting replication stress by regulating the repli
178 nd inappropriate activation of ATM, but also counteracts replication conflicts at DNA secondary struc
179 gulators that form multiprotein complexes to counteract repressive developmental gene expression prog
181 ype, pointing to a new therapeutic target to counteract retinal degeneration associated with lysosoma
183 Because sexual RNA replication mechanisms counteract ribavirin-induced error catastrophe, we selec
185 binding with TaSnRK1alpha, demonstrating the counteracting roles of orphan proteins of both host and
186 re, partial inhibition of the mTORC1 pathway counteracted sarcopenia, as determined by observing an i
187 its targets and timing and of the benefit of counteracting self-generated sensory input.SIGNIFICANCE
188 gest that the differential ability of Nef to counteract SERINC5 by naturally occurring immune-associa
190 und effect on melanoma growth and is able to counteract Sox10-dependent melanoma maintenance both in
191 y SARS-CoV-2 alone but detect the failure to counteract STAT1 phosphorylation upon IFN-I pretreatment
192 developing systemic telomere therapeutics to counteract stem cell exhaustion in DC, PF, and possibly
194 diomyocyte renewal is too low to efficiently counteract substantial cell loss caused by cardiac injur
195 While autophagy restoration effectively counteracts such disorders, it also exacerbates the inci
196 hat NRP proteins regulate gene expression by counteracting SWR1, thereby preventing excessive accumul
198 aling must be controlled harmoniously by two counteracted teams including (1) auxin/indole-3-acetic a
199 hogenesis are harmoniously controlled by two counteracted teams including (1) auxin/indole-3-acetic a
201 ng and is critical to exploring therapies to counteract the aplastic anemia for the treatment of FA p
202 looking for new antiviral compounds aimed to counteract the COVID-19, a disease caused by the recentl
206 compensatory mechanisms that can temporarily counteract the effects of ongoing neurodegeneration.
207 Each of these components has been shown to counteract the effects of the classical renin-angiotensi
210 TANCE A critical function of HIV-1 Vif is to counteract the family of APOBEC3 innate immune proteins.
211 n extracellular P(i) buffer which appears to counteract the gradient required for P(i) diffusion.
215 t have independently acquired the ability to counteract the ISR at its very core by acting as a compe
216 gate the side effects of pharmaceuticals and counteract the life threatening effects of drugs of abus
218 AF mutations alter interactions with ATP and counteract the negative effects of ATP binding by loweri
219 at Acid Ceramidase (AC) overexpression would counteract the negative effects of elevated ceramide and
220 Beetroot puree resulted more appropriate to counteract the negative sensations induced by UG phenols
224 event swelling and vacuolization, nor did it counteract the toxic effects of alkaloids on the parasit
225 a steeper GSA and auxin transport inhibitors counteracted the CEP receptor mutant's steep GSA phenoty
226 sed junctional "linearity" (i.e., stability) counteracted the double-hit effect on neutrophil TEM.
232 and associated carbon input to the SOC pool counteracted the increased decomposition in the adaptati
233 ong single and binary cultures, fermented-AP counteracted the inflammatory processes and the effects
235 c administration of haloperidol or clozapine counteracted the reduction of striatal A(2A)R-D(2)R hete
236 th drier climatic conditions, to some extent counteracting the climate-driven shift towards wetter co
238 margin, increasing cell cohesion and thereby counteracting the effect of mitotic rounding on contact
239 HPC ghrelin signaling increases meal size by counteracting the efficacy of various gut-derived satiat
240 y roles in neuromuscular function, including counteracting the expression of neonatal isoforms induce
242 ction over time, which has the potential for counteracting the increasing flood risk associated with
243 factor but also promotes differentiation by counteracting the negative influences of protein kinase
244 ated status of cell-based therapies aimed at counteracting the skeletal and cardiac myopathy present
245 mperature as the inverse of T(4) , precisely counteracting the T(4) dependence; hence, thermal radian
247 and impairs type I IFN signaling; BGLF2 also counteracts the ability of IFN-alpha to suppress EBV rea
250 iferation of MCF7 breast carcinoma cells and counteracts the decrease in cell proliferation and colon
251 ur results suggest that cholinergic activity counteracts the effect of GABA with regards to interocul
253 imate lentiviruses encode a Vif protein that counteracts the host antiviral APOBEC3 (A3) family membe
255 ex disorder with no effective treatment that counteracts the memory deficits and the underlying synap
257 discover that the microglial IL-10 receptor counteracts the pro-inflammatory effects of TNF to allow
258 This augmented mitochondrial Q(6) content counteracts the respiratory deficiency and lipid peroxid
259 lomerase is a ribonucleoprotein complex that counteracts the shortening of chromosome ends due to inc
260 sponses on respiratory allergen exposure and counteracts the Th2 priming effect of CysLT1R signaling
261 ens out fitness across environments and thus counteracts the variation in associated ecological patte
262 e promoter regions of PGC1alpha and PPARD to counteract their upregulation driven by HDAC1/-2 inhibit
263 cessing memories during sleep not only helps counteract their weakening but also supports problem sol
266 nst blood-feeding arthropods which, in turn, counteract these cells by modulating their biological ac
268 lenge requires host mechanisms to detect and counteract these pathogen-specific virulence strategies.
271 inhibitor and an allosteric CXCR4 inhibitor counteract this function, revealing its specificity.
276 inhibitors, acting on tumor vascularization, counteract this tumor-host energy imbalance, with signif
283 rcuits, whereas excessive opioid consumption counteracts this effect and may impair metabolic functio
284 izes ARE-containing RNAs, we found that RRM3 counteracts this effect, as shown in a cell-based ARE re
287 p2 confines Pol II and Top1 at coding units, counteracting transcription leakage and aberrant hybrids
288 o the tumor stroma was able to significantly counteract tumor growth in vivo with a significant reduc
290 nstruct immune cells to support, rather than counteract, tumor malignancy, via cell-cell contact or s
291 Irreversible blockade of MORs in the VTA counteracted two drug-seeking behaviors, locomotor activ
293 g suggests that insects can react rapidly to counteract vertical air movements and this mechanism exp
294 h deforms the nucleus, which cells initially counteract via a calcium-dependent nuclear softening dri
299 orsal sloping caused by the sacrum had to be counteracted with further skeletal modifications, e.g. a