ライフサイエンスコーパス: covalent binding

1 and suggested one biochemical mechanism for covalent binding.

2 at the recognition site are not involved in covalent binding.

3 ctive site with modest affinity, followed by covalent binding.

4 ed that these pretreatments did not decrease covalent binding.

5 uggesting that lysine binding may facilitate covalent binding.

6 ive intermediate and result in lower rate of covalent binding.

7 therefore, directly promoting host-virus non-covalent binding.

8 evelops through C797S mutation that prevents covalent binding.

9 n addition-elimination mechanism promoted by covalent binding.

10 were introduced to specific biomolecules by covalent binding.

11 f immobilization; electrostatic assembly and covalent binding.

12 nd E3 components to the E2p core through non-covalent binding.

13 ast, the FTUCAs did not exhibit any apparent covalent binding.

14 is dependent on FAD binding to Sdh1 but not covalent binding.

15 r to facilitate essentially irreversible DNA covalent binding, a geometric advantage not afforded by

16 isplatin, shows significantly more rapid DNA covalent-binding activity compared to its parent complex

17 eta-93 cysteinyl residue of HbO(2) to form a covalent-binding adduct responsible for the broad spectr

18 nding free energy and the overall reversible covalent binding affinity using a two-state binding mode

19 Covalent binding also reduces the thermal activation ene

20 ergenicity of tropomyosin by covalent or non-covalent binding, altering its secondary structure (2.1

21 but exposure to H(2)O(2) results in complete covalent binding and a fully active protein.

22 rotein adducts at 2 hours, a time of maximal covalent binding and before hepatocyte lysis, indicated

23 tion event is not solely dictated by the non-covalent binding and might be influenced by a unique seq

24 The direct covalent binding and the detailed characterization of th

25 pling of the traditional association between covalent binding and toxicity, and suggest that the asse

26 mall set of molecules also demonstrated that covalent binding and/or geometrical constraints to the l

27 iated by an initial metabolic activation and covalent binding, and subsequent activation of macrophag

28 actors include metabolism, bioactivation and covalent binding, and the inhibition of key cell functio

29 Our findings support bacterial-encoded covalent binding as a new molecular principle in host-mi

30 cation of soft organic electrophiles through covalent binding at its cysteine (Cys) thiol group, foll

31 Optimal conditions to get Tyr-Tyr covalent binding between invertase and the support were

32 The formation of covalent binding between NaCS and SSPS and structural ch

33 is is likely to be related to the absence of covalent binding between probe, sample, and substrate in

34 This study demonstrated that non-covalent binding between protein and polyphenol in the a

35 ACA allows for covalent binding between proteins and elastomers and thu

36 that the mechanism of toxicity is due to the covalent binding between the DNA methyltransferase (Dnmt

37 ane) after chemical treatments evidenced the covalent bindings between these DDXs and the organic mat

38 XIXIT docking site, which may be assisted by covalent binding but depends on other specific features

39 rt SAM to incubations of tamoxifen inhibited covalent binding by 17-23%.

40 onclusion, the findings demonstrate a novel, covalent binding by Lp(a) which is kringle independent a

41 , essentially overcame the inhibition of the covalent binding by SAM.

42 y specific assay protocols to evaluate their covalent binding capabilities, with the goal of identify

43 PS Intein-based systems enable light-induced covalent binding, cleavage, and release of proteins for

44 ging but necessary step in understanding how covalent binding could lead to liver toxicity.

45 tabolites associated with or responsible for covalent binding could not be detected, likely due to th

46 less lipophilic head heterocycles devoid of covalent binding (CVB) liability.

47 Consistent with the covalent binding data, the VIP-CRA inhibited catalysis b

48 tor (mitochondria with severe GSH depletion, covalent binding) directly inhibited respiration.

49 This non-covalent binding does not change the linking number of t

50 l time in vivo receptor occupancy (RO) for a covalent binding drug in blood lysate.

51 ng specificity and molecular interactions of covalent binding drugs in a cellular environment.

52 Determining which of these covalent binding events affect protein function, however

53 he covalent complex involving an initial non-covalent binding followed by a nucleophilic attack by th

54 ) were immobilised by entrapping and also by covalent binding for use in synthesis of isoamyl acetate

55 Covalent binding has been demonstrated for CYP4A1, -4A2,

56 metabolites that could explain the in vitro covalent binding in microsomes observed across the speci

57 tigate the hepatotoxicity; however, only the covalent binding in rat, dog, and human microsomes was i

58 The extent of heme covalent binding in the proteins as isolated varies and

59 ibodies and DNA, which undergo important non-covalent binding interactions, with the formation of ant

60 eitol, suggesting an involvement of cysteine covalent binding interface.

61 oquinone derivatives that function as potent covalent-binding, irreversible inhibitors of the kinase

62 concave surface of [60]fullerene, endohedral covalent binding is possible inside a (5,5) SWNT despite

63 chnique is proven in its capacity to confirm covalent binding, it does not provide binding site infor

64 7328948, which was largely devoid of protein covalent binding liability.

65 ly encoded electrophiles for mRNA display of covalent binding ligands and identifies potent new probe

66 An irreversible covalent binding mechanism imparts many desirable pharma

67 at was irreversible after washout due to the covalent binding mechanism.

68 iles that exhibit irreversible or reversibly covalent binding mechanisms towards cysteine thiols and

69 pounds presented herein display an efficient covalent binding mode and that the respective covalent l

70 Computational modeling suggested a novel covalent binding mode in active-site CGHCK motifs.

71 The covalent binding mode of compound 4 to PRMT6 was confirm

72 The covalent binding mode was validated by mass spectrometry

73 smon resonance analysis demonstrated its non-covalent binding mode.

74 ates have recently been published as well as covalent binding modes for electrophile agonists.

75 modeling indicated that both noncovalent and covalent binding modes were theoretically possible.

76 articularly relevant for PROTACs that harbor covalent binding moieties.

77 on theory shows that QUID broadly covers non-covalent binding motifs and energetic contributions.

78 resent paper describes the assessment of non-covalent binding (NCB) between milk proteins and polyphe

79 tors overcome this resistance simply through covalent binding, not as a result of an alternative bind

80 The unexpected covalent binding observed in the PGA-DON and PGA-DONV co

81 The covalent binding occurred preferentially at the light ch

82 favoring an ionic pre-adsorption step before covalent binding occurred.

83 ric oligonucleotide adducts derived from the covalent binding of (+/-)-anti-7r,8t-dihydroxy-9t,10-epo

84 a modification of the protein indicative of covalent binding of 2-aminothiazole.

85 bout 160 of the new products were formed via covalent binding of 3-QCA with DOM molecules of above-av

86 mass spectrometry, we have demonstrated the covalent binding of 4-HNE to Daxx.

87 By contrast, covalent binding of 4-hydroxytamoxifen (4-OH-tam) was 3-

88 fied, such as pyocyanin, we propose that the covalent binding of 5MPCA promotes its accumulation in t

89 Accumulation and covalent binding of [(14)C]1a derived radioactivity was

90 Neither CYP2E1 levels nor covalent binding of [14C] CCl4-derived radio-label diffe

91 Ala, Arg, His, and Leu completely eliminated covalent binding of [3H]beta-FNA, although these mutants

92 of other amino acid residues did not affect covalent binding of [3H]beta-FNA.

93 d residue of the mu receptor involved in the covalent binding of [3H]beta-FNA.

94 The assay monitors prevention of covalent binding of a fluorescence turn-on probe to a cy

95 escence, and cysteine mutagenesis coupled to covalent binding of a membrane-sensitive probe showed th

96 e of bulky adducts that are generated by the covalent binding of a variety of metabolically activated

97 glutathione conjugates, or in the levels of covalent binding of acetaminophen-reactive metabolites t

98 step of epidermal lipid barrier formation by covalent binding of acylceramide to the cornified envelo

99 -ATP monolayers previously oxidized, and the covalent binding of amino-oligonucleotides to pure p-MBA

100 y of proteins which act via an ATP-dependent covalent binding of AMP to their substrates and shows th

101 P1A1 mRNA and CYP1A1/1A2 protein followed by covalent binding of an AF metabolite to DNA, phosphoryla

102 the first crystallographic demonstration of covalent binding of an enzyme by borate.

103 represents a valuable moiety that can induce covalent binding of an inhibitor to its target.

104 Minor adducts, derived from the covalent binding of anti-benzo[a]pyrene-7,8-dihydroxy-9,

105 Covalent binding of Anti-Cab onto Ag@AgO-PANI nanocompos

106 confined carboxyl groups suitable for direct covalent binding of anti-IGF1 monoclonal antibody.

107 in the cellular environment, preventing the covalent binding of ARS-853.

108 tegies to fortify their capsids, such as non-covalent binding of auxiliary 'decoration' (Dec) protein

109 Transglutaminase-catalyzed covalent binding of bioactive peptides targeted to miner

110 idase and holocarboxylase synthetase mediate covalent binding of biotin to histones (DNA-binding prot

111 protein that is essential for mediating the covalent binding of biotin to histones.

112 theory calculations unveil versatile dynamic covalent binding of boronic ester with various hydroxy-t

113 Additionally, for the first time a covalent binding of both drugs with hTTR was identified

114 The covalent binding of bulky mutagenic or carcinogenic comp

115 In dimeric NIR FPs without Cys15, the covalent binding of BV to capital ES, Cyrillicys256 in o

116 6 in one monomer allosterically inhibits the covalent binding of BV to the other monomer, whereas the

117 Covalent binding of capturing biomolecule (anti-TNF-alph

118 hese products were presumably formed through covalent binding of CBZ phototransformation products wit

119 unclear, this oxidation pathway promotes the covalent binding of ceramides to protein, forming a crit

120 limination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to the

121 acid (DAP), which upon photodecaging enables covalent binding of DAP to the PET surface.

122 r sulfonic acid) ionomer Eastman AQ38S or by covalent binding of DNA onto oxidized PG.

123 A procedure for covalent binding of DNA to a functionalized mica substra

124 it the fibrillation of alpha-Syn, due to non-covalent binding of DOPAC to alpha-Syn monomer.

125 the allergic-immune mechanism relies on the covalent binding of drugs/chemicals to proteins, which t

126 Covalent binding of endo- or exogenous chemicals to DNA

127 Molecular docking results predicted covalent binding of erlotinib, O-desmethylerlotinib, and

128 regard to functional significance of 8alpha-covalent binding of flavins to proteins.

129 in and immunoglobulin G-antibody) as well as covalent binding of fluorescently tagged bovine serum al

130 o alter the chromatin structure inducing the covalent binding of genomic DNA with proteins, a feature

131 sly found to modify apolipoprotein B100 with covalent binding of Hb fragments and formation of electr

132 LC-MS revealed the covalent binding of HNE to Mb at both pH values via Mich

133 Covalent binding of IDAM to cellular macromolecules and

134 This effect is mediated by covalent binding of iRGD to plasma albumin through a dis

135 Non-covalent binding of K63-Ubn to 2CARD induces its tetrame

136 Covalent binding of L-764406 was proven by an observed m

137 ected in the alpha subunits by the rapid and covalent binding of Lucifer Yellow vinyl sulfone (LY) to

138 MCF-7 cells, 4'BF significantly reduced the covalent binding of metabolically activated benzo[a]pyre

139 Specific non-covalent binding of metal ions and ligands, such as nucl

140 d the beta-branched Val(166), disrupting the covalent binding of NIR to the catalytic Cys(145) and le

141 netics of isoindole formation resulting from covalent binding of NNA to wild-type and mutant opioid r

142 ere we describe a detailed protocol based on covalent binding of nucleophilic groups on Wnt proteins

143 Recently, mass spectrometry identified covalent binding of OPs to tyrosine in a wide variety of

144 p-type sensitization of TiO2 solely based on covalent binding of organic adsorbates.

145 The covalent binding of organosulfur compounds to beta-lacto

146 As no covalent binding of oxygen to the metal occurs in the zi

147 The covalent binding of PA to the N-terminus of the RabGGTas

148 olecular superhydrogenation which favors the covalent binding of PAHs in a thermally activated proces

149 tions and wobble base pairing induced by the covalent binding of POB to the O(6)-position of dG help

150 The biological implications of non-covalent binding of polyphenols to BLG were investigated

151 ons imply that transglutaminases may mediate covalent binding of pro-CpU to other proteins and cell s

152 We hypothesized that the covalent binding of proanthocyanidin (PC) to soybean mea

153 e grafting of poly(acrylic acid) followed by covalent binding of protein A/G enabled efficient captur

154 We demonstrate the covalent binding of protein-repellent thin films to the

155 The effects of covalent binding of protocatechuic acid (PA) and gallic

156 A DdlR mutation that prevented covalent binding of pyridoxal 5'-phosphate abolished the

157 These investigations characterize the covalent binding of reactive products of prostaglandin H

158 ed wild-type apoprotein folding, but altered covalent binding of retinal and final folding to bacteri

159 nd the FG loop to that for final folding and covalent binding of retinal.

160 signed preactivated IFO derivatives with the covalent binding of several O- and S-alkyl moieties incl

161 Proteolytic inhibition requires covalent binding of STC2 to PAPP-A and is mediated by a

162 The rate of covalent binding of tamoxifen metabolites, tamoxifen N-o

163 ascorbic acid and glutathione, inhibitors of covalent binding of tamoxifen, produced an elevation of

164 genesis, and molecular modeling, we show the covalent binding of thalassospiramide's alpha,beta-unsat

165 changes in the metal permittivity following covalent binding of the adsorbate layer.

166 In contrast, induction of CYP1A1 and covalent binding of the AF metabolite did not occur in A

167 Covalent binding of the AF metabolite was increased by p

168 -based irreversible inhibitor of cAD through covalent binding of the alkyl chain to the enzyme.

169 sign ADCs that self-assemble through the non-covalent binding of the antibody to a payload that we de

170 Whereas APAP-bioactivating enzymes and covalent binding of the APAP-derived reactive metabolite

171 ate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BFA-ADP-ribose conjugate into th

172 We have characterized the covalent binding of the CO(2) reduction electrocatalyst

173 The biosensor was constructed by covalent binding of the enzyme substrate d-fructose 6-ph

174 2D 1H-1H NMR TOCSY provided evidence of covalent binding of the europium analog of the C-6 compo

175 n ester bond to the heme 5-methyl group, (b) covalent binding of the heme is mediated by an autocatal

176 doxin reductase, and NADH results in partial covalent binding of the heme to the protein.

177 talyst and organic hydroperoxide as oxidant, covalent binding of the hydroperoxide is not required, a

178 This study confirms the irreversible covalent binding of the inhibitor to the kinase by x-ray

179 eaction mechanism could be inferred from the covalent binding of the proteasome-specific inhibitor ep

180 Ubiquitination, the covalent binding of the small protein modifier ubiquitin

181 In the case of carmofur and X77A, the covalent binding of the thiolate to the ligand is accomp

182 The electron density map displays covalent binding of the Thr1O(gamma) atoms of all active

183 ctive form of the DD-peptidase shows the non-covalent binding of the two products of the carboxypepti

184 hese effects are thought to be caused by the covalent binding of these species to nucleophilic groups

185 bon nanotubes/gold nanoparticles followed by covalent binding of tyrosinase.

186 Covalent binding of ubiquitin to proteins marks them for

187 ding ligases called E3s, that coordinate the covalent binding of ubiquitin to target proteins.

188 the ATMS/diazotization chemistry facilitated covalent binding of unmodified DNA, and the reusable mic

189 Mass spectrometry demonstrated direct covalent binding of WA to Cys(303) of beta-tubulin in MC

190 consequence of blocking the stimulatory, non-covalent, binding of ubiquitin to the backside of UbcH5B

191 tter through the pironetin end (irreversible covalent binding) or through the colchicine end (reversi

192 f the human proteome to characterize the non-covalent binding PARylome.

193 In this proof-of-concept study, the use of a covalent binding peptide ligand against VEGF improves tr

194 ts new opportunities in using artificial non-covalent binding pockets as highly tunable and selective

195 elastase inhibitors, which offer reversible covalent binding properties.

196 e current methodology for the measurement of covalent binding relies on the use of radiolabeled mater

197 n P450 enzymes, but also show that efficient covalent binding requires placement of the carboxyl clos

198 n general, can be used to predict reversible covalent binding selectivity.

199 t3p cannot bind concurrently to both the non-covalent binding site and the catalytic cysteine of a si

200 was used for systematic mapping of potential covalent binding sites available in human histone deacet

201 sites for allicin, whereas the number of non-covalent binding sites increased for diallyl disulfide.

202 roducing appropriate feature annotations for covalent binding sites, modified sites and cross-links.

203 We conclude that covalent binding state alone, in general, can be used to

204 on warhead scaffold, in both noncovalent and covalent binding states, and for two highly homologous p

205 3A4 and human liver microsomes resulted in a covalent binding stoichiometry equal to 0.93 +/- 0.04 mo

206 a poly(ethylene glycol) (PEG) host as a non-covalent binding strategy for surface functionalization.

207 s diffusion electrodes (GDEs) by using a non-covalent binding strategy.

208 tive metabolite formation was evaluated in a covalent binding study to assess its irreversible bindin

209 as also comparable, as determined by using a covalent-binding suicide substrate.

210 A stable covalent binding technique for lipase enzyme immobilizat

211 n APAP bioactivation results in less-intense covalent binding that is more diffuse and spread uniform

212 alcohol dehydrogenase enzyme immobilised by covalent binding through an array composed of carbon Tor

213 nticancer drug, which triggers cell death by covalent binding to a broad range of biological molecule

214 mic nature of the bullvalene core allows for covalent binding to a wide variety of analytes, allowing

215 tion as immunomodulators, apparently through covalent binding to albumin.

216 zed by two key molecular properties: (1) non-covalent binding to an antibody-based therapeutic, and (

217 ed form by sensitive cell lines only and its covalent binding to an intracellular protein.

218 Target occupancy is a measure of covalent binding to BTK and has been applied as a pharma

219 (dimethylamino)propanamide (5), did not show covalent binding to cell-free EGFR-TK in a fluorescence

220 than SFN, these results indicate that direct covalent binding to cellular proteins is an important ea

221 study using mass spectral analysis confirmed covalent binding to Cys249 within the PPARdelta binding

222 d CHO), yet they do not show any evidence of covalent binding to DNA.

223 Drug covalent binding to endogenous proteins (haptenation) is

224 Tyr-398 in MAO B may be involved in the non-covalent binding to FAD.

225 atures a photoreactive moiety for UV-induced covalent binding to GSTs and GSH-binding enzymes.

226 n of the cytochrome c1 cysteines involved in covalent binding to heme nearly abolished immunodetectab

227 timate reactive intermediate that results in covalent binding to microsomal proteins.

228 However, the effect of non-covalent binding to Nedd8 remains unknown.

229 or groove but 1 must diffuse off the DNA for covalent binding to occur.

230 AD was increased further by about 75 mV upon covalent binding to PchF, i.e., PchF(C).

231 interrupt platelet-cancer interplay through covalent binding to PDI catalytic active site.

232 ng release of free omega-hydroxyceramide for covalent binding to protein and sealing of the waterproo

233 of a reactive metabolite which demonstrated covalent binding to protein in vitro.

234 nd, releasing free omega-hydroxyceramide for covalent binding to protein, thus forming the corneocyte

235 be used to release conjugated molecules upon covalent binding to proteins and could be used to develo

236 folding through covalent modification or non-covalent binding to target proteins.

237 res of GSTO1 with our inhibitors demonstrate covalent binding to the active site cysteine.

238 pound to inhibit fatty acid biosynthesis via covalent binding to the active site of Chlamydia FabH, i

239 tabilization of tetrahedral intermediates by covalent binding to the electrophilic CO(2).

240 -containing C terminus that does not require covalent binding to the membrane domain of ClC-7.

241 ucleophile (CN-), which fluoresces only upon covalent binding to the protein.

242 rate-limiting step of glycolysis through its covalent binding to the pyruvate kinase M2 (PKM2) enzyme

243 ATP competes with regular DNA for non-covalent binding to the T4 ligase and is found to signif

244 The covalent binding to the targeted proteins was confirmed

245 conjugate addition-elimination reaction upon covalent binding to their target cysteine allows functio

246 (64)Cu-L19K-FDNB was assayed for covalent binding to VEGF in vitro.

247 may be employed in design of the switchable covalent-binding tool, activated by chemical or enzymati

248 t were identified and then optimized for non-covalent binding using structure-based design.

249 Covalent binding via reaction of one amine group to a bo

250 Covalent binding was achived with Chi modified with spac

251 Covalent binding was attenuated when Lp(a) was pretreate

252 Covalent binding was inhibited when Lp(a) was mildly oxi

253 Significantly greater GSH loss and APAP covalent binding were observed in liver slice mitochondr

254 st non-fluorescent chemical probe has a fast covalent binding with carbonyl moieties at neutral pH to

255 UALs exhibited significant levels of protein covalent binding, with binding levels ranging from 20.1