ライフサイエンスコーパス: covalently

1 dehyde substituted poly(phosphazene) (P-PHP) covalently.

2 terization identified 2 to bind the receptor covalently.

3 ylate-based reference membranes are attached covalently.

4 d due to protein's inability to bind targets covalently.

5 al interactions or be chemically modified to covalently accommodate cargos.

6 emonstrated that surface-associated InlB non-covalently adheres to both WTA and LTA, mediating its re

7 Drugs that target KRAS 12C covalently, AMG 510 and MRTX849, are now in the clinic.

8 te adhesion by variants of full-length FnBPA covalently anchored in the outer cell wall of Lactococcu

9 ine-encapsulating nanoparticles that are non-covalently anchored onto the surface of injected erythro

10 s (ILs) capable of complexing with siRNA non-covalently and delivering it effectively.

11 frameworks constructed from coordinatively, covalently, and noncovalently linked building units.

12 We study the effect of covalently appended fluorous tags on the cyanine scaffol

13 te that modulating a base-metal center via a covalently appended Lewis acidic support is viable for p

14 TLF2 also uniquely contains non-covalently associated immunoglobin M (IgM) antibodies, t

15 lational autoproteolysis to generate two non-covalently associated polypeptide chains.

16 ed using intricate chemical methodologies to covalently attach purified polysaccharides to carrier pr

17 ors tranylcypromine (TCP) and OG-L002, which covalently attach to the LSD1 cofactor flavin adenine di

18 ymer scaffold, poly(beta-L-malic acid), with covalently attached a-CTLA-4 or a-PD-1 for systemic deli

19 face functionalization with amine groups and covalently attached biotin, the device has been applied

20 alkyl chain lengths (PC_C14 and PC_C16) and covalently attached caffeic acid on the physical and oxi

21 ATEMs with different length (C12 or C14) and covalently attached caffeic acid.

22 We covalently attached human immunodeficiency virus type 1

23 er leaflet of the plasma membrane (PM) using covalently attached lipid anchors.

24 Ion-selective membranes with covalently attached or freely dissolved ionophore- and i

25 Oxygen reduction by iron porphyrins bearing covalently attached pendant phenol and quinol groups is

26 In this manuscript, we covalently attached Rose Bengal (RB) to the amphipathic

27 t dyes (sarcosine-VoltageFluors) that can be covalently attached to a genetically encoded cell surfac

28 These OrX/Orco liposomes were covalently attached to a gold surface modified with N-hy

29 two homologous "heavy chains" (HC1 and HC2) covalently attached to chondroitin sulfate on the bikuni

30 Electron density shows the inhibitors covalently attached to His57 of the catalytic triad.

31 , here cyclic oligochalcogenides (COCs), are covalently attached to lysines of wild-type streptavidin

32 PG to show that beta-barrel OM proteins are covalently attached to PG in several Gram-negative speci

33 on emission from fluorescent reporter groups covalently attached to specific positions in the recepto

34 trahedral intermediate that is uncleaved but covalently attached to the catalytic serine, about which

35 r consists of a Stem-Loop DNA (SL-DNA) probe covalently attached to the gold electrode (GE) surface t

36 e short, monodisperse oligodimethylsiloxanes covalently attached to the headgroups.

37 oups, or phycoerythrobilins (PEBs), that are covalently attached to the protein chain by specific bil

38 is often far from the C-H bond, and both TDG covalently attached to the substrate and free TDG are ca

39 scopy (AFM) revealed that the liposomes were covalently attached to the surface without any disruptio

40 plexes and analyzed E2 interactions with the covalently attached Ub and Ub(2) moieties using NMR spec

41 o surface ligands under low force and remain covalently attached under mechanical stress.

42 s show that MpeV is the lyase isomerase that covalently attaches a doubly linked phycourobilin to two

43 odification in which a long chain fatty acid covalently attaches to specific cysteine(s) of proteins

44 glyoxal, a well-characterized compound that covalently attaches to the Watson-Crick-Franklin face of

45 cle control and an expanded role for Ldts in covalently attaching surface proteins to PG.

46 The taccalonolide microtubule stabilizers covalently bind beta-tubulin and overcome clinically rel

47 of the methanogenic energy metabolism is to covalently bind C(1) species to the C(1) carriers methan

48 Molecules that covalently bind macromolecular targets have found widesp

49 a second reactive site (imidazolide) and can covalently bind to amino acids other than cysteine on ta

50 highly potent reactive small molecules that covalently bind to PDI.

51 ed to cells, RhoVR-Halo dyes selectively and covalently bind to surface-expressed HaloTag enzyme on g

52 ding SL, it hydrolyzes the hormone, and then covalently binds one of the hydrolytic products.

53 id (LA) is a sulfur-containing cofactor that covalently binds to a variety of cognate enzymes that ar

54 iscovery approach identified a compound that covalently binds to and irreversibly inhibits the activi

55 cture of NfoR-Cu(II) complex is a dimer that covalently binds with FMN and Cu(II)-binding pocket is l

56 f factor X to Xase assembled with IXa with a covalently blocked active site.

57 We showed that while 1D chain of covalently bonded (I,n,Te2)n-n transport heat with Debye

58 coordination number, a realistic feature of covalently bonded amorphous solids.

59 ges for fast Li(+) entry; the coating of the covalently bonded BP-graphite particles with electrolyte

60 ent electron acceptor, these quinone species covalently bonded on the surface of dual-emission amino-

61 ides a route for the production of 1D and 2D covalently bonded polymeric structures.

62 tion 2, hydrogen bonded tannins; fraction 3, covalently bonded tannins), especially at harvest.

63 o an ohmic contact when a single molecule is covalently bonded to both silicon and gold electrodes.

64 covalent organic frameworks (COFs)-extended, covalently bonded, and porous structures-have been reali

65 ecules and residues in protein sequences are covalently bonded.

66 odular polymer nanoformulation that protects covalently bound CPT until slowly being released over ex

67 the structure of the CAK in complex with the covalently bound inhibitor THZ1 in order to provide insi

68 ermined with glucuronate, in both native and covalently bound intermediate states, and galacturonate

69 cked in an inactive state in the dark by the covalently bound inverse agonist 11-cis retinal.

70 ure of the protease domain in complex with a covalently bound leader peptide demonstrates the basis f

71 hallenge due to the exchange dynamics of non-covalently bound monomers and hence requires fine micros

72 amperometric genosensor based on PNA probes covalently bound on the surface of Single Walled Carbon

73 ain tandem construct comprising two distinct covalently bound PDZ domains belonging to a protein call

74 ique characteristics of its light-sensitive, covalently bound retinal ligands.

75 chemistry and advanced catalyst design, and covalently bound spectator substituents to stabilize rad

76 ear tetrapyrroles as chromophores, which are covalently bound to a cysteine (Cys) residue in the chro

77 body-drug conjugate comprised of trastuzumab covalently bound to a linker drug containing duocarmycin

78 ng vaccines, wherein an antigenic peptide is covalently bound to an immunostimulating agent, have bee

79 a) is composed of apolipoprotein(a) (apo(a)) covalently bound to apolipoprotein B of low-density lipo

80 t the carbonyl reactive group of carmofur is covalently bound to catalytic Cys145, whereas its fatty

81 ree discrete reaction intermediates that are covalently bound to CTQ during the reaction, two of whic

82 e catalyst consisting of atomic cobalt array covalently bound to distorted 1T MoS(2) nanosheets (SA C

83 Subsequently, TOP2 remains covalently bound to each end of the enzyme-bridged DSB,

84 These cofactors consist of an ADP core covalently bound to extra moieties.

85 .730 and 1.998 mg.g(-1) of chlorogenic acids covalently bound to helianthinin and albumins in aqueous

86 Starting from a mutant that remains covalently bound to its substrate RNA (E358Q, TrmA*), we

87 elianthinin and albumins), chlorogenic acids covalently bound to proteins, and free chlorogenic acid

88 -Man-(1 -> and -> 6)-alpha-Gal-(1 -> chains, covalently bound to proteins.

89 derived viral genome-linked protein (VPg) is covalently bound to the 5' end of viral genomic RNA (gRN

90 of its receptors on a chip, and (iii) gD is covalently bound to the chip surface.

91 functionalized with fluorescent tags, often covalently bound to the disordered N-terminus region of

92 xtended 10-20-mer peptides (RA) (n) AAKKKYCL covalently bound to the human leukocyte antigen (HLA)-B*

93 al specific cell adhesion molecule, has been covalently bound to the neural electrode array surface.

94 ly organic porous crystalline materials with covalently bound two- and three-dimensional acceptors.

95 uctures of the human MLKL executioner domain covalently bound via Cys86 to a xanthine class inhibitor

96 a complex process that involves removing the covalently bound viral polymerase from rcDNA, which prod

97 previously demonstrated that, despite being covalently bound, ATR can display properties of equilibr

98 izes a library of photoreactive fragments to covalently capture fragment-protein interactions.

99 We show that this method can be used to covalently capture intermediate transport states of Lipi

100 Circular RNAs, a family of covalently circularized RNAs with tissue-specific expres

101 Since the viral genome exists as a covalently closed circle of double-stranded DNA, topoiso

102 Hepatitis B virus (HBV) covalently closed circular (ccc)DNA is the key genomic f

103 e in curing HBV is eradication of the stable covalently closed circular DNA (cccDNA) form of the vira

104 Covalently closed circular DNA (cccDNA) forms the basis

105 nome, which is subsequently converted into a covalently closed circular DNA (cccDNA) in the host cell

106 ination and cccDNA biogenesis.IMPORTANCE The covalently closed circular DNA (cccDNA) is the persisten

107 Covalently closed circular DNA (cccDNA) of hepadnaviruse

108 The biosynthesis of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) requires the rem

109 virus because the transcriptional template, covalently closed circular DNA (cccDNA), is long lived i

110 tigen (HBcrAg) as surrogates of silencing of covalently closed circular DNA (cccDNA), to characterize

111 C1) to circularized HBV DNA (which resembles covalently closed circular DNA [cccDNA]).

112 active intrahepatic HBV reservoir (circular covalently closed DNA, relaxed circular DNA, and pregeno

113 wall hydrolases are required to enlarge this covalently closed macromolecule during growth, but how t

114 ibitor treatment prevented the production of covalently closed negative-strand rcDNA, TOP2 inhibitors

115 Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process n

116 Circular RNAs (circRNAs) are covalently closed RNAs derived from back-splicing of gen

117 are a distinct category of single-stranded, covalently closed RNAs formed by backsplicing.

118 are an intriguing class of RNA due to their covalently closed structure, high stability, and implica

119 Circular RNAs (circRNAs) are a covalently closed subclass of non-coding RNA molecules f

120 Strikingly, incision of covalently closed, relaxed loop-containing DNA by human

121 These shuttle peptides, non-covalently combined with GFP protein or CRISPR-associate

122 Additionally, AftD is non-covalently complexed with an acyl carrier protein (ACP).

123 f 1400 receptors per mum(2) represented by a covalently conjugated TIL region from the beta1-adrenerg

124 When covalently conjugated to alendronate, YLLs acquire an ad

125 The assay consists of haptens covalently conjugated to fluorescence-encoded polystyren

126 ene nanoparticle core with silver nanoshells covalently conjugated to HSA antibodies), and these nano

127 le ubiquitin-like modifier FAT10, which gets covalently conjugated to hundreds of proteins and target

128 ry and population distribution of antibodies covalently conjugated to the surface of a bacteriophage

129 from Mycobacterium tuberculosis (Mtb), were covalently conjugated to the TLR2-ligand Pam(2)Cys to ge

130 In addition, KH-1 covalently conjugated with anthracycline anticancer agen

131 ndent sites on a drug hapten-specific Ab and covalently conjugates only to the specific IgE, permanen

132 eral synthetic method creates a new class of covalently connected, self-threaded, fluorescent molecul

133 iral material into an achiral soft system or covalently connecting photochromic moieties to the molec

134 such that multiple unique oligomers bearing covalently coreactive pendant groups are able to undergo

135 The surface confined template and covalently coupled reaction products are investigated an

136 The vaccine consisted of eIL-31 covalently coupled to a virus-like particle (VLP) derive

137 This functional moiety was covalently coupled to an acrylate monomer via a facile t

138 arrier consists of mouse serum albumin (MSA) covalently coupled to several PDGFbetaR-recognizing moie

139 igh-density deposition of carboxyfluorescein covalently coupled to silica microspheres shows an inver

140 Dodecanoic acid was covalently coupled to the alpha/epsilon-amino group of o

141 Silica microspheres covalently coupled with a high density of ratiometricall

142 trosourea and 8-methoxypsoralen, are used to covalently cross-link interstrand base pairs in DNA bond

143 xymethylcytosine-binding protein (HMCES) can covalently cross-link to abasic sites in single-stranded

144 keleton is composed of repeating saccharides covalently cross-linked by peptide stems.

145 dergo a repeatable change in topology from a covalently cross-linked material into a liquid polymer f

146 An azobenzene-derived photoswitch has been covalently cross-linked to two sites of the S-peptide in

147 d microfluidic analyses, we show that FXIIIa covalently cross-links Abeta40 into dimers and oligomers

148 ivation by calcium binding/thrombin cleavage covalently cross-links preformed fibrin clots protecting

149 Activated coagulation factor XIIIa (FXIIIa) covalently cross-links proteins in blood and vasculature

150 by TET proteins, was previously reported to covalently crosslink to DNA at abasic sites via a conser

151 re distinct from those in which the original covalently crosslinked network is formed, often simultan

152 s (CANs), unlike typical thermosets or other covalently crosslinked networks, possess a unique, often

153 ing ROS nanoscavenger masked by pH sensitive covalently crosslinked polyethylene glycol.

154 Here, we test this model by covalently crosslinking ClpA to ClpP to prevent rotation

155 intramolecular transglutamination reaction, covalently crosslinking the Ube2N and Ub subunits effect

156 ographic processes, leading to unprecedented covalently doped graphene superlattices.

157 transfer radical polymerization initiator to covalently functionalize the oxide layer on the surface

158 cifically, we describe a system comprised of covalently functionalized aryl groups on graphene that u

159 in we demonstrate efficacious utilization of covalently functionalized beta-cyclodextrinylated MEMS d

160 c capacitance of carbon-based electrodes, we covalently functionalized graphene oxide with a redox ac

161 work, we demonstrate electrodes composed of covalently functionalized graphite, decorated with vario

162 re successfully fabricated, incorporated and covalently functionalized in a commercial dental adhesiv

163 These carbon materials covalently functionalized with SO(3)H groups via C-PhSO(

164 ic brushes perform significantly better than covalently grafted polyelectrolyte brushes in the presen

165 nation, we developed a bead-based assay with covalently immobilized but releasable misfolded protein

166 tric approach for glucose detection based on covalently immobilized glucose oxidase on PCB-integrated

167 d with a silatrane-anchor (STEMPO), which is covalently immobilized on a mesoporous indium tin oxide

168 The enzyme preparation was covalently immobilized on aluminum oxide pellets (3 mm)

169 PAMAM) dendrimer nanocomposite (3D-Au-PAMAM) covalently immobilized onto electrografted p-aminobenzoi

170 Herein, pectinase was covalently immobilized onto polyethylene glycol grafted

171 be immunoprobed first, even when targets are covalently immobilized to the gel.

172 r the A. minutum toxic strain AL9T, was then covalently immobilized via SpyCatcher on the surface of

173 ng electrochemical microcopy (SECM) probe by covalently immobilizing the glucose oxidase (GOD) enzyme

174 lectrodes (Tyr/ZnO-rGO/ITO) were designed by covalently immobilizing tyrosinase enzyme on spin-coated

175 Here, we demonstrate that Orsay CP-delta is covalently incorporated into infectious particles, the f

176 Since puromycin is covalently incorporated into nascent polypeptide chains,

177 ays essential roles in bacterial physiology, covalently incorporating FMN cofactors into numerous res

178 them attractive components for the design of covalently integrated hybrid organic-inorganic molecules

179 strand transfer complex with transposon ends covalently joined to target DNA, at resolutions of 3.0-4

180 We covalently labeled each lobe of CaM (N and C) with fluor

181 (pentafluorophenyl) porphyrin, TFPP) and are covalently labeled with pH-sensitive fluorescein isothio

182 nto biotin-AMP, a reactive intermediate that covalently labels proximal proteins.

183 More than 3,000 covalently liganded cysteines were found on functionally

184 Thiol-maleimide chemistry was utilised to covalently ligate the Group B Streptococcus (GBS) GBS67

185 ing, the 5' and 3' termini of exon(s) can be covalently ligated to form circRNAs through back-splicin

186 trimethoxysilane (AEAPTMS) is constructed to covalently link a dye molecular, perylene diimide deriva

187 The synthetic methodology to covalently link donors to form cyclophane-based thermall

188 ibose) polymerase (PARP) superfamily members covalently link either a single ADP-ribose (ADPR) or a c

189 hybrid-POM platforms offer an opportunity to covalently link multi-electron redox responsive POM core

190 ates an intersubunit disulfide bond (SOS) to covalently link the gp120 and gp41 ectodomain (gp41(ECTO

191 DNA interstrand crosslinks covalently link the two strands of DNA, and thereby bloc

192 l probe, which carries a photocrosslinker to covalently link virus-interacting proteins in living cel

193 osition S239 resulted in dimerization, which covalently linked antibody heavy chains together.

194 was used as a key precursor to prepare novel covalently linked azaBODIPY-based conjugates.

195 nergy transfer from the donor to acceptor in covalently linked conjugates.

196 ing E in its wild-type form or E locked in a covalently linked dimeric (cvD) conformation to enhance

197 n the electron-accepting features of CNDs in covalently linked donor-acceptor nanoconjugates.

198 oding genes generate circular RNAs that have covalently linked ends and are resistant to degradation

199 glycopeptide is bound to MHCII, allowing the covalently linked glycan to activate carbohydrate-specif

200 ACPs), small, flexible proteins that shuttle covalently linked intermediates between catalytic partne

201 to carry out in this study the formation of covalently linked nanoconjugates that feature electron-d

202 Covalently linked pai-stacked dimers represent the most

203 ectrometry draws structural information from covalently linked peptide pairs.

204 sembly and allows signal transduction to the covalently linked physiological diguanylate cyclase outp

205 en three and fifteen monosaccharide residues covalently linked through glycosidic bonds.

206 thin the concentration range tested, yet NPs covalently linked to a cationic polymer induce strong cy

207 The vaccine consisted of equine IL-5 (eIL-5) covalently linked to a cucumber mosaic virus-like partic

208 S-acylation, whereby a fatty acid chain is covalently linked to a cysteine residue by a thioester l

209 g biosensors, based on glucose oxidase (GOx) covalently linked to a single layer graphene (SLG), will

210 Cytokinins covalently linked to beads that could not pass the plasm

211 d into a 3,5-bis-triazole pyridine structure covalently linked to benzo-15-crown-5 ether motifs exhib

212 long chains of repeating disaccharide units, covalently linked to core proteins to form proteoglycans

213 of carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules.

214 system composed of CdSe/CdS core/shell QDs, covalently linked to naphthalenediimide (NDI) electron-a

215 HIP sequences derived from insulin fragments covalently linked to one another or to fragments of secr

216 (1 and 3) or three (2 and 4) pyrene anchors, covalently linked to porphyrins (free base or Zn), were

217 tes are chemotherapeutic or cytotoxic agents covalently linked to targeting ligands such as an antibo

218 to infectious particles as protruding fibers covalently linked to the capsid.

219 Hydrophobic modifications, covalently linked to the DNA, are essential for targeted

220 erent monosaccharide derivatives (7a-e) were covalently linked to the N-terminal of R-lycosin-I, whic

221 This reaction generates a fluorescent dye covalently linked to the receptor while naltrexamine is

222 Visual pigment consists of opsin covalently linked to the vitamin A-derived chromophore,

223 VHH1 is a single-domain antibody covalently linked to therapeutic (131)I via the linker N

224 previously observed for dyads containing BP covalently linked to thymidine, the aim of this work is

225 of the cIAP1 RING dimer bound to both UbcH5B covalently linked to Ub (UbcH5B-Ub) and a noncovalent Ub

226 double-strand breaks (DSBs) via a transient, covalently linked TOP2 DNA-protein intermediate, termed

227 Most of these covalently linked transcripts are expressed at low level

228 ties of the TRESK/TREK-2 heterodimer using a covalently linked TRESK/TREK-2 construct to ensure the a

229 sites: a unique [2Fe] subcluster ([2Fe](H)) covalently linked via cysteine to a canonical [4Fe-4S] c

230 lar DNA (cccDNA) requires the removal of the covalently linked viral polymerase from the 5' end of th

231 neral immunoassays, secondary antibodies are covalently linked with enzymes and bind to the Fc region

232 edox components are mechanically rather than covalently linked.

233 The successful formation of covalently-linked hexadecyl and phenyl functionalized ma

234 as the housekeeping sortase responsible for covalently linking adhesins to the cell wall.

235 ns on membrane proteins has been examined by covalently linking Cy5 to single- and multipass transmem

236 enerated an antibody-drug conjugate (ADC) by covalently linking the chimeric human mAb to the tubulin

237 nalogues, which exhibit fluorescence without covalently linking the pyrole-pyrrolidine nitrogen atoms

238 e way to deliver drugs to mitochondria is by covalently linking them to a lipophilic cation, the in v

239 rystal structure of a disulfide variant that covalently links substrate-enclosing loops on either sid

240 these uracils, we engineered a protein that covalently links to DNA at uracils, UdgX, for mammalian

241 Each RNA nanoparticle covalently loads twenty-four paclitaxel molecules as a p

242 mbinant plant light harvesting complexes are covalently locked with reaction centres from a purple ph

243 to detect "twin ions" of peptides that were covalently modified by a chemical reaction with dichlorv

244 presented, in which the gamma-phosphate was covalently modified by a non-bioreversible, lipophilic 4

245 ino acid residue sites of proteins that were covalently modified by exposure to OPs.

246 The only currently known cellular molecules covalently modified by LC3/GABARAP are membrane phosphol

247 P) analogues in which the gamma-phosphate is covalently modified by two different biodegradable maski

248 o approach), in which the gamma-phosphate is covalently modified by two different biodegradable maski

249 Substrates can be covalently modified by ubiquitin chains of different top

250 dditional evidence suggested that benzamides covalently modified Cys239 within the colchicine binding

251 at the interface between 1-phenyloctane and covalently modified highly-oriented pyrolytic graphite (

252 We also identify and characterize a covalently modified variant that arises through reactivi

253 Wnt is a secreted glycoprotein covalently modified with a cis-unsaturated fatty acyl gr

254 ence of hepatocyte-derived exosomal proteins covalently modified with amoxicillin, flucloxacillin, an

255 ed localised surface plasmons (cLSPs) and is covalently modified with an aptamer specific for bisphen

256 MLKL inhibitor Necrosulfonamide, which also covalently modifies Cys86, must employ a different mode

257 ells through aquaporin membrane proteins and covalently modifies cytoplasmic proteins to regulate sig

258 At nanomolar concentration, disulfiram covalently modifies human/mouse Cys191/Cys192 in GSDMD t

259 pathway in animal development and cancer: it covalently modifies the Sonic hedgehog (SHH) ligand, res

260 We now report that (1) S-nitrosothiols covalently modify both NBT and TNBT, but only change the

261 ic acid targets, while enzymatic suppressors covalently modify Cas ribonucleoprotein complexes or deg

262 pha-chloroacetamide (alphaCA) compounds that covalently modify cysteine-54 (C54) of the MPC2 subunit

263 Compound 4 did not covalently modify other closely related PRMTs, potently

264 dins (IsoLGs) and malondialdehyde (MDA) that covalently modify proteins.

265 opment of a small molecule-based approach to covalently modify recombinant and endogenous bromodomain

266 inhibits HlyU from binding to target DNA by covalently modifying Cys30.

267 Ps inactivate acetylcholinesterase (AChE) by covalently modifying its catalytic serine.

268 ce [bipy-Ru(II) (CO)(2) Cl(2) ] site that is covalently mounted onto a polyphenylene framework.

269 Molecules that can walk covalently on a track have been demonstrated, and we now

270 osphate, DMNP) compared to MOFs that are non-covalently, physically entrapped in nylon, thus highligh

271 ly introducing an electrophilic 'warhead' to covalently react with a nucleophile on the target.

272 y to immune cells has accompanied the use of covalently reactive beta5i inhibitors, whose activity ag

273 ing exosite 2 in the catalytic domain by the covalently retained propiece in meizothrombin.

274 he prefusion SARS-CoV-2 S ectodomain trimer, covalently stabilized by a disulfide bond in the closed

275 S-PAGE further show that trimer 4(F20Cha), a covalently stabilized trimer derived from peptide 3(F20C

276 rt, we describe the design and production of covalently stabilized ZIKV E dimers, which lack precurso

277 urce of megadalton hyaluronan or they can be covalently-stabilized to the surface.

278 the cytoplasmic domain as being critical for covalently stabilizing dimers.

279 rm of the ZIKV E protein that is forced in a covalently stable dimeric conformation (cvD).

280 large, macrocyclic receptor composed of two covalently strapped electron-rich bis-pyrrolidine PDI pa

281 uracil-DNA glycosylase and an alkoxyamine to covalently tag and sequence uracil-containing DNA fragme

282 The resulting inhibitors were designed to covalently target a reactive cysteine in the binding sit

283 jic acid analogues as TEAD inhibitors, which covalently target the cysteine in the central pocket, bl

284 rt a simple, scalable, bench-top approach to covalently tethered nylon-MOF polymer composite material

285 ssical drugs have spurred the development of covalently tethered photoswitchable ligands to control n

286 Here, we demonstrate that covalently tethered small molecule fragments can be used

287 ific trimethyl-locked quinone trigger moiety covalently tethered to a phenoxy-dioxetane moiety throug

288 -based Voltage Reporters (RhoVR) that can be covalently tethered to genetically encoded, self-labelin

289 st and an aminocyclopropenium cocatalyst are covalently tethered.

290 ural attributes, we further demonstrate that covalently tethering a supramolecular polymer built from

291 s rely on a chloroacetamide moiety to modify covalently the protein's catalytic selenocysteine residu

292 eport anticancer molecule RA190, which binds covalently to hRpn13 and UCHL5, to require hRpn13 Pru an

293 Moreover, we show that CDDO-Im binds covalently to Keap1 by forming permanent Michael adducts

294 While In is bonded covalently to neighboring Te, Ag binds ionically.

295 hed to SWCNT (Single-walled carbon nanotube) covalently to obtain three dimensional porous hybrid mat

296 with the mutant cysteine residue by binding covalently to the switch-II pocket (S-IIP) that is prese

297 n contrast to CDDO-Me), as low as 50 nM, can covalently transacylate arginine and serine residues in

298 e specificities of RNA-modifying enzymes and covalently trap RNAs with engineered proteins.

299 X-ray structures of mutant enzymes with covalently trapped ceftazidime suggested that a change o

300 Phenolic compounds are known to bind non-covalently with starch, but the impact of this interacti