ライフサイエンスコーパス: cramp

1 cathelicidin-related antimicrobial peptide (CRAMP).

2 riod was significantly prolonged in writer's cramp.

3 ia (PD), cervical dystonia (CD) and writer's cramp.

4 mice genetically defective in production of CRAMP.

5 epsis by LzMPC treatment required endogenous CRAMP.

6 ent the penetration of the inner membrane by CRAMP.

7 of FPRL1/mouse formyl peptide receptor-2 by CRAMP.

8 ystonias, including torticollis and writer's cramp.

9 tor tasks that elicited dystonia or writer's cramp.

10 e in the patients with dystonia and writer's cramp.

11 erse and significantly different in writer's cramp.

12 cally inhibit S. aureus killing by synthetic CRAMP.

13 by enhanced expression of beta-defensins and CRAMP.

14 not been previously investigated in writer's cramp.

15 oth the CCR2 ligand CCL2 and an Fpr2 agonist CRAMP.

16 ficient sleep time or nocturnal leg jerks or cramps.

17 tools with fever, prostration, and abdominal cramps.

18 es included increased muscle tone and muscle cramps.

19 irus include diarrhea, vomiting, and stomach cramps.

20 women, is characterized by painful menstrual cramps.

21 res included a history of myalgia and muscle cramps.

22 acterized by exercise intolerance and muscle cramps.

23 ematologic derangements or complained of leg cramps.

24 shed light on contributing factors to muscle cramps.

25 include bloody diarrhea and severe abdominal cramps.

26 villous blunting that leads to diarrhea and cramping.

27 somotor symptoms (0.96 vs 0.85, P<.001), leg cramps (1.10 vs 0.91, P<.001), and bladder control sympt

28 se events were joint pain (15 [38%]), muscle cramp (15 [38%]), and fatigue (12 [31%]) in the 20 mug g

29 had nausea (20 [30%] vs 4 [6%]) and stomach cramps (15 [23%] vs 2 [3%]) more often than those receiv

30 uded alopecia (29%), dysgeusia (29%), muscle cramps (29%), and anorexia (14%).

31 vomiting (25%), fatigue (27.3%), and muscle cramps (4.5%).

32 ms (71%), throat discomfort (63%), or muscle cramps (42%).

33 ted nausea (95%), dizziness (72%), abdominal cramps (58%), headache (52%), vomiting (51%), chills (48

34 ed abdominal symptoms were distension (77%), cramping (73%) and nausea (67%).

35 ns were characterized by diarrhea (100%) and cramps (79%-88%) lasting a median of 3-5 days.

36 Patients reported diarrhea (100%), abdominal cramps (93%), fever (93%), bloody stools (72%), and vomi

37 as the ortholog of human cathelicidin/LL37 (CRAMP), a molecule externalized in the NETs.

38 h staphylocidal activities demonstrated that CRAMP, a cationic antimicrobial peptide, is primarily re

39 luate further the expression and function of CRAMP, a peptide corresponding to the predicted COOH-ter

40 but at the expense of symptoms that include cramping abdominal pain, fecal urgency, and diarrhea.

41 pointed molecule capable of penetrating the cramped active sites of tryptase.

42 lectron microscopy that the primary locus of CRAMP activity appears to be intracytoplasmic, rather th

43 f neutrophils and monocytes, indicating that CRAMP acts as a chemotactic factor in vivo.

44 alized pain, swelling, itchiness, and muscle cramping after accidental envenomation.

45 Muscle cramps, alopecia, weight loss, fatigue, and dysgeusia we

46 CRAMP also induced calcium mobilization and the activati

47 oating and in dizziness, headache and muscle cramps, although the decrease in systemic symptoms was n

48 cytokine production increased that indicated CRAMP amplified the innate immune response later in the

49 to cathelin-related anti-microbial peptide (CRAMP), an anti-microbial peptide expressed at high leve

50 t in cathelin-related antimicrobial peptide (CRAMP; an ortholog of the sole human cathelicidin, LL-37

51 roduction tasks in 15 patients with writer's cramp and 15 matched healthy control subjects.

52 bduction movements in patients with writer's cramp and compared them with those of normal aged-matche

53 e further identified increased expression of Cramp and formation of neutrophil extracellular traps in

54 or control network in patients with writer's cramp and healthy matched controls.

55 amellar body-derived antimicrobial peptides, CRAMP and mBD3, declined after Ox challenges, parallelin

56 gamma) as well as the antimicrobial peptides CRAMP and mbetaD-3.

57 mplicated in the pathophysiology of writer's cramp and other primary dystonias, endogenous dopamine r

58 DTS modulates the expression of TLR and CRAMP and topical application of TLR agonists in EDE mic

59 Cramping and nausea were the most common adverse effects

60 tors were tender, tiring-exhausting, aching, cramping and sickening.

61 The frequency of logging of cramps and acne is lower in older participants, while lo

62 One patient experienced abdominal cramps and diarrhea necessitating interruption of brinci

63 Muscle cramps and hypophosphatemia were more common in the imat

64 may benefit patients with painful spasms or cramps and neck pain; their long-term use for low back p

65 Susceptibility to exertional cramps and rhabdomyolysis in myophosphorylase deficiency

66 of inhibitors that extend from the polar and cramped (and so not easily druggable) substrate-binding

67 ed rotation and multiple-pulse spectroscopy (CRAMPS) and mixture analysis using references (MAR).

68 the antimicrobial peptides beta-defensin 3, CRAMP, and chemokine CXCL10 and its receptor CXCR3 in co

69 and LDC infiltration and induction of IL-22, CRAMP, and mbetaD-3.

70 oms of frequency, nocturnal bowel movements, cramping, and bleeding returned close to baseline values

71 ed AEs, diarrhea, flatulence, abdominal pain/cramping, and constipation were most common.

72 ptoms, including emesis, diarrhea, abdominal cramping, and gastrointestinal bleeding.

73 to peanut experienced lip swelling, stomach cramping, and objective tiredness.

74 hydrocyanic acid cause dizziness, vomiting, cramping, and sleeping disorders.

75 siness, disturbed sleep, muscle soreness and cramping, and trouble remembering things.

76 02 patients screened, 195 (27.8%) had muscle cramps, and 91 (13.0%) met the inclusion criteria.

77 ecological problems, vasomotor symptoms, leg cramps, and bladder control problems, whereas women in t

78 ities included gynecomastia/gynecodynia, leg cramps, and grade 1 or 2 diarrhea.

79 On his return, he developed diarrhea, cramps, and loose stools without blood or mucus in the a

80 , one characterized by exercise intolerance, cramps, and myoglobinuria, and the other dominated by fi

81 elevated CK levels, muscle weakness, muscle cramps, and persistent myalgia and CK elevations after s

82 pickle brine and taurine for reducing muscle cramps, and tadalafil for improving sexual dysfunction i

83 the arm used for drug infusion, ptosis, leg cramps, and visual and voice changes.

84 in at 1 year; fewer headaches, dizziness, or cramps; and shorter postdialysis recovery time.

85 Compared to Apoe(-/-) mice, Cramp(-/-) Apoe(-/-) mice exhibit reduced lesion sizes w

86 rrhosis experience symptoms including muscle cramps (approximately 64% prevalence), pruritus (39%), p

87 Muscle cramps are among the common debilitating complications o

88 cathelicidin-related antimicrobial peptide (CRAMP), are important effectors of the innate immune sys

89 d vice versa, suggesting the use of FPRL1 by CRAMP as a receptor.

90 ed in middle life with incapacitating muscle cramps associated with calf hypertrophy and only mild cl

91 Bark extracts (1%) from Birch, Cramp Bark, Slippery Elm, White Oak, Red Willow, White W

92 e medical records of the assessment of their cramps before and one month after starting the supplemen

93 and cathelin-related antimicrobial peptide (CRAMP), both known inflammatory mediators.

94 Menstrual cycle-associated symptoms (e.g., cramps, breast swelling), digestive, mood, and integumen

95 nts often report that early symptoms include cramps brought on by cold or exertion.

96 Unexpectedly, we found that mature CRAMP, but not Ac2-26, induced ROS production through an

97 ion in patients with arthritis and menstrual cramps, but they have not provided any benefit to patien

98 concentrations of human (LL-37) and murine (CRAMP) cathelicidins, human alpha-defensin (HBD-1, HBD-2

99 e of antimicrobial human (LL-37) and murine (CRAMP [cathelin-related antimicrobial peptide]) cathelic

100 cal (pruritus and dry skin), painful (muscle cramps, chest pain and abdominal pain) or involve sexual

101 Mice deficient in the gene encoding CRAMP (Cnlp(-/-)) demonstrate impaired lung bacterial cl

102 mmatory cytokine and chemokine production in CRAMP-/- compared to C57BL/6 neonates.

103 Additionally, daily, weekly, and monthly cramps completely resolved in 29 (31.9%), 21 (23.1%), an

104 DBS treatment of tardive dystonia, writer's cramp, cranial dystonia, myoclonus dystonia, and off-sta

105 oprotein E-deficient mice, pDC depletion and Cramp-deficiency in bone marrow reduced atherosclerosis

106 Wild-type and CRAMP-deficient animals were exposed to cigarette smoke

107 CRAMP-deficient hosts demonstrated less intense cytokine

108 CRAMP-deficient mice exhibited significantly lower bladd

109 yed early neutrophil influx were observed in CRAMP-deficient mice infected with Pseudomonas aeruginos

110 evident as early as 1 hour after infection, CRAMP-deficient mice showed no baseline alterations in i

111 n was delayed early but increased by 48 h in CRAMP-deficient mice, which was associated with enhanced

112 of lung tumors in wild-type mice, but not in CRAMP-deficient mice.

113 tment of myeloid cell into tumor tissue in a CRAMP-dependent manner.

114 ne marrow chimera experiments indicated that CRAMP derived from bone marrow cells rather than structu

115 dmitted to the hospital because of abdominal cramping, diarrhea, hematochezia, fever to a peak temper

116 l disturbances, breast tenderness, abdominal cramping, dizziness, headache, and mood changes.

117 Whereas Cramp/DNA complexes aggravated atherosclerotic lesion fo

118 be stimulated to produce interferon-alpha by Cramp/DNA complexes, and we further identified increased

119 that the murine mature cathelicidin peptide (CRAMP), encoded by the mouse gene (Camp), is functionall

120 cathelicidin-related antimicrobial peptide (CRAMP, encoded by CRAMP) was downregulated in LGG-treate

121 trigeminal neuralgia, neck pain, and painful cramps; evidence suggested SMRs for fibromyalgia, low ba

122 Additionally, CRAMP exerted bactericidal activity against K. pneumonia

123 Although CRAMP exhibits in vitro antibacterial activity against U

124 tase-polymerase chain reaction also detected CRAMP expression in adult testis, spleen, stomach, and i

125 l ligation and puncture caused a decrease in CRAMP expression in the liver, whereas enteral administr

126 CRAMP expression is induced in the lung in response to i

127 Examples of application to fatigue, cramps, falls, and mental health in chronic liver diseas

128 yokymia, neuromyotonia, Isaacs' syndrome and Cramp-Fasciculation Syndrome to describe the motor manif

129 1 had significantly (P < .05) more abdominal cramps, fatigue, transient hearing loss, febrile neutrop

130 and vaginal itching, low back pain, uterine cramps, fetal distress, and preterm labor.

131 This gene, named Cramp for cathelin-related antimicrobial peptide, was ma

132 Median daily, weekly, and monthly cramp frequency and severity were higher in females (P-v

133 Thus, CRAMP functions as both a chemoattractant for phagocytic

134 Neonatal mice with a deleted CRAMP gene (CRAMP-/-) were intranasally infected with in

135 eas enteral administration of LzMPC restored CRAMP gene expression in these animals.

136 , mBD4 (short interfering RNA knockdown), or CRAMP (genetic knockout) exhibited enhanced disease seve

137 d the PMv-M1 inhibition only in the writer's cramp group.

138 ith confirmed liver cirrhosis who had muscle cramps >= 4 times per month without other secondary etio

139 or 2 adverse events of loss of taste, muscle cramps, hair loss, and weight loss.

140 tary angiopathy, nephropathy, aneurysms, and cramps (HANAC) syndrome.

141 ary angiopathy with nephropathy aneurysm and cramps (HANAC) syndrome.

142 CRAMP has been shown to have both antimicrobial and angi

143 rine cathelin-related antimicrobial peptide (CRAMP) has been reported to inhibit S. Typhimurium growt

144 tients with task-specific dystonia (writer's cramp) have impaired cortical inhibition likely arising

145 n of cathelin-related antimicrobial peptide (CRAMP; human LL-37 orthologue), and mouse beta defensin

146 obility impairment, sensory symptoms, muscle cramps, impaired upper limb function, respiratory impair

147 d for the extracellular release of AnxA1 and CRAMP in a subcutaneous air pouch model.

148 sion of REG3gamma but not beta-defensins and Cramp in IECs.

149 insights emphasize the age-specific role of CRAMP in influenza viral pathogenesis.

150 ive N-terminal peptide Ac2-26, and processed CRAMP in limited fashion.

151 the neutrophil granule protein cathelicidin (CRAMP in mouse, LL37 in human) in atherosclerosis.

152 d infiltrating immune cells, but the role of CRAMP in neonatal defense to respiratory viruses is unkn

153 lapse of symptoms such as abdominal pain and cramping in patients with irritable bowel syndrome.

154 erved except for mild diarrhea and abdominal cramping in the infusion group on the infusion day.

155 ems to be a promising therapeutic option for cramps in liver cirrhosis.

156 frequency, duration, and severity of muscle cramps in patients with liver cirrhosis.

157 city was grade 3/4 diarrhea and/or abdominal cramps in six of 12 patients treated at 24 mg/m(2), desp

158 ic attacks, persistent myokymia with painful cramps in skeletal muscles, and epilepsy.

159 idin cathelin-related antimicrobial peptide (CRAMP) in a murine model of Fusarium solani keratitis.

160 cathelicidin-related antimicrobial peptide (CRAMP) in macrophages and enhanced bactericidal activity

161 h the percentage change of all the mentioned cramp indices (P-values < 0.05), and age correlated with

162 Changes in cramp indices did not differ significantly between males

163 balm is herbal tea used for soothing stomach cramps, indigestion, and nausea.

164 l-derived cathelicidins (human: LL37, mouse: CRAMP) induce adhesion of classical monocytes but not of

165 Furthermore, CRAMP induced the chemotaxis of human embryonic kidney 2

166 CRAMP-induced calcium flux in monocytes was desensitized

167 Injection of CRAMP into mouse air pouches resulted in the recruitment

168 Mouse CRAMP is a key effector protein secreted by infected epi

169 Writer's cramp is a task-specific focal hand dystonia characteriz

170 aken together, our findings demonstrate that CRAMP is an important contributor to effective host muco

171 CRAMP is released from emigrated neutrophils and then tr

172 by permeability barrier requirements and (2) CRAMP is required for permeability barrier homeostasis.

173 Unlike in mouse macrophages, in which CRAMP is upregulated during infection, camp gene express

174 um toxin is clinically effective in writer's cramp, it does not reverse the associated dysfunction of

175 ng dialysis, refractory symptoms (eg, muscle cramps, itching), and malfunction of dialysis access can

176 ccinia pox formation occurred in four of six CRAMP knockout animals and in only one of 15 control mic

177 CRAMP knockout mice and control animals were inoculated

178 ne cells as an important source of increased CRAMP levels as the infection progressed and CRAMP produ

179 However, whether CRAMP, like human cathelicidin/LL-37, also exhibits a di

180 We have observed that CRAMP, like LL-37, was chemotactic for human monocytes,

181 The patient complained of cramp-like abdominal pain and nausea.

182 ased expression of the antimicrobial peptide Cramp/LL37 in atherosclerotic lesions may thus stimulate

183 traps complexed to the antimicrobial peptide Cramp/LL37 in autoimmune disease.

184 gnificant decrease in flatulence, intestinal cramps, loose stools and diarrhea.

185 Our results demonstrate CRAMPS-MAR as an alternative quantification technique th

186 l API species as model systems, we show that CRAMPS-MAR can provide a lower quantitation limit than s

187 CRAMPS-MAR can provide high (1)H spectral resolution wit

188 Furthermore, CRAMPS-MAR was found to be robust for cases that are ina

189 method for rapid API quantification, termed CRAMPS-MAR.

190 ECR and FCR co-contraction in writer's cramp may be a compensatory process under voluntary cont

191 xel-based results also suggest that writer's cramp may be associated with reduced striatal dopamine r

192 findings suggest that patients with writer's cramp may have divergent responses in striatal dopamine

193 BD-3 production ex vivo and was required for CRAMP, mBD-3, and mBD-14 expression in response to S. au

194 to Fpr2(-/-) mice, in the inflamed airway of CRAMP(-/-) mice, DC trafficking into the peribronchiolar

195 espite an apparent increase in mBD3 protein, CRAMP-/- mice delayed permeability barrier recovery, att

196 AAF the bulky AAF moiety would reside on the cramped minor groove side of the template.

197 igated whether the cathelicidin-related AMP (CRAMP) modulated the development of experimental autoimm

198 CRAMP mRNA and protein were localized to the salivary gl

199 EDE decreased CRAMP mRNA and protein.

200 and cathelin-related antimicrobial peptide (CRAMP) (murine homologues of hBD2 and LL-37, respectivel

201 in gain of function, manifesting with muscle cramping, myalgias, and rod formation in F5.

202 patients with dystonia (n = 6) and writer's cramp (n = 5).

203 erse events attributed to X-82 including leg cramps (n = 2), elevated alanine aminotransferase (n = 2

204 weight loss of 20% or more (n=6) and muscle cramps (n=2).

205 CRAMP-/- neonates had improved survival over C57BL/6 neo

206 ed rotation and multiple pulse spectroscopy (CRAMPS) NMR spin exchange measurements in combination wi

207 in type or underlying mechanism (eg, painful cramps, nociceptive pain, or neuropathic pain).

208 zol--elevated liver-enzyme levels and muscle cramps--of grade 2 or less occurred in 41% and 33% of th

209 d 62%, respectively) without causing pain or cramping or increasing serum creatine kinase.

210 r extremity DVT, such as swelling (71%) or a cramping or pulling discomfort in the thigh or calf (53%

211 back pain, fibromyalgia, headaches, painful cramps or spasticity, and other syndromes.

212 Common side effects were diarrhea, cramping, or bloating (11/31, 35%).

213 scle, causing exercise intolerance, myalgia, cramps, or fixed weakness, which often affects extraocul

214 ercentage change in the monthly frequency of cramps (P-value = 0.042).

215 e intestinal problems (P = 0.009 for pain or cramps; P = 0.02 for excessive gas).

216 patients with fever and abdominal symptoms (cramping, pain, distention, diarrhea, GI bleeding), shou

217 most common side effect was lower abdominal cramping/pain (P = .01).

218 reased serum creatinine level, insomnia, leg cramps, paresthesias, and tremor, were managed with dose

219 Ac2-26 and CRAMP peptides enhanced the release of CXCL2 by CG/NE ne

220 The mature human (LL-37) and mouse (CRAMP) peptides are encoded by similar genes (CAMP and C

221 Many symptoms, such as muscle cramps, poor-quality sleep, pruritus, and sexual dysfunc

222 ians; repetitive tasks, prolonged or awkward/cramped positions, and bending/twisting were contributor

223 the same task repeatedly, working in awkward/cramped positions, working in the same position for long

224 myeloid cells showed impaired recruitment of CRAMP-positive cells into the lung.

225 A Streptococcus revealed that both LL-37 and CRAMP potently inhibited bacterial growth.

226 This study shows that CRAMP produced by different cell types has opposing effe

227 CRAMP levels as the infection progressed and CRAMP production drove mortality.

228 C57BL/6 neonatal mice increased CRAMP production significantly, in direct contrast to th

229 He also experienced progressive muscle cramps, profound sweating, bowel disturbances (diarrhoea

230 ccommodated in the shallow and comparatively cramped recognition pocket; it has fewer hydrogen bondin

231 eletal muscle, causing exercise intolerance, cramps, recurrent myoglobinuria, or fixed weakness, whic

232 Thus, CRAMP represents the first antibiotic peptide found in c

233 The human and mouse cathelicidins (LL-37 and CRAMP, respectively) are expressed at select epithelial

234 Antiserum against CRAMP revealed abundant expression in myeloid precursors

235 As in ITD, our patients with writer's cramp showed impaired activation of the contralateral pr

236 nd unaffected hand in patients with writer's cramp showed significantly less reduction in 20- to 30-H

237 e side chains and that confined movements of cramped side chains within and through the tunnel fine-t

238 lking instability, depression or anxiety and cramps/spasms) three months in advance.

239 In atherosclerotic aortas, we could detect CRAMP specifically in neutrophils, but not in monocytes

240 NET-associated CRAMP stimulated IL-6 production by dendritic cells via

241 n (CPE) is responsible for the diarrheal and cramping symptoms of human C. perfringens type A food po

242 movement model to distinguish normal versus cramped-synchronized (CS) GMs using cosine similarity an

243 by manifestations including fever, abdominal cramps, tenesmus, and malaise.

244 later disease stage, neurons also expressed CRAMP that reduced EAE severity.

245 eutrophil extracellular traps (NETs) rich in CRAMP that were required for EAE initiation.

246 acterized by sensory paresthesias and muscle cramps that are notably exacerbated by cooling.

247 of increasingly severe neuropathic pain and cramps that have been poorly responsive to a variety of

248 Cathelin-related antimicrobial peptide (CRAMP), the orthologue of human cathelicidin/LL-37, is t

249 daily, weekly, and monthly frequency of the cramps, their severity, and their mean duration followin

250 ic GI symptoms (eg, gas, diarrhea, abdominal cramping), there were no significant differences between

251 pocket pain (five [4%]), and muscle spasm or cramp (three [2%]).

252 nal outcomes included length of bleeding and cramping, time to expulsion, and experience of adverse e

253 enty-five patients (89%) experienced pain or cramps/tired muscles, whereas 3 (11%) remained symptom-f

254 Functional studies showed CRAMP to be a potent antibiotic against Gram-negative ba

255 lly, simultaneous administration of OVA with CRAMP to mice promoted both humoral and cellular Ag-spec

256 both Mig-14 and VirK inhibit the binding of CRAMP to Salmonella, and demonstrate that Mig-14 is an i

257 cathelicidin-related antimicrobial peptide (CRAMP), to innate mucosal immunity in a mouse model of G

258 account for covariates (e.g. injury, stomach cramps, training intensity).

259 atients with torticollis, nine with writer's cramp, two with blepharospasm and 16 healthy control sub

260 in symptoms (bloody diarrhea, abdominal pain/cramps, urgency, rectal bleeding, fatigue/tiredness) was

261 abolite, stimulated the expression of neural CRAMP via the free fatty acids receptors 2/3 (FFAR2/3),

262 ns, the anti-microbial activity of LL-37 and CRAMP was determined against the common wound pathogen g

263 By use of intravital microscopy, CRAMP was found to be deposited by activated neutrophils

264 The murine cathelicidin (CRAMP) was detected in the adult by reverse-transcriptio

265 ted antimicrobial peptide (CRAMP, encoded by CRAMP) was downregulated in LGG-treated neonates.

266 ed rotation and multiple pulse spectroscopy (CRAMPS), water adsorption, and nitrogen measurements rev

267 ractice, whereas many patients with writer's cramp (WC) have a history of average hand use.

268 ors reported more musculoskeletal stiffness, cramps, weakness and joint swelling (P < .001), cataract

269 oss-correlograms from patients with writer's cramp were either flat or modulated by a 11-12-Hz tremor

270 these antimicrobial peptides, and LL-37 and CRAMP were rapidly cleaved by released amebic cysteine p

271 ithout other secondary etiologies for muscle cramps were evaluated for inclusion.

272 Grade 0, 1, 2, and 3 abdominal cramps were observed in 32%, 45%, 21%, and 2% of patient

273 of diarrhea, nausea, vomiting, and abdominal cramps, were recorded.

274 Neonatal mice with a deleted CRAMP gene (CRAMP-/-) were intranasally infected with influenza viru

275 n the fine motor control network in writer's cramp, which could be artificially restored to its norma

276 ases, except the mouse antimicrobial peptide CRAMP, which we speculate works in part by inhibiting cy

277 control subjects and patients with writer's cramp while they write a stereotyped word repetitively a

278 or a mouse macrophage antimicrobial peptide (CRAMP), while SodCI remained tethered within the peripla

279 r acute effects included diarrhea and muscle cramping, while with repeated dosing, anorexia and fatig

280 CD spectral analysis showed that CRAMP will form an amphipathic alpha-helix similar to ot

281 logy of two idiopathic focal dystonias: hand cramp with excessive cocontractions of agonist and antag

282 rds, and included queries about diarrhea and cramps, with 2.6% of users querying respiratory symptoms