ライフサイエンスコーパス: crave

1 th 21 days of abstinence (ie, 'incubation of craving').

2 nt increases in food craving ('incubation of craving').

3 n after 1 day (incubation of methamphetamine craving).

4 han after 1 d (incubation of methamphetamine craving).

5 asure smoking cues vs. neutral cues elicited craving).

6 he motivational craving state (incubation of craving).

7 from the drug (incubation of methamphetamine craving).

8 ses during abstinence (incubation of cocaine craving).

9 ive allosteric modulator delay incubation of craving.

10 ment of drug seeking, and incubation of drug craving.

11 ng abstinence and is associated with reduced craving.

12 mbles in this new form of incubation of drug craving.

13 ereafter mediate the expression of incubated craving.

14 s (NAc), a critical brain region for cocaine craving.

15 ffects were observed for tobacco and cocaine craving.

16 ure to drug-associated cues that induce drug craving.

17 tive effects) in human laboratory studies of craving.

18 , and, in cocaine-dependent persons, cocaine craving.

19 n animals show incubation of methamphetamine craving.

20 ) on momentary ratings of cocaine and heroin craving.

21 re, as well as reductions in tonic levels of craving.

22 strated time course of incubation of cocaine craving.

23 AMPARs contributes to incubation of cocaine craving.

24 ergo a comparable magnitude of incubation of craving.

25 espite adverse consequences and intense drug craving.

26 pioids in the neural systems underlying drug craving.

27 rios to investigate the neural correlates of craving.

28 s demonstrated incubation of methamphetamine craving.

29 detect incubation of subjective cue-induced craving.

30 ty accompanies incubation of methamphetamine craving.

31 tic intervention in the treatment of cocaine craving.

32 nsembles that mediate incubation of nicotine craving.

33 om these synapses and thereby reduce cocaine craving.

34 ereafter mediate the expression of incubated craving.

35 ted the development of incubation of cocaine craving.

36 g effects and marginally with alleviation of craving.

37 ant given the habitual nature of cue-induced craving.

38 -dependent incubation of cue-induced cocaine craving.

39 nomena of the "sweet tooth" and carbohydrate craving.

40 itofrontal cortex connectivity and levels of craving.

41 DNA demethylation, in incubation of cocaine craving.

42 responses were correlated with self-reported craving.

43 early abstinence is associated with greater craving.

44 both nicotine reinforcement and cue-elicited craving.

45 he incubation of methamphetamine and cocaine craving.

46 inence and is thought to underlie cue-evoked craving.

47 nt expression or inhibition of incubation of craving.

48 bstinence would prevent incubation of heroin craving.

49 nence prevents incubation of methamphetamine craving.

50 availability, which was associated with less craving.

51 of abuse, a phenomenon termed incubation of craving.

52 Using incubation of cue-induced cocaine craving, a rat relapse model depicting progressive inten

53 nimal model of incubation of methamphetamine craving after choice-based voluntary abstinence in male

54 a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence.

55 In female rats, incubation of craving after either intermittent or continuous drug acc

56 eveloped a rat model of incubation of opioid craving after electric barrier-induced voluntary abstine

57 In contrast, incubation of craving after forced abstinence was associated with acti

58 f-administration showed incubation of heroin craving after forced but not voluntary abstinence.

59 r, AZD8529, on incubation of methamphetamine craving after forced or voluntary abstinence.

60 an animal model to study incubation of drug craving after prolonged voluntary abstinence, mimicking

61 ceptors in the incubation of methamphetamine craving after voluntary abstinence and that DMS neuronal

62 ults show that incubation of methamphetamine craving after voluntary abstinence generalizes to female

63 ritical to the incubation of methamphetamine craving after voluntary abstinence.

64 Indeed, individuals addicted to alcohol also crave alcoholic beverages and spend time and put much ef

65 t is currently unknown whether incubation of craving also occurs after adolescent-onset nicotine self

66 Our results suggest that incubation of food craving alters brain reward circuitry and macronutrient

67 e-induced relapse than subjective reports of craving, although this hypothesis must be empirically te

68 One study reported that cue-elicited craving among detoxified heroin addicts was substantiall

69 (50 mg/day) in reducing alcohol drinking and craving among FHP drinkers with beneficial effects that

70 for 3 consecutive days) on drug cue-induced craving and anxiety in drug-abstinent individuals with h

71 trast to placebo, significantly reduced both craving and anxiety induced by the presentation of salie

72 CBD's potential to reduce cue-induced craving and anxiety provides a strong basis for further

73 rrelated with the number of drinks consumed, craving and anxiety scores.

74 ting phytocannabinoid, to reduce cue-induced craving and anxiety, two critical features of addiction

75 Activation in the amygdala correlated with craving and arousal ratings of alcohol stimuli; correlat

76 They establish that incubation of craving and associated CP-AMPAR plasticity occur much mo

77 R-E training could attenuate smoking-related craving and behavior.

78 compared between groups and correlated with craving and BMI change.

79 s ability to suppress stress-induced alcohol craving and brain responses in treatment seeking alcohol

80 nectivity and individual differences in food craving and changes in body mass index (BMI).

81 e sensitive to food cues, reporting stronger craving and consuming larger portions after food cue exp

82 In contrast, craving and CP-AMPAR levels remain high on WD60.

83 oup showed significant decrease in cigarette craving and craving-related P300 amplitudes compared wit

84 Cigarette craving and craving-related P300 were assessed at pre-ne

85 The craving and deficits in executive function in the so-cal

86 and can reduce drug-induced motor behaviors, craving and dependence.

87 the NAc in the incubation of methamphetamine craving and describe adaptations in synaptic transmissio

88 t is not implicated in incubation of cocaine craving and does not undergo CP-AMPAR plasticity.

89 ngthened the associations between subjective craving and dorsal striatum and precuneus connectivity w

90 e neurobiological processes that incite drug craving and drive relapse has the potential to help targ

91 tural rewards while increasing reactivity to craving and drug cues.

92 ments associated with prior drug use provoke craving and drug taking, and set the stage for lapse/rel

93 drugs of abuse, such as ethanol, can trigger craving and drug-seeking behavior.

94 e frontal gyrus and inferior frontal gyrus), craving and interoceptive processing (anterior insula),

95 self-administration and incubation of heroin craving and introduces a fully automatic social self-adm

96 and associated secondary outcomes of alcohol craving and mood, anxiety, and sleep disturbances, which

97 asures of cue- and stress-induced changes in craving and mood.

98 m and related clinical manifestations (i.e., craving and persistence of unhealthy habits).

99 tations such as alcohol withdrawal syndrome, craving and physical dependence, as well as extrahepatic

100 Primary outcomes were cue-elicited craving and physiological responding to familiar and nov

101 orrelated negatively with ratings of cocaine craving and positively with how high subjects felt durin

102 ories of the effects of the drug, leading to craving and potential relapse.

103 weakened the associations between subjective craving and precuneus functional connectivity with senso

104 l striatum connectivity correlated with food craving and predicted BMI gains.

105 textual drug-associated memories precipitate craving and relapse in cocaine users.

106 vides a model of persistent vulnerability to craving and relapse in human addicts.

107 hat closely resembles stressors that promote craving and relapse in humans.

108 synaptic homeostasis that might limit opioid craving and relapse vulnerability.

109 pharmacological intervention that may reduce craving and relapse with minimal side effects in alcohol

110 opin-releasing factor (CRF) in the IC during craving and relapse, a subsequent experiment found that

111 can be engaged by sleep to regulate cocaine craving and relapse, and demonstrate sleep-based therape

112 taste processing, and is implicated in drug craving and relapse.

113 e to environmental stimuli that trigger drug craving and relapse.

114 strong drug-associated memories that lead to craving and relapse.

115 y of CRF1 blockade in stress-induced alcohol craving and relapse.

116 by triggering drug using memories that drive craving and relapse.

117 ne-seeking behavior, an animal model of drug craving and relapse.

118 seeking can paradoxically potentiate opioid craving and relapse.

119 rug reward can be powerful triggers for drug craving and relapse.

120 ave been shown to reduce measures of cocaine craving and seeking, raising the hypothesis that regulat

121 PSEs or PNEs while cue-induced self-reported craving and smoking behavior were assessed.

122 hort-term and long-term effects on cigarette craving and smoking behaviour, suggesting the neurofeedb

123 states, has recently been implicated in drug craving and social stress.

124 r agonists in decreasing stress-induced drug craving and stress-induced initial heroin lapse.

125 tion by showing that NTX reduced cue-induced craving and subjective responses to MA.

126 naltrexone was defined as the difference in craving and the difference between the number of drinks

127 In addiction, risk factors for craving and use include stress and drug-related cues.

128 of dorsal striatal networks relevant to food craving and weight gain.

129 cuitry may be responsible for increased food craving and weight gain.

130 icipants reported the severity of stress and craving and whether they had seen or been offered opioid

131 ings indicate that smoking-induced relief of craving and withdrawal reflects primarily non-nicotine e

132 metabolizers reported greater reductions of craving and withdrawal than slow metabolizers, with dose

133 included abstinence symptoms (withdrawal and craving) and cognitive test responding (N-back; continuo

134 ding duration and severity of alcohol abuse, craving, and anxiety or depressive symptoms) were signif

135 n associated with later stages of addiction, craving, and cue-induced relapse.

136 ns over a 90-day follow-up period and fNIRS, craving, and HAM-D assessments.

137 including promoting abstinence, diminishing craving, and reducing risk of relapse.

138 at may contribute to continued opioid abuse, craving, and relapse.

139 drawal-associated negative affective states, craving, and relapse.

140 s were average drinks/day and mood, anxiety, craving, and sleep quality ratings.

141 thesis tested SL/SDL phenotype, pretreatment craving, and their interaction as moderators of frequenc

142 comes and for associated symptoms of alcohol craving, anxiety, and mood symptoms.

143 In human addicts, drug relapse and craving are often provoked by stress.

144 derlying this 'incubation of methamphetamine craving' are unknown.

145 elevated after incubation of methamphetamine craving, as recently found for cocaine.

146 Craving, assessed with the Alcohol Urge Questionnaire an

147 sulin significantly reduced morning nicotine craving (b=3.65, P0.05).

148 Twenty IGD subjects participated in a group craving behavioral intervention (CBI) and were scanned b

149 0.05), sedation (beta = 2.38, p < 0.05), and craving (beta = 3.28, p < 0.001) in the laboratory, and

150 robiological similarities and differences in craving between these disorders.

151 er withdrawal (incubation of methamphetamine craving), but the underlying mechanisms are largely unkn

152 of the main causes of alcohol relapse is the craving caused by environmental cues that are associated

153 The neurofeedback effects on craving change and smoking amount at the 4-month follow-

154 low (n = 40) craving for alcohol, with high craving defined as greater than the median.

155 fter prolonged withdrawal, incubated cocaine craving depends on strengthening of nucleus accumbens (N

156 o control levels was associated with reduced craving ("desire and intention to drink" and "negative r

157 re to and dependence on nicotine, as well as craving during abstinence from smoking, without signific

158 Understanding the trajectory of cue-induced craving during abstinence in humans is of importance for

159 altrexone was associated with higher alcohol craving during the ADP (F(1,81) = 4.88, p = 0.030).

160 n alcohol-induced stimulation, sedation, and craving during the alcohol administration (k = 51 studie

161 ions that reduced stimulation, sedation, and craving during the alcohol administration were associate

162 PF-5190457 (100 mg b.i.d.) reduced alcohol craving during the cue-reactivity procedure.

163 pellets would elicit a greater incubation of craving effect than those paired with standard chow (SC)

164 xperience a significant blunted cue-elicited craving effect.

165 phine appears to produce beneficial HDL- and craving effects and, contrary to methadone, its role in

166 llets and were then tested for incubation of craving either 1 or 30 days after training.

167 xacerfont treatment had no effect on alcohol craving, emotional responses, or anxiety.

168 sure to drug-associated cues, provoking drug craving even after prolonged abstinence.

169 oal of our second study was to replicate the craving findings from the original trial and expand this

170 The KOR is implicated in drinking and craving following naltrexone therapy in alcohol use diso

171 and cortical regions differentiated between craving food and craving social interaction.

172 SL) phenotype interacts with a high level of craving for alcohol and is associated with an improved r

173 s and Relevance: The SL phenotype and a high craving for alcohol independently and particularly in co

174 The SL/SDL phenotype and a high craving for alcohol merit further investigation as facto

175 y pretreatment high (n = 40) or low (n = 40) craving for alcohol, with high craving defined as greate

176 Rats showed robust incubation of craving for both food rewards, although responding for c

177 Finally, incubation of craving for chow and high fat was accompanied by an incr

178 unlike in human laboratory studies to date, craving for cocaine and heroin is greater with the combi

179 cipants also completed subjective ratings of craving for cocaine before presentation of a cue, and ra

180 Objective: To assess cue-induced craving for cocaine in humans using both subjective and

181 Craving for cocaine progressively increases in cocaine u

182 onic feelings toward cocaine) and "wanting" (craving for cocaine) after presentation of cocaine-relat

183 hat brain stimulation has an acute effect on craving for drugs and alcohol, but few studies have inve

184 Whether there is an increase in craving for high-fat (HF) food over time, which may cont

185 Craving for methamphetamine was negatively associated wi

186 s exclusively, did not display incubation of craving for SC pellets, suggesting that prior history wi

187 Furthermore, they increased craving for sweet foods, increased sleep disturbance, an

188 ated with cumulative methamphetamine use and craving for the drug.

189 fication (incubation) of cue-induced cocaine craving has been demonstrated after withdrawal from this

190 fication (incubation) of cue-induced cocaine craving has been demonstrated after withdrawal from this

191 negative mood, generally, would 1) increase craving, impatience, and actual addictive substance use

192 activation and reduce stress-induced alcohol craving in alcohol-dependent patients.

193 ith EB3, abolished the incubation of cocaine craving in both male and female rats.

194 vented the emergence of incubation of heroin craving in both sexes.

195 ers might be a risk factor for stress-relief craving in cocaine use disorder.

196 seeking in animal models and stress-induced craving in human studies, guanfacine has not been report

197 ocaine and heroin seeking in rats and heroin craving in humans.

198 dministration would potentiate incubation of craving in male and female rats and examined the estrous

199 choice-induced abstinence, and incubation of craving in rats trained in the standard semiautomatic pr

200 Next, we compared incubation of craving in rats with a history of standard (no-screen) o

201 nence prevents incubation of methamphetamine craving in rats.

202 tate, participants were assessed for alcohol craving in response to stressful or alcohol-related cues

203 The incubation of cue-induced drug craving in rodents provides a model of persistent vulner

204 ygdala activity correlated with decreases in craving in the bias modification but not the sham traini

205 life stress was partly decoupled from opioid craving in the clonidine group, supporting the authors'

206 further characterized incubation of nicotine craving in the rat model by determining whether this inc

207 nd was accompanied by enhanced incubation of craving in the same rats.

208 e noted in measures of depression or cocaine craving in this stress-minimized setting.

209 hen investigated DS-controlled incubation of craving, in the absence of drug-paired CSs.

210 Cue-induced methamphetamine craving increases after prolonged forced (experimenter-i

211 ciated with time-dependent increases in food craving ('incubation of craving').

212 anti-craving pathways in regulating cocaine craving-induced relapse.

213 d to demonstrate that incubation of nicotine craving is also observed after adolescent-onset nicotine

214 Incubation of cocaine craving is partially mediated by progressive accumulatio

215 mpared with PNEs, was associated with higher craving levels (F(2,180)=18.32, p<0.0001) and greater ad

216 trast, the subjective assessment of baseline craving (mean [SD] rating: 2 days, 26.05 [9.85]; 1 week,

217 evaluated brain regions was associated with craving measured in both ADPs.

218 Self-reported opioid craving (measured by a visual analog scale; 0-100) was c

219 specific relationship was found between both craving measures and the dorsal, but not in ventral stri

220 0.11-1.02; F1,67 = 5.36; P = .02), and high craving moderated heavy drinking (7.1 fewer heavy drinki

221 r methadone provided self-reports of stress, craving, mood, and behavior on electronic diaries for up

222 Although neither craving nor CP-AMPAR levels were measured in the present

223 ults demonstrate that incubation of nicotine craving occurs after adolescent-onset nicotine self-admi

224 was not influenced by changes in subjective craving or expired carbon monoxide, suggesting that conn

225 rch target with the potential to reduce drug craving or seeking behaviors.

226 s on any other measures of drinking, alcohol craving, or alcohol-related consequences.

227 SC pellets demonstrated equivalent levels of craving over an abstinence period of 30 days.

228 ly improved anxiety, depression, and alcohol craving over the course of the trial.

229 By comparison, smoking cues elicited greater craving over time compared to neutral cues, and Glycine

230 Baseline craving (p < 0.001) and HAM-D assessment (p < 0.01) were

231 number of drinks consumed (p's < 0.001) and craving (p's < 0.001).

232 g circuits in the midbrain as important anti-craving pathways in regulating cocaine craving-induced r

233 Cue-induced drug craving progressively intensifies after withdrawal from

234 king Withdrawal Scale (P = 0.04) and Tobacco Craving Questionnaire (P = 0.014).

235 In the classical incubation of drug craving rat model, drug seeking is assessed after homeca

236 Cocaine craving ratings positively correlated with the strength

237 TX + MEM followed NTX alone (p = 0.009), but craving reduction was maintained when NTX + MEM was foll

238 bles CP-AMPAR accumulation and incubation of craving, reflecting weakening of mGlu1-dependent mechani

239 e of ibudilast on subjective (including drug craving), reinforcing, and analgesic effects of oxycodon

240 ng changes in subsequent measures of cocaine craving/relapse.

241 ignificant decrease in cigarette craving and craving-related P300 amplitudes compared with the yoked-

242 Cigarette craving and craving-related P300 were assessed at pre-neurofeedback

243 ss, but not disgust, increased self-reported craving relative to a neutral state.

244 he relationship between spine plasticity and craving remains unclear.

245 The mean craving response to both familiar and novel smoking cues

246 The craving response to smoking-associated cues in humans or

247 the Alcohol Urge Questionnaire and the Yale Craving Scale, and drinking behavior were recorded in ea

248 pants reported lower levels of craving (Yale Craving Scale: -11 +/- 1, p < .0001; Alcohol Urge Questi

249 aine) compared with the midazolam group, and craving scores were 58.1% lower in the ketamine group th

250 Combining fNIRS results, baseline craving scores, and HAM-D scores created a robust predic

251 tive idea that acute isolation causes social craving, similar to the way fasting causes hunger.

252 rced to be isolated from each other, do they crave social interactions?

253 After isolation, people felt lonely and craved social interaction.

254 ions differentiated between craving food and craving social interaction.

255 Similar patterns were observed for alcohol craving; specifically, a significant reduction in cravin

256 time-dependent increase in the motivational craving state (incubation of craving).

257 Although craving states are important to both cocaine dependence

258 ing period, while controlling withdrawal and craving symptoms.

259 esults indicate a novel mechanism of alcohol craving that involves MMP-9-dependent synaptic plasticit

260 or sensitization and the development of drug craving-that are associated with chronic use of addictiv

261 orced responding, and the incubation of drug craving (the time-dependent increase in drug seeking aft

262 om the drug and tests for incubation of drug craving (the time-dependent increase in drug seeking dur

263 ding the phenomenon of "incubation of heroin craving" (the time-dependent increases in heroin seeking

264 e, we used a rat model of incubation of drug craving, the neuronal activity marker Fos, and the Daun0

265 For cocaine craving, the Stress x Cue interaction term had a positiv

266 astically suppresses drinking, even in water-craving thirsty animals.

267 extinction training substantially attenuated craving to both familiar and novel smoking cues and redu

268 ods), like the smell of brownies, can elicit craving to eat and increase the amount of food consumed.

269 f alcohol-induced stimulation, sedation, and craving track medication effects from the human laborato

270 and methamphetamine, expression of incubated craving ultimately depends on strengthening of nucleus a

271 the dexamethasone-CRF test, but left alcohol craving unaffected.

272 s targeting the neural systems implicated in craving/urge states in addictions.

273 than-additive) effects of stress and cues on craving, using ecological momentary assessment (EMA).

274 on was associated with better HDL and opioid craving values.

275 lapse in drug addiction is the experience of craving via exposure to cues previously associated with

276 During follow-up, craving was assessed using the Desire for Alcohol Questi

277 The combination of the SL phenotype and high craving was associated with a strong response to naltrex

278 Incubation of methamphetamine craving was associated with CP-AMPAR accumulation in NAc

279 Expression of incubated craving was decreased by intra-NAc core 1-naphthyl acety

280 Consequently, incubation of cocaine craving was decreased persistently.

281 Craving was evaluated using two established protocols, o

282 Food craving was indicated with subjective ratings of visual

283 Self-reported opioid craving was initially less with XR-NTX than with BUP-NX

284 sma aldosterone levels, alcohol drinking and craving was investigated in alcohol-dependent patients.

285 ween midbrain D2/D3 BPnd and methamphetamine craving was not detected.

286 Incubation of cocaine craving was observed in both sexes after either intermit

287 ng; specifically, a significant reduction in craving was observed when NTX + MEM followed NTX alone (

288 Heroin craving was significantly reduced under active ibudilast

289 n of drug self-administration (incubation of craving) was lower after social choice-induced abstinenc

290 id self-administration (incubation of opioid craving) was stronger after voluntary abstinence than af

291 Depressive symptoms and drug craving were also correlated with opioid use in MMPs.

292 Subjective effects of oxycodone and drug craving were measured with visual analog scales (VAS) an

293 ape deformations associated with cue-induced craving were specific to striatal subregions involved in

294 cting the interoceptive awareness of tobacco craving with a larger brain network that motivates smoki

295 iagnostic group interaction in self-reported craving, with CD participants reporting strong cocaine c

296 On five separate days, craving, withdrawal, affect, and sustained attention wer

297 All cigarettes equally alleviated craving, withdrawal, and negative affect in the whole sa

298 We also found no significant improvements in craving, withdrawal, or cognitive function.

299 es of depression and self-report measures of craving would also be associated with opioid use.

300 Participants reported lower levels of craving (Yale Craving Scale: -11 +/- 1, p < .0001; Alcoh