ライフサイエンスコーパス: craving

1 th 21 days of abstinence (ie, 'incubation of craving').

2 nt increases in food craving ('incubation of craving').

3 n after 1 day (incubation of methamphetamine craving).

4 han after 1 d (incubation of methamphetamine craving).

5 he motivational craving state (incubation of craving).

6 asure smoking cues vs. neutral cues elicited craving).

7 ses during abstinence (incubation of cocaine craving).

8 ive allosteric modulator delay incubation of craving.

9 ment of drug seeking, and incubation of drug craving.

10 mbles in this new form of incubation of drug craving.

11 ng abstinence and is associated with reduced craving.

12 ereafter mediate the expression of incubated craving.

13 s (NAc), a critical brain region for cocaine craving.

14 ffects were observed for tobacco and cocaine craving.

15 ure to drug-associated cues that induce drug craving.

16 tive effects) in human laboratory studies of craving.

17 , and, in cocaine-dependent persons, cocaine craving.

18 n animals show incubation of methamphetamine craving.

19 ) on momentary ratings of cocaine and heroin craving.

20 re, as well as reductions in tonic levels of craving.

21 strated time course of incubation of cocaine craving.

22 AMPARs contributes to incubation of cocaine craving.

23 ergo a comparable magnitude of incubation of craving.

24 espite adverse consequences and intense drug craving.

25 pioids in the neural systems underlying drug craving.

26 rios to investigate the neural correlates of craving.

27 s demonstrated incubation of methamphetamine craving.

28 detect incubation of subjective cue-induced craving.

29 ty accompanies incubation of methamphetamine craving.

30 tic intervention in the treatment of cocaine craving.

31 nsembles that mediate incubation of nicotine craving.

32 om these synapses and thereby reduce cocaine craving.

33 ereafter mediate the expression of incubated craving.

34 ted the development of incubation of cocaine craving.

35 g effects and marginally with alleviation of craving.

36 ant given the habitual nature of cue-induced craving.

37 -dependent incubation of cue-induced cocaine craving.

38 nomena of the "sweet tooth" and carbohydrate craving.

39 responses were correlated with self-reported craving.

40 early abstinence is associated with greater craving.

41 both nicotine reinforcement and cue-elicited craving.

42 he incubation of methamphetamine and cocaine craving.

43 inence and is thought to underlie cue-evoked craving.

44 bstinence would prevent incubation of heroin craving.

45 nt expression or inhibition of incubation of craving.

46 nence prevents incubation of methamphetamine craving.

47 availability, which was associated with less craving.

48 of abuse, a phenomenon termed incubation of craving.

49 involved in the mechanisms underlying opioid cravings.

50 Using incubation of cue-induced cocaine craving, a rat relapse model depicting progressive inten

51 nimal model of incubation of methamphetamine craving after choice-based voluntary abstinence in male

52 a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence.

53 In female rats, incubation of craving after either intermittent or continuous drug acc

54 eveloped a rat model of incubation of opioid craving after electric barrier-induced voluntary abstine

55 In contrast, incubation of craving after forced abstinence was associated with acti

56 f-administration showed incubation of heroin craving after forced but not voluntary abstinence.

57 r, AZD8529, on incubation of methamphetamine craving after forced or voluntary abstinence.

58 an animal model to study incubation of drug craving after prolonged voluntary abstinence, mimicking

59 ceptors in the incubation of methamphetamine craving after voluntary abstinence and that DMS neuronal

60 ults show that incubation of methamphetamine craving after voluntary abstinence generalizes to female

61 ritical to the incubation of methamphetamine craving after voluntary abstinence.

62 t is currently unknown whether incubation of craving also occurs after adolescent-onset nicotine self

63 Our results suggest that incubation of food craving alters brain reward circuitry and macronutrient

64 e-induced relapse than subjective reports of craving, although this hypothesis must be empirically te

65 One study reported that cue-elicited craving among detoxified heroin addicts was substantiall

66 (50 mg/day) in reducing alcohol drinking and craving among FHP drinkers with beneficial effects that

67 for 3 consecutive days) on drug cue-induced craving and anxiety in drug-abstinent individuals with h

68 trast to placebo, significantly reduced both craving and anxiety induced by the presentation of salie

69 CBD's potential to reduce cue-induced craving and anxiety provides a strong basis for further

70 rrelated with the number of drinks consumed, craving and anxiety scores.

71 ting phytocannabinoid, to reduce cue-induced craving and anxiety, two critical features of addiction

72 They establish that incubation of craving and associated CP-AMPAR plasticity occur much mo

73 R-E training could attenuate smoking-related craving and behavior.

74 compared between groups and correlated with craving and BMI change.

75 nectivity and individual differences in food craving and changes in body mass index (BMI).

76 e sensitive to food cues, reporting stronger craving and consuming larger portions after food cue exp

77 In contrast, craving and CP-AMPAR levels remain high on WD60.

78 oup showed significant decrease in cigarette craving and craving-related P300 amplitudes compared wit

79 Cigarette craving and craving-related P300 were assessed at pre-ne

80 The craving and deficits in executive function in the so-cal

81 and can reduce drug-induced motor behaviors, craving and dependence.

82 the NAc in the incubation of methamphetamine craving and describe adaptations in synaptic transmissio

83 t is not implicated in incubation of cocaine craving and does not undergo CP-AMPAR plasticity.

84 ngthened the associations between subjective craving and dorsal striatum and precuneus connectivity w

85 e neurobiological processes that incite drug craving and drive relapse has the potential to help targ

86 tural rewards while increasing reactivity to craving and drug cues.

87 ments associated with prior drug use provoke craving and drug taking, and set the stage for lapse/rel

88 drugs of abuse, such as ethanol, can trigger craving and drug-seeking behavior.

89 e frontal gyrus and inferior frontal gyrus), craving and interoceptive processing (anterior insula),

90 self-administration and incubation of heroin craving and introduces a fully automatic social self-adm

91 and associated secondary outcomes of alcohol craving and mood, anxiety, and sleep disturbances, which

92 asures of cue- and stress-induced changes in craving and mood.

93 m and related clinical manifestations (i.e., craving and persistence of unhealthy habits).

94 tations such as alcohol withdrawal syndrome, craving and physical dependence, as well as extrahepatic

95 Primary outcomes were cue-elicited craving and physiological responding to familiar and nov

96 orrelated negatively with ratings of cocaine craving and positively with how high subjects felt durin

97 ories of the effects of the drug, leading to craving and potential relapse.

98 weakened the associations between subjective craving and precuneus functional connectivity with senso

99 l striatum connectivity correlated with food craving and predicted BMI gains.

100 textual drug-associated memories precipitate craving and relapse in cocaine users.

101 vides a model of persistent vulnerability to craving and relapse in human addicts.

102 hat closely resembles stressors that promote craving and relapse in humans.

103 synaptic homeostasis that might limit opioid craving and relapse vulnerability.

104 pharmacological intervention that may reduce craving and relapse with minimal side effects in alcohol

105 opin-releasing factor (CRF) in the IC during craving and relapse, a subsequent experiment found that

106 taste processing, and is implicated in drug craving and relapse.

107 e to environmental stimuli that trigger drug craving and relapse.

108 strong drug-associated memories that lead to craving and relapse.

109 y of CRF1 blockade in stress-induced alcohol craving and relapse.

110 by triggering drug using memories that drive craving and relapse.

111 ne-seeking behavior, an animal model of drug craving and relapse.

112 seeking can paradoxically potentiate opioid craving and relapse.

113 rug reward can be powerful triggers for drug craving and relapse.

114 ave been shown to reduce measures of cocaine craving and seeking, raising the hypothesis that regulat

115 PSEs or PNEs while cue-induced self-reported craving and smoking behavior were assessed.

116 hort-term and long-term effects on cigarette craving and smoking behaviour, suggesting the neurofeedb

117 r agonists in decreasing stress-induced drug craving and stress-induced initial heroin lapse.

118 tion by showing that NTX reduced cue-induced craving and subjective responses to MA.

119 naltrexone was defined as the difference in craving and the difference between the number of drinks

120 In addiction, risk factors for craving and use include stress and drug-related cues.

121 of dorsal striatal networks relevant to food craving and weight gain.

122 cuitry may be responsible for increased food craving and weight gain.

123 icipants reported the severity of stress and craving and whether they had seen or been offered opioid

124 ings indicate that smoking-induced relief of craving and withdrawal reflects primarily non-nicotine e

125 metabolizers reported greater reductions of craving and withdrawal than slow metabolizers, with dose

126 studies have shown that heightened nicotine cravings and blunted response to stress are independent

127 differences in the neural correlates of drug cravings and gambling urges in CD and PG.

128 program that is tailored to counteract food cravings and metabolic changes throughout the menstrual

129 cked' by drug addiction, causing cue-induced cravings and relapse.

130 included abstinence symptoms (withdrawal and craving) and cognitive test responding (N-back; continuo

131 ding duration and severity of alcohol abuse, craving, and anxiety or depressive symptoms) were signif

132 n associated with later stages of addiction, craving, and cue-induced relapse.

133 ns over a 90-day follow-up period and fNIRS, craving, and HAM-D assessments.

134 including promoting abstinence, diminishing craving, and reducing risk of relapse.

135 drawal-associated negative affective states, craving, and relapse.

136 at may contribute to continued opioid abuse, craving, and relapse.

137 s were average drinks/day and mood, anxiety, craving, and sleep quality ratings.

138 thesis tested SL/SDL phenotype, pretreatment craving, and their interaction as moderators of frequenc

139 ms (ie, irritability, sadness, anxiety, food cravings, and bloating) on dutasteride compared with pla

140 comes and for associated symptoms of alcohol craving, anxiety, and mood symptoms.

141 In human addicts, drug relapse and craving are often provoked by stress.

142 elevated after incubation of methamphetamine craving, as recently found for cocaine.

143 Craving, assessed with the Alcohol Urge Questionnaire an

144 sulin significantly reduced morning nicotine craving (b=3.65, P0.05).

145 Twenty IGD subjects participated in a group craving behavioral intervention (CBI) and were scanned b

146 0.05), sedation (beta = 2.38, p < 0.05), and craving (beta = 3.28, p < 0.001) in the laboratory, and

147 robiological similarities and differences in craving between these disorders.

148 er withdrawal (incubation of methamphetamine craving), but the underlying mechanisms are largely unkn

149 of the main causes of alcohol relapse is the craving caused by environmental cues that are associated

150 The neurofeedback effects on craving change and smoking amount at the 4-month follow-

151 or response to cigarette cravings when those cravings conflict with a goal to remain abstinent.

152 low (n = 40) craving for alcohol, with high craving defined as greater than the median.

153 fter prolonged withdrawal, incubated cocaine craving depends on strengthening of nucleus accumbens (N

154 o control levels was associated with reduced craving ("desire and intention to drink" and "negative r

155 duced relief of withdrawal symptoms and drug cravings, despite acting on the same opioid receptors tr

156 re to and dependence on nicotine, as well as craving during abstinence from smoking, without signific

157 Understanding the trajectory of cue-induced craving during abstinence in humans is of importance for

158 altrexone was associated with higher alcohol craving during the ADP (F(1,81) = 4.88, p = 0.030).

159 n alcohol-induced stimulation, sedation, and craving during the alcohol administration (k = 51 studie

160 ions that reduced stimulation, sedation, and craving during the alcohol administration were associate

161 PF-5190457 (100 mg b.i.d.) reduced alcohol craving during the cue-reactivity procedure.

162 pellets would elicit a greater incubation of craving effect than those paired with standard chow (SC)

163 xperience a significant blunted cue-elicited craving effect.

164 phine appears to produce beneficial HDL- and craving effects and, contrary to methadone, its role in

165 llets and were then tested for incubation of craving either 1 or 30 days after training.

166 xacerfont treatment had no effect on alcohol craving, emotional responses, or anxiety.

167 sure to drug-associated cues, provoking drug craving even after prolonged abstinence.

168 oal of our second study was to replicate the craving findings from the original trial and expand this

169 The KOR is implicated in drinking and craving following naltrexone therapy in alcohol use diso

170 and cortical regions differentiated between craving food and craving social interaction.

171 SL) phenotype interacts with a high level of craving for alcohol and is associated with an improved r

172 s and Relevance: The SL phenotype and a high craving for alcohol independently and particularly in co

173 The SL/SDL phenotype and a high craving for alcohol merit further investigation as facto

174 y pretreatment high (n = 40) or low (n = 40) craving for alcohol, with high craving defined as greate

175 Rats showed robust incubation of craving for both food rewards, although responding for c

176 Finally, incubation of craving for chow and high fat was accompanied by an incr

177 unlike in human laboratory studies to date, craving for cocaine and heroin is greater with the combi

178 cipants also completed subjective ratings of craving for cocaine before presentation of a cue, and ra

179 Objective: To assess cue-induced craving for cocaine in humans using both subjective and

180 Craving for cocaine progressively increases in cocaine u

181 onic feelings toward cocaine) and "wanting" (craving for cocaine) after presentation of cocaine-relat

182 hat brain stimulation has an acute effect on craving for drugs and alcohol, but few studies have inve

183 Whether there is an increase in craving for high-fat (HF) food over time, which may cont

184 s exclusively, did not display incubation of craving for SC pellets, suggesting that prior history wi

185 Furthermore, they increased craving for sweet foods, increased sleep disturbance, an

186 ated with cumulative methamphetamine use and craving for the drug.

187 e, initiating high selectivity and prolonged cravings for drug through reward learning.

188 However, males reported a rise in cravings for energy-dense and savory foods not consisten

189 igher levels of disinhibition (P = 0.07) and cravings for savory foods (P = 0.03) compared with the g

190 fication (incubation) of cue-induced cocaine craving has been demonstrated after withdrawal from this

191 fication (incubation) of cue-induced cocaine craving has been demonstrated after withdrawal from this

192 negative mood, generally, would 1) increase craving, impatience, and actual addictive substance use

193 activation and reduce stress-induced alcohol craving in alcohol-dependent patients.

194 ith EB3, abolished the incubation of cocaine craving in both male and female rats.

195 vented the emergence of incubation of heroin craving in both sexes.

196 ers might be a risk factor for stress-relief craving in cocaine use disorder.

197 seeking in animal models and stress-induced craving in human studies, guanfacine has not been report

198 ocaine and heroin seeking in rats and heroin craving in humans.

199 dministration would potentiate incubation of craving in male and female rats and examined the estrous

200 choice-induced abstinence, and incubation of craving in rats trained in the standard semiautomatic pr

201 Next, we compared incubation of craving in rats with a history of standard (no-screen) o

202 nence prevents incubation of methamphetamine craving in rats.

203 tate, participants were assessed for alcohol craving in response to stressful or alcohol-related cues

204 The incubation of cue-induced drug craving in rodents provides a model of persistent vulner

205 further characterized incubation of nicotine craving in the rat model by determining whether this inc

206 nd was accompanied by enhanced incubation of craving in the same rats.

207 e noted in measures of depression or cocaine craving in this stress-minimized setting.

208 HRV being better able to downregulate their cravings in the face of taste temptations.

209 hen investigated DS-controlled incubation of craving, in the absence of drug-paired CSs.

210 ciated with time-dependent increases in food craving ('incubation of craving').

211 anti-craving pathways in regulating cocaine craving-induced relapse.

212 d to demonstrate that incubation of nicotine craving is also observed after adolescent-onset nicotine

213 Incubation of cocaine craving is partially mediated by progressive accumulatio

214 mpared with PNEs, was associated with higher craving levels (F(2,180)=18.32, p<0.0001) and greater ad

215 trast, the subjective assessment of baseline craving (mean [SD] rating: 2 days, 26.05 [9.85]; 1 week,

216 evaluated brain regions was associated with craving measured in both ADPs.

217 Self-reported opioid craving (measured by a visual analog scale; 0-100) was c

218 specific relationship was found between both craving measures and the dorsal, but not in ventral stri

219 0.11-1.02; F1,67 = 5.36; P = .02), and high craving moderated heavy drinking (7.1 fewer heavy drinki

220 r methadone provided self-reports of stress, craving, mood, and behavior on electronic diaries for up

221 Although neither craving nor CP-AMPAR levels were measured in the present

222 ults demonstrate that incubation of nicotine craving occurs after adolescent-onset nicotine self-admi

223 was not influenced by changes in subjective craving or expired carbon monoxide, suggesting that conn

224 rch target with the potential to reduce drug craving or seeking behaviors.

225 s on any other measures of drinking, alcohol craving, or alcohol-related consequences.

226 SC pellets demonstrated equivalent levels of craving over an abstinence period of 30 days.

227 ly improved anxiety, depression, and alcohol craving over the course of the trial.

228 By comparison, smoking cues elicited greater craving over time compared to neutral cues, and Glycine

229 d study, intranasal insulin reduced nicotine cravings over time (b=0.065, P0.05) and the effect laste

230 Baseline craving (p < 0.001) and HAM-D assessment (p < 0.01) were

231 number of drinks consumed (p's < 0.001) and craving (p's < 0.001).

232 g circuits in the midbrain as important anti-craving pathways in regulating cocaine craving-induced r

233 Cue-induced drug craving progressively intensifies after withdrawal from

234 king Withdrawal Scale (P = 0.04) and Tobacco Craving Questionnaire (P = 0.014).

235 In the classical incubation of drug craving rat model, drug seeking is assessed after homeca

236 TX + MEM followed NTX alone (p = 0.009), but craving reduction was maintained when NTX + MEM was foll

237 bles CP-AMPAR accumulation and incubation of craving, reflecting weakening of mGlu1-dependent mechani

238 e of ibudilast on subjective (including drug craving), reinforcing, and analgesic effects of oxycodon

239 ng changes in subsequent measures of cocaine craving/relapse.

240 ignificant decrease in cigarette craving and craving-related P300 amplitudes compared with the yoked-

241 Cigarette craving and craving-related P300 were assessed at pre-neurofeedback

242 ss, but not disgust, increased self-reported craving relative to a neutral state.

243 he relationship between spine plasticity and craving remains unclear.

244 The mean craving response to both familiar and novel smoking cues

245 The craving response to smoking-associated cues in humans or

246 the Alcohol Urge Questionnaire and the Yale Craving Scale, and drinking behavior were recorded in ea

247 pants reported lower levels of craving (Yale Craving Scale: -11 +/- 1, p < .0001; Alcohol Urge Questi

248 aine) compared with the midazolam group, and craving scores were 58.1% lower in the ketamine group th

249 Combining fNIRS results, baseline craving scores, and HAM-D scores created a robust predic

250 tive idea that acute isolation causes social craving, similar to the way fasting causes hunger.

251 ions differentiated between craving food and craving social interaction.

252 Similar patterns were observed for alcohol craving; specifically, a significant reduction in cravin

253 time-dependent increase in the motivational craving state (incubation of craving).

254 Although craving states are important to both cocaine dependence

255 ing period, while controlling withdrawal and craving symptoms.

256 esults indicate a novel mechanism of alcohol craving that involves MMP-9-dependent synaptic plasticit

257 or sensitization and the development of drug craving-that are associated with chronic use of addictiv

258 orced responding, and the incubation of drug craving (the time-dependent increase in drug seeking aft

259 om the drug and tests for incubation of drug craving (the time-dependent increase in drug seeking dur

260 ding the phenomenon of "incubation of heroin craving" (the time-dependent increases in heroin seeking

261 e, we used a rat model of incubation of drug craving, the neuronal activity marker Fos, and the Daun0

262 For cocaine craving, the Stress x Cue interaction term had a positiv

263 extinction training substantially attenuated craving to both familiar and novel smoking cues and redu

264 ods), like the smell of brownies, can elicit craving to eat and increase the amount of food consumed.

265 ith CD participants reporting strong cocaine cravings to cocaine videos, and PG participants reportin

266 ssociated with abstinence-induced subjective cravings to smoke.

267 f alcohol-induced stimulation, sedation, and craving track medication effects from the human laborato

268 and methamphetamine, expression of incubated craving ultimately depends on strengthening of nucleus a

269 the dexamethasone-CRF test, but left alcohol craving unaffected.

270 s targeting the neural systems implicated in craving/urge states in addictions.

271 than-additive) effects of stress and cues on craving, using ecological momentary assessment (EMA).

272 on was associated with better HDL and opioid craving values.

273 lapse in drug addiction is the experience of craving via exposure to cues previously associated with

274 During follow-up, craving was assessed using the Desire for Alcohol Questi

275 The combination of the SL phenotype and high craving was associated with a strong response to naltrex

276 Incubation of methamphetamine craving was associated with CP-AMPAR accumulation in NAc

277 Expression of incubated craving was decreased by intra-NAc core 1-naphthyl acety

278 Consequently, incubation of cocaine craving was decreased persistently.

279 Craving was evaluated using two established protocols, o

280 Food craving was indicated with subjective ratings of visual

281 Self-reported opioid craving was initially less with XR-NTX than with BUP-NX

282 sma aldosterone levels, alcohol drinking and craving was investigated in alcohol-dependent patients.

283 ween midbrain D2/D3 BPnd and methamphetamine craving was not detected.

284 Incubation of cocaine craving was observed in both sexes after either intermit

285 ng; specifically, a significant reduction in craving was observed when NTX + MEM followed NTX alone (

286 Heroin craving was significantly reduced under active ibudilast

287 n of drug self-administration (incubation of craving) was lower after social choice-induced abstinenc

288 id self-administration (incubation of opioid craving) was stronger after voluntary abstinence than af

289 Depressive symptoms and drug craving were also correlated with opioid use in MMPs.

290 Subjective effects of oxycodone and drug craving were measured with visual analog scales (VAS) an

291 ape deformations associated with cue-induced craving were specific to striatal subregions involved in

292 ity to inhibit a motor response to cigarette cravings when those cravings conflict with a goal to rem

293 ne addiction is to reduce relapse-associated cravings, which are typically induced by environmental s

294 cting the interoceptive awareness of tobacco craving with a larger brain network that motivates smoki

295 iagnostic group interaction in self-reported craving, with CD participants reporting strong cocaine c

296 On five separate days, craving, withdrawal, affect, and sustained attention wer

297 All cigarettes equally alleviated craving, withdrawal, and negative affect in the whole sa

298 We also found no significant improvements in craving, withdrawal, or cognitive function.

299 es of depression and self-report measures of craving would also be associated with opioid use.

300 Participants reported lower levels of craving (Yale Craving Scale: -11 +/- 1, p < .0001; Alcoh