ライフサイエンスコーパス: crest

1 heir ability to reprogram trunk into cardiac crest.

2 c landscape to define the presumptive neural crest.

3 e development of melanocytes from the neural crest.

4 s in the developing optic cup require neural crest.

5 eurons, which arise from placodes and neural crest.

6 haracterized by precise cutting on elongated crests.

7 The CREST-2 Registry (C2R) was approved by National Institut

8 flap was placed within 3 mm of the alveolar crest (286/306 sites) as opposed to 50% when the surgica

9 rgical flap was >3 mm away from the alveolar crest (48/96 sites).

10 Here we report that the neural crest, a migratory stem cell population in vertebrate em

11 Chick cardiac crest ablation results in failure of this septation, phe

12 with the ability to rescue PTA after cardiac crest ablation.

13 suppressor screen for restoration of neural crest after leflunomide treatment.

14 We developed CREST, an accurate and fast method that identifies the p

15 The neural crest, an embryonic stem-cell population, is a vertebrat

16 Bone marrow was aspirated from the iliac crest and cells were enriched by Ficoll density gradient

17 ot surface and the distance between the bone crest and cemento-enamel junction (CEJ).

18 ccurs as pigment cells arise from the neural crest and depends on mitfa, an ortholog of MITF, a key r

19 etrimental for the development of the neural crest and for hematopoiesis.

20 Ets1, and Sox8, critical for cardiac neural crest and heart development.

21 the elevation of wave runup exceeds the dune crest and induces landward transport of sediment across

22 understanding of the evolution of the neural crest and its contribution to the vertebrate body.

23 ortant role in the homeostasis of the neural crest and its derivatives, which give rise to pigment-sy

24 transcripts and the clearly distinct neural crest and mesenchymal origin of human SCs and fibroblast

25 ble function in early mesoderm versus neural crest and placode development.

26 ion to central neural fates specifies neural crest and placodes, modulated by fibroblast growth facto

27 ged PRDM1 expression inhibits neural, neural crest and sensory progenitor genes, suggesting that its

28 ency markers and the onset of neural, neural crest and sensory progenitor specifier genes.

29 rm is rapidly subdivided into neural, neural crest and sensory progenitors.

30 in the cortical plate (CP), subplate (gyral crest and sulcal bottom), and IZ.

31 from the interaction of the hindbrain neural crest and the neighboring epibranchial placodal tissues,

32 odermal cell populations, such as the neural crest and the neural plate.

33 tion series and compare the distributions of crest and wave heights observed with theoretical predict

34 ted alveolar bone loss (ABL) on the external crests and in the interradicular bone of the first molar

35 g edges) and insectivorous diets (transverse crests and lobes) suggests a varied faunivorous diet app

36 relations, which tends to be higher in gyral crests and lower in sulcal fundi.

37 t often eat leaves, for example, have longer crests and more sloping occlusal surfaces than those tha

38 ine one subtype of neural crest, the cardiac crest, and demonstrate their ability to reprogram trunk

39 meliorate Znf703 effects on mesoderm, neural crest, and placodes.

40 w and hyoid arch skeleton derive from neural crest, and the pectoral fin skeleton from mesoderm, the

41 rn rockhopper, western rockhopper, Fiordland crested, and Snares crested) that apparently persisted t

42 Floods waned rapidly, eroding antidune crests, and re-deposited removed sediments as patches on

43 culature associated with pronounced sagittal crests-and accompanied increases in muscle volume-assist

44 ion on a widespread lizard, the Puerto Rican crested anole (Anolis cristatellus).

45 Most notably, pronounced sagittal crests are negatively correlated with hard-object feedin

46 f vertebrates, derived from embryonic neural crest, are a useful system for elucidating mechanisms of

47 The cardiac neural crest arises in the hindbrain, then migrates to the hear

48 g this question, we used the cephalic neural crest as a model system and looked at the roles of its b

49 r results indicate that the ancestral neural crest at the base of the vertebrate lineage possessed a

50 e trajectory for sedatives and tranquilisers crested at an older age (35 years) than that for the oth

51 Iliac crest-BM was aspirated from long-bone fracture patients

52 e developing eye is also dependent on neural crest, but only specifically around the retinal pigment

53 ose that the emergence of the cranial neural crest, by progressive assembly of an axial-specific regu

54 cally complexity (i.e., the number of cusps, crests), can be explained by the same developmental mode

55 risingly restricted defect in cranial neural crest cell (cNCC) development.

56 eness was diminished in local cranial neural crest cell (CNCC) populations in both mutants, with SHH

57 smission and early vascularization of neural crest cell (NCC)-derived perivascular cells in the brain

58 been an essential tool for exploring neural crest cell fate and migration routes.

59 s affecting genes involved in enteric neural-crest cell fate that exacerbate the widespread genetic s

60 n 24 genes that play roles in enteric neural-crest cell fate, 7 of which were novel, were also common

61 ranscription factor that orchestrates neural crest cell migration and differentiation; this mutation

62 f crucial importance during embryonic neural crest cell migration, proliferation and differentiation.

63 of brain development, beginning with neural crest cell migration.

64 er identify the role of the different neural crest cell populations in distal gut innervation, and co

65 Differential AQP-1 levels affect neural crest cell speed and direction, as well as the length an

66 opmental processes and play a crucial neural crest cell-autonomous role in frontonasal morphogenesis.

67 sal immunity, in mice with homozygous neural crest cell-conditional deletion of EdnrB (EdnrB(NCC-/-))

68 ome 22 (22q) result in meningiomas in neural-crest cell-derived meninges, while variants affecting He

69 rotein levels are both upregulated in neural crest cell-derived mesenchyme surrounding Meckel's carti

70 netic repression of placodal, but not neural crest, cell fate results in pineal hypoplasia in zebrafi

71 Cardiac neural crest cells (cNCCs) are a migratory cell population that

72 f activity is required within cranial neural crest cells (cNCCs) during CF closure.

73 is innervation of the gut by enteric neural crest cells (ENCCs) to establish the enteric nervous sys

74 ential for TFAP2A expression in human neural crest cells (hNCCs).

75 mplex subunit protein, Med23 in mouse neural crest cells (Med23(fx/fx);Wnt1-Cre), results in microgna

76 t is governed by interactions between neural crest cells (NCC) and the extracellular matrix (ECM).

77 t1-Cre, we show that primary cilia of neural crest cells (NCC), precursors of most AS structures, are

78 lpex phenotype is due to apoptosis of neural crest cells (NCCs) and the cranial neuroepithelium.

79 Neural crest cells (NCCs) are migratory, multipotent embryonic

80 we establish that deletion of Chd7 in neural crest cells (NCCs) causes severe conotruncal defects and

81 ing in zebrafish, we demonstrate that neural crest cells (NCCs) respond rapidly to dying cells and ph

82 We mutated KMT2D in neural crest cells (NCCs) to study cellular and molecular funct

83 ing Xenopus, we identified defects in neural crest cells (NCCs) upon emc1 depletion.

84 ing factor Rbfox2 is expressed in the neural crest cells (NCCs), and deletion of Rbfox2 in NCCs leads

85 In birds, sacral neural crest cells (sNCCs) first give rise to an extramural gan

86 from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent o

87 , to investigate how the evolution of neural crest cells affected the vertebrate body plan, we examin

88 ched for enhancer activity in cranial neural crest cells and craniofacial tissues, several regions ha

89 it results in a fate switch, in which neural crest cells are converted into progenitors of the centra

90 Neural crest cells are embryonic progenitors that generate nume

91 During gastrulation, neural crest cells are specified at the neural plate border, as

92 enter the DREZ before the arrival of neural crest cells at the DREZ.

93 ll analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when

94 Individual neural crest cells colonize the ovary, differentiate into neuro

95 test the intriguing possibility that neural crest cells contribute to heart repair, we examined Dani

96 Cardiac neural crest cells contribute to important portions of the card

97 The results suggest that neural crest cells contribute to many cardiovascular structures

98 During vertebrate development, neural crest cells differentiate as a continuous mass of tissue

99 paired recruitment of endocardial and neural crest cells during the early stages of VIC development.

100 We find that migrating lead cranial neural crest cells express AQP-1 mRNA and protein, implicating

101 chemistry that, in del10 homozygotes, neural crest cells fail to infiltrate the developing SV interme

102 oncoding variant, we demonstrate that neural crest cells fail to migrate into the stria vascularis in

103 dance receptors in the same migrating neural crest cells has novel implications for the concept of gu

104 Neural crest cells have different developmental potencies at di

105 cular perturbation of migrating chick neural crest cells in vivo.

106 d that developmental incorporation of neural crest cells into the SV depends on signaling from HGF/ME

107 The choices that neural crest cells make to become sensory, glial, autonomic, or

108 restricted developmental potential of neural crest cells originating in the head.

109 Neural crest cells produce the extracellular matrix protein nid

110 Lineage tracing of cranial neural crest cells revealed that the cleft resulted not from mi

111 cells originate from vagal and sacral neural crest cells that are initially located at the border of

112 sponse, inducing apoptosis in cranial neural crest cells that would result in craniofacial abnormalit

113 ously associated with the decision of neural crest cells to become sympathetic in other systems, sugg

114 ithelial-to-mesenchymal transition of neural crest cells to emigrate from the neural tube, miR-203 di

115 o-induce cranial epithelial cells and neural crest cells within a spherical cell aggregate.

116 dent on the genetic sex of gonadal or neural crest cells, and may be blocked by repressive guidance s

117 Along with neural crest cells, cranial placodes are considered ectodermal

118 l-autonomous requirement for Med23 in neural crest cells, potentially linking the global transcriptio

119 es in neuroblastoma cells compared to neural crest cells, the presumptive precursors cells for neurob

120 o confer cardiac potential onto trunk neural crest cells, thus implicating new genes in cardiovascula

121 When interrogated in cranial neural crest cells, we identified discrete functions for signal

122 ral plate border and specification of neural crest cells.

123 ll types such as cranial placodes and neural crest cells.

124 ion and maintained in migrating chick neural crest cells.

125 tablish axial-specific populations of neural crest cells.

126 ween the two phenotypes, possibly via neural crest cells.

127 vertebrate embryogenesis, the cranial neural crest (CNC) forms at the neural plate border and subsequ

128 Here we report that a sulphur-crested cockatoo (Cacatua galerita eleonora) responds to

129 collect observations of wing-tagged sulphur-crested cockatoos in central Sydney and record their soc

130 stems such as those observed in wild sulphur-crested cockatoos.

131 ory immunoglobulinA production in the neural crest-conditional deletion of endothelin receptor B mode

132 , we uncover a previously undescribed neural crest contribution to cardiomyocytes of the ventricles i

133 ACs, were administered to chicken and double-crested cormorant (DCCO) embryonic hepatocytes to determ

134 and liver metabolome profiles of the double-crested cormorant (Phalacrocorax auritus), a large (1.5

135 pression in embryonic liver tissue of double-crested cormorants (Phalacrocorax auritus) collected fro

136 In simulated data, CREST correctly classifies 91.5%-100% of grandparent-gra

137 After correcting these, CREST correctly determines relationship types for 93.5%

138 ssion of numerous genes essential for neural crest/craniofacial development.

139 g a pre-existing pattern, the cranial neural crest creates their own migratory pathway by interacting

140 from Paf complex deficiency, rescuing neural crest defects in ctr9 morphant and paf1(aln(z24)) mutant

141 , new developmental processes such as neural crest delamination, and new tissue organizations such as

142 ession pattern with key regulators of neural crest delamination, Phf12 and Snail2, and interacts with

143 tor or morpholinos promotes premature neural crest delamination.

144 network that influences the timing of neural crest delamination.

145 tive enhancer in HAND2-AS1 (heart and neural crest derivatives expressed 2 antisense RNA1, a noncodin

146 d in the down-regulation of heart and neural crest derivatives expressed 2, Kruppel-like factor 15, a

147 tro, suggesting that ADAR1 safeguards neural crest derivatives from aberrant MDA5-mediated interferon

148 s mysterious due to the complexity of neural crest derivatives.

149 for regulating the development of two neural crest derivatives: melanocytes and Schwann cells.

150 zebrafish, TH has opposite effects on neural crest derived pigment cells of the adult stripe pattern,

151 derived), but not neighboring cardiac neural crest-derived (CNC-derived), VSMCs showed impaired Smad2

152 essed selectively in isolated enteric neural crest-derived cells (ENCDC), which also express the dopa

153 del of aganglionosis in which enteric neural crest-derived cells (ENCDCs) express diphtheria toxin (D

154 eurons (Phox2b-Cre; p75(fx/fx)) or in neural crest-derived cells (P0-Cre; p75(fx/fx)) and examined ge

155 the PAAs, and (3) differentiation of neural crest-derived cells adjacent to the PAA endothelium into

156 These cranial neural crest-derived cells migrate to populate a mesodermal mic

157 Cranial neural crest-derived cells provide important regulatory cues to

158 e adrenal chromaffin cells arise from neural crest-derived cells that express Schwann cell markers.

159 dual transcriptomes from thousands of neural crest-derived cells, reconstructed developmental traject

160 RK1/2) signaling in neuroblastoma and neural crest-derived cells.

161 s proliferate and are joined by a few neural crest-derived cells.

162 ons of cranial placode versus cranial neural crest-derived CNgV cells.

163 r role in hyaluronan synthesis in the neural crest-derived craniofacial mesenchyme during palatogenes

164 or the bud initiation stage, when the neural crest-derived ectomesenchyme predominates in the salivar

165 glia in the ENS further suggests that neural crest-derived enteric glia might have evolved after the

166 r invades the interior of the testis, neural crest-derived innervation invades the interior of the ov

167 eostasis in the neural crest, several neural crest-derived lineages and myelinating glia.

168 inactivation of hedgehog signaling in neural crest-derived mandibular mesenchyme led to expansion of

169 hat regulate melanosome transport and neural-crest-derived melanocyte development, respectively.

170 f vertebrate jaws involves patterning neural crest-derived mesenchyme cells into distinct subpopulati

171 han shRNAs for Pten repression in rat neural crest-derived PC-12 cells, and enhanced neurite outgrowt

172 and notch3 lost mesoderm- as well as neural crest-derived pdgfrb (high) MCs.

173 ding decrease in iridophores, another neural crest-derived pigment cell type in zebrafish.

174 Melanocytes are the neural crest-derived pigment-producing cells of the skin that p

175 tional ablation of Nf1 and Arf in the neural crest-derived SC lineage allows escape from senescence,

176 onic enteric neurons arise from trunk neural crest-derived Schwann cell precursors that migrate from

177 om re-specification of cells from the neural crest-derived sox9a(+)/sox10(+) skeletal lineage.

178 irely within mesoderm-derived tissue, neural crest-derived tissue, or at the boundary of the two.

179 CPAMD8 expression was highest in neural crest-derived tissues of the adult anterior segment, sug

180 onal epithelium, cementum with alveolar bone crest destruction, but animals pretreated with Losartan

181 ike genes), involved in cognition and neural crest development (domestic-like genes), or associated w

182 erbivorous mammals showing variable sagittal crest development across species, are ideal models for e

183 d the molecular circuits that control neural crest development along the anteroposterior axis of a ja

184 pe of ADAR1 function to the fields of neural crest development and disease.

185 tion elongation of genes required for neural crest development and melanoma growth in vivo(1).

186 or inhibition of BMP signaling during neural crest development disrupts normal pigment cell developme

187 er, their cell-autonomous function in neural crest development has not been explored.

188 functions in a bimodal manner during neural crest development to regulate specification at the neura

189 orthologs during early embryonic and neural crest development, but have not identified direct regula

190 hildren that arises from anomalies in neural crest development.

191 developmental role in the context of neural crest development.

192 r factor TFAP2A at discrete stages of neural crest development.

193 ed two distinct functions of Hmga1 in neural crest development.

194 l DNA against oxidative damage during neural crest differentiation.

195 eminiscent of Waardenburg syndrome, a neural crest disorder, Myo10(tm2/tm2) mice exhibited pigmentati

196 extant members: bilophodonty (bi: two, loph: crest, dont: tooth), or the presence of two cross-lophs

197 ongly suppressed leflunomide-mediated neural crest effects in zebrafish.

198 rcuit that is specific to the cranial neural crest emerged via the gradual addition of network compon

199 e manifests where Hmga1 loss reduces cranial crest emigration from the dorsal neural tube independent

200 Furthermore, CREST exploits the profound differences in sex-specific

201 t inappropriate p53 activation in the neural crest, facial ectoderm, anterior heart field, and endoth

202 truncus arteriosus (PTA), which trunk neural crest fails to rescue.

203 pes; (3) key neural functions such as neural crest formation are predicted to enhance adaptive immuni

204 disease cells that was enriched for a neural crest G(0)-like state that preexisted in the primary tum

205 acid phenethyl ester (CAPE) disrupts neural crest gene expression, migration, and melanocytic differ

206 of SRCAP nuclear localization, alter neural crest gene programs in human in vitro models and Xenopus

207 The neural crest gives rise to numerous cell types, dysfunction of

208 ince its discovery 150 years ago, the neural crest has intrigued investigators owing to its remarkabl

209 MHC)-based mate preference in the endangered crested ibis (Nipponia nippon) and quantified the impact

210 odern and historic population samples of the crested ibis (Nipponia nippon), an endangered bird that

211 We tested the hypothesis that crested ibis advertise "good genes" through external tra

212 032 sample Generation Scotland (GS) dataset, CREST identified seven pedigrees with incorrect relation

213 rcuit that is specific to the cranial neural crest in amniotes and confers the ability to form cranio

214 Notably, analysis of the cranial neural crest in little skate and zebrafish embryos demonstrated

215 the functional significance of the sagittal crest in tapirs.

216 ttachment area (via the presence of sagittal crests) in carnivorans is correlated with durophagy (i.e

217 control the normal development of the neural crest into cardiomyocytes and reactivation of the neural

218 of negative signals that channel the neural crest into streams.

219 suggests that the initial collective neural crest invasion is based on short-range repulsion and asy

220 tional profile of the lamprey cranial neural crest is more similar to the trunk neural crest of amnio

221 The neural crest is regionalized along the anteroposterior axis, as

222 ic origin of enteric neurons from the neural crest is well established, conflicting evidence exists r

223 ation of the melanocytic lineage from neural crest is well established, its significance in the forma

224 entifier: NCT00190398 (EVA-3S), NCT00004732 (CREST), ISRCTN57874028 (SPACE), and ISRCTN25337470 (ICSS

225 l as with morphogenesis of tissues of neural crest-like origin (melanocytes and neurons, bone and hea

226 d with dental pulp cells, periodontal neural crest lineage differentiation is characterized by repres

227 vation of Has2 throughout the cranial neural crest lineage or specifically in developing palatal or m

228 ivation of Has2 either throughout the neural crest lineage or specifically in the developing palatal

229 order, Hmga1 regulates Pax7-dependent neural crest lineage specification.

230 tion imaging, can extend the scope of neural crest lineage studies beyond development to regeneration

231 Here, we review major discoveries in neural crest lineage tracing from a historical perspective.

232 rom a stem cell population called the neural crest, mechanisms that dictate final neuropil plexus org

233 , which do not arise exclusively from neural crest mesenchyme as previously thought.

234 Melanoblasts deriving from the neural crest migrate along the developing embryo and traverse t

235 topic maintenance of miR-203 inhibits neural crest migration in chick, whereas its functional inhibit

236 uncovered its function in maintaining neural crest migration pattern.

237 lacking, all computational models of neural crest migration published so far have assumed a pre-patt

238 Neural crest migration requires cells to move through an enviro

239 nf703 disrupts patterning of distinct neural crest migratory streams normally delineated by Sox10, Tw

240 een textural properties of food and sagittal crest morphology.

241 yo, melanoblasts originating from the neural crest must traverse the dermis to reach the epidermis of

242 inactivated Pdgfra postnatally in secondary crest myofibroblasts (SCMF), a subpopulation of lung mes

243 but mechanisms coupling Hox genes to neural crest (NC) are unknown.

244 Neural crest (NC) cells are multipotent stem cells that arise f

245 Here, we have used chick neural crest (NC) cells, a highly migratory stem cell populatio

246 rlying development of the multipotent neural crest (NC) embryonic cell population.

247 beta-catenin signaling is crucial for neural crest (NC) formation, yet the effects of the magnitude o

248 The neural crest (NC) is an embryonic cell population that contribu

249 intain multipotent progenitors of the neural crest (NC) lineage in zebrafish.

250 that develops entirely from migratory neural crest (NC) progenitor cells.

251 (LNC) in maintaining the phenotype of neural crest (NC) progenitors to support LEPC.

252 ed in the pre-migratory and migratory neural crest (NC), and has been implicated in the delamination

253 Neuroblastoma (NB), derived from the neural crest (NC), is the most common pediatric extracranial so

254 ateral mesoderm (LM, aortic root) and neural crest (NC, ascending aorta/transverse arch) SMC lineages

255 ssue in a pond-breeding amphibian, the great crested newt Triturus cristatus.

256 al crest is more similar to the trunk neural crest of amniotes.

257 addition of network components to the neural crest of gnathostomes, which subsequently became restric

258 that the cranial subpopulation of the neural crest of the lamprey lacks most components of a transcri

259 undaries of an area of ~0.35 km(2) below the crest of the prehistoric landslide.

260 roperties based on their origins from neural crest or glial cells.

261 Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis.

262 pression of nidogen in the absence of neural crest partially restores optic cup morphogenesis.

263 athetic neurons derived directly from neural crest precursors while adrenal chromaffin cells arise fr

264 and both cell types are derived from neural crest precursors.

265 of nuclear Pax6 (46 kDa) staining and neural crest progenitor status defined by the expression of emb

266 We found that neural crest progenitors display elevated expression of DICER,

267 ardiomyocytes and reactivation of the neural crest program upon regeneration may open potential thera

268 terozygous mutations within TFAP2A, a neural crest regulator for which humans, but not mice, are hapl

269 0+ cells in the apex, sox10 and other neural crest regulatory network genes are upregulated in the re

270 of these structures from mesoderm and neural crest, respectively.

271 molecular mechanisms underlying the cardiac crest's unique potential.

272 ruloids harboring neural progenitors, neural crest, sensory placode and epidermis.

273 ntal processes and homeostasis in the neural crest, several neural crest-derived lineages and myelina

274 ndicate the presence of a small supracranial crest, similar to a sub-adult form of Brachylophosaurus

275 Neural crest specific conditional deletion of Adar1 in mice lea

276 Furthermore, we show that neural crest-specific inactivation of Six1 in Six2 (-/-) embryo

277 Transcriptional profiling identified cardiac-crest-specific transcription factors, with single-cell R

278 dscape of progenitor cells to promote neural crest specification.

279 showed enrichment of mesenchymal and neural crest stem cell signatures similar to human therapy-resi

280 common cellular basis developed from neural crest stem cells.

281 lanation for the formation of cranial neural crest streams in concert with previously reported findin

282 aniofacial cartilage onto non-cranial neural crest subpopulations(3).

283 For MoS(2) transistors fabricated on crested substrates, we observed an almost two orders of

284 ssential for the establishment of the neural crest territory.

285 the dorsal surfaces of the wings, and a red crest that would be consistent with a male of the specie

286 rn rockhopper, Fiordland crested, and Snares crested) that apparently persisted throughout the LGM in

287 on factors that define one subtype of neural crest, the cardiac crest, and demonstrate their ability

288 nt of the endodermal, mesodermal, and neural crest tissues.

289 minant male, female and subordinate juvenile crested tit, respectively.

290 Crested tits (Lophophanes cristatus) and willow tits (Po

291 ions, coinciding with a transition from reef crest to reef slope.

292 rerio adult heart regeneration in the neural crest transgenic line, Tg(-4.9sox10:eGFP).

293 CREST utilizes identity by descent (IBD) segments shared

294 ) predominantly originates from vagal neural crest (VNC) cells that emerge from the caudal hindbrain,

295 from the implant shoulder to the buccal bone crest was 1.6 mm.

296 from the implant shoulder to the buccal bone crest was measured on cross-sectional CBCT images and co

297 s, and the distance between the CEJ and bone crest was significantly greater for teeth with recession

298 Bone volume (BV/TV%) and iliac crest were similar at baseline and at month 4.

299 e surgical flap more closely to the alveolar crest when performing osseous surgery resulted in shallo

300 his subcircuit was sufficient to imbue trunk crest with the ability to rescue PTA after cardiac crest