ライフサイエンスコーパス: crevice

1 t this site would destabilize the R-specific crevice.

2 water-accessible surface of the binding-site crevice.

3 egrees of openness of the corresponding heme crevice.

4 SEA modification occurred within the binding crevice.

5 surface of the water-accessible binding-site crevice.

6 might indicate changes in the catalytic heme crevice.

7 ange in the B chain to expose the A3-related crevice.

8 sani is found at high levels in the gingival crevice.

9 rinse on neutrophil function in the gingival crevice.

10 e acidic residues close to the MTSEA binding crevice.

11 alternative orientations in the binding-site crevice.

12 in between opposing walls of an interdomain crevice.

13 the selectivity filter formed an interdomain crevice.

14 lso extends into the active-site hydrophobic crevice.

15 henicol binds to the exit tunnel hydrophobic crevice.

16 thereby contacts antibiotics bound at either crevice.

17 bulky oxidizing agent to the ligand binding crevice.

18 113), which lies deep within the active site crevice.

19 acids that are exposed to the ligand-binding crevice.

20 ntribute to the surface of this binding-site crevice.

21 ifferentially accessible in the binding-site crevice.

22 ntribute to the surface of this binding-site crevice.

23 , M7) and form a cluster in the binding-site crevice.

24 from the alveolar crest toward the gingival crevice.

25 water-accessible surface of the binding-site crevice.

26 water-accessible surface of the binding-site crevice.

27 the cytoplasmic portion of the binding-site crevice.

28 in fields up to 1 mm closer to the gingival crevice.

29 ntribute to the surface of this binding-site crevice.

30 cysteines are accessible in the binding site crevice.

31 resides in a negatively charged hydrophilic crevice.

32 abolism which can accumulate in the gingival crevice.

33 D2 receptor, is exposed in the binding-site crevice.

34 water-accessible surface of the binding-site crevice.

35 osal-microbial interface in the peri-implant crevice.

36 ffinity CS-binding region within its central crevice.

37 S-pai interactions in the F583-F643 aromatic crevice.

38 and host gene expression in the peri-implant crevice.

39 cupies the entire Y-shaped substrate-binding crevice.

40 bstituent packs within a nonpolar interchain crevice.

41 r mutation Y220C creates a druggable surface crevice.

42 he targeting of an additional subsite in the crevice.

43 cysteines are accessible in the binding-site crevice.

44 myosin linkage yields well-defined molecular crevices.

45 nt of the concept of high-dielectric aqueous crevices.

46 bic plug that separates the water-accessible crevices.

47 water-accessible surface of the binding-site crevices.

48 ater molecules are mainly located in surface crevices.

49 water-accessible surface of the binding-site crevices.

50 ition of silver atoms on the ends and in the crevices.

51 lisecond dynamics of bound waters in protein crevices.

52 annels (1.5 mm x 1.6 mm x 0.1 mm) with small crevices (125 mum x 75 mum and 125 mum x 137 mum).

53 he distal site-a surface-exposed hydrophobic crevice 17 A away from the active site.

54 nstrate that flagella are able to reach into crevices, access additional surface area, and produce a

55 tion allows for the investigation of binding-crevice accessibility at position 278 and suggests that

56 Our data reveal the binding-crevice accessibility of residues T270 (7.35), A273 (7.3

57 The substitution occurs within a crevice adjoining the classical receptor-binding surface

58 spheres, shielded by magnetic fields or rock crevices against harsh cosmic radiation.

59 bly other eNTPDases) contains a water-filled crevice allowing access of water and hydrophilic compoun

60 A set of residues lying along this crevice (amino acids 49, 50, and 53) is suggested to be

61 Finally, we have identified a hydrophobic crevice and a charged region at the tail of each protome

62 an N lobe and a C lobe to clamp RNA-binding crevice and exhibits two protruding extensions in both l

63 P-binding site maps to the side of the dimer crevice and extends to near the dimer interface.

64 4) and Phe(237) in TM5 face the binding-site crevice and form a metal-binding center with His(297) an

65 phyromonas gingivalis colonizes the gingival crevice and is etiologically associated with periodontal

66 ccessible on the surface of the binding-site crevice and is occluded by bound agonist.

67 how these cells live and die in the gingival crevice and periodontal pocket.

68 the Met80 heme ligand swung out of the heme crevice and replaced by a water molecule.

69 water-accessible surface of the binding-site crevice and that 9 of these are occluded by bound antago

70 rial plaque accumulation around the gingival crevice and the subsequent inflammation and destruction

71 ty of bacterial colonization in the gingival crevice and to explore the relationship between shifts i

72 m a directed survey of the human subgingival crevice and to isolate bacteria having rod-like morpholo

73 environment of the tunnel, revealing binding crevices and free-energy barriers for single amino acids

74 Crevices and holes at mm scales on calcareous rock with

75 Finally, surfaces featuring crevices and peaks incorporate between 3.5 and 20 times

76 nctional lifespan of neutrophils in gingival crevices and periodontal pockets and therefore into the

77 mes body weight when traversing the smallest crevices and up to nearly 900 times body weight without

78 immobilized phenyl ligand into a hydrophobic crevice, and that this crevice is closed or tightened wh

79 ounding, development of prominent intercrypt crevices, and absence of apical mucus plugs.

80 The hydrophobic interactions in the binding crevice are much stronger than those observed in cyclode

81 The LMP1 motif is presented in the TRAF3 crevice as a close structural mimic of the PVQET motif i

82 somycin binds to the active-site hydrophobic crevice, as does the aromatic ring of puromycin, while t

83 l zone, which bends the tissue and creates a crevice at the blastopore lip.

84 rred to form the surface of the binding-site crevice based on our application of the substituted-cyst

85 ified regions surround the large hydrophobic crevice based on the NCS-1 crystal structure, this crevi

86 Cysteine is bound in a crevice between adjacent LbetaH domains and underneath a

87 The H+ is released into a water-filled crevice between helices IX and X which becomes transient

88 , EpsH contains at its surface a hydrophobic crevice between its variable and conserved beta-sheets,

89 3 domain loop and CD4 docks to a hydrophobic crevice between MHCII alpha2 and beta2 domains.

90 e-stranded DNA during continued unwinding; a crevice between RecB and RecC increasingly narrows durin

91 second S4 movement opens up an intracellular crevice between S4 and S5 that would allow radial moveme

92 (+) (Kv) channel showed that lipids occupy a crevice between subunits.

93 the role of Val(A3), which projects within a crevice between the A- and B-chains.

94 n their interiors while travelling through a crevice between the boulders.

95 Each binding site is located in a crevice between the C-terminal domains of two subunits w

96 CBR inhibitors target a crevice between the N-terminal portion of the bridge hel

97 e foot-like component and indicates that the crevice between the two lobes comprising the functional

98 e concentration of positive charge along the crevice between the two subdomains suggests that this co

99 ocking studies shows Na(V)beta1 lying in the crevice between the voltage-sensing and pore domains of

100 the N-phenethyl group of fentanyl deep in a crevice between transmembrane (TM) helices II and III wh

101 llular allosteric modulator site formed by a crevice between transmembrane domains 5, 7, and 8, and e

102 to a site located in an extracellular-facing crevice between transmembrane segments S2 and S3 in the

103 three elongated receptors snuggled into long crevices between pairs of monomers of the homotrimeric l

104 tor mechanisms but unexpectedly showed large crevices between subunits within the transmembrane (TM)

105 the (p-aminobenzoyl)glutamate (pABG) binding crevice by approximately 0.5 A.

106 erial diversity within the human subgingival crevice by comparing 264 small subunit rDNA sequences fr

107 t that became accessible in the binding-site crevice by use of methanethiosulfonate ethylammonium (MT

108 omal RNA genes (SSU rDNA) in the subgingival crevice by using quantitative PCR.

109 tors that are accessible in the binding-site crevices by the substituted cysteine accessibility metho

110 as burrowing into sand or sheltering in rock crevices can help minimize hydrodynamic loads, previous

111 e results suggested that compounds bind to a crevice close to the USP14 active site with modest affin

112 Asp17 is positioned in the crevice, close to the substrate thioester C=O, which in

113 re of residues 6.55-6.60 to the binding-site crevice, combined with the divergent amino acid sequence

114 tases and creates a deeper substrate binding crevice, consistent with the ability of InhA to recogniz

115 Both divalent cations bind to ATP within a crevice, contributing to the precise transmission of all

116 chanically driven wear, current fretting and crevice corrosion investigations have yet to precisely r

117 We follow "crevice corrosion" processes in real time in different p

118 material degradation and dissolution (e.g., crevice corrosion) of polycrystalline nonnoble metals, a

119 affected sextant as determined by probeable crevice depth (PD) at initial examination (IE).

120 -like regions at the ends of the interdomain crevice (elastase fold) are used by heparin to bridge th

121 udopilus with EpsH at its tip, the conserved crevice faces away from the helix axis.

122 th K in position 29 when found in saliva and crevice fluid can influence community biofilm compositio

123 ola to grow in a medium that mimics gingival crevice fluid, suggesting that the spirochaete may use s

124 s tunnel to the catalytic triad into a broad crevice for accelerated substrate entry and product exit

125 switch and the opening of the intracellular crevice for G protein coupling.

126 the protein core and a large solvent-exposed crevice for heme binding.

127 s 4 and 3 in the NK(2)R in forming a binding crevice for MTSEA.

128 merization core, generating discrete binding crevices for DNA.

129 tcrop surrounded by tropical forest use rock crevices for refuge and appear dorsoventrally compressed

130 ue for A. laevis may reflect its specialized crevice-foraging hunting technique.

131 tors, is contained within a water-accessible crevice formed among its seven membrane-spanning segment

132 tors, is contained within a water-accessible crevice formed among its seven membrane-spanning segment

133 tors, is contained within a water-accessible crevice formed among its seven membrane-spanning segment

134 tors, is contained within a water-accessible crevice formed among its seven membrane-spanning segment

135 ules, is contained within a water-accessible crevice formed among its seven transmembrane segments (T

136 CRs), is contained within a water-accessible crevice formed among its seven transmembrane segments (T

137 CRs), is contained within a water-accessible crevice formed among its seven transmembrane segments (T

138 g cleft located at the bottom of a 15-A-deep crevice formed between the N- and C-terminal lobes.

139 In the first structure, a positively charged crevice formed by loops 1 and 2 was identified as the si

140 is suggestive of a loose docking within the crevice formed by the open faces of the delta and delta'

141 ed conformation by a direct interaction at a crevice formed by the S4-S5 loop.

142 The mutation (a crevice-forming substitution at a conserved back surface

143 Our results suggest that intersubunit crevices found in the TM domain of the ATP-bound crystal

144 alyx (ECG) in images of the healthy gingival crevice (GC).

145 gs obtained from clinically healthy gingival crevices (GC-w) variably, but significantly, delayed apo

146 ly bond the two PDMS layers and seal off the crevices generated from the thickness of the membranes.

147 a rocky habitat formed of slabs of rock with crevices (grikes) between them where a rich community of

148 stride period only decreased at the smallest crevice height (4 mm), whereas slipping and the probabil

149 istent with Cys 34 being located in a narrow crevice in close proximity to an anionic charge.

150 nds to a previously unidentified hydrophobic crevice in mdm2.

151 the T(6) surface but within an intersubunit crevice in R-containing hexamers.

152 oposed to target a predominantly hydrophobic crevice in the "trimerization domain" of the GLAST monom

153 ng the catalytic Zn(2+) ion and the aromatic crevice in the active site of HDAC6.

154 logue, there is a well-formed AdoHcy-binding crevice in the catalytic domain.

155 surface of the water-accessible binding-site crevice in the dopamine D2 receptor.

156 while the aglycone acceptor binds in a deep crevice in the N-terminal domain.

157 These results suggest a crevice in the p66 thumb subdomain of HIV-1 RT supports

158 es that form the surface of the binding-site crevice in the third and fifth membrane-spanning segment

159 cture possesses a pronounced electropositive crevice in the vicinity of the 3(10) helix, that might p

160 Cockroaches rapidly traversed crevices in 300-800 ms by compressing their body 40-60%.

161 pocket-finding algorithm to identify surface crevices in close proximity to residues determined to be

162 pecimens was surface initiated cracking from crevices in the as-built surface finish.

163 hat the electric field is focused by aqueous crevices in the channel protein.

164 tive at inserting in bilayers, causing water crevices in the hydrocarbon region and placing Cu(2+) ne

165 Gobies compete for crevices in the reef to avoid predation and goby mortali

166 he eyes are reduced in size, have furrows or crevices in the retina, and show a disturbed patterning

167 tion of amino acid residues into hydrophobic crevices in the RNA.

168 ening or closing of the ATP site or of other crevices in the S1 structure.

169 were docked into the PPDK N-terminal domain crevice, in an orientation consistent with substrate/cof

170 efficiently deployed by wedging them in reef crevices, in 1.5 to 7% of the time required for traditio

171 o compete with CD40 for binding to the TRAF3 crevice, influencing downstream signaling to B lymphocyt

172 This crevice is adjacent to the non-overlapping ganglioside-b

173 The crevice is amenable to protein engineering to further en

174 nd into a hydrophobic crevice, and that this crevice is closed or tightened when S1 is in the S1** Mg

175 -bacterial disequilibrium in the subgingival crevice is poorly understood.

176 absent from the A1, A2, and A3 domains, this crevice is shown to correspond to the ristocetin binding

177 ous poxvirus D8 orthologs revealed that this crevice is structurally conserved.

178 anometer proximity or have coalesced to form crevices, is paramount to achieving maximum SERS enhance

179 which forms one wall and the floor of a long crevice leading from the active-site loop.

180 inding site within the Fab formed a distinct crevice lined by a high proportion of apolar amino acids

181 nd is bound by the SH3-like domain in a deep crevice lined by aliphatic amino acid residues and passe

182 ation via a "credit card" mechanism, using a crevice lined with polar residues to shield lipid head g

183 The two beta-sheets pack together to form a crevice, lined with conserved hydrophobic residues: we s

184 icted model, that RNA binds in a deep, basic crevice located entirely within the N-terminal domain.

185 Docking of DHPs inside this crevice located the DHP ring between Phe-1159 of IIIS6 a

186 e located in three symmetrically placed deep crevices located at the interface of two adjacent subuni

187 st adjustments to the main chain of the heme crevice loop and is facilitated by a trimethyllysine 72-

188 utation of Tml72 (yK79H variant) in the heme crevice loop to Ala72 (WT*K79H variant) affects the dyna

189 ed the conformational plasticity of the loop-crevice-loop bioactive sites, a critical property underl

190 Loop-crevice-loop features constitute bioactive sites, where

191 e based on the NCS-1 crystal structure, this crevice may be the association site of KChIPs for the ch

192 movement, it has been suggested that aqueous crevices may penetrate the protein, reducing the extent

193 tors revealed that around the biaryl, a fine crevice might exist in the gp120 binding site.

194 ariants Met102-->Ala and Leu133-->Gly, and a crevice mutant, Phe104-->Ala, were further characterized

195 Positively charged crevices near the active site may explain the enzyme's p

196 -bound protein allows an exposed hydrophobic crevice, near the membrane surface, to serve as a potent

197 High-speed videography revealed crevice negotiation to be a complex, discontinuous maneu

198 Midway between these crevices, nucleotide A2103 of H.marismortui (2062 Escher

199 , one c-di-GMP molecule binds to the central crevice of a STING dimer, using a series of stacking and

200 ically with the lysines surrounding the heme crevice of Cc.

201 cidic residues on opposite sides of the heme crevice of cytochrome c(1) are involved in binding posit

202 The central positively charged crevice of D8 was predicted to be the CS binding site by

203 VACV-304-binding sites along the CS-binding crevice of D8, combined with different efficiencies of b

204 antagonists are anchored in the interdomain crevice of GBR1 by an overlapping set of residues.

205 ic drugs that bind directly to the catalytic crevice of hsEH has been prolonged and sustained over th

206 A crevice of hydrophobic residues linking the polar edge o

207 mobile C-terminal helix inside a hydrophobic crevice of NCS-1 to impede Ric8a interaction.

208 F1-11 can bind to the edge of and within the crevice of the active site of MPO.

209 late group of the subunit into the conserved crevice of the chaperone cleft and the subsequent positi

210 teine becomes accessible in the binding site crevice of the constitutively active beta2 receptor.

211 at the Pi binding site is located within the crevice of the PPDK N-terminal domain, at a site that is

212 insertion of the leader peptide MsrDL into a crevice of the ribosomal exit tunnel, which is conserved

213 g of the nitro-fatty acid to the hydrophobic crevice of the SIRT6 active site exerted a moderate acti

214 ifferentially accessible in the binding-site crevice of these receptors.

215 er loop of kallistatin bound to the reactive crevice of tissue kallikrein indicated that the P2 resid

216 e-repulsion mutation in the receptor-binding crevice of TRAF3 ablated binding of both LTbetaR and NIK

217 linasus) faini ticks collected from the rock crevices of ERB colonies in South Africa and Uganda.

218 f propionic and butyric acid in the gingival crevices of periodontal subjects with severe and mild di

219 aIn "ink" can be assembled by DEP within the crevices of severely damaged wires to create stretchable

220 s blood vessels and axons, especially in the crevices of the brain, where these forces are localized.

221 tly colonized the 3-D surface, localizing to crevices of the EEC model and interacting with multiple

222 t', formed at the junctions and interstitial crevices of the nanostructures and consequently provide

223 n of residues accessible in the binding-site crevices of these receptors by the substituted cysteine

224 uminal domain which binds to a saddle-shaped crevice on a distal tip of BoNT/B.

225 the D2R peptide bind within the hydrophobic crevice on Ca(2+)/NCS-1, but only one copy of the GRK1 p

226 Lys249, Arg307, and Lys311 flanking a small crevice on the p66 thumb subdomain outside the primer-te

227 of the cofactor resides in a solvent-exposed crevice on the protein surface and makes contact with a

228 HveA-Y23 fits into a crevice on the surface of gD and was previously shown to

229 nd HveA-Y23, a residue that protrudes into a crevice on the surface of gD.

230 recognition is mediated in the same binding crevice on the surface of TRAF3.

231 n BAFF-R is accommodated in the same binding crevice on TRAF3 that binds two related TNFRs, CD40 and

232 The PQQAT motif is bound in the same binding crevice on TRAF3 where CD40 is bound, providing a molecu

233 rahydrofuran and acetonitrile molecules into crevices on the enzyme surface and especially into the a

234 he bioactive sites, along with the pores and crevices on the hexamer surface, are prospective targets

235 ic stability of the receptor by wedging into crevices on the hydrophobic surface of A2AR, increasing

236 onnatural side chains that access unoccupied crevices on the receptor surface offers a potential aven

237 f organisms that may recolonize the gingival crevice once antibiotic therapy is complete.

238 Two hydrophobic crevices, one at the peptidyl transferase center and the

239 reserve the structural integrity of the heme crevice: only the nonfunctional His variant allows carbo

240 Thus, the mechanism of heme crevice opening depends upon the position of the ligand

241 T*K79H variant) affects the dynamics of heme crevice opening through a small destabilization of both

242 aking direct contact with the NAD(+)-binding crevice or the donor loop.

243 raphies, where they rapidly became lodged in crevices or cemented to the benthos by encrusting organi

244 P. borchgrevinki by blowing air into subice crevices or pursued them into the platelet ice.

245 Water-filled crevices penetrating into the interior of the membrane-s

246 s which lose their viability within gingival crevices, periodontal pockets and the oral cavity die by

247 s collected from clinically healthy gingival crevices, periodontal pockets, and the oral cavity (sali

248 horter (> or = 40%), consistent with aqueous crevices pervading both the extracellular and intracellu

249 At the end of the crevice, Philae made a 0.25-metre-deep impression in the

250 charged residues located in the RNA-binding crevice play a key role in RNA binding and virus replica

251 ed flow, or how surface topography (grooves, crevices, pores) influence QS-mediated communication.

252 ty in these acceptor substrates binds to the crevice present at the acceptor substrate binding site o

253 These crevices reduce substrate surface area available to the

254 PLIMB-induced modifications to heme crevice sites of trout IV and bovine metHb were determin

255 By varying substrate crevice sizes, we determine the conditions under which h

256 We challenged cockroaches with horizontal crevices smaller than a quarter of their standing body h

257 ic acid (LXA(4)) was applied to the gingival crevice subject to periodontitis.

258 77 binds adjacent to the BH3 peptide-binding crevice, suggesting the possibility of cross-talk betwee

259 eric factors that permit opening of the heme crevice, suggests that higher organisms have evolved to

260 d to dim-light paleoenvironments and/or rock crevices, suggests that V. parvulus lived in a dim-light

261 disulfide bond is deeper in the binding-site crevice than is the N-terminal part of E2.

262 main generates an intimate substrate-binding crevice that allows for recognition and dephosphorylatio

263 p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilize

264 vaginalis ferredoxin (Tvfd) showed a unique crevice that exposed the redox center.

265 ite in doubly-wound alpha/beta folds forms a crevice that is located at the switch point between the

266 rhelical hydrogen bonds and a ligand-binding crevice that is partially covered by a beta-hairpin form

267 almitoylation site and near to an interhelix crevice that is typical of cholesterol binding sites.

268 syntrophic relationships in the subgingival crevice that promote colonization by secondary fermenter

269 ly adaptive "hot spots" in the TRAF3-binding crevice that promote molecular interactions driving spec

270 iative interactions with a number of surface crevices that are generally between secondary structural

271 amer surface is marked by multiple pores and crevices that are potentially accessible to small molecu

272 ly by inducing the formation of water-filled crevices that extend into the interior of the protein.

273 opens up the possibility of probing the deep crevices that occur in microelectronic circuits, and the

274 e-wet purely repulsive surfaces and evacuate crevices, the extent of de-wetting is unclear when ubiqu

275 guish meaningful surfaces from the rocks and crevices they encounter is unknown.

276 avity of the Met102-->Ala mutant into a deep crevice through an additional substitution, but the doub

277 f neutrophils that migrate into the gingival crevice to counteract its harmful effects.

278 ion of how the introduction of submicrometer crevices to a surface affects attachment of Escherichia

279 After traversing horizontal crevices to enter a vertically confined space, cockroach

280 to provide adequate solvation to hydrophobic crevices under the TM1-TM2 hairpin, and clearly reflect

281 The microstructures were fabricated as boxed crevices via a simple and scalable laser ablation techni

282 inhomogeneities (e.g., near-wall regions and crevice volumes) lead to localized cool-flame conditions

283 glycans, whereas in the second structure the crevice was not evident as loops 1 and 2 adopted differe

284 hours in the presence or absence of gingival crevice washings (GC-w) to study the effect of GC-w on n

285 and so may protrude beyond the A3-associated crevice, we investigated analogs containing A3 substitut

286 y interact with residues in the main binding crevice, we show that the 7TM-conserved bridge is essent

287 he most part, the newly created peri-implant crevices were colonized by specific bacteria within 2 we

288 ng Cys-285 to the margin of the binding site crevice where it becomes accessible to MTSEA.

289 cellular portion of M6 into the binding-site crevice where it would be more broadly accessible than t

290 Its ecological niche is the gingival crevice, where the organism adapts to the challenges of

291 Dimerization leads to a large, bowl-shaped crevice, which might be involved in vivo in protecting s

292 e sites of the dimer are connected by a long crevice, which might indicate its potential ability to a

293 f the substrate ligand are bound in a narrow crevice while the nucleotide moiety rests on the protein

294 h-affinity lock-and-key mechanism above this crevice with an unusually large antibody-antigen interfa

295 chains are accommodated within a native-like crevice with minimal distortion.

296 /32 can be attributed to a shallower binding crevice with reduced positive electrostatic charge.

297 nt side chain remains buried in a nativelike crevice with small adjustments in surrounding side chain

298 gating arginines on S4 toward a water-filled crevice within the VSD and allows salt-bridge interactio

299 included only areas adjacent to the gingival crevice, without knowledge or quantitation of alveolar c