ライフサイエンスコーパス: cripple

1 ypes, and virus production was significantly crippled.

2 rbamoyl phosphate and the rest were severely crippled.

3 frequent when the apoptotic mechanisms were crippled.

4 Here, we examined the potential capsule-crippling ability of DFMO and the possible synergistic e

5 t porphyria occasionally causes frequent and crippling acute neurovisceral attacks associated with in

6 contrast, G50A and G50C viruses are severely crippled and form much smaller plaques.

7 Cre recombinase ("on-state"), the intron is crippled and the target gene is disrupted by a series of

8 spread by engaging machinery that ultimately cripples and kills infected cells, yet they are also pos

9 8high natural killer (NK) cells resulting in crippled antibody-dependent cellular cytotoxicity (ADCC)

10 steolysis with carpal and tarsal resorption, crippling arthritic changes, marked osteoporosis, palmar

11 In time, a debilitating, crippling arthritis, hemophilic arthropathy, develops.

12 educe the mortality and morbidity of chronic crippling arthropathy.

13 onstrate that different Jbeta substrates are crippled at different steps of cleavage by distinct comb

14 In addition, mutants of PLC-beta3 with crippled autoinhibition dramatically accelerated the hyd

15 In this study, we crippled autophagy in HSCs by conditionally deleting the

16 lococcus aureus therapy that can effectively cripple bacterial infection, neutralize secretory virule

17 This striking capacity to cripple biofilm assembly mechanisms reveals a new approa

18 ntiating Hag secretion, the mutation of fliS crippled both motility and flagellar filament assembly,

19 Mutations that crippled both the EBS and GC box suppressed both basal a

20 nsp16 interaction was disturbed proved to be crippled but viable.

21 en Cln proteins, we compared CLN2, CLN3, and crippled (but still partially active) CLN2 genes in a ra

22 when the Sln1p/leucine zipper construct was crippled by a mutation of one of the internal leucines,

23 leverage the power of these technologies is crippled by the absence of suitable 'front-end' methods

24 ten structurally preserved, but functionally crippled, by CDKN2A/ARF loss in melanoma, rescue of p53

25 absence of MadA, FliX and FlbD activation is crippled, bypass mutations in FlhA restore flagellar bio

26 pecifically target only ICL1 are unlikely to cripple C. neoformans growth in vivo.

27 how that deletion of the inducible AOX2 gene cripples C. albicans virulence in mice by increasing imm

28 Defects in cytoskeletal proteins can cripple cell strength and may cause cardiomyopathy.

29 LDHA deficiency crippled cellular redox balance and inhibited ATP produc

30 LDHA deficiency cripples cellular redox control and diminishes adenosine

31 s the chromatin binding ability of GATA3 but cripples chromatin reprogramming ability, resulting in f

32 necessary and possibly sufficient to induce crippling chronic skeletal muscle myositis and vasculiti

33 This crippled CI was shown to lack subunits of the "N assembl

34 viral genome disrupted cohesin binding, and crippled colony formation in 293 cells.

35 revealed the presence of a faster migrating crippled complex.

36 rt protein, while the Cys154-->Gly mutant is crippled conformationally.

37 ncreases the dimensionality of the models to crippling degrees, and typically are not validated again

38 scent lifetime measurements circumvented the crippling dimness of an ER-tuned fluorescent redox-respo

39 ng, more individuals are forced to live with crippling disability resulting from the stroke.

40 e leading cause of irreversible blindness, a crippling disability resulting in higher risks of chroni

41 a clear conclusion as to the nature of this crippling disease has yet to be identified.

42 Polioviruses have caused crippling disease in humans for centuries, prior to the

43 A crippling dwarfism was first described in the Miniature

44 boration inequalities that could potentially cripple economic and healthcare systems, escalating to b

45 y one million children each year and imposes crippling economic burdens on families and nations world

46 In this study we show that loss of Id2 cripples effector differentiation and instead programs C

47 ng an alternative M2-like program, which had crippling effects on adaptive antitumor immunity.

48 t it also overcomes memory issues that would cripple existing tools.

49 evoid of gamma134.5 or its amino terminus is crippled for viral growth and release.

50 ion seen in patients: reduced blood flow and crippled functional hyperemia.

51 c lethality interactions with mutations that cripple genes involved in DNA replication and DNA double

52 ical Hodgkin lymphoma (cHL) as derived from "crippled" germinal center B cells that have frequently a

53 Crippled gravitropic response by the transgenic plants i

54 The COVID-19 pandemic has crippled health systems, exacerbated household food inse

55 a species and that perturbation of this site cripples heterochromatic gene silencing.

56 histone H3 mutants enhances silencing at the crippled HMR locus HMRae via restoring Sir binding and t

57 utations that cause increased silencing of a crippled HMR silencer in a rap1 mutant background.

58 NKX2-5 mutants, including those with a crippled homeodomain, bound hundreds of targets includin

59 ) is the causative agent of poliomyelitis, a crippling human disease known since antiquity.

60 ns, and propose that Tat-induced suppression cripples immune surveillance to HIV infection.

61 4A) resulted in an enzyme which was severely crippled in catalysis, in agreement with its position as

62 ly subjected to LPS triggering were severely crippled in IL-12 and TNF-alpha production, a result of

63 uld be reduced artificially but was severely crippled in its ability to be reduced by physiological e

64 CVD 908-htrA in tissue culture and was more crippled in its ability to proliferate after invasion.

65 nds the TRS far less tightly and is severely crippled in its RNA unwinding activity.

66 e of these 2 mutants (and 2 others that were crippled in other RanBP1 functions) retained some abilit

67 boring mutations within two C/EBP sites were crippled in their ability to replicate in U937 promonocy

68 inity of Cdc42 for intersectin, yet severely cripples interaction with Dbs, a normally potent exchang

69 Fortuitous yet crippling interactions between an IRES and surrounding h

70 Sli15 phenocopies mutations that selectively cripple Ipl1 kinase activation.

71 hey had overwhelming air superiority and had crippled Iraq's command and control capability).

72 thionine-binding site of PRMT1 substantially crippled its nuclear receptor coactivator activity.

73 cterized as interacting with Hoxc-8 and then crippling its DNA-binding ability.

74 redominant nuclear localization of Tmod-1 by crippling its nuclear export mechanism.

75 ally, as evidenced by the noted functionally crippling lesions within various major organ systems of

76 a significant step forward in overcoming the crippling limitation of nitrogenase's sensitivity toward

77 Between 5 and 4 thousand years ago, crippling megadroughts led to the disruption of ancient

78 ation and few mtDNA repair mechanisms exist, crippling mitochondrial mutations are exceedingly rare.

79 els, which then signaled via PKA and Epac to cripple MPhi phagocytosis and interfered with cytoskelet

80 new connection between dormancy, ABA, and a cripple mucilage formation due to a naturally occurring

81 is a dramatic neuromuscular disease in which crippling muscle weakness is evident from birth.

82 us (CHIKV), a reemerging arbovirus, causes a crippling musculoskeletal inflammatory disease in humans

83 as a second-site reverent when catalytically crippled mutants, E165D and H95N, were subjected to rand

84 se of hemorrhagic strokes that may result in crippling neurological deficits.

85 he central nervous system are among the most crippling neurological diseases affecting patients at va

86 Crippled, non-replicative viruses have been used as vect

87 owever, tumors often evade immune control by crippling normal DC function.

88 ogates the SUMO conjugation pathway, broadly crippling nuclear function in proliferating cells of the

89 rgeting of this axis was associated with the crippling of several other signaling axes.

90 et for induction of CXCR3 downregulation and crippling of Th1 cells.

91 ations that either restored the asymmetry or crippled one PIF binding site.

92 The United States is undergoing a crippling opioid epidemic, spurred in part by overuse of

93 e were replaced with oligo-U loops, severely crippling or ablating the native RNA splicing function.

94 euronal function and survival and often have crippling or fatal consequences.

95 us, in these selected cancer cells, either a crippled ORC lacking ORC2 and ORC5 and present at minima

96 identify new therapeutic strategies for this crippling orphan disease, we have performed array based

97 ly 50 years ago in two sisters with a severe crippling osteolysis.

98 ts in the solution-phase and subsequently to crippling overpotentials.

99 ds to compromised p53 acetylation as well as crippled p53 transcriptional activation, accumulation an

100 ds to compromised p53 acetylation as well as crippled p53 transcriptional activation, accumulation, a

101 The hallmark of alphavirus disease is crippling pain and inflammation of the joints, a similar

102 The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an e

103 , and debilitating arthritis associated with crippling pains that persist for weeks and even years.

104 he past century, several have developed into crippling pandemics, including the SARS-CoV-2 virus.

105 r hexamethylene amiloride than were the more crippled parental viruses with the single alanine insert

106 A crippled parvovirus vector was constructed, based on a c

107 ly, selective disruption of this short-helix crippled PDLIM2 in shutting Tax to the nuclear matrix fo

108 ording to Krauss, this left a void that will cripple, perhaps fatally, any early effort to ensure lon

109 nction to alter host actin dynamics and thus cripple phagocytosis.

110 tal inflammatory responses and concomitantly crippling phagocytosis, a primary mechanism used by thes

111 iability and one mutation (H424A) yielding a crippled phenotype across all viruses tested.

112 idues resulted in viruses with significantly crippled phenotypes and proteins that failed to assemble

113 e most common group O alleles share a common crippling polymorphism, a growing number of alleles feat

114 some patients with COVID-19 pneumonia, which cripples primary type I interferon immunity and usually

115 eous population of natively folded RNAs is a crippling problem encountered when preparing RNAs for st

116 The crippled protease activity of Casp9-TM in the presence o

117 wo-thirds of the Gal4AD (gal4D) results in a crippled protein with only 3% the activity of the wild-t

118 Social anxiety disorder (SAD) is a crippling psychiatric disorder characterized by intense

119 ties of existing analysis platforms, thereby crippling real-time analysis of viral evolution(5).

120 Conversely, loss of nuclear IL-33 cripples recruitment, dramatically suppresses glioma gro

121 e Rbf1, but strikingly, these mutations also cripple repression activity.

122 hat delta hly and prfA mutants were the most crippled, requiring 100-fold more mutant bacteria than w

123 oduce IL-5, IL-13, and IL-22 and resulted in crippled responses to intestinal infection with Citrobac

124 ry (92.6% vs 63.0%; P = .001), and long-term crippling sequelae (55.6% vs 15.2%; P < .001).

125 the high proportion (55.6%) of patients with crippling sequelae.

126 ance against T cell-mediated killing because crippling signaling capacity of B7-H1 but not PD-1 ablat

127 bditis elegans C02H7.2 expressed a series of crippling substitutions in the matrix, strongly suggesti

128 restore Ser51 phosphorylation by PKR with a crippled substrate-binding site.

129 ER-associated degradation (ERAD) factors are crippled, suggesting that reflux may work in parallel wi

130 ertional intolerance is a limiting and often crippling symptom in patients with chronic thromboemboli

131 measuring and understanding some of the most crippling symptoms of some of the most debilitating illn

132 ET, APE, lamins, and histones, are likely to cripple the cellular repair response to promote cell dea

133 PKR mutations that cripple the eIF2alpha-binding site impair phosphorylatio

134 The possibility to cripple the function of the PRC2 complex by interfering

135 ks that accompany altered cellular states to cripple the host cell that has been converted into a vir

136 Here, we show that V679A and R695H cripple the ICA domain, blocking the auto-cleavage of My

137 the deterioration of adjacent joints and may cripple the long-term function of the lower extremity.

138 tuberculosis might be assisted by drugs that cripple the pathway by which Mtb buffers, sequesters, an

139 ative action in the admissions process would cripple the profession's ability to achieve racial and e

140 native receptor interactions, however, would cripple the virus for growth in production cells.

141 ervoirs can trigger public health crises and cripple the world economy.

142 lternatives for remote sample collection has crippled the ability for mobile practitioners in human a

143 mutations and histone deacetylase mutations crippled the association of Tup1 with target loci.

144 Yeast producing DppIVA crippled the recruitment and differentiation of monocyte

145 d by insertion of arginines, which initially crippled the resulting protein, but red fluorescence cou

146 ired for interaction with compound I-XW-053, crippled the virus at an early, preintegration step.

147 at the carboxyl end of the cytoplasmic tail cripples the ability of EBV to cause lymphoblastoid cell

148 ssion of multiple virulence determinants and cripples the ability of the organism to adapt to the hos

149 on of specific amino acids within this motif cripples the antitumor actions of GRIM-19.

150 nation and degradation of p53 by Hdm2, which cripples the cellular p53-mediated antiviral response.

151 deed, a dominant negative mutant of KCNQ4_v1 cripples the currents of the entire KCNQ4 channel family

152 us deletion of the S1 and KH domains further cripples the enzyme with respect to RNA substrates.

153 ene encoding NIK in alymphoplasia (aly) mice cripples the function of NIK in p100 processing, causing

154 argeted mutation in Gata4 (Gata4(ki)), which cripples the GATA4-FOG2 interaction, exhibit a profound

155 astates families and entire communities, and cripples the health care system.

156 ebilitating disease that in its final stages cripples the patient.

157 Crippling the AdnA phosphohydrolase active site did not

158 ) IL-27 exerts immunosuppressive activity by crippling the Ag processing machinery in immature DCs un

159 srupts a motif uniquely conserved in Pol IV, crippling the enzyme's ability to inhibit retrotransposo

160 he virus usually wins the race, irreversibly crippling the immune system before an effective cellular

161 Crippling the program genetically or pharmacologically i

162 ed the attenuation of the Deltalpp mutant by crippling the spread of the double mutant to the periphe

163 curative strategies aimed at eliminating or crippling the viral cccDNA.

164 ertebrate host must adapt to host efforts to cripple their viability.

165 was diminished when we mutated the TATA box, crippling transcription.

166 g RAS mutations may propagate immunoglobulin-crippled tumour cells, which usually represent a minorit

167 s accessibility control element function and cripples V(D)J recombination of chromosomal gene segment

168 hemical reductants rescued the catalytically crippled variant form in both of these reactions.

169 virus trigger cellular defense responses to cripple viral replication, and viruses have evolved coun

170 placement of all three cysteines resulted in crippled virus with significantly reduced yields.

171 genous NEDD4L inhibited the release of these crippled viruses and led to cytokinesis defects.

172 n the HOSCN-generating system was completely crippled when deletion of HOSCN reductase activity was c

173 WI/SNF, whereas the functioning of ARS121 is crippled when SWI/SNF is inactivated.

174 evolutionised management of elderly patients crippled with arthritis, with very good long-term result

175 Both pseudogene exons are multiply crippled with RNA splice sites destroyed, and open readi