ライフサイエンスコーパス: critical

1 ow channels/tubing where bubble formation is critical.

2 implications, communicating about science is critical.

3 the glutamate decarboxylase enzyme GAD67, a critical actor of the gamma-aminobutyric acid (GABA) met

4 This study represents a critical advancement toward making squid genetically tra

5 oding with L1 or L2 regularization-each have critical and complementary blind spots under these condi

6 of functional human microproteins that play critical and diverse cellular roles.

7 Pre-mRNA processing of these genes is critical and mediated by HUA-PEP activity, composed of g

8 These recordings revealed a critical and selective role for K(v)1 channel inactivati

9 efined as outcomes scoring greater than 90% "critical" and less than 15% "not important" and were inc

10 elop management recommendations based on (1) critical appraisal of scientific literature; (2) clinica

11 of microbial networks which addresses these critical aspects of the data while maintaining computati

12 Above the critical bacterial volume fraction needed to decrease th

13 ly dependent on circadian clocks to regulate critical behaviors, such as foraging orientation and nav

14 This critical behaviour is confined to a small area in the de

15 by deploying a surface groove to capture the critical BH3 alpha-helix of pro-apoptotic members.

16 small multimeric assemblies appears to be a critical biophysical feature for engendering inherent ac

17 st complex solid state molecular motion is a critical but underexplored phenomenon.

18 Additionally, we confirm critical cancer driver genes by analysing cell-line data

19 ed the importance of raising awareness among critical care clinicians and key stakeholders, advocatin

20 Trauma resuscitations are complex critical care events that present patient safety-related

21 to significantly influence the pace of tele-critical care growth and adoption.

22 a plethora of challenges including acute and critical care management, long-term care and rehabilitat

23 t from editors at 31 respiratory, sleep, and critical care medicine journals to consolidate contempor

24 n, Focused Professional Practice Evaluation, critical care medicine, healthcare quality, and The Join

25 e providers of established U.S. and Canadian critical care organizations and provides a research agen

26 ed core outcome set is lacking for pediatric critical care outcomes.

27 ressure (BP) management is a crucial part of critical care that directly affects morbidity and mortal

28 ed frequently severe complications requiring critical care that induced significant short- and long-t

29 ides analyses and perspective of a survey of critical care workforce, workload, and burnout among the

30 mplete segregation of the operating theater, critical care, and inpatient ward areas) or no defined p

31 venteen experts had subspecialty training in critical care.

32 lls, we postulated that increases in cAMP, a critical cellular "second messenger," may be linked to c

33 A critical challenge for GWASs has been the dependence on

34 mation of memory for a novel experience is a critical cognitive capacity.

35 We will provide a critical comparison between growth pathways in vapour- a

36 The Tns1 protein product is a critical component of focal adhesions linking signaling

37 pre-translational splicing defects may be a critical component of the disease mechanism associated w

38 Therefore, dust was a critical component of the early Earth system, and should

39 Mitochondrial activity is a critical component of tumor metabolism, with profound im

40 Ionizable cationic lipids are critical components involved in nanoparticle formulation

41 g factor (CRF), which has been identified in critical components of the reward circuitry and interact

42 points and World Health Organization interim critical concentrations (CCs) for categorizing clinical

43 Of critical concern are the consequences of these changes o

44 a linear stability analysis we identify the critical conditions triggering channel formation and the

45 iseases and predict mortality of patients in critical conditions.

46 n wide band gap materials, for instance, are critical constituents for the realisation of quantum tec

47 ot significantly associated with a severe or critical COVID-19 event (HR, 1.10; 95% CI, 0.73 to 1.60)

48 tion associated with oil yield in a globally critical crop.

49 r suppressor in liver cancer and establish a critical crosstalk between hepatocyte metabolism and HSC

50 in response to cocaine experience and embed critical cue-associated memory traces that promote cocai

51 ng on Li(3) PS(4) SSE achieves a record-high critical current of >6 mA cm(-2) even at a high capacity

52 nowledge of the native structure can provide critical, detailed information on folding free energy la

53 DSB strand exchange and homolog pairing as a critical determinant for recombination outcome.

54 findings indicate that timing of stress is a critical determinant of the pathology produced in the ad

55 However, CPR duration remains a critical determinate of survival.

56 This notwithstanding, there remain critical development issues and knowledge gaps in SC dru

57 Near the critical drive, time crystal behavior emerges, in which

58 ed the transcription factor NFE2L2/NRF2 as a critical driver of erythrophagocytes, and Nfe2l2/Nrf2 de

59 Oncogenic KRAS, a critical driver of pancreatic cancer, promotes metabolic

60 Ral GTPases have been implicated as critical drivers of cell growth and metastasis in numero

61 family of models that spans a continuum from critical dynamics to asynchronous dynamics.

62 n and monitoring of anticoagulants remains a critical element of high-quality care for patients with

63 y enable mRNA circularization, an apparently critical element of mitochondrial mRNA stability and qua

64 we identify SLC35B2 and myosin-7B (MYO7B) as critical endocytosis regulators for alpha-Syn preformed

65 Subsequently, the critical enzymatic reaction conditions were established,

66 Here, we have examined a critical enzyme, 3-deoxy-d-arabino-heptulosonate 7-phosp

67 The results provide critical evidence that spindles during overnight sleep m

68 ice with regard to its dependency on several critical experimental factors, including the time interv

69 gh-level first-principles simulations of all critical experimental steps, distinctive roaming signatu

70 on and low risk of fetal demise with FAV are critical factors for obtaining a survival benefit.

71 LD was associated with overexpression of the critical fatty acid uptake and de novo lipogenesis genes

72 ion selectivity index, and it reproduces the critical finding with contrast-reversing gratings that r

73 These data from a limited cohort provide a critical first step in understanding the earliest immune

74 logic data collection and analysis, which is critical for a data-driven response to this public healt

75 , neuronal loss rather than inflammation was critical for AD progression in this mouse model, and tha

76 hese findings uncover molecular determinants critical for agonist binding and biased signaling throug

77 risk operate in signal transduction networks critical for both cortical development and synaptic home

78 s of the murine Esco2 active site cleft, are critical for catalysis.

79 Chromatin organization is critical for cell growth, differentiation, and disease d

80 The response to DNA damage is critical for cellular homeostasis, tumor suppression, im

81 ession of a network of transcription factors critical for chordoma survival and upregulated pathways

82 hat contains RTF1, a dissociable PAF subunit critical for chromatin transcription.

83 e branching microtubule nucleation, which is critical for chromosome segregation.

84 rrent study suggests that CD4(+) T cells are critical for controlling acute-stage poliomyelitis (gray

85 These results indicate that CFH is critical for controlling complement activation in the li

86 volution reaction (HER) in alkaline media is critical for developing anion exchange membrane electrol

87 stimation of transcript isoform abundance is critical for downstream transcriptome analyses and can l

88 We observed that CD11c(+) APCs are critical for early priming of CD8 T cells against the im

89 uli to be modified by previous experience is critical for efficient sensory processing and improved b

90 We propose that DCL5 and 24-nt phasiRNAs are critical for fertility under growth regimes for optimal

91 As this pathway is critical for fungal cell wall integrity, the hexosamine

92 in the mouse accessory olfactory system, is critical for interpreting social chemosignals.

93 malian cells, NF2's lipid-binding ability is critical for its function in activating the Hippo pathwa

94 ng multiple activities of complex enzymes is critical for life, including transcribing, replicating a

95 detection of Acinetobacter baumannii (AB) is critical for limiting healthcare-associated infections a

96 trix (ECM) and DNA epigenetic regulation are critical for maintaining stem cell phenotype and cancer

97 hat toll-like receptor 2 (TLR2) signaling is critical for nerve injury-induced activation of spinal c

98 Myelin plasticity is critical for neurological function, including learning a

99 Brain dopamine is critical for normal motor control, as evidenced by its i

100 2) its functional dependence on amino acids critical for OGT activity, and 3) its ability to O-fucos

101 ing preexisting and de novo immunity will be critical for our understanding of susceptibility to and

102 hat are part of a novel motif, EXEXXXL(725), critical for PC7 activity on hTfR1.

103 pression and activity of deubiquitinases are critical for physiology and can go awry in various disea

104 icroenvironment in combination with STAT5 is critical for post-thymic gammadeltaT17 development and t

105 Understanding these patterns is critical for predicting the effects of future climate an

106 Detecting pathogens in trade is critical for preventing their continued movement and int

107 y to identify single-nucleotide mutations is critical for probing cell biology and for precise detect

108 Gratitude and joy are critical for promoting well-being.

109 ighly correlated electrical activity that is critical for proper maturation and circuit refinement.

110 easing measurement sensitivity is especially critical for proteomics research, especially when proces

111 Plant identities critical for retaining interaction diversity are similar

112 effects in low-loss optical fibers which is critical for scalability of real applications with large

113 OSCA1.3 and its phosphorylation by BIK1 are critical for stomatal closure during immune signalling,

114 tination but not proteasomal degradation was critical for structural and functional presynaptic CB(1)

115 Decisions about when to act are critical for survival in humans as in animals, but how a

116 Animal-mediated pollination is critical for sustaining agricultural economies and biodi

117 of both cofilin and actin revealed residues critical for sustaining or abrogating the light- and str

118 ependent of visual experience, experience is critical for the alignment of these early representation

119 , these findings suggest that cholesterol is critical for the cannabinoid-GlyR interaction in the cel

120 t-switchable subunits in a confined space is critical for the design of synthetic molecular machines.

121 events at the airway epithelial surface are critical for the development of the disease.

122 Mix23 is critical for the efficient import of proteins into the m

123 he hypothesis that LC projections to CeA are critical for the expression of defensive responses elici

124 aused by mutations in a transcription factor critical for the function of thymus-derived regulatory T

125 Human neutrophils are critical for the innate immune response to S. aureus inf

126 lamin A/C, an intermediate filament protein critical for the interphase nuclear architecture, was re

127 th actin or its associated proteins are also critical for the localization and activity of synaptic n

128 success at marginal temperatures will become critical for the long-term persistence of many plant spe

129 n) and the presence of BRCA1-bound RAP80 are critical for the normal interaction of BRCA1 with some o

130 s or away from the observer) was found to be critical for the recognition of fear and anger.

131 target binding properties of antibodies are critical for their efficacy and toxicity.

132 es converge on high expression of HOX genes, critical for their self-renewal.

133 essel development in prenatal mice and it is critical for their survival postnatally.

134 These findings suggest that ILC1s are critical for tissue protection during acute liver injury

135 capsid identified several residues that are critical for transduction, capsid assembly, or DNA packa

136 Reporting the sex of biological material is critical for transparency and reproducibility in science

137 Reprograming of proline metabolism is critical for tumor growth.

138 Human ventral temporal cortex (VTC) is critical for visual recognition.

139 A. fumigatus biofilm maturation and are both critical for, and the result of, A. fumigatus late-stage

140 Here we identify a novel and critical function of IKK2 and its co-factor NEMO in the

141 he community structure and productivity of a critical functional group, independent of live coral los

142 To fill this critical gap, we developed a 2D implementation of the Re

143 of flavonoid metabolites revealed potential critical genes involved in flavonoids biosynthesis.

144 t seek to improve outcomes for children with critical illness and their families.

145 with a 3% (95% CI, 0.96-0.97) lower adjusted critical illness mortality within a non-minority-serving

146 ative hypoglycemia in diabetic patients with critical illness.

147 e patterns exist in diverse presentations of critical illness.

148 s history of VTE; thrombophilia; malignancy; critical illness; and infections.

149 ion observed across various murine models of critical illnesses is associated with increased vascular

150 , this three-electrode configuration will be critical in achieving reliable neurotransmitter detectio

151 euse and knowledge discovery is increasingly critical in modern science, and requires an effort towar

152 Enhanced surface mobility is critical in producing stable glasses during physical vap

153 le describes how institutional generosity is critical in supporting health care workers and in enabli

154 gulates nearly all cellular processes and is critical in the development and function of the nervous

155 ene rings of spicy compounds were fund to be critical in the spicy sensing process.

156 the stepwise condensation, thereby providing critical information for a variety of applications, incl

157 These findings provide critical information for sample size calculations of clu

158 ectromicroscopy imaging system to reveal the critical information from the molecular level to meso- a

159 Our approach provides critical information on how subtle changes in protein pr

160 The retrospective data here suggest a critical infusion time for infection reduction (24.6 min

161 Our study provides critical insight into drivers of key flowering phenophas

162 to A. fumigatus Together, these data provide critical insight into the initial epithelial host respon

163 Our results provide critical insights into the phase separation of cellular

164 ive decline in aging populations may provide critical insights into the precursors of late-life demen

165 ich carboxyl-terminal domain 2 (CITED2) as a critical intrinsic negative regulator of inflammation, w

166 tion, and maintenance) framework to identify critical issues for continued program utilization.

167 VID-19, lung transplantation (LTx) remains a critical life-saving operation.

168 ation data to identify patients admitted for critical limb ischemia between 2005 and 2014.

169 A critical limitation preventing the development of curati

170 iven scission of the O-H bond in H(2) O is a critical, limiting step in plasmonic photosynthesis.

171 We identified YAP as a critical mediator of ERBB2 signalling.

172 landins, thromboxanes, and leukotrienes, are critical mediators of physiological processes, such as i

173 In bile, these exist as micelles above their critical micellar concentration (CMC).

174 experimental approaches allow assessment of critical microenvironmental signals controlling hybrid E

175 There is a critical need to better understand the neural basis of a

176 and control mental information, and that the critical neuroanatomical substrates of g and working mem

177 ts the central innate immune system during a critical neurodevelopmental period.

178 These results reveal that ACC is a critical node in model-based control, with a specific ro

179 We also reveal a critical, noncatalytic role for Exo1, through noncanonic

180 Capture and release of peptides is often a critical operation in the pathway to discovering materia

181 Identification of these loops is a critical part of most Hi-C analyses.

182 c signaling, through Cx43 hemichannels, as a critical pathway in leader cell function and collective

183 ce during a discrete developmental time, the critical period, trigger robust changes in the visual co

184 Unregulated stress during critical periods of development is proposed to drive def

185 Additionally, a critical perspective of how the aggregation of CuNCs can

186 inoglycan (GAG)-protein interactions mediate critical physiological and pathological processes, such

187 The hypothesis that water has a second critical point at deeply supercooled conditions was form

188 shown to determine the relaxation above the critical point.

189 onfigurations on either side of a mechanical critical point.

190 MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene express

191 for the identification and quantification of critical quality attributes of biotherapeutics.

192 des of research have shown that the NAc is a critical region influencing addiction, mood, and food co

193 um berghei CDK-related kinase 5 (CRK5), is a critical regulator of atypical mitosis in the gametogony

194 lytic activity toward its substrate Notch, a critical regulator of B cell and T cell development.

195 The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis.

196 g AAA-ATPase enzyme Katanin is emerging as a critical regulator of MT dynamics.

197 These studies confirm the critical requirement of having at least three substituen

198 o rethink approaches to sustaining long-term critical research in the field, ultimately maximizing th

199 tant genomes, we demonstrated that Y138 is a critical residue for Brd4 association and that inability

200 play between N and P availability with other critical resources on seasonal dynamics of ecosystem pro

201 ntrol its own activities but also to trigger critical responses promoting homeostasis in its host.

202 Finally, we offer a critical review and highlight several emerging approache

203 This critical review discusses how the need for reduced clini

204 In this critical review, we focus on the definition of sequence

205 In this critical review, we used hypothetical reverse mutations

206 en used unbiased proteomics and discovered a critical role for emc1 in WNT signaling.

207 icrobe, Guo, Kasahara et al. (2020) reveal a critical role for pDCs in antifungal immunity.

208 Collectively, these findings establish a critical role for Prdm12 in the anorexigenic neuron iden

209 Here, we report a critical role for proline catabolism in non-small cell l

210 Taken together, these results suggest a critical role for skeletal muscle lamin A/C to prevent c

211 her the content of response feedback plays a critical role for the acquisition and long-term retentio

212 actor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung i

213 two invariant histidine residues that play a critical role in catalytic activity.

214 MAF1 is a phosphoprotein that plays a critical role in cell growth control as the central regu

215 Microglia and macrophages play a critical role in choroidal neovascularization (CNV) and

216 It is now apparent that p53 plays a critical role in controlling immune recognition and resp

217 Promoters serve a critical role in establishing baseline transcriptional c

218 member 2) has recently been shown to have a critical role in granulopoiesis in humans, mice, and zeb

219 Immune microenvironment plays a critical role in lung cancer control versus progression

220 Electron-electron interactions play a critical role in many condensed matter phenomena, and it

221 Microglia play a critical role in many processes fundamental to learning

222 yer of soil surrounding plant roots, plays a critical role in plant's adaptation to the environment.

223 Aurora B kinase has a critical role in regulating attachments between kinetoch

224 re, we report that CD2 costimulation plays a critical role in target cell killing by freshly isolated

225 nteractions in the PTC and demonstrate their critical role in termination.

226 The Akt/mTOR pathway played a critical role in the AML-EV-induced phenotypical and fun

227 astrocytes are urgently needed, given their critical role in the central nervous system.

228 l neurons, we show here that tamalin plays a critical role in the ligand-dependent internalization of

229 explain how periodic microstructures play a critical role in the midinfrared.

230 y and reinforces the concept that RA plays a critical role in the pathophysiology of arrhythmogenesis

231 been linked to flash droughts and can play a critical role in the spread of human ignited wildfires.

232 Hence, Dot1l plays a critical role in the thermogenic program and may present

233 TING (stimulator of interferon genes) play a critical role in vascular inflammation and destruction.

234 In summary, our results identify a critical role of CXCR6 in the development of inflammatio

235 These findings support a critical role of DBP in migraine susceptibility and shar

236 sient absorption spectroscopy, elucidate the critical role of electron transfer (ET) from CdS NRs to

237 retrievable biofluids (e.g., sweat), play a critical role, because they can be deployed at a large s

238 stages of differentiation autophagy plays a critical role.

239 coding RNA molecules have been implicated in critical roles covering a broad range of biological proc

240 Src family kinase Lck plays critical roles during T cell development and activation,

241 22-regulated functions in vitro demonstrated critical roles for USP22 in prostate cancer.

242 putative SNX-BAR ligands, many of which play critical roles in apoptosis, cell adhesion, signal trans

243 ssing factors, these regulatory RNAs perform critical roles in gene expression.

244 logical stresses, support biofilms, and play critical roles in interactions between bacteria and thei

245 f biochemical signaling in neurons and plays critical roles in neuronal function.

246 cetylate histone lysine side chains and play critical roles in regulating gene transcription.

247 and HSL1-dependent histone methylation plays critical roles in regulation of seed dormancy during see

248 The oxytocin receptor (OTR) plays critical roles in social behavior development.

249 Together, our study uncovers critical roles of the actin bundler T-Plastin to promote

250 read modification of DNA that plays numerous critical roles.

251 eractions with the ATP-pocket and mediates a critical salt bridge with a glutamate (Glu130) of alphaC

252 The critical Set1 RxxxRR motif adopts a helix that mediates

253 native method whereby tumor cells escape the critical shortening of telomeres.

254 ous throughout the nervous system, mediating critical signal transmission and integration, as well as

255 essure myography, we found that loss of this critical signaling cascade exaggerated the vasoconstrict

256 on to its barrier function, the NE acts as a critical signaling node for a variety of cellular proces

257 although incidence might not exhibit typical critical slowing down properties before a critical trans

258 Below a lower critical solution temperature (LCST), they are highly so

259 P) channel inhibition reduces V O(2) max and critical speed during treadmill running in rats due, in

260 at diverged ~500 million years ago, during a critical stage of vertebrate evolution when image-formin

261 TJ), strongly implicating TJ disruption as a critical step in antigen responsiveness.

262 tem, termed neurulation in vertebrates, is a critical step in embryogenesis.

263 whose disruption leads to fitness defects, a critical step in identifying candidate cancer targets.

264 ) to terminally-differentiated myocytes is a critical step in skeletal muscle development and repair.

265 3D-SMART represents a critical step towards the untethering of single molecule

266 Raman and near-IR) highlighting a series of critical steps, such as preprocessing, data selection, f

267 atched systems produces dislocations above a critical strain energy to release the accumulated strain

268 th burst nucleation of nanoparticles above a critical supersaturation reproduced key features of the

269 The brain is a critical target for developmental endocrine disruption,

270 Coefficients from these models, i.e. critical temperature (T(crit) ) and the initial response

271 resulting metal-organic ferrimagnets feature critical temperatures up to 242 degrees C and a 7500-oer

272 tion of anticancer immunotherapy during this critical time frame could potentially improve patient ou

273 deep soil water acquisition (WA(deep) ) are critical to a species' adaptation to drought.

274 ctic, therapeutic and curative strategies is critical to address this burden but is predicated on a d

275 It is thus critical to assess these terms across all size categorie

276 cale energy storage is becoming increasingly critical to balancing renewable energy production and co

277 It is critical to ensure transgender women are aware of and ha

278 arly disease detection and diagnosis remains critical to ensuring favorable outcomes for patients.

279 CD4(+) T cells are critical to fighting pathogens, but a comprehensive anal

280 r patients with possible sepsis is therefore critical to finding the best balance between assuring im

281 Though critical to health, little research has targeted the eff

282 umor resistance to T cell immunotherapies is critical to improve patient outcomes.

283 Microresonator solitons are critical to miniaturize optical frequency combs to chip

284 Thus, CUL3 is critical to neural development, neurotransmission, and e

285 reat, highlighting the outstanding questions critical to our understanding of this potential risk to

286 Efficient wound repair is critical to reestablish the mucosal barrier and homeosta

287 fying traits that convey resilience to OA is critical to the continued success of abalone and other s

288 ing of structure-reactivity relationships is critical to the design and optimization of cysteine-targ

289 Such improved understanding is critical to the development of new antibiotics that disr

290 tensity, and frequency of control efforts is critical to the management of biological invasions in a

291 A motif (-GPAGTG(6)K(7)S-) were found to be critical to the PI5P-binding ability.

292 nism of nonequilibrium ET dynamics, which is critical to uncovering the molecular nature of many biol

293 xamined in refugee populations, yet they are critical to understand granular health trends.

294 rrently resides in the atmosphere, and it is critical to understand how soil greenhouse gas (GHG) emi

295 lerosis and its complications is, therefore, critical to understanding and treating the disease.

296 Further validation work is critical to unleashing the full potential of coagulation

297 , necessary for indelible expression of this critical transcription factor.

298 al critical slowing down properties before a critical transition, the rate of incidence does, present

299 de, highlighting the need to investigate the critical uncertainties regarding pathophysiology, risk f

300 Exposure to thalidomide during a critical window of development results in limb defects i