ライフサイエンスコーパス: critical illness

1 e patterns exist in diverse presentations of critical illness.

2 and the interhospital variation in prolonged critical illness.

3 h increased mortality in pediatric influenza critical illness.

4 uscripts evaluating outcomes after pediatric critical illness.

5 development of interventions after pediatric critical illness.

6 nts could be predicted in adult survivors of critical illness.

7 ociated with worse long-term cognition after critical illness.

8 ity and cognitive impairment in survivors of critical illness.

9 making throughout the longitudinal course of critical illness.

10 geal injury impacts functional recovery from critical illness.

11 sociated with the impaired FGF19 response in critical illness.

12 among sepsis survivors who developed chronic critical illness.

13 is a rarely seen in adults often leading to critical illness.

14 lated quality of life and survival following critical illness.

15 tically linked to gallbladder dysmotility in critical illness.

16 12 Mental Component Summary scores following critical illness.

17 osure devastate the intestinal microbiome in critical illness.

18 ion and treatment of intestinal dysbiosis in critical illness.

19 s for future research about fluid therapy in critical illness.

20 ion-making over the longitudinal course of a critical illness.

21 age among older (>/= 65 yr old) survivors of critical illness.

22 neficial or adverse effects in patients with critical illness.

23 organ dysfunction are predictive of chronic critical illness.

24 s a risk factor for delirium and coma during critical illness.

25 e meaningful measure of renal function after critical illness.

26 are neuroprotective in preclinical models of critical illness.

27 ss syndrome and is associated with degree of critical illness.

28 cid homeostasis and in muscle wasting during critical illness.

29 its acute and chronic metabolic role during critical illness.

30 recovery and 25 (19%) progressed to chronic critical illness.

31 who received mechanical ventilation during a critical illness.

32 ciated with the onset and clinical course of critical illness.

33 alth-related quality of life in survivors of critical illness.

34 inical severe infection but without signs of critical illness.

35 treatment of hyponatremic encephalopathy in critical illness.

36 d thrombocytopenia in surgical patients with critical illness.

37 hese metabolic pathways, are elevated during critical illness.

38 y might be particularly weak in survivors of critical illness.

39 patient-specific diagnosis and treatment of critical illness.

40 le novel biomarkers and biologic targets for critical illness.

41 ter major noncardiac surgery associated with critical illness.

42 ter the risk of depression and anxiety after critical illness.

43 management of injury and repair responses in critical illness.

44 ight-dark patterns may support recovery from critical illness.

45 are associated with delirium duration during critical illness.

46 en's hospitals and outcomes in children with critical illness.

47 prominent role in the delayed recovery from critical illness.

48 nctional capacity is commonly impaired after critical illness.

49 g of the transition from acute to persistent critical illness.

50 hey open up a new area for drug discovery in critical illness.

51 GLN requirements may increase with critical illness.

52 ticles investigating bone pathophysiology in critical illness.

53 rden of cardiovascular and noncardiovascular critical illness.

54 factor for adverse events among survivors of critical illness.

55 inical severe infection but without signs of critical illness.

56 odel for evaluation of novel therapeutics in critical illness.

57 ssion rhythms rapidly become abnormal during critical illness.

58 largely to multisystem organ involvement and critical illness.

59 ative hypoglycemia in diabetic patients with critical illness.

60 needed to validate its use in the setting of critical illness.

61 betic patients but remains unexamined during critical illness.

62 and the broader transcriptome after onset of critical illness.

63 known about frailty that develops following critical illness.

64 OVID-19) remain unresponsive after surviving critical illness.

65 ation]; 237 men) of whom 168 (47%) developed critical illness.

66 on cognitive function in adult survivors of critical illness.

67 itically ill patients at different phases of critical illness.

68 Frailty is common among survivors of critical illness.

69 ognitive instrument used and the etiology of critical illness.

70 y overestimating the attributable effects of critical illness.

71 e indicates that many patients survive their critical illness.

72 dently of respiratory status and severity of critical illness.

73 population and similar to other survivors of critical illness.

74 different pathological conditions, including critical illnesses.

75 sses are shared across disease etiologies in critical illnesses.

76 following: 1) Frontiers in the management of critical illness; 2) Biogenesis, characterization, and f

77 ts who met a consensus definition of chronic critical illness (26 patients) and a matched sample who

78 ce care in the ICU before developing chronic critical illness (26 patients).

79 g the clinical management of patients with a critical illness(3).

80 somatosensory functions between survivors of critical illness 6 months after ICU discharge and contro

81 We examined almost 1.1 million critical illness admissions among 208 ICUs from across t

82 Prolonged critical illness after congenital heart surgery dispropo

83 ticenter cohort enrolling adult survivors of critical illness after respiratory failure and/or shock

84 Surgical patients who develop chronic critical illness after sepsis exhibit high healthcare re

85 ne the incidence and risk factors of chronic critical illness after severe blunt trauma.

86 Mortality after critical illness among older adults varies by insurance

87 Critical illness among patients hospitalised with COVID-

88 improves clinical outcomes of patients with critical illness and (2) to define the underlying mechan

89 sepsis patients; 63 (36%) developed chronic critical illness and 110 (64%) exhibited rapid recovery.

90 ratory pressure of 14 cm H2O at the onset of critical illness and 26.7% received rescue oxygenation t

91 mass and function is a common consequence of critical illness and a range of chronic diseases, but th

92 ral, and emotional changes, can occur during critical illness and appear as clinically similar to del

93 njury is a common and severe complication of critical illness and cardiac surgery.

94 COVID-19 and is likely to be associated with critical illness and death.

95 these metabolites also distinguished between critical illness and health.

96 families from harm that is both inherent to critical illness and iatrogenic.

97 n predisposes patients to the development of critical illness and increases mortality.

98 Since hemodynamic shock associated with critical illness and infectious epidemics such as Dengue

99 port to patients and families facing chronic critical illness and inform interventions to support sur

100 be particularly beneficial in the setting of critical illness and injury.

101 leading cause of infection in the setting of critical illness and injury.

102 unocompetent children with influenza-related critical illness and is associated with bacterial coinfe

103 rticles using key words related to pediatric critical illness and outcome domains.

104 treatment of the septic patient with chronic critical illness and persistent inflammation-immunosuppr

105 cal cognitive and social status arising from critical illness and persisting beyond hospital discharg

106 entially preventable predictors of prolonged critical illness and prolonged critical illness mortalit

107 enal replacement therapy predicted prolonged critical illness and prolonged critical illness mortalit

108 understudied source of clinical variation in critical illness and represents a novel therapeutic targ

109 s vary widely in their glycaemic response to critical illness and response to insulin therapy.

110 the usefulness of iron-chelating therapy in critical illness and sepsis.

111 Insights from her own encounter with critical illness and study of disturbance and recovery l

112 infusion can suppress plasma glucagon during critical illness and study the role of illness-induced g

113 t seek to improve outcomes for children with critical illness and their families.

114 rly changes in bone functional properties in critical illness and their relationship to changes in bo

115 of frailty that develops as the result of a critical illness and to identify modifiable risk factors

116 anemia treatment in chronic kidney disease, critical illness, and cancer, finding the appropriate in

117 OR for bleeding, 3.56 [95% CI, 1.01-12.66]), critical illness, and death.

118 icting coagulation-associated complications, critical illness, and death.

119 ed chronic pain is a frequent consequence of critical illness, and its impact on daily life of affect

120 diac conditions, such as pulmonary embolism, critical illness, and sepsis, probably cause more of the

121 ndrome is common in children recovering from critical illness, and several risk factors are predictiv

122 s history of VTE; thrombophilia; malignancy; critical illness; and infections.

123 ood-brain barrier/neurological injury during critical illness are associated with prolonged delirium

124 Murine models of critical illness are commonly used to test new therapeut

125 Secondary forms of liver injury in critical illness are divided primarily into cholestatic,

126 mechanisms underlying the susceptibility to critical illness are poorly understood.

127 sical rehabilitation and mobilization during critical illness are safe and feasible, but little is kn

128 Renal outcomes after critical illness are seldom assessed despite strong corr

129 Rationale: Poor outcomes of adults surviving critical illness are well documented, but data in childr

130 Typical for critical illnesses are substantial alterations within th

131 2 hours as independent predictors of chronic critical illness (area under the receiver operating curv

132 ritical care physicians recognise persistent critical illness as a specific syndrome, yet few data ex

133 othalamic releasing factors on recovery from critical illness as well as on long-term rehabilitation

134 We identify two consistent subgroups of critical illness based on serum transcriptomics and deri

135 ng 165 adult patients with H1N1pdm09-related critical illness between September 2013 and March 2014,

136 understanding of the neurobiology following critical illness, both in early and in adult life, may l

137 More children are surviving critical illness but are at risk of residual or new heal

138 rcadian rhythm rapidly dampens with onset of critical illness, but the effect of critical illness on

139 Critical illness can affect patients' respiratory drive

140 Critical illness can cause severe cognitive impairments.

141 present(1), and drives mortality(2), in the critical illness caused by coronavirus disease 2019 (COV

142 activation has been described in adults with critical illness caused by diverse etiologies, especiall

143 rvivors now progress into a state of chronic critical illness (CCI) and their post-discharge outcomes

144 on an explorative clinical study of chronic critical illness (CCI) patients aimed at assessing the l

145 calorie intake via the enteral route during critical illness compared with a lesser amount of calori

146 cresol sulphate, and formate were reduced in critical illness compared with healthy children.

147 of host injury and inflammation during acute critical illness compared with hypoinflammatory patients

148 The heterogeneity of critical illness complicates both clinical trial design

149 ort caregivers of patients who have survived critical illness; consequently, the caregivers' own heal

150 mproved ability to predict impairments after critical illness could guide clinical decision-making, i

151 hospitals with lower-than-expected prolonged critical illness could lead to broader quality improveme

152 ze, and to treat this aspect of the COVID-19 critical illness course, which is becoming more prevalen

153 Compared with noncardiac critical illness, critically ill postoperative cardiac s

154 The prolonged critical illness cutoff (90th percentile length of stay)

155 ent subgroups with shared clinical course in critical illness deciphering disease heterogeneity.

156 We aimed to define prolonged critical illness, delineate between nonmodifiable and po

157 pothesized that individuals hospitalized for critical illness develop greater cognitive decline compa

158 ith 70% of recommended calorie intake during critical illness does not improve quality of life or fun

159 in the study and treatment of patients with critical illness due to COVID-19.

160 nting, treating, and promoting recovery from critical illness due to pulmonary disease are foundation

161 Among CMV-seropositive adults with critical illness due to sepsis or trauma, ganciclovir di

162 reventive strategies to reduce the burden of critical illness, educate our noncritical care colleague

163 e data streams will advance understanding of critical illness, enable real-time clinical decision sup

164 es and prevalent prediabetes in survivors of critical illness experiencing stress hyperglycemia and t

165 rance of cortisol is markedly reduced during critical illness, explained by suppressed expression and

166 In this article, the investigators examine critical illness factors associated with these adverse o

167 Wide variation of prolonged critical illness frequency suggests that identifying pra

168 ad lower- and higher-than-expected prolonged critical illness frequency.

169 Survivors of sepsis and other forms of critical illness frequently experience significant and d

170 Risk factors for critical illness from SARS-CoV-2 infection include male

171 comes between subjects who developed chronic critical illness (>= 14 ICU days with persistent organ d

172 Those who developed chronic critical illness had significantly fewer hospital-free d

173 ency of acquired liver injury and failure in critical illness has been significantly increasing over

174 Survivors of critical illness have an increased prevalence of bone fr

175 d impact on daily life of chronic pain after critical illness have not been systematically studied.

176 fundamental importance of our patients' pre-critical illness health status, their intrinsic suscepti

177 nd altered mucosal immunity in patients with critical illness holds great promise to develop targeted

178 cheostomy and dysphagia often coexist during critical illness; however, given the patient's medical c

179 as associated with higher rates of severe or critical illness (HR, 2.10; 95% CI, 1.50 to 3.10).

180 in medical intensive care units with chronic critical illness (i.e., adults mechanically ventilated f

181 nivariable analysis, a risk model to predict critical illness (ie, death and/or intensive care unit a

182 During critical illness, impaired endothelial vascular reactivi

183 validated, or updated for impairments after critical illness in adult patients.

184 of the microbiome has prevented or modulated critical illness in animal models and clinical trials.

185 ted with susceptibility to influenza-related critical illness in children or with critical illness se

186 Delirium is a prevalent complication of critical illness in children, with identifiable risk fac

187 describes evidence linking risk factors for critical illness in COVID-19 with increased Th17 cell ac

188 Survivors of critical illness in early life are at risk of long-term-

189 ings obtained at admission was predictive of critical illness in hospitalized patients with coronavir

190 d laboratory markers at admission to predict critical illness in hospitalized patients with COVID-19.

191 ired systemic capillary leak associated with critical illness in humans.

192 between FIB-4 and the risk of progression to critical illness in middle-aged patients with COVID-19.

193 ant from specific physiological responses to critical illness in this population and the nature of th

194 ental health, and physical impairments after critical illness in whom screening is recommended.

195 iremia was associated with increased age and critical-illness in ICU at time of transplant and was in

196 t that elevated glucagon availability during critical illness increases hepatic amino acid catabolism

197 Weakness induced by critical illness (intensive care unit acquired weakness)

198 ortality is low after severe trauma, chronic critical illness is a common trajectory in survivors and

199 Chronic critical illness is a global clinical issue affecting mi

200 New-onset atrial fibrillation during critical illness is an independent risk factor for morta

201 Critical illness is associated with a disturbed regulati

202 status at hospital discharge in survivors of critical illness is associated with increased postdischa

203 Financial toxicity related to critical illness is common and may limit patients' emoti

204 The prolonged phase of critical illness is hallmarked by a uniform suppression

205 RATIONALE: Critical illness is hallmarked by muscle wasting and dis

206 Assessing outcomes after pediatric critical illness is imperative to evaluate practice and

207 on of glucagon and its metabolic role during critical illness is lacking.

208 le understanding of outcomes after pediatric critical illness is limited by heterogeneity in methodol

209 Critical illness is not a discrete disease state or synd

210 mpairment after major noncardiac surgery and critical illness is not associated with the surgery and

211 The central role of the microbiome in critical illness is supported by a half century of exper

212 comes for those aged 18 years and older with critical illness is unclear.

213 outcomes in nonimmunosuppressed adults with critical illness is unknown.

214 cal significance of altered lung bacteria in critical illness is unknown.Objectives: To determine if

215 ion observed across various murine models of critical illnesses is associated with increased vascular

216 ypolipidemia, which may occur with trauma or critical illness, is clinically associated with bacteria

217 ctioning is central to patient recovery from critical illness-it may enable the ability to determine

218 ernal causes of circadian arrhythmia include critical illness itself and subjective experience of dis

219 ts and neuromuscular dysfunction acquired in critical illness; limitations include studies with a hig

220 Host genetic variants associated with critical illness may identify mechanistic targets for th

221 Obesity and critical illness modify pharmacokinetics of antibiotics,

222 ted prolonged critical illness and prolonged critical illness mortality in both strata.

223 actors), whereas only one of eight prolonged critical illness mortality predictors was nonmodifiable.

224 Over the last 10 years, although the risk of critical illness mortality steadily decreased by 2% per

225 Cardiac ICU prolonged critical illness mortality was 24% in neonates and 8% in

226 with a 3% (95% CI, 0.96-0.97) lower adjusted critical illness mortality within a non-minority-serving

227 of prolonged critical illness and prolonged critical illness mortality, and understand the interhosp

228 longed critical care therapy drive prolonged critical illness mortality.

229 ibution from critical illness polyneuropathy/critical illness myopathy and severe sepsis/septic shock

230 patients for critical illness polyneuropathy/critical illness myopathy and those with severe sepsis/s

231 tic brain injury (n = 96), general pediatric critical illness (n = 87), and congenital heart disease

232 After critical illness, new or worsening impairments in physic

233 Although bleeding frequently occurs in critical illness, no published definition to date descri

234 can amplify all complement activity, during critical illness.Objectives: We examined the function an

235 f 356 patients would be predicted to develop critical illness, of which 59 (83%) would be true-positi

236 Patients with chronic critical illness often exhibit "a persistent inflammatio

237 the increase in vasopermeability induced by critical illness often results in significant fluid over

238 dy of literature has shown that survivors of critical illness often struggle with cognitive impairmen

239 potential relationship between the impact of critical illness on cognitive function and employment st

240 onset of critical illness, but the effect of critical illness on gene expression oscillations is unkn

241 of critically ill adults who develop chronic critical illness or die in an ICU.

242 ausible factors related to sepsis-associated critical illness organ dysfunction and its treatment wer

243 tudy using data from the multicenter, cohort Critical Illness Outcomes Study.

244 At 4 months, chronic critical illness patients had higher mortality (16.0% vs

245 At 3- and 6-month follow-up, chronic critical illness patients had significantly lower physic

246 By 12-month follow-up, chronic critical illness patients had significantly lower physic

247 Chronic critical illness patients were more likely to be dischar

248 s 5% and 0.4%, respectively, in nonprolonged critical illness patients).

249 arrest, adult cardiac arrest, and pediatric critical illness peer-reviewed published literature.

250 ssess the impact of a discharge diagnosis of critical illness polyneuromyopathy on health-related out

251 r abnormalities and a discharge diagnosis of critical illness polyneuropathy and/or myopathy along wi

252 nical importance of a discharge diagnosis of critical illness polyneuropathy and/or myopathy and the

253 athy, patients with a discharge diagnosis of critical illness polyneuropathy and/or myopathy had fewe

254 national database, a discharge diagnosis of critical illness polyneuropathy and/or myopathy is stron

255 to patients without a discharge diagnosis of critical illness polyneuropathy and/or myopathy, patient

256 7 ICU patients with a discharge diagnosis of critical illness polyneuropathy and/or myopathy, we matc

257 ts who did not have a discharge diagnosis of critical illness polyneuropathy and/or myopathy.

258 showed a disproportionate contribution from critical illness polyneuropathy/critical illness myopath

259 ribution from studies examining patients for critical illness polyneuropathy/critical illness myopath

260 is associated with improved survival during critical illness, possibly because of enhanced immune ca

261 Although many prolonged critical illness predictors are nonmodifiable, we identi

262 Approximately 40% of the prolonged critical illness predictors were nonmodifiable (preopera

263 ied 10 neonatal and 19 nonneonatal prolonged critical illness predictors within strata and eight pred

264 , especially the aged, are suffering chronic critical illness, rarely fully recover, and often experi

265 Case-mix-adjusted prolonged critical illness rates were compared across hospitals; s

266 to clinicians caring for adult survivors of critical illness related to screening for postdischarge

267 atements for the diagnosis and management of critical illness-related corticosteroid insufficiency (C

268 and understanding of the pathophysiology of critical illness-related corticosteroid insufficiency (C

269 ts and neuromuscular dysfunction acquired in critical illness remains unclear.

270 nefits of vitamin D supplementation in acute critical illness require further study.

271 ng endotracheal intubation may be related to critical illness severity and to preexisting hypoxemia.

272 tration, rather than traditional measures of critical illness severity, should be considered in ident

273 related critical illness in children or with critical illness severity.

274 ated with IFITM3 expression levels, nor with critical illness severity.

275 in would decrease the time that survivors of critical illness spent in delirium or coma.

276 e presence of Redondoviridae associates with critical illness such as respiratory failure and periodo

277 Critical illness such as sepsis is a life-threatening sy

278 red mechanism preventing full recovery after critical illnesses such as acute respiratory distress sy

279 Vascular leakage is a characteristic of critical illnesses such as septic shock and acute respir

280 Critical illness survivors (n = 84) and controls (n = 44

281 ion during hospitalization among nonsurgical critical illness survivors over the past decade.

282 Study in critical illness survivors.

283 es is essential to improving the outcomes of critical illness survivors.

284 , the most severe toxicity, presents a novel critical illness syndrome with limited data regarding di

285 pression, or post-traumatic stress disorder) critical illness that can be used to identify patients a

286 isorder were found to be common 1 year after critical illness, the occurrence of delirium during ICU

287 Following nonsurgical critical illness, the prevalence of functional status de

288 n, gastroduodenal ulcers, rehospitalization, critical illness, thrombocytopenia, blood dyscrasias, he

289 Despite the elevated cortisol levels during critical illness, tissue resistance to glucocorticoids i

290 disease 2019 (COVID-19) vs those with other critical illness to better characterize the contribution

291 xiety (state and trait) were assessed during critical illness using the Faces Anxiety Scale and the t

292 In univariable modeling, critical illness variables associated with death and/or

293 ted in trauma patients who developed chronic critical illness versus rapid clinical recovery.

294 Chronic critical illness was defined as an ICU stay lasting 14 d

295 Reduction in employment after critical illness was present in the majority of our ICU

296 Patients who developed chronic critical illness were older (55 vs 44-year-old; p = 0.01

297 g the development and persistence of chronic critical illness will be necessary to improve long-term

298 severe form of tuberculosis and often causes critical illness with high mortality.

299 ric patients with SARS-CoV-2 are at risk for critical illness with severe COVID-19 and MIS-C.

300 ly 100% of recommended calorie intake during critical illness would increase quality-of-life scores,