ライフサイエンスコーパス: critical role in

1 s an NAD(+)-dependent deacetylase that plays critical roles in a broad range of biological events, in

2 ng RNAs (lncRNAs) have been revealed to play critical roles in a wide variety of biological processes

3 portions of the hemagglutinin protein play a critical role in achieving fusion.

4 aris IFG, PMv and IPL, each of which plays a critical role in action perception and execution.

5 Thyroid hormone signaling plays a critical role in activating M-opsin and repressing S-ops

6 The acquisition of mutations plays critical roles in adaptation, evolution, senescence, and

7 genetic mechanisms have been shown to play a critical role in adaptive and maladaptive processes by r

8 CD8(+) T cells play a critical role in adaptive immunity, differentiating into

9 B lymphocytes play a critical role in adaptive immunity.

10 n of C/EBPbeta and C/EBPdelta, PAGR1 plays a critical role in adipogenesis.

11 heir role in development, neurotrophins have critical roles in adult brain plasticity.

12 actor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung i

13 he dysregulation of neuronal iron may play a critical role in Alzheimer's disease.

14 inositide 3-kinase (PI3K)/Akt, which plays a critical role in angiogenesis.

15 putative SNX-BAR ligands, many of which play critical roles in apoptosis, cell adhesion, signal trans

16 rm" region that studies have shown to play a critical role in assembly.

17 Smooth muscle cells (SMC) play a critical role in atherosclerosis.

18 us ceruleus (LC) activity, as the LC plays a critical role in attentional modulation.

19 are a family of mammalian kinases that have critical roles in autophagy and development.

20 MENT Dopamine signals in the striatum play a critical role in basal ganglia function, such as reinfor

21 t suggest that H2AX ADP-ribosylation plays a critical role in base excision repair (BER).

22 lear despite that soil microorganisms play a critical role in biogeochemical cycling.

23 Tumor associated macrophages (TAMs) play a critical role in biology of various cancers, including b

24 n the ligand and cobalt in Co(II)CPY plays a critical role in boosting its activity.

25 d effect on the urinary phenotype due to its critical roles in both the formation and the maintenance

26 vides in vivo evidence that RAD51AP1 plays a critical role in breast cancer growth and metastasis by

27 ce indicates that the nervous system plays a critical role in cancer progression.

28 The accumulation of somatic mutations plays critical roles in cancer development and progression.

29 mily encompasses several proteases that play critical roles in cancer progression; however, the expre

30 Our study demonstrates that FTO plays critical roles in cancer stem cell self-renewal and immu

31 are essential cellular organelles that play critical roles in cancer.

32 ct air capture (DAC) is positioned to play a critical role in carbon removal, yet remains under paced

33 ough degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease.

34 Magnesium ions play a critical role in catalysis by many enzymes and contribut

35 two invariant histidine residues that play a critical role in catalytic activity.

36 MAF1 is a phosphoprotein that plays a critical role in cell growth control as the central regu

37 nto distinct cytoskeletal structures plays a critical role in cell physiology, but how proteins local

38 Multisite protein phosphorylation plays a critical role in cell regulation [1-3].

39 gen) is a hemidesmosomal protein and plays a critical role in cell-cell matrix adhesion in the skin;

40 The Hippo pathway plays critical roles in cell growth, differentiation, organ de

41 Super enhancers (SEs) play critical roles in cell type-specific gene regulation.

42 ubiquitous and have a much broader range of critical roles in cells than was initially thought.

43 nastomoses or pial collateral vessels play a critical role in cerebral blood flow (CBF) restoration f

44 Microglia and macrophages play a critical role in choroidal neovascularization (CNV) and

45 es of some native-like nucleosomes that play critical roles in chromatin functions.

46 lity may signify a previously underestimated critical role in circadian influences on long-term retin

47 conferred by the extended linker can play a critical role in circumventing this unproductive reactio

48 complex-dependent actin nucleation, plays a critical role in CNS myelination, and its absence leads

49 thalamus and prefrontal cortex (PFC) play a critical role in cognitive function and arousal.

50 dings reveal that VAN signaling also plays a critical role in cognitive processes, including affectiv

51 a-catenin (CTNNB1) signaling pathway plays a critical role in colorectal carcinogenesis.

52 Freeze-thaw cycle dynamics play a critical role in controlling cold season CO(2) and CH(4)

53 piRNAs, however, have a critical role in controlling histone gene expression.

54 It is now apparent that p53 plays a critical role in controlling immune recognition and resp

55 This barrier plays a critical role in controlling the acquisition of nutrient

56 The marine phosphorus cycle plays a critical role in controlling the extent of global primar

57 tional regulation of gene expression plays a critical role in controlling the inflammatory response.

58 of the Wnt/beta-catenin pathway, which plays critical roles in CRC pathogenesis.

59 The prefrontal cortex (PFC) plays a critical role in curbing impulsive behavior, but the und

60 ade by key brain genes-stoichiometry-plays a critical role in defining the clinical features of autis

61 the notion that species interactions play a critical role in determining upslope range limits.

62 investigation, these carriers clearly play a critical role in determining what an insect can smell.

63 Just as research played a critical role in developing early EHR prototypes and dem

64 RNA-binding proteins (RNA-BPs) play critical roles in development and disease to regulate ge

65 Primary cilia play critical roles in development and disease.

66 HMG-box repressor Capicua (Cic), which plays critical roles in development and is deregulated in huma

67 ed in peripheral and neuronal cells, playing critical roles in development, physiologic processes, an

68 ghly versatile signaling system, which plays critical roles in developmental morphogenesis as well as

69 cally assessed by flow cytometry and plays a critical role in diagnosis, classification, and prognosi

70 The size of the cycloalkene rings plays a critical role in dictating the product distributions of

71 d with TBI, where acute inflammation plays a critical role in disease progression.

72 ARS-CoV-2 asymptomatic infections may play a critical role in disease transmission.

73 functions define cellular identity and have critical roles in diseases such as cancer, although the

74 on site and mitotic microtubules and plays a critical role in division plane orientation in plants.

75 l K29-linked ubiquitination by USP36 plays a critical role in DNA replication stress and chemotherapy

76 region indicated that these proteins play a critical role in driving in vivo fitness and virulence o

77 tomotor, and posterior insula regions play a critical role in dysconnectivity shared across deletions

78 ine, disproportionately affecting genes with critical roles in early brain development, and leading i

79 mics and adaptor protein concentrations play critical roles in EGFR signaling.

80 a central transport hub in the cell, with a critical role in endocytic trafficking and endoplasmic r

81 namide adenine dinucleotide (NAD(+)) plays a critical role in energy metabolism and bioenergetic home

82 hat RSK2 (p90 ribosomal S6 kinase 2) plays a critical role in ER stress-induced autophagy in breast c

83 Promoters serve a critical role in establishing baseline transcriptional c

84 hat the mIgE B-cell antigen receptor plays a critical role in establishing or maintaining the populat

85 However, other cell types play critical roles in establishing where a lesion is conduci

86 The orbitofrontal cortex (OFC) plays a critical role in evaluating outcomes in a changing envir

87 The basolateral amygdala (BLA) plays a critical role in fear conditioning and is extremely sens

88 National Institutes of Health (NIH) plays a critical role in funding scientific endeavors in biomedi

89 Direct Cx43 interaction with ZO-1 plays a critical role in gap junction regulation.

90 ssing factors, these regulatory RNAs perform critical roles in gene expression.

91 The deep sea plays a critical role in global climate regulation through uptak

92 member 2) has recently been shown to have a critical role in granulopoiesis in humans, mice, and zeb

93 ntial for early mammalian development, plays critical roles in GSC maintenance and M2-like TAM polari

94 Feature screening plays a critical role in handling ultrahigh dimensional data ana

95 Cholesterol plays two critical roles in Hedgehog signaling, a fundamental path

96 transmission of BMF, thereby confirming its critical role in hematopoiesis in humans.

97 GABA interneurons play a critical role in higher brain functions.

98 aryote-specific appended domain also plays a critical role in hLysRS nuclear localization, thus facil

99 Macrophages play critical roles in homeostasis and inflammation.

100 culosis exposure and whether such AwM play a critical role in host defense against M. tuberculosis in

101 In contrast, contextual valence plays a critical role in how the PL is recruited in initiating o

102 Our data show that MN1 plays a critical role in human craniofacial and brain developmen

103 Also, bacteria have critical roles in human health as pathogens and commensa

104 or histocompatibility complexes (MHC) play a critical role in immune cell recognition and can trigger

105 umor-associated macrophages (TAMs) playing a critical role in immune suppression.

106 te blood cells of the immune system and play critical roles in immune cell signaling.

107 ells are CD4(+) effector T cells that play a critical role in immunity by shaping the inflammatory cy

108 Macrophages are highly plastic cells with critical roles in immunity, cancer, and tissue homeostas

109 nctions are ubiquitous in metazoans and play critical roles in important biological processes, includ

110 tivation and proliferation, supporting their critical roles in in CNS pathogenesis.

111 rated that HIV-induced telomeric DDR plays a critical role in inducing telomere loss, premature cell

112 Microbicides play critical roles in infection prevention and control of Eb

113 Glycosylation within the human host plays a critical role in influenza virus biology.

114 Thus, Chd4 plays a critical role in integrating Fezf2- and Aire-mediated ge

115 logical stresses, support biofilms, and play critical roles in interactions between bacteria and thei

116 Necroptosis signaling pathway plays a critical role in intestinal cell injury.

117 ed members of the RGS family with unique and critical roles in intracellular responses to drugs of ab

118 Phospholipase C, a key enzyme playing critical roles in intracellular signal transduction, is

119 tylases (HDACs), and Tet2 hydroxylase play a critical role in keeping cancer cells in a highly metast

120 poor diagnosis and outcome but also plays a critical role in leukemia transformation and maintenance

121 Instead, I suggest that sodium's critical role in limiting herbivore performance makes it

122 Oxidative stress plays a critical role in liver tissue damage and in hepatocellul

123 Immune microenvironment plays a critical role in lung cancer control versus progression

124 The chloride-proton exchanger CLC-7 plays critical roles in lysosomal homeostasis and bone regener

125 he recent recognition that B cells also play critical role in maintaining peripheral tolerance and su

126 ely, these data demonstrate that WISP1 plays critical roles in maintaining GSCs and tumor-supportive

127 Electron-electron interactions play a critical role in many condensed matter phenomena, and it

128 he function of macrophages (M ) which play a critical role in many physiological processes in healthy

129 Microglia play a critical role in many processes fundamental to learning

130 been identified in cellular RNAs, which play critical roles in many cellular processes, from modulati

131 1 (YAP) is a transcriptional regulator with critical roles in mechanotransduction, organ size contro

132 ly(ADP-ribose) polymerase 1 (PARP1), plays a critical role in mediating IAV HA-induced degradation of

133 iculum (SR) calcium has been shown to play a critical role in mediating mitochondrial dysfunction in

134 hemical cycling, soil microorganisms exert a critical role in mediating the direction and strength of

135 We show that ORAI2 and ORAI3 channels play a critical role in mediating the regenerative Ca(2+) oscil

136 Whether this clustering plays a critical role in membrane fusion is poorly understood in

137 (SWRs), hippocampal population events with a critical role in memory consolidation.

138 r, these findings suggest that SETD6 plays a critical role in memory formation and may act as an upst

139 ty, adult-born neurons (ABNs) in the DG play critical roles in memory; however, their memory function

140 for advanced glycation end-products) play a critical role in metabolic pathways, which we envisage c

141 cancer and bacterial infections due to their critical role in mitochondrial and bacterial proteostasi

142 ogous proteins in eukaryote cells, playing a critical role in mitochondrial fusion.

143 results indicate that astrocytic YY1 plays a critical role in Mn-induced neurotoxicity in vivo, at le

144 mer conditions, while precipitation played a critical role in moderating the balance between concentr

145 te that radiation dose fractionation plays a critical role in modulating levels of KLF2, its upstream

146 r P limitation, we suggest S. bescii plays a critical role in modulating stress imposed by limitation

147 that the focal adhesion kinase Pyk2 plays a critical role in monocyte motility.

148 is strongly argues that the pallidum plays a critical role in motor control, it has been difficult to

149 rces, remains poorly understood, despite its critical role in movement.

150 Autophagy plays critical roles in neurodegeneration and development, but

151 lpha-Synuclein (alpha-syn) pathology plays a critical role in neurodegenerative diseases such as Park

152 ropomyosin receptor kinase B (TrkB), plays a critical role in neuronal proliferation, differentiation

153 f biochemical signaling in neurons and plays critical roles in neuronal function.

154 Visceral adipose tissue plays a critical role in numerous diseases.

155 Ca(2+) plays critical roles in numerous beta-cell pathways such as in

156 hexosamine biosynthetic pathway (HBP) plays critical roles in nutrient sensing, stress response, and

157 MG) in a process termed meibogenesis-plays a critical role in ocular surface physiology.

158 Colorectal Carcinoma (Dcc) receptor plays a critical role in optic nerve development.

159 The Hippo pathway, which plays a critical role in organ size control and cancer, features

160 duced unpairing of the double helix and have critical roles in organizing large-scale chromatin struc

161 Inflammation plays a critical role in osteoarthritis (OA).

162 FXR plays critical roles in other lipid metabolic pathways, includ

163 Chlamydia muridarum, IL-1R signaling plays a critical role in oviduct tissue damage.

164 vaccination, suggesting that cDC1s played a critical role in pDC-mediated cross-priming independent

165 onductance (g(s)); therefore, stomata play a critical role in photosynthesis and transpiration and ov

166 Despite their critical roles in physiology, methods for broad and dire

167 yer of soil surrounding plant roots, plays a critical role in plant's adaptation to the environment.

168 s are dynamic and adaptable organs that play critical roles in plant development.

169 way is essential for organogenesis and plays critical roles in postnatal tissue maintenance and renew

170 ce suggests that SNARE fusion machinery play critical roles in postsynaptic neurotransmitter receptor

171 the host gut mucosal immunity and may play a critical role in precipitating FA.

172 h-temperature superconductivity(4)-and their critical roles in present-day technical devices.

173 of entangled photons in TPA process plays a critical role in probing the detailed electronic structu

174 it signals between synapses and soma, play a critical role in processing functions, such as nonlinear

175 le NAC transcription factor, TaNAC2, plays a critical role in promoting crop growth and nitrogen use

176 immune microenvironment of tumors can play a critical role in promoting or inhibiting tumor progressi

177 The immune system plays critical roles in promoting tissue repair during recover

178 The tumor microenvironment plays a critical role in prostate cancer (PC) development and pr

179 s all non-keratinized epithelia, and plays a critical role in protecting the human body from infectio

180 development are generally understood to play critical roles in protecting societies from the adverse

181 Natural killer (NK) cells play critical roles in protection against hematological malig

182 me, a complex multisubunit protease, plays a critical role in protein degradation.

183 signature that includes genes known to play critical roles in PSCs and synapses.

184 activation of T helper 17 signaling plays a critical role in psoriasis pathogenesis, and systemicall

185 ng mediator in the TLR/IL-1 pathway, plays a critical role in PTB.

186 ep in blood-feeding arthropods, which have a critical role in public health as disease vectors.

187 Twitching motility plays a critical role in redistributing cells on surfaces prior

188 erythroid-2-related factor 2 (Nrf2) plays a critical role in reducing oxidative stress by promoting

189 Aurora B kinase has a critical role in regulating attachments between kinetoch

190 J intercellular communication (GJIC) plays a critical role in regulating behaviors of human embryonic

191 molecule-1 (ICAM-1), a molecule that plays a critical role in regulating blood-to-brain immune cell t

192 MT)-motor-mediated transport dynamics have a critical role in regulating both factors.

193 ically Pcdhgc3, Pcdhgc4, and Pcdhgc5, play a critical role in regulating cIN survival during the endo

194 DNA methylation plays a critical role in regulating gene expression, genomic sta

195 Tgf-beta3 plays a critical role in regulating murine palate development, a

196 central pair apparatus (CPA), which plays a critical role in regulating proper ciliary function.

197 cycle 23 (Cdc23, also known as APC8) plays a critical role in regulating the oocyte chromosome separa

198 e data indicate that phosphorylation plays a critical role in regulating the structure and function o

199 Inhibitory neurons play critical roles in regulating and shaping olfactory respo

200 With critical roles in regulating gene expression, miRNAs are

201 cetylate histone lysine side chains and play critical roles in regulating gene transcription.

202 Cytokines play critical roles in regulating the development, survival,

203 of the mononuclear phagocyte system, playing critical roles in regulating tissue homeostasis and coor

204 Nuclear YAP1 plays a critical role in regulation of stem cell proliferation,

205 and HSL1-dependent histone methylation plays critical roles in regulation of seed dormancy during see

206 Uncertainty plays a critical role in reinforcement learning and decision mak

207 ed potassium 11.1 (K(v)11.1) channels play a critical role in repolarization of cardiomyocytes during

208 The Hippo (MST1/2) pathway plays a critical role in restricting tissue growth in adults and

209 +) from the cytosol into the vacuole plays a critical role in salinity tissue tolerance, but another,

210 duction of urates and renal function plays a critical role in serum uric acid levels.

211 mammalian male-specific Y chromosome plays a critical role in sex determination and male fertility.

212 Dendritic cells (DCs) play a critical role in shaping adaptive immunity.

213 Corneal stiffness plays a critical role in shaping the cornea with respect to intr

214 of NOD2, indicating that MDP sensing plays a critical role in shaping the immune response to intestin

215 subfamily V member 3 (TRPV3) channel plays a critical role in skin physiology, and mutations in TRPV3

216 The hippocampus plays a critical role in sleep-related memory processes [1-3], b

217 The oxytocin receptor (OTR) plays critical roles in social behavior development.

218 ct and energy crisis, and thereby it plays a critical role in solving environmental problems and gene

219 s in the environment and consequently play a critical role in species survival.

220 descriptors of neuron type, but also have a critical role in specifying neuronal identity.

221 ach nucleus transcribes even-skipped plays a critical role in stripe formation.

222 ticity mediated by the GluA1 subunit plays a critical role in sustaining and amplifying seizure activ

223 EphB2 plays a critical role in synaptic development; its potent activa

224 tu generated oxides/hydroxides, which play a critical role in synergistically reducing energetic barr

225 ctively, our results indicate that Yap plays critical roles in T-cell biology and suggest that Yap in

226 re, we report that CD2 costimulation plays a critical role in target cell killing by freshly isolated

227 The results show that S100A4 plays a critical role in tension development in airway SM tissue

228 nteractions in the PTC and demonstrate their critical role in termination.

229 For canid species, scent marking plays a critical role in territoriality, social dynamics, and re

230 m molecules define Tpm continuity and play a critical role in the ability of Tpm to cooperatively bin

231 The Akt/mTOR pathway played a critical role in the AML-EV-induced phenotypical and fun

232 AA unfoldases include spastin, which plays a critical role in the architecture of eukaryotic cells by

233 and the formation of F-actin patches plays a critical role in the assembly of gap junction channels.

234 e that BZR1-dependent ROS production plays a critical role in the BR-mediated regulation of tapetal c

235 Dopamine (DA) plays a critical role in the brain, and the ability to directly

236 astrocytes are urgently needed, given their critical role in the central nervous system.

237 , MAD2L2-containing shieldin complex plays a critical role in the choice between homologous recombina

238 nergic circuit that we identified may play a critical role in the counterregulatory response to hypog

239 TREM-1 plays a critical role in the eCIRP-mediated increase of ICAM-1 e

240 sources of H(2) and abiotic CH(4) have had a critical role in the evolution of our planet and the dev

241 Hepatic LDLr plays a critical role in the flow of macrophage-derived UC to fe

242 ctions within the same beta-sheet may play a critical role in the formation of polymorphic fibrils.

243 For example, iron plays a critical role in the generation of reactive oxygen inter

244 pleting agent, nitrous oxide (N(2)O) plays a critical role in the global climate.

245 phosphate (PLP)-binding proteins that play a critical role in the homeostasis of vitamin B(6) and ami

246 The human cathelicidin LL-37 serves a critical role in the innate immune system defending bact

247 intermediate, and the ligation step plays a critical role in the joining of noncomplementary DNA end

248 l neurons, we show here that tamalin plays a critical role in the ligand-dependent internalization of

249 s located in the lateral hypothalamus play a critical role in the maintenance of arousal and contribu

250 Intracranial pressure monitoring plays a critical role in the management of severe traumatic brai

251 correct, and that solvation dynamics plays a critical role in the mechanism.

252 explain how periodic microstructures play a critical role in the midinfrared.

253 ve activity of parkin has been linked to its critical role in the mitochondria maintenance.

254 The complement system serves a critical role in the modulation of immune response and r

255 mu-Opioid receptors (mu-ORs) play a critical role in the modulation of pain and mediate the

256 NA-dependent protein kinase (DNA-PK) plays a critical role in the non-homologous end joining (NHEJ) r

257 ia/macrophages at the site of injury plays a critical role in the onset of many pathological events f

258 Fibroblast-like synoviocytes (FLS) play a critical role in the pathogenesis of rheumatoid arthriti

259 ed KIF21B autoregulation and function play a critical role in the pathogenicity of human neurodevelop

260 y and reinforces the concept that RA plays a critical role in the pathophysiology of arrhythmogenesis

261 lite, sphingosine 1-phosphate (S1P), plays a critical role in the pDC functions and interferon produc

262 doxal 5'-phosphate-dependent enzyme, plays a critical role in the progression of hepatocellular carci

263 ide-expressing (VIP) interneurons may play a critical role in the proper development and function of

264 Interferon (IFN) type I plays a critical role in the protection of mice from lethal Nipa

265 Consequently, RNA-binding proteins play a critical role in the regulation of mRNA and protein abun

266 piRNAs play a critical role in the regulation of transposons and other

267 been linked to flash droughts and can play a critical role in the spread of human ignited wildfires.

268 synaptic transmission within the NAc plays a critical role in the stress response.

269 Hence, Dot1l plays a critical role in the thermogenic program and may present

270 sulfonated groups and Arg/Lys residues play critical roles in the binding of suramin to the "AT-hook

271 of functionally versatile proteins that play critical roles in the biogenesis, cellular localization

272 N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system.

273 ate, directly interacts with Rab7a and plays critical roles in the control of the endosomal-lysosomal

274 a, RsmA is an RNA-binding protein that plays critical roles in the control of virulence, interbacteri

275 ects of human TREM2 biology that likely play critical roles in the development and progression of AD.

276 bolites, mitonuclear coregulation, and their critical roles in the emergence of metazoans and in huma

277 Autophagy plays critical roles in the maintenance of endothelial cells i

278 iption factors TonEBP and NF-kappaB p65 play critical roles in the switch from osmoadaptive homeostas

279 We tested hypothesis that ANG II plays critical roles in the transcriptional repression of Npr1

280 ns and thus, their genetic diversity plays a critical role in their functions.

281 e in E. coli and S. typhimurium that plays a critical role in their virulence by changing the outer m

282 w that histone acetyltransferase MOF plays a critical role in this process through directly activatin

283 plex by showing that exosite binding plays a critical role in this process, which they describe as a

284 ing cassette (ABC) transporters play several critical roles in this process, and mutations in these s

285 They fulfill critical roles in tissue homeostasis and development and

286 The CSF1-CSF1R pathway has a critical role in trafficking allergens to regional lymph

287 plants and mammals, DNA methylation plays a critical role in transcriptional silencing by delineatin

288 membrane of epithelial cells, where it has a critical role in transport.

289 Hospital systems play a critical role in treating injuries during disaster emerg

290 nd extracellular matrix (ECM), which plays a critical role in tumor initiation, progression, metastas

291 The tumor microenvironment (TME) plays critical roles in tumor growth and progression, however

292 The extracellular matrix (ECM) plays critical roles in tumor progression and metastasis.

293 are frequently hijacked in cancer and play a critical role in tumorigenesis.

294 Multiple-choice examinations play a critical role in university admissions across the world.

295 complex SWI/SNF is highly conserved and has critical roles in various cellular processes, including

296 TING (stimulator of interferon genes) play a critical role in vascular inflammation and destruction.

297 the Golgi apparatus and is thought to play a critical role in vesicular trafficking.

298 nd Dchs1 knockout mice, we demonstrate their critical roles in villus formation.

299 n the budding and fission yeasts have played critical roles in working out how the eukaryotic cell cy

300 sforming growth factor-beta (TGFbeta) play a critical role in wound healing.