ライフサイエンスコーパス: cross peak

1 ly, and significant narrowing of the His-258 cross-peak.

2 average of nine possible interpretations per cross-peak.

3 methyl groups, of which 612 contribute NOESY cross peaks.

4 ion can be monitored by the movements of the cross peaks.

5 n-water NOEs from alternate exchange-relayed cross peaks.

6 tifies the sequence positions of 1H-15N HSQC cross-peaks.

7 rom inspection of intraresidual (H1',H6) NOE cross-peaks.

8 d a significant number of intermolecular NOE cross-peaks.

9 ngly intense intra- and intermolecular NOESY cross-peaks.

10 221 in PTP1B) to alanine abolished all three cross-peaks.

11 encoded in the signs and intensities of the cross-peaks.

12 y complex perturbs most of the (1)H(N)-(15)N cross-peaks.

13 differences in the number of detectable NMR cross-peaks.

14 formational exchange broadening of all F5 NH cross-peaks.

15 sed dramatic perturbation of most of the NMR cross-peaks.

16 ) have less than half the expected number of cross-peaks.

17 unusual intensities observed for DNA-DNA NOE cross-peaks.

18 R shifts is obtained from the development of cross-peaks.

19 well as interior cellulose-surface cellulose cross-peaks.

20 eled protein show unequivocal attenuation of cross-peaks after membrane binding.

21 A 6-fold increase in cross-peak amplitude was observed in 4-acetylbenzonitril

22 istinguished by examining the time-dependent cross-peak amplitudes for specific excitation and detect

23 , which are subsequently used to reconstruct cross-peak amplitudes of a pseudo-3D data set as a funct

24 relaxation transport in molecules to enhance cross-peak amplitudes.

25 by fitting the mixing time dependence of the cross-peak and diagonal-peak signals to a magnetization

26 d NMR nuclear Overhauser effect spectroscopy cross-peak and hyperfine shift patterns.

27 splitting, amplitude, and line shape of the cross-peaks and diagonal peaks.

28 ed from quantitative simulations of 2QF-COSY cross-peaks and from persistent inconsistencies in exper

29 s, whereas the C-terminal half had fewer NOE cross-peaks and less chemical shift dispersion.

30 While NOE cross-peaks and perturbations of the chemical shifts cle

31 (MQ) spin coherences, which lead to spurious cross-peaks and phase-twisted lines in the 2D (15)N-(13)

32 ined by quantitative simulations of DQF-COSY cross-peaks and used to determine sugar pucker populatio

33 The N-terminal half showed strong NOE cross-peaks and well-dispersed NMR resonances, whereas t

34 f 1H and 15N chemical shifts, sequential NOE cross-peaks, and S2 values of the backbone atoms, and th

35 r the spatial contacts that give rise to the cross peaks are artifacts of sample preparation, we now

36 The cross peaks are observed both at -20 degrees C and at am

37 Cross peaks are selected using local clustering to avoid

38 The resulting cross peaks are used in a simple and direct way to compa

39 The missing cross-peaks are restored upon binding strong agonists su

40 residue 29, together with 85 long-range NOE cross peaks arising from interchain interactions.

41 t example of the observation and analysis of cross-peaks arising from chemical exchange processes inv

42 ed as a function of temperature, showed that cross-peaks arising from the alpha-helical backbone and

43 nterference effects between the diagonal and cross-peaks arising from the sheets, combined with diago

44 o DNA we were able to directly observe three cross-peaks, arising from lysine NH3 groups, with 15N ch

45 complex, were used to classify the exchange cross peaks as follows: (A) a direct NOE with a water pr

46 onventional analysis would have assigned the cross-peaks as being indicative of a chemical exchange p

47 s identified intermolecular pectin-cellulose cross-peaks as well as interior cellulose-surface cellul

48 assignments and extensive analysis of NOESY cross-peak assignments.

49 lution were obtained, exhibiting (19)F-(19)F cross peaks associated with fluorine atoms as far as ~10

50 After binding of ACh, the five cross-peaks associated with cysteines from the C-loop co

51 illatory quantum energy transport but also a cross-peak asymmetry not previously explained by theory.

52 r presence of 50 mm sodium chloride showed a cross peak at 10.25 ppm on the 1H axis and 129 ppm on th

53 tion spectra reveal seven His37 Calpha-Cbeta cross peaks at different pH, some of which are unique to

54 The relative magnitudes of the cross peaks at various population periods measure the pi

55 While Cinn-GEE alone showed a single cross-peak at delta 9.64 ((1)H) and delta 201 ((13)C), t

56 g of selected residues show relatively sharp cross-peaks at chemical shifts that are consistent with

57 PTP1B/Cinn-GEE complex showed three distinct cross-peaks at delta 7.6-7.8 ((1)H) and 130-137 ((13)C).

58 bonded amide(1)H and (15)N spins but also a cross peak between the (1)H chemical shift from bulk wat

59 al station is visible from a newly appearing cross peak between these two moieties.

60 E experiments on 1.3S revealed no detectable cross peaks between biotin and the protein.

61 ncy CN stretching mode contributes to strong cross peaks between CN groups in two different chemical

62 ponding (1)H 2D NOESY NMR spectra display no cross peaks between HPTS and AOT consistent with the HPT

63 In CTAB reverse micelles, clear cross peaks between HPTS and CTAB in the 2D NMR spectra

64 The data showed extensive cross peaks between pectins and cellulose in the primary

65 x of CoA, chloramphenicol and enzyme, 71 NOE cross peaks between protons of coenzyme A and a further

66 mixed, so that only interresidue (13)C-(13)C cross peaks between two differently labeled proteins rep

67 unusual long-range ((5)JH-H) (1)H-(1)H COSY cross-peak between C2-CH3 and C4-H signals.

68 (1)H NMR and ROESY spectra results showed a cross-peak between H-3 proton of beta-cyclodextrin and t

69 We observed a strong intraresidue NOE cross-peak between H1' and H8 of the modified dA(6).

70 ily, the emergence in 2D and 3D spectra of a cross-peak between reactant and product reveals the cis-

71 r characterized by (19)F NMR and show an NOE cross-peak between residues that are located on differen

72 two could be directly determined from NOESY cross-peaks between CH beta protons of the corresponding

73 Nuclear Overhauser enhancement cross-peaks between Co(NH(3))(6)(3+) and the GAAA tetral

74 ed from the intensities of 71 NOE and 33 ROE cross-peaks between coenzyme protons.

75 ween protons of coenzyme A and a further ten cross-peaks between protons of coenzyme A and chloramphe

76 Specifically, we observed strong cross-peaks between the aromatic protons of the Phe ring

77 ase-pairs, no nuclear Overhauser enhancement cross-peaks between the cobalt ligand and neighboring RN

78 NOE cross-peaks between the intercalating phi ligand and pro

79 navalin A, ribonuclease A, and lysozyme show cross-peaks between the IR-active transitions that are c

80 ptide and U46619 using the comparison of the cross-peaks between the NOESY spectra of U46619 with the

81 by intermolecular nuclear Overhauser effect cross-peaks between the peptide and short chain dioctano

82 The cross-peaks between the two arms of the drug are tentati

83 and ion stretches and probing the associated cross-peaks between them, we are afforded a comprehensiv

84 At high GdnHCl concentrations, most cross-peaks broaden and shift, qualitatively indicating

85 multiple spin-spin couplings contributing to cross-peak buildup.

86 most no detectable chemical shift changes of cross-peaks, but some general increase in line width.

87 combination of amide I' and II' diagonal and cross peaks can effectively distinguish between secondar

88 ere we report that chemical exchange-induced cross-peaks can arise in even the simplest two-dimension

89 These cross-peaks can have highly distorted phases that contai

90 The isotope-dependent amide-I/II cross-peaks clearly reveal the existence of vibrational

91 Cross-peak connectivities observed in the nonexchangeabl

92 Cross-peak connectivity in the nonexchangeable proton sp

93 anomalous" spectrum at pH 7.5, which retains cross-peaks consistent with ionized tyrosinate.

94 could have contributed to line broadening of cross-peaks corresponding to helices H10 and H11.

95 Indeed, the cross-peaks corresponding to the rather hydrophobic beta

96 uted for Cys 187 and 188 shows only two main cross-peaks, corresponding to Cys 123 and 136 from the C

97 were used to confirm the assignment of NOESY cross-peaks critical in defining the global fold of the

98 NOE cross-peaks d(alphaN), d(NN), and d(betaN) provided inte

99 (MAUS), leveraging Nuclear Overhauser Effect cross-peak data, peak residue type classification and a

100 termolecular nuclear Overhauser effect (NOE) cross-peaks define a specific complex in which the Co(NH

101 pectroscopy (HYSCORE) spectra exhibit strong cross-peaks demonstrating strong isotropic coupling of t

102 s in multilamellar lipid vesicles, where the cross-peak development arises from the exchange of the n

103 Cross-peak development due to chemical exchange has been

104 D, 3D, and 4D MAS spectra, all of which show cross-peak doubling.

105 Cross-peaks due to gas atoms entering or exiting were ob

106 assignments because of the loss of key TOCSY cross-peaks due to the line broadening from a dynamic he

107 p synthase with 1-15N-L-Trp showed a similar cross peak either in the presence or absence of disodium

108 to protein, oligosaccharide and nucleic acid cross-peak enhancements of ~200-1000% per scan, in measu

109 ysis, we obtained signals with well resolved cross-peak features attributed to the couplings within a

110 alpha-helical FP but weak or no (31)P-water cross peak for neutral membranes containing the beta-she

111 H correlation spectra show clear (31)P-water cross peaks for anionic membranes containing the alpha-h

112 Analysis of the buildup rate of the exchange cross peaks for several base-paired imino protons in the

113 hemical shift and the appearance of multiple cross-peaks for certain residues, suggesting that the do

114 shift-pH titration curves are obtained from cross-peaks for reporter protons in BASHD-TOCSY spectra

115 The absence of amide cross-peaks for residues G13 to H19 in the (1)H-(15)N he

116 oops 2 and 3 and the very weak or missing NH cross-peaks for several residues in loops 1 and 3.

117 py of apo-AChBP revealed seven well resolved cross-peaks for the group of cysteines.

118 beta-sheet of ubiquitin through the loss of cross peaks formed between transitions arising from delo

119 19 cross-peaks found between 9.0 and 11.4 ppm are consisten

120 otropic chemical shift data and interhelical cross peaks from magic angle spinning solid-state NMR of

121 The absence of cross-peaks from [14-(13)C]retinal to [4-(13)C]Asp-85 in

122 In H(2)O the 2D-IR shows cross-peaks from large coupling in the alpha-helical con

123 way, to N-betaGRP results in the loss of NMR cross-peaks from the backbone (15)N-(1)H groups of the p

124 ere acquired and overlaid to distinguish the cross-peaks from the main peaks.

125 s is evident from the significant direct NOE cross-peaks from the protons of Co(NH3)6(3+) to GH8, GH1

126 Following the individual cross peaks, however, is complicated and does not establ

127 e narrowed spectra of acyl-proline-NH(2) and cross peaks implying the coupling between its amide-I mo

128 es in 1D (15)N spectra as well as additional cross peaks in 2D (13)C-(13)C and (13)C-(15)N spectra.

129 py (EXSY) experiment leads to characteristic cross peaks in 2D spectra.

130 and strong water-AFP III and water-ubiquitin cross peaks in frozen solution using relaxation filtered

131 The excellent dispersion of cross peaks in the (1)H-(15)N correlation spectrum is co

132 cific assignments of considerably overlapped cross peaks in the 1H-NMR spectrum of a DNA trinucleotid

133 dependent amplitudes and energy positions of cross peaks in the 2.21/1.85 eV (excitation/detection) r

134 Cross peaks in the 2D correlation plots of the spectra r

135 We observe multiple absorption bands but no cross peaks in the 2D IR spectra, which indicates that t

136 are directly measured through the growth of cross peaks in the 2D-IR spectra of CO bound to the heme

137 ns in the line widths and chemical shifts of cross peaks in the HSQC spectrum of CD2d1 during titrati

138 The intensities and line shapes of the cross peaks in the spectrum reflected the kinetic time c

139 the holo-form, Phe17 shows an extra exchange cross-peak in addition to those exchange cross-peaks obs

140 ven histidine residues gave rise to a single cross-peak in the HMQC spectra, and these were assigned

141 with the observation of strong peptide-water cross-peaks in (1)H spin diffusion spectra, these result

142 Here a procedure for the assignment of cross-peaks in (15)N-(1)H correlation spectra of sparsel

143 dsRNA binding induces exchange broadening of cross-peaks in 1H-15N HSQC spectra.

144 orb infrared light and so can be detected by cross-peaks in 2D SFG spectra.

145 se of polarized pulse sequences to elucidate cross-peaks in 2D spectra has been demonstrated in the I

146 e absence of glycerol and produced dispersed cross-peaks in a (1)H-(15)N heteronuclear single quantum

147 easured the intensity buildup of (13)C-(13)C cross-peaks in a series of 2D (13)C correlation spectra

148 from their resolved CalphaH-CepsilonH2 TOCSY cross-peaks in BASHD-TOCSY spectra.

149 The method assists in the identification of cross-peaks in crowded regions of ROESY spectra by movin

150 e of long-range HSQMBC to address inadequate cross-peaks in HMBC that result from the highly dense qu

151 een CH(3)/CH (positive) and CH(2) (negative) cross-peaks in overcrowded regions.

152 constraints based on the analysis of absent cross-peaks in solid-state NMR correlation experiments.

153 sults in the selective broadening of certain cross-peaks in the 15N-1H heteronuclear single quantum c

154 he internucleotide A4H8-T3H1' and A4H8-T3H3' cross-peaks in the 1:1 complex of this sequence.

155 roborated by DQF-COSY H2/N1H and ROE N1H/N6H cross-peaks in the 2D NMR spectra of Rh2(DTolF)2{d(ApA)}

156 Intense H8/H8 ROE cross-peaks in the 2D ROESY NMR spectrum of Rh(2)(OAc)(2

157 TolF)2{d(ApA)} is indicated by the H8/H8 NOE cross-peaks in the 2D ROESY NMR spectrum, whereas the fo

158 G)] adduct is evidenced by intense H8/H8 ROE cross-peaks in the 2D ROESY NMR spectrum.

159 The absence of H1'-H2' cross-peaks in the 2QF-COSY spectrum indicates a C3'-end

160 terconvert slowly enough to exhibit separate cross-peaks in the amide region of homonuclear and heter

161 A subset of cross-peaks in the HSQC spectrum of p23 is shifted upon

162 here the weak coupling pairs are revealed as cross-peaks in the indirect dimension separated by the i

163 HYSCORE cross-peaks in the proton region were partially overlapp

164 The cross-peaks in the pure heterodimer 2D IR difference spe

165 ve analysis also identifies vulnerable CH(2) cross-peaks in the standard ME-HSQC that coincide with C

166 ocket, 16 residues had weak or no detectable cross-peaks in the two-dimensional 1H-15N HSQC spectrum

167 The experimental data show no cross-peaks in the twodimensional photocurrent spectra,

168 emonstrate how the structural sensitivity of cross-peaks in two-dimensional correlation plots of chir

169 For AFP III, the water cross peaks indicate that only a portion of its hydratio

170 (2)H distance measurements and (1)H-(1)H NOE cross peaks indicate that the adamantane moiety of the d

171 oton chemical shift and the intensity of the cross-peak indicate a very short hydrogen bond to the ca

172 The disappearing cross-peaks indicate interactions between the beta(2) an

173 lation intensity between the two alpha-helix cross peaks indicated that the more hydrophobic helix fr

174 uronan is extracted retains cellulose-pectin cross peaks, indicating that the cellulose-pectin contac

175 ite, shows two sets of side-chain (15)N-(1)H cross-peaks, indicating conformational flexibility.

176 han for interior cellulose-surface cellulose cross-peaks, indicating that pectins come into direct co

177 ion of the nitrogen-amide proton correlation cross-peaks indicative of a pure, uniformly labeled mole

178 Analysis of cross peak intensities in two-dimensional NMR spectra of

179 uld be estimated from the NOESY diagonal and cross peak intensities.

180 x shows only one set of NMR signals, and the cross-peak intensities are rather uniform, suggesting th

181 oduces complex two-dimensional spectra whose cross-peak intensities are related to correlations in th

182 ensities, and (ii) they significantly reduce cross-peak intensities for strongly J-coupled (13)C site

183 om total relaxation matrix analysis of NOESY cross-peak intensities in restrained molecular dynamics

184 The cross-peak intensities of the loop region in scalar corr

185 The Tr-NOESY cross-peak intensities provided proton-proton distance c

186 Distance restraints were calculated from NOE cross-peak intensities via a complete relaxation matrix

187 A comparison of relative RFDR cross-peak intensities with simulations of the NMR exper

188 lete relaxation matrix analysis of the NOESY cross-peak intensities with the program MARDIGRAS.

189 tion and prohibit the extraction of reliable cross-peak intensities, and (ii) they significantly redu

190 n and subsequent analysis of two-dimensional cross-peak intensities, the chemical identity and mass c

191 uclear Overhauser effect (NOE) spectroscopic cross-peak intensities, yielding accurate distance restr

192 ns were in agreement with nuclear Overhauser cross-peak intensities.

193 e inhibitor, the C.H distance based upon the cross-peak intensity being 2.0 +/- 0.4 A.

194 ar NMR showed a steep decrease in (1)H-(15)N cross-peak intensity for 8 residues in the isolated C-te

195 e conventional use of long mixing time NOESY cross-peak intensity, backbone angles, and hydrogenbondi

196 by significant and selective increased NOESY cross-peak intensity, increase in steric Fe-CN tilt refl

197 By reversing the frequency of CH(2) cross-peaks into an empty region, the FR-ME-HSQC method

198 Although some NOE cross-peaks involving protons of the hexakis(ethylene gl

199 The NOESY cross-peaks involving U(33) H2' and characteristic of tR

200 ependence of the intensity of these spectral cross-peaks is consistent with an active site tyrosine w

201 to analyze the relaxation data of the type A cross peaks, it was found that the water molecules had s

202 ollapse of the scalar multiplet structure of cross-peaks leads to a sensitivity gain of about 40-50%

203 romosome 16A1-B1 (DOXNPH locus) in all three crosses [peak logarithm of odds (lod) score of 92.7, P =

204 on, such that robust monoexponential fits to cross-peaks may be used to determine the diffusion coeff

205 d time scale, and misinterpretation of these cross-peaks may lead to erroneous conclusions should the

206 These cross peaks measure the coupling between the different a

207 tios for the C(epsilon 1)-H and C(delta 2)-H cross-peaks measured with a constant time HSQC experimen

208 rom the C-loop condense into two predominant cross-peaks not observed in the spectrum from the apo pr

209 nge cross-peak in addition to those exchange cross-peaks observed in apo-form.

210 design principles as the HISQC, all the NH3 cross-peaks observed in the HISQC spectrum could be assi

211 Anomalous cross-peaks observed in the NOESY spectra of 2,4-disubst

212 by comparisons of experimental and simulated cross-peaks obtained with high digital resolution.

213 Spectrally resolved cross peaks occur in the off-diagonal region of the 2D I

214 n requires nearly complete assignment of the cross peaks of a refined NOESY peak list.

215 anol (TFE) shows that the individual residue cross peaks of IA(3) become more dispersed in the presen

216 ve attenuation in the 1H-15N HSQC spectra of cross peaks of residues at the end of helix 3 (Ser-58, L

217 However, the amide cross-peak of Leu31 demonstrates a significant urea depe

218 An exchange cross-peak of one phenylalanine in the holoprotein is at

219 s challenge can be addressed by using fitted cross-peaks of a reference 2D HSQC experiment as footpri

220 TRNOE cross-peaks of bound PC were confirmed to represent intr

221 , which made possible the measurement of NOE cross-peaks of relatively rapidly exchanging amide proto

222 The majority of the (1)H-(15)N HSQC cross-peaks of the folded state show only a limited chem

223 -exchange spectroscopy between corresponding cross-peaks of the magnetically non-equivalent subunits

224 t and intensity decrease of the diagonal and cross-peaks of the sheet's two IR active modes.

225 experiment(s) by superimposing the expected cross-peaks on the mixture spectrum.

226 s, and in each case we see the appearance of cross-peaks on the timescale of a few picoseconds, signa

227 The 2D ES show marked cross-peak oscillations assigned to electronic and vibra

228 Cross-peak oscillations originate from a vibrational wav

229 and presence of glucose, reveal significant cross-peak overlap and heterogeneous peak intensities th

230 c C terminus, is highly flexible, exhibiting cross-peak patterns and transverse relaxation rates that

231 NOE cross-peak patterns in 2D (12)C/(12)C-filtered NOESY spe

232 Analysis of cross-peak patterns in the 2D spectra supports a previou

233 The NOESY cross-peak patterns indicate that the hydrocarbon is int

234 Comparison of chemical shift and NOE cross-peak patterns indicates that the structures of the

235 The 2QF-COSY cross-peak patterns which are resolved have been analyze

236 are unambiguously identified by their unique cross-peak patterns.

237 pancy between the experimental and simulated cross-peak patterns.

238 3 sequential and medium range intrachain NOE cross peaks per chain, characteristic of alpha-helices e

239 In CCl(4), the computed cross-peak portion of the 2D-IR shows evidence of two am

240 We report the dependence of the diagonal-to-cross-peak ratio on concentration, light intensity, and

241 f sufficiently high quality that many of the cross peaks, recorded previously from malignant cell mod

242 rotein structure indicates that the observed cross-peak reduction is well correlated with a high perc

243 The experiment exposes the cross peaks, representing the mode coupling, free of the

244 The NOE cross-peaks resulting from the interactions between the

245 dard ME-HSQC that coincide with CH(3) and CH cross-peaks, resulting in the loss of critical structura

246 Long-range nuclear Overhauser effect (NOE) cross-peaks showed the two helices to be in near proximi

247 In addition, there are many new cross-peaks, showing that the binding is asymmetric.

248 the HSQC-CLIP-COSY pulse sequence that edit cross-peak signs so that direct HSQC responses can be di

249 Cross-peak-specific 2D electronic spectroscopy provides

250 we develop 2D electronic spectroscopy using cross-peak-specific pulse polarization conditions in an

251 hibit signs of differential line broadening, cross-peak splitting and chemical shift heterogeneity th

252 N line shapes and higher intensities for NH3 cross-peaks than either HSQC or heteronuclear multiple q

253 re only modestly longer for cellulose-pectin cross-peaks than for interior cellulose-surface cellulos

254 lanine produced perturbations of the His-258 cross-peak that were similar to those detected in the E3

255 COLMARq allows the analysis of cross-peaks that belong to both known and unknown metabo

256 Anomalous NOESY cross-peaks that cannot be explained by dipolar cross-re

257 rn delta-proton magnetic anisotropy, and NOE cross-peaks that establish all compounds but 1c and 1g t

258 ion, we are able to isolate sharp difference cross-peaks that report on local changes in vibrational

259 mal shift and intensity and showed clear NOE cross-peaks to C NHb and NHe.

260 Negative and small NOE cross-peaks to other protons in the sequence reveal a no

261 nce, as demonstrated with the observation of cross-peaks to resonances at the frequency of the water

262 multiplets to singlets in the F1 dimension, cross-peaks to the anomeric protons of the two iduronic

263 eous to the excitation, including pronounced cross-peaks to the bend vibration and a continuum of ind

264 d from the sign and magnitude of NOE and ROE cross-peaks to water identified in 2D NOESY and ROESY ex

265 The D/C cross-peak volume ratio was found to be proportional to

266 The D/C cross-peak volume ratios determined for oleic (18:1), li

267 des a large number of accurate values of NOE cross peak volumes in a decoupled HMQC-NOESY spectrum.

268 significant difference (P < .05) between the cross peak volumes measured for healthy subjects and tho

269 tial Halpha-HN to intraresidue HN-Halpha NOE cross-peak volumes support a predominantly extended conf

270 th crystal structures and the fact that this cross-peak was absent in the heteronuclear correlation s

271 om time-dependent shifts of the stretch-bend cross peak, we determined a lower limit on the lifetime

272 Type A and B cross peaks were analyzed using three models of water dy

273 sidue nuclear Overhauser effect spectroscopy cross peaks were observed at 30 degrees C and a 200 ms m

274 Interestingly, few cross- peaks were observed between the proteins and the

275 proximately 90% of the 949 unambiguous NOESY cross-peaks were assigned automatically with simultaneou

276 Mb data sets collected at various pH values, cross-peaks were assigned to the imidazole rings and the

277 Intraligand NOE cross-peaks were detected for the hydroxyl proton in the

278 These cross-peaks were not observed in the NOESY spectra of Me

279 mellar suspensions of MeDOPE, positive NOESY cross-peaks were observed between the downfield-shifted

280 Strong NOESY cross-peaks were observed between the H5 and H1' of N14

281 Three sets of cross-peaks were observed for each nucleus.

282 Strong cross-peaks were observed from the carboxyl carbon to pr

283 For the (31)P couplings, three sets of cross-peaks were observed in the HYSCORE spectrum, and c

284 The intensities of the triple-helical cross-peaks were stronger for the peptide-amphiphile, co

285 tly (15)N-labeled in P. pastoris, and proton cross-peaks were well dispersed in nuclear Overhauser ef

286 n intensity and disappearance of 1H-15N HSQC cross-peaks, were observed with the addition of either s

287 sensitivity, evidenced by 50-100% additional cross peaks, when compared to alternative processing sch

288 of NP2-ImH mutants exhibit chemical exchange cross peaks, whereas WT NP2-ImH shows no chemical exchan

289 in PTP1B) into alanine had no effect on the cross-peaks, whereas mutation of a conserved active-site

290 agonal allows the accurate identification of cross-peaks which are otherwise obscured by the strong a

291 ugs permitted the assignment of drug-protein cross peaks, which indicate that amantadine and rimantad

292 s separated by one or two bonds (2.5 A) show cross peaks, which therefore identify reference intracha

293 dy revealed the presence of interknuckle NOE cross-peaks, which were interpreted in terms of a more c

294 of free [15N]PGH shows a single 1H-15N HMQC cross peak with delta (1H) = 10.3 ppm and delta (15N) =

295 well as arginines, showed intermolecular NOE cross-peaks with D8PG, providing direct evidence for the

296 The sugar H2' and H2' ' of dC(5) lacked NOE cross-peaks with H8 of dA(6) but showed weak interaction

297 with Phe2, Phe47, and Phe62 showing exchange cross-peaks with minor conformation in (19)F-(19)F nucle

298 In comparison, cross-peaks with similar intensities between the two sta

299 y 15N-labeled protein show two well resolved cross-peaks with weak couplings of approximately 0.3-0.4

300 eral unambiguously identified long-range NOE cross-peaks within the loop region and between TM2 and T