ライフサイエンスコーパス: cross-coupling

1 or copper complexes that mediate or catalyze cross coupling.

2 ons: Giese-type addition and Co/Ni-catalyzed cross-coupling.

3 he 5-aza-7-deazapurine moiety by Sonogashira cross-coupling.

4 rnary carbons via Ni-catalyzed Csp(3)-Csp(3) cross-coupling.

5 m AcOH-induced CH(sp(3))-CH(sp(2)) oxidative cross-coupling.

6 2,2'-bipyridine catalyst via radical-radical cross-coupling.

7 electrophiles in transition-metal catalyzed cross-coupling.

8 by Pd-assisted Sonogashira or Suzuki-Miyaura cross-coupling.

9 effective methods for stereospecific Csp(3) cross-coupling.

10 l conjugated diynes through homo-coupling or cross-coupling.

11 reactive activating group for iron-catalyzed cross-coupling.

12 st example of a Ag-mediated Liebeskind-Srogl cross-coupling.

13 acid) and a subsequent functionalization or cross-coupling.

14 e reactions, and nickel-catalyzed C(sp(2))-O cross-coupling.

15 xylates, as related to their role in radical cross-coupling.

16 examples of ligand-controlled chemodivergent cross-couplings.

17 oxymethyl furfural utilizing decarboxylative cross-couplings.

18 ated to provide new opportunities to perform cross-couplings.

19 the active catalyst for these Csp(2)-Csp(3) cross-couplings.

20 asis for the development of C-C bond forming cross-couplings.

21 donor acceptor systems for efficient C-N/C-C cross-coupling, a series of donor acceptor systems DA1-D

22 Herein, we report a sulfur (IV) mediated cross-coupling amendable for the efficient synthesis of

23 ationship (SLR) of amino acids (AAs) for the cross-coupling aminations was examined.

24 c details of iron-catalyzed reductive alkene cross-coupling, an important representative of the HAT a

25 ing solid-phase peptide synthesis, iterative cross-coupling and accessing reactive, unstable diazirin

26 transformations such as C-C and C-heteroatom cross-coupling and C-H functionalization but have until

27 ighted by several transformations, including cross-coupling and carbocyclizations.

28 methyl-4-nitropyrazole and (ii) a three-step cross-coupling and cyclization approach starting from th

29 Ar, silylation, solvolysis, Pd catalyzed C-S cross-coupling and cycloadditions) is demonstrated, high

30 by a cascade of Pd-catalyzed Suzuki-Miyaura cross-coupling and direct arylation reactions.

31 lpha-arylpyrrolidines through Suzuki-Miyaura cross-coupling and enantioselective copper-catalyzed int

32 ne the divergent reactivity from established cross-coupling and hydrofunctionalization reactions, a d

33 nsymmetrical tetrazines through Pd-catalyzed cross-coupling and in the first catalytic thioether redu

34 ive fluorescent dyes via heteroaromatic Heck cross-coupling and N-pyridin-2-yl nucleophilic substitut

35 Reactivity studies in the Suzuki-Miyaura cross-coupling and transamidation reactions provide insi

36 Implications to related Ni-catalyzed radical cross-couplings and the design of new transformations ar

37 ce involving triflate formation, Sonogashira cross-coupling, and regioselective hydrogenation.

38 general use of iodo-BCPs as electrophiles in cross-coupling, and the first Kumada coupling of tertiar

39 lic substitutions, C-H activation reactions, cross-couplings, and intramolecular or intermolecular cy

40 Here we report a non-canonical cross-coupling approach for the construction of anilines

41 This two-step concurrent cross-coupling approach, resembling formal and flexible

42 Still, homogeneous C-N cross-coupling approaches cannot yet employ bases as wea

43 e evolution from classic palladium-catalyzed cross-coupling approaches to more modern oxidative versi

44 Inspired by the advantages of reductive cross-coupling approaches, we present here a highly effi

45 iably join two molecular fragments together (cross-couplings) are essential to the discovery and manu

46 anes, useful motifs for (Z)-selective Hiyama cross-coupling, are accessed from alkynyl benzyldimethyl

47 /photoredox dual catalytic C(sp(2))-C(sp(3)) cross-coupling as well as photoredox-catalyzed radical/p

48 y and can be used to achieve protein-protein cross-coupling at nanomolar concentrations within hours.

49 hloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic h

50 photoredox co-catalyzed asymmetric reductive cross-coupling between alpha-chloro esters and aryl iodi

51 Willis materials exhibit macroscopic cross-coupling between particle velocity and stress as w

52 antio- and diastereoselective Suzuki-Miyaura cross-coupling between racemic fused bicyclic allylic ch

53 A photoassisted Ni-catalyzed reductive cross-coupling between tosyl-protected alkyl aziridines

54 inetically favorable reaction pathway is the cross-coupling between two heterochiral molecules (one o

55 aryl radicals are engaged in (hetero)biaryl cross-coupling, borylation, and hydrogenation in a redox

56 transition metal-mediated C(sp(2))-C(sp(2)) cross-coupling, but this strategy typically requires pre

57 nstrate that LiCl is essential for effective cross-coupling by accelerating the reduction of Ni(II) t

58 nding application in reactions as diverse as cross-coupling, C-H activation, and borylation.

59 The cross-coupling can be telescoped into the one-pot synthe

60 Stereocontrolled Csp(3) cross-coupling can fundamentally change the types of che

61 Catalytic cross-coupling can then furnish the desired Z-homoallyli

62 e reaction was found to be determined by the cross-coupling carbon-carbon bond forming reaction, rath

63 An alkoxycarbonyl radical cyclization-cross-coupling cascade has been developed that allows fu

64 precedented decarboxylative radical addition/cross-coupling cascade of vinyl boronic esters.

65 Mechanistic studies suggested a classical cross-coupling catalytic cycle.

66 At the advent of cross-coupling chemistry, carbon electrophiles based on

67 report a novel copper-catalyzed imidoylative cross-coupling/cyclocondensation reaction between 2-isoc

68 Suzuki-Miyaura cross-coupling either in solution or on-resin results in

69 ased the scope of transition-metal-catalyzed cross-couplings, especially with respect to C(sp(2) )-C(

70 order to rapidly access such molecules in a cross-coupling fashion we describe olefin amine (OLA) re

71 ions at C-3, C-5, and C-6 via Suzuki-Miyaura cross-coupling followed by direct C-2 arylation using a

72 s via a palladium-catalyzed Barluenga-Valdes cross-coupling, followed by an aerobic, copper-catalyzed

73 ction sequence of Negishi and Suzuki-Miyaura cross-couplings for synthesis of combretastatin A4 is al

74 directed C-H activation and decarboxylative cross-coupling, for the enantioselective synthesis of vi

75 The SmI(2)-promoted reductive cross-coupling generated product mixtures with diastereo

76 Access to all-carbon disubstituted BCPs via cross-coupling has to date been limited to use of the BC

77 e by Ni complexes, wholly new feedstocks for cross-coupling have been realized.

78 lkyl Grignard reagents in simple ferric salt cross-couplings have been elucidated.

79 l organocatalyst to construct homoatomic C-C cross-coupling, heteroatomic O-C bond formation, and cas

80 nhanced catalytic activity in catalyzing the cross-coupling hydrogen evolution reaction, as compared

81 Although not cross-coupling in a traditional sense, we have also incl

82 A late-stage cross-coupling in concert with a modular approach to pol

83 e the tremendous utilities of metal-mediated cross-couplings in modern organic chemistry, coupling re

84 In addition to classical cross-couplings involving preformed or preactivated coup

85 this transformation and related Ni-catalyzed cross-couplings involving tertiary alkyl radicals in com

86 les for further functionalization via direct cross-coupling, iodination, or protodestannylation and i

87 o a one-pot tandem borylation/Suzuki-Miyaura cross-coupling is also demonstrated on advanced intermed

88 formation by Ullmann-type copper(I)-promoted cross-coupling is developed.

89 dithieno[3,2-b:2',3'-d]phospholes via Stille cross-coupling is reported.

90 tallate shift that occurs during conjunctive cross-coupling is shown to enable a practical and modula

91 The key to productive, selective cross-coupling is the use of a small amount of iodide or

92 hese results suggest that the Suzuki-Miyaura cross-coupling is useful for multiple conjugations of pe

93 rposes of this review, a loose definition of cross-coupling is utilized; all reactions minimally proc

94 e catalytic systems for copper-catalyzed C-N cross-couplings is described.

95 th initiating and sustaining a Ni(I)/Ni(III) cross-coupling mechanism.

96 This new Ag-mediated cross-coupling method using b-Tz is anticipated to find

97 2176 was radiolabeled via the Suzuki-Miyaura cross-coupling method.

98 Dual catalytic light-driven cross-coupling methodologies utilizing a Ni(II) salt wit

99 nctionalization of the oxidized products via cross-coupling methods demonstrates their synthetic util

100 to SET chemistry, including radical-radical cross-coupling, Minisci-type reactions, and nickel-catal

101 re prepared by a double Kosugi-Migita-Stille cross coupling of 1,4-dibromo-2,3-dinitrobenzene with an

102 e, we demonstrate copper-catalysed oxidative cross coupling of benzylic C-H bonds with alcohols to af

103 e a general and broadly applicable catalytic cross coupling of methylene ketones and secondary alcoho

104 This report details a decarboxylative cross-coupling of (hetero)aryl carboxylates with iodoare

105 visible light-mediated flow process for C-N cross-coupling of (hetero)aryl halides with a variety of

106 A simple and efficient approach of C-S cross-coupling of a wide variety of (hetero)aryl thiols

107 This work bridges a gap in the cross-coupling of aliphatic redox-active esters with ary

108 A nickel-catalyzed conjunctive cross-coupling of alkenyl carboxylic acids, aryl iodides

109 he most efficient catalyst for the selective cross-coupling of alkyl halides and allylic halides to f

110 A Negishi cross-coupling of alkylpyridinium salts and alkylzinc ha

111 is operational as part of a hetero-biradical cross-coupling of alpha-amino radicals and radicals deri

112 It is most commonly achieved via cross-coupling of alpha-haloenones, but this stepwise st

113 st example of alkyl-alkyl bond formation via cross-coupling of an alkyl amine derivative with an unac

114 Herein, we report the palladium-catalyzed cross-coupling of aryl bromides and triflates with alpha

115 A palladium-catalyzed cross-coupling of aryl chlorides/bromides with TMSCF(2)H

116 bidentate phosphine ligand that enables the cross-coupling of aryl triflates with aryl amines using

117 Herein we present a Bi-catalyzed cross-coupling of arylboronic acids with perfluoroalkyl

118 A direct dehydrogenative cross-coupling of azoles [C(sp(2))-H] with dialkyl phosp

119 luoroborates (KATs) by a palladium-catalyzed cross-coupling of boronic acids and the thioimidate KAT

120 ition has now been applied to a Cu-catalyzed cross-coupling of C(sp(3))-bromides.

121 The synthesis of aryl thioether through the cross-coupling of C-S bond is a highly attractive area o

122 report the iron-catalyzed C(sp(2))-C(sp(3)) cross-coupling of chlorobenzosulfonamides with alkyl Gri

123 were synthesized via directed metalation and cross-coupling of chrysenyl N,N-diethyl carboxamides wit

124 in conjugates that arise from the sequential cross-coupling of cysteine residues on two different pro

125 However, cross-coupling of densely functionalized substrates rema

126 Enantioselective conjunctive cross-coupling of enyne-derived boronate complexes occur

127 (II) -catalyzed enantioselective C(sp(3) )-H cross-coupling of free carboxylic acids with organoboron

128 ess the longstanding challenge of late-stage cross-coupling of functionalized alkyl fragments.

129 ion size, to the challenge of site-selective cross-coupling of multiply chlorinated arenes.

130 provide new avenues to achieve the selective cross-coupling of multiply halogenated heteroarenes.

131 The Pd(OAc)(2) catalyzed cross-coupling of N-substituted phthalimides with aryl h

132 a Co(II)[salen]-catalyzed aerobic oxidative cross-coupling of phenols in a recyclable 1,1,1,3,3,3-he

133 d bite angle was presumably important in the cross-coupling of sterically hindered bulky PAHs.

134 ) species) is critical for effective radical cross-coupling of tertiary alkyl radicals.

135 borylation can be followed by Suzuki-Miyaura cross-coupling of the C-borylated indoles in an overall

136 The dyes were prepared by the Suzuki cross-coupling of the electron-poor fluorescein ditrifla

137 Cross-coupling of the putative alpha-amino radical with

138 Herein, we describe a mild, copper-catalyzed cross-coupling of these fluoroalkyl nucleophiles with ar

139 e also demonstrate conditions for the Hiyama cross-coupling of these products to prepare geometricall

140 yrone, and studies related to site-selective cross-coupling of this polyhalogenated heterocycle are d

141 unprecedented ruthenium(II) catalyzed direct cross-coupling of two different secondary alcohols to be

142 matic catalysis(6) has not been used for the cross-coupling of two molecules.

143 An effective nickel-catalyzed cross-coupling of Umpolung carbonyls and alkyl halides w

144 mpared to aryl or alkenyl electrophiles, the cross-coupling of unactivated alkyl electrophiles contai

145 g of Pd(II) complexes enables Suzuki-Miyaura cross-coupling of unactivated Csp(3) boronic acids with

146 lex alkyl boronic esters through conjunctive cross-coupling of vinyl boronic esters with carboxylic a

147 Ir-OTf effectively catalyzed dehydrogenative cross-couplings of heteroarenes with ethers, amines, and

148 inal functionalization at position 6 through cross-couplings or nucleophilic substitutions.

149 on was predicated on strategic design of the cross-coupling partners (phenol esters and silyl amines)

150 preparation of monomers for metal-catalyzed cross-coupling polymerization is demonstrated.

151 This analysis reveals that cross-coupling proceeds by a Ni(0/II) cycle with a Ni(II

152 The current cross-coupling proceeds with the generation of an alkoxy

153 l electrophiles, and ranges from traditional cross-coupling processes to alternative nucleophilic rea

154 to be of critical importance in Sonogashira cross-coupling processes.

155 lectrophiles and nucleophiles leading to new cross-coupling processes.

156 rectly to the corresponding tertiary radical cross-coupling products via an outer-sphere reductive el

157 ting the performance of a photocatalytic C-N cross-coupling reaction across multiple reactor sizes an

158 detailed mechanistic study of the aziridine cross-coupling reaction and the role of EDO ligands in f

159 s been accomplished using the Suzuki-Miyaura cross-coupling reaction at or near physiological tempera

160 The Buchwald-Hartwig cross-coupling reaction between 4-methylumbelliferone-de

161 Capitalizing on the Pd-catalyzed Suzuki cross-coupling reaction between a tris-triflate borazine

162 The selective FeCl(3)-catalyzed oxidative cross-coupling reaction between phenols and primary, sec

163 Cross-coupling reaction between two C-H bonds has become

164 A highly chemoselective phenol cross-coupling reaction catalyzed by a Cr-salen catalyst

165 This reductive cross-coupling reaction displays a fairly unusual anti s

166 chnology, high yield and reproducible Suzuki cross-coupling reaction for one of our key intermediates

167 ts into an iridium/nickel photocatalytic C-O cross-coupling reaction from time-resolved spectroscopic

168 rtant factors affecting the Buchwald-Hartwig cross-coupling reaction have been optimized.

169 The Pd-catalyzed cross-coupling reaction of 1-acetyl-2-methyl-3H-pyrrolo[

170 oCl(2)/IAd.HBF(4) enables the Suzuki-Miyaura cross-coupling reaction of a broad range of aryl triflat

171 a quaternary center occurred through a rare cross-coupling reaction of a tertiary organometallic com

172 An efficient palladium-free Stille cross-coupling reaction of allylic bromides and function

173 xidative addition is the key step during the cross-coupling reaction of aryl halides has led to the d

174 Almost two decades passed before the first cross-coupling reaction of heteroatom-based electrophile

175 on condition screening for a radical-radical cross-coupling reaction on micro-fabricated interdigitat

176 Their reactivity in a Negishi cross-coupling reaction was tested.

177 through a palladium-catalyzed Suzuki-Miyaura cross-coupling reaction with arylboronic acids in good y

178 Pd(0)-catalyzed carbopalladation followed by cross-coupling reaction with boronic acids.

179 oducing biocatalysts with a Buchwald-Hartwig cross-coupling reaction, affording a variety of alpha-ch

180 c transformations such as the Suzuki-Miyaura cross-coupling reaction, C-H bond activation, dehydrogen

181 terocycles participate in the Suzuki-Miyaura cross-coupling reaction, enabling entry into diverse bis

182 Starting with a Sonogashira cross-coupling reaction, enynol (10) was prepared.

183 e efficient synthetic tool, Buchwald-Hartwig cross-coupling reaction, for the functionalization of 1,

184 e, purine, azaindole) can be utilized in the cross-coupling reaction, including those substituted wit

185 eterogeneous catalyst for the Suzuki-Miyaura cross-coupling reaction, outperforming its amorphous cou

186 nistic underpinnings to a photocatalytic C-N cross-coupling reaction.

187 s of the palladium-catalyzed decarboxylative cross-coupling reaction.

188 nces the quantum yield and efficiency of the cross-coupling reaction.

189 nd (e.g., BIDIME) was reported in the Suzuki cross-coupling reaction.

190 lysis to predict the regioselectivity of the cross-coupling reaction.

191 hexagons, by means of a palladium-catalyzed cross-coupling reaction.

192 e MCF-7 lineage as an efficient catalyst for cross-coupling reaction.

193 ioethers via a Ni-catalyzed stereoconvergent cross-coupling reaction.

194 alation step required for the Suzuki-Miyaura cross-coupling reaction.

195 ic alkylation expands the synthetic scope of cross-coupling reactions and can be further extended to

196 t into the overall mechanism of Ni-catalyzed cross-coupling reactions and offers a basis for differen

197 The heteroarylsilane products undergo cross-coupling reactions and substitution reactions with

198 Transition metal-catalysed cross-coupling reactions are widely used for constructio

199 Its nucleophilic substitutions or cross-coupling reactions at position 8 and deprotection

200 Suzuki-Miyaura cross-coupling reactions between a variety of alkyl hali

201 atalyst capable of promoting carbon-nitrogen cross-coupling reactions between a variety of primary am

202 ingle kinetically relevant step in different cross-coupling reactions catalyzed by sub-nanometer Pt o

203 Such stereospecific cross-coupling reactions constitute a powerful synthetic

204 in monomers that participate in coupling and cross-coupling reactions during lignification in Norway

205 Cross-coupling reactions enable rapid, convergent synthe

206 Cross-coupling reactions for carbon-carbon and carbon-he

207 and phenol derivatives as electrophiles for cross-coupling reactions has numerous advantages over co

208 Asymmetric Ni-catalyzed cross-coupling reactions have become a very attractive t

209 Examples of stereospecific, Pd-catalysed cross-coupling reactions have been reported for isolable

210 Transition-metal-catalysed cross-coupling reactions have been widely used for their

211 Advances in Pd-catalysed cross-coupling reactions have facilitated the developmen

212 Palladium-catalyzed cross-coupling reactions have transformed the exploratio

213 catalysts opens new avenues in the design of cross-coupling reactions in organic synthesis.

214 Advances in metal-catalyzed cross-coupling reactions in the early 2000s brought a hi

215 We report diverse C-N cross-coupling reactions of aryl thianthrenium salts tha

216 synthesis involved site-selective palladium cross-coupling reactions of chloropyrimidines with trior

217 enamides that are useful building blocks for cross-coupling reactions or heterocyclic chemistry.

218 Employment of sulfoxides as electrophiles in cross-coupling reactions remains underexplored.

219 in photoredox Ni-catalyzed carbon-heteroatom cross-coupling reactions through a strategy that allows

220 An additional protocol that allows Suzuki cross-coupling reactions to be performed on bromo-substi

221 the most reactive precursors for N-C(O) bond cross-coupling reactions to date, wherein the reactivity

222 ively proposed as a key step in Ni-catalyzed cross-coupling reactions to generate radical intermediat

223 ks late-stage diversification through Suzuki cross-coupling reactions to give mono-, di-, and trisubs

224 ant (Hantzsch ester), whereas most reductive cross-coupling reactions use stoichiometric metals.

225 s well as chemodivergent palladium catalyzed cross-coupling reactions using boronic acids are applied

226 In most cases, cross-coupling reactions using OACs proceed under milder

227 lic coupling partners in palladium-catalyzed cross-coupling reactions with (hetero)aryl halides.

228 roved to be more effective in catalyzing C-N cross-coupling reactions with a diverse selection of ami

229 arries mechanistically distinct, traditional cross-coupling reactions with C-H functionalization usin

230 les broad compatibility of carbon-heteroatom cross-coupling reactions with sensitive substrates and f

231 exert electric-field effects on the rate of cross-coupling reactions, and their cocatalytic effects

232 Transition-metal-catalysed cross-coupling reactions, particularly those mediated by

233 Reactions covered include common cross-coupling reactions, such as Suzuki, Heck, Kumada,

234 ces in transition-metal-catalyzed C(sp(3))-C cross-coupling reactions, there remain challenging bond

235 proposed in numerous Ni-catalyzed reductive cross-coupling reactions-has been subject to speculation

236 nds as substrates for Suzuki and Sonogashira cross-coupling reactions.

237 ution and through transition-metal-catalyzed cross-coupling reactions.

238 visible light photoredox catalysts for aryl cross-coupling reactions.

239 e precursors prepared by palladium-catalyzed cross-coupling reactions.

240 s the range of reagents available for N-C(O) cross-coupling reactions.

241 nvolving two consecutive palladium-catalyzed cross-coupling reactions.

242 e scope of Ni-catalyzed reductive asymmetric cross-coupling reactions.

243 (CMPs) synthesized by Buchwald-Hartwig (BH) cross-coupling reactions.

244 nd alkynyl groups, in excellent yields using cross-coupling reactions.

245 ovel approach to facilitate nickel-catalyzed cross-coupling reactions.

246 anding catalytic activity for Suzuki-Miyaura cross-coupling reactions.

247 are challenging targets for metal-catalyzed cross-coupling reactions.

248 limitations of iron-catalyzed Kumada-Corriu cross-coupling reactions.

249 echanisms in the growing class of HAT alkene cross-coupling reactions.

250 ituent at the 3-position and Pd(0)-catalyzed cross-coupling reactions.

251 ng complementary choices for further various cross-coupling reactions.

252 t the stereochemical outcome of Pd-catalysed cross-coupling reactions.

253 nucleophiles in stereospecific, Pd-catalysed cross-coupling reactions.

254 their impact on the stereochemical course of cross-coupling reactions.

255 g, Suzuki-Miyaura, and metallophotoredox C-N cross-coupling reactions.

256 onstrated by applying it to literature known cross-coupling reactions.

257 bility and poor reactivity in Suzuki-Miyaura cross-coupling reactions.

258 made, controlling stereochemistry in Csp(3) cross-coupling remains challenging.

259 Allylation and conjunctive cross-coupling represent two useful, yet largely distinc

260 late-stage diversification by Suzuki-Miyaura cross-coupling (SMC), resulting in new-to-nature biaryl

261 ally requires an additional high temperature cross-coupling step following the nanoribbon formation t

262 op synthetic access to this family, a Stille cross-coupling strategy is used to construct the bis-imi

263 Herein we report a transition-metal-free cross-coupling strategy utilizing aryl(heteroaryl) methy

264 ecent developments in several types of alkyl cross-couplings that are accessible exclusively through

265 ons of transition metal/photoredox-catalysed cross-coupling, thermal/photosensitized radical chain CH

266 controlled aryl-hydroxyl Friedel-Crafts-type cross-coupling to construct the tetra- or pentacyclic br

267 izing gamma-selective allylic Suzuki-Miyaura cross-coupling to generate 1,1-diarylalkanes.

268 lops a practical solution for site-selective cross-coupling to generate complex, highly substituted a

269 adium-catalyzed intramolecular C-H/C-Br bond cross-coupling to produce a variety of dibenzosuberones

270 Transition-metal-catalyzed cross-couplings to construct C-C, C-O, and C-N bonds hav

271 chiral alcohols via a one-pot Suzuki-Miyaura cross-coupling/transfer-hydrogenation process.

272 on was probed, yielding insight that enabled cross-coupling trimerizations.

273 The fundamental reaction steps of such cross-couplings typically include oxidative addition, tr

274 otocatalysis and nickel catalysis can effect cross-coupling under mild conditions, but little is know

275 While AA ligated C-N cross-couplings under Pd and Ni catalysis were minor or

276 n precursors were prepared by two sequential cross couplings using 4-iodo-2,3-dinitrophenyl trifluoro

277 e rational development of new stereospecific cross-coupling variants.

278 or tandem Pd-catalyzed carbonylation and C-C cross-coupling via C-H activation was designed.

279 The decarboxylative conjunctive cross-coupling was also applied to the synthesis of sedu

280 The mechanistic insight of cross-coupling was obtained by deuterium kinetic isotope

281 f the photonic flux within each reactor, the cross-coupling was scaled successfully from the milligra

282 ineffective, the AA ligated Cu-catalyzed C-N cross-couplings were promising particularly with the use

283 ipates in the subsequent palladium-catalyzed cross-coupling, which furnishes benzylic alkyl boronate

284 s and solutions for the key Pd-catalyzed C-N cross-coupling will also be discussed in detail.

285 ough sequential intermolecular reductive C-N cross coupling with boronic acids, followed by intramole

286 lyst activates the alkyl iodide and promotes cross coupling with the alkenyl copper intermediate.

287 ntional Cu(I) salts used in Liebeskind-Srogl cross-coupling with a Ag(2)O mediator resulted in higher

288 homochiral Glaser coupling and heterochiral cross-coupling with a Bergman cyclization step have been

289 lectrophiles in nickel-catalyzed conjunctive cross-coupling with a non-conjugated alkene and dimethyl

290 shielding enables perfectly stereoretentive cross-coupling with a range of unactivated secondary Csp

291 entanes (iodo-BCPs) by direct iron-catalyzed cross-coupling with aryl and heteroaryl Grignard reagent

292 of halogenated analogues and Suzuki-Miyaura cross-coupling with aryl boronic acids allowed the synth

293 Cross-coupling with arylboronic acids and a new reagent,

294 arbon centers via Ni-catalyzed Csp(3)-Csp(3) cross-coupling with aziridines.

295 This strategy also enables cross-coupling with Boc-protected aziridines.

296 the first time, the combination of modern Pd-cross-coupling with Cr-catalyzed reduction allows for ra

297 rophiles not only limited to the traditional cross-coupling with Grignard reagents, but also includin

298 The second was reductive cross-coupling with methyl- or phenylglyoxal promoted by

299 resence of NMP, a key additive for effective cross-coupling with simple ferric salts and beta-hydroge

300 d their higher homologues is demonstrated by cross-coupling with unactivated alkyl bromides, generati