ライフサイエンスコーパス: cross-priming

1 cross-tolerance) or induce immune responses (cross-priming).

2 hen presented to the MHC class II and as -I (cross-priming).

3 in relevant tissues; and facilitated antigen cross-priming.

4 been widely reported to play a major role in cross-priming.

5 to the MHC class I pathway and CD8(+) T cell cross-priming.

6 ular antigens presented by direct priming or cross-priming.

7 ability to induce TS-specific CD8(+) T cell cross-priming.

8 implicated in Ag presentation by MHC and in cross-priming.

9 ht explain the hyperthermia-induced enhanced cross-priming.

10 ed cells induced by either direct priming or cross-priming.

11 teomics to understanding Ag presentation and cross-priming.

12 r to cDCs as a mechanism for pDCs to achieve cross-priming.

13 cells, isotype switching, and stimulation of cross-priming.

14 ing, indicating that they were indeed due to cross-priming.

15 endritic cells in inducing CD8 responses via cross-priming.

16 o CD8(+) T cells in a process referred to as cross-priming.

17 enting capacity of dendritic cells (DCs) and cross-priming.

18 mma and probably by a mechanism unrelated to cross-priming.

19 and BALB/c-specific CTLs to reveal classical cross-priming.

20 entation to CTL in vivo, a phenomenon termed cross-priming.

21 sults support the TAP-dependent mechanism of cross-priming.

22 th Flt3L to promote anti-tumor CD8(+) T cell cross-priming.

23 rect cytotoxic effects and indirect-mediated cross-priming.

24 ocess of cognate T cell activation is termed cross-priming.

25 by dendritic cells and enhance CD8(+) T cell cross-priming.

26 pDCexo-mediated antigen transfer to cDCs for cross-priming.

27 (+) T cells through a process called antigen cross-priming.

28 g cells was not sufficient for CD8(+) T cell cross-priming.

29 alization was not observed in the absence of cross-priming.

30 of tumor Ag-specific CD8(+) T cells through cross-priming.

31 how DNGR-1 couples dead cell recognition to cross-priming.

32 wild-type TAg is due in part to inefficient cross-priming.

33 With regard to cross-priming, a better understanding of the nature of t

34 lications for the biological significance of cross-priming, a process thought by some to be important

35 Instead, the cells cross-priming ability correlated with their steady-state

36 The enhanced cross-priming ability of TIDCs after RT was dependent on

37 It remains unknown whether cross-priming ability translates into any clinical advan

38 neither T cell priming by endogenous Ags nor cross-priming ability was substantially affected in acti

39 ss in hyperlipidemic mice profoundly reduces cross-priming ability, nevertheless it does not influenc

40 , and not the CD8(-), DC subset demonstrates cross-priming ability.

41 n subcellular fractionation experiments, the cross-priming activity colocalized with antigenic protei

42 of the immunogenic ovalbumin peptide, their cross-priming activity differed markedly.

43 of CD8 CTL by several million-fold over the cross-priming activity of unchaperoned protein alone.

44 n from these cell fractions eliminated their cross-priming activity.

45 ntial to result in enhanced antitumor T-cell cross-priming against a broad array of naturally process

46 germinal center formation and CD8(+) T cell cross-priming against an exogenous model Ag, OVA.

47 ic dsRNA leads to a striking increase in CTL cross-priming against cell-associated antigens, which is

48 tivated pDCs induced robust, spontaneous CTL cross-priming against multiple B16 tumor antigens, leadi

49 No significant decline in cross-priming against OVA was measured when either TNF o

50 This demonstration of cross-priming against shared tumor antigens builds the b

51 onor-derived cells, most probably donor APCs cross-priming alloreactive CD8 cells.

52 od for detecting PEDV was developed based on cross-priming amplification and nucleic acid test strip(

53 he N gene sequence of PEDV were used for the cross-priming amplification.

54 CD8 T cell cross-priming, an established mechanism of protective an

55 poptosis and thus may interfere with optimal cross-priming and action of CD8(+) T cells (see the rela

56 ptimal priming of CD8+ T cells requires both cross-priming and cross-dressing.

57 + myeloid-derived DCs were required for both cross-priming and cross-tolerance.

58 hway corresponds to the in vivo phenomena of cross-priming and cross-tolerance.

59 dendritic cells (DCs) that are conducive to cross-priming and DC cross-talk.

60 nic vaccinia virus determinants generated by cross-priming and direct priming are not completely over

61 Furthermore, they suggest that 1) both cross-priming and direct priming contribute significantl

62 Cross-priming and direct priming differ in the source of

63 cells has been attributed to two mechanisms: cross-priming and direct priming.

64 There is reasonable evidence that both cross-priming and direct transfection of antigen-present

65 that pDC-targeted vaccination led to strong cross-priming and durable CD8 T cell immunity.

66 over, host ANGPTL2 facilitates CD8(+) T-cell cross-priming and enhances anti-tumor immune responses.

67 ollectrin expression leads to the diminished cross-priming and expansion of cytolytic antiviral CD8(+

68 ic impact, but significantly enhanced T cell cross-priming and lesional infiltration of tumor-reactiv

69 alpha, CpG, and LPS stimulation, and also in cross-priming and licensing cytotoxic T cell killers in

70 intrinsic role for XBP1 in DC for effective cross-priming and orchestration of Batf3(+) DC-pDC inter

71 h source of immunogens for anti-tumor T cell cross-priming and sensitizing cancer cells to interventi

72 tingly, ProIFN-treated mice show enhanced DC cross-priming and significant increased CD8(+) infiltrat

73 ly injected DCs that may concertedly promote cross-priming and the accelerated immune-mediated reject

74 These results indicate that control of cross-priming and thereby immunogenicity of primary ster

75 man DC subsets that can be exploited for CTL cross-priming and tumor therapy.

76 presenting cells, indirect presentation (or cross-priming), and chaperoning of peptides during antig

77 usceptible to NK cell-mediated inhibition of cross-priming, and cross-linking of DR5 receptor led to

78 stituted the major skin DC subset capable of cross-priming antigen-specific CD8+ T cells ex vivo.

79 re separable from the cell's main sources of cross-priming antigen.

80 ramatic example is the in vivo phenomenon of cross-priming: antigens from donor cells are acquired by

81 In conclusion, the efficiency of cross-priming appears to be poor in most donors and is d

82 Clec9a(-/-) mice deficient in DC cross-priming are protected from persistent immune-media

83 ction, together with dendritic cell-mediated cross-priming, are the key elements.

84 We present additional findings that point to cross-priming as the likely mechanism for these protein-

85 oteasomal degradation within beta-cells, the cross-priming, autoimmune-initiating potential of this a

86 sively loaded peptide or against tumor Ag by cross-priming autologous CD8(+) T cells.

87 Interestingly, this cross-priming bias was lost following MN immunization wi

88 ism for beta-catenin-dependent inhibition of cross-priming, but also uncovered an unexpected positive

89 ts bacterial replication and promotes T cell cross-priming by antigen-presenting cells.

90 In cancer mouse models, CD8(+) T cell cross-priming by cDC1s is crucial for the efficacy of mo

91 Exogenous IFN-? treatment rescued the cross-priming by cGAS or STING-deficient DCs.

92 n induced by this vaccine is consistent with cross-priming by dendritic cells.

93 These results show that efficient cross-priming by migratory lung DCs is coupled to the ac

94 Gp96 also acts as adjuvant for cross-priming by unchaperoned proteins, but in this capa

95 l responses by Cantor and Boyse in 1974 and "cross-priming" by Bevan in 1976.

96 lls, others, such as those mediated through 'cross-priming' by host antigen-presenting cells, are dep

97 However, "cross-priming" can also occur, whereby peptides derived

98 f3(-/-) chimeras had a 75% reduction in OT-I cross-priming capacity in vivo.

99 of ionizing radiation (IR) by increasing the cross-priming capacity of DCs across multiple murine can

100 /interferon I pathway, resulting in enhanced cross-priming capacity of DCs and tumor-specific CD8(+)

101 RT drastically enhances the cross-priming capacity of tumor-infiltrating dendritic c

102 rred MHC class I/peptide complexes to confer cross-priming capacity to MHC class I-deficient lymph no

103 I processing pathway, allowing long-lasting, cross-priming capacity.

104 nferred antigen-naive cDCs the capability of cross-priming CD8 T cells by transferring antigens to cD

105 that CD8alpha(+) DCs play a critical role in cross-priming CD8(+) T cell responses to circulating pro

106 the roles of different murine DC subsets in cross-priming CD8(+) T cells can change with the nature

107 In this article, we show that cross-priming CD8alpha(+) and CD103(+) DC subsets expres

108 hus, classic MHC class I Ag presentation and cross-priming contribute differentially to the induction

109 kDa heat shock protein (HSP70), and enhanced cross-priming could be reproduced by overexpression of H

110 to the ER in a TAP-independent fashion, but cross-priming could not be demonstrated.

111 Activation of cytotoxic CD8(+) T cells by cross-priming DC contributes to exacerbation of postisch

112 Cross-priming DC have the ability to activate both CD4(+

113 This study investigates a role for cross-priming DC in post-myocardial infarction immunopat

114 A diverse DC population, including cross-priming DC, is present in the heart and activated

115 that recruiting and activating intratumoral, cross-priming DCs is achievable and critical to anti-tum

116 ivating Fc receptors for IgG (FcgammaRs) and cross-priming DCs.

117 These results suggest that when cross-priming dendritic cells present class I/Ag and cos

118 "Cross-priming" describes the activation of naive CD8+ T

119 together, these findings suggest either that cross-priming dominates over direct CD8 T cell priming i

120 CD8 responses to whole-protein Ags in poorly cross-priming donors.

121 feedback loop by which NKT cells control CTL cross-priming downstream of DC maturation.

122 to overcome CD40L blockade of CD8(+) T cell cross-priming during bacterial infection.

123 rotic and apoptotic death can enhance T cell cross-priming during infection, mice that lack these ext

124 Here we describe a mechanism that promotes cross-priming during viral infections.

125 s has implications for the proposed role of "cross-priming" during virus infection and for the utilit

126 icipate critically in processing antigen for cross-priming, even if they do not present that antigen

127 In cross-priming, exogenous Ag is acquired by professional

128 DEC-HIV Gag p24 showed better cross-priming for CD8(+) T cells, whereas the avidity of

129 ild type and Clec9a-depleted mice lacking DC cross-priming function.

130 fic CD8(+) T cell responses, through in vivo cross-priming, has remained unclear.

131 e assessed the contribution of direct versus cross priming in mouse CMV (MCMV) infection using recomb

132 This led to cross priming in vitro and in vivo and to expansion of l

133 derscoring the significance of tumor antigen cross-priming in contexts of immunogenic cell death.

134 Our work thus underscores the importance of cross-priming in immunity and indicates that antigenicit

135 DNGR-1 regulated cross-priming in non-infectious settings such as immuniz

136 accelerated CD8 T-cell memory after in vivo cross-priming in the absence of adjuvant is generalizabl

137 elative importance of direct presentation vs cross-priming in the induction of CTL responses to virus

138 al type one dendritic cells [cDC1]), whereas cross-priming in the presence of inflammasome activation

139 ere internalized by CD8 T lymphocytes during cross-priming in vitro and in vivo, resulting in marked

140 o not significantly contribute to CD8 T cell cross-priming in vitro.

141 required conventional DCs (cDCs) to achieve cross-priming in vivo by transferring antigens to cDCs.

142 NY-ESO-1-specific CD8(+) T cell responses by cross-priming in vivo was associated with the induction

143 fraction of naive T cells triggered through cross-priming in vivo, we show that immunization with TA

144 ion of IL-12p40, a cytokine known to promote cross-priming in vivo.

145 cDC1s played a critical role in pDC-mediated cross-priming independent of their function in antigen p

146 reticulum (ER) critically needed for T cell cross-priming induced by a DC-targeted vaccine.

147 ype I IFN and IL-12 as critical mediators of cross-priming induced by a TLR7 agonist-antigen conjugat

148 This enhanced cross-priming is accompanied by a higher density of OVA(

149 fection of these cells, which indicates that cross-priming is an essential component of the immune re

150 We show here that cross-priming is based on the transfer of proteasome sub

151 Cross-priming is essential for generating cytotoxic T ly

152 Cross-priming is essential for the induction of CD8(+) T

153 The OVA-Le(X)-induced enhancement of T cell cross-priming is MGL1-dependent as shown by reduced CD8(

154 Cross-priming is the process in which Ag-presenting dend

155 cy for these 2 cytokines during TLR7-induced cross-priming is the result of their divergent effects o

156 ) or Ags acquired from other infected cells (cross-priming) is a critical topic in basic and applied

157 + T cell response during HSV-1 infection, or cross-priming, is highly GILT-dependent, as is initiatio

158 Although IL-12 was indispensable during cross-priming, it did not regulate DC function.

159 sts as to whether indirect presentation (the cross-priming mechanism) can contribute to effective in

160 ock protein 70-linked peptide chaperone in a cross-priming method of immune induction by DNA vaccinat

161 oss-presentation that is highly efficient in cross-priming murine CD8 T cells in vivo.

162 rmal lymphoid organs, they were defective in cross-priming naive CD8(+) T cells following vaccination

163 itic cells (DCs) abrogates FcgammaR-mediated cross priming of diabetogenic T cells in RIP-mOVA mice,

164 ese DC subsets are regarded as superior for (cross-) priming of naive T cells, controversies still re

165 from skin/tumor draining lymph nodes and the cross-priming of Ag-specific CD8(+) T cell responses ass

166 ng multiple Ag systems, we demonstrated that cross-priming of Ag-specific CD8+ T cells was inefficien

167 t B lymphocytes, in addition to DCs, mediate cross-priming of Ag-specific T cells.

168 ligand in dying infected cells and mediated cross-priming of anti-VACV CD8(+) T cells.

169 The requirement for CD4(+) Th cells in the cross-priming of antitumor CTL is well accepted in tumor

170 ptor 9 (TLR9), and conventional DCs promotes cross-priming of capsid-specific CD8(+) T cells.

171 d their receptors [corrected] CD28/CTLA-4 in cross-priming of CD4-dependent CTL in vivo.

172 increased CD28 signaling and a commitment to cross-priming of CD4-dependent CTL.

173 eroned peptides enhance the efficiency of Ag cross-priming of CD8 CTL by several million-fold over th

174 Gp96-driven MHC I cross-priming of CD8 CTL in the absence of lymph nodes p

175 MHC class I-mediated cross-priming of CD8 T cells by APCs is critical for CTL

176 presentation by dendritic cells in vitro and cross-priming of CD8 T cells in vivo.

177 Gp96-mediated cross-priming of CD8 T cells requires B7.1/2 costimulati

178 though it is known that TLR3 is required for cross-priming of CD8 T cells specific for viral Ags, the

179 red cross-presentation ex vivo and defective cross-priming of CD8(+) T cell responses in vivo.

180 ortantly, Nfil3(-/-) mice exhibited impaired cross-priming of CD8(+) T cells against cell-associated

181 Cross-priming of CD8(+) T cells by DCs is required for i

182 Cross-priming of CD8(+) T cells by DCs treated with poly

183 t activation of beta-catenin in DCs inhibits cross-priming of CD8(+) T cells by up-regulating mTOR-de

184 Cross-priming of CD8(+) T cells failed to occur in mice

185 ross-presentation of tumour antigens and the cross-priming of CD8(+) T cells in vivo.

186 Antigen cross-priming of CD8(+) T cells is a critical process ne

187 alpha-TEA to stimulate autophagy and enhance cross-priming of CD8(+) T cells might be exploited as an

188 In the absence of inflammasome activation, cross-priming of CD8(+) T cells required Batf3(+) dendri

189 f cell-associated Ag and subsequently in the cross-priming of CD8(+) T cells than were their young co

190 Triggering TLR7 enhances cross-priming of CD8(+) T cells, which requires cross-pr

191 ndritic cells (DCs) directly correlates with cross-priming of CD8(+) T cells.

192 ptides can be complexed with class I MHC for cross-priming of CD8(+) T cells.

193 Ag by dendritic cells as well as for in vivo cross-priming of CD8(+) T cells.

194 r regulatory molecules and promote antigenic cross-priming of CD8(+) T cells.

195 hich drives type I interferon production for cross-priming of CD8(+) T cells.

196 endritic cells activation, which induces the cross-priming of CD8(+) T cells.

197 d Th1 skewing of CD4(+) T cells and enhanced cross-priming of CD8(+) T cells.

198 mediating cross-presentation, as well as the cross-priming of CD8(+) T cells.

199 Ag peptide complexes, followed by attenuated cross-priming of CD8(+) T cells.

200 A or beta-galactosidase) and TRiC results in cross-priming of CD8(+) T lymphocytes specific for K(b)/

201 oss-presentation is further shown to control cross-priming of CD8(+) T-cell responses in vivo such th

202 SLiPs is an excellent source of antigen for cross-priming of CD8(+) T-cells that recognize shared tu

203 Cross-priming of CD8+ T cells and generation of effector

204 m operating in Ag donor cells that regulates cross-priming of CD8+ T cells during primary sterile nec

205 mmune protection against tumors requires the cross-priming of CD8+ T cells under conditions that requ

206 Cross-priming of cognate CD8 cells can result in either

207 This cross-priming of CTL was dependent on both CD4+ and CD8+

208 Thus, TLR3 may have evolved to permit cross-priming of CTLs against viruses that do not direct

209 tly stimulates STING signaling and increases cross-priming of dendritic cells after anti-CD47 treatme

210 tocompatibility antigens (HA) as revealed by cross-priming of H2 heterozygous recipients effectively

211 iated cell killing very efficiently promotes cross-priming of immature dendritic cells with a model t

212 uccess, probably in part due to insufficient cross-priming of myeloma antigens.

213 grees C before killing are more efficient in cross-priming of naive CD8(+) T cells than DCs loaded wi

214 T cells to provide the "help" necessary for cross-priming of naive CTL, it is unclear how this makes

215 L. monocytogenes and OVA-loaded splenocytes, cross-priming of OVA-specific naive CD8(+) T cells occur

216 ndicate a possible role for NIK in mediating cross-priming of soluble Ag.

217 , our data provide clear evidence of in vivo cross-priming of specific cytotoxic T lymphocytes by a r

218 depend on dendritic cell but not macrophage cross-priming of T cell responses.

219 Using systems where direct and cross-priming of T cells can be distinguished revealed t

220 ation of dendritic cells as well as enhances cross-priming of T cells to tumor-derived antigens and t

221 nd even necessary for cross-presentation and cross-priming of T cells.

222 Thus, cross-priming of therapeutic CD8(+) T cells by a tumor v

223 we show that NK cells can limit spontaneous cross-priming of tumor Ag-specific CD8(+) T cells, leadi

224 NK cells inhibit DC cross-priming of tumor Ags in vitro, but not direct pres

225 e critical in initiating immune responses by cross-priming of tumor Ags to T cells.

226 ut not perforin, were not able to inhibit DC cross-priming of tumor Ags.

227 cal features favoring cDC1 for the efficient cross-priming of tumor antigens.

228 to the tumor draining lymph node to initiate cross-priming of tumor-reactive cytotoxic CD8(+) T cells

229 rect presentation occurs, and find efficient cross-priming of tumor-specific CD8+ T cells in the comp

230 Dendritic cells (DCs) mediate cross-priming of tumor-specific T cells by acquiring tum

231 of the Toll-like receptor TLR3 in promoting cross-priming of viral antigens provide new insights int

232 esults in a cytotoxic T cell (CTL) response (cross-priming) or in CD8+ T cell inactivation (cross-tol

233 iming are not completely overlapping, and 3) cross-priming overrides the effects of cis-acting viral

234 DCIR-mediated cross-presentation as well as cross-priming, particularly when combined with a CD40 si

235 ll cytoplasm, suggesting that an alternative cross-priming pathway might be necessary for class I pre

236 n-infected cells that take up Ag through the cross-priming pathway.

237 of exogenous antigen by immature DCs in this cross-priming pathway.

238 esults show that DC might be involved in the cross-priming phenomenon.

239 MV promoter-driven vaccines, indicating that cross-priming plays a major role in the generation of im

240 at treatment of tumor cells permits enhanced cross-priming, possibly via up-regulation of both HSPs a

241 atient-derived PBMC, we studied the in vitro cross-priming potential of Melan-A 16-40 LP bearing the

242 eover, IFNalpha endowed LSECs with efficient cross-priming potential that, along with the early intra

243 Such a cross-priming process may represent a principal mechanis

244 ase tumor antigen for cross-presentation and cross-priming, release cancer-suppressive cytokines and

245 The molecular mechanism(s) underlying cross-priming remain poorly defined and highly controver

246 Instead, robust cross-priming required receptor-interacting protein kina

247 primed by donor CD11c(+) cells, and optimal cross-priming required that they are stimulated by both

248 We demonstrate that TLR7-driven cross-priming requires both Type I IFN and IL-12.

249 Cross-priming studies also suggested that a conserved T-

250 In vitro cross-priming studies revealed that few strategic nucleo

251 Cross-priming, the activation of naive CD8+ T cells by d

252 T cells in vivo, with particular emphasis on cross-priming, the presentation of protein antigens acqu

253 adicating immunity indirectly as a result of cross-priming through B7-expressing host APCs.

254 n pathway and Batf3 dendritic cell-dependent cross-priming to bridge innate and adaptive immune respo

255 capacity translated into a greater degree of cross-priming to CD8(+) T cells (T(CD8)(+)) and more-rob

256 dendritic-cell subset involved in regulating cross-priming to cell-associated antigens.

257 bsolute requirement for a functional TAP for cross-priming to occur in vivo.

258 tance of specific antibody induction for the cross-priming to occur, and support the use of this type

259 Cross-priming to the immune-dominant determinant HYUtyp

260 ole, or what is the relative contribution of cross-priming to the induction of acquired immunity afte

261 pDCs, cDC1s but not cDC2s were required for cross-priming upon pDC-targeted vaccination, suggesting

262 elicit a T(CD8+) response, probably due to a cross-priming via pAPCs.

263 The enhanced cross-priming was demonstrated by several parameters: 1)

264 This T cell cross-priming was mediated by conventional DCs (cDCs) an

265 Cross-priming was surprisingly efficient, whether antige

266 ated signals that influence helper-dependent cross-priming, while focusing on the source and cellular

267 On a molar basis, cross-priming with 3-mer-extended peptide is 20-fold mor

268 cts, inducing tumor-associated antigen (TAA) cross-priming with antitumor CD8+ T cell elicitation and

269 Here, we demonstrate that in vivo cross-priming with cell-associated antigens or antigen-c

270 We compared the efficiency of cross-priming with exogenous proteins to use of peptide

271 Ps deliver sufficient chaperoned antigen for cross-priming within the quantitative limits set by nasc

272 The process of cross-priming would be most economical and efficient if