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1 epair excises toxic replication-blocking DNA crosslinks.
2 ompared with the repair of cisplatin-induced crosslinks.
3 ential step in the repair of DNA interstrand crosslinks.
4 ation that make it selective for DNA-protein crosslinks.
5 se polypeptide chains are linked by covalent crosslinks.
6 PAGE bands did not show any evidence of zein crosslinking.
7 bers is prepared by dripping, diffusion, and crosslinking.
8 ses thiol-vinyl sulfone Michael addition for crosslinking.
9 oxacillin and showed increased peptidoglycan crosslinking.
10 oderate to minimal inhibition of collagen IV crosslinking.
11 odes a lysyl oxidase that catalyzes collagen crosslinking.
12 cting tracks form through oxidative tyrosine crosslinking.
13 PAI-1), and fibrin formation, but not fibrin crosslinking.
14 gnitude larger than the conventional thermal crosslinking.
15 networks through rapid binding and filament crosslinking.
16 en hydrogels through covalent intermolecular crosslinking.
17 ECM), (3) preserved collagen composition and crosslinking, (4) a decellularized material milieu with
18 viruses and irradiated with 365 nm light to crosslink 4SU-labeled viral genomes and interacting prot
19 arrying(5), tracking, imaging(6) and partner crosslinking(7), the range of functional groups that can
24 thesized EC2629, a folate conjugate of a DNA crosslinking agent based on a novel DNA-alkylating moiet
25 The combination of HA in a high-viscosity crosslinking agent with DBG improves the bone repair pro
27 combination of DBG and HA in a low-viscosity crosslinking agent; group DBG/HV: CSD filled by the comb
33 of an amphiphilic polymer followed by three crosslinked amphiphilic polymeric layers (P(3) coating),
36 ese protein microparticles can also be photo-crosslinked and stably extracted to an all-aqueous envir
38 spectra results indicated increased collagen crosslinking and chemical reaction between the adhesive
39 els can be structurally fused by interfacial crosslinking and coupled as input and output modules to
40 (200 AzU/g) were used for IgE binding, TGase-crosslinking and functional property characterization.
43 ermore, by integrating SHAPE and fSHAPE with crosslinking and immunoprecipitation (eCLIP) of desired
46 ed with oligo (dT)-conjugated beads after UV-crosslinking and profiled by proteomics (termed mRBPome
47 n have also been suggested to be involved in crosslinking and stabilization of the lubricating superf
48 (FFPE) tissues requires reversal of chemical crosslinking and the removal of reagents that are incomp
49 enerate acetaldehyde-induced DNA interstrand crosslinks and determine their repair mechanism in Xenop
50 IP helps replisomes overcome DNA interstrand crosslinks and DNA-protein crosslinks, whereas in mitosi
52 supported using a combination of mutational, crosslinking, and kinetic analyses, and long-timescale m
53 rofiled to determine potency and the site of crosslinking, and subsequently developed as reporters in
56 tions, virtually all existing strategies for crosslinking are poorly reversible, chemically modifying
58 this work, epoxy elastomers with reversible crosslinks are synthesized by polymerizing an anthracene
60 ation of chromatin in cells mainly relies on crosslinking-based chromosome conformation capture techn
63 ith single-nucleotide resolution (XACT-seq; "crosslink-between-active-center-and-template sequencing"
66 bule sliding velocity and the number of PRC1 crosslinks but do not depend on overlap length or PRC1 d
69 ide) (PNIPAAM)-based supramolecular networks crosslinked by emissive hexagonal metallacycles is prese
70 a single macromolecule made of glycan chains crosslinked by peptide side branches that surrounds the
71 idoglycan (PG) cell wall composed of glycans crosslinked by short peptides surrounds most bacteria an
74 m concentration of mechanophores required to crosslinking by about 100-fold compared to previous exam
75 ggested different potentials for inter-spike crosslinking by IgGs on viruses, and characterized IgGs
76 ent peptidoglycan synthesis or peptidoglycan crosslinking by penicillin-binding protein 2 (PBP2) are
77 d with inhibitors that prevent peptidoglycan crosslinking by penicillin-binding protein 3 (PBP3/FtsI)
78 mimimal sequence bias and establish that the crosslink can be reversed by phosphine reduction of azid
79 h identical polymer components but different crosslinking capacities to enable the investigation of m
80 efine the repair pathways of DNA interstrand crosslinks caused by an endogenous and alcohol-derived m
81 the mechanism used to repair the interstrand crosslinks caused by the chemotherapeutic agent cisplati
82 is ability of a biparatopic antibody to both crosslink CD73 dimers and fix them in an inactive confor
83 e mechanical properties of tendon or whether crosslinking changes in response to stretching or relaxa
85 gestion showed decreased digestibility of TG-crosslinked chickpea-stabilized emulsions, while proteom
86 n Escherichia coli, cell elongation requires crosslink cleavage by PG endopeptidases to make space fo
89 ics simulations to optimise the selection of crosslinking compounds that overcome this trade-off rela
93 DNA polymerase REV1 completes repair of the crosslink, culminating in a distinct mutational spectrum
94 n alpha-actinin-4 (ACTN4)-an important actin crosslinking cytoskeletal protein that provides structur
95 sion yeast whole-cell poly(A)(+) RNA-protein crosslinking data provide information on the organizatio
97 of 4.1 angstrom and combine it with protein crosslinking data to determine the molecular architectur
99 ase (mTG) catalyses the formation of protein crosslinks, deamidating glutamine in a side-reaction.
100 mance is the spray coating of 0.73 mum thick crosslinked dense, hydrophilic polymers on to electrospu
103 n adjacent crosslinks, network mesh size and crosslinking density as a function of crosslinker additi
104 Vs to overcome the confinement, and a higher crosslinking density facilitates a fluctuating transport
105 repared from 30% v/v ethanol without calcium crosslinking displayed rapid peptic digestion in less th
107 a so far uncharacterized hurdle, DNA-protein crosslinking (DPC), by insertion sequence (IS)-mediated
108 midines induces the formation of DNA-protein crosslinks (DPCs) and causes DNA replication and transcr
109 bstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can
111 urally occurring or drug-induced DNA-protein crosslinks (DPCs) interfere with key DNA transactions if
112 Spartan (DVC-1) and Wss1 resolve DNA-protein crosslinks (DPCs), including Topoisomerase-DNA adducts,
115 , while proteomic analysis revealed that the crosslinked emulsion is a source of bioactive peptides t
116 stability (over a month) compared to the non-crosslinked emulsion that showed phase separation after
120 ncoming virion RNAs are labeled with 4SU, so crosslinking events specifically occur between proteins
122 -guided mutagenesis and in vitro and in vivo crosslinking experiments, this study provides an unprece
124 slide filaments, whereas non-motor proteins crosslink filaments into higher-order motifs, such as ov
125 Moreover, a murine model reveals that Fe(3+) crosslinked foam displays higher compatibility with subc
129 reted protein, acidic and rich in cysteine), crosslinking genes/enzymes (lysyl oxidase, lysyl oxidase
130 r micellar-like nanoparticles with reducible crosslinks have high efficacy in both 2D and 3D in vitro
135 had similar IgE-binding properties to the un-crosslinked hydrolysates, but with higher functional pro
139 S) past a nitrogen mustard-based interstrand crosslink (ICL) with an 8-atom linker between the crossl
141 h NEIL3 has been shown to unhook interstrand crosslinks (ICL) in Xenopus extracts, how NEIL3 particip
142 is crucial for the repair of DNA interstrand crosslinks (ICL), a highly toxic lesion that leads to ch
146 on of the miRNAs, high-throughput sequencing crosslinking immunoprecipitation (HITS-CLIP) and biochem
147 f gene expression changes and (iii) Enhanced Crosslinking Immunoprecipitation Sequencing (eCLIP-seq)
149 fication of microRNA (miRNA) targets by Ago2 crosslinking-immunoprecipitation (CLIP) methods has prov
151 ion and Ca(2+) flux, were measured after IgE crosslinking in murine bone marrow-derived mast cells an
153 a suggest that YAP/TAZ may regulate collagen crosslinking in the palatal shelf mesenchyme, thus contr
155 he chemical structures and topologies of the crosslinks in supramolecular networks play a crucial rol
158 ntation measurements that demonstrate ligand crosslinking increases Young's modulus and sound velocit
161 nce is available from direct measurements of crosslink levels whether these bonds contribute to the m
162 n is easily understood in terms of motor and crosslink localization, and allows for an extensive cont
163 Here, we present a femtosecond laser-induced crosslinking mass spectrometry (fliX-MS) workflow, which
164 yo-EM) structure of gammaTuRC, combined with crosslinking mass spectrometry analysis, reveals an asym
165 elaxation enhancement (PRE) NMR and chemical crosslinking mass spectrometry confirm the repressive he
168 orks (SilDNs) that participate in orthogonal crosslinking mechanisms-photocurable thiol-ene reactions
173 ial cell line), whereas DTX-loaded reducible crosslinked MLNPs exhibited higher cytotoxicity against
178 from those in which the original covalently crosslinked network is formed, often simultaneously enab
179 d with a combinational dynamic and permanent crosslinking network through chain entanglement and DNA
180 redict the molecular weight between adjacent crosslinks, network mesh size and crosslinking density a
181 chanically weak due to their heterogeneously crosslinked networks and lack of energy dissipation mech
182 nlike typical thermosets or other covalently crosslinked networks, possess a unique, often dormant ab
185 o bind MTs independently of EB1 in vitro and crosslinks nonpolymerizing MT plus ends to actin filamen
188 , as a functional mimic of a 1,2-intrastrand crosslink, occupies canonical -1 and +1 template positio
189 cascade to control the force which triggers crosslinking of a mechanochromic polymer of spirothiopyr
191 to label living bacteria followed by in vivo crosslinking of bacteria proteins to their interacting h
198 n two distinct but coupled steps, an orderly crosslinking of pilin monomers and subsequent anchoring
200 CD73 dimer in a bivalent manner, implicating crosslinking of separate CD73 dimers in its mechanism of
203 bio-orthogonal two-photon cycloaddition and crosslinking of the polymers at wavelengths longer than
204 NA interactome capture (RIC) uses in vivo UV crosslinking, oligo(dT) capture, and proteomics to ident
205 Soy and pea isolates underwent extensive crosslinking on their own, but heteropolymers were not o
206 liX-MS to cells identifies several bona fide crosslinks on DNA binding domains, paving the way for fu
207 in order to regulate microtubule-microtubule crosslinking or sliding, KIFC2 and KIFC3 need to interac
208 P-exo assay precisely delineates protein-DNA crosslinking patterns by combining chromatin immunopreci
209 suggest that principled analyses of ChIP-exo crosslinking patterns enable inference of spatial organi
210 computational framework that aligns ChIP-exo crosslinking patterns from multiple proteins across a se
214 When exposed to 365 nm UV light, additional crosslinking points are created by the photo-induced dim
215 l as the large number of contact or physical crosslinking points between adjacent BC nanofibres, furt
220 study provides a strategy to prepare cavity-crosslinked polymer networks for antibacterial applicati
222 the common strategy of utilizing mutants or crosslinking probes to stabilize intermediates is prone
223 MavC in complex with the substrate mimic and crosslinked product provide insights into the reaction m
225 induce adaptive immunity against a foreign, crosslinked protein, chicken egg ovalbumin (OVA), in the
226 he frictional forces produced by the mitotic crosslinking protein PRC1 that resist microtubule slidin
229 ughness and 3 times the strength of covalent crosslinked PSeD elastomers, while maintaining a low mod
231 e concentration of such bonds, and hence the crosslinking rate, is controlled by force-dependent diss
232 fication, is used to pull-down total RNA and crosslinked RBPs, this method facilitates investigation
240 d against acetaldehyde-induced damage by DNA crosslink repair, which when impaired causes Fanconi ana
245 However, the repair of acetaldehyde-induced crosslinks results in increased mutation frequency and a
246 ping RNAPI by Miller chromatin spreads or UV crosslinking revealed 5' enrichment and strikingly uneve
247 complex by solution scattering and chemical crosslinking, revealing a 1:2 complex that can form high
249 e Tet2 locus, we purified and sequenced TET2-crosslinked RNAs from mouse embryonic stem cells (mESCs)
251 than free rosmarinic acid, doxorubicin, non-crosslinked Rososome and commercial liposomal formulatio
252 can lock the payloads tightly, endowing the crosslinked Rososome with better stability and pharmacok
253 eneic mouse model of breast cancer, the iron-crosslinked Rososomes exhibit better anticancer efficacy
254 leavable and non-cleavable cysteine-cysteine crosslinked samples, capillary immunoblotting analysis d
256 ding sites in genomic viral RNA by detecting crosslink-specific uridine to cytidine transitions in NG
257 the large mitoribosome subunit (mtLSU), and crosslinks specifically with the 16S rRNA, and several m
258 to loss of Short stop (Shot), a cytoskeletal crosslinking spectraplakin protein that we previously fo
263 ucing consistent measurements of protein-DNA crosslinking strengths across multiple proteins, our app
265 terize the effect of thiol and allyl sulfide crosslink structures on degradation kinetics is used.
267 the BamA substrate, consistent with previous crosslinking studies(10-12); the other edges of the BamA
268 M and mechanical tests documented successful crosslinking that enhanced the structural properties of
271 vercome this thermal-transport bottleneck by crosslinking the ligands to exchange a weak van der Waal
272 ular transglutamination reaction, covalently crosslinking the Ube2N and Ub subunits effectively inact
273 synthases that polymerize glycan strands and crosslink them: class A penicillin-binding proteins (aPB
274 teins, was previously reported to covalently crosslink to DNA at abasic sites via a conserved cystein
279 hat of STP isomerization, the cascade limits crosslinking to overstressed regions of the material, wh
280 ymerization of new glycan strands with their crosslinking to the existing peptidoglycan meshwork is u
283 low concentrations, N-protein preferentially crosslinks to specific regions characterized by single-s
284 (TDP2) reverses Topoisomerase 2 DNA-protein crosslinks (TOP2-DPCs) in a direct-reversal pathway lice
287 terdomain dynamics of MMP1 on fibrin without crosslinks using single-molecule Forster Resonance Energ
288 in situ-forming hydrogel of collagen type I crosslinked via multi-functional polyethylene glycol (PE
292 e DNA interstrand crosslinks and DNA-protein crosslinks, whereas in mitosis it triggers disassembly o
297 erved over 400 specific interacting proteins crosslinked with the probe during the formation of Salmo
298 he capture antibody (CAb) was immobilized by crosslinking with glutaraldehyde (GA) on the amino group