ライフサイエンスコーパス: crossover

1 ) pai-manifold from the Fe(II)-centered spin-crossover.

2 o 96% midway through treatment, with 2 to 6% crossover.

3 hat the reaction shows no intermolecular C-H crossover.

4 BA sequence with a 10-week washout period at crossover.

5 nteract with PCNA present defects in forming crossovers.

6 loss of CDKG1 results in increased class II crossovers.

7 of protection that scales with the number of crossovers.

8 ividuals each), for which we then quantified crossovers.

9 entified Mendelian errors and most of double crossovers.

10 s homologous chromosomal pairing and class I crossovers.

11 1/DMC1, thus leading to a lower frequency of crossovers.

12 h a 10%-20% reduction in the total number of crossovers.

13 hough very high levels of diversity suppress crossovers.

14 revents deleterious, premature activation of crossovers.

15 nce limits the coincidence of closely spaced crossovers.

16 in-state selectivity, and elicit mechanistic crossovers.

17 A double-blind, randomized, controlled crossover 12-wk intervention was conducted.

18 lex has been implicated in the resolution of crossovers(5-10), but the mechanisms that activate and d

19 ect Cdc5 recruitment that triggers MutLgamma crossover activity.

20 g double-blind placebo-controlled randomized-crossover administration of the GABA reuptake inhibitor,

21 vent was examined using time-stratified case-crossover analyses, adjusted for dew point and air tempe

22 We conducted a time-stratified case-crossover analysis with conditional logistic regression

23 Here, using a sex crossover analysis, we show that sex-dependent autosomal

24 ovaginal samples were collected at baseline, crossover and exit for characterization of the microbiot

25 ion of an osteogenic marker, we used genetic crossover and random mutagenesis to generate new generat

26 t 85 K, is discontinuous and related to spin crossover and spin state ordering.

27 es from 20 sperm donors, identifying 813,122 crossovers and 787 aneuploid chromosomes.

28 romatids, Mph1(FANCM) ensures high levels of crossovers and non-crossovers between homologs.

29 ks (DSBs) enter interhomolog repair to yield crossovers and noncrossovers.

30 homologs be connected by the combination of crossovers and sister chromatid cohesion.

31 tants that are globally defective in forming crossovers and synaptonemal complex (SC), a protein scaf

32 RadD protein suppresses crossovers and Uup prevents nucleoid mis-segregation.

33 each crossover only when threshold levels of crossovers are generated.

34 Crossovers arise from recombination-mediated repair of p

35 We provide evidence that crossover association with elevated diversity is mediate

36 n peak coincides with the elastic-to-plastic crossover at low T, yet the mechanism changes at higher

37 ociated with suppression of meiotic DSBs and crossovers at the chromosome and fine scales.

38 grooves, single-strand versus double-strand crossovers, backbone phosphate positions, and single-str

39 her rigorously high-spin (6) or gradual spin-crossover behavior (5) also in the solid state.

40 recombination during meiosis, which leads to crossovers between chromosomes critical for production o

41 Orderly chromosome segregation is enabled by crossovers between homologous chromosomes in the first m

42 M) ensures high levels of crossovers and non-crossovers between homologs.

43 h4 phosphorylation enables the formation and crossover-biased resolution of double-Holliday Junction

44 that the sliding clamp PCNA is important for crossover-biased resolution.

45 icient resolution to accurately identify the crossover breakpoints in a typical trio family.

46 D-loops can be resolved as crossovers or non-crossovers, but crossover-destined D-loops may have long

47 of meiotic recombination intermediates into crossovers by an unknown mechanism(3-7).

48 Crossovers can be measured by observing the inheritance

49 gh-performance aqueous RFBs due to their low crossover capability and high abundance.

50 Overall, the radical-polar-crossover cascade entails the following key steps: (i) b

51 This was a randomized, open-label, crossover clinical trial in a tertiary hospital involvin

52 In a crossover clinical trial that assessed driving performan

53 In meiosis, crossover (CO) formation between homologous chromosomes

54 In an explosive spin crossover complex, these changes could affect the mechan

55 astic and spin state ordered phase of a spin crossover complex.

56 Spin crossover complexes are known to undergo bond length, vo

57 exes confers an advantage over two-step spin crossover complexes for future applications in devices o

58 Spin-crossover complexes with low coordination numbers are mu

59 lations indicate an indirect-direct band-gap crossover composition when x > 0.50.

60 rates, for the first time, an explosive spin crossover compound (ExSCO) that exhibits switchable impa

61 plore this relationship, the well-known spin crossover compound [Fe(Htrz)(3)](n)[ClO(4)](2n) (1) was

62 and/or electronic effects has provided spin-crossover compounds for several transition metals in the

63 eview observations on two aspects of meiotic crossover control - crossover interference and repressio

64 In this crossover controlled feeding study, 55 healthy men and w

65 Interhomolog crossovers (COs) are a prerequisite for achieving accura

66 Crossovers (COs) ensure accurate chromosome segregation

67 some-autonomous signaling and a nucleus-wide crossover-counting mechanism partitions holocentric chro

68 amage, aberrant chromosome condensation, and crossover defects in mouse spermatocytes and spontaneous

69 We performed a balanced parallel and crossover design experiment with omnivorous common bulbu

70 randomized, double-blind, placebo-controlled crossover design in 25 healthy volunteers (aged 18-25),

71 Our randomized crossover design included 27 healthy adults that underwe

72 A prospective time-delayed crossover design trial of GS to assess the efficacy of G

73 The order of the 3-phase crossover design was not randomized and there was no bli

74 currently untested hypothesis, a randomized crossover design was used in which healthy non-smokers w

75 A case-crossover design was used to investigate the association

76 ouble-blind, randomized, placebo-controlled, crossover design was used to investigate whether altered

77 In an exploratory randomized crossover design, 10 RYGB-operated patients and 10 match

78 at six urban sites in New York State, a case-crossover design, and conditional logistic regression, w

79 such as utilizing a randomized double-blind crossover design, enrolling participants likely to respo

80 double-blind, placebo-controlled, randomized crossover design, nontreatment seeking smoking participa

81 articipants, double-blinded, sham-controlled crossover design, we recorded EEG while participants wit

82 ssions in a double-blinded pseudo-randomised crossover design.

83 over two separate 56-h sessions in a random crossover design.

84 8 days apart using a randomised double-blind crossover design.

85 ations in a double-blind, placebo-controlled crossover design.

86 sample of fifty veterans with PTSD, using a crossover design.

87 asting and three 200% overfeeding diets in a crossover design.

88 cording to a longitudinal, double-blind, and crossover design.

89 3-mm overlap, synthetic 2D mammogram) with a crossover design.

90 d by the nucleoplasmic HAL-2/3 complex until crossover designation, which constrains PLK-2 to special

91 esolved as crossovers or non-crossovers, but crossover-destined D-loops may have longer lifespans.

92 Thus, the PRR19-CNTD1 complex may enable crossover differentiation by regulating CDK2.

93 To measure interference, we analyzed double crossover distances, MLH1 foci, and fluorescent pollen t

94 cebo-controlled, four-sequence, four-period, crossover, double-blind trial, patients with multiple sc

95 domized, placebo-controlled, double-blinded, crossover, double-dummy study comprising, on 4 separate

96 ectron-hole phase diagram, including BEC-BCS crossover, enabling tantalizing applications in superflu

97 software using 10X linked reads to identify crossover events at a high resolution.

98 hod can delineate a genome-wide landscape of crossover events at a precise scale, which is important

99 In humans, thousands of crossover events have been identified by genotyping rela

100 ily dataset and can efficiently discover the crossover events.

101 ion across chromosomal regions reduces risky crossover events.

102 We used a randomized crossover experiment to estimate the effects of ozone (v

103 In a within-subject, crossover experiment, the study measured anxiety in heal

104 total of 23 subjects (13 male) completed two crossover experimental sessions where binocular rivalry

105 We conducted two double-blind, randomized crossover experiments in which healthy adults (N = 23, 2

106 action rate, catalyst resting state, enolate crossover experiments, water tolerance, and the effects

107 Meiotic crossovers facilitate chromosome segregation and create

108 ulated by a co-dependent activity of the pro-crossover factors EXO1 and MutSgamma, the latter of whic

109 omere-led recombination and promoting spaced crossover formation along the chromosomes via interferen

110 which repairs DSBs but cannot complement the crossover formation defects.

111 utants reveal an important role for MEIOB in crossover formation in late meiotic recombination.

112 MEIOB causes protein degradation and reduced crossover formation in mouse testes.

113 evated diversity is mediated via the Class I crossover formation pathway, although very high levels o

114 recombination, and most are repaired without crossover formation, although one or more generate cross

115 equired for stage progression, which enables crossover formation, suggesting that the establishment o

116 he role of SC in both limiting and promoting crossover formation.

117 defects in DSB repair, homolog synapsis, and crossover formation.

118 pin (HS) states of the iron(II) Hofmann spin crossover framework, [Fe(II) (pdm)(H(2) O)[Ag(CN)(2) ](2

119 that enables high-throughput measurements of crossover frequency and interference in individual plant

120 The crossover frequency per bivalent was significantly reduc

121 Crossover frequency varies along chromosomes and crossov

122 terstitial network, leading to a macroscopic crossover from an initial bending-dominated softening re

123 as the control therapy, despite substantial crossover from control therapy to olaparib.

124 However, the substantial amount of treatment crossover from nonoperative to surgical treatment should

125 We observe a smooth crossover from the disorder-driven superconductor-normal

126 ve as a promising platform to scrutinize the crossover from two to one dimension in a controlled setu

127 tices as well as temperature- and time-tuned crossovers from elastic (collective) dynamics to plastic

128 nd exchange, explaining Mph1's apparent anti-crossover function.

129 D-loops resemble crossover gene conversions in size, but their extent is

130 Crossovers generated during the repair of programmed mei

131 To generate a crossover, hundreds of DNA double-strand breaks (DSBs) a

132 All six compounds undergo spin-crossover in solution with T(1/2) above room temperature

133 reas for negative anisotropies, we observe a crossover in the time domain from ballistic to diffusive

134 ever, study interpretation may be limited by crossover in the use of the assigned medication.

135 Therefore, we mapped crossovers in a msh2 mutant, defective in mismatch recog

136 Unlike the complexity of crossovers in yeast, these simple modifications of the o

137 n two aspects of meiotic crossover control - crossover interference and repression of crossovers near

138 Interestingly, while crossover interference is normal in asy1/+, it is undete

139 sover frequency varies along chromosomes and crossover interference limits the coincidence of closely

140 ssover location and separation, a measure of crossover interference-covaried strongly across individu

141 indicating that ASY1 is required to mediate crossover interference.

142 domized, double-blinded, placebo-controlled, crossover intervention study was conducted in 13 healthy

143 (65-70 y) were included in a double-blinded crossover intervention study, consisting of a 20-d habit

144 participated in a randomized, double-blind, crossover intervention.

145 The trial was a randomized, controlled, crossover, intervention study.

146 Carlo, and kinetic Monte Carlo suggests the crossover is a fundamental physical feature which is ins

147 The crossover junction is held together by two stacked G:C p

148 We performed randomized within-subject crossover laboratory studies in non-shift workers and sh

149 mbination phenotypes-from crossover rates to crossover location and separation, a measure of crossove

150 These mechanisms regulating meiotic crossovers may be conserved across species.

151 The radical-polar crossover mechanism is supported by various experimental

152 s operates through a reductive radical-polar crossover mechanism where aryl halide reduction triggers

153 eas by way of a photocatalytic radical-polar crossover mechanism.

154 determined using a 2-phase linear regression crossover model to identify a breakpoint in 13CO2 produc

155 ons were examined using time-stratified case-crossover models, controlling for temporal trends and me

156 ractical technique named multifactorial peak crossover (MPC) via computer-assisted chromatographic mo

157 Crossovers must be properly placed along meiotic chromos

158 l - crossover interference and repression of crossovers near centromeres, both observed more than 85

159 We observed quantitative variation in total crossover number with a maximum of a 1.4-fold difference

160 DNA double-strand-break repair, and reduced crossover number.

161 reinforces the tightly regulated control of crossover numbers without requiring its catalytic activi

162 To generate crossovers, numerous double-strand breaks (DSBs) are int

163 ver formation, although one or more generate crossovers on each chromosome.

164 ng SYP-1 phosphorylation on one side of each crossover only when threshold levels of crossovers are g

165 RPA-bound D-loops can be resolved as crossovers or non-crossovers, but crossover-destined D-l

166 ncluding donor choice and the possibility of crossover outcome.

167 g from 0.01 to 0.05 aneuploidies per gamete; crossovers partially protected chromosomes from nondisju

168 A putative pai-allyl palladium radical-polar crossover path is proposed as a key event in this three-

169 reaction conditions enabled a radical-polar crossover pathway wherein two distinct electrophiles can

170 cally reconstituted key elements of this pro-crossover pathway.

171 h a Cu(II)-azide species via a radical-polar crossover pathway.

172 ) which favoured the SC-independent class II crossover pathway.

173 ed on the intention-to-treat population with crossover patients analysed in the placebo group; analys

174 y analyses were based on treatment received; crossover patients were counted in the placebo group up

175 in the overall safety population and within crossover patients.

176 in combination with the observed changes in crossover patterning suggest a difference in how chromat

177 icipants who provided complete data for both crossover phases included 67% women, were 69% Caucasian,

178 2) , mean +/- SD) completed this randomized, crossover, placebo-controlled trial during two laborator

179 pting PX-based architectures or by strategic crossover placement.

180 ure were 8.9 for ruxolitinib and 8.8 for the crossover population), though most anaemia events were m

181 ure were 8.0 for ruxolitinib and 8.2 for the crossover population).

182 The case-crossover populations for switching from VKA to DOAC and

183 A new study shows that crossover position influences the successful completion

184 In nuclei with fully synapsed homologues and crossover precursors, removing different meiosis-specifi

185 Many crossover products yielded no heteroduplex DNA, suggesti

186 SC-deficient, crossover-proficient mutants ecm11 and gmc2 experienced

187 ty of a multistranded motif called paranemic crossover (PX) DNA.

188 DESIGN, SETTING, AND PARTICIPANTS: Cluster crossover randomized clinical trial conducted at 50 ICUs

189 Using a crossover, randomized, double-blind and placebo-controll

190 we found no significant association between crossover rate and structural variation at the 200-400 k

191 ) there is abundant variation in genome-wide crossover rate in natural populations, (2) at the 200-40

192 ) analysis, we found that this difference in crossover rate was dramatically higher than expected und

193 ah population displayed on average 8% higher crossover rates than the Arizona population, a statistic

194 Diverse recombination phenotypes-from crossover rates to crossover location and separation, a

195 hts the emerging opportunities for exciting "crossover" reactivity offered by these derivatives of th

196 allows repair by long tract gene conversion, crossover recombination and break-induced replication (B

197 s essential for stable homologue pairing and crossover recombination in diverse eukaryotes, it is unk

198 Crossover recombination is critical for meiotic chromoso

199 Crossover recombination is essential for accurate chromo

200 duced by a regulated program and repaired by crossover recombination to establish a tether between ho

201 field case for the purpose of extracting the crossover region between the ferromagnetic and paramagne

202 urations that extends to the extraction of a crossover region in a way that is consistent with expect

203 ng MRLR, we revealed a fine-scale pattern of crossover regions in six human families.

204 However, most of these crossover regions span tens to hundreds of kb, which is

205 ast to gain temporal and genetic traction on crossover regulation, we find that MutLgamma constitutiv

206 e heterozygous and homozygous regions causes crossover remodelling towards the heterozygous regions i

207 Upon commitment to crossover repair, MutLgamma-Exo1 associate with recombin

208 These data highlight similarities between crossover resolution and the initiation steps of DNA mis

209 A central principle of crossover resolution is that the two Holliday junctions

210 Biased crossover resolution was observed, consistent with asymm

211 Lgamma) endonuclease complex is critical for crossover resolution, which involves mechanistically unc

212 Meiotic crossovers result from homology-directed repair of DNA d

213 dramatic reduction in the number of class I crossovers, resulting in univalents at metaphase I and p

214 Our results reveal a pro-crossover role for MSH2 in regions of higher sequence di

215 ic susceptibility measurements indicate spin-crossover (SCO) behaviour with a T(1/2) of 130 K, lower

216 d on the cause of the switching: light, spin crossover (SCO), redox, temperature, and wettability.

217 ander used for nephroprotection) in a random crossover sequence to evaluate biodistribution, pharmaco

218 In wild type, the majority of crossovers show interference, meaning that they are more

219 rimary outcome, done to assess the effect of crossovers, showed higher rates of mRS 0-3 at 90 days in

220 trace the cause of PX's biostability to DNA crossovers, showing a continuum of protection that scale

221 ions holocentric chromosomes relative to the crossover site, which ultimately defines the pattern of

222 Furthermore, PCNA localizes to prospective crossover sites along synapsed chromosomes.

223 PLK-2 is targeted to crossover sites primed by CDK-1 and spreads along the SC

224 PRR19 and CNTD1 co-localise at crossover sites, physically interact, and are interdepen

225 MutLgamma nuclease activation might explain crossover-specific processing of Holliday junctions or t

226 d for timely DSB repair and the formation of crossover-specific recombination complexes.

227 dent kinase, CDK2, which also accumulates in crossover-specific recombination complexes.

228 fined, the differentiation and maturation of crossover-specific recombination intermediates requires

229 ch repair(12,13) and evoke a novel model for crossover-specific resolution of double Holliday junctio

230 g interhomolog events from non-crossovers to crossover-specific strand exchange, explaining Mph1's ap

231 control (as we see with case-cohort and case-crossover studies, for example).

232 ubstudy of UChoose, an open-label randomized crossover study (NCT02404038), comparing acceptability a

233 participated in a double-blind, randomized, crossover study at a contract research organization.

234 We performed a secondary cohort-crossover study comparing the risk of cervical artery di

235 a double-blind, randomized, counterbalanced, crossover study comprising 23 healthy human participants

236 Utilising a double-blind, randomised crossover study design, we recruited 20 healthy male par

237 stries, we conducted a population-based case-crossover study evaluating the association between switc

238 (2); 5 females) participated in a randomized crossover study in free-living conditions.

239 ed for a double-blinded, placebo-controlled, crossover study including 6 experimental days in a rando

240 a double-blind, randomized, sham-controlled, crossover study involving two sessions of neurofeedback

241 d inpatient hospital admissions in this case-crossover study of adult patients visiting a large urban

242 e completed a randomized, placebo-controlled crossover study of empagliflozin 10 mg daily versus plac

243 andomized, double-blind, placebo-controlled, crossover study of one dose of 50 mg of naltrexone, or p

244 This larger double-blind crossover study that included healthy controls investiga

245 andomized, double-blind, placebo-controlled, crossover study to examine dose-related effects of AV-10

246 d, double-blind, placebo-controlled, two-way crossover study was conducted.

247 randomised controlled non-blinded eight-arm crossover study was used to assess plasma nicotine pharm

248 ngle phthalate, DBP.Methods: In a randomized crossover study, 16 allergen-sensitized participants wer

249 led in a double-blinded, placebo-controlled, crossover study, and peripheral blood was collected at b

250 In a randomized crossover study, the effect of injectable norethisterone

251 During both phases of the crossover study, vomiting scores were higher in the grou

252 In a randomized crossover study, we found that GES reduced the frequency

253 randomized, double-blind, placebo-controlled crossover study.

254 a single-blind, randomized, case-controlled crossover study.

255 to the chromosome axis, resulting in reduced crossover suppression across pericentromeric regions.

256 tention-to-treat analysis not accounting for crossover, the probability of survival at 5 years was 91

257 In the case-crossover, there was also an increase in cardiovascular

258 ineate the empirical trends in solution spin-crossover thermodynamics.

259 with electrochemical dissolution and sulfur crossover through the membrane induced specific changes

260 n terms of the anomalous exponent alpha, the crossover time t(cross), and the limits D(0) and D(infin

261 des, beyond [Formula: see text] results in a crossover to a new regime in which the characteristic si

262 Crossover to acalabrutinib was allowed in patients who p

263 al dialysis (PD) underwent randomization and crossover to either a 2-hour dwell with 1 L DSR solution

264 Crossover to half-dose PDT after previous unsuccessful H

265 ved anatomic and functional endpoints, while crossover to HSML after half-dose PDT does not seem to s

266 Crossover to olaparib was allowed after imaging-based di

267 The impact of control crossover to PTXDs, cause-specific mortality, and drug d

268 d time (through year 8, excluding time after crossover to surgery).

269 way pressure for 2 hours (phase 3), and then crossover to the other phase for 2 hours; during phase 4

270 ine or IV decitabine in cycle 1, followed by crossover to the other treatment in cycle 2.

271 lacebo group; analyses were not adjusted for crossover to the pertuzumab group and are likely to be c

272 Crossover to the protective effect of pregnancy is depen

273 on high MW (>10 kDa) PEO and the P(R(ee))'s crossover to the theoretical distribution for an exclude

274 among remaining interhomolog events from non-crossovers to crossover-specific strand exchange, explai

275 prisingly, asy1/+ heterozygotes also remodel crossovers toward subtelomeric regions at the expense of

276 Patients received crossover treatment with either half-dose PDT or HSML.

277 ation, which can be effectively managed with crossover treatment.

278 e conducted a 6-week, randomized, open-label crossover trial comparing amiloride/hydrochlorothiazide

279 conducted a multicenter, cluster-randomized, crossover trial comparing two schedules for pediatric re

280 We performed a randomized, 3-way crossover trial in 14 healthy volunteers who ingested 7.

281 andomized, double-blind, placebo-controlled, crossover trial in 223 healthy men and women aged 18-70

282 We did a pragmatic cluster-randomised crossover trial in 29 UK pharmacies among women receivin

283 Methods: First, an interventional crossover trial in adult subjects with ARDS and BMI >=35

284 This randomized crossover trial in Quetzaltenango, Guatemala included 26

285 OmniHeart is a randomized crossover trial of 164 men and women (>=30 y old); 163 p

286 ntext of a double-blind, placebo-controlled, crossover trial of ketamine in 33 individuals with treat

287 andomized, double-blind, placebo-controlled, crossover trial of patients with type 2 diabetes and hea

288 Our randomized, controlled, crossover trial took place at 4 mosques randomized to an

289 e studied by home-polygraphy in a randomized crossover trial using either midline-traction with restr

290 A pilot double-blind, placebo-controlled crossover trial was conducted (ClinicalTrials.gov, NCT02

291 In this multicenter cluster-randomized crossover trial, 10 French ICUs were randomly assigned (

292 In the randomized crossover trial, 12 volunteers successively consumed 2 d

293 rate 4-wk, placebo-controlled, double-blind, crossover trials, 50 healthy adults with low dietary fib

294 ariable and error-prone: rates of chromosome crossover vary among gametes, between the sexes, and amo

295 ach pair of chromosomes attains at least one crossover via the formation and biased resolution of rec

296 Unplanned crossover was high (15%), so to assess efficacy we perfo

297 Placebo to ivosidenib crossover was permitted on radiological progression per

298 two closest heterozygous alleles around the crossovers, we determined that MRLR achieved a median re

299 Crossovers were elevated in the diverse pericentromeric

300 dergoes a thermally induced Fe-centered spin-crossover which yields significant diradical character o