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1  the endocytic receptors megalin (gp330) and cubilin.
2 o inhibit albumin binding to both regions of cubilin.
3 y a role in the intracellular trafficking of cubilin.
4 sulted in reduced cell surface expression of cubilin.
5 aused by defect of a gene product other than cubilin.
6 ndividual protein affinities for megalin and cubilin.
7 of the main scavenger receptors, MEGALIN and CUBILIN.
8 ubule (PT) multiligand receptors megalin and cubilin.
9 ugh the multiligand receptor complex megalin-cubilin.
10 studies of AMN function and coevolution with cubilin.
11 , identifying p400 as the murine ortholog of cubilin.
12          Working in concert with megalin and cubilin, a nonselective multireceptor complex that predo
13                    In cubilin transfectants, cubilin accumulated in early biosynthetic compartments.
14 undance of the albumin receptors megalin and cubilin, affect albumin endocytosis in the proximal tubu
15                     Here, we investigate the cubilin-albumin binding interaction to define the impact
16  a model of the key amino acids required for cubilin-albumin binding.
17 into the binding interface necessary for the cubilin-albumin interaction.
18 that cubilin and AMN are subunits of a novel cubilin/AMN (cubam) complex, where AMN binds to the amin
19 own, suggesting evolutionary conservation of Cubilin/AMN co-receptors function from flies to humans.
20                   Furthermore, we found that Cubilin/AMN-mediated protein reabsorption is required fo
21  to albumin overload prompted an increase in CUBILIN, AMNIONLESS and CLCN5 gene expression.
22 overload first acts on the expression of the cubilin-amnionless (CUBAM) complex in these cells, then
23 in EECs of the nutrient receptor triad, LRP2-cubilin-amnionless, changes significantly.
24          Yolk components endocytosed by LRP2-cubilin-amnionless, preformed and newly formed lipid dro
25 eral ligands and interacting proteins in the cubilin-amnionless-megalin complex that are involved in
26             Two large receptors, megalin and cubilin/amnionless (CUBAM), bind to and efficiently retr
27 , composed of the scavenger receptor complex Cubilin/Amnionless and Dab2, that is required for protei
28 merase chain reaction-amplified fragments of cubilin, an endocytic receptor of molecular mass 460 kDa
29                             CUBN encodes for cubilin, an intestinal and proximal tubular uptake recep
30                     These data indicate that cubilin and AMN are subunits of a novel cubilin/AMN (cub
31                            Here we show that cubilin and AMN colocalize in the endocytic apparatus of
32 ophila genes encoding orthologs of mammalian cubilin and amnionless (AMN), two major receptors for pr
33 of 2 genes encoding the epithelial proteins: cubilin and amnionless (AMN).
34 ere AMN binds to the amino-terminal third of cubilin and directs subcellular localization and endocyt
35  predicts that downregulation of megalin and cubilin and hyperfiltration both contribute significantl
36                                              Cubilin and megalin exhibited coincident patterns of mRN
37   Tracer endocytosis by nephrocytes required Cubilin and reflected size selectivity analogous to that
38 ably streptavidin, the vitamin B12 receptor, cubilin, and integrin alpha(v)beta(5).
39                                              Cubilin antibodies inhibit HDL endocytosis by the endode
40 pendence of ligand binding or the ability of cubilin antiserum to inhibit ligand binding to the 113-r
41 ependence or inhibition of ligand binding by cubilin antiserum.
42                                  Megalin and cubilin are cooperating receptors essential to the proxi
43    These studies show the great potential of cubilin as a new target for the delivery of B(12) based
44 ntrations and reduced amounts of megalin and cubilin at the proximal tubule cell surface in Rab38 kno
45                      This is consistent with cubilin being an endogenous partner of galectin-3 at the
46                To further define the albumin-cubilin binding site, we determined the solution structu
47 mented that carbamylated albumin had reduced cubilin binding, but the effects of cubilin modification
48 receptor-mediated endocytosis by the megalin-cubilin complex.
49  mediated endocytosis facilitated by megalin-cubilin complex.
50 ver, in cells cotransfected with AMN and the cubilin construct, cubilin trafficked to the cell surfac
51 ther AMN or a truncated IF-cobalamin-binding cubilin construct, neither protein alone conferred ligan
52              These results indicate that (a) cubilin contains two distinct regions that bind both IF-
53                                              Cubilin (Cubn) is a multiligand endocytic receptor criti
54            Biallelic mutations either in the cubilin (CUBN) or amnionless (AMN) gene cause IGS.
55  the C3 epimer of 25(OH)D3 [3-epi-25(OH)D3]; cubilin (CUBN) with 25(OH)D3; 25-hydroxylase (CYP2R1) wi
56 umans, AMN has been genetically connected to Cubilin (CUBN), a multi-ligand scavenger receptor expres
57 te lipid uptake via the multiligand receptor Cubilin (Cubn), leading to the ectopic accumulation of l
58                                              Cubilin deficiency leads to urinary loss of albumin and
59 he basis of these findings, we conclude that cubilin deficiency reduces renal salvage and delivery ba
60 electrophoresis demonstrated that in megalin/cubilin-deficient mice an increased amount of (99m)Tc-DM
61                         We have used megalin/cubilin-deficient mice produced by gene knockout to dete
62          The reduced renal uptake in megalin/cubilin-deficient mice was accompanied by an increase in
63                           Control or megalin/cubilin-deficient mice were injected intravenously with
64                                   In megalin/cubilin-deficient mice, we observed decreased uptake and
65 MSA was identified in scintigrams of megalin/cubilin-deficient mice.
66 d that RENTAC conjugates showed megalin- and cubilin-dependent endocytic uptake in the immortalized k
67 motic diuresis, hypertrophy, and megalin and cubilin downregulation, without stipulating changes in g
68 robe, a B(12) conjugate of rhenium 2, in the cubilin expressing placental choriocarcinoma BeWo cell l
69 orrelating with a reduction in renal megalin/cubilin expression in knockout mice to about 10% of norm
70 nt, with concomitantly decreased megalin and cubilin expression levels and increased TfR1 expression.
71 ssibility that therapeutic increase of renal cubilin expression might reduce proteinuria and increase
72 mbryo yolk-sac endoderm, a prominent site of cubilin expression.
73 min but not IF-Cbl binding to the N-terminal cubilin fragment that included the eight EGF-like repeat
74 es of seven tryptic peptides were similar to cubilin from rats, humans, and dogs, identifying p400 as
75                   Albuminuria due to reduced cubilin function could be an unexpectedly common benign
76 roteinuria who had biallelic variants in the cubilin gene (CUBN).
77                  Using mice heterozygous for cubilin gene deletion (cubilin HT mice), we show that cu
78                         Amnionless (AMN) and cubilin gene products appear to be essential functional
79  binding interaction to define the impact of cubilin glycosylation and map the key glycosylation site
80 ene deletion (cubilin HT mice), we show that cubilin haploinsufficiency leads to reduced renal proxim
81                                        Since cubilin has been reported to bind the endocytic receptor
82                                              Cubilin has recently been shown to function as an endocy
83  pathways: receptor-mediated endocytosis via cubilin (high affinity) and megalin (low affinity), and
84  normally filtered albumin is reabsorbed via cubilin; however, megalin-mediated uptake predominates u
85 ressed in the liver, kidney, or intestine of cubilin HT mice did not change significantly.
86                                    Moreover, cubilin HT mice displayed significantly decreased blood
87 mice heterozygous for cubilin gene deletion (cubilin HT mice), we show that cubilin haploinsufficienc
88 l) from the blood increased significantly in cubilin HT mice.
89 otted and probed with anti-megalin IgG, anti-cubilin IgG, or receptor-associated protein.
90 study, we show that the germline ablation of Cubilin impairs endodermal and mesodermal patterning, an
91       Our results reveal essential roles for Cubilin in early embryonic development, and suggest that
92     We further confirm the essential role of Cubilin in nutrient internalization by the early viscera
93  downregulation of the receptors megalin and cubilin in PT cells and hyperfiltration both contribute
94 an important role for the C-terminal half of cubilin in renal albumin reabsorption.
95 interface and suggests an important role for cubilin in uNK cell function.
96 ant role for glycosylation in regulating the cubilin interaction with albumin, which is altered in pr
97 us validating the system for analysis of AMN-cubilin interactions.
98                                              Cubilin is a high molecular weight multiligand receptor
99                                              Cubilin is an endocytic receptor highly expressed in ren
100 and proteinuria occurs in 50% of cases since cubilin is coreceptor for both the intestinal vitamin B(
101 ot uNK cells, implying that yolk sac-derived cubilin is endocytosed by uNK cells via galectin-3.
102   These findings, coupled with the fact that cubilin is expressed in kidney proximal tubules, suggest
103                                              Cubilin is the only known receptor for holo-IF and is fo
104  endocytosis of the glomerular filtrate, and cubilin is the proximal tubule brush border membrane gly
105 DL, or apoA-I, it was found to copurify with cubilin isolated by HDL-Sepharose affinity chromatograph
106                                   Inhibiting cubilin led to a reduction in albumin uptake, highlighti
107                                  Megalin and cubilin levels detected by immunochemiluminescence were
108 lly increased internalization of the megalin-cubilin ligand albumin as well as the fluid phase marker
109 alpha1-microglobulin, an established megalin/cubilin ligand.
110 min and apoA-I; however, the consequences of cubilin loss on the homeostasis of blood albumin and apo
111 ation of 2 was confirmed to proceed in an IF-cubilin mediated fashion via siRNA transfection experime
112 godeoxynucleotides resulted in inhibition of cubilin-mediated endocytosis of HDL.
113 in and accumulates in the kidneys by megalin/cubilin-mediated endocytosis of the (99m)Tc-DMSA protein
114                                              Cubilin-mediated HDL endocytosis is inhibitable by HDL(2
115  (IF) vitamin B(12) ileum anchored receptor, cubilin, mediates endocytotic uptake of the IF complex o
116 -mediated endocytosis, involving megalin and cubilin, mediates renal proximal-tubular reabsorption an
117             We show that these cells express cubilin, megalin, ClC-5, amnionless and Dab2, which are
118 ors, ligands and interacting proteins in the cubilin-megalin multiligand endocytic receptor complex a
119 rk Pathway analysis included 12 genes in the cubilin-megalin multiligand endocytic receptor complex.
120  reduced cubilin binding, but the effects of cubilin modifications on binding albumin remain unclear.
121               In situ hybridization revealed cubilin mRNA in yolk sac epithelium but not uNK cells, i
122  human Imerslund-Grasbeck syndrome caused by cubilin mutations.
123 y, visceral endoderm dispersal is impeded in Cubilin null embryos.
124                                              Cubilin occurred in yolk sac epithelium throughout pregn
125 avenger receptor megalin and its co-receptor cubilin play a vital role in retrieving low molecular we
126  mutations abrogate AMN expression and block cubilin processing and targeting to the apical membrane.
127  visceral yolk sac of RFC1-/- embryos, while cubilin protein was widely misexpressed.
128 ent transmembrane and cytoplasmic domains in cubilin raises questions as to the means by which it can
129             Although the role of the megalin-cubilin receptor complex (MCRC) in this process is unequ
130 DMSA is thus critically dependent on megalin/cubilin receptor function and therefore is a marker of p
131  could be used as a targeting moiety for the cubilin receptor systemically, has not been investigated
132 l for B12 absorption in the GI tract via the cubilin receptor, could be used as a targeting moiety fo
133 n receptor-expressing CA20948 and megalin or cubilin receptor-expressing BN-16 cells, in the absence
134 hways, consisting of high-affinity uptake by cubilin receptors, low-affinity uptake by megalin recept
135                                              Cubilin recognizes intrinsic factor (IF)-cobalamin and v
136 a and that normal brush-border expression of cubilin requires the activity of an accessory protein.
137 BN, encoding the co-transporters megalin and cubilin, respectively, that mediate proximal tubule prot
138 ation mouse embryos, where interactions with cubilin result in nutrient endocytosis, and it may be im
139 ier 2, rs72691774, p = 1.9x10(-8)] and CUBN (cubilin, rs565051161, p = 3.9x10(-8)).
140 ite, we determined the solution structure of cubilin's albumin-binding domain, CUB7,8, using small-an
141  whereas nephrotic conditions or knockout of cubilin shifts the bulk of albumin uptake to S2.
142 d progressive loss of expression of megalin, cubilin, sodium-glucose cotransporter 2, and type IIa so
143  that in addition to its nutritive function, Cubilin sustains signaling pathways involved in embryoni
144 e used mice with kidneys lacking megalin and cubilin, the coreceptors that mediate proximal tubular e
145                  We previously reported that Cubilin, the endocytic receptor for intrinsic factor-vit
146 DL affinity chromatography and identified as cubilin, the recently described endocytic receptor for i
147 d posttranslational stability of megalin and cubilin, the receptors that bind to and recover filtered
148  demonstrate that megalin acts together with cubilin to mediate HDL endocytosis and further suggest t
149 bility that megalin acts in conjunction with cubilin to mediate HDL endocytosis.
150 nsfected with AMN and the cubilin construct, cubilin trafficked to the cell surface and endosomes, an
151                                           In cubilin transfectants, cubilin accumulated in early bios
152                                Unexpectedly, cubilin was found only in perforin-containing granules o
153 ding the intrinsic factor (IF)-B12 receptor, cubilin, was recently cloned; the human homologue, CUBN,
154                       The measured levels of cubilin were normal for all patients.
155  subcellular localization and endocytosis of cubilin with its ligand.
156 n associations of variants in CUBN, encoding cubilin, with the urinary albumin-to-creatinine ratio (U

 
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