ライフサイエンスコーパス: culminate

1 A global Neogene cooling trend culminated ~7 million years ago with the onset of Greenl

2 This event culminated a half-century effort around the globe to dev

3 The recent decrease in US life expectancy culminated a period of increasing cause-specific mortali

4 ory fusion in parietal-temporal regions, and culminating as causal inference in the frontal lobe.

5 esidue level in the aza-glycine backbone and culminate at the macromolecular level of the triple heli

6 on-sulfur clusters to perform this reaction, culminating at the FeMco active site (M = Mo, V, Fe), wh

7 A steep increase occurs after the 1940s culminating during the 1970s, at the same time as the ma

8 Our results culminate in a demonstration leveraging this information

9 ing discrete phases of clinical testing that culminate in a large randomized superiority trial has hi

10 athogenic GC B cell and macrophage reactions culminate in antibody formation and TGF-beta secretion,

11 d inflammation, and lysosomal anomalies that culminate in behavioral and motor deficiencies.

12 chanisms associated with these products that culminate in cellular responses.

13 lmonary complications), which can eventually culminate in clinical conditions ranging from portal and

14 e-to-innate synapse-like contacts ultimately culminate in DC-to-MC molecule transfers including major

15 erventions that stop invasion processes that culminate in deleterious outcomes and/or that expedite m

16 peciation induces physiological changes that culminate in differences in global metabolism, cellular

17 eactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AA

18 rases (and other supporting components) that culminate in elevated [CO2] inside a chloroplastic Rubis

19 w interactions between different liver cells culminate in fibrosis development in NASH, focusing on t

20 tion of innate and adaptive immune responses culminate in immunothrombosis, ultimately causing (micro

21 ing mechanisms during stress that eventually culminate in its delayed impact on the amygdala.

22 Targeting the molecular pathways that culminate in lysis of neutrophils during CA-MRSA infecti

23 dergo a specialized series of reactions that culminate in NET formation.

24 w developmental changes in neuronal function culminate in network dysfunction that underlies sensory

25 rarchical genomic and regulatory states that culminate in neutrophil or macrophage specification in m

26 heavy-handed response to infection that may culminate in organ failure and death.

27 action and differentiation of myofibroblasts culminate in pathologic deposition of collagen.

28 of KP activation appear in patients with AD, culminate in patients with ACLF, and may be involved in

29 hophysiological pathways and mechanisms that culminate in poor outcomes associated with sarcopenia.

30 Persistent insulin secretion defects culminate in progressive deficits in beta-cell prolifera

31 Most forms of chronic kidney disease culminate in renal fibrosis that heralds organ failure.

32 nary artery remodeling that can subsequently culminate in right heart failure and premature death.

33 reveals the paths of signal integration that culminate in seed germination and provides a resource to

34 These perturbations can culminate in significant morbidity and mortality, usuall

35 ts on patients' quality of life, which often culminate in social withdrawal, unemployment, depression

36 g synthetic strategies, some of the sections culminate in tables containing comparisons of various me

37 s through pathways that converge on IRF3 and culminate in the cleavage of caspase-3.

38 progressing through firing-rate epochs that culminate in the emergence of action-related firing.

39 These two pathways culminate in the formation of stimulus-specific NPAS4 he

40 Mitochondrial and lysosomal anomalies culminate in the generation of short-lived tissue-invasi

41 coordination of many endocrine factors that culminate in the production of mature, viable gametes.

42 d cyclical and how its features interact and culminate in unsafe care.

43 Some viral infections culminate in very different outcomes in different indivi

44 erepressing and sustaining its expression to culminate in virus production.

45 Previous work culminated in 1 (NEU-1953), which was part of a series t

46 Development culminated in a route to ABBV-168 featuring a de novo ch

47 020 advocacy and program implementation have culminated in a universal reduction of combined age-stan

48 e chronology of immune-related problems that culminated in allograft necrosis and the eventual loss o

49 cal changes that developed over 2-4 days and culminated in cell death.

50 contributed to immunological signaling that culminated in colon inflammation.

51 the reduction in the expression of each gene culminated in different responses in terms of plant grow

52 in Rayleigh-charged water/sulfolane droplets culminated in electrostatically driven protein expulsion

53 d experimental advances of recent years have culminated in establishing (13)C-Metabolic Flux Analysis

54 These structural and mechanistic insights culminated in GSK065(C1) and GSK366(C2), molecules suita

55 ctate in exchange for uric acid reabsorption culminated in hyperuricemia and gout.

56 y MD runs on larger droplets (5.5 nm radius) culminated in IEM ejection of ubiquitin, as long as the

57 glycolysis and HIF-1alpha expression, which culminated in IL-1beta induction thereby simulating pseu

58 has been riddled with financial turmoil that culminated in its rapid closure in summer 2019.

59 ion of this unique crown-color signal likely culminated in premating isolation of the hybrid species

60 al deposition have been developed, which has culminated in recent approval of a budesonide effervesce

61 ptors are the differentiating features which culminated in selection of 5al for further development.

62 ata, MD runs in the absence of Ca(2+) and Ax culminated in target binding site closure.

63 ce of the desert in a long-term process that culminated in the abandonment of much of the settled are

64 These deleterious effects culminated in the activation of the mitochondrial apopto

65 ts to generate such semi-synthetic organisms culminated in the creation of a strain of Escherichia co

66 ed series of allosteric TrkA inhibitors that culminated in the delivery of candidate quality compound

67 decade, which has, in my own field of study, culminated in the determination of ribosome structure at

68 Structure-activity relationship studies culminated in the development of a superior CA analogue

69 the context of oncogenic Kras, Kras(G12D) , culminated in the development of highly aggressive and m

70 Our efforts have culminated in the development of the first total synthes

71 These adaptations culminated in the differentiation of a novel digestive s

72 ting point for a drug discovery program that culminated in the discovery of 103 (AZD1979).

73 These efforts have culminated in the discovery of 4-({5-[4-fluoro-1-(2H-ind

74 These efforts have culminated in the discovery of 5-[2-amino-3-(1-methyl-1H

75 d optimization of pharmacokinetic properties culminated in the discovery of AB680, a highly potent (K

76 The effort described herein culminated in the discovery of ACT-1004-1239 (28f).

77 These efforts culminated in the discovery of BMS-986166 (14a), which w

78 tions in brain, permeability, and low efflux culminated in the discovery of compound 1, which exhibit

79 rsible covalent drug discovery program which culminated in the discovery of compound 34 (PRN1371), a

80 This work culminated in the discovery of LNP023 (41), which is cur

81 Iteration of these efforts culminated in the discovery of MK-2640, and its in vitro

82 Chemical optimization of 3 using SBDD culminated in the discovery of the potent and selective

83 ecular editing focusing on the linker design culminated in the discovery of the self-immolative l-Phe

84 These studies culminated in the discovery of TNO155, (3S,4S)-8-(6-amin

85 to alkyl and aryl groups, additional efforts culminated in the expansion of the scope of the substitu

86 These efforts have culminated in the first successful biomimetic catalyst c

87 ceutical optimization of the resulting leads culminated in the identification of AMG 510, a highly po

88 eversible thiourea inhibitors of ABHD12 that culminated in the identification of DO264 as a potent, s

89 ty permitted by the tunnel pharmacophore and culminated in the identification of pyrazolopyrimidinone

90 of intense research for many decades and has culminated in the synthesis of a large variety of block

91 This culminated in two tool molecules, 20 (GSK620) and 56 (GS

92 ly postnatal life wherein partial amputation culminates in a localized regeneration instead of global

93 s, the programs associated with T cell aging culminates in a maladaptive response that directly contr

94 (ICE), the accessibility of the naphthoates culminates in a new synthesis of anthraquinones and dias

95 suggesting that mPFC-BLA circuit maturation culminates in a period of exuberant GABAergic transmissi

96 cascade of conserved proteins and small RNAs culminates in accumulation of the transcription factor L

97 a G(12/13)-dependent signaling cascade that culminates in activation of the Hippo pathway effectors

98 d differential expression of VEGF-A isoforms culminates in alterations in gonadotroph function opposi

99 This culminates in an extremely poor clinical outcome.

100 This culminates in an increase of the qubit's inhomogeneous d

101 ylation and a cascade of post-NRPS reactions culminates in an intramolecular [4+2] hetero-Diels-Alder

102 urotransmitter-activated signal transduction culminates in catalytic phosphorylation of the tunable r

103 gen I, by hepatic stellate cells (HSCs) that culminates in cirrhosis.

104 oner of the axonal degeneration pathway that culminates in depletion of axonal NAD(+), yet the identi

105 mulatory networks at the T-cell surface that culminates in effector function and subsequent aGVHD in

106 The DDR culminates in either transient cell-cycle arrest and DNA

107 depolarization and electrical activity that culminates in elevation of [Ca(2+) ](i) and initiation o

108 diate RuCl(2)(CAAC)(=CH(2)), a reaction that culminates in elimination of the methylidene ligand as e

109 ar cell (VC) fetal reprogramming upon stress culminates in end-stage heart failure (HF) by mechanisms

110 Infiltration of infected leukocytes culminates in establishment of a brain niche for Human I

111 functions as a potent tumour suppressor and culminates in extensive cell death.

112 els an accelerating disease progression that culminates in failure of mitochondrial energy production

113 (systole) in aged animals, where their loss culminates in fibrillatory cardiac arrest.

114 ls by a complex differentiation process that culminates in fusion of mononuclear osteoclast precursor

115 priate to perform germline gene editing that culminates in human pregnancy.

116 l center-like differentiation program, which culminates in immortalized, proliferating cells that par

117 This culminates in increased collagen deposition and a thicke

118 nd activation of peritoneal B1b cells, which culminates in increased lamina propria and luminal IgA.

119 lts influences the localization process that culminates in large brittle rupture events.

120 which it activates a signaling cascade that culminates in many of the functional outcomes attributed

121 r the control of transcriptional factors and culminates in mature neutrophils with a broad armamentar

122 ionate host response to infection that often culminates in multiple organ failure.

123 stress-induced glutamate excitotoxicity that culminates in neuron injury and manifests as re-experien

124 transitions to eight weeks of research, and culminates in one week at the Rosetta annual conference.

125 ) is a progressive motor neuron disease that culminates in paralysis and death.

126 s a renal tubule injury-like response, which culminates in progressive tubulointerstitial fibrosis (T

127 ge in a stereotyped "dance," that this dance culminates in proper spindle positioning and orientation

128 ained during childhood, and its reactivation culminates in puberty initiation.

129 y promoting cyst formation that, ultimately, culminates in renal failure.

130 This translational control culminates in reprogramming of the transcriptome to faci

131 drives the cystic lung remodeling that often culminates in respiratory failure.

132 highly conserved neurohormonal cascade that culminates in systemic secretion of glucocorticoids.

133 idues, causing a domino chain of events that culminates in target binding site closure.

134 proteins initiates a cascade of events that culminates in the activation of surface complement recep

135 The study culminates in the asymmetric synthesis of backbone-subst

136 Hedgehog (Hh) signaling culminates in the conversion of the latent transcription

137 ionally depicted as a signaling cascade that culminates in the formation of an autophagosome that deg

138 Bacillus subtilis is a communal process that culminates in the formation of architecturally complex m

139 kes progressive telomere decondensation that culminates in the inception of persistent telomere repli

140 decline driven by damage accumulation, often culminates in the mortality of a cell lineage.

141 Hematopoiesis culminates in the production of functionally heterogeneo

142 es reinitiation of viral gene expression and culminates in the production of infectious progeny.

143 exhibits a 48-hour developmental cycle that culminates in the synchronous release of parasites from

144 elective entry to ryanoids is described that culminates in the synthesis of anhydroryanodol and thus

145 betes is an autoimmune-mediated disease that culminates in the targeted destruction of insulin-produc

146 The respiratory cascade of bacteria culminates in the terminal transfer of electrons onto hi

147 fferentiation at sites of tissue injury that culminates in transformed barriers composed of scar and

148 y 40% of the drug employed during treatment, culminating in a >12.5-fold increase in therapeutic pote

149 orylation capacity and increased ROS levels, culminating in a bioenergetic catastrophe.

150 articipants were included in 2 groups each), culminating in a consensus meeting attended by experts (

151 ted interest in the infectious theory of AD, culminating in a debate on the topic at the Alzheimer's

152 unting protein synthesis and mTOR signaling, culminating in a decline of Mcl-1.

153 rase REV1 completes repair of the crosslink, culminating in a distinct mutational spectrum.

154 rarchy of increasingly severe approximations culminating in a generalized version of the so-called "c

155 runcating mutations cause haploinsufficiency culminating in a recognizable syndrome with intellectual

156 atum corneum of Irf6(-/-) skin was abnormal, culminating in a severe defect in the function of the ep

157 2 leads to the loss of the anergic phenotype culminating in a significantly compromised life expectan

158 ccumulated about MMN over the past 30 years, culminating in a state-of-the-art approach to therapy.

159 g the Spindlin1 and SPINDOC protein complex, culminating in a structural model with two SPINDOC molec

160 n relay based on judicious substrate design, culminating in a two-phase synthesis of Taxol.

161 e disease, dementia and Parkinson's disease, culminating in a workshop to develop a unified framework

162 ally generate five levels of representations culminating in action-specific motor signals.

163 tion and integrity decline rapidly with age, culminating in activity-dependent, non-apoptotic cell de

164 neumophila causes life-threatening pneumonia culminating in acute lung injury.

165 MAPK and NF-kappaBp65 activation, ultimately culminating in amelioration of excess collagen synthesis

166 oral and spatial control of gene expression, culminating in an asymmetric cell division yielding dist

167 hibits SDF-1alpha/CXCR4-mediated chemotaxis, culminating in an impaired response to beta-amyloid plaq

168 g protein-like 1), leads to retinal diseases culminating in blindness.

169 d stem cell proliferation and exhaustion and culminating in bone marrow failure.

170 of p27 and PUMA in a panel of cancer cells, culminating in cell death.

171 tion leads to inflammation and liver damage, culminating in cirrhosis, the penultimate step in the pr

172 : 3500 boys and leads to muscle dysfunction culminating in death due to respiratory or cardiac failu

173 acterized by progressive neurological injury culminating in death, typically by 3 years of age.

174 s hemorrhagic fever, organ damage, and shock culminating in death, with case fatality rates as high a

175 and expression of c-fos in BMMs (p < 0.01), culminating in decreased NFATc1 protein expression and t

176 the use of energetically efficient habitats culminating in decreased trout fitness.

177 ositol-requiring protein 1alpha (IRE1alpha), culminating in defective XBP1 splicing.

178 e deficits in anterior mesoderm populations, culminating in defects to anterior embryonic structures,

179 redox circuits in cardiac cells, ultimately culminating in disturbances of autophagy/mitophagy fluxe

180 evealed a complex and multifactorial process culminating in dysregulation of MC function and an aberr

181 r IL5 expression by CXCR2+ lung neutrophils, culminating in early lung injury.

182 imprints on the DNA sequence of tumours, and culminating in empirical evidence from NGS data that wel

183 ieving more gentle and reversible lithiation culminating in enhanced cyclability of batteries.

184 drugs leads to long-lasting neuroadaptations culminating in excessive drug intake.

185 an sulfate results in neurological symptoms, culminating in extensive neurodegeneration and early dea

186 prolonged brain-specific VEGF overexpression culminating in extensive, highly selective loss of DG GC

187 peciation resulting in biodiversity decline, culminating in extinction events near the Devonian-Carbo

188 rities identified by nominal group technique culminating in formal voting were to better leverage exi

189 of inflammatory and pathological processes, culminating in formation of a scar.

190 acts as the first step in a series of events culminating in fusion with the host cell membrane and tr

191 in the stemness of hair follicle stem cells, culminating in hair loss.

192 rogressive and severe diastolic dysfunction, culminating in heart failure.

193 ate spirocycles followed by its fine-tuning, culminating in highly selective compounds 21 and 22.

194 II) machinery for production of viral mRNAs culminating in host transcriptional shut off.

195 expansion and CAR T cell antitumor efficacy, culminating in improvement in survival in a syngeneic mo

196 ocyte lengthening load, and atrial function, culminating in increased LV filling pressures.

197 o most abundant PDK isoforms, PDK2 and PDK3, culminating in increased PDH activation in mutant cells.

198 tions of vessels accumulate throughout life, culminating in increased risk of developing CVD.

199 y stimuli via a PI3K-mTORC2-mediated pathway culminating in induction of the enzyme glucokinase (GCK)

200 eregulation of early development checkpoints culminating in inefficient differentiation of CD4(+)CD8(

201 erous lytic mRNAs and proteins are produced, culminating in infectious virion production.

202 gonistic allostery in ISRIB action on eIF2B, culminating in inhibition of the ISR.

203 ncreasingly active and predatory lifestyles, culminating in jawed vertebrates that dominate modern ve

204 NA damage responses (DDRs) at the telomeres, culminating in karyotypic alterations with massive array

205 gh an intricate mechanism involving RhoA and culminating in Kv1.1 overfunction, which could be target

206 a specific context to auxin response maxima culminating in leaf primordia initiation.

207 ns or development of a hypercoagulable state culminating in life-threatening thrombosis, highlighting

208 nocytes to propagate a hypercoagulable state culminating in life-threatening thrombosis.

209 gain a better understanding of the processes culminating in liver failure and cancer and to prioritiz

210 oss of poly(PR)-positive cells, and gliosis, culminating in motor and memory impairments.

211 ice held a value stream analysis in FY 2013, culminating in multiple rapid process improvement worksh

212 eurons induces both apoptosis and autophagy, culminating in neuron death.

213 elineated at the molecular level, ultimately culminating in new therapeutics that have revolutionized

214 p has been intensively investigated recently culminating in novel strategies and improved protocols w

215 pulmonary bypass (CPB) provokes inflammation culminating in organ dysfunction and increased mortality

216 feedback initiates a surge of GnRH release, culminating in ovulation.

217 eripheral C-terminal ligand binding site and culminating in pore opening.

218 BH3 family members BimEL, Harakiri,and Puma, culminating in preservation of mitochondria in the degen

219 of kidney diseases and cell senescence, both culminating in progressive deterioration of renal functi

220 conditions involves several distinct events, culminating in rapid assembly of fibrillar aggregates th

221 tion impairs MICU1 processing and stability, culminating in reactive oxygen species (ROS) production

222 r membrane models to multicomponent systems, culminating in realistic models of an increasing variety

223 lipolysis and increased de novo lipogenesis, culminating in reduced energy expenditure, glucose toler

224 ability or (4) reduced PSEN1 maturation, all culminating in reduced gamma-secretase carboxypeptidase-

225 flammation leads to macrophage reprogramming culminating in reduced proinflammatory and increased ant

226 toward the tropics throughout the Cenozoic, culminating in relatively narrow circumtropical distribu

227 rease excitatory drive into the hippocampus, culminating in seizure activity and SUDEP.

228 a phenotypic roadmap of disease progression culminating in serially transplantable leukemia.

229 ntially and spatially choreographed program, culminating in seven spatially arranged unilineage proge

230 and, attenuates IFN-induced STAT1 signaling, culminating in significantly abrogated activation of gen

231 n physical activity or food consumption, all culminating in significantly reduced weight gain and adi

232 levels and activation of a signaling cascade culminating in Slug induction, epithelial-to-mesenchymal

233 e of significant pathology in other tissues, culminating in stroke and severe neurological deficits w

234 n-presenting cells (APCs) and donor T cells, culminating in T-cell differentiation along pathogenic t

235 ts are encoded by double or triple paralogs, culminating in tens of EXO70 paralogs.

236 s of the unfolded protein response (UPR) and culminating in terminal UPR activation.

237 pe lectin-like receptor signaling mechanisms culminating in the activation of the antiinflammatory ar

238 However, the signal transduction pathways culminating in the biological consequences of VEGF signa

239 ffects of VacA on endolysosomal trafficking, culminating in the clearance of intracellular bacteria.

240 istry optimization of the benzylamine series culminating in the discovery of 12, an orally bioavailab

241 eminal role in guiding optimization efforts, culminating in the discovery of balovaptan (RG7314, RO52

242 series of CELMoDs for the treatment of RRMM, culminating in the discovery of CC-92480, a novel protei

243 ty against two LAR subtype cell line models, culminating in the discovery of compound 30 (CIDD-006710

244 tcomings and enhance efficacy are discussed, culminating in the discovery of preclinical development

245 of a new class of aminoglycoside antibiotics culminating in the discovery of propylamycin.

246 antibacterial activity in vitro and in vivo, culminating in the discovery of unprecedented substituen

247 y a substantial decline across the boundary, culminating in the extinction of several important clade

248 is and an increased risk of type 2 diabetes, culminating in the failure of insulin secretion from pan

249 sequential stages of TLS maturation in LSCC culminating in the formation of germinal centers (GC).

250 r evidence of a specific interaction network culminating in the full genomic set has yet to be identi

251 veals the cascade of energy conversion steps culminating in the generation of ATP from sunlight.

252 integration into both human and mouse cells culminating in the generation of the ODInCas9 mouse.

253 ic architecture along the Atlantic seaboard, culminating in the great passage tomb complexes, is part

254 he densely recurrent primate ventral stream, culminating in the inferior temporal (IT) cortex.

255 t is associated with additional alterations, culminating in the loss of functional rag genes in some

256 m an inter-organellar circuit initiating and culminating in the mitochondrion.

257 ebellar nuclei and ventromedial thalamus and culminating in the mPFC.

258 ds by a stepwise sequence of cellular events culminating in the PAD4-mediated expulsion of DNA.

259 red since the first release of the software, culminating in the recent 2.5 release.

260 ded with drier positive PNA-like conditions, culminating in the staggered abandonment of many major N

261 to a remarkable degree in the last 5 years, culminating in the successful correction of a cardiomyop

262 of this strategy was successfully realized, culminating in the synthesis of oridamycin A and oridamy

263 The studies culminating in the synthesis of two large subunits of ta

264 velopment of an efficient masticatory system-culminating in the tribosphenic apparatus-allowed early

265 al, NMR, kinetic and theoretical approaches, culminating in the unprecedented detection and quantific

266 ology, and platelet production and function, culminating in thrombocytopenia and platelet dysfunction

267 1 +/- 0.4 Tg CH(4) yr(-1) from 2010 to 2015, culminating in total anthropogenic and natural emissions

268 ite insensitivity to cardiac glycosides(16), culminating in triple mutant 'monarch flies' that were a

269 , and inhibited the dysfunctional phenotype, culminating in tumor growth inhibition.

270 ctivation of the Raf/MEK/ERK kinase cascade, culminating in upregulation of CDK1 with subsequent SAMH

271 ons of calves latently infected with BoHV-1, culminating in virus shedding and transmission.

272 of salt and water into the intestinal lumen, culminating in watery diarrhea.

273 opment of various SMN replacement strategies culminating, in December 2016, in the approval of the fi

274 meostasis and low-grade chronic inflammation culminate into metabolic syndrome that increase the risk

275 Pregnancy is a stress factor culminating into mild endoplasmic reticulum (ER) stress,

276 , the varying mechanistic consequences often culminate to generate inappropriate regulation of neuron

277 cts with diabetes mellitus in particular, to culminate with arguments pro and con and a practical ris

278 leton-mediated FA growth and maturation thus culminate with FA traction oscillation to drive efficien

279 Belt, crustal thickening began at 240 Ma and culminated with 60-70-km-thick crust at 215 Ma.

280 Our optimization strategy culminated with in vivo active RO7101556 (18B) having ex

281 This culminated with potent 17beta-HSD3 inhibitors 23, 27, 31

282 The meeting culminated with the adoption of the special Gramado Decl

283 tion into the in vivo propagation of (S)-ZNA culminated with the demonstration of the first synthetic

284 This work culminated with the discovery of PROTAC 23, which we dem

285 k Death of 1348 and the later epidemics that culminated with the Great Plague of 1665, we estimate th

286 The interaction culminates with a collapse of B. graminis haustoria, the

287 The development program typically culminates with a comparative clinical efficacy study.

288 This pathway culminates with addition of the C21-O-O* peroxyl adduct

289 Our study culminates with the application of the tandem reaction s

290 This integrated pathway culminates with the direct phosphorylation of the crucia

291 The interaction of sperm and egg culminates with the fusion of their cell membranes, trig

292 y) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous

293 erol depletion triggers a signaling cascade, culminating with contraction impairment and myofibril di

294 itions, beginning with spore germination and culminating with establishment of a systemic infection.

295 professional development while working, and culminating with mentoring the next generation.

296 change in its global structure, subsequently culminating with over-supercoiled form through in-path i

297 and industry over the past several decades, culminating with the advent of and improvements in recha

298 is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion

299 requires a coordinated multi-tissue response culminating with the formation of a complex vascular net

300 th rates in batch cultures during log phase, culminating with the onset of stationary phase.