ライフサイエンスコーパス: culminate in

1 Previous work culminated in 1 (NEU-1953), which was part of a series t

2 Our results culminate in a demonstration leveraging this information

3 ing discrete phases of clinical testing that culminate in a large randomized superiority trial has hi

4 Development culminated in a route to ABBV-168 featuring a de novo ch

5 020 advocacy and program implementation have culminated in a universal reduction of combined age-stan

6 ly postnatal life wherein partial amputation culminates in a localized regeneration instead of global

7 s, the programs associated with T cell aging culminates in a maladaptive response that directly contr

8 (ICE), the accessibility of the naphthoates culminates in a new synthesis of anthraquinones and dias

9 suggesting that mPFC-BLA circuit maturation culminates in a period of exuberant GABAergic transmissi

10 y 40% of the drug employed during treatment, culminating in a >12.5-fold increase in therapeutic pote

11 orylation capacity and increased ROS levels, culminating in a bioenergetic catastrophe.

12 articipants were included in 2 groups each), culminating in a consensus meeting attended by experts (

13 ted interest in the infectious theory of AD, culminating in a debate on the topic at the Alzheimer's

14 unting protein synthesis and mTOR signaling, culminating in a decline of Mcl-1.

15 rase REV1 completes repair of the crosslink, culminating in a distinct mutational spectrum.

16 rarchy of increasingly severe approximations culminating in a generalized version of the so-called "c

17 r the miR-29 family in obesity and diabetes, culminating in a hierarchical and dose-dependent effect

18 runcating mutations cause haploinsufficiency culminating in a recognizable syndrome with intellectual

19 atum corneum of Irf6(-/-) skin was abnormal, culminating in a severe defect in the function of the ep

20 2 leads to the loss of the anergic phenotype culminating in a significantly compromised life expectan

21 ccumulated about MMN over the past 30 years, culminating in a state-of-the-art approach to therapy.

22 g the Spindlin1 and SPINDOC protein complex, culminating in a structural model with two SPINDOC molec

23 n relay based on judicious substrate design, culminating in a two-phase synthesis of Taxol.

24 e disease, dementia and Parkinson's disease, culminating in a workshop to develop a unified framework

25 cascade of conserved proteins and small RNAs culminates in accumulation of the transcription factor L

26 ally generate five levels of representations culminating in action-specific motor signals.

27 a G(12/13)-dependent signaling cascade that culminates in activation of the Hippo pathway effectors

28 tion and integrity decline rapidly with age, culminating in activity-dependent, non-apoptotic cell de

29 neumophila causes life-threatening pneumonia culminating in acute lung injury.

30 e chronology of immune-related problems that culminated in allograft necrosis and the eventual loss o

31 d differential expression of VEGF-A isoforms culminates in alterations in gonadotroph function opposi

32 MAPK and NF-kappaBp65 activation, ultimately culminating in amelioration of excess collagen synthesis

33 This culminates in an extremely poor clinical outcome.

34 This culminates in an increase of the qubit's inhomogeneous d

35 ylation and a cascade of post-NRPS reactions culminates in an intramolecular [4+2] hetero-Diels-Alder

36 oral and spatial control of gene expression, culminating in an asymmetric cell division yielding dist

37 hibits SDF-1alpha/CXCR4-mediated chemotaxis, culminating in an impaired response to beta-amyloid plaq

38 athogenic GC B cell and macrophage reactions culminate in antibody formation and TGF-beta secretion,

39 ng to the leakage of lysosomal contents that culminates in apoptotic cell death.

40 rylation and its membrane translocation that culminates in augmented autophagy with concomitant G2/M

41 d inflammation, and lysosomal anomalies that culminate in behavioral and motor deficiencies.

42 g protein-like 1), leads to retinal diseases culminating in blindness.

43 d stem cell proliferation and exhaustion and culminating in bone marrow failure.

44 The overall response to this stress may culminate in cardiac muscle atrophy.

45 urotransmitter-activated signal transduction culminates in catalytic phosphorylation of the tunable r

46 cal changes that developed over 2-4 days and culminated in cell death.

47 of p27 and PUMA in a panel of cancer cells, culminating in cell death.

48 chanisms associated with these products that culminate in cellular responses.

49 gen I, by hepatic stellate cells (HSCs) that culminates in cirrhosis.

50 tion leads to inflammation and liver damage, culminating in cirrhosis, the penultimate step in the pr

51 lmonary complications), which can eventually culminate in clinical conditions ranging from portal and

52 contributed to immunological signaling that culminated in colon inflammation.

53 interactions (P(Het) 0.0003-6.3 x 10(-12)), culminating in contrasting estimates of trait variance e

54 da-5) initiates multiple signaling cascades, culminating in cytotoxicity and type I IFN production in

55 e-to-innate synapse-like contacts ultimately culminate in DC-to-MC molecule transfers including major

56 : 3500 boys and leads to muscle dysfunction culminating in death due to respiratory or cardiac failu

57 acterized by progressive neurological injury culminating in death, typically by 3 years of age.

58 s hemorrhagic fever, organ damage, and shock culminating in death, with case fatality rates as high a

59 opment of various SMN replacement strategies culminating, in December 2016, in the approval of the fi

60 and expression of c-fos in BMMs (p < 0.01), culminating in decreased NFATc1 protein expression and t

61 the use of energetically efficient habitats culminating in decreased trout fitness.

62 ositol-requiring protein 1alpha (IRE1alpha), culminating in defective XBP1 splicing.

63 e deficits in anterior mesoderm populations, culminating in defects to anterior embryonic structures,

64 erventions that stop invasion processes that culminate in deleterious outcomes and/or that expedite m

65 oner of the axonal degeneration pathway that culminates in depletion of axonal NAD(+), yet the identi

66 peciation induces physiological changes that culminate in differences in global metabolism, cellular

67 the reduction in the expression of each gene culminated in different responses in terms of plant grow

68 eactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AA

69 redox circuits in cardiac cells, ultimately culminating in disturbances of autophagy/mitophagy fluxe

70 evealed a complex and multifactorial process culminating in dysregulation of MC function and an aberr

71 r IL5 expression by CXCR2+ lung neutrophils, culminating in early lung injury.

72 mulatory networks at the T-cell surface that culminates in effector function and subsequent aGVHD in

73 The DDR culminates in either transient cell-cycle arrest and DNA

74 in Rayleigh-charged water/sulfolane droplets culminated in electrostatically driven protein expulsion

75 rases (and other supporting components) that culminate in elevated [CO2] inside a chloroplastic Rubis

76 depolarization and electrical activity that culminates in elevation of [Ca(2+) ](i) and initiation o

77 diate RuCl(2)(CAAC)(=CH(2)), a reaction that culminates in elimination of the methylidene ligand as e

78 imprints on the DNA sequence of tumours, and culminating in empirical evidence from NGS data that wel

79 ar cell (VC) fetal reprogramming upon stress culminates in end-stage heart failure (HF) by mechanisms

80 ieving more gentle and reversible lithiation culminating in enhanced cyclability of batteries.

81 d experimental advances of recent years have culminated in establishing (13)C-Metabolic Flux Analysis

82 Infiltration of infected leukocytes culminates in establishment of a brain niche for Human I

83 drugs leads to long-lasting neuroadaptations culminating in excessive drug intake.

84 functions as a potent tumour suppressor and culminates in extensive cell death.

85 an sulfate results in neurological symptoms, culminating in extensive neurodegeneration and early dea

86 prolonged brain-specific VEGF overexpression culminating in extensive, highly selective loss of DG GC

87 peciation resulting in biodiversity decline, culminating in extinction events near the Devonian-Carbo

88 els an accelerating disease progression that culminates in failure of mitochondrial energy production

89 (systole) in aged animals, where their loss culminates in fibrillatory cardiac arrest.

90 w interactions between different liver cells culminate in fibrosis development in NASH, focusing on t

91 rities identified by nominal group technique culminating in formal voting were to better leverage exi

92 of inflammatory and pathological processes, culminating in formation of a scar.

93 ls by a complex differentiation process that culminates in fusion of mononuclear osteoclast precursor

94 acts as the first step in a series of events culminating in fusion with the host cell membrane and tr

95 These structural and mechanistic insights culminated in GSK065(C1) and GSK366(C2), molecules suita

96 ar1 membrane binding is elevated, ultimately culminating in GTP hydrolysis, which may destabilize the

97 in the stemness of hair follicle stem cells, culminating in hair loss.

98 rogressive and severe diastolic dysfunction, culminating in heart failure.

99 ate spirocycles followed by its fine-tuning, culminating in highly selective compounds 21 and 22.

100 II) machinery for production of viral mRNAs culminating in host transcriptional shut off.

101 priate to perform germline gene editing that culminates in human pregnancy.

102 ctate in exchange for uric acid reabsorption culminated in hyperuricemia and gout.

103 y MD runs on larger droplets (5.5 nm radius) culminated in IEM ejection of ubiquitin, as long as the

104 glycolysis and HIF-1alpha expression, which culminated in IL-1beta induction thereby simulating pseu

105 Manipulating this cellular circuit culminating in IL-2 production could have clinical benef

106 l center-like differentiation program, which culminates in immortalized, proliferating cells that par

107 tion of innate and adaptive immune responses culminate in immunothrombosis, ultimately causing (micro

108 expansion and CAR T cell antitumor efficacy, culminating in improvement in survival in a syngeneic mo

109 This culminated in increased DNA damage already at 20 weeks o

110 This culminates in increased collagen deposition and a thicke

111 nd activation of peritoneal B1b cells, which culminates in increased lamina propria and luminal IgA.

112 ertical LIV realigned the cell cytoskeleton, culminating in increased cell stiffness.

113 ocyte lengthening load, and atrial function, culminating in increased LV filling pressures.

114 o most abundant PDK isoforms, PDK2 and PDK3, culminating in increased PDH activation in mutant cells.

115 tions of vessels accumulate throughout life, culminating in increased risk of developing CVD.

116 y stimuli via a PI3K-mTORC2-mediated pathway culminating in induction of the enzyme glucokinase (GCK)

117 eregulation of early development checkpoints culminating in inefficient differentiation of CD4(+)CD8(

118 erous lytic mRNAs and proteins are produced, culminating in infectious virion production.

119 gonistic allostery in ISRIB action on eIF2B, culminating in inhibition of the ISR.

120 This strategy culminates in isolation of the first formal Ce horizonta

121 ing mechanisms during stress that eventually culminate in its delayed impact on the amygdala.

122 has been riddled with financial turmoil that culminated in its rapid closure in summer 2019.

123 ncreasingly active and predatory lifestyles, culminating in jawed vertebrates that dominate modern ve

124 NA damage responses (DDRs) at the telomeres, culminating in karyotypic alterations with massive array

125 gh an intricate mechanism involving RhoA and culminating in Kv1.1 overfunction, which could be target

126 lts influences the localization process that culminates in large brittle rupture events.

127 a specific context to auxin response maxima culminating in leaf primordia initiation.

128 ns or development of a hypercoagulable state culminating in life-threatening thrombosis, highlighting

129 nocytes to propagate a hypercoagulable state culminating in life-threatening thrombosis.

130 gain a better understanding of the processes culminating in liver failure and cancer and to prioritiz

131 Targeting the molecular pathways that culminate in lysis of neutrophils during CA-MRSA infecti

132 The cascade that culminates in macrometastases is thought to be mediated

133 which it activates a signaling cascade that culminates in many of the functional outcomes attributed

134 scade through communities, with effects that culminate in mass extinction.

135 r the control of transcriptional factors and culminates in mature neutrophils with a broad armamentar

136 oss of poly(PR)-positive cells, and gliosis, culminating in motor and memory impairments.

137 e liver failure to develop sepsis, which may culminate in multiple organ failure and death.

138 ionate host response to infection that often culminates in multiple organ failure.

139 ice held a value stream analysis in FY 2013, culminating in multiple rapid process improvement worksh

140 dergo a specialized series of reactions that culminate in NET formation.

141 w developmental changes in neuronal function culminate in network dysfunction that underlies sensory

142 stress-induced glutamate excitotoxicity that culminates in neuron injury and manifests as re-experien

143 eurons induces both apoptosis and autophagy, culminating in neuron death.

144 rarchical genomic and regulatory states that culminate in neutrophil or macrophage specification in m

145 elineated at the molecular level, ultimately culminating in new therapeutics that have revolutionized

146 p has been intensively investigated recently culminating in novel strategies and improved protocols w

147 transitions to eight weeks of research, and culminates in one week at the Rosetta annual conference.

148 heavy-handed response to infection that may culminate in organ failure and death.

149 pulmonary bypass (CPB) provokes inflammation culminating in organ dysfunction and increased mortality

150 feedback initiates a surge of GnRH release, culminating in ovulation.

151 ) is a progressive motor neuron disease that culminates in paralysis and death.

152 action and differentiation of myofibroblasts culminate in pathologic deposition of collagen.

153 of KP activation appear in patients with AD, culminate in patients with ACLF, and may be involved in

154 nd other stimuli trigger a signaling cascade culminating in phosphoinositide-phospholipase C (PLC) ac

155 echanism via a light-triggered redox cascade culminating in photooxidation of a yet unknown substrate

156 ulatory subunit of PKA (PRKAR1alpha) content culminating in PKA-site dependent phosphorylation of car

157 activate proper responses that will finally culminate in plant adaptations to optimize their growth

158 hophysiological pathways and mechanisms that culminate in poor outcomes associated with sarcopenia.

159 eripheral C-terminal ligand binding site and culminating in pore opening.

160 ion of this unique crown-color signal likely culminated in premating isolation of the hybrid species

161 BH3 family members BimEL, Harakiri,and Puma, culminating in preservation of mitochondria in the degen

162 Persistent insulin secretion defects culminate in progressive deficits in beta-cell prolifera

163 s a renal tubule injury-like response, which culminates in progressive tubulointerstitial fibrosis (T

164 of kidney diseases and cell senescence, both culminating in progressive deterioration of renal functi

165 ge in a stereotyped "dance," that this dance culminates in proper spindle positioning and orientation

166 sative agent of chronic prostatitis possibly culminating in prostate cancer, is reduced in SFM of ESR

167 ained during childhood, and its reactivation culminates in puberty initiation.

168 conditions involves several distinct events, culminating in rapid assembly of fibrillar aggregates th

169 tion impairs MICU1 processing and stability, culminating in reactive oxygen species (ROS) production

170 r membrane models to multicomponent systems, culminating in realistic models of an increasing variety

171 al deposition have been developed, which has culminated in recent approval of a budesonide effervesce

172 lipolysis and increased de novo lipogenesis, culminating in reduced energy expenditure, glucose toler

173 ability or (4) reduced PSEN1 maturation, all culminating in reduced gamma-secretase carboxypeptidase-

174 flammation leads to macrophage reprogramming culminating in reduced proinflammatory and increased ant

175 toward the tropics throughout the Cenozoic, culminating in relatively narrow circumtropical distribu

176 Most forms of chronic kidney disease culminate in renal fibrosis that heralds organ failure.

177 y promoting cyst formation that, ultimately, culminates in renal failure.

178 This translational control culminates in reprogramming of the transcriptome to faci

179 drives the cystic lung remodeling that often culminates in respiratory failure.

180 nary artery remodeling that can subsequently culminate in right heart failure and premature death.

181 during the two decade long Rome process now culminating in Rome IV.

182 ructural and functional decline with ageing, culminating in sarcopenia.

183 reveals the paths of signal integration that culminate in seed germination and provides a resource to

184 rease excitatory drive into the hippocampus, culminating in seizure activity and SUDEP.

185 ptors are the differentiating features which culminated in selection of 5al for further development.

186 a phenotypic roadmap of disease progression culminating in serially transplantable leukemia.

187 ntially and spatially choreographed program, culminating in seven spatially arranged unilineage proge

188 These perturbations can culminate in significant morbidity and mortality, usuall

189 and, attenuates IFN-induced STAT1 signaling, culminating in significantly abrogated activation of gen

190 n physical activity or food consumption, all culminating in significantly reduced weight gain and adi

191 levels and activation of a signaling cascade culminating in Slug induction, epithelial-to-mesenchymal

192 ts on patients' quality of life, which often culminate in social withdrawal, unemployment, depression

193 e of significant pathology in other tissues, culminating in stroke and severe neurological deficits w

194 highly conserved neurohormonal cascade that culminates in systemic secretion of glucocorticoids.

195 n-presenting cells (APCs) and donor T cells, culminating in T-cell differentiation along pathogenic t

196 g synthetic strategies, some of the sections culminate in tables containing comparisons of various me

197 ata, MD runs in the absence of Ca(2+) and Ax culminated in target binding site closure.

198 idues, causing a domino chain of events that culminates in target binding site closure.

199 ts are encoded by double or triple paralogs, culminating in tens of EXO70 paralogs.

200 s of the unfolded protein response (UPR) and culminating in terminal UPR activation.

201 s through pathways that converge on IRF3 and culminate in the cleavage of caspase-3.

202 progressing through firing-rate epochs that culminate in the emergence of action-related firing.

203 s of S. aureus bloodstream infections, which culminate in the establishment of abscess lesions.

204 row ingression during early development that culminate in the formation of an epithelial sheet.

205 These two pathways culminate in the formation of stimulus-specific NPAS4 he

206 Mitochondrial and lysosomal anomalies culminate in the generation of short-lived tissue-invasi

207 coordination of many endocrine factors that culminate in the production of mature, viable gametes.

208 ce of the desert in a long-term process that culminated in the abandonment of much of the settled are

209 These deleterious effects culminated in the activation of the mitochondrial apopto

210 ts to generate such semi-synthetic organisms culminated in the creation of a strain of Escherichia co

211 ed series of allosteric TrkA inhibitors that culminated in the delivery of candidate quality compound

212 decade, which has, in my own field of study, culminated in the determination of ribosome structure at

213 Structure-activity relationship studies culminated in the development of a superior CA analogue

214 the context of oncogenic Kras, Kras(G12D) , culminated in the development of highly aggressive and m

215 Our efforts have culminated in the development of the first total synthes

216 These adaptations culminated in the differentiation of a novel digestive s

217 ting point for a drug discovery program that culminated in the discovery of 103 (AZD1979).

218 These efforts have culminated in the discovery of 4-({5-[4-fluoro-1-(2H-ind

219 These efforts have culminated in the discovery of 5-[2-amino-3-(1-methyl-1H

220 These studies culminated in the discovery of 6-(4-amino-4-methylpiperi

221 d optimization of pharmacokinetic properties culminated in the discovery of AB680, a highly potent (K

222 The effort described herein culminated in the discovery of ACT-1004-1239 (28f).

223 These efforts culminated in the discovery of BMS-986166 (14a), which w

224 tions in brain, permeability, and low efflux culminated in the discovery of compound 1, which exhibit

225 rsible covalent drug discovery program which culminated in the discovery of compound 34 (PRN1371), a

226 This work culminated in the discovery of LNP023 (41), which is cur

227 Iteration of these efforts culminated in the discovery of MK-2640, and its in vitro

228 Chemical optimization of 3 using SBDD culminated in the discovery of the potent and selective

229 ecular editing focusing on the linker design culminated in the discovery of the self-immolative l-Phe

230 These studies culminated in the discovery of TNO155, (3S,4S)-8-(6-amin

231 to alkyl and aryl groups, additional efforts culminated in the expansion of the scope of the substitu

232 These efforts have culminated in the first successful biomimetic catalyst c

233 This medicinal chemistry effort culminated in the identification of 52, a potent and hig

234 This work culminated in the identification of a simplified tris-ba

235 ceutical optimization of the resulting leads culminated in the identification of AMG 510, a highly po

236 eversible thiourea inhibitors of ABHD12 that culminated in the identification of DO264 as a potent, s

237 ty permitted by the tunnel pharmacophore and culminated in the identification of pyrazolopyrimidinone

238 protein pair mediating this event in mammals culminated in the identification of the glycosylphosphat

239 Research on elicitins culminated in the recent cloning of the elicitin respons

240 of intense research for many decades and has culminated in the synthesis of a large variety of block

241 proteins initiates a cascade of events that culminates in the activation of surface complement recep

242 The study culminates in the asymmetric synthesis of backbone-subst

243 Hedgehog (Hh) signaling culminates in the conversion of the latent transcription

244 itrogen-fixing soil bacteria called rhizobia culminates in the development of root nodules, where rhi

245 ionally depicted as a signaling cascade that culminates in the formation of an autophagosome that deg

246 Bacillus subtilis is a communal process that culminates in the formation of architecturally complex m

247 between leguminous plants and soil rhizobia culminates in the formation of nitrogen-fixing organs ca

248 kes progressive telomere decondensation that culminates in the inception of persistent telomere repli

249 decline driven by damage accumulation, often culminates in the mortality of a cell lineage.

250 Hematopoiesis culminates in the production of functionally heterogeneo

251 es reinitiation of viral gene expression and culminates in the production of infectious progeny.

252 exhibits a 48-hour developmental cycle that culminates in the synchronous release of parasites from

253 elective entry to ryanoids is described that culminates in the synthesis of anhydroryanodol and thus

254 betes is an autoimmune-mediated disease that culminates in the targeted destruction of insulin-produc

255 The respiratory cascade of bacteria culminates in the terminal transfer of electrons onto hi

256 pe lectin-like receptor signaling mechanisms culminating in the activation of the antiinflammatory ar

257 gh time is a key feature of human evolution, culminating in the advanced capacity for ecosystem engin

258 However, the signal transduction pathways culminating in the biological consequences of VEGF signa

259 ffects of VacA on endolysosomal trafficking, culminating in the clearance of intracellular bacteria.

260 istry optimization of the benzylamine series culminating in the discovery of 12, an orally bioavailab

261 eminal role in guiding optimization efforts, culminating in the discovery of balovaptan (RG7314, RO52

262 series of CELMoDs for the treatment of RRMM, culminating in the discovery of CC-92480, a novel protei

263 ty against two LAR subtype cell line models, culminating in the discovery of compound 30 (CIDD-006710

264 tcomings and enhance efficacy are discussed, culminating in the discovery of preclinical development

265 of a new class of aminoglycoside antibiotics culminating in the discovery of propylamycin.

266 antibacterial activity in vitro and in vivo, culminating in the discovery of unprecedented substituen

267 y a substantial decline across the boundary, culminating in the extinction of several important clade

268 is and an increased risk of type 2 diabetes, culminating in the failure of insulin secretion from pan

269 sequential stages of TLS maturation in LSCC culminating in the formation of germinal centers (GC).

270 r evidence of a specific interaction network culminating in the full genomic set has yet to be identi

271 veals the cascade of energy conversion steps culminating in the generation of ATP from sunlight.

272 integration into both human and mouse cells culminating in the generation of the ODInCas9 mouse.

273 ic architecture along the Atlantic seaboard, culminating in the great passage tomb complexes, is part

274 he densely recurrent primate ventral stream, culminating in the inferior temporal (IT) cortex.

275 t is associated with additional alterations, culminating in the loss of functional rag genes in some

276 m an inter-organellar circuit initiating and culminating in the mitochondrion.

277 ebellar nuclei and ventromedial thalamus and culminating in the mPFC.

278 ds by a stepwise sequence of cellular events culminating in the PAD4-mediated expulsion of DNA.

279 red since the first release of the software, culminating in the recent 2.5 release.

280 ded with drier positive PNA-like conditions, culminating in the staggered abandonment of many major N

281 to a remarkable degree in the last 5 years, culminating in the successful correction of a cardiomyop

282 of this strategy was successfully realized, culminating in the synthesis of oridamycin A and oridamy

283 The studies culminating in the synthesis of two large subunits of ta

284 velopment of an efficient masticatory system-culminating in the tribosphenic apparatus-allowed early

285 al, NMR, kinetic and theoretical approaches, culminating in the unprecedented detection and quantific

286 ology, and platelet production and function, culminating in thrombocytopenia and platelet dysfunction

287 1 +/- 0.4 Tg CH(4) yr(-1) from 2010 to 2015, culminating in total anthropogenic and natural emissions

288 RP load were not always mutually beneficial, culminating in trade-offs among multiple Lake Erie phosp

289 fferentiation at sites of tissue injury that culminates in transformed barriers composed of scar and

290 ite insensitivity to cardiac glycosides(16), culminating in triple mutant 'monarch flies' that were a

291 , and inhibited the dysfunctional phenotype, culminating in tumor growth inhibition.

292 This culminated in two tool molecules, 20 (GSK620) and 56 (GS

293 d cyclical and how its features interact and culminate in unsafe care.

294 ctivation of the Raf/MEK/ERK kinase cascade, culminating in upregulation of CDK1 with subsequent SAMH

295 Some viral infections culminate in very different outcomes in different indivi

296 Acute hepatitis C virus (HCV) infection culminates in viral persistence in the majority of cases

297 erepressing and sustaining its expression to culminate in virus production.

298 ons of calves latently infected with BoHV-1, culminating in virus shedding and transmission.

299 of salt and water into the intestinal lumen, culminating in watery diarrhea.

300 cell death, but also release toxic proteins culminating in widespread proteolysis, nucleolysis, and