ライフサイエンスコーパス: cumbersome

1 ll fusion mechanistic studies are especially cumbersome.

2 tion in the histopathology laboratories more cumbersome.

3 ion of the common and efficient reagents are cumbersome.

4 eedingly rare and methods to purify them are cumbersome.

5 -cell fusion mechanistic studies are notably cumbersome.

6 a new natural or synthetic inhibitor can be cumbersome.

7 parate databases makes information discovery cumbersome.

8 curve (PAP/AUC) is the gold standard but is cumbersome.

9 enic viruses or bacteria tend to be slow and cumbersome.

10 nal magnetic field (B), which is practically cumbersome.

11 modifications in living cells is complex and cumbersome.

12 ous agent and its use in plasmapheris is too cumbersome.

13 asurement of plasma C2 glucose enrichment is cumbersome.

14 s in a given enzyme preparation are slow and cumbersome.

15 detecting accelerated muscle proteolysis are cumbersome.

16 reassortment by more traditional methods is cumbersome.

17 assessing kidney function, is expensive and cumbersome.

18 luating this function are either invasive or cumbersome.

19 ids is well established, it is laborious and cumbersome.

20 lele states by allele sequencing is slow and cumbersome.

21 specificity and low sensitivity and are also cumbersome.

22 that sometimes are excessively intrusive and cumbersome.

23 nteractions, where genetic analysis is often cumbersome.

24 d genetic manipulations become difficult and cumbersome.

25 ime and makes exploration of this degeneracy cumbersome.

26 t, and the measurement process is relatively cumbersome.

27 collection of clinical data, which is often cumbersome.

28 resolution, making spectral assignment very cumbersome.

29 ng those data in downstream analyses remains cumbersome.

30 e to the allergen, but is time-consuming and cumbersome.

31 engineering, but library construction can be cumbersome.

32 Segmentation can be cumbersome; a fast, easy, and robust method is needed.

33 ic, requires many washing steps, making it a cumbersome addition to a high throughput workflow.

34 biomedical applicability is hindered by its cumbersome administration, since NO is unstable especial

35 rdous chemicals were hindered by complex and cumbersome administrative burdens, data limitations, vul

36 ide a more rapid and possibly less toxic and cumbersome alternative to traditional G-CSF-based mobili

37 rrent methods used to titer many viruses are cumbersome and are not amenable to handling large number

38 External air connectors can be cumbersome and are real-estate intensive.

39 Human clinical studies are cumbersome and are thwarted by the extent of investigati

40 s evolved into an expensive, time consuming, cumbersome and bureaucratic process involving multiple i

41 teractions since labeling small molecules is cumbersome and can affect binding.

42 otoresponsive, which makes their preparation cumbersome and can markedly hamper their performance.

43 to identify DNaseI hypersensitive sites are cumbersome and can only be applied to short stretches of

44 his is promising, but ex-vivo approaches are cumbersome and challenging to translate clinically.

45 teraction (GxE) meta-analysis studies can be cumbersome and challenging.

46 sequences to depict the fistula in detail is cumbersome and confusing for the clinicians to interpret

47 rrelated with the angle measured on the more cumbersome and costly full-limb radiograph.

48 irus vaccine could abolish the need for this cumbersome and costly process and would also enhance our

49 l function has traditionally been limited by cumbersome and costly techniques and the involvement of

50 In vitro mutagenesis is cumbersome and costly: probing all residues in a protein

51 from radiolabeled inositol, making the assay cumbersome and difficult to automate.

52 gs; however, in vitro manipulation of DCs is cumbersome and difficult to control, resulting in vaccin

53 eas calculations of hot carrier dynamics are cumbersome and dominated by empirical approaches.

54 in a case-by-case fashion, but this becomes cumbersome and error prone if genes show a huge abundanc

55 cardiography), beacuse current platforms are cumbersome and expensive for individual physician use.

56 lly, the preoperative workup is logistically cumbersome and expensive given the need for separate car

57 Cancer vaccines typically depend on cumbersome and expensive manipulation of cells in the la

58 t femtomoles of target DNA without employing cumbersome and expensive optics, light sources, or photo

59 mobility models today depend on detailed but cumbersome and expensive travel surveys for their calibr

60 e not only time consuming, but they are also cumbersome and expensive.

61 Execution of such advice can be cumbersome and expensive.

62 ut binding assays, which have replaced often cumbersome and highly technical functional assays.

63 ics of pair-wise screening has resulted in a cumbersome and incomplete application of this method to

64 and by autoradiography using film, which is cumbersome and increases the cost of generating the radi

65 Unfortunately, cumbersome and inefficient radioiodination procedures ha

66 (GM) counter, although this procedure can be cumbersome and inexact.

67 Traditional serotyping methods are cumbersome and insufficient for detecting multiple serot

68 e the older DNA hydrolysis protocol which is cumbersome and labor intensive, this new protocol is ide

69 dentification of pairing antibodies is often cumbersome and labor-intensive even with the use of desi

70 However, current analysis methods are cumbersome and lack the use of the volumetric data from

71 imulations, these models are computationally cumbersome and limit analytical insight into the mechani

72 nt bioassay used to measure BioA activity is cumbersome and low throughput.

73 formed using synthetic constructs, making it cumbersome and non-physiological.

74 ng sites of transcription factors tend to be cumbersome and not adaptable to high throughput.

75 Because pulsed Doppler is cumbersome and often inappropriate for color flow comput

76 ctrometry, but implementation often involves cumbersome and potentially dangerous configurations.

77 sis to be performed without the need for the cumbersome and problematic enhanced sensitivity cell.

78 ases, but the standard method is protracted, cumbersome and prone to error.

79 near range from individual kinetic traces is cumbersome and prone to user error and bias.

80 rrent system of GME financing is complex and cumbersome and relies almost exclusively on government s

81 Conventional methods for determining HMF are cumbersome and require expensive equipment or hazardous

82 Both methods are cumbersome and require the use of expensive reagents.

83 ence of genomic DNA of analogous sequence is cumbersome and requires implementation of critical contr

84 aria model system Plasmodium yoelii has been cumbersome and requires terminal procedures.

85 on in high dimensions is often very complex, cumbersome and slow.

86 ple models and hyperparameters, which can be cumbersome and slow.

87 high performance liquid chromatography, are cumbersome and slow.

88 serum samples that were required by the more cumbersome and subjective IFA testing to <20%.

89 thesis of specific bioactive HS structures a cumbersome and tedious undertaking that requires laborio

90 hnical aspects of this procedure become less cumbersome and the patient population increases, it is v

91 Currently available indexes are cumbersome and therefore seldom used.

92 photoreceptor activity in living humans was cumbersome and time consuming.

93 in structures, these tools are generally too cumbersome and time-consuming for examining multiple sup

94 'shopping around' using different methods: a cumbersome and time-consuming practice.

95 The cumbersome and time-consuming process of generating new

96 the quantitative analysis of IAA has been a cumbersome and time-consuming process that does not lend

97 f knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem

98 However, these existing methods are cumbersome and time-consuming, and none measures all of

99 gular visits to outpatient clinics, which is cumbersome and time-consuming, decreasing patient qualit

100 completing the required design steps can be cumbersome and time-consuming.

101 ough conventional microbiological methods is cumbersome and time-consuming.

102 ever, literature syntheses of the ligand are cumbersome and typically lead to low yields.

103 s, a situation that can become prohibitively cumbersome and which can defeat the purpose of linking m

104 ave led to systems that are often expensive, cumbersome, and challenging to operate, confining many d

105 to completion we are left with inefficient, cumbersome, and costly macroscale processes and supporti

106 ore sensitive than culture, more rapid, less cumbersome, and more cost-effective than the available P

107 intravenous chemotherapy regimens are toxic, cumbersome, and negatively affect patients' quality of l

108 basophil histamine release, but the assay is cumbersome, and no one has studied the effects of immuno

109 id chromatography, which are time-consuming, cumbersome, and sometimes inaccurate due to the incomple

110 for identifying these organisms are slow and cumbersome, and there is increasing need for more rapid

111 assays are immunologically based and require cumbersome antibody immobilization chemistries, thereby

112 alues equal to those of the more technically cumbersome antigenemia assay.

113 e ESwab method is a more accessible and less cumbersome approach to corneal culturing for ophthalmolo

114 sequences to tag an endogenous gene is still cumbersome as it requires the synthesis or cloning of ho

115 mation is highly condensed, these views grow cumbersome as larger numbers of genomes are added.

116 uction, without the need for the common, but cumbersome, azeotropic drying of (18)F, can now be accom

117 oteins enrichment from biological samples is cumbersome because of their low abundance.

118 for in vivo evaluation of antiandrogens are cumbersome because they rely on physiologic end points,

119 delivering this combination of molecules is cumbersome, because of the opposing supramolecular host

120 ication of this preexisting variation may be cumbersome, because potentially beneficial alleles are t

121 Ex vivo techniques are more cumbersome but safer, because all genetic manipulations

122 ression of the construct without the need of cumbersome chemical labeling.

123 SAL stereoisomers on a chiral column without cumbersome chiral derivatization to unstable SAL diaster

124 olographic rendering can be achieved without cumbersome circuitry and with only a single transducer,

125 rge fragments of DNA and numerous, and often cumbersome, cloning steps.

126 tem nucleus defined by genetic lineage and a cumbersome combination of markers.

127 le user orientation and its prerequisite and cumbersome combination of mouse and keyboard for navigat

128 in mammalian cells using current methods is cumbersome, complex, or expensive.

129 eby reducing the need for time-consuming and cumbersome confirmatory plaque-reduction neutralization

130 First-generation devices consisted of large, cumbersome consoles requiring patient immobilization and

131 However, it is cumbersome, costly, and associated with considerable tox

132 ed for organizing and interpreting otherwise cumbersome data sets when extremely large numbers of ful

133 usually tackled by implementing unattractive cumbersome designs.

134 method for determining the activity has been cumbersome due to the use of a site-specifically (3)H-la

135 ce of supportive materials, making them less cumbersome during locomotion.

136 es for electrochemical detection without any cumbersome electrode surface functionalization procedure

137 atomic absorption spectrometry but with less cumbersome equipment and freedom from calibration.

138 njection volumes required make this approach cumbersome, especially for developmental studies.

139 Cumbersome, expensive and time consuming detection techn

140 sor is fully electronic and requires neither cumbersome, expensive optics nor high voltage power supp

141 fucosylation, such strategies are often too cumbersome, expensive, and time-consuming for routine N-

142 rface receptors and their ligands is often a cumbersome, expensive, and time-consuming process that l

143 cted great attention by mitigating otherwise cumbersome experimental implementation constraints.

144 ge part to the requirement for prohibitively cumbersome experimental procedures and daunting analytic

145 s to provide a ready alternative to the more cumbersome femtomolar electrochemical assays described t

146 PA) to replace the more costly, wasteful and cumbersome filter binding assay and demonstrate its util

147 However, LC-MS/MS proved cumbersome for analyzing multiple samples because it req

148 This kind of analysis is especially cumbersome for complex samples with hundreds to thousand

149 logy remains insufficiently accurate and too cumbersome for continuous ICP monitoring.

150 arations has been well characterized, but is cumbersome for drug discovery.

151 ) allow for linguistic communication but are cumbersome for expressing emotions.

152 As data visualization techniques become cumbersome for higher dimensions and unconvincing when t

153 A is impractical, variably reproducible, and cumbersome for large epidemiologic studies and for clini

154 However, the determination of log P is cumbersome for non-UV-active compounds.

155 Wired technology can be cumbersome for patient monitoring and can restrict the b

156 rologously express membrane proteins, can be cumbersome for screening and expression of multiple cons

157 based assay is useful, but this technique is cumbersome for TDP2 inhibitor screening.

158 ion, fluorescence labeling and mutations are cumbersome for the whole ribosome but readily applicable

159 eing comparable to a well-optimized but more cumbersome gas chromatography-mass spectrometry (GC-MS)

160 ient cell factories has been impaired by the cumbersome genetic tools that are currently available fo

161 e to DNA sequencing or other, more costly or cumbersome genotyping approaches.

162 A) because of significantly lower cost, less cumbersome handling, smaller delivery catheters, and sup

163 plotypes have not been determined because of cumbersome haplotyping workflows that require fractions

164 h privileged pharmacological structures, are cumbersome, hazardous or, in some cases, unavailable.

165 Standard traditional techniques are slow and cumbersome, highlighting the pressing need for evoking a

166 wide temperature range without the need for cumbersome humidification and pressurization.

167 are inoperable above 100 degrees C, require cumbersome humidification systems, and suffer from fuel

168 nalyzing associated loci and variants can be cumbersome if data is not given in a form amenable to pa

169 urface of microtiter wells that replaces the cumbersome immunoprecipitation method, (iii) a 96-well p

170 cro-fabrication techniques have proven to be cumbersome in building cost-effective micro-devices, thu

171 ers, because achievement of hyperemia can be cumbersome in daily clinical practice.

172 studying regulatory interactions, but remain cumbersome in most model organisms.

173 complex genetic interaction analysis remains cumbersome in this diploid pathogen.

174 imited numbers of animals; alternative, less cumbersome in vivo models are desirable.

175 owever, this physiological evaluation can be cumbersome, inaccessible and costly.

176 rent methods of monitoring breathing require cumbersome, inconvenient, and often expensive devices; t

177 Advancing beyond cumbersome, inefficient, and often manual removal of mar

178 ethods used to detect mitophagy in vivo were cumbersome, insensitive and difficult to quantify.

179 brary bead processors eliminates potentially cumbersome instrumentation engineering challenges and is

180 fliximab than ciclosporin, mainly due to the cumbersome intravenous regimen required for ciclosporin.

181 is process has been hampered by the need for cumbersome isolation of intact genomes before transfer.

182 rent taxonomic practice continues to rely on cumbersome journal publications for the description of n

183 Slow and cumbersome laboratory diagnostics for Mycobacterium tube

184 methods for BPA exposure assessment rely on cumbersome laboratory instrumentation with high capital

185 ng and bioinformatics turned the complex and cumbersome library preparation to the bottleneck in term

186 polar to polar solvents without resorting to cumbersome ligand exchange procedures.

187 , current assays for DNA-protein adducts are cumbersome, limiting both mechanistic studies and transl

188 No cumbersome liquid junction based reference element is ut

189 ng magnetic-device elements without applying cumbersome magnetic fields.

190 ively complex, requiring the user to perform cumbersome maneuvers and time-consuming image manipulati

191 not to be confined to the tedious growth and cumbersome manipulation of molecular crystals-which gene

192 res that can be used to classify tissue is a cumbersome manual process which limits this technology f

193 lyze cytosine-5 methylation patterns require cumbersome manual techniques that employ gel electrophor

194 gy density is relatively sluggish due to the cumbersome material storage.

195 nt volumes and regurgitant fractions without cumbersome measurements.

196 sum) in pears does not necessarily require a cumbersome method involving cleavage to DMA.

197 etion defects observed previously using more cumbersome methodology.

198 been partially alleviated by the use of more cumbersome methods such as three-dimensional confocal mi

199 ternatives to substitute for the traditional cumbersome methods.

200 les, such as aromatic amines, onto sluggish (cumbersome) Michael acceptors without any promoter or wo

201 ng remains a challenge, primarily due to the cumbersome, multi-step synthesis processes conventionall

202 In current form, however, FIAs can be cumbersome, multistep procedures and often lack versatil

203 programs has been limited by the lengthy and cumbersome nature of current chemotherapeutic regimens.

204 t leprosy are difficult to obtain due to the cumbersome nature of the conventional drug susceptibilit

205 However, such mixing can be cumbersome, non-robust, and wasteful of materials.

206 used in paraffin sections, thereby obviating cumbersome oil red O staining of frozen sections.

207 , these techniques are either experimentally cumbersome or applicable to a limited set of experimenta

208 Current GCPII in vitro activity assays are cumbersome or have limited sensitivity.

209 ormatics tools do not scale accordingly, are cumbersome, or require extensive support from bioinforma

210 avirus virion production has been limited to cumbersome organotypic cultures and mouse xenografts.

211 s in men, but until recently it has required cumbersome parenteral administration.

212 he first inhibitors studied were hampered by cumbersome pharmacokinetics and a general lack of potenc

213 is method provides a new alternative to more cumbersome plasmid- or PCR-based protein expression work

214 ity are limited, because existing assays are cumbersome, poorly sensitive, low throughput, and restri

215 luding limited cell sources and the need for cumbersome pre-processing steps (for example, isolation,

216 on overexpressed genetically encoded tags or cumbersome probes can significantly alter the native sta

217 the decay process in these systems is a very cumbersome problem, either because of very complicated o

218 less, they often take around 6 h and require cumbersome procedures.

219 d clinical task demand customized tools, the cumbersome process of making problem-specific choices ha

220 ed to create mutations, gene targeting, is a cumbersome process.

221 apping as gapped alignment, which results in cumbersome processing times and a biased sampling of STR

222 poor access, frequent adverse reactions, and cumbersome production/purification.

223 dendritic cell-based vaccination methods are cumbersome, promising results from clinical trials in pa

224 RNA and DNA tracking would avoid the use of cumbersome protein fusion labels and minimize structural

225 d disease state, are typically monitored via cumbersome, reagent-intensive assays that require relati

226 requires multiple ligation steps and remains cumbersome relative to more conventional deep-sequencing

227 ve transmission electronic microscopy, often cumbersome, remains as the 'gold standard' for dispersio

228 olicy can lack transparency and is sometimes cumbersome, requiring the intervention of a Senior Ethic

229 The need for cumbersome RNA purification is circumvented in our assay

230 e directly detected simultaneously, avoiding cumbersome sample preparation procedures in conventional

231 e substantially context dependent, requiring cumbersome screening to identify the optimal site for st

232 mary procedure, which involves a lengthy and cumbersome second-order (in wave-amplitude) calculation

233 Conventional approaches often rely on cumbersome, semi-quantitative amplification of target DN

234 ecedents were never applied by others due to cumbersome setups and limited scope.

235 e performed conveniently at home, and avoids cumbersome shipping and storage procedures.

236 still involve impractical solutions such as cumbersome signal calibration processes and substantial

237 ipotent cells (iPSCs) into neurons are often cumbersome, slow, and variable.

238 ns tested, thus eliminating the need for the cumbersome spheroplast-proteinase K method for topology

239 With this approach, the cumbersome step of 18C purification has been eliminated.

240 This would bypass the cumbersome step of having to evolve mutant synthetases a

241 e one-pot synthesis procedure eliminates the cumbersome steps of protecting/deprotecting amino or hyd

242 Most gene expression methods often involve cumbersome steps or use expensive facilities.

243 ect method uses the whole AH suspension, the cumbersome steps used by traditional methods are not req

244 nal methods which involve time-consuming and cumbersome strip comparisons obtained with series of tri

245 ltiplexed Western blots are possible without cumbersome stripping and reprobing steps.

246 ers are complex and often require costly and cumbersome structural components to support system weigh

247 Based on absence of cumbersome surface immobilization and wash steps for car

248 limited due to their relative insolubility, cumbersome synthesis/purification, toxic side effects, a

249 eliable and fit-for-purpose models remains a cumbersome task due to the inherent complexity of biolog

250 typically done by writing custom code, is a cumbersome task that can be streamlined and standardized

251 ctrochemical microscopy (SECM) is a slow and cumbersome task that often results in untimely electrode

252 We wanted to determine a more rapid and less cumbersome technique to supplement this method for deter

253 The method is simple and avoids the use of cumbersome techniques associated with enzymatic treatmen

254 rmore, it is a far more rapid assay and less cumbersome than western blotting, lending itself more re

255 As filters are cumbersome, there is interest in using disks instead of

256 ed accurate GFR methodology is expensive and cumbersome; therefore, estimates of GFR based on serum c

257 ugh the last aromatization step proved to be cumbersome, this work unfolds a unique route to access i

258 omise for B-cell malignancies, production is cumbersome; thus, targeting a common antigen on malignan

259 However, these methods are cumbersome, time consuming and cost-prohibitive.

260 ost methods used to measure BER activity are cumbersome, time consuming and, for the most part, only

261 ration of ion-selective electrodes (ISEs) is cumbersome, time-consuming, and constitutes a significan

262 for recognition of TGs, among them, most are cumbersome, time-consuming, require sample pre-treatment

263 responsive measure of disability, but it is cumbersome to administer and has a limited content valid

264 enge, but existing frameworks are either too cumbersome to apply genome-wide or unable to model a num

265 e contribution to mortality risk but are too cumbersome to be readily applied in clinical practice.

266 reconstructions are powerful, they are still cumbersome to build and, because of the complexity of me

267 ential for ambiguous gene symbols, making it cumbersome to capture the "correct" set of genes.

268 ion can act, yet fine-scale linkage maps are cumbersome to construct.

269 ever, with currently available vectors it is cumbersome to create multiple, stable, unmarked chromoso

270 s (NO/nucleophile adducts-NONOates) are less cumbersome to deliver and may offer clinical advantage c

271 Although it is extremely expensive and cumbersome to deploy large-scale radiofrequency phased a

272 However, it is cumbersome to identify functional motifs within enhancer

273 In the past, these methods have been cumbersome to implement and modify.

274 However, it is cumbersome to implement clinically given the large numbe

275 ion is central to cellular bioenergetics but cumbersome to measure.

276 d liver diseases in the United States may be cumbersome to obtain because they are scattered in multi

277 r do not facilitate biofilm formation or are cumbersome to operate, need large reagent volumes, and a

278 -resolution separations, such formats can be cumbersome to parallelize for single-cell analysis.

279 With existing approaches, it is cumbersome to perform multiplexed blots in which several

280 ite Sanger sequencing is not only costly and cumbersome to perform, it is inaccurate because of relat

281 the bromo and fluoro analogues that are more cumbersome to prepare or are not readily available.

282 unreported tetracycline derivatives that are cumbersome to prepare through traditional methods.

283 l tricarbonyl compounds, which are otherwise cumbersome to prepare.

284 o far have employed optical systems that are cumbersome to scale to even a few tens of qubits.

285 ts become increasingly abundant, making them cumbersome to store and analyze on local servers.

286 curves and engineering overhead, making them cumbersome to use for everyday data exploration and prot

287 However, these models remain expensive and cumbersome to use for large-scale preclinical drug testi

288 inadequate display of insertions and can be cumbersome to use on large datasets.

289 ns of predictive rules are more accurate but cumbersome to use, and therefore of limited clinical use

290 s in taking medication in the 1960s but were cumbersome to use.

291 adhere to all three are hard to develop and cumbersome to work with, often resulting in sacrificing

292 hindered by increased genomic complexity and cumbersome transgenic assays.

293 easuring the degree of lung inflammation and cumbersome treatment protocols.

294 cing side effects which results in extremely cumbersome treatment schedules reducing patient's compli

295 tethered to bulky control systems, and have cumbersome user interfaces, which all render commerciali

296 and adenocarcinoma (ADCA) of the lung can be cumbersome using established methods.

297 tudies of RNA-protein interactions are quite cumbersome using traditional methods.

298 ially, researchers often elect to forego the cumbersome verification step, potentially leading to rep

299 he process of loading high-density gels less cumbersome while the associated time and errors are redu

300 ixture of an asymmetric reduction eliminates cumbersome work-up protocols and minimizes analysis time