ライフサイエンスコーパス: curare

1 e central command influence) using Norcuron (curare).

2 ta (deltaTrp-57) subunits that interact with curare.

3 ine < nicotine < acetylcholine < carbachol < curare.

4 species differences in circuit responses to curare.

5 ocked by alpha-bungarotoxin (0.2 microM) and curare (1 microM).

6 gesting that this residue may be involved in curare-5HT3R interactions.

7 e-field areas, we have exposed the retina to curare, a nicotinic cholinergic antagonist, because spon

8 Within this region of the receptor, curare affinity is reduced by substitution only at Trp-8

9 mitted the first successful entry toward the curare alkaloids (+/-)-tubocurine and (+/-)-curine.

10 in seconds after contact and were blocked by curare and alpha-bungarotoxin, but not by TTX and Cd(2+)

11 ependent synaptic transmission is blocked by curare and by alpha-bungarotoxin (alpha-BTX).

12 The nicotinic antagonists curare and dihydro-beta-erythroidine also up-regulated a

13 he affinity of the 5HT3R for the antagonists curare and granisetron but has little effect on the affi

14 Exposure to cholinergic antagonists, curare and hexamethonium bromide, which block chemical n

15 In Melibe, curare application caused the burst duration of the swim

16 tagonist [alpha-bungarotoxin (alpha-BTX) and curare] binding, these results indicate that mAbs could

17 In both species, replacing the curare-blocked Si3 synapses with artificial synapses usi

18 Application of curare (d-tubocurarine) selectively blocked the Si3 syna

19 structural level, we studied binding of the curare derivatives d-tubocurarine (d-TC) and metocurine

20 Additionally, decrement-inducing curare dose and AChR content in the tibialis anterior (T

21 pattern to lengthen, whereas in Dendronotus, curare halted bursting altogether.

22 The competitive antagonist d-tubocurarine (curare) has greater potency at mouse than at human 5-hyd

23 mutant receptor, H-K195E,V202I, had the same curare IC50 (133.8 +/- 6.38 nM) as that of the human rec

24 contribute to curare potency, given that the curare IC50's (concentration of drug that produces 50% i

25 (H-K195E or H-V202I) had significantly lower curare IC50's than that of the human receptor.

26 The curare-impaired bursting in Dendronotus was also restore

27 eceptive fields of ganglion cells exposed to curare in hatchlings reared in normal light and dark cyc

28 aneous bursting was chronically blocked with curare in hatchlings, dark-induced expansion of receptiv

29 nanomolar concentrations of d-tubocurarine (curare) in a competitive fashion.

30 their sedative and hypotensive effect, their curare-like activity and structural framework have made

31 title compounds (19, 20ab, and 26) displayed curare-like effects of ultrashort duration in rhesus mon

32 at can be further enhanced by treatment with curare or alpha-BTX, suggesting that muscle paralysis ma

33 line receptor (nAChR)-blocking agents [e.g., curare or alpha-bungarotoxin (alpha-BTX)] prevents the d

34 ke a significant contribution in determining curare potency at the 5-HT3A receptor.

35 significant role in conferring interspecies curare potency differences.

36 ata suggest that loops C and F contribute to curare potency, given that the curare IC50's (concentrat

37 [(3)H]Curare preferentially binds the alpha/gamma interface.

38 nstrate that blocking synaptic activity with curare reduces synaptic neuregulin expression in a dose-

39 approximately 30 degrees degree tilt of the curare scaffold within the binding pocket.

40 This blocking mechanism was tested using curare to demonstrate the open channel nature of the blo

41 Curare was released from Elvax, a slow-release polymer t