ライフサイエンスコーパス: cyclic nucleotide

1 ate bonds on different substrates, including cyclic nucleotides.

2 classic HCN channels, HCNL1 is not gated by cyclic nucleotides.

3 e active conformation differed for the three cyclic nucleotides.

4 rs and open in response to direct binding of cyclic nucleotides.

5 d is controlled by intracellular pH, but not cyclic nucleotides.

6 a model system consisting of nucleotides and cyclic nucleotides.

7 o phosphodiesterases involved in cleavage of cyclic nucleotides.

8 (MSNs) with low micromolar affinity for both cyclic nucleotides.

9 ulation of cell-signaling pathways involving cyclic nucleotides.

10 Reduced levels of the myelin protein 2'-3'-cyclic nucleotide 3'-phosphodiesterase (CNP) are associa

11 esponse to energy depletion, and renal 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) metaboli

12 In cells lacking 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase; an enzym

13 rotein, myelin proteolipid protein, and 2'3'-cyclic nucleotide 3'-phosphodiesterase compared with tho

14 vated form of Akt under control of the 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter, exhibit

15 roRNAs (miRNAs) play in remyelination, 2',3'-cyclic-nucleotide 3'-phosphodiesterase-EGFP(+) mice were

16 Swiss 3T3 cells and assessed the ability of cyclic nucleotide analogs to modulate the activity of Ep

17 des, as well as several derivatives, namely, cyclic nucleotides and dinucleotides, dinucleoside 5',5'

18 hlighted the importance of acutely regulated cyclic nucleotides and their effectors in the control of

19 Since C5a orthologs efflux cyclic nucleotides, and cAMP-dependent protein kinase (S

20 odulators of transcription factors, kinases, cyclic nucleotides, and G protein-coupled receptors.

21 The actions of cyclic nucleotides are generally mediated by binding of

22 Cyclic nucleotides are increasingly implicated in host-p

23 Cyclic nucleotides are second messengers that regulate c

24 Cyclic nucleotides are vital in SMC proliferation and mi

25 esterases (PDEs), enzymes that degrade 3',5'-cyclic nucleotides, are being pursued as therapeutic tar

26 ants apparently do not make extensive use of cyclic-nucleotide-based signalling.

27 symmetry caused by the absence of the second cyclic nucleotide binding (CNB) domain and the J-domain

28 Proteins with cyclic nucleotide binding and GAF domains can be identif

29 directly bind cAMP through their cytoplasmic cyclic nucleotide binding domain (CNBD), thus playing a

30 s of cAMP binding affinity to the N-terminal cyclic nucleotide binding domain and allosteric activati

31 -binding domain (CaMBD) overlapping with the cyclic nucleotide binding domain of plant CNGCs.

32 ing of cyclic adenosine monophosphate to the cyclic nucleotide binding domain of the bacterial potass

33 six transmembrane domains and a cytoplasmic cyclic nucleotide binding domain.

34 activated by the binding of cAMPs to the two cyclic nucleotide binding domains (CBDs), A and B, on ea

35 terminus contains a region with homology to cyclic nucleotide binding domains (cNBHD), which is dire

36 ain and a C-terminal domain with homology to cyclic nucleotide binding domains (referred to as the CN

37 ivity between multiple binding events in the cyclic nucleotide binding domains of HCN pacemaker chann

38 of cAMP to conserved and well characterized cyclic nucleotide binding domains or structurally distin

39 Although cyclic nucleotide binding has been shown to promote CNG

40 that another parasite protein with putative cyclic nucleotide binding sites, Plasmodium falciparum E

41 ker, a domain that is essential for coupling cyclic nucleotide binding to channel opening.

42 couples conformational changes triggered by cyclic nucleotide binding to the gate.

43 hysiological roles by opening in response to cyclic nucleotides binding to a specialized cyclic nucle

44 membrane binding required the high-affinity cyclic nucleotide-binding (CNB) and Ras association doma

45 Cyclic nucleotide-binding (CNB) domains allosterically r

46 compounds that interact with the regulatory cyclic nucleotide-binding domain (CNB) of the cAMP senso

47 dent gating is mediated by the intracellular cyclic nucleotide-binding domain (CNBD) connected to the

48 Binding of cAMP to the cyclic nucleotide-binding domain (CNBD) facilitates chan

49 cAMP binds to a conserved intracellular cyclic nucleotide-binding domain (CNBD) in the channel,

50 rized by the presence of a carboxyl-terminal cyclic nucleotide-binding domain (CNBD) that connects to

51 ic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD), which is connec

52 channels, TRIP8b also binds directly to the cyclic nucleotide-binding domain (CNBD).

53 elements, including a C-linker region and a cyclic nucleotide-binding domain (CNBD).

54 cidate the conformational ensembles of PKA's cyclic nucleotide-binding domain A for the cAMP-free (ap

55 signal through key structural motifs in the cyclic nucleotide-binding domain and explore the role of

56 s structural element in synergy with the HCN cyclic nucleotide-binding domain and specific interactio

57 In this report, we found that the cyclic nucleotide-binding domain and the C terminus of t

58 Although the C-terminal cyclic nucleotide-binding domain B of PKG binds cGMP wit

59 apo, cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B.

60 s conformation of a conserved proline in the cyclic nucleotide-binding domain determines the activati

61 Here using the conserved cyclic nucleotide-binding domain of protein kinase A's (

62 (TM) domain of a bacterial channel, and the cyclic nucleotide-binding domain of the mouse HCN2 chann

63 rrangements within the linker and N-terminal cyclic nucleotide-binding domain of the RIIbeta homodime

64 We show that TRIP8b binds the HCN cyclic nucleotide-binding domain through a 37-residue do

65 as disrupted by mutation within its putative cyclic nucleotide-binding domain within PDZ-GEF1.

66 cyclic nucleotides binding to a specialized cyclic nucleotide-binding domain.

67 T) to directly observe binding at individual cyclic nucleotide-binding domains (CNBDs) from human pac

68 autoinhibitory segment (AIS), four predicted cyclic nucleotide-binding domains (CNBs), and a kinase d

69 opening via a direct interaction between the cyclic nucleotide-binding domains and voltage sensors.

70 Upon cAMP binding, the cyclic nucleotide-binding domains move vertically toward

71 characterized potassium channel KcsA and the cyclic nucleotide-binding domains of the prokaryotic cyc

72 ial, and their gating regulated by cytosolic cyclic nucleotide-binding domains.

73 Sim (PAS) domains, as well as the C-terminal cyclic nucleotide-binding homology (cNBH) domain.

74 linker and two in the adjacent region of the cyclic nucleotide-binding homology domain, can fully acc

75 unctions, but the mechanisms that enable the cyclic nucleotide-binding signal to regulate distant dom

76 arboxy-terminal linker connecting S6 and the cyclic-nucleotide-binding domain interacts directly with

77 Synthesis of the cyclic nucleotide c-di-AMP has been reported for a numbe

78 Cyclic nucleotide cAMP is a ubiquitous secondary messeng

79 They open in response to direct binding of cyclic nucleotide (cAMP or cGMP) to a cytoplasmic region

80 CNG channels open upon direct binding of cyclic nucleotides (cAMP and/or cGMP), but the allosteri

81 PGI2 and NO effects are mediated by cyclic nucleotides, cAMP- and cGMP-dependent protein kin

82 processes, here we investigated whether the cyclic nucleotide cGMP influences Abeta levels and funct

83 m significantly exceeded that of the natural cyclic nucleotides cGMP or cAMP.

84 Cytosolic Ca(2+) elevations, cyclic nucleotide (cGMP)-activated Ca(2+) channels, and

85 egation, a novel hyperpolarization-activated cyclic nucleotide channel 4 (HCN4)-G482R mutation and a

86 clic nucleotide-gated (CNG) channels convert cyclic nucleotide (CN) binding and unbinding into electr

87 s associated with impaired nitric oxide (NO)-cyclic nucleotide (CN)-coupled intracellular calcium (Ca

88 Here, we identify dysregulation of cyclic-nucleotide (CN)-linked neuronal Ca(2+) channel ac

89 and is further facilitated by intracellular cyclic nucleotides (cNMPs).

90 ar effectors, compartmentalized signaling of cyclic nucleotides confers specificity to extracellular

91 Emerging evidence also suggests that cyclic nucleotide coupled phosphodiesterases (PDEs) play

92 levels are tightly controlled by a family of cyclic nucleotide degrading enzymes, the PDEs.

93 alters both the cell surface expression and cyclic nucleotide dependence of these channels.

94 s a competitive antagonist that inhibits the cyclic-nucleotide dependence of HCN channels.

95 phorylation of the GluA1 subunit of AMPAR by cyclic nucleotide-dependent kinases, making cyclic nucle

96 we tailored a series of 18 novel fluorescent cyclic nucleotide derivatives by attaching 6 different d

97 monstrated to be effective, each immobilized cyclic nucleotide did not discriminate in the enrichment

98 e can travel across many layers of cells via cyclic nucleotide diffusion through gap junctions could

99 cells, fluid shear stress or the addition of cyclic nucleotides enhanced AQP1 surface expression and

100 Although ABCC4 is an important cyclic nucleotide exporter, red blood cells from ABCC4nu

101 my perceived role in discoveries made in the cyclic nucleotide field that culminated in the advent of

102 phosphorylation of its target, the beta-type cyclic nucleotide gated (CNG) channel subunit, TAX-2, wa

103 n channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the correspondin

104 vasculature- and plasma membrane-localized, CYCLIC NUCLEOTIDE GATED CHANNEL19 (CNGC19), which activa

105 ut independent of transducin that sensitizes cyclic nucleotide gated channels to cGMP and causes phot

106 a consequence of the direct activation of a cyclic nucleotide gated current.

107 Cyclic nucleotide-gated (CNG) and hyperpolarization-acti

108 ia during the response through the olfactory cyclic nucleotide-gated (CNG) channel and stimulates a d

109 In contrast, the cyclic nucleotide-gated (CNG) channel inhibitor l-cis-di

110 studies implicate both Brugia osm-9 and the cyclic nucleotide-gated (CNG) channel subunit tax-4 in l

111 proteins, adenylate cyclase III (ACIII), and cyclic nucleotide-gated (CNG) channel, as well as disrup

112 ular OSNs, odorants elicit activation of the cyclic nucleotide-gated (CNG) channel, leading to Ca2+ g

113 We found that cAMP activates cyclic nucleotide-gated (CNG) channels and thereby induc

114 Cyclic nucleotide-gated (CNG) channels are expressed in

115 Cyclic nucleotide-gated (CNG) channels convert cyclic nu

116 se was not mediated by adenylyl cyclase (AC)/cyclic nucleotide-gated (CNG) channels or by protein kin

117 Cone photoreceptor cyclic nucleotide-gated (CNG) channels play a pivotal ro

118 Photoreceptor cyclic nucleotide-gated (CNG) channels play a pivotal ro

119 Cyclic nucleotide-gated (CNG) channels produce the initi

120 ncoding CNGA3 subunits of cone photoreceptor cyclic nucleotide-gated (CNG) channels undergoes alterna

121 ivated cyclic nucleotide-modulated (HCN) and cyclic nucleotide-gated (CNG) channels, MloK1 lacks a C-

122 icantly disrupts the localization of the rod cyclic nucleotide-gated (Cng) channels, which accumulate

123 Cyclic nucleotide-gated (CNG) ion channels are essential

124 Cyclic nucleotide-gated (CNG) ion channels are nonselect

125 Cyclic nucleotide-gated (CNG) ion channels, despite a si

126 currents of both hyperpolarization-activated cyclic nucleotide-gated (HCN) and small conductance calc

127 cturally related hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassiu

128 he open state of hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels, which are

129 The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is a voltage-gated

130 nce of increased hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated inward re

131 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for

132 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are major regulat

133 Pacemaker hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are unique among

134 The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels belong to the sup

135 Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels contribute to cat

136 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control spontaneo

137 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels directly bind cAM

138 plasma membrane hyperpolarization-activated cyclic nucleotide-gated (HCN) channels enhanced presynap

139 distribution of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in human SAN has

140 mine whether the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in ICCs-DM were r

141 lanation is that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels open at less hype

142 tor (NMDAR) and hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels play in this noci

143 t Ih mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels plays an importan

144 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate excitabi

145 emonstrates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal

146 mory through the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that underlie the

147 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels underlie the cont

148 rmeation through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, and contributes

149 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, particularly tha

150 presence of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, the STA characte

151 sked whether the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which are activa

152 rmeation through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

153 hanism involving hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

154 ium channels and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

155 c attenuation of hyperpolarization-activated cyclic nucleotide-gated (HCN) current as the cause for i

156 Hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channels attenuate exc

157 Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels control neuro

158 Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an impor

159 sphate (cAMP) to hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels regulates the

160 ssory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels, alters both

161 The hyperpolarization-activated cyclic nucleotide-gated (HCN1) channels are predominantl

162 ce expression of hyperpolarization-activated cyclic nucleotide-gated 1 (HCN1) channels was also lower

163 Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels are critic

164 eptor for relaxin-3 (RXFP3) and a functional cyclic nucleotide-gated channel (CNGA), which suggests d

165 Cyclic nucleotide-gated channel (CNGC) family members me

166 supply is sufficient, two genes that encode cyclic nucleotide-gated channel (CNGC) proteins, CNGC2 a

167 assium-sensitive hyperpolarization-activated cyclic nucleotide-gated channel (HCN) conductance in the

168 kedly depends on hyperpolarization-activated cyclic nucleotide-gated channel (HCNC) activation.

169 mma (Prkcc), and hyperpolarization-activated cyclic nucleotide-gated channel 1 (Hcn1)) that were cons

170 The gene, hyperpolarization-activated cyclic nucleotide-gated channel 1 (Hcn1), regulates neur

171 ingle QTG, Hcn1 (hyperpolarization-activated cyclic nucleotide-gated channel 1), which has been impli

172 Here, we report that CYCLIC NUCLEOTIDE-GATED CHANNEL 14 (CNGC14) is essential

173 function of the hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) are decreased i

174 rk4 cell death suppressors, we revealed that cyclic nucleotide-gated channel 20 (CNGC20) functions as

175 noreactivity for hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) and the transcr

176 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4) locus of the mouse ge

177 oreactivity for hyperpolarization activated, cyclic nucleotide-gated channel 4, were located in the b

178 localization and trafficking process of rod cyclic nucleotide-gated channel alpha-subunit (CNGA1), a

179 Cone density in cone cyclic nucleotide-gated channel B subunit-deficient and

180 Further, cone cyclic nucleotide-gated channel B subunit-deficient mice

181 Mutations in cyclic nucleotide-gated channel beta 1 (CNGB1) cause app

182 cs analysis revealed the z13 receptor as the cyclic nucleotide-gated channel beta3, a sorting pathway

183 PSKR1 is coexpressed with the CYCLIC NUCLEOTIDE-GATED CHANNEL gene CNGC17.

184 rted for the hyperpolarization-activated and cyclic nucleotide-gated channel HCN2 in the family of so

185 mpartmentalization allows the confinement of cyclic nucleotide-gated channel in the PM, while prevent

186 interacted with hyperpolarization-activated cyclic nucleotide-gated channel proteins (HCN proteins)

187 s the photoreceptors LITE and GUR-3, and the cyclic nucleotide-gated channel subunit TAX-2.

188 lecules for CPK32 led to identification of a cyclic nucleotide-gated channel, CNGC18, as an interacti

189 ger of Gata6 induces loss of hyperpolarizing cyclic nucleotide-gated channel, subtype 4 staining in t

190 node with some retention of hyperpolarizing cyclic nucleotide-gated channel, subtype 4 staining in t

191 he DOES NOT MAKE INFECTIONS 1 (DMI1) and the cyclic nucleotide-gated channels (CNGC) 15s.

192 We report that pollen-tube-specific cyclic nucleotide-gated channels (CNGC18, CNGC8, and CNG

193 Cyclic nucleotide-gated channels (CNGCs) are nonspecific

194 augmentation of hyperpolarization-activated cyclic nucleotide-gated channels (Ih or HCN channels).

195 cAMP opens cyclic nucleotide-gated channels allowing a Ca(2+) influ

196 portant role for hyperpolarization-activated cyclic nucleotide-gated channels and the cAMP/protein ki

197 These cyclic nucleotide-gated channels are located at the nucl

198 permeable to Ca(2+) We demonstrate that the cyclic nucleotide-gated channels form a complex with the

199 Recent advances of plant cyclic nucleotide-gated channels give new insight into t

200 We show that three cyclic nucleotide-gated channels in Medicago truncatula

201 odulation in hyperpolarization-activated and cyclic nucleotide-gated channels that display voltage-de

202 sms proposed for hyperpolarization-activated cyclic nucleotide-gated channels(5), and may represent a

203 nd inner segment hyperpolarization-activated cyclic nucleotide-gated channels, and from ATP-dependent

204 II activation, cAMP increase, and opening of cyclic nucleotide-gated channels.

205 hat mouse cold-sensitive neurons express the cyclic nucleotide-gated ion channel CNGA3, and that mous

206 udies suggest a labyrinth of receptor kinase-cyclic nucleotide-gated ion channel connections mediates

207 n and vertical migrations required the TAX-4 cyclic nucleotide-gated ion channel in the AFD sensory n

208 rexpression of a hyperpolarization-activated cyclic nucleotide-gated ion channel rescues the muscle p

209 In sea urchin sperm, a cyclic nucleotide-gated K(+) channel (CNGK) mediates a c

210 animal HCN (for Hyperpolarization-activated, cyclic nucleotide-gated K(+)) channels as structure temp

211 and function of hyperpolarization-activated cyclic nucleotide-gated nonselective cation (HCN) channe

212 ), and cyclic nucleotide-modulated channels (cyclic nucleotide-gated or hyperpolarization-activated a

213 gnaling cascade that leads to the opening of cyclic-nucleotide-gated (CNG), nonselective cation chann

214 ically expressed hyperpolarization-activated cyclic-nucleotide-gated (HCN) and transient potassium ch

215 l neurons to show that hyperpolarization and cyclic-nucleotide-gated (HCN) channels are expressed in

216 Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels control electrica

217 ssed the role of hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels in altering hippo

218 AQP1 is a dual water and cyclic-nucleotide-gated cation channel located in lamell

219 icle electron cryo-microscopy structure of a cyclic-nucleotide-gated channel from Caenorhabditis eleg

220 ion permeation, gating and channelopathy of cyclic-nucleotide-gated channels and cyclic nucleotide m

221 Cyclic-nucleotide-gated channels are essential for visio

222 ning mediated by hyperpolarization-activated cyclic-nucleotide-gated nonspecific-cation channels.

223 al retrosplenial hyperpolarization-activated cyclic-nucleotide-gated potassium channel 1 (HCN1) pacem

224 liary subunit of hyperpolarization-activated cyclic nucleotide (HCN)-gated channels.

225 s to the CRISPR system, which also generates cyclic nucleotides in response to viral infection.

226 Binding of cyclic nucleotides increases the rate and extent of chan

227 r activities are controlled by intracellular cyclic nucleotides instead of transmembrane voltage.

228 c interplay between these enzymes, governing cyclic nucleotide levels and infection outcomes in virus

229 To maintain homeostasis, cyclic nucleotide levels are regulated by phosphodiester

230 ereas exchange protein activated directly by cyclic nucleotide/MAPK kinase, another cAMP downstream e

231 Eukaryotic cyclic nucleotide-modulated (CNM) ion channels perform v

232 unlike eukaryote hyperpolarization-activated cyclic nucleotide-modulated (HCN) and cyclic nucleotide-

233 Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetrameri

234 ide-gated or hyperpolarization-activated and cyclic nucleotide-modulated (HCN) channels).

235 The hyperpolarization-activated cyclic nucleotide-modulated (HCN) ion channels control r

236 NGA4:CNGB1b), or hyperpolarization-activated cyclic nucleotide-modulated (HCN2) channels.

237 ucleotide-binding domains of the prokaryotic cyclic nucleotide-modulated channel MloK1.

238 otein directly activated by cAMP (Epac), and cyclic nucleotide-modulated channels (cyclic nucleotide-

239 The hyperpolarization-activated and cyclic nucleotide-modulated ion channel (HCN) drives the

240 SthK, a cyclic nucleotide-modulated ion channel from Spirochaeta

241 binding thermodynamics of cAMP to an intact cyclic nucleotide-modulated ion channel using isothermal

242 understanding of the evolutionary origin of cyclic nucleotide-modulated ion channels and pave the wa

243 Cyclic nucleotide-modulated ion channels are important f

244 Cyclic nucleotide-modulated ion channels are molecular p

245 Cyclic nucleotide-modulated ion channels play crucial ro

246 However, cyclic nucleotide-modulated ion channels were usually ou

247 nformational changes in full-length MloK1, a cyclic nucleotide-modulated potassium channel from the b

248 athy of cyclic-nucleotide-gated channels and cyclic nucleotide modulation of related channels.

249 modulation of HCN4 by cAMP, i.e. the primary cyclic nucleotide modulator of HCN channels.

250 perazines in the case of proteins and 2', 3'-cyclic nucleotide monophosphates in the case of RNA.

251 er amino acids, fatty acids, prostaglandins, cyclic nucleotides, odorants, polyamines, and vitamins.

252 gesting that the physiological effect of the cyclic nucleotide on LTP and memory is dependent upon Ab

253 To study effects of cyclic nucleotides on energy homeostatic mechanisms, mic

254 probed the allosteric mechanism of different cyclic nucleotides on the CNBD and on channel gating.

255 e in the distribution and/or availability of cyclic nucleotides or ADP may interfere with platelet re

256 s increasing intracellular levels of cAMP by cyclic nucleotide PDE inhibition both suppresses the imm

257 the successful identification of novel 3',5'-cyclic nucleotide phosphodiesterase (PDE) inhibitors, co

258 apped direct interactions between a specific cyclic nucleotide phosphodiesterase (PDE8A) and a PKA re

259 The cyclic nucleotide phosphodiesterase 10A (PDE10) has been

260 Cyclic nucleotide phosphodiesterase 3A (PDE3) regulates

261 e were generated by targeted inactivation of cyclic nucleotide phosphodiesterase 3b (Pde3b) gene, whi

262 f hepatocytes with 991 increases the Vmax of cyclic nucleotide phosphodiesterase 4B (PDE4B) without a

263 In recent years, cyclic nucleotide phosphodiesterase type 4 (PDE4) has ar

264 urally distinct cGMP-specific and -regulated cyclic nucleotide phosphodiesterase, adenylyl cyclase, a

265 Cyclic nucleotide phosphodiesterases (PDE) break down cy

266 Here, we provide evidence that type 4 cyclic nucleotide phosphodiesterases (PDE4s) are critica

267 Specific functions for different cyclic nucleotide phosphodiesterases (PDEs) have not yet

268 cyclic nucleotide-dependent kinases, making cyclic nucleotide phosphodiesterases (PDEs) potential re

269 Cyclic nucleotide phosphodiesterases (PDEs), through deg

270 The striatum contains a rich variety of cyclic nucleotide phosphodiesterases (PDEs), which play

271 ration and migration, which are regulated by cyclic nucleotide phosphodiesterases (PDEs).

272 hodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascula

273 -gated (CNG) and hyperpolarization-activated cyclic nucleotide-regulated (HCN) ion channels play cruc

274 to be mediated by protein kinase A (PKA) and cyclic nucleotide-regulated ion channels.

275 This cyclic nucleotide regulates flagellar function and besid

276 namics of multiple distinct steps underlying cyclic nucleotide regulation: a slow initial binding ste

277 ase/PDE enzyme pair to dynamically control a cyclic nucleotide second messenger (i.e., cAMP) for the

278 Increasingly, cyclic nucleotide second messengers are implicated in an

279 Cyclic nucleotide second messengers are increasingly imp

280 o the density of hyperpolarization-activated cyclic nucleotide-sensitive currents (I (H)).

281 Hyperpolarization-activated, cyclic nucleotide-sensitive HCN4 channels are critical d

282 describe SAVED-a widespread, uncharacterized cyclic nucleotide sensor protein domain that activates c

283 Our results suggest that protons rather than cyclic nucleotides serve as cellular messengers in zebra

284 importance in cross-talk between calcium and cyclic nucleotide signaling (PDE1), control of cell prol

285 whether PDE2 inhibition modulates pulmonary cyclic nucleotide signaling and ameliorates experimental

286 cular mechanisms that allow local control of cyclic nucleotide signaling is essential for our underst

287 Cyclic nucleotide signaling is impaired in HD models, an

288 an optogenetics tool for the manipulation of cyclic nucleotide signaling pathways.

289 channel in TVs, links transmitter-initiated cyclic nucleotide signaling with Ca(2+)-dependent TV exo

290 roles of different PDEs in the regulation of cyclic nucleotide signaling.

291 latelets and was suggested to be a target of cyclic nucleotide signaling.

292 Our findings highlight the crucial role of cyclic nucleotide signalling in the conflict between vir

293 Cyclic nucleotide signalling is a major regulator of mal

294 nhanced transmission may arise from impaired cyclic nucleotide signalling, resulting from compromised

295 effect on the C-linker and render all three cyclic nucleotides similarly potent activators of the ch

296 wledge, this is the first observation of non-cyclic-nucleotide small molecules with agonist propertie

297 cleotide phosphodiesterases (PDE) break down cyclic nucleotides such as cAMP and cGMP, reducing the s

298 e end organ, and is coupled to impairment of cyclic nucleotide targeted pathways linked to abnormal i

299 They are gated by the binding of cyclic nucleotides to a conserved, intracellular cyclic

300 ach using competitive concentrations of free cyclic nucleotides to isolate each kinase and its second