ライフサイエンスコーパス: cyclic peptide

1 chemical ligation to synthesize the grafted cyclic peptide.

2 or the MVCB[8] complex, matching that of the cyclic peptide.

3 d the other one composed of an aptamer and a cyclic peptide.

4 inhibition of SPSB2-iNOS interactions by the cyclic peptide.

5 l products limited the yields of the desired cyclic peptide.

6 ing protein, and (iii) an ultrahigh-affinity cyclic peptide.

7 6 tryptophan, thereby forming a 20-membered cyclic peptide.

8 ids, and greatly simplified the synthesis of cyclic peptides.

9 the library, resulting in linear rather than cyclic peptides.

10 yanobactins to include tryptophan-prenylated cyclic peptides.

11 based method for synthesizing disulfide-rich cyclic peptides.

12 easured by NMR to identify exposed amides in cyclic peptides.

13 )-mediated deprotection for the synthesis of cyclic peptides.

14 ble biophysical properties of disulfide-rich cyclic peptides.

15 late affinity for matriptase over trypsin in cyclic peptides.

16 view of nanotubes derived from this class of cyclic peptides.

17 rough conjugation of (macro)molecules to the cyclic peptides.

18 ates to generate a library of highly diverse cyclic peptides.

19 mising antiviral activity observed for these cyclic peptides.

20 onable yields (56-74%) of all of the desired cyclic peptides.

21 are all notable pharmacologically important cyclic peptides.

22 ization of tandem mass spectra obtained from cyclic peptides.

23 resulting in >=70% conversion to the desired cyclic peptides.

24 erve as macrocyclases in the biosynthesis of cyclic peptides.

25 ses may be ideal catalysts for production of cyclic peptides.

26 A nonphosphorylated cyclic peptide 1 (known as G7-18NATE) inhibits Grb7 via

27 y reported the discovery of a CXCL12-mimetic cyclic peptide (2) as a selective CXCR4 antagonist showi

28 terized nine non-natural triazole-containing cyclic peptides, a further ten molecules are also synthe

29 um levels of TNF-alpha and anticitrullinated cyclic peptide Abs, along with terminal phalanx bone des

30 We have designed a cyclic peptide, Ac-c[CVDINNNC]-NH2, containing the key s

31 ength, and amino acid sequence, the tightest cyclic peptide achieved a Ki value of 2.9 muM against DE

32 esigning cell-permeable, biologically active cyclic peptides against intracellular targets, and the a

33 nucleosides, nucleotides, sulfonamides, and cyclic peptides among other highly polar species.

34 y of different classes of peptide, including cyclic peptides, amyloid peptides and surfactant-like pe

35 kFL, here we report the synthesis of a novel cyclic peptide analogue cyclic WXEAAYQkFL.

36 This program facilitates cyclic peptide analysis, sequencing, and also acts as a

37 act on the product of OLP1, giving rise to a cyclic peptide and concomitant removal of a C-terminal f

38 Optimization of the cyclic peptide and mutagenesis experiments suggest that

39 gate the uncommon fragmentation phenomena of cyclic peptides and aids the characterization of newly d

40 in the inhibitory activity of this class of cyclic peptides and also present a binding model based u

41 eptide macrocyclization toward the design of cyclic peptides and peptidomimetics as calpain inhibitor

42 Cyclic peptides and peptoids were prepared using the thi

43 By screening a focused library of linear and cyclic peptides and performing structure-activity relati

44 o the characterization of structurally novel cyclic peptides, and compares this approach to the recen

45 PNTs have been made from Fmoc dipeptides, cyclic peptides, and lock-washer helical bundles.

46 ),D-Nal(2')(7),Lys(10)]-NH2), a nonselective cyclic peptide antagonist at hMC3R and hMC4R and an agon

47 complex responsible for the synthesis of the cyclic peptide antibiotic Aureobasidin A (AbA) in Aureob

48 are functionalized with polymyxin B (PMB), a cyclic peptide antibiotic with high affinity for LPS.

49 and structural approaches, we show that the cyclic-peptide antibiotic GE23077 (GE) binds directly to

50 ncluding peptide antitumor agents, hormones, cyclic peptide antibiotics, and model proteins.

51 ynthetic reaction, which, for disulfide-rich cyclic peptides, appears to involve asparaginyl endopept

52 (Nod), a group of structurally related small cyclic peptides ( approximately 1000 Da) with more than

53 four contained new structures, including the cyclic peptides arbumycin and arbumelin, the diterpenoid

54 ids and peptide fragments into the homodetic cyclic peptide architecture.

55 Natural and non-natural cyclic peptides are a crucial component in drug discover

56 The resulting cyclic peptides are cell permeable and have improved pro

57 to linear peptides in biological activities, cyclic peptides are considered to have great potential a

58 small set of sequences, the vast majority of cyclic peptides are impermeable to the cell membrane, pr

59 Macrocycles and cyclic peptides are increasingly attractive therapeutic

60 bstrate requirements and demonstrate that KW cyclic peptides are more widespread than anticipated, no

61 Cyclic peptides are promising scaffolds for drug develop

62 Heterocycle-containing cyclic peptides are promising scaffolds for the pharmace

63 Cyclic peptides are reported to have antibacterial, anti

64 Here, we explore cyclic peptides as an alternative class of G4 ligands.

65 es have been developed to routinely identify cyclic peptides as potent, specific inhibitors against p

66 Our findings suggest that the use of cyclic peptides as structural backbones offers a promisi

67 can be applied to synthesize both linear and cyclic peptides, as well as peptides composed of natural

68 locked-open inhibition mechanism placing the cyclic peptide at the bi-domain interface.

69 In this study, we explore the role of the cyclic peptide backbone and cystine ladder in the struct

70 he cyclic cystine ladder motif, comprising a cyclic peptide backbone and three parallel disulfide bon

71 It has been hypothesized that such cyclic peptides balance permeability and solubility usin

72 of an array of conformationally constrained cyclic peptides based on an epitope of the A-B loop with

73 A successful application of a cyclic peptide bearing a thioester handle in native chem

74 mposed of two self-complementary alpha,gamma-cyclic peptides bearing a Zn porphyrin cap that is used

75 nsional crystal structures for 211 bioactive cyclic peptides bound to 65 different proteins.

76 ained from the hierarchical self-assembly of cyclic peptide-bridged amphiphilic diblock copolymers.

77 tandem mass spectrometry data obtained with cyclic peptides but also enables quantitative analysis o

78 portant roles in the passive permeability of cyclic peptides, but other structural features have been

79 lso successfully applied to the formation of cyclic peptides by macrocyclization.

80 Methods: Acid-sensitive cyclic peptide c[E(4)W(5)C] pHLIC was conjugated to bifu

81 These cyclic peptides can be coupled to N-terminal cysteine-co

82 Here we demonstrate that cyclic peptides can be used as ligands to form highly or

83 Compared to small-molecule ligands, cyclic peptides can bind across larger, polar, and water

84 tive targeting of rat PAH lesions by a novel cyclic peptide, CARSKNKDC (CAR).

85 We identified a cyclic peptide, CDAGRKQKC (DAG), that accumulates in the

86 n anti-immunocomplex phage clone bearing the cyclic peptide CFNGKDWLYC.

87 ods; that is, the possibility to explore the cyclic peptide chemotype space not only at the amino aci

88 ogy and that most belong to the macrolide or cyclic peptide class.

89 A bridged cyclic peptide (CN2097), shown by nuclear magnetic reson

90 nities, and determined cryo-EM structures of cyclic peptide complexes.

91 be achieved and/or controlled by varying the cyclic peptide components of similar SWCNT/SCPN hybrids.

92 AP301 [Cyclo(CGQRETPEGAEAKPWYC)], a cyclic peptide comprising the human tumor necrosis facto

93 Cyclotides are a family of plant-derived cyclic peptides comprising six conserved cysteine residu

94 functional theory calculations for studying cyclic peptide conformations in both low-dielectric solv

95 d new mouse MAbs that were able to bind to a cyclic peptide containing E2 residues 412 to 422 (C-epit

96 The synthesis of cyclic peptides containing a thioester handle using a su

97 Here we describe 125 cyclic peptides containing four to thirty-seven amino ac

98 ic method enables the efficient synthesis of cyclic peptides containing gamma-amino acids and is tole

99 Cyclic peptides containing the Arg-Gly-Asp (RGD) sequenc

100 requiring the redesign and synthesis of the cyclic peptide core.

101 d is shown for synthesis of the irreversible cyclic peptide corresponding to the proposed depsipeptid

102 The cyclic peptides could enter cells, inhibit growth and in

103 d upon overexpression of a LEDGF/p75-binding cyclic peptide CP65, originally developed to inhibit the

104 Cyclic peptides (CPs) are a promising class of molecules

105 Caryophyllaceae-type cyclic peptides (CPs) of 5-12 proteinogenic amino acids

106 sterically stable liposomes that contain the cyclic peptides (cRGDyK) with a high affinity to alphavb

107 lical turns, beta-bulges, and alpha-turns in cyclic peptides cross-linked at i, i + 3 and i, i + 4 po

108 d to an antagonist small molecule IT1t and a cyclic peptide CVX15 at 2.5 to 3.2 angstrom resolution.

109 syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide syste

110 CD36 modulators (e.g., 1 and 2) and related cyclic peptides demonstrated that binding affinity corre

111 The reported cyclic peptide demonstrates the utility of our high-thro

112 In this paper, we describe a series of novel cyclic peptides derived from an mRNA display screen whic

113 ssive membrane diffusion in a related set of cyclic peptide diastereomers.

114 ach, with both protein target generation and cyclic peptide discovery performed in vitro, will make o

115 Interestingly, libraries of cyclic peptides displayed a steep drop-off in membrane p

116 Unlike small-molecule drugs, the cyclic peptides do not rely mainly upon hydrophobic and

117 An ideal cyclic peptide drug candidate would be able to recognize

118 e H2a by antibodies or by in silico designed cyclic peptides enables us to reduce luminal monocyte ad

119 ids the characterization of newly discovered cyclic peptides encountered in drug discovery programs.

120 cal structures of emerging TIs suggest these cyclic peptides evolved by internal gene amplification a

121 This cyclic peptide exemplifies potentially a new class of an

122 Pasireotide, a therapeutic cyclic peptide, exhibits poor collision-induced dissocia

123 ive and specific detection of disulfide-rich cyclic peptides extracted from plasma.

124 ve capacity to encode thousands of different cyclic peptides, few of which would display similar ring

125 spectrometry data of the lasso and branched-cyclic peptides for all charge states, including the hig

126 ological interest, e.g. for the synthesis of cyclic peptides for drug design or for protein engineeri

127 ts demonstrate the feasibility of developing cyclic peptides for the inhibition of intracellular prot

128 theta-Defensins are ribosomally synthesized cyclic peptides found in the leukocytes of some primate

129 nnotation program, it was observed that some cyclic peptides fragmented in unexpected ways resulting

130 zation of the peptide chain, cleavage of the cyclic peptide from the resin under mild acidic conditio

131 d in the discovery of a new class of knotted cyclic peptides from the marine sponge Axinella sp.

132 imilar AEP-mediated processing of a class of cyclic peptides from unrelated precursor proteins in phy

133 Short peptides (iRGD is a 9-amino acid cyclic peptide) generally have a plasma half-life measur

134 tus constructed previously, dications of the cyclic peptide Gramicidin S (GS) and the photoactive org

135 zation phenomenon also was observed with the cyclic peptide gramicidin S, indicating the generality o

136 Physisorption of a cyclic peptide, Gramicidin S (GS), was studied for 8 h d

137 However, the cyclic peptide has a unique motional signature in the ap

138 The cyclic peptides have a combination of piperazine or hydr

139 Cyclic peptides have a greater capacity than small-molec

140 Disulfide-rich cyclic peptides have exciting potential as leads or fram

141 Disulfide-rich cyclic peptides have generated great interest in the dev

142 Cyclic peptides have great potential as therapeutic agen

143 Cyclic peptides have long tantalized drug designers with

144 The resulting bioactive cyclic peptides have revealed new insights into structur

145 ed aggregation and fibril reversibility of a cyclic peptide hormone somatostatin (SST)-14 using vario

146 The extent of recombinant AspH-catalyzed cyclic peptide hydroxylation appears to reflect levels o

147 tide thioesters give easy, direct, access to cyclic peptides, illustrated by the synthesis of cyclora

148 Also, the orientation of the cyclic peptide in the antibody-combining site is rotated

149 This suggests that production of cyclic peptides in angiosperms has evolved in parallel u

150 and deselenization to give several different cyclic peptides in good yields.

151 structural modifications that can be made to cyclic peptides in order to achieve such conformational

152 s can illuminate conformational ensembles of cyclic peptides in solution and help identify design opp

153 ylate C-3 of Trp residues in both linear and cyclic peptides in vitro.

154 strated for a range of biologically relevant cyclic peptides, including somatostatin, proteins, and a

155 Cyanobacteria produce a wide variety of cyclic peptides, including the widespread hepatotoxins m

156 In addition, many cyclic peptides incorporate gamma-amino acids and other

157 e show that even a pulse treatment with this cyclic peptide induced parasite death due to proteasome

158 These cell-permeable cyclic peptides inhibit Ras signaling by binding to Ras-

159 e in the apparent affinity for verapamil and cyclic peptide inhibitor QZ59-SSS was observed in deterg

160 and treatment of embryos with stereoisomeric cyclic peptide inhibitors (QZ59 compounds).

161 Two additional P-gp structures with cyclic peptide inhibitors demonstrate distinct drug-bind

162 n and lays the ground for the development of cyclic peptide inhibitors of a vital HIV-1 RNA-protein i

163 Here we report cyclic peptide inhibitors of the KDM4A-C with selectivit

164 We have developed cyclic peptide inhibitors that target UHM domains.

165 In total, 157 syn-BNP cyclic peptides inspired by 96 nonribosomal peptide synt

166 -BNP approach to the design and synthesis of cyclic peptides inspired by nonribosomal peptide synthet

167 In this study, we designed a series of cyclic peptides interacting with both sides of the activ

168 LAG) connected tumor-homing and -penetrating cyclic peptide iRGD to HPMA copolymer.

169 A hexameric oligomer of the cyclic peptide is found in both crystal forms and indica

170 of para-substituted phenylalanine containing cyclic peptides is described.

171 This new family of mostly backbone-cyclic peptides is structurally diverse, but the proteas

172 Two of three cyclic peptides isolated after two rounds of selection c

173 ine arginine (pLR) belongs to a new class of cyclic peptides isolated from frog skin.

174 Cyclotides are bioactive cyclic peptides isolated from plants that are characteri

175 get-binding or pharmacokinetic properties of cyclic peptides, it is frequently necessary to "fine-tun

176 es and filoviruses, and that the PE-specific cyclic peptide lantibiotic agent Duramycin efficiently i

177 at are amenable to the in-cell production of cyclic peptide libraries.

178 acteristic for the creation and screening of cyclic peptide libraries.

179 In this work, a cyclic peptide library was synthesized and screened agai

180 The cyclic peptide ligand was synthesized on a poly(methacry

181 ategy is presented for the identification of cyclic peptide ligands from combinatorial libraries of r

182 All selected cyclic peptide ligands showed 4- to 6-fold stronger affi

183 To identify cyclic-peptide ligands for therapeutic targets, phage-di

184 ch a delivery system based on a 9-amino acid cyclic peptide, LyP-1.

185 This engineered cyclic peptide maintained the overall fold of the natura

186 he results suggest that mRNA display-derived cyclic peptides may be useful in challenging protein cry

187 common structural features that render most cyclic peptides membrane impermeable, as well as the uni

188 have discovered conformationally-constrained cyclic peptide mimetics of Tat that are specific nM inhi

189 However, the new cyclic peptide mimic of Tat represents a new class of li

190 We explored the potential of cyclic peptides mimicking this structure to elicit anti-

191 tural and affinity analyses, we designed two cyclic peptide mimics of the TAR-binding beta2-beta3 loo

192 esent time it is still difficult to annotate cyclic peptides MS/MS spectra.

193 s and resulted in the discovery of three new cyclic peptides, namely microcystin-MhtyR (6), which com

194 n nanotubes (SWCNTs) and the self-assembling cyclic peptide nanotubes (SCPNs).

195 of self-assembled microfibrillar bundles of cyclic peptide nanotubes in water droplets.

196 patial position of microfibrillar bundles of cyclic peptide nanotubes.

197 Total synthesis of the highly functionalized cyclic peptide natural product, ustiloxin D, has been ac

198 Cyclic peptide natural products contain a variety of con

199 Cyclic peptide natural products have evolved to exploit

200 Cyclic peptides obtained via mRNA display bind PHD2 tigh

201 theta-Defensins, the only cyclic peptides of animal origin, have been isolated fro

202 beta-Sheet forming self assembling cyclic peptides offer a versatile scaffold for the const

203 Cyclic peptides offer an attractive solution for present

204 roach makes use of a reactive linker to form cyclic peptides on the phage surface while simultaneousl

205 de (JASP), an actin polymerization-promoting cyclic peptide, or sphingosine-1-phosphate (S1P), a foll

206 e based on a recently described neutralizing cyclic peptide P7 derived from the complementarity-deter

207 e HA stem similar to bnAbs FI6v3 and CR9114, cyclic peptide P7, and small-molecule inhibitor JNJ4796.

208 ibitors I-Pc and Cl-Pc were derived from the cyclic peptide Pc, a mimetic of the C-terminal CK2alpha-

209 ching is an effective, yet untapped, tool in cyclic peptide permeability optimization.

210 te MscL to introduce the cell-impermeable bi-cyclic peptide phalloidin, a specific marker for actin f

211 ion and self-assembly of a new generation of cyclic peptide-polymer conjugates into well-defined phos

212 The thermoresponsive character of the cyclic peptide-polymer conjugates lays the foundation fo

213 By varying the structural parameters of the cyclic peptide-polymer conjugates through the ligation o

214 Small cyclic peptides possess a wide range of biological prope

215 ip (SAR) analysis, we discovered a family of cyclic peptides possessing both Ras-binding and cell-pen

216 pic breast MDA-MB-231 tumors showed that the cyclic peptide preferentially accumulates in tumor (2 h

217 -mining, we discovered that anabaenopeptins, cyclic peptides produced by cyanobacteria, were potent i

218 s are a rapidly growing family of linear and cyclic peptides produced by cyanobacteria.

219 g from 35 to 70 amino acids, are the largest cyclic peptides produced by lactic acid bacteria to supp

220 lase 1, we identified AEPs and PALs from the cyclic peptide-producing plants Viola yedoensis (Vy) and

221 icity requirements at the excision sites for cyclic peptide production.

222 These cyclic peptides protected K48-linked Ub chains from deub

223 The cyclic peptides reported here as DENV protease inhibitor

224 rationale for functional nanotubes based on cyclic peptide ring size and chemical functionality is d

225 eplacing the noncritical residues within the cyclic peptide ring with arginine residues and shown to

226 gens, Tn and STn, were assembled on a single cyclic peptide scaffold in a highly convergent manner.

227 hese peptides by grafting them into a stable cyclic peptide scaffold may enhance their therapeutic po

228 of geometrically diverse, membrane permeable cyclic peptide scaffolds based on the synthesis and perm

229 one diversity and improve ADME properties in cyclic peptide scaffolds.

230 en and CB[8] (MVCB[8]) within a vast pool of cyclic peptide sequences.

231 y asparaginyl endopeptidases (AEPs) into the cyclic peptide SFTI-1 (sunflower trypsin inhibitor-1) an

232 Many protein-bound cyclic peptides show backbone structures like those (str

233 Correlation analysis of the reduced cyclic peptide shows that two of the three disulfide dis

234 ptide backbones and side chains to fine-tune cyclic peptide structure.

235 the fragment are fused into a macrocycle (= cyclic peptide) structure, thus "losing" the memory of t

236 ouple to conductivity detection) analysis of cyclic peptides subjected to the SFC conditions, indicat

237 ich is supported by studies involving stable cyclic peptide substrate analogues and by effects of Ca(

238 hyl-lysine or methylated arginine results in cyclic peptide substrates, indicating that KDM4s may act

239 uct in the biosynthesis of several bioactive cyclic peptides such as lantibiotics, thiopeptides, and

240 lly annotated the sequence of representative cyclic peptides, such as seglitide, tyrothricin, desmeth

241 ores functionalized by the side chain of the cyclic peptide, suggesting a general method to form func

242 Here, we used the nature-derived cyclic peptide sunflower trypsin inhibitor-1 (SFTI-1) as

243 The plant-derived cyclic peptide, sunflower trypsin inhibitor-1 (SFTI-1),

244 atile intermediates for peptide ligation and cyclic peptide synthesis.

245 roves both the convergence and divergence of cyclic peptide synthesis.

246 -soluble probe consisting of a 26-amino acid cyclic peptide that binds the human tyrosine kinase c-Me

247 Here, we present the discovery of a 16-mer cyclic peptide that binds to Cdc42 with nanomolar affini

248 A NIR fluorochrome was conjugated to a cyclic peptide that binds to integrin alpha5beta1, a fac

249 discovery of a novel proteolytically stable cyclic peptide that can be used for targeted drug delive

250 sing this approach, we have designed a novel cyclic peptide that comprises a small bioactive peptide

251 peptide mimic of the Tat basic domain and a cyclic peptide that potently inhibits Tat-dependent acti

252 psin inhibitor-1 (SFTI-1) is a 14-amino acid cyclic peptide that shares an inhibitory loop with a seq

253 Orbitides are a class of cyclic peptides that are small, head-to-tail cyclized, c

254 Meditopes are cyclic peptides that bind in a specific pocket in the an

255 n and characterization of two such unnatural cyclic peptides that bind the protease thrombin with low

256 Using this approach, we identified cyclic peptides that irreversibly inhibited a cysteine p

257 port a bacterial system for the evolution of cyclic peptides that makes use of an expanded set of ami

258 to explore if PET imaging using hydrophobic cyclic peptides that partition into the cellular membran

259 The goal was to develop smaller partially cyclic peptides that retain the antiviral activity of re

260 We here report d/l-alternating cyclic peptides that undergo one-dimensional self-assemb

261 atalytic site of PPM1D and inhibition by the cyclic peptides that will be useful both for the subsequ

262 ables the emergence of extensively different cyclic peptides through short mutational paths based on

263 eported methods for producing disulfide-rich cyclic peptides, thus offering great potential to facili

264 synthesized by conjugation of a known short cyclic peptide to a cross-bridged chelator (CB-TE2A), fo

265 peptide topologies, indicating the branched-cyclic peptide to be folded in the gas phase into a conf

266 lum and reveal the first functional Agr-type cyclic peptide to be produced by a thermophilic member o

267 tion at D-Lys(2)-Xxx(3) is crucial for these cyclic peptides to maintain high affinity, selectivity,

268 d MOR agonist/DOR antagonist behavior in the cyclic peptides to the tetrahydroquinoline scaffold and

269 Furthermore, a self-sorting of the cyclic peptides toward semiconducting rather than metall

270 Cyclic peptide triazoles (cPTs) retained the gp120 inhib

271 ur results demonstrate that selection of (bi)cyclic peptides unlocks a valuable chemical space for ta

272 A novel approach to synthesize cyclic peptides via A(3)-macrocyclization has been used

273 In the case of longer, linear or cyclic peptides, vice versa results are obtained.

274 The cyclic peptides violated to different degrees all of the

275 bilized on gold microcantilever surface, the cyclic peptide was able to capture breast cancer cells s

276 To address this gap, a genetically encoded cyclic peptide was designed based on the sonic hedgehog

277 s outside the FXIIa active site, a synthetic cyclic peptide was tested.

278 e family in which evolidine, the first plant cyclic peptide, was discovered.

279 the overall fold of the naturally occurring cyclic peptide, was more effective at reducing inflammat

280 the discovery of cyclotides and related non-cyclic peptides we called "acyclotides" from petunia of

281 The protein-bound cyclic peptides were examined for similarities and diffe

282 De novo cyclic peptides were found that can bind tightly and spe

283 d its carbamate-protected form in linear and cyclic peptides were investigated using NMR and alpha-ch

284 terials formulated as sterically constrained cyclic peptides which flow freely for low resistance inj

285 lationships have been extensively studied in cyclic peptides whose backbones are cyclized from head t

286 listatins is one of the families of Pro-rich cyclic peptides whose synthetic counterparts have reveal

287 In a control experiment, a protonated cyclic peptide with 6 amino acid residues, cyclo(Gln-Trp

288 s matured into SFTI-1, a protease-inhibiting cyclic peptide with a motif homologous to unrelated inhi

289 ormation of a stable 4-imidazolidinone-fused cyclic peptide with high diastereoselectivity (>99 %).

290 MCoTI-II is a head-to-tail cyclic peptide with potent trypsin inhibitory activity a

291 apsule based on a beta-sheet self-assembling cyclic peptide with the ability to recognize and release

292 timization from library screening produced a cyclic peptide with ~100-fold improved activity over the

293 -activity relationship analysis, we designed cyclic peptides with 4-fold improved binding affinity fo

294 Fusion of cyclic peptides with a cyclic cell-penetrating peptide p

295 of membrane-permeable scaffolds to identify cyclic peptides with good to excellent passive cell perm

296 Inspired by a series of cyclic peptides with partially elucidated structures, we

297 peptide cyclo(d-Ala-Ala5 ); 2) selection of cyclic peptides with the highest intestinal permeability

298 tly increased the inhibitory activity of the cyclic peptide, with the optimized molecule having a K(i

299 d trans isomers were obtained for all of the cyclic peptides, with the ratio of cis to trans isomers

300 tegy for engineering conformationally rigid, cyclic peptides without the need for disulfide-bond rein