ライフサイエンスコーパス: cyclin-dependent kinase 5

1 ptor, Neuropilin 1 (NRP1), and activation of cyclin dependent kinase 5.

2 ndent on prior phosphorylation of Ser-778 by cyclin-dependent kinase 5.

3 nerated CAD cells results from activation of cyclin-dependent kinase 5.

4 EB enhanced the overactivation of cyclin-dependent kinase 5.

5 ing with the phosphatase PP2A and the kinase cyclin-dependent kinase 5.

6 tor erythroid 2-related factor 2, notch, and cyclin-dependent kinase 5.

7 lcineurin, and was opposed by the actions of cyclin-dependent kinase 5.

8 , leads to tau phosphorylation by activating cyclin-dependent kinase 5.

9 The activity of cyclin-dependent kinase 5, a major kinase involved in bo

10 GRASP65, which is induced by Abeta-triggered cyclin-dependent kinase-5 activation.

11 a novel interaction between muskelin and the cyclin-dependent kinase 5 activator p39 and suggest that

12 ss is accompanied by generation of the Cdk5 (cyclin-dependent kinase 5)-activator p25, up-regulation

13 (n=12-14; P<0.05), and significantly higher cyclin-dependent kinase 5 activity (n=4; P<0.001).

14 r ratios of p25/p35, indicative of increased cyclin-dependent kinase 5 activity as compared with wild

15 using roscovitine and siRNA directed towards cyclin-dependent kinase 5) ameliorated the cilia phenoty

16 tion is enhanced by prior phosphorylation by cyclin-dependent kinase 5 and antagonized by Fyn phospho

17 ncreased phosphorylation of ezrin at T235 by cyclin-dependent kinase 5 and consequent dissociation of

18 mutations abolished Thr21 phosphorylation by cyclin-dependent kinase 5 and external signal regulated

19 lens library for proteins that interact with cyclin-dependent kinase 5 and its regulators, p35 and p3

20 Pharmacological inhibitors of cyclin-dependent kinase 5 and p38 mitogen-activated prot

21 AD, glycogen synthase kinase-3 beta (GSK3B), cyclin-dependent kinase-5 and dual specificity tyrosine-

22 Significantly, both inhibition of cyclin-dependent kinase-5 and expression of nonphosphory

23 including glycogen synthase kinase 3beta and cyclin-dependent kinase-5 and its activators p25 and p35

24 lycogen synthase kinase-3 beta (GSK-3 beta), cyclin-dependent kinase 5, and c-Jun NH(2)-terminal kina

25 ion of DeltaFosB, prodynorphin, dynorphin A, cyclin-dependent kinase 5, and increased phosphorylation

26 robust up-regulation of striatal DeltaFosB, cyclin-dependent kinase 5, and p35.

27 e homolog-1, glycogen synthase kinase 3beta, cyclin-dependent kinase 5, and tau protein phosphatase 2

28 he cytoplasmic serine/threonine kinase Cdk5 (cyclin-dependent kinase 5) are both required for normal

29 ave now identified the neuronal kinase Cdk5 (cyclin-dependent kinase 5) as an important regulator of

30 kinase, CaM kinase II, casein kinase II, or cyclin-dependent kinase 5, at concentrations 50 or more

31 s associated with a significant elevation in cyclin dependent kinase-5 but not other kinases that hav

32 ntrast, inhibiting protein tyrosine kinases, cyclin-dependent kinase 5, Ca(2+)/calmodulin-dependent k

33 The cyclin-dependent kinase 5 (CDK-5) activating protein, p3

34 Cyclin-dependent kinase 5 (CDK-5) and its activator CDKA

35 carboxy-terminal tail portion by the enzyme cyclin-dependent kinase 5 (CDK-5).

36 In addition, cyclin-dependent kinase-5 (CDK-5) facilitates new synaps

37 We previously showed that cyclin-dependent kinase-5 (CDK-5) positively regulates t

38 Cyclin dependent kinase 5 (Cdk5) contributes to neuronal

39 Here, we demonstrate that cyclin dependent kinase 5 (Cdk5), a protein known to fun

40 Here, we demonstrate that cyclin dependent kinase-5 (Cdk5) associates with and pho

41 We identify aberrant Cyclin-dependent kinase 5 (Cdk5) activity as a principal

42 Our study in mice demonstrates that cyclin-dependent kinase 5 (Cdk5) activity is modulated b

43 Cyclin-dependent kinase 5 (Cdk5) activity is significant

44 ent studies suggest that deregulation of p25/Cyclin-dependent kinase 5 (Cdk5) activity leads to the h

45 We have previously reported that cyclin-dependent kinase 5 (Cdk5) activity regulates noci

46 rn up-regulated p35 expression and increased cyclin-dependent kinase 5 (Cdk5) activity.

47 th a significant increase in activity of the cyclin-dependent kinase 5 (cdk5) and accumulation of its

48 ent time- and dose-dependent stimulations of cyclin-dependent kinase 5 (cdk5) and calcium/calmodulin-

49 g pharmacologic inhibitors of PI3K, Akt, and cyclin-dependent kinase 5 (cdk5) and constitutively acti

50 action content decreases after inhibition of cyclin-dependent kinase 5 (Cdk5) and ERK1/2.

51 by sequential phosphorylation by the kinases cyclin-dependent kinase 5 (Cdk5) and glycogen synthase k

52 Cyclin-dependent kinase 5 (cdk5) and glycogen synthase k

53 ivation of proline-directed kinases, such as cyclin-dependent kinase 5 (Cdk5) and glycogen synthase k

54 es responsible for these phosphorylations as cyclin-dependent kinase 5 (CDK5) and glycogen synthase k

55 ed amyloid beta (Abeta)-induced decreases in cyclin-dependent kinase 5 (Cdk5) and increases in CXCL1

56 Neuronal migration is also regulated by cyclin-dependent kinase 5 (Cdk5) and its activating subu

57 In the CNS, cyclin-dependent kinase 5 (Cdk5) and its activator p35 a

58 Cyclin-dependent kinase 5 (Cdk5) and its activator p35 h

59 Cyclin-dependent kinase 5 (Cdk5) and its activator p35,

60 ients has been linked to overactivity of the cyclin-dependent kinase 5 (CDK5) and its activator p35.

61 Phosphorylated tau as well as cyclin-dependent kinase 5 (cdk5) and its coactivator, p2

62 Cyclin-dependent kinase 5 (cdk5) and its neuron-specific

63 Cyclin-dependent kinase 5 (Cdk5) and its neuron-specific

64 Cyclin-dependent kinase 5 (Cdk5) and its regulatory subu

65 Furthermore, Cadm4, cyclin-dependent kinase 5 (Cdk5) and p39 mRNAs were sign

66 Here, we report that the activity of cyclin-dependent kinase 5 (Cdk5) and the conversion of i

67 reover, A-705253 decreased the activation of cyclin-dependent kinase 5 (CDK5) and thereby diminished

68 Here we identify cyclin-dependent kinase 5 (Cdk5) as a downstream target

69 Here we investigate the inhibition of cyclin-dependent kinase 5 (Cdk5) as a promising combinat

70 ied in soluble form and is phosphorylated by cyclin-dependent kinase 5 (CDK5) as well as by CaMKII.

71 EPRS is dually phosphorylated by cyclin-dependent kinase 5 (Cdk5) at Ser(886) and then by

72 as previously reported to be a substrate for cyclin-dependent kinase 5 (Cdk5) at Ser67.

73 unction is inhibited upon phosphorylation by cyclin-dependent kinase 5 (Cdk5) at Thr345.

74 WAVE1 is phosphorylated at multiple sites by cyclin-dependent kinase 5 (Cdk5) both in vitro and in in

75 -type controls, resulting from activation of cyclin-dependent kinase 5 (CDK5) but not glycogen syntha

76 se in cyclin D1 attenuates the activation of cyclin-dependent kinase 5 (cdk5) by its neuronal activat

77 The deregulation of cyclin-dependent kinase 5 (Cdk5) by p25 has been shown t

78 ent requires tightly regulated activation of Cyclin-dependent kinase 5 (Cdk5) by two distinct cofacto

79 Furthermore, stabilization of HIF1alpha by cyclin-dependent kinase 5 (CDK5) enabled it to promote t

80 discovered that phosphorylation of Dixdc1 by cyclin-dependent kinase 5 (Cdk5) facilitates its interac

81 hatase calcineurin (CNAalpha) and the kinase cyclin-dependent kinase 5 (CDK5) has a dramatic influenc

82 Cyclin-dependent kinase 5 (cdk5) has been implicated in

83 Although the neuronal protein kinase cyclin-dependent kinase 5 (Cdk5) has been implicated in

84 While deregulation of cyclin-dependent kinase 5 (Cdk5) has been implicated in

85 Cyclin-dependent kinase 5 (Cdk5) has been involved in pr

86 Recently, cyclin-dependent kinase 5 (Cdk5) has been shown to funct

87 Cyclin-dependent kinase 5 (CDK5) has been shown to influ

88 ated receptor gamma (PPARgamma) at Ser273 by cyclin-dependent kinase 5 (CDK5) in adipose tissue stimu

89 An essential role of cyclin-dependent kinase 5 (Cdk5) in brain development ha

90 duce the overexpression of neuronal-specific cyclin-dependent kinase 5 (Cdk5) in breast cancer-derive

91 t of MAPKs and proline-directed kinases like cyclin-dependent kinase 5 (Cdk5) in cell-based as well a

92 odynia and upregulates Ca(V)3.2 channels and cyclin-dependent kinase 5 (Cdk5) in dorsal root ganglia

93 Here, we demonstrate a novel role for p25/cyclin-dependent kinase 5 (Cdk5) in regulating APP proce

94 Recent studies implicate the cyclin-dependent kinase 5 (Cdk5) in regulating oligodend

95 We recently identified an essential role for cyclin-dependent kinase 5 (Cdk5) in T-cell activation an

96 Although tau is phosphorylated by cyclin-dependent kinase 5 (Cdk5) in vitro, its in vivo r

97 Cyclin-dependent kinase 5 (Cdk5) is a brain-specific mem

98 Cyclin-dependent kinase 5 (Cdk5) is a critical regulator

99 Cyclin-dependent kinase 5 (Cdk5) is a member of the fami

100 Cyclin-dependent kinase 5 (Cdk5) is a multi-faced kinase

101 Cyclin-dependent kinase 5 (Cdk5) is a multifunctional ne

102 Cyclin-dependent kinase 5 (Cdk5) is a nontraditional Cdk

103 Our laboratory has shown that cyclin-dependent kinase 5 (Cdk5) is a potent cell cycle

104 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed k

105 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed s

106 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed s

107 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed s

108 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed s

109 Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine k

110 Cyclin-dependent kinase 5 (cdk5) is a serine/threonine k

111 Cyclin-dependent kinase 5 (Cdk5) is a small serine/threo

112 Cyclin-dependent kinase 5 (Cdk5) is a ubiquitously expre

113 e with a targeted disruption in the gene for cyclin-dependent kinase 5 (cdk5) is abnormal in its stru

114 Here, we show that cyclin-dependent kinase 5 (Cdk5) is activated by ACh ago

115 Cyclin-dependent kinase 5 (Cdk5) is activated by the neu

116 Cyclin-dependent kinase 5 (Cdk5) is activated on binding

117 Cyclin-dependent kinase 5 (Cdk5) is an atypical but esse

118 Here, we report for the first time that cyclin-dependent kinase 5 (Cdk5) is an essential regulat

119 Here, we show that cyclin-dependent kinase 5 (Cdk5) is an essential regulat

120 Although cyclin-dependent kinase 5 (Cdk5) is closely related to o

121 It has been shown that cyclin-dependent kinase 5 (Cdk5) is crucial for neuronal

122 Cyclin-dependent kinase 5 (Cdk5) is essential for the pr

123 Cyclin-dependent kinase 5 (CDK5) is expressed at high le

124 Cyclin-dependent kinase 5 (cdk5) is found in an active f

125 Recent evidence indicates that cyclin-dependent kinase 5 (Cdk5) is inappropriately acti

126 pha(1)beta(1) integrin-induced activation of cyclin-dependent kinase 5 (cdk5) is involved in neurite

127 Cyclin-dependent kinase 5 (CDK5) is known to underlie bo

128 Cyclin-dependent kinase 5 (Cdk5) is much more than its n

129 Cyclin-dependent kinase 5 (Cdk5) is one of a subfamily o

130 Cyclin-dependent kinase 5 (Cdk5) is predominantly expres

131 Here we show that cyclin-dependent kinase 5 (Cdk5) is required for dbcAMP

132 Cyclin-dependent kinase 5 (Cdk5) is required for proper

133 Although cyclin-dependent kinase 5 (Cdk5) is widely expressed in

134 the algorithm, we showed that inhibition of Cyclin-dependent kinase 5 (Cdk5) led to reduced branchin

135 Cyclin-dependent kinase 5 (Cdk5) mediates neurotoxic eff

136 Cyclin-dependent kinase 5 (CDK5) negatively regulates po

137 Cyclin-dependent kinase 5 (Cdk5) null mice exhibit a uni

138 Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrat

139 Cyclin-dependent kinase 5 (CDK5) phosphorylated DRP1 to

140 ulatory cell signals for CAP1, we found that cyclin-dependent kinase 5 (CDK5) phosphorylates both Ser

141 Here, we show that cyclin-dependent kinase 5 (Cdk5) phosphorylates synaptoj

142 Cyclin-dependent kinase 5 (Cdk5) phosphorylation of wild

143 Although cyclin-dependent kinase 5 (Cdk5) plays a critical role i

144 Cyclin-dependent kinase 5 (Cdk5) plays a key role in the

145 Cyclin-dependent kinase 5 (Cdk5) plays a pivotal role in

146 Growing evidence suggests that cyclin-dependent kinase 5 (cdk5) plays a role in tau pho

147 The proline-directed serine/threonine kinase cyclin-dependent kinase 5 (cdk5) plays an important role

148 Cyclin-dependent kinase 5 (Cdk5) plays key roles in norm

149 Cyclin-dependent kinase 5 (Cdk5) regulates dopamine neur

150 Cyclin-dependent kinase 5 (Cdk5) regulates striatal dopa

151 Cyclin-dependent kinase 5 (Cdk5) regulates striatal dopa

152 Here, we show that the cyclin-dependent kinase 5 (CDK5) regulates the mammalian

153 Cyclin-dependent kinase 5 (CDK5) regulatory subunit-asso

154 ant brain tumors where type-II inhibition of cyclin-dependent kinase 5 (CDK5) stabilizing the DFG-out

155 r-activated receptor gamma) at serine 273 by cyclin-dependent kinase 5 (Cdk5) stimulates diabetogenic

156 ites that were mediated by the activation of cyclin-dependent kinase 5 (cdk5) through increased forma

157 mechanism by which phosphorylation of GIV by cyclin-dependent kinase 5 (CDK5) triggers GIV's ability

158 Cyclin-dependent kinase 5 (CDK5) was identified as an SI

159 Cyclin-dependent kinase 5 (Cdk5) was originally isolated

160 neural-specific activating subunit, p35, of cyclin-dependent kinase 5 (Cdk5) was recently reported t

161 In our previous study, cyclin-dependent kinase 5 (cdk5) was shown to phosphoryl

162 Recently, cyclin-dependent kinase 5 (Cdk5) was shown to phosphoryl

163 CNS myelination, including the noncanonical cyclin-dependent kinase 5 (Cdk5) whose functions are reg

164 Cyclin-dependent kinase 5 (Cdk5), a complex of Cdk5 and

165 ry tangles (NFTs), it has been reported that cyclin-dependent kinase 5 (Cdk5), a critical neuronal ki

166 We show here that cyclin-dependent kinase 5 (CDK5), a known regulator of m

167 Cyclin-dependent kinase 5 (Cdk5), a member of the Cdc2 f

168 One candidate for such regulation is cyclin-dependent kinase 5 (Cdk5), a member of the Cdc2 f

169 Cyclin-dependent kinase 5 (CDK5), a neuronal kinase that

170 Here, we show that cyclin-dependent kinase 5 (CDK5), a Pro-directed Ser/Thr

171 ns three consensus phosphorylation sites for cyclin-dependent kinase 5 (cdk5), a proline-directed ser

172 Here, we show that cyclin-dependent kinase 5 (Cdk5), a protein kinase that

173 Here, we show that cyclin-dependent kinase 5 (Cdk5), a serine-threonine kin

174 Cyclin-dependent kinase 5 (CDK5), aberrantly active in c

175 Cyclin-dependent kinase 5 (CDK5), an atypical member of

176 inction requires downregulation of Rac-1 and cyclin-dependent kinase 5 (Cdk5), and upregulation of p2

177 ycogen synthase kinase-3beta (GSK-3beta) and cyclin-dependent kinase 5 (Cdk5), as well as nonproline-

178 The aberrant hyperactivation of Cyclin-dependent kinase 5 (Cdk5), by the production of i

179 glycogen synthase kinase-3beta (GSK-3beta), cyclin-dependent kinase 5 (Cdk5), cAMP-dependent protein

180 In this study, an identified cyclin-dependent kinase 5 (cdk5), isolated from nervous

181 ngly sensitised to PARP inhibitor, including cyclin-dependent kinase 5 (CDK5), MAPK12, PLK3, PNKP, ST

182 The cyclin-dependent kinase 5 (CDK5), originally described a

183 his pathway involves enzymatic activities of cyclin-dependent kinase 5 (CDK5), protein phosphatase 1

184 Hyperactivation of the cyclin-dependent kinase 5 (cdk5), triggered by proteolyt

185 Cyclin-dependent kinase 5 (CDK5), unlike other CDKs, is

186 Cyclin-dependent kinase 5 (Cdk5), which binds to and is

187 In HEK293 cells, high NaCl activates cyclin-dependent kinase 5 (CDK5), which directly phospho

188 p35, is known to induce aberrant activity of cyclin-dependent kinase 5 (Cdk5), which is associated wi

189 factors, p35 and p39, independently activate Cyclin-dependent kinase 5 (Cdk5), which plays diverse ro

190 degradation of the p35 regulatory subunit of cyclin-dependent kinase 5 (Cdk5), with the resultant dec

191 Mice deficient in p35--an activator of cyclin-dependent kinase 5 (Cdk5)--are characterized by a

192 e find that glutamate-dependent reduction in cyclin-dependent kinase 5 (Cdk5)-dependent RIIbeta phosp

193 sters that are not stabilized by agrin via a cyclin-dependent kinase 5 (Cdk5)-mediated mechanism, but

194 tubule affinity regulating kinase)/PAR1, and cyclin-dependent kinase 5 (CDK5).

195 One of the upregulated genes is cyclin-dependent kinase 5 (cdk5).

196 f PKA when phosphorylated at threonine 75 by cyclin-dependent kinase 5 (Cdk5).

197 lation of acetyl-CoA synthetase 2 (ACSS2) by cyclin-dependent kinase 5 (CDK5).

198 otes dedifferentiation through activation of cyclin-dependent kinase 5 (CDK5).

199 ed via activity-dependent phosphorylation by cyclin-dependent kinase 5 (Cdk5).

200 ated by RG108-estrogen receptor 1 (ESR1) and cyclin-dependent kinase 5 (CDK5).

201 hat serine 1116 of NR2B is phosphorylated by cyclin-dependent kinase 5 (Cdk5).

202 he N-type calcium channel is a substrate for cyclin-dependent kinase 5 (Cdk5).

203 t Ser(424) and Ser(429) in the C terminus by cyclin-dependent kinase 5 (Cdk5).

204 Cyclin-dependent kinase 5 (cdk5)/p35 kinase activity is

205 highly conserved phosphorylation site and by cyclin-dependent kinase-5 (Cdk5) at a newly described si

206 Cyclin-dependent kinase-5 (Cdk5) is a serine/threonine k

207 The activity of cyclin-dependent kinase-5 (Cdk5) is tightly regulated by

208 In this study, we reported that cyclin-dependent kinase-5 (Cdk5) regulates Akt activity

209 Cyclin-dependent kinase-5 (Cdk5) was reported to downsca

210 lycogen synthase kinase-3beta (GSK3beta) and cyclin-dependent kinase-5 (CDK5), are involved in the ne

211 uding glycogen synthase kinase 3 (GSK-3) and cyclin-dependent kinase-5 (Cdk5), to phosphorylate sever

212 Cyclin-dependent kinase 5(CDK5) in complex with its acti

213 Cyclin-dependent kinase 5(cdk5) is highly homologous to

214 Cyclin-dependent kinase 5, coupled with its activator p3

215 as phosphorylation sinks where they mitigate cyclin-dependent kinase 5 dysregulation induced by mutan

216 We also found that cyclin-dependent kinase-5 expression is upregulated duri

217 These include the modelling of Cdk5 (cyclin-dependent kinase 5) from Cdk2, thymidine phosphor

218 Previous studies implicate cyclin-dependent kinase 5 in cell adhesion and migration

219 purmorphamine treatment was shown to reduce cyclin-dependent kinase 5 in patient cells, suggesting a

220 phenomenon associated with the activation of cyclin-dependent kinase 5 in several neurodegenerative d

221 67) of inhibitor-1 serves as a substrate for cyclin-dependent kinase 5 in the brain.

222 t feeding activates the protein kinase Cdk5 (cyclin-dependent kinase 5) in adipose tissues.

223 Cyclin-dependent kinase 5 is activated by small subunits

224 de of both glycogen synthetase kinase 3B and cyclin-dependent kinase 5 is required to prevent P301L-i

225 of both glycogen synthetase kinase 3beta and cyclin-dependent kinase 5 is required to prevent P301L-i

226 nd that c-Jun NH2-terminal kinase (JNK), not cyclin-dependent kinase 5, is required for APP phosphory

227 of histone modifications at the murine Cdk5 (cyclin-dependent kinase 5) locus, given growing evidence

228 ermore, 7j is highly effective in preventing cyclin-dependent kinase 5-mediated phosphorylation of PP

229 trations in which olomoucine is specific for cyclin-dependent kinases (5 microM), it reduced only ant

230 ddition, levels of the activation subunit of cyclin-dependent kinase 5, p25, are elevated significant

231 The neuronal-specific activator of cyclin-dependent kinase 5, p35, has been recognized as a

232 , extracellular signal-regulated kinase, and cyclin-dependent kinase-5 pathways.

233 inase C phosphorylation site, and Thr-574, a cyclin-dependent kinase 5 phosphorylation site, regulate

234 We show here that CDK5 (cyclin-dependent kinase 5) plays a role.

235 that p35, the neuronal-specific activator of cyclin-dependent kinase 5, plays a key role in proper ne

236 of both glycogen synthetase kinase 3beta and cyclin-dependent kinase 5 prevents tau mislocalization t

237 de of both glycogen synthetase kinase 3B and cyclin-dependent kinase 5 prevents tau mislocalization t

238 Cyclin-dependent kinase 5 regulates numerous neuronal fu

239 Previously identified risk variants in cyclin-dependent kinase 5 regulatory subunit associated

240 PP1), and phosphorylation at Thr-75 by Cdk5 (cyclin-dependent kinase 5) results in inhibition of prot

241 The functions of cyclin-dependent kinase 5 signalling in cognition and co

242 er-137, and decreases phosphorylation at the cyclin-dependent kinase 5 site, Thr-75.

243 r34 (protein kinase A site, Thr34A), Thr75, (cyclin-dependent kinase 5 site, Thr75A), Ser97 (kinase C

244 phosphorylation state at Thr75-DARPP-32, the cyclin-dependent kinase 5 site.

245 f Drp1 (dynamin-related protein 1) and Cdk5 (cyclin-dependent kinase 5), targets known to contribute

246 In contrast, Ser(67) phosphorylation by cyclin-dependent kinase 5 was unaffected by phospho-Ser(