ライフサイエンスコーパス: cyclization

1 eterochiral molecules (one of them involving cyclization).

2 a highly diastereoselective Pictet-Spengler cyclization.

3 nd its subsequent intramolecular aza-Michael cyclization.

4 ituted trienes that are resistant to thermal cyclization.

5 s well as increased control over the rate of cyclization.

6 ive C(7)-H functionalization and concomitant cyclization.

7 mines and their subsequent fragmentation and cyclization.

8 ole as the nucleophilic partner in the first cyclization.

9 cluding polysubstituted olefin formation and cyclization.

10 itions, specifically the degree of core GDGT cyclization.

11 e formation of a 1,4-diradical by an initial cyclization.

12 noline-, and quinoline ynones, via 5-exo-dig cyclization.

13 talytic cycle via intramolecular dehydration/cyclization.

14 ectrocyclic mechanism analogous to a Nazarov cyclization.

15 enantioselective Morita-Baylis-Hillman (MBH) cyclization.

16 ic attack by pyridyl nitrogen results in its cyclization.

17 lable and could also be applied to a cascade cyclization.

18 h undergoes spontaneous transannular Mannich cyclization.

19 enamine intermediate followed by 1,5-exo-dig cyclization.

20 stereoselectivity resulting from the radical cyclization.

21 th boronic acids, followed by intramolecular cyclization.

22 droxyaspartic acid ligation-mediated peptide cyclization.

23 ilability, in influencing the degree of GDGT cyclization.

24 vinylogous alpha-amido radical formed after cyclization.

25 thoxyaryl)propiolates for thiocyanative ipso-cyclization.

26 intermediates that readily engage in Nazarov cyclizations.

27 re development of asymmetric 2-imino-Nazarov cyclizations.

28 inium ions that undergo Pictet-Spengler-type cyclizations.

29 ase-mediated Michael addition/intramolecular cyclization/[1,5]-H shift/cleavage of CS(2)/aromatizatio

30 yzed propargyl Claisen rearrangement/Nazarov cyclization, a [4+2] cycloaddition of the formed six- or

31 Via an intramolecular Friedel-Crafts cyclization, a dihydrobenzofuranone was obtained.

32 y peptides that could benefit from bioactive cyclization, a strategy that is amenable to broad applic

33 tive sites in the C and T domains diminished cyclization activity of GliP in vitro and abolished glio

34 The N-cyclization-alkylation cascade introduces a novel retros

35 The cyclization also proceeds with tosylamides forming C-N b

36 However, the extent of this cyclization also varies with growth phase and electron a

37 e reaction undergoes feasible steps that are cyclization and 1,2-H shift before elimination to persis

38 se events, which included a unique Conia-ene cyclization and a challenging Pauson-Khand reaction, aff

39 reaction appears to proceed via a Dieckmann cyclization and a retro-aldol elimination, releasing amm

40 )/CeO(2) greatly enhances the selectivity of cyclization and aromatization in the n-hexane reforming

41 vity of single-site Pt(1)/CeO(2) toward both cyclization and aromatization is above 86% at 350 degree

42 nism underpinning the complex process of GPA cyclization and furthermore show the utility of the tech

43 We also showed that the cyclization and ligation of peptides and proteins with v

44 molecules that are capable of both efficient cyclization and of pre-organizing another precursor to e

45 by an intramolecular 1,6-conjugate addition/cyclization and oxidation sequence.

46 The role of NHC in the intramolecular cyclization and preliminary mechanistic experiments are

47 st control through stereoselective oxidative cyclization and subsequent, stereospecific allyl-isomeri

48 from a nonaromatic enediyne core via Bergman cyclization and Suzuki-Miyaura coupling of the resulting

49 roso-intermediate are proposed for oxidative cyclization and the unexpected intermolecular displaceme

50 P is discussed, including their formation by cyclizations and oligomerizations of aldehydes and creat

51 ade involving Cope rearrangement, 6-exo-trig cyclization, and a final electrophilic aromatic substitu

52 This approach allowed one-pot deprotection, cyclization, and deselenization to give several differen

53 formation, Michael addition, intramolecular cyclization, and intramolecular iminium ion cyclization

54 -hydrogen atom translocation, intramolecular cyclization, and rearomatization steps lead to valuable

55 yzed sequences involving oxidative addition, cyclization, and termination through intermolecular nucl

56 plexity-building Mannich reaction, efficient cyclizations, and a highly diastereoselective hydrogenat

57 and stereoselective intramolecular oxidative cyclization; and (c) a complexity-generating aza-Cope/Ma

58 ole and (ii) a three-step cross-coupling and cyclization approach starting from the zincated 4,6-dich

59 embered enediynes' reactivity in the Bergman cyclization are also reported.

60 atalyst-controlled intra- and intermolecular cyclizations are mainly described to give five- and six-

61 rted solid-state topochemical polymerization/cyclization-aromatization strategy to convert the simple

62 n of these N-oxides enabled a formal Cadogan cyclization at room temperature for 2 H-indazole synthes

63 ransformation involving two independent peri-cyclizations at the central core.

64 A mechanism is proposed for this cyclization based on DFT calculations.

65 We also reveal the mechanism of the cyclization based on DFT modeling and obtain a clear cor

66 enyl)isoquinoline-2-oxides via electrophilic cyclization between alkynylbenzaldoximes and diorganyl d

67 esults support the hypothesis that oxidative cyclization between amino acid nitrogen and the prenyl c

68 ns, this observation suggested that the 3',8-cyclization by MoaA is accelerated by 6-9 orders of magn

69 synthetic strategies including head-to-tail cyclization (C1), side-chain-to-tail cyclization (C2), a

70 to-tail cyclization (C1), side-chain-to-tail cyclization (C2), and a disulfide bond cross-linkage (C3

71 The cyclization can also be extended to the formation of six

72 An efficient two-component copper-catalyzed cyclization cascade approach toward highly functionalize

73 the synthesis of such structures by radical cyclization cascade reactions is rare.

74 etic pathways: the multibond-forming polyene cyclizations catalyzed by the yet poorly understood fami

75 dem, microwave-assisted oxyanionic 6-exo-dig cyclization/Claisen rearrangement reaction.

76 ly catalyzes the highly selective 6-endo-dig cyclization, completely reversing the regiochemistry tha

77 nation and diastereoselective Friedel-Crafts cyclization constitute an efficient synthetic route to a

78 Synthesis of bridged scaffolds via Type II cyclization constitutes substantial challenges due to th

79 The degree of GDGT cyclization correlated with growth rate under most condi

80 de product formed through 4-exo-trig radical cyclization could be recycled through an unprecedented t

81 An alkoxycarbonyl radical cyclization-cross-coupling cascade has been developed th

82 chnical issues for converting the FRET-based cyclization/decyclization rates to an equilibrium quanti

83 ds affect these one-pot aza-Michael-addition/cyclization/dehydration reaction sequences.

84 xypropenones, which can also undergo Nazarov cyclization, delineation between competing Nazarov and C

85 rate as well as a one-pot Rieche formylation/cyclization/deprotection sequence to efficiently constru

86 It is shown that consecutive cyclizations do not involve brominated intermediates and

87 that of alpha-RgIA4, demonstrating that the cyclization does not perturb the overall conformation of

88 ve S-alkylation followed by intramolecular N-cyclization enabling the formation of C-S and C-N bonds

89 reduction triggers a regioselective radical cyclization event, followed by anion formation and quenc

90 y-indoles that trigger facile intramolecular cyclization followed by an oxidative quenching step.

91 a Z-selective ring-closing metathesis (RCM) cyclization followed by an oxygen to carbon ring contrac

92 n alkanethiol to an isonitrile moiety, 5-exo cyclization, followed by nucleophilic addition of an alk

93 A one-pot, metal-free, double cyclization for the synthesis of bicyclic 2-pyridones as

94 rature atroposelective intramolecular S(N)Ar cyclizations for sequential CD (8:1 dr) and DE ring clos

95 activated aldehydes followed by alkyne-Prins cyclization, Friedel-Crafts reaction, and final eliminat

96 ls-Alder (IMDA) and hetero-Diels-Alder (HDA) cyclizations from an ambimodal transition state, as well

97 benzylic gem-diboronates, via radical carbo-cyclization/gem-diborylation of alkynes with a high func

98 lowed by azidation, thermal or photochemical cyclization, glycosylation, and final functionalization

99 he proline-catalyzed direct Mannich reaction-cyclization/IBX-mediated site-selective oxidation/NaBH(4

100 tD is competent to perform an intermolecular cyclization in addition to its cognate intramolecular re

101 The results suggest the degree of cyclization in archaeal lipids records a universal respo

102 ne frameworks via thio(seleno)cyanative ipso-cyclization in the presence of ceric ammonium nitrate (C

103 ulations show that the reaction proceeds via cyclization in the triplet excited state to yield a 1,4-

104 are regioselectively favoring the 5-exo-dig cyclizations in all the annulation processes.

105 n selected such as inter- and intramolecular cyclizations, including carba-, oxa-, thia- and oxazacyc

106 Here we show that the average degree of GDGT cyclization increases with doubling time in continuous c

107 Subsequent enantioselective cyclization involving a BOX-ZnI(2)-activated alkyne lead

108 bond protonation, followed by intramolecular cyclization involving the interaction of the carbocation

109 The development of new one-pot sequential cyclizations involving a Vilsmeier-Haack reaction follow

110 tational results supported the idea that the cyclization is a 4pai-electrocyclization and not a 5-end

111 vacine and ellipticine via late-stage D-ring cyclization is described.

112 sized in a modular fashion but also that the cyclization is efficient and amenable to the presence of

113 The final cyclization is incompatible with this mechanism and is f

114 cyclization pathways support that the 5-exo cyclization is preferable.

115 he preparation of indolines by dearomatizing cyclization is presented.

116 the rate controlling step, (b) excited state cyclization is the rate controlling step, and (c) the ra

117 nus not bearing a phenyl ring is because the cyclization is thermodynamically disfavorable, subsequen

118 d in order to undergo further intramolecular cyclization leading to a new class of macrocycle.

119 undergo triflic acid-mediated intramolecular cyclization, leading to benzo[b]fluorenone derivatives v

120 Cyclization linker optimization from library screening p

121 Here, we measured cyclization (looping) and decyclization (unlooping) rate

122 mputations identified a barrierless two-step cyclization mechanism for the formation of 2 upon photoe

123 rins are synthesized by employing the Scholl cyclization method.

124 Catalytic enantioselective Type II-cyclization methods are even rarer.

125 ty obtained through the preferred 5-exo-trig cyclization mode.

126 a radical-polar crossover mechanism, and the cyclization occurs by nucleophilic attack of a convenien

127 Using a stable precursor to start, cyclization occurs via a catalytic controlled process.

128 atalyzed, carbon monoxide mediated reductive cyclization of 1,4-dialkenyl-2,3-dinitrobenzenes.

129 nt-theory investigation of the formation and cyclization of 2'-alkynylacetophenone oxime radical cati

130 of substituent effects on the formation and cyclization of 2'-arylbenzaldehyde and 2'-arylacetopheno

131 ry alcohols and acceptorless dehydrogenative cyclization of 2-aminobenzyl alcohol with ketones throug

132 hrough the iodine-mediated [3 + 2] oxidative cyclization of 2-aminoheteroarenes and isothiocyanates/i

133 We report here the regioselective 6-endo-dig cyclization of [2-(butylselanyl)phenyl]propynols promote

134 oth approaches, the key step is based on the cyclization of a (tris)lithio-triphenylmethane or a (tri

135 effecting a transannular C20-C2 free radical cyclization of a challenging substrate with formation of

136 on of the C-9/C-14 bond by a SmI(2)-mediated cyclization of a keto aldehyde.

137 An intricate radical cyclization of a late stage intermediate followed by an

138 tic strategy also features an intramolecular cyclization of a N-chloroamine to forge the C6-N bond, a

139 The cyclization of a series of nonheterocyclic allenyl aryl

140 that NanA-C(T) catalyzes the regioselective cyclization of a surrogate synthetic substrate, Ant-l-Ky

141 2-trihydro[3]triangulenium cation by cascade cyclization of a tetra-benzyl alcohol precursor in trifl

142 reaction conditions were then applied to the cyclization of a tripeptide and an arodyn analog resulti

143 The reaction proceeds through the cascade cyclization of acylimines (in situ formed) with activate

144 was played by the cobalt-catalyzed oxidative cyclization of alken-5-ol derivatives ("Mukaiyama cycliz

145 yzed enantioselective intramolecular Type II cyclization of alkynes via C-C activation of cyclobutano

146 THF rings is then believed to occur through cyclization of an alcohol/alkoxide to the recently forge

147 Epoxypolyene cyclization of an enantiomerically pure, but geometrical

148 ction conditions, followed by intramolecular cyclization of an intermediate formed after the regenera

149 of 15 R-HETE but also allows oxygenation and cyclization of arachidonic acid to a 15 R-PG endoperoxid

150 monstrated via site-selective intramolecular cyclization of aryl-fused 1,6-diyn-3-ones.

151 /DBU/MS joint system-catalyzed carboxylative cyclization of arylacetylene, arylaldehyde, and arylamin

152 An Ir(III)-catalyzed oxidative cyclization of benzoic acids with propargyl alcohols to

153 Key steps involve the (i) Vollhardt cyclization of bis(propargyl)benzenes with bis(trimethyl

154 A corresponding cyclization of C-phenylnitrile imine 19 can also lead to

155 nt dimerization specifically accelerates the cyclization of cGAMP.

156 triguing observations in the Au(I)-catalyzed cyclization of cyclic and acyclic acetals of alkynylalde

157 Cyclization of DNA with sticky ends is commonly used to

158 An asymmetric hydroarylative cyclization of enynes involving a C-H bond cleavage is r

159 a method for its formation by intramolecular cyclization of ester-tethered enaminones, which can easi

160 MoaA catalyzes an unprecedented 3',8-cyclization of GTP into 3',8-cyclo-7,8-dihydro-GTP (3',8

161 n pathway involves an intramolecular cascade cyclization of homopropargyl sulfonamides to generate a

162 This process is also applicable to the cyclization of internal alkyne-tethered N-propargylic be

163 Cyclization of linear dipeptidyl precursors derived from

164 ation reactions, specifically, a dehydrative cyclization of monoallylic diols for the synthesis of th

165 le as the best precatalyst for the oxidative cyclization of N-alkenylamides into 2-oxazolines.

166 A metal-free oxidative cyclization of N-Boc-acrylamides with (diacetoxyiodo)ben

167 ctional theory and CASPT2 levels now examine cyclization of N-phenylnitrile imine 13 to indazole 17.

168 key step of the synthetic sequence included cyclization of N-protected 2-(azetidin-3-yl)propane-1,3-

169 The observed regioselectivity of the ortho-cyclization of nitroso oxides was explained using theore

170 the utility of the technique for probing the cyclization of non-natural GPA peptides by these powerfu

171 oxime-catalyzed acceptorless dehydrogenative cyclization of o-teraryls was developed.

172 an indium-catalyzed intramolecular 5-exo-dig cyclization of ortho-alkynyl diketopiperazines has been

173 We now report that cyclization of pivaldimino-amides with phosgene in the p

174 s-electrophilic agents and their use for the cyclization of proteins.

175 ) derived reagent (c-PyPA) obtained from the cyclization of pyrophosphate with a reactive diisopropyl

176 ted cascade process was developed, involving cyclization of readily available beta-ketonitriles into

177 These can be described in terms of the cyclization of six {Fe(3)Ln(muOH)(ampd)(2)(Hampd)(2)(PhC

178 ient conditions through tandem oxidation and cyclization of sp(3) C-H bonds under metal-free conditio

179 Sequential cyclization of substrates with ester groups could be ach

180 of the OxyE enzyme in maintaining effective cyclization of such peptides bearing 3,5-dihydroxyphenyl

181 ep of the proposed strategy is base-mediated cyclization of sulfonamide-tethered 5-iodo-1,2,3-triazol

182 Upon cyclization of the Barbier product to lactam and enolate

183 .1.1]hexane 2,2-dioxide) were synthesized by cyclization of the corresponding amino sulfonyl fluoride

184 vealed significant effects of the structural cyclization of the D-A-repeating unit, including more ef

185 the benzazepine scaffold, while spontaneous cyclization of the dipeptide yielded the alternative kin

186 none (E, 70%; Z, 3%); subsequent double-ring cyclization of the E-enone (via Nazarov, electrophilic a

187 n that is required for reductive release and cyclization of the NRPS-tethered dipeptidyl-thioester in

188 A strong acid promotes cyclization of the Os(VI) dioxoglycolate, or its NMO com

189 cysteine residues, resulting in the in situ cyclization of the protein (INCYPRO).

190 d nitrite reagent-mediated diazotization and cyclization of the subsequent 1,2-aryldiamines as the ke

191 NanA are responsible for the regioselective cyclization of the tethered Ant-l-Kyn dipeptide to form

192 An acid-catalyzed intramolecular cyclization of three such indolines gave tetracyclic lac

193 C-terminal residue Ser(33) cleavage, and the cyclization of ToPI1 via a peptide bond between residues

194 trimethylsilyl)amide-mediated intramolecular cyclization of trisubstitued cyclopentane carboxylates b

195 ampestris into a monooxygenase for oxidative cyclization of tryptophans.

196 opy, support a mechanism involving oxidative cyclization of two dienes that determines regio- and dia

197 trary, 2,6-dialkylpyridines were produced by cyclization of unsaturated ketones.

198 omputational data supporting the notion that cyclizations of 3-halopentadienyl cationic intermediates

199 acid catalyst exerts control over asymmetric cyclizations of acyclic ketone-derived trisubstituted ox

200 nds promote highly enantioselective aza-Heck cyclizations of alkenyl N-(tosyloxy)carbamates.

201 Several additional examples of cascade cyclizations of alpha,beta-unsaturated thioesters procee

202 for the reduction of epoxides and for 5-exo cyclizations of suitably unsaturated epoxides.

203 ll as more thermodynamically favorable, than cyclizations of the analogous 3-oxypentadienyl cationic

204 age complex can catalyze oxa-Pictet-Spengler cyclizations of tryptophols and various aldehyde derivat

205 reaction proceeds via a novel Dieckmann-like cyclization pathway.

206 d relative free energies of 5-exo and 6-endo cyclization pathways support that the 5-exo cyclization

207 milar residues in peptide and peptidomimetic cyclizations performed on solid phase.

208 th range of 360-410 nm, whereas the E-isomer cyclization (Phi(c) = 0.006-0.008) and cycloreversion (P

209 isomerization (Phi(ZE) ~ Phi(EZ) ~ 0.30) and cyclization (Phi(c) = ~0.07).

210 We have found not only that the cyclization precursors can be synthesized in a modular f

211 The cyclization precursors were equipped with propargylic OM

212 The cyclization precursors were prepared by a double Kosugi-

213 Unsymetrical cyclization precursors were prepared by two sequential c

214 no benzyl alcohols followed by NHC-catalyzed cyclization proceeding via the imidoyl azoliums under ox

215 The Cp*Ru-catalyzed cyclization proceeds well with both simple alkynyl triaz

216 i-4CR adducts, employing an aromatic radical cyclization process promoted by tetrabutylammonium persu

217 ketimine addition, and Pictet-Spengler-like cyclization processes and affords products in up to 92%

218 onitroalkenes via a cascade Michael addition-cyclization protocol to afford nitrodihydrofurans and hy

219 uinone to the prochiral radical formed after cyclization provides high levels of enantioselectivity a

220 As the iminium ion undergoing the aza-Prins cyclization rapidly isomerized to a planar enamine inter

221 -soluble species, and increased control over cyclization rate.

222 metal-free, simultaneous triple C-C coupling cyclization reaction between phenacyl bromides and indol

223 3-dicarbonyl compounds followed by Conia-ene cyclization reaction in moderate to good yields catalyze

224 detailed computational investigation of the cyclization reaction mechanism suggests facile C-N bond

225 The amination cyclization reaction mechanism was examined employing nu

226 ighly robust one-pot, four-component cascade cyclization reaction of alpha-keto aldehydes, anilines,

227 s the only reagent for the unusual and rapid cyclization reaction to furnish all new carbazole compou

228 tive phase-transfer-catalyzed domino Michael-cyclization reaction with acetylacetone.

229 ucial in the final stage of the head-to-tail cyclization reaction, but the enzyme(s) involved in the

230 rona discharge, solvent-free Borsche-Drecsel cyclization reaction, Katritzky chemistry, and Paal-Knor

231 ormation, and ESI-MS analyses of the ongoing cyclization reaction.

232 ium complex with HFIP which may initiate the cyclization reaction.

233 of hongoquercins using gold-catalyzed enyne cyclization reactions and further derivatization are des

234 wn to catalyze enantioselective tail-to-head cyclization reactions of neryl chloride analogues.

235 is was designed featuring two gold-catalyzed cyclization reactions, specifically, a dehydrative cycli

236 ry centres induce large rate enhancements in cyclization reactions-known as the Thorpe-Ingold effect-

237 Thorough optimization of the activation/cyclization resulted in yields ranging from 15 to 85% fo

238 two-step catalytic asymmetric reduction and cyclization sequence from ketone enolate-derived adducts

239 erization and an amidation/N-acyliminium ion cyclization sequence to furnish four of the five requisi

240 one-pot rhodium catalyzed N-H insertion and cyclization sequence uses diazo compounds to stitch toge

241 C-H alkylation and intramolecular oxidative cyclization sequence.

242 position changes the direction of the ortho-cyclization so that it occurs via the cis/anti form of n

243 d determined the rate of the on-pathway 3',8-cyclization step as 2.7 +/- 0.7 s(-1).

244 d heterochiral cross-coupling with a Bergman cyclization step have been examined.

245 he potential energy surface reveals that the cyclization step is a key step controlling the selectivi

246 Participation of the uracil moiety in the cyclization step is proposed.

247 The final cyclization step was shown to be a transformation amenab

248 strongly supports a radical process for the cyclization step.

249 cyclization, and intramolecular iminium ion cyclization steps.

250 he initial reductive coupling and subsequent cyclization steps.

251 ith less double-bond isomerization and fewer cyclization steps.

252 regioselective gold(I)-catalyzed 6-endo-dig cyclization strategy for the construction of the isocoum

253 A tandem acetylene-activated S(N)Ar-anionic cyclization strategy is presented for the synthesis of c

254 An on-resin cyclization strategy was employed to prepare A5A(1) anal

255 es from o-phenylenediamines via an oxidative cyclization strategy.

256 iodo aryl allenyl ethers initiates a radical cyclization that is followed by intermolecular radical-r

257 After selective hydrolysis and subsequent cyclization, the phosphonate or phosphinate intermediate

258 In Sez-mediated peptide cyclization, the Sec can also be retained, which enhance

259 it becomes potentially competitive with the cyclization to 1 H-diazirines and hence rearrange to car

260 or cesium carbonate, underwent nucleophilic cyclization to afford 4-methylene-3-[(4-nitrophenyl)thio

261 w conditions with a subsequent base-mediated cyclization to afford the desired substituted indoles.

262 Montmorillonite K10 favored cyclization to bicyclononane.

263 t sequence of lactam reduction and aza-Prins cyclization to directly set the final stereogenic center

264 meworks and the base-mediated intramolecular cyclization to establish the spiral quaternary center of

265 es domino imine formation and intramolecular cyclization to form 2-arylcyclopropyl-2,3-dihydroquinoli

266 wed by an aerobic, copper-catalyzed, radical cyclization to form Csp(2)-Csp(2) and O-Csp(2) bonds.

267 e dimethyl acetal, followed by acid-mediated cyclization to generate the iminium precursor that was s

268 l bromide, finally leading to intramolecular cyclization to give a mixture of diastereomers with exce

269 Cyclization to II and III produced submicromolar AR anta

270 oles and rhodium-catalyzed ring-opening, and cyclization to N-difluoromethylated oxazoles and thiazol

271 dation and dehydration occur not only during cyclization to pGlu, but also during other reactions lea

272 of epoxypolyenes-substrates that can undergo cyclization to podocarpane-type tricycles-reveals relay-

273 ilding of the pyrrolo nucleus, and reduction-cyclization to the corresponding diazepine.

274 ondensation with aminoalcohol, and oxidative cyclization to the target pyrrole ring.

275 lis (VRE), and another undergoes spontaneous cyclizations to a cyclopropane-bridge-containing hexacyc

276 e enzymes can catalyse redox-neutral radical cyclizations to produce enantioenriched oxindoles from a

277 s for stereo- and regiochemical transannular cyclizations to synthesize three different indolizidin-2

278 ) chelate; the reaction proceeds via Nazarov cyclization (to form the isocyclic ring), S(E)Ar (to con

279 imethylacetals required for Pomeranz-Fritsch cyclization under sufficiently mild conditions to prepar

280 nyl-5-pentyn-1-ols fail to undergo 6-exo-dig cyclization under the conditions employed.

281 rdeveloped affinities and could benefit from cyclization using a bridging linker sequence.

282 Here, we report an enantioselective radical cyclization using alkyl iodides as precursors to unstabi

283 matically generates, evaluates, and proposes cyclizations utilizing a library of well-established che

284 ed rings through spiroannulation followed by cyclization via C-H activation.

285 The crucial step of the synthesis is cyclization via nonclassical Wittig olefination of resin

286 also catalyse reductive dehalogenations and cyclizations via single electron transfer mechanisms.

287 A novel Co(II) -catalyzed polyene cyclization was developed that is uniquely effective whe

288 The regioselectivity of the transannular cyclization was influenced by amine protection to favor

289 Oxidation-dependent NDGA cyclization was required for the interaction with monome

290 rability of an S(N)Ar-like mechanism for the cyclization was supported by DFT calculations.

291 dimethyl group to promote both stability and cyclization, we found the initial rate of payload releas

292 hermodynamics and kinetics of radical cation cyclization, we provide an explanation for these observa

293 ved from (+)-vince lactam, resulted in 5-exo cyclizations which furnished a series of 2,5-dimethyl-1-

294 zation of alken-5-ol derivatives ("Mukaiyama cyclization"), which is shown to be exquisitely chemosel

295 erization or through a Pomeranz-Fritsch-type cyclization with a final intramolecular Heck reaction.

296 E upon Knoevenagel condensation and Nazarov cyclization with a ring D constituent as demonstrated in

297 ulfonic acid (PTSA)-catalyzed intramolecular cyclization with aldehydes has been developed.

298 Rather, a cyclization with subsequent hydrogen abstraction occurre

299 des inter- and intramolecular buta-1,3-diyne cyclizations with the formation of iodoethynylheterocycl

300 ASA can undergo intramolecular cyclization, yielding an equilibrium with the resulting