ライフサイエンスコーパス: cyclize

1 r its derivatives (X = H, OH; X = H, OAc) to cyclize.

2 ed, but this species could not be induced to cyclize.

3 the 5'-activated 2'-amino nucleotides do not cyclize.

4 linear substrate so that the two ends can be cyclized.

5 f which are heterochiral and/or N-C backbone-cyclized.

6 tion of a 2-(indol-1-yl)phenyl radical which cyclizes.

7 ducts in the absence of added ligand and the cyclized 7- and 8-substituted-imidazo[1,2-a]pyrrolo[2,3-

8 subsequent sequential oxidation reaction of cyclized 7-iodo-12-phenylindeno[2,1-alpha]phenalene (ipp

9 This study exemplifies a novel approach to cyclize a Type II beta-turn linear peptide and provides

10 e that sortase A can successfully be used to cyclize a variety of small disulfide-rich peptides, incl

11 te and act in a novel second transformation, cyclizing ALA-CoA to C(5)N.

12 nd, and finally protonation of the resulting cyclized alkyl complex by hydrazide to release the hydro

13 le of the (99m)Tc(CO)3-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone derivative

14 ring size of the radiolabeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone (alpha-MSH

15 perties of the (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptides.

16 design of a novel radiolabeled lactam bridge-cyclized alpha-MSH peptide for melanoma imaging and trea

17 A transition metal rhenium-cyclized alpha-MSH peptide, ReO[Cys(3,4,10),d-Phe(7),Arg

18 Zn(II)] and their independently synthesized, cyclized analogs have been prepared to investigate their

19 ptide backbone methylation or preparation of cyclized analogues based on pyrrolidine were evaluated a

20 The manifold applications for cyclized analogues of the aromatic amino acids Phe, Tyr,

21 (OxyK and OxyN) are necessary to completely cyclize and aromatize the amidated tetracyclic aglycon.

22 de chain of an l-dopa precursor was shown to cyclize and form a proposed indole structure in C. neofo

23 A piperacillin-BSA adduct with cyclized and hydrolysed forms of the hapten bound to eig

24 tals in the presence of 1.5 mM Ca(2+) is not cyclized, and two calcium ions are observed in the 2.9 A

25 Nature oligomerizes, cyclizes, and then oxidizes gamma,gamma-dimethylallyl py

26 In situ hydrogenation of cyclized anhydrobase intermediates afforded 4-substitute

27 covalent networks (HDCNs), which can further cyclize at high temperatures, producing poly(hexahydrotr

28 orresponding 6-oxo analogue is well-known to cyclize at N7.

29 domized 6-mer library in which peptides were cyclized at two ends through a cysteine-AcrK linker, we

30 re planar complex that spontaneously Bergman cyclizes at ambient temperature to give the crystalline

31 position of the core GDGT lipid, while GrsB cyclizes at the C-3 position, suggesting that cyclizatio

32 Their end-to-end cyclized backbone that enhances molecular stability is a

33 Cyclized beta-lactamase was soluble even after heating a

34 p to a kDelta process involving formation of cyclized beta-silyl carbocation intermediates for electr

35 This isomerization suggests that the cyclized beta-silyl cation can isomerize and then reopen

36 B3LYP/6-31G* computational studies show only cyclized beta-silyl cations as energy minima.

37 rom the W4A9 sequence (Ac-ICVWQDWGAHRCT-NH2, cyclized between C2 and C12), based on structural, compu

38 The surface peptides were cyclized between their N-terminal amine and a carboxyl g

39 rate-analogue plasmin inhibitors, which were cyclized between their P3 and P2 side chains, provided a

40 k of coordination to purine, Y. pestis AC-IV cyclizes both ATP and GTP.

41 P450 (P450) enzymes that are responsible for cyclizing bound peptides.

42 nverted to regiospecific vinyl triflates and cyclized by a palladium-catalyzed intramolecular arene-v

43 e precursor nerylneryl diphosphate, which is cyclized by an unusual plastidial terpene synthase (LfTP

44 ynylphenyl propargyl ethers were efficiently cyclized by potassium tert-butoxide to the corresponding

45 se potent Dyn A analogues are the first ones cyclized by RCM.

46 The ligand strands can be cyclized by ring-closing olefin metathesis to form a mol

47 -(Cbz-aminoacyl)thiosemicarbazides 3a-c were cyclized by treatment with sulfuric acid to give 1,3,4-t

48 tones, and "reducing" ARO/CYCs, which act on cyclized C9 reduced poly-beta-ketones.

49 esents the first example of a fluorescent N1-cyclized cADPR analogue and is a new pharmacological too

50 pondingly reduced or increased production of cyclized carotenoids, which would be expected if CruP wa

51 Briarellins, a subset of C2-C11 cyclized cembranoids, were proposed to contain a C3-C14

52 acrocyclization-based strategies to complex, cyclized cembranoids.

53 tic behavior as a result of their finite but cyclized chain structures.

54 l. report on their successful synthesis of a cyclized competitor peptide that blocks the binding of F

55 The findings permitted development of a cyclized competitor peptide that demonstrated strong inh

56 cyclic peptides that are small, head-to-tail cyclized, composed of proteinogenic amino acids and lack

57 mproved the ligand efficiency/potency of the cyclized compound relative to its acyclic analogue.

58 Our data show that cyclized Crp4 can be biosynthesized by using this approa

59 We present here the biosynthesis of backbone-cyclized Crp4 using a modified protein splicing unit or

60 We show that cyclized CRRETAWAC fully displaced MSC adhesion to FN, w

61 creased biological activity of a Diels-Alder cyclized (DAC) RGD peptide.

62 results indicate the potential for backbone-cyclized defensins in the development of novel peptide-b

63 inobutyryl to the Cl-ACC product but did not cyclize delta- or epsilon-chloroaminoacyl-S-CmaD substra

64 This highly methylated cyclized depsipeptide exhibited an unprecedented selecti

65 as UV irradiation generated the two expected cyclized diastereomers.

66 Cyclized dihydrofolate reductase was similarly resilient

67 ear-quantitatively generates the cis-Bergman-cyclized, diiodo product 3 ((31)P: delta = 41 ppm, J(Pt-

68 ted CH(2)=CHCH(2)CH(OR)(2) acetals, and they cyclize divinyl ethers to analogous cyclic acetals.

69 resilience even at 100 degrees C, where the cyclizing domains themselves were unfolded.

70 properties of (111)In-labeled lactam bridge-cyclized DOTA-[X]-CycMSH(hex) {1,4,7,10-tetraazacyclodod

71 -Arylthioketones and 2-arylaminoketones also cyclize effectively under these conditions.

72 precursors ranging from 3 to 15 amino acids cyclize effectively under this photoredox method.

73 -aryl alpha-diazo ketones under Rh catalysis cyclize efficiently to the corresponding cyclohexanones.

74 Chemically activated short oligonucleotides cyclize efficiently, which severely impairs polymer grow

75 a a delocalized 2-aza-pentadienyl anion that cyclizes either by a suprafacial electrocyclic mechanism

76 use to macrocyclize peptides, suggesting new cyclizing enzymes await discovery.

77 lience, we established the SpyRing approach, cyclizing enzymes by sandwiching between SpyTag and SpyC

78 sed in Escherichia coli, and demonstrated to cyclize farnesyl diphosphate, yielding beta-selinene as

79 e in CD38, Thr-221, is shown to disfavor the cyclizing folding of the substrate, resulting in NADase

80 CmaC will not cyclize free gamma-chloro amino acids or their S-N-acety

81 yclotides but are biosynthetically unable to cyclize from their precursors.

82 enones is a peri-fused tricyclic ring system cyclized from a linear polyketide precursor via an unres

83 udied in cyclic peptides whose backbones are cyclized from head to tail, like the membrane permeable

84 cal properties of lariat peptides, which are cyclized from one of the termini onto a side chain, have

85 In vivo, systemic delivery of cyclized GACRETAWACGA linked to (DSS)6 to allow delivery

86 CmaC could cyclize gamma,gamma-dichloroaminobutyryl to the Cl-ACC p

87 ptor binding, we have engineered peptides by cyclizing gamma-MSH using a thioether bridge.

88 ot Euryarchaeota, are the dominant source of cyclized GDGTs in open ocean settings, addressing a majo

89 Cyclized GDGTs increase membrane packing and stability,

90 on of the resulting adducts 3 to provide the cyclized gem-difluoromethylenated diquinanes 4 as a mixt

91 ay, an isomerocyclase that can rearrange and cyclize geranylated indolenine (2) to a previously unkno

92 Post-growth excitation of fully cyclized GNRs induces cleavage of sacrificial carbonyl g

93 that monolayer protection is accomplished by cyclized gold(I)-thiolate tetramers on the gold core sur

94 s are best representatives of this family: a cyclized heptapeptide (called CyRP-71) and a linear octa

95 properties of (99m)Tc-labeled lactam bridge-cyclized HYNIC-linker-Nle-CycMSHhex (hydrazinonicotinami

96 CCAT), separated by a C-terminal spacer to a cyclized IGF1 peptide analog (d-Cys-Ser-Lys-Cys), for IG

97 allylanilines and 4-pentenylarylsulfonamides cyclize in high yield and with good enantioselectivity,

98 3S-epoxy-9Z,15Z-octadecadienoic acid did not cyclize in the presence of PpAOC1; however, when bound t

99 ne precursor, farnesyl diphosphate (FPP), is cyclized in an Mg(2+)-dependent reaction catalyzed by th

100 ng terminal as well as internal alkynes were cyclized in high to excellent yields within 2-24 h under

101 lyl diazoacetate substrates were efficiently cyclized in high yields with up to 99% enantiomeric exce

102 Several 4-aryl pentenoic acids were cyclized in the presence of 0.1 equiv of (DHQD)(2)PHAL,

103 Aminoalkenes are catalytically cyclized in the presence of cyclopentadienylbis(oxazolin

104 afforded a chalcone that was deprotected and cyclized in the presence of sodium acetate in refluxing

105 beta to the protonated -CN group to form the cyclized intermediate 12, which tautomerizes to its most

106 Finally, loss of iodoarene from the cyclized intermediate can proceed by either ligand-coupl

107 to correct the ring topology of incorrectly cyclized intermediates and products, suggesting that the

108 Orn and Dab readily cyclize into lactams, while Dab and Dpr condense less ef

109 F(3)-pentenynes are further intramolecularly cyclized into CF(3)-bicyclic dihydroanthracene derivativ

110 In the last step, they were conveniently cyclized into spirooxaphospholenes with one equivalent o

111 e enamines generated in this reaction can be cyclized into substituted indoles employing copper catal

112 zoic acid and a beta-hydroxy amino acid that cyclizes into the beta-lactone during product release.

113 Substrates, bearing axial chirality, can cyclize intra- or inter-molecularly with concomitant tra

114 could further react with hydrazoic acid and cyclize intramolecularly to provide 5-aminotetrazoles in

115 te 2-chloroquinolines in situ, which further cyclized intramolecularly with nitrogen or sulfur atom v

116 r that is responsible for the synthesis of a cyclized isocyano derivative of tyrosine.

117 n to synthesize the heptaketide backbone and cyclize it into the angular, hemiketal-containing naphth

118 Although the potential of such cyclized/knot polymer architectures is far from being fu

119 ing how RDRP has led to the formation of new cyclized/knotted polymer structures.

120 Paenicidin A is a highly cyclized lantibiotic, containing six lanthionine and met

121 ynthesis of a macrocyclic PROTAC by adding a cyclizing linker to the BET degrader MZ1.

122 y for the rapid production and evaluation of cyclized loops.

123 e polyketide precursor and the corresponding cyclized macrolactone, were also synthesized.

124 C(beta) bond in the Tyr-67 side chain in the cyclized Met-66-Tyr-67-Gly-68 tripeptide.

125 e catalytic differences and the mechanism of cyclizing NAD, the crystal structure of a stable complex

126 The cyclized NDGA analogs may serve as a platform for the de

127 Further, cyclized NDGA reduced alpha-synuclein-driven neurodegene

128 s of directly reduced, cyclized/reduced, and cyclized/non-reduced products depend not only on the rea

129 1) the ratio of cyclized/reduced products to cyclized/non-reduced products depends on the ability of

130 /reduced products and iodides giving largely cyclized/non-reduced products.

131 bolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadien

132 ty relationships of a series of rhenium (Re)-cyclized octreotide derivatives are described.

133 A branched acyclic precursor was cyclized off-resin and then globally deprotected to obta

134 ed to prepare branched precursors which were cyclized off-resin to obtain the target peptides in good

135 me to diffuse out of the solvent cage and to cyclize onto a pendant olefin.

136 However, iminyl radicals did cyclize onto indoles, enabling indolopyridines to be pre

137 wing to the ease with which the C(15)-(S)-OH cyclized onto the epoxide of intermediate 50.

138 The alcohol then cyclizes onto an aldehyde, resulting in the elimination

139 ion of a copper carbenoid intermediate which cyclizes onto the adjacent carbonyl group to give a reac

140 l catalytic cycles supports oxidation of the cyclized Os(IV) THF-diolate intermediate to the correspo

141 ring closure, the oxazolidinone ring and the cyclizing pentadienyl cation are distorted from coplanar

142 in a rodent model of cast nephropathy, this cyclized peptide construct served as an effective inhibi

143 In animal studies, this cyclized peptide was capable of reducing cast formation

144 The N- to C-terminus amide cyclized peptide with one d-amino acid (k) displayed hig

145 As this procedure generates side chain-cyclized peptides bearing a bis-triazole linkage, it is

146 tion of libraries of disulfide-rich backbone-cyclized peptides to quickly perform structure-activity

147 Thus, 17 cyclized peptides were synthesized by solid phase click

148 e of 2F5 than sera elicited with flexible or cyclized peptides, a resemblance heightened by heterolog

149 utilization of multicomponent reactions for cyclizing peptides by either their termini or side chain

150 lent linkage of the N and C termini, and the cyclized pilin integrates into the inner membrane (IM) a

151 articles with sulfur-doped graphene and with cyclized polyacrylonitrile to provide a robust nanoarchi

152 corporation of 1D silicon nanowires into the cyclized-polyacrylonitrile-based electrode-architecture

153 r metabolism and 6-deoxyerythronolide B (the cyclized polyketide precursor to erythromycin) productio

154 t the design and synthesis of new 3D "Single Cyclized" polymeric gene vectors with well-defined compo

155 Circular proteins, defined as head-to-tail cyclized polypeptides originating from ribosomal synthes

156 The fully cyclized primary products then are converted to various

157 by I(-) is on the reaction trajectory to the cyclized product 5.

158 egioselective 6-endo cyclization to afford O-cyclized product in the presence of Au(I)/AgNO3 and N-cy

159 product in the presence of Au(I)/AgNO3 and N-cyclized product in the presence of Au(I)/AgOTf under a

160 support the mechanistic conclusion that the cyclized product is formed via an intramolecular [3,3]-s

161 as less decomposition, and the yields of the cyclized product were much higher, but only for substrat

162 bability, deduced from the relative yield of cyclized product, can be used in conjunction with statis

163 ilic nitrogen atom and a decreased amount of cyclized product.

164 bon resulting in the formation of 6-endo-dig cyclized product.

165 , which leads to the formation of 6-endo-dig cyclized product.

166 ing good regio- and stereospecificity in the cyclized product.

167 The first method (A) yields the cyclized products after only 20 min of microwave (MW) he

168 her showed correlations between the yield of cyclized products and the Hammett sigma(Para)(+) paramet

169 The ability of the iodides to provide cyclized products can be largely restored by adding base

170 nitrogen atom enhanced the stability of the cyclized products compared to N-alkyl- N-aryl-beta-enami

171 sponding acrylate esters 1 and the yields of cyclized products compared to the calculated rate consta

172 )-Hexp (C), it has been shown to provide the cyclized products exclusively.

173 The aromatic 1,6 eneyne (8) gave cyclized products in 78% yield under catalytic condition

174 The electrochemical conversion of COE to cyclized products is complete in a few minutes, in contr

175 in the former, facilitating the formation of cyclized products not observed for Rh.

176 mogeneous reaction (C') between oxidized and cyclized products of DA and NE and drops below that of D

177 the acid counterion is incorporated into the cyclized products providing an overall aminotrifluoroace

178 ylic alcohols as initiators gave the desired cyclized products, and in neat HFIP, a tricyclization re

179 alcogenide species affected the formation of cyclized products, whereas diorganyl diselenides gave hi

180 oups can all react to give the corresponding cyclized products.

181 , resulting in the regioselective 6-endo-dig-cyclized products.

182 ing and leads to the formation of 5-endo-dig cyclized products.

183 tion was completely eliminated to yield 100% cyclized products.

184 ive angularly versus linearly fused azaacene cyclized products.

185 biological synthesis of circular or backbone-cyclized proteins and peptides.

186 anslationally modified proteins and backbone cyclized proteins.

187 the cell lysate, to drive aggregation of non-cyclized proteins.

188 ollowed by hydrolysis delivered benzylically cyclized pyridines in good yield.

189 ated hydrazide and a Pt-alkyl complex of the cyclized pyrrolidinone (20 for N-phthalimido).

190 For epinephrine, the quinone cyclizes quickly and adrenochrome formation dominates, b

191 re analyzed, and the nature of the resulting cyclized radical cation intermediates was characterized.

192 Transfer of an H* back to the metal from the cyclized radical results in a cycloisomerization.

193 ramolecularly to a double bond, generating a cyclized radical.

194 The Glu cyclized readily to pyroGlu.

195 ry precursors, with chlorides giving largely cyclized/reduced products and iodides giving largely cyc

196 into two different effects: (1) the ratio of cyclized/reduced products to cyclized/non-reduced produc

197 The ratios of directly reduced, cyclized/reduced, and cyclized/non-reduced products depe

198 ylation of the carbonyl oxygen preceding the cyclized residue.

199 interfering RNA silencing or treatment with cyclized Retro-2 strongly decreases AAV2 transduction an

200 obes show integrin mechanical preference for cyclized RGD over linear RGD peptides.

201 on or on-resin results in side chain-to-tail-cyclized RGD peptides, for example, with biaryl moieties

202 ion dominates, but for dopamine, the quinone cyclizes slowly and the back reaction prevails.

203 ini of recombinant monoclonal antibodies can cyclize spontaneously to pyroglutamate (pE) in vitro.

204 squalene-hopene cyclase protein (Shc), which cyclizes squalene to the basic hopene structure, resulte

205 It removes the 14alpha-methyl group from cyclized sterol precursors by first forming an alcohol,

206 lyst productivity in RCM, even for a readily cyclized substrate.

207 eld and 99% ee of epoxy alcohols rather than cyclized tetrahydrofuran compounds could be obtained in

208 ramolecular Heck coupling has been chosen to cyclize the 14-membered macrocycle.

209 Our attempts to cyclize the isolated and purified butenoatediazeniumdiol

210 cular assembly (1) is shown to catalytically cyclize the monoterpene citronellal and two homologues.

211 ons unmasked the thioester functionality and cyclized the depsipeptidic macrocycle.

212 n that swings between T1 and T2a/T2b with C3 cyclizing the chain when it reaches the full length.

213 ed that VrtK is the sole enzyme required for cyclizing the geranyl moiety.

214 ort peptides out of a precursor protein, and cyclizes these peptides in vivo and in vitro.

215 Formation of cyclized THF rings is then believed to occur through cyc

216 the hexa-peptide beta-hairpin loop from AGRP cyclized through a DPro-Pro motif.

217 echnique in which its displayed peptides are cyclized through a proximity-driven Michael addition rea

218 The resultant products can be further cyclized through nucleophilic displacement of suitable l

219 methyl acetals of (E)-2-alkylcinnamaldehydes cyclize to 1-methoxy-2-alkyl-1H-indenes in good-to-high

220 2+4] cycloadducts and borane adducts, and to cyclize to 1H-diazirenes of the type 24 in mildly exothe

221 f 1,4-diazahexa-1,3,5-trienes, which rapidly cyclize to 2,2-diaryl-1-sulfonyl-1,2-dihydropyrazines.

222 ence of a carbodiimide-functionalized resin, cyclize to benzazoles with the safe removal of one equiv

223 lpha-peroxy malononitrile species, which can cyclize to dioxiranes that can monooxygenate malononitri

224 paration over a series of 10 constructs that cyclize to form 862-bp minicircles yielded positive and

225 The resulting adducts spontaneously cyclize to form harmful etheno lesions.

226 on-semialdehyde (ACMS), can nonenzymatically cyclize to form quinolinic acid, the precursor for de no

227 The catecholamine quinone may cyclize to form the absorbing product, or it may be redu

228 ular 6-exo or 7-endo attack to a double bond cyclize to give aliphatic radicals, which react along th

229 and tosylamide pronucleophiles were found to cyclize to give either five- or six-membered ring nitrog

230 eading to benzylpalladium intermediates that cyclize to give indenylsilanes through carbopalladation

231 of acyclic intermediates, which subsequently cyclize to give tetrahydroindolizines (stepwise 1,3-dipo

232 rescein dyes, coupled with their tendency to cyclize to nonfluorescent configurations, precludes thei

233 lu, and pGlu, we found that free Gln and Glu cyclize to pGlu in the electrospray ionization source, r

234 n proteins or peptides have been reported to cyclize to pyroglutamic acid (pGlu) during liquid chroma

235 azide precursor, was found to spontaneously cyclize to singlet 4-fluoro-2,1-benzisoxazole.

236 defined 3-aminopropyl mesylates, which were cyclized to 1,2,3,4-tetrasubstituted 3-chloroazetidines

237 halides furnishes intermediates that can be cyclized to 1,2-disubstituted indoles in moderate to hig

238 Compound 1 is first cyclized to a tricyclene core ring structure analogous t

239 was the first intermediate detected, and it cyclized to a tricyclic adduct and its conjugate acid.

240 chlorides can be ionized, stereospecifically cyclized to an array of complex bromocyclic scaffolds, o

241 upling yields alpha-aryl ketones that can be cyclized to benzofurans, and it enables access to eupoma

242 Three rotator-forming linkers were cyclized to form a rigid cyclotriveratrylene (CTV) stato

243 s introduced at the N terminus, which can be cyclized to form pyroglutamate in mammalian cells, the I

244 olyl alpha-diazocarbonyls can be selectively cyclized to give six distinct products through the caref

245 his precursor is furthermore chlorinated and cyclized to merochlorin A and isomeric merochlorin B by

246 Substrates with o-bromo tether further cyclized to pentannulated hydroquinolines through an iso

247 The linear homochiral dimers cyclized to produce the same cyclic homochiral diastereo

248 The ratio of cyclized to solvolysis products decreases with the incre

249 Free NH 3,3-diarylacrylamides are cyclized to substituted 2-quinolones in the presence of

250 ions, the reaction outcome can be tuned from cyclized to sulfur oxidation products.

251 affolds, which are subsequently oxidized and cyclized to the corresponding dibenzo[b,e]iodininium sal

252 ted, and carbon-based substrates are readily cyclized to the corresponding hetero- and carbocycles wi

253 a stereodefined allene, which could then be cyclized to the corresponding stereodefined spiro produc

254 s via Suzuki cross-coupling and subsequently cyclized to the corresponding triphenylenes utilizing th

255 gamma-chloroisoleucyl intermediate which is cyclized to the final product by KtzA without redox part

256 carbonyl or a functionalized alkyne, can be cyclized to the pyrrolodiketopiperazine by protic or gol

257 to form acyloximes which can be oxidatively cyclized to yield ioxazoles.

258 The intermediate cyclizes to afford valuable 3,3-disubstituted benzofuran

259 n to o-biphenylylcarbene (o-BPC), which then cyclizes to FL.

260 ylamine (DPA) attached to an aldehyde moiety cyclizes to form a pyridinium-fused heterocycle.

261 4,5-dihydroxy-2,3-pentanedione (DPD), which cyclizes to form AI-2.

262 ch case, the more nucleophilic pendant amine cyclizes to give a benzofused saturated heterocyclic 5-

263 of a tethered electrophile the alkyllithium cyclizes to produce a spiro compound, again with inversi

264 The resulting ketenimmonium cation then cyclizes to produce naphthyl cation, which rapidly react

265 an open-chain intermediate that subsequently cyclizes to produce the tetrazole nucleus.

266 ecadepsipeptidyl intermediate, which it then cyclizes to produce valinomycin.

267 ommon N-hydroxysulfenamide intermediate that cyclizes to release a masked fluorophore leading to fluo

268 ition 4 in 5, zwitterion 17 is formed, which cyclizes to stable naphthofuran photoproducts 9-12.

269 The resulting pi-allyl intermediate cyclizes to the products by an intramolecular allylic al

270 were ineffective due to chemical instability cyclizing to form a unique diazo-imine.

271 Cyclized Trp-cage is remarkably stable and afforded two

272 This system was also used to cyclize two terminal alkynes and a cyanamide to afford a

273 t, Z,E- and Z,Z-macrocyclic lactones did not cyclize under similar reaction conditions.

274 the analogous bis-ene substrate could not be cyclized under any reasonable conditions.

275 The Ugi adducts were intramolecularly cyclized under basic conditions through the sequential n

276 mann cross-coupling reaction, is reductively cyclized under conventional conditions to give 6,7,8,9-t

277 uted 2-alkyn-1-one O-methyl oximes have been cyclized under mild reaction conditions in the presence

278 "Stapled Peptides" are cyclized using an all-hydrocarbon cross-linking strategy

279 ning two cysteine residues can be stapled or cyclized using homobifunctional allylic carbonate reagen

280 nes whereby simple prenyl-derived chains are cyclized using radical, rather than cationic, reaction p

281 s was observed for either native Crp4 or its cyclized variants.

282 eptide with the Trp-cage fold, we prepared a cyclized version of this motif.

283 activation barriers, and the latter carbenes cyclize very easily to 2 H- and 3 H-indazoles, from whic

284 ochiral twisted tetrachloroperylene monomers cyclized via a cooperative reaction, forming the homochi

285 minimal PKSs produced nonfungal polyketides cyclized via different regioselectivity, whereas the fun

286 peptide sequence, Ac-C(FKFE)(2)CG-NH(2), was cyclized via disulfide bonding of the flanking cysteine

287 to 2,3,4,5-tetra-O-alkyl-dialdoses that were cyclized via the benzoin reaction promoted by a triazoli

288 ly of the vir-T4SS composed of processed and cyclized VirB2 (major subunit) and VirB5 (minor subunit)

289 )) help rationalize why the lactone does not cyclize whereas the ether does.

290 yclizations, syn diastereomers were prone to cyclize, while anti isomers were not.

291 ide in THF-H2O led to bromohydrins that were cyclized with Amberlite IRA 400 HO(-) to yield the serie

292 es were encoded by phage display, chemically cyclized with an azobenzene linker, exposed to UV light

293 Several Ueno-Stork-type precursors cyclized with excellent diastereocontrol in good yields.

294 llenyl sulfinimines can be stereoselectively cyclized with hexamethylditin under palladium catalysis

295 l compound prepared with d-Ser predominantly cyclized with the (1 S,2 S)-2-aminocyclohexanecarboxylic

296 veral peptides bound with high affinity when cyclized with the azobenzene linker, and their affinity

297 s verified that the backbone of 4 was indeed cyclized with the expected regioselectivity.

298 anslocation even when UbcH10 is artificially cyclized without a free terminus.

299 a-ketone intermediates are regiospecifically cyclized, yielding molecules with defined cyclization pa

300 The partially cyclized ZDI is also separated as a minor product.