ライフサイエンスコーパス: cycloaddition

1 and highly diastereoselective nitrile oxide cycloaddition.

2 in promotion of the unprecedented formal 1,4-cycloaddition.

3 line hybrids were synthesized by 1,3-dipolar cycloaddition.

4 lpyrene by the copper-catalyzed azide-alkyne cycloaddition.

5 proved protocol for Cu-catalyzed 1,3-dipolar cycloaddition.

6 of eriobrucinol via a photochemical [2 + 2] cycloaddition.

7 n, we report a catalytic, alkylative [3 + 2] cycloaddition.

8 n is believed to be a spontaneous, concerted cycloaddition.

9 fficient driving force for facile (stepwise) cycloaddition.

10 rtion into a propargylic C-H bond or [3 + 2]-cycloaddition.

11 to generate the three-carbon unit for formal cycloaddition.

12 /Z mixtures to be used as substrates for the cycloaddition.

13 [3.2.2] bicycles in a copper-catalyzed [4+2] cycloaddition.

14 ic substitution and as dienes in Diels-Alder cycloaddition.

15 thogonal to the strain-promoted azide-alkyne cycloaddition.

16 chiral cyclohexanones via a catalytic [4+2] cycloaddition.

17 bulky tetrazine substituents accelerate this cycloaddition.

18 synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition.

19 ce of a Knoevenagel condensation and a [4+1] cycloaddition.

20 n what can be viewed as an interrupted [2+2] cycloaddition.

21 eous intramolecular [4+2] hetero-Diels-Alder cycloaddition.

22 is immediately intercepted by a Diels-Alder cycloaddition.

23 rdle in an otherwise energetically favorable cycloaddition.

24 ))-H activation to complete a formal [3 + 2] cycloaddition.

25 addition and copper(I)-mediated alkyne-azide cycloaddition.

26 e diene and dienophile to catalyse the [4+2] cycloaddition.

27 first to alter the mode (N1/N4 vs C3/C6) of cycloaddition.

28 the result of his research into 1,3-dipolar cycloadditions.

29 itronate conjugate addition and formal [4+2] cycloadditions.

30 ly intercepted by dipolarophiles via [5 + 2] cycloadditions.

31 ones that engage tethered alkenes in (3+1+2) cycloadditions.

32 omotes a range of bulk-phase, radical-cation cycloadditions.

33 ty, including insertions, 1,2-additions, and cycloadditions.

34 ed helicenes via Zr-mediated, formal [2+2+n] cycloadditions.

35 formation of two azomethine ylides, [3 + 2]-cycloaddition, 1,3-sigmatropic rearrangement, Michael ad

36 cycloaddition processes will include [2 + 2] cycloadditions, [3 + 2] 1,3-dipolar cycloadditions (with

37 ygenation reaction pathways were the [2 + 2] cycloaddition (60.2%) and ene reactions (39.8%) occurrin

38 emain challenging to prepare by azide-alkyne cycloaddition (AAC, CuAAC, RuAAC) methods and can be sca

39 The net transformation results in a [3 + 2] cycloaddition accompanied by an alkylation of the enoate

40 The combination of electrocyclizations and cycloadditions accounts for the formation of a range of

41 The reaction constitutes a formal [4 + 2] cycloaddition across the two nitrogen atoms (N1/N4) of t

42 f live mice, using bio-orthogonal two-photon cycloaddition and crosslinking of the polymers at wavele

43 hores, is geometrically unfavourable for the cycloaddition and exhibits a highly reversible photoswit

44 lf-reaction of phenylalanine via [2 + 2 + 2] cycloaddition and minimized the formation of 3,5-phenylp

45 tributes to stereoselectivity of 1,3-dipolar cycloaddition and structural features of beta-proline tr

46 The transit from early cycloadditions and alkyne couplings as ring-closing step

47 formation of amides from amines, as well as cycloadditions and conjugate additions with unsaturated

48 d, especially those based on the 1,3-dipolar cycloadditions and Diels-Alder reactions owing to their

49 ble to cyclic allenes beyond the traditional cycloadditions and nucleophilic trappings previously rep

50 high reactivity in many reactions, including cycloadditions and nucleophilic trappings, often generat

51 pyrrolidine rings were synthesized using the cycloaddition, and can further undergo [1,3] N-to-C rear

52 lecular proton transfer, Huisgen 1,3-dipolar cycloaddition, and dehydrogenative aromatization.

53 zed enzymatic pericyclic reactions have been cycloadditions, and it has been difficult to rationalize

54 followed by a 6pai electrocyclization and a cycloaddition are relatively common.

55 n and subsequent stereoselective 1,3-dipolar cycloaddition as key steps.

56 yrrin) facilitate intramolecular 1,3-dipolar cycloaddition as well as C-H amination to furnish 1,2,3-

57 work contributes to the study of 1,3-dipolar cycloaddition, as well as enriches chemistry of cyclopro

58 [2+2+2] cycloadditions, as an alternative path to the Diels-Alde

59 ) is reduced by about 5 kcal.mol(-1), the DA cycloaddition becoming more regioselective.

60 g a cobaltacyclobutane formed from a [2 + 2]-cycloaddition between a cobalt vinylidene and a vinylcyc

61 report a cobalt-catalyzed reductive [5 + 1]-cycloaddition between a vinylcyclopropane and a vinylide

62 The first enantioselective formal [3 + 2] cycloaddition between alpha-isocyanoesters and trifluoro

63 tenes is through an enantioselective [2 + 2]-cycloaddition between an alkyne and an alkenyl derivativ

64 thod features a visible-light-mediated [4+2] cycloaddition between an arene and an arenophile, and su

65 The thermal 6pai aza-Diels-Alder cycloadditions between alpha-oxoketenes, in situ derived

66 ate or efficiency of a heterocyclic azadiene cycloaddition by hydrogen bonding catalysis but also the

67 , and Negishi couplings, addition reactions, cycloadditions, C-H functionalizations, polymerizations,

68 ine via the copper(I)-catalyzed azide-alkyne cycloaddition can increase the conformational stability

69 perma skeleton is a powerful [4 + 2]/[3 + 2] cycloaddition cascade of 1,3,4-oxadiazole 9, which affor

70 d in situ and can undergo the standard aryne cycloaddition chemistry in an enantiospecific manner.

71 eptidic coupling method based on 1,3-dipolar cycloaddition chemistry of azomethine ylides.

72 cluster-surface strain-promoted alkyne-azide cycloaddition chemistry with a strained cyclooctyne, ope

73 ionalizations through, for example, standard cycloaddition chemistry.

74 the noncopper catalyzed azide-alkyne dipolar cycloaddition click reaction between either a library pe

75 utility via the Cu(I)-catalysed azide-alkyne cycloaddition 'click' reaction(18).

76 ehydrogenative coupling, Huisgen 1,3-dipolar cycloaddition (click reaction), hydroheteroarylation, hy

77 Diene isomerization and [4 + 2] cycloaddition, common for conjugated diene systems, were

78 l hydrazide and copper-assisted azide-alkyne cycloaddition conjugation chemistries were employed to g

79 eworks (COFs) results in topological [2 + 2] cycloaddition cross-linking of the pai-stacked layers in

80 y efficient copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reactions on both alkynylated prot

81 ligands in copper-catalyzed azide and alkyne cycloaddition (CuAAC) reactions were studied.

82 eactions using copper-catalyzed azide alkyne cycloaddition (CuAAC) this is not the case.

83 an be used for copper-catalyzed alkyne-azide cycloaddition (CuAAC) without further processing.

84 ted in situ by copper-catalyzed azide-alkyne cycloaddition (CuAAC), providing interpenetrating supram

85 toinitiated copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC)-based networks.

86 etermination by Cu(I)-catalyzed azide/alkyne cycloaddition (CuAAC).

87 nverse electronic demand Diels-Alder (IEDDA) cycloaddition-cycloreversion sequence with s-tetrazines.

88 favours intramolecular photochemical [2 + 2] cycloadditions, displays a nearly irreversible photoswit

89 A broad scope of cycloaddition donors and acceptors participated in the t

90 d and support a reaction mechanism involving cycloaddition followed by a series of rearrangements.

91 thynylbenzenes undergo facile formal [2 + 2] cycloaddition followed by retroelectrocyclization upon r

92 mprising unusual formal [4 + 2]- and [2 + 2]-cycloadditions followed by several ring-opening and ring

93 s key steps are a purpurogallin-type (5 + 2)-cycloaddition, followed by fragmentation, vinylogous ald

94 on the Cu(I)-catalyzed alkyne-azide [3 + 2] cycloaddition for conjugation onto pleuromutilin.

95 lar Diels-Alder reaction and an enone-olefin cycloaddition/fragmentation sequence are then employed t

96 conditions and substrates that decouple the cycloaddition from subsequent steps and allow intercepti

97 eral of the enzymes proposed to perform this cycloaddition have been reconstituted, only pyridine pro

98 However, although enzyme-catalysed [6+4] cycloadditions have been proposed(10-12), they have not

99 Inverse-electron demand Diels-Alder cycloadditions have emerged as important bioorthogonal r

100 escribed the state of the art of 1,3-dipolar cycloadditions-his golden offspring.

101 ddition reactions in general and 1,3-dipolar cycloadditions in particular.

102 PCP)(4) results in an enantioselective [4+2] cycloaddition, in which three new stereogenic centers ar

103 eactions, metalation-ring opening sequences, cycloadditions involving ring-cleavages or rearrangement

104 [1 + 2] cycloaddition is a classical reaction between the electr

105 d azepino-pyrrolizinones via [3 + 2]-dipolar cycloaddition is described.

106 ntaining helicenes via sydnone-aryne [3 + 2]-cycloaddition is described.

107 d Getty showed that the preference for 2 + 2 cycloaddition is due to the necessity for syn-pyramidali

108 The first step of the cycloaddition is rate-determining, and reaction occurs b

109 ly visualized at the submolecular level, the cycloaddition is triggered by ultraviolet irradiation in

110 volysis, Pd catalyzed C-S cross-coupling and cycloadditions) is demonstrated, highlighting both the v

111 t oxygen ene reaction, combined with [2 + 2] cycloadditions, leads to concise, divergent, and redox-e

112 tetrazine followed by a formal retro [4 + 2] cycloaddition loss of a nitrile and aromatization to gen

113 o compounds, and other dipoles), and [4 + 2] cycloadditions (mainly Diels-Alder-type reactions).

114 The alkene-isocyanate cycloaddition method affords beta-lactams from glycals w

115 Owing to distinct cycloaddition modes of these reactive intermediates with

116 the PCP, and thereby the positions at which cycloaddition occurs.

117 iron-catalyzed enantioselective cross-[4+4]-cycloaddition of 1,3-dienes to form substituted cyclooct

118 selectively obtained by photochemical [2+2] cycloaddition of 1,4-bis[2-(4-pyridyl)ethenyl]-benzene w

119 t, the intramolecular iron-catalyzed [2 + 2] cycloaddition of 1,7-octadiene yielded cis-bicyclo[4.2.0

120 For the stereo- and regioselective [2 + 2] cycloaddition of 1-octene to form trans-1,2-dihexylcyclo

121 The first 1,3-dipolar cycloaddition of 2H-azirines with nitrones, a straightfo

122 ing metathesis reaction, and the Diels-Alder cycloaddition of a dienol acetate.

123 A method for the stereoselective [4+2]-cycloaddition of alkenylboranes and dienes is presented.

124 dative bond scission preluding a dioxa-[4+2]-cycloaddition of an aldehyde to an enone and a combined

125 ones has been developed by using the dipolar cycloaddition of an N-alkenylnitrone and an aryne to acc

126 Surprisingly, the [3 + 2] cycloaddition of aryl/vinyl/alkyl azides with the in sit

127 e virtues of the Cu(i)-catalyzed-1,3-dipolar cycloaddition of azides and alkynes (the CuAAC or "click

128 ave been synthesized using a strain-promoted cycloaddition of azides to alkynes (SPAAC) strategy.

129 action proceeds as a sequence of 1,3-dipolar cycloaddition of azomethine ylide generated in situ from

130 -phosphoric acid catalyzed, enantioselective cycloaddition of beta-diketones, beta-keto nitriles, and

131 One-pot metal-free [3 + 2] cycloaddition of CF(3)-substituted alkenes and halogenox

132 n) complexes catalyze the asymmetric [3 + 2] cycloaddition of cyclopropyl ketones with alkenes.

133 ro[3.4]octanes can be accessed via a [2 + 2]-cycloaddition of dichloroketene on a readily prepared ex

134 A method for the three-component cycloaddition of enoates, alkynes, and aldehydes has bee

135 espectively, in turn prepared via metal-free cycloaddition of halogenoximes and propargylic alcohol.

136 isible-light mediated intermolecular [2 + 2] cycloaddition of indoles with alkenes has been realized.

137 An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4' H

138 Cu-catalyzed 1,3-dipolar cycloaddition of iododiacetylenes with organic azides us

139 odimerization and intermolecular cross-[4+4]-cycloaddition of monosubstituted 1,3-dienes is described

140 of 2,3,4,5-tetrasubstituted pyrrolidines via cycloaddition of nitroalkenes and azomethine ylides is r

141 salient (PS) properties triggered by [2 + 2] cycloaddition of olefinic ligands, which is seldom obser

142 tion pathway bifurcation is uncovered in the cycloaddition of oxidopyrylium ylides and butadiene.

143 cyclopropanes by the Au(I)/PPh(3)-catalyzed cycloaddition of propargylic esters and styrene has been

144 the third known example of skewed azaphilic cycloaddition of tetrazine.

145 n rearrangement/Nazarov cyclization, a [4+2] cycloaddition of the formed six- or seven-membered ring-

146 est triafulvene is formed by the barrierless cycloaddition of the methylidyne radical to the pai-elec

147 For the hetero-[6+4] cycloaddition of the pyrrole system with dienes, a wide

148 A stereo- and regioselective 1,3-dipolar cycloaddition of the stable ninhydrin-derived azomethine

149 e present a comprehensive study on the [3+2]-cycloaddition of thiocarbonyl ylides with a wide variety

150 s, formed with high stereocontrol by [3 + 1]-cycloaddition of TIPS-protected enoldiazoacetates with a

151 The process involves 1,3-dipolar cycloaddition of unsymmetrical azomethine ylide resultin

152 used to study such interactions for [2 + 2] cycloadditions of 4-vinylbenzoic acid derivatives on CdS

153 Unprecedented phosphine-catalyzed [4+1] cycloadditions of allenyl imides have been discovered us

154 ich are not accessible by direct 1,3-dipolar cycloadditions of azomethine ylide with frequently used

155 ic intermediates were not found in the [4+2] cycloadditions of both CHT or COT with PTAD and are thus

156 The present work introduces strain-promoted cycloadditions of cyclic allenes under mild conditions t

157 olines that are inaccessible through dipolar cycloadditions of exocyclic cyclohexenones and provides

158 and stereoselective hetero-[6+4] and -[6+2] cycloadditions of heteroaromatic compounds via amino aza

159 indolines through formal [3 + 2] and [4 + 2] cycloadditions of indoles with 1,2-diaza-1,3-dienes (DDs

160 Selectivities in (4 + 2) and (2 + 2) cycloadditions of keteniminium cations with 1,3-dienes s

161 nimides are key intermediates in the thermal cycloadditions of suitable alkenyl-hydrazine derivatives

162 Subsequent regioselective [3 + 2] cycloadditions of the alkynyl-imides (ynimides) generate

163 uccessfully employed to include hetero-[6+2] cycloadditions of the pyrrole system with nitroolefins,

164 mote enantioselective intermolecular [4 + 1]-cycloadditions of vinylidene equivalents and 1,3-dienes.

165 An unprecedented 1,4-cycloaddition (vs 3,6-cycloaddition) of 1,2,4,5-tetrazines is described with p

166 An organocatalytic azide-ketone [3 + 2] cycloaddition (OrgAKC) of a variety of 1-aryl-3-(arylthi

167 Outcomes are exemplified for Diels-Alder cycloadditions, oxidative addition of bonds by transitio

168 lohepta[ b]pyridin-9-one was used as a diene cycloaddition partner to construct [3.2.2] bicycles in a

169 a concerted yet highly asynchronous [4 + 2]-cycloaddition pathway and an attractive CH-pai interacti

170 metathesis and copper-catalyzed alkyne-azide cycloaddition, peptide chemists embraced transition meta

171 r (3D p-POP) using catalyst-free Diels-Alder cycloaddition polymerization followed by acid-promoted a

172 The 1,3-dipolar cycloaddition (Prato reaction) of Y(3)N@I(h)-C(80) and G

173 onditions, this original dearomative (3 + 2) cycloaddition process gives access to a wide variety of

174 This formal [3+2] cycloaddition process provides a highly modular entry to

175 rboxylation through a reversible 1,3-dipolar cycloaddition process.

176 Then, cycloaddition processes will include [2 + 2] cycloadditi

177 in concert with a diverse selection of click-cycloaddition processes.

178 iPr(i) (3) )](3-) ), with RbC(8) via [2+2+1] cycloaddition, produces an unprecedented hexathorium com

179 The cycloaddition product obtained depends on the temperatur

180 monstrate that both the (4 + 3)- and (5 + 2)-cycloaddition products are accessed from the same transi

181 mentation process for (OCP)(-) , rather than cycloaddition products that then decompose with [Th(Tren

182 double nitrogen inversion was found for the cycloaddition products with PTAD.

183 ions behind the traditionally accepted [2+2] cycloaddition proposal.

184 re found to be more suitable for the [2 + 2] cycloaddition, providing better reaction outcomes compar

185 ,3,5-tetrazine displays similarly remarkable cycloaddition rates and efficiencies with amidines (1,2,

186 Whereas the latter reacts at extraordinary cycloaddition rates with strained dienophiles (tetrazine

187 uning of various SNO-OCTs to influence their cycloaddition rates with Type I-III dipoles.

188 The scope of this tandem 1,3-dipolar cycloaddition/rDA reaction was studied with thirteen 7-h

189 ve synthetic steroid, by using a 1,3-dipolar cycloaddition reaction (Prato's protocol) results in the

190 mines participate in this novel hetero-[5+2] cycloaddition reaction and the cycloadducts can be readi

191 As a [2+2] cycloaddition reaction between imines and alkenes, the a

192 cular dynamics simulations indicate that the cycloaddition reaction between ozone and trans-isoprene

193 The hetero-[6+4] cycloaddition reaction concept is extended to include im

194 dium-catalyzed intramolecular carbonyl ylide cycloaddition reaction for the first time.

195 derivatives by tandem beta-azidation/[3 + 2] cycloaddition reaction has been developed under mild con

196 f the transition-metal-catalyzed [2 + 2 + 2] cycloaddition reaction involving all kinds of unsaturate

197 To this end, the Diels-Alder cycloaddition reaction involving cyclopentadiene and the

198 The [2 + 2] cycloaddition reaction is a versatile strategy for const

199 yield through a chelator-accelerated one-pot cycloaddition reaction mediated by copper(I) catalysis.

200 derivatives through the dearomative (4 + 3) cycloaddition reaction of 2-vinylindoles or 4H-furo[3,2-

201 5,5] bicyclic guanidine-catalyzed asymmetric cycloaddition reaction of anthrones.

202 For a typical cycloaddition reaction to occur, however, the installati

203 binary behavior: undergoing a retro-[4 + 2] cycloaddition reaction under high load to form a surface

204 can be visualized "on chip" by a 1,3-dipolar cycloaddition reaction with an alkynyl-modified dye.

205 ooctene as the activator leads to a complete cycloaddition reaction with the antibody-drug conjugate

206 hat were subsequently subjected to a dipolar cycloaddition reaction with trimethylsilyl amino esters.

207 s the transition-metal-catalyzed [2 + 2 + 2] cycloaddition reaction, since it permits the formation o

208 itable motifs for the intermolecular [2 + 2] cycloaddition reaction.

209 no[2,3,4- ij]isoquinolines through a [4 + 2]-cycloaddition reaction.

210 atalysis of the copper-mediated azide-alkyne cycloaddition reaction.

211 hemistry involving a 4-hydroxycoumarin 4 + 1 cycloaddition reaction.

212 ising the overall efficiency or scope of the cycloaddition reaction.

213 ous types of organic reactions, ranging from cycloaddition reactions and sigmatropic rearrangements t

214 Cycloaddition reactions between allenes and partners con

215 nd bio-orthogonal reactions are dominated by cycloaddition reactions in general and 1,3-dipolar cyclo

216 Cycloaddition reactions involving (2+2), (3+2), (3+3), (

217 It is found that the cycloaddition reactions involving those macrocycles havi

218 tution pattern governs both dimerization and cycloaddition reactions is of fundamental interest to pr

219 o form nitrile imines primed for 1,3-dipolar cycloaddition reactions is of widespread utility in chem

220 dipoles and to tune their reactivity toward cycloaddition reactions makes mesoionics an attractive o

221 ort that dinickel complexes catalyze [4 + 1]-cycloaddition reactions of 1,3-dienes.

222 selectivity to triplet excited-state [2 + 2] cycloaddition reactions of alkenes photocatalyzed by the

223 ONHC(6)H(3)( (i)Pr)(2))) were applied in the cycloaddition reactions of aziridines with carbon dioxid

224 The new cycloaddition reactions override the conventional (4+3)

225 Cycloaddition reactions provide an expeditious route to

226 Cycloaddition reactions provide direct and convergent ro

227 as gel columns, which can be reused for the cycloaddition reactions several times.

228 eners to carbonyl compounds, undergo [2 + 2] cycloaddition reactions with different alkynes to genera

229 of products through irreversible 1,3-dipolar cycloaddition reactions with the four nitrones present i

230 s are important intermediates in 1,3-dipolar cycloaddition reactions, and they are also known to unde

231 talytic activity for copper sulfate mediated cycloaddition reactions.

232 sm of both inter- and intramolecular [2 + 2] cycloaddition reactions.

233 upramolecular catalysis for copper-catalyzed cycloaddition reactions.

234 s employing Michael addition and Diels-Alder cycloaddition reactions.

235 viding an unprecedented example of reductive cycloaddition reactivity in the chemistry of 2-phosphaet

236 Initial studies of its cycloaddition reactivity, mode, regioselectivity, and sc

237 This greener approach involves 1,3-dipolar cycloaddition, regioselective ring expansion, followed b

238 intramolecular silyloxypyrone-based [5 + 2] cycloadditions revealed three significant factors impact

239 diastereoselective oxidative dearomatization/cycloaddition sequence and a SmI(2)-mediated C-C couplin

240 sembly of 1,2-oxazine N-oxide by the [4 + 2]-cycloaddition, site-selective C-H oxygenation using a no

241 pentane, by "click" reactions and integrated cycloaddition-Sonogashira coupling reactions.

242 e bioorthogonal strain-promoted azide alkyne cycloaddition (SPAAC).

243 activity toward strain-promoted alkyne-azide cycloaddition (SPAAC).

244 mechanism includes a rare azaphilic [4 + 2]-cycloaddition step between s-tetrazine and intermediate

245 An unprecedented regioselectivity in the cycloaddition step toward the more sterically constraine

246 elective isomerization/stereoselective [2+2]-cycloaddition strategy as well as prominent use of catal

247 e-pot multi-component reaction and a [3 + 2] cycloaddition strategy to append five membered isoxazole

248 A tandem cycloisomerization/[4 + 2] cycloaddition strategy was employed to quickly construct

249 provide the first examples of multicomponent cycloadditions that proceed through C-C bond activation

250 stereochemical information in a Diels-Alder cycloaddition through a point-chirality, axial-chirality

251 ional (4+3) selectivity of aminoallyl cation cycloaddition through a sequence of Pd-allyl transfer an

252 al end group, by means of hetero-Diels-Alder cycloaddition through their inherent terminal thiocarbon

253 ype of pericyclase catalyses [6+4] and [4+2] cycloadditions through a single ambimodal transition sta

254 reagent; and (3) a diastereoselective [3+2]-cycloaddition to assemble the polycyclic structure of a

255 Padwa's nitrile ylide cycloaddition to dimethylfulvene (1978) gave [6+4] and [

256 lts in quantitative dimerization via [2 + 2] cycloaddition to form a [3]-ladderane; irradiation of th

257 ough N-N bond ring opening in a formal [3+3] cycloaddition to form four chiral centers with high ster

258 ol ethers undergo intramolecular 1,3-dipolar cycloaddition to generate stable triazolines; in contras

259 hium salt Li[B(C(6)F(5))(4)] by formal [2+2] cycloaddition to give a boron thiocarbonate-type product

260 oalanines by an enzyme-catalyzed aza-[4 + 2] cycloaddition to give a cyclic-hemiaminal intermediate.

261 erocycles was demonstrated with azide-alkyne cycloaddition to N-bromotetrafluoroethyl 1,2,3-triazoles

262 (1 degrees ) also enabled a thermal Huisgen cycloaddition to proceed regioselectively for the first

263 ures, that catalyses an intermolecular [4+2] cycloaddition to produce the natural isoprenylated flavo

264 st a plausible mechanism proceeding by [2+2] cycloaddition to the silylene complex, which is quite se

265 the inter- and intramolecular [2 + 2] alkene cycloadditions to form cyclobutanes promoted by ((tric)P

266 ailable arylsulfonyl cyanides in Diels-Alder cycloadditions to generate isopyridine cycloadducts that

267 oderately reactive substrates to undergo the cycloaddition under mild conditions, thereby increasing

268 ted benzyl alcohols or undergo a retro [2+2] cycloaddition under thermal conditions to provide the ge

269 A Cu(II) -catalyzed asymmetric 1,3-dipolar cycloaddition using beta-fluoroalkyl alkenyl arylsulfone

270 and imido-sulfur ylides by asymmetric [3+1]-cycloaddition using chiral sabox copper(I) catalysis fol

271 induction are achieved in the intramolecular cycloadditions using a C (2)-symmetric chiral ligand tha

272 An unprecedented 1,4-cycloaddition (vs 3,6-cycloaddition) of 1,2,4,5-tetrazin

273 trisubstituted (3'-methyl-2'-butenyloxy), no cycloaddition was observed.

274 The mechanism of both [4 + 2] and [3 + 2] cycloadditions was investigated and fully rationalized b

275 0 announcement of the concept of 1,3-dipolar cycloadditions was published the year before Alder's stu

276 ective version of the developed higher-order cycloaddition were also undertaken.

277 [6+4] and other 'higher-order' cycloadditions were predicted(7) in 1965, and are now in

278 (80), obtained by regioselective 1,3-dipolar cycloadditions, were elucidated by single crystal X-ray,

279 ng an unprecedented oxopyrrolium Diels-Alder cycloaddition which furnishes a key tetracyclic intermed

280 st location on copper-catalyzed azide-alkyne cycloadditions which drive the self-reproduction of mice

281 of enzymes that catalyse a pericyclic [6+4] cycloaddition, which is a crucial step in the biosynthes

282 They can also self-dimerize via [5 + 3] cycloaddition, which is an oft-reported side reaction th

283 insights into the mechanism of this [2 + 2] cycloaddition, which is initiated by a triplet-triplet e

284 inverse electron-demand Diels-Alder (IEDDA) cycloaddition, which was performed overnight at 37 degre

285 e iridium photocatalyst and allows for [2+2] cycloaddition with a wide range of alkenes.

286 of nitroso oxides, are stabilized by [3 + 2] cycloaddition with acetonitrile to give 1,2,4-oxadiazole

287 combination of Sc(OTf)(3)-catalyzed [4 + 1]-cycloaddition with aza-Michael addition reactions.

288 bornadienes as dipolarophiles in 1,3-dipolar cycloaddition with benzyl azide.

289 approach involves an intramolecular [2 + 2] cycloaddition with concomitant dearomatization of the he

290 ansformation, which resembles a formal [4+2] cycloaddition with concomitant decarboxylation and loss

291 ed aminoallyl precursors for catalytic (3+2) cycloaddition with conjugated dienes via a Pd-aminoallyl

292 rile imine is stabilized, its subsequent 1,3-cycloaddition with N-methylmaleimide remains highly faci

293 Cycloaddition with olefinic dienophiles, under exception

294 significantly more reactive than TCO in the cycloaddition with ortho-benzoquinone.

295 ed in a mild and stereospecific formal [3+1] cycloaddition with simple hydroxylamines, leading to the

296 through inverse electron demand Diels-Alder cycloaddition with subsequent double retro-Diels-Alder r

297 Compound 5 also undergoes cycloaddition with tetrachloro-o-benzoquinone to afford

298 Dihydro-4H-1,2-oxazines when subjected to cycloaddition with the cyclopropane diester afford a tro

299 witterions participate in asymmetric [3 + 2] cycloadditions with a broad range of acceptors, generati

300 oted, with the second-order rate constant in cycloadditions with diazoacetamides exceeding 5.13 M(-1)

301 r number of stereoisomers than that of IEDDA cycloadditions with other dienophiles.

302 [2 + 2] cycloadditions, [3 + 2] 1,3-dipolar cycloadditions (with azides, nitrones, azomethine imines

303 The reaction involves both [2+2] and [2+4] cycloadditions, with the reaction sites aligned into a t