ライフサイエンスコーパス: cyclobutane

1 from the sigma antiaromatic CC framework of cyclobutane.

2 orientation of substituents in the transient cyclobutane.

3 a tethered alkyl halide to form the desired cyclobutane.

4 THPs directly without prior isolation of the cyclobutane.

5 enes as regio- and stereoselective routes to cyclobutanes.

6 he auxiliary guided C-H functionalization of cyclobutanes.

7 embered-ring alkenyl boronate complexes into cyclobutanes.

8 ariety of substituted aryl cyclopropanes and cyclobutanes.

9 furnish a diverse set of highly substituted cyclobutanes.

10 ridyl iridium(III) catalyst, to form bridged cyclobutanes.

11 Cyclobutane-1,2,3,4-tetraone has been both predicted and

12 Cyclobutane-1,2,3,4-tetrone has been both predicted and

13 ave cis,trans,cis-3,4-bis(3,4-dimethylphenyl)cyclobutane-1,2-dicarboxylic acid, 26, in 60% yield.

14 eld and exclusive formation of cis,trans,cis-cyclobutane-1,2-dicarboxylic acids.

15 A previously overlooked building block, cyclobutane-1,3-diacid (CBDA), is introduced to material

16 Main group analogues of cyclobutane-1,3-diyls are fascinating due to their uniqu

17 50 nm irradiation forming both syn- and anti-cyclobutane adducts (17 and 18), which are photoreversib

18 yl group affords the aldehyde-functionalized cyclobutane alpha-truxilaldehyde.

19 he method could distinguish between sites of cyclobutane and 6-4 photoproduct formation.

20 rmal [4 + 2] cycloaddition of donor-acceptor cyclobutanes and aldehydes has been developed.

21 Cyclobutanes and cyclobutenes are important structural m

22 Functionalized cyclobutanes and cyclobutenes are important structural m

23 Consequently, [2+2] cycloadditions to access cyclobutanes and cyclobutenes have been established to b

24 ntioselective [2+2] cycloadditions to access cyclobutanes and cyclobutenes.

25 saged for synthesis of highly functionalized cyclobutanes and cyclobutenes.

26 lowed us to achieve small-size rings such as cyclobutanes and cyclopropanes.

27 arkable for their ability to easily assemble cyclobutanes and other strained ring systems that are di

28 ic solvent, where ring-opened cyclopropanes, cyclobutanes, and homoallyl products are formed.

29 etidines, tert-butyl carbamates (Boc-group), cyclobutanes, and spirocycles.

30 Enantiomerically enriched cyclobutanes are constructed by a three-component proces

31 Structurally diverse cyclobutanes are shown to be conveniently prepared from

32 y led to the development of a novel stepwise cyclobutane assembly by an allylboration/Zweifel olefina

33 The resulting cyclobutane-based products form stereospecifically, quan

34 ein, we report the development of a class of cyclobutane bearing bicyclo[4.2.0]octane mechanophores.

35 a,alpha-tripeptides, consisting of a central cyclobutane beta- or gamma-amino acid being flanked by t

36 des, being superior to peptides containing a cyclobutane beta-amino acid residue.

37 od to predict the backbone folds of designed cyclobutane beta-peptides is based on QM calculations.

38 6 and 32-36 of NPY and PP containing (1R,2S)-cyclobutane (betaCbu) or (1R,2S)-cyclopentane (betaCpe)

39 anism involving a 1,4-biradical derived from cyclobutane bond fragmentation.

40 reoelectronic alignment of the two available cyclobutane bonds with the cyclohexadienone pi-system, w

41 addition reaction to yield the corresponding cyclobutane-bridged dinuclear tetrakis(NHC) complexes.

42 ted from undergoing recombination to yield a cyclobutane by the planarity of the amide substituent.

43 The synthesis of unsymmetrical cyclobutanes by controlled heterodimerization of olefins

44 eta-unsaturated ketones to the corresponding cyclobutanes by using a dual-catalyst system consisting

45 natural products using the first example of cyclobutane C-H arylation.

46 vinyl boronates can be employed, and chiral cyclobutanes can be accessed with high levels of stereoc

47 he bond that extends to the less substituted cyclobutane carbon for 13.

48 , tri-, and tetramers) of cis-2-(aminomethyl)cyclobutane carboxylic acid, a gamma-amino acid featurin

49 A cyclobutane (CB) mechanophore is used as a mechanical ga

50 ng pattern arising from the cyclopropane and cyclobutane CC framework response to a perpendicular mag

51 ramolecular [2 + 2] cycloaddition leading to cyclobutanes competes advantageously.

52 heterocycles that collectively afford fused cyclobutane containing scaffolds that offer unique prope

53 A series of cyclobutane-containing polymers (CBPs), namely poly-alph

54 st direct strategy to build tetrasubstituted cyclobutanes, core components of many lead compounds for

55 d synthesis of cyclopropanes, cyclopropenes, cyclobutanes, cyclobutenes, and their corresponding hete

56 , epsilon-, and zeta-) or cyclic structures (cyclobutane, cyclopentane, and cyclohexane) to improve t

57 carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cyclohept

58 allowed for the synthesis of enantioenriched cyclobutanes, cyclopentanes, indanes, and six-membered N

59 ical shifts of cyclopropane (delta 0.22) and cyclobutane (delta 1.98) which are shifted upfield and d

60 al route for the synthesis of functionalized cyclobutane derivatives starting from functionalized nor

61 The possibility of retro-PCA of the obtained cyclobutane derivatives to give the starting dyes was sh

62 ds only rctt isomers of bis-crown-containing cyclobutane derivatives.

63 tor are reported that furnish aminoborylated cyclobutane derivatives.

64 Cyclobutanes derived from the dimerization of cinnamic a

65 affords consistent formation of predictable cyclobutane diastereomers.

66 e syntheses feature a new preparation of cis-cyclobutane dicarboxylates from commercially available c

67 NOE NMR data are consistent with a cis-anti cyclobutane dimer between the 3'-sides of T2 and T7 in a

68 Cyclobutane dimer photolyases are proteins that bind to

69 idine to produce the corresponding htt r-ctt cyclobutane dimer, and we present (1)H NMR analysis of t

70 diation at the main absorption band leads to cyclobutane dimers (T<>Ts) and (6-4) adducts via differe

71 between adjacent thymines in DNA leading to cyclobutane dimers (T<>Ts) and (6-4) adducts.

72 ential role for direct DNA damage, including cyclobutane dimers and (6-4) photoproducts, in the etiol

73 eases the quantum yield for the formation of cyclobutane dimers while reducing that of (6-4) adducts.

74 n contrast, cytosine within sunlight induced cyclobutane dipyrimidine dimers (CPD's), deaminate withi

75 ons has shed light on many of the details of cyclobutane-formation, in particular, for terpene natura

76 active approach to synthetically challenging cyclobutane frameworks under mild reaction conditions.

77 es, thus providing efficient access to fused cyclobutanes from easily accessed pi-components.

78 cted and highly stereoselective formation of cyclobutanes, functionalizing at the usually inert sites

79 in a tetracyclic norbornyl ketal leads to a cyclobutane-fused derivative as the major or exclusive p

80 Cyclobutane-fused dihydropyrans and methylenetetrahydrof

81 Thus, cyclobutane-fused dihydropyrans can be obtained by a sel

82 This strategy is demonstrated with a cyclobutane-fused lactone (CBL) polymer.

83 Several cyclobutane-fused O-heterocycles with diverse substituen

84 ting architecturally interesting, sp(3)-rich cyclobutane-fused scaffolds with potential applications

85 ve scission of the vinyl substituent of this cyclobutane gave an aldehyde, which was reacted with an

86 o form a diverse set of 1,1,3-trisubstituted cyclobutanes (>50 examples) with high diastereoselectivi

87 nal interpretation, the CC framework shields cyclobutane hydrogens, and its response to a perpendicul

88 action of these acyclic olefins to construct cyclobutanes in a highly regio- and diastereoselective m

89 s for the rapid synthesis of 1,3-substituted cyclobutanes in high yield under simple and robust react

90 1) the enantioselective preparation of a key cyclobutane intermediate by a tandem Wolff rearrangement

91 The beneficial role of a dominant cyclobutane intermediate in maintaining high stereoselec

92 ne beta-amide ester to form a donor-acceptor cyclobutane intermediate, which subsequently undergoes a

93 ous [2+2] alkene cycloaddition to synthesize cyclobutanes is kinetically accessible by photochemical

94 The cyclobutane keeps polymer backbone intact under conditio

95 Biosynthetic production of cyclobutanes leads to many complex natural products.

96 wo-dimensional (2D) polymers and crystalline cyclobutane-linked three-dimensional (3D) polymers.

97 Cyclobutane malonoyl peroxide (7), prepared in a single

98 report a molecular architecture, in which a cyclobutane mechanophore functions as a gate to regulate

99 The [2 + 2] cycloreversion of cyclobutane mechanophores has emerged as a versatile fra

100 mparing the relative reactivities of various cyclobutane mechanophores.

101 Calculations on cyclobutane, methylcyclobutane, and 1,1-dimethylcyclobut

102 one, the unique sesquiterpenoid containing a cyclobutane moiety of this class of compounds, has been

103 oumarin to generate a ternary cocrystal with cyclobutane molecules that support guest release.

104 rect synthesis of a representative norlignan cyclobutane natural product.

105 alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and

106 erformances of six stereo- and regioisomeric cyclobutane nitric ester materials are described.

107 ortion with an acetaldehyde appendage on the cyclobutane of the northern sector.

108 ch as bicyclo[1.1.1]pentanes, azetidines, or cyclobutanes often outweighs the challenge of synthesizi

109 ds involves the formation of an intermediate cyclobutane phodoadduct composed of (Br)U and U, which u

110 The cyclobutane photoproduct affords a novel diboron bis-twe

111 sing by valence isomerization of a precursor cyclobutane photoproduct with cis-syn stereochemistry th

112 The resultant cyclobutane product is functionalized with halogen atoms

113 astereomer of the resultant tetrasubstituted cyclobutane product via atomistic modeling of the CdSe s

114 The functionalized cyclobutane product was formed exclusively in high yield

115 benzene-d(6) produced predominantly the cis-cyclobutane product, establishing interconversion betwee

116 imolecular reductive elimination to form the cyclobutane product.

117 armaceutically relevant 1,1,3-trisubstituted cyclobutane products are decorated with an array of modu

118 diastereoselectivity in the formation of the cyclobutane products is excellent.

119 Functionalized cyclobutane products were obtained in excellent yields (

120 electivity but also delivered the respective cyclobutane products with significant enantiomeric exces

121 ereoselectivity for the previously minor syn-cyclobutane products.

122 provided access to simple alkyl substituted cyclobutane products.

123 ecular [2 + 2] alkene cycloadditions to form cyclobutanes promoted by ((tric)PDI)Fe(N(2)) ((tric)PDI

124 tion resulted in a decrease in the number of cyclobutane pyridimine dimer-positive APC that were foun

125 showed delayed repair of ultraviolet-induced cyclobutane pyrimidine adducts and elevated sensitivity

126 sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) formation.

127 sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) formation.

128 sites, which are also sites of preferential cyclobutane pyrimidine dimer (CPD) formation.

129 sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) formation.

130 ouble stranded oligonucleotides containing a cyclobutane pyrimidine dimer (CPD) lesion.

131 directly replicate through a leading-strand cyclobutane pyrimidine dimer (CPD) lesion.

132 PC orthologue Rad4 bound to DNA containing a cyclobutane pyrimidine dimer (CPD) lesion.

133 tors because of their incapability to repair cyclobutane pyrimidine dimer (CPD) lesions in duplex DNA

134 removed from the genome much faster than the cyclobutane pyrimidine dimer (CPD), owing to the more ef

135 constructs containing the UV-damaged adduct, cyclobutane pyrimidine dimer (CPD), to transfect human c

136 jor ultraviolet (UV)-induced DNA damage, the cyclobutane pyrimidine dimer (CPD), to two normal bases

137 We have developed a cyclobutane pyrimidine dimer (CPD)-specific immunoprecip

138 However, cyclobutane pyrimidine dimer accumulation was higher in

139 synthesis opposite the UV-induced DNA lesion cyclobutane pyrimidine dimer and was recently found to i

140 ions 7,8-dihydro-8-oxo-2'-deoxyguanosine and cyclobutane pyrimidine dimer but with rates that are 10(

141 ate or error-prone, as it is for bypass of a cyclobutane pyrimidine dimer by DNA polymerase eta (XP-V

142 The cyclobutane pyrimidine dimer class III photolyases are s

143 2, thereby facilitating DDB2 localization to cyclobutane pyrimidine dimer crosslinks to govern their

144 ruited at a reduced efficiency to UV-induced cyclobutane pyrimidine dimer foci.

145 The quantum yield of cyclobutane pyrimidine dimer formation was calculated as

146 Moreover, UV-induced cyclobutane pyrimidine dimer formation was markedly enha

147 photolyase, a photoenzyme, splits UV-induced cyclobutane pyrimidine dimer into two normal bases.

148 we demonstrate that a single, site-specific, cyclobutane pyrimidine dimer leading-strand template les

149 opposite strand preference is observed for a cyclobutane pyrimidine dimer lesion.

150 UVB-induced sunburn cells, 8-oxoguanine, and cyclobutane pyrimidine dimer lesions in skin of melanoma

151 ressing cells exhibit compromised removal of cyclobutane pyrimidine dimer lesions, a characteristic o

152 teins that bind to UV-damaged DNA containing cyclobutane pyrimidine dimer lesions.

153 coli replisome can directly bypass a single cyclobutane pyrimidine dimer or abasic site by translesi

154 ctrum and is capable of faithfully bypassing cyclobutane pyrimidine dimer photolesions.

155 ation via Cox-2 enzyme inhibition, increased cyclobutane pyrimidine dimer removal, and reduction of o

156 the Structure of Chromatin) and show greater cyclobutane pyrimidine dimer repair compared with unacet

157 mutated) activation, decreased efficiency in cyclobutane pyrimidine dimer repair, and elevated sensit

158 ns of PARP inhibitor, PJ-34, caused WT-level cyclobutane pyrimidine dimer repair.

159 ed in binding of the flavin cofactor and the cyclobutane pyrimidine dimer substrate, we report our di

160 Replication of a cyclobutane pyrimidine dimer was accurate, whereas repli

161 d into a DNA or RNA strand in proximity to a cyclobutane pyrimidine dimer, can mimic the function of

162 lesions, such as 8-oxo-2'-deoxyguanosine or cyclobutane pyrimidine dimer, even in the presence of an

163 ical fluorescein adducts, abasic sites nor a cyclobutane pyrimidine dimer, regardless of whether thes

164 When two rATPs were inserted opposite a cyclobutane pyrimidine dimer, the substrate was less eff

165 We used high-throughput sequencing of short, cyclobutane pyrimidine dimer-containing ssDNA oligos gen

166 rom these UV-induced linkages is the cis-syn cyclobutane pyrimidine dimer.

167 aryotic replisome following collision with a cyclobutane pyrimidine dimer.

168 Ultraviolet light induces cyclobutane pyrimidine dimers (CPD) and pyrimidine(6-4)p

169 ecies (ROS) as well as 6-4-photoproducts and cyclobutane pyrimidine dimers (CPD) in the skin, which f

170 I/SNF, negatively affects the elimination of cyclobutane pyrimidine dimers (CPD), but not of pyrimidi

171 measured repair of the UV-induced damage of cyclobutane pyrimidine dimers (CPDs) (at 1, 4, 8, 16, 24

172 d the number of epidermal cells positive for cyclobutane pyrimidine dimers (CPDs) 50% immediately pos

173 ent formation of photodimeric lesions, i.e., cyclobutane pyrimidine dimers (CPDs) and (6-4) photoprod

174 f two UV-induced DNA damages in human cells: cyclobutane pyrimidine dimers (CPDs) and (6-4) pyrimidin

175 PLs function predominantly in DNA repair of cyclobutane pyrimidine dimers (CPDs) and 6-4 photolesion

176 f DNA lesions per cell, mostly of two types: cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproduc

177 ing bulky base adducts, including UV-induced cyclobutane pyrimidine dimers (CPDs) and BaP diol epoxid

178 ght also introduce DNA damage in the form of cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4

179 nduced DNA damage that occurs in the form of cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyri

180 Damage maps of both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyri

181 Cyclobutane pyrimidine dimers (CPDs) are DNA photoproduc

182 ave ultraviolet (UVC) light not only produce cyclobutane pyrimidine dimers (CPDs) as reported but als

183 nown as CPD-seq, to precisely map UV-induced cyclobutane pyrimidine dimers (CPDs) at single-nucleotid

184 (UVB) light results in the formation of anti cyclobutane pyrimidine dimers (CPDs) between loop 1 and

185 utants exhibit enhanced repair of UV-induced cyclobutane pyrimidine dimers (CPDs) compared to wild-ty

186 Cyclobutane pyrimidine dimers (CPDs) constitute the most

187 amine the repair of ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPDs) in identical sequen

188 UV-induced cyclobutane pyrimidine dimers (CPDs) in the template DNA

189 radiation locally, DNA damage in the form of cyclobutane pyrimidine dimers (CPDs) was repaired more e

190 DNA lesions, such as cyclobutane pyrimidine dimers (CPDs), [6-4] pyrimidine-p

191 ix-distorting and bulky DNA lesions, such as cyclobutane pyrimidine dimers (CPDs), and DNA interstran

192 ions in sunlight-induced melanoma arise from cyclobutane pyrimidine dimers (CPDs), DNA photoproducts

193 promotes transcription bypass of UV-induced cyclobutane pyrimidine dimers (CPDs), increases survival

194 DNA glycosylases (pdgs) that initiate BER of cyclobutane pyrimidine dimers (CPDs), the predominant UV

195 ces a significant amount of abasic sites and cyclobutane pyrimidine dimers (CPDs).

196 e from translesion synthesis past deaminated cyclobutane pyrimidine dimers (CPDs).

197 more frequent than ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPDs).

198 by the increased detection of gammaH2AX and cyclobutane pyrimidine dimers 24 hours after UVB radiati

199 cells exhibited reduced repair of UV-induced cyclobutane pyrimidine dimers after PARP inhibition, sug

200 constructs and accelerated the resolution of cyclobutane pyrimidine dimers after UVL exposures in P38

201 that mutagenesis resulting from TLS opposite cyclobutane pyrimidine dimers and (6-4) photoproducts fo

202 critical for efficient removal of UV-induced cyclobutane pyrimidine dimers and (iii) p300 is recruite

203 e two major types of UVB-induced DNA damage, cyclobutane pyrimidine dimers and 6,4-photoproducts, by

204 d of malignancy-produces DNA lesions such as cyclobutane pyrimidine dimers and 6-4 photoproducts in s

205 P7 deficiency severely impairs the repair of cyclobutane pyrimidine dimers and, to a lesser extent, a

206 repair, bulky DNA lesions such as UV-induced cyclobutane pyrimidine dimers are removed from the genom

207 96A displayed a reduced repair efficiency of cyclobutane pyrimidine dimers as compared with cells com

208 s chc1 mutant showed similar accumulation of cyclobutane pyrimidine dimers as wild-type plants, in co

209 TT reduced the number of nuclei positive for cyclobutane pyrimidine dimers by 40% (P < 0.0002) and fo

210 dynamics or enhance the repair of UV-induced cyclobutane pyrimidine dimers by UV photolyase.

211 ar radiation is responsible for formation of cyclobutane pyrimidine dimers causing skin cancer.

212 hia coli uvrA, uvrB, and uvrC genes, removes cyclobutane pyrimidine dimers from the genome in a manne

213 ioned as a proto-flavin capable of repairing cyclobutane pyrimidine dimers in DNA or RNA by photoindu

214 ulations can be used to predict the yield of cyclobutane pyrimidine dimers in DNA.

215 ASA reduced UVB-induced 8-oxoguanine and cyclobutane pyrimidine dimers in Melan-A melanocytes and

216 e documented transcription-coupled repair of cyclobutane pyrimidine dimers in the ataxia telangiectas

217 appa in the extension reaction opposite from cyclobutane pyrimidine dimers in vivo.

218 rs and nucleosome-positioning DNA containing cyclobutane pyrimidine dimers or 6-4 photoproducts photo

219 UVR, no significant differences in epidermal cyclobutane pyrimidine dimers or sunburn cell (SBC) form

220 observed that MSH2 can facilitate TLS across cyclobutane pyrimidine dimers photoproducts in living ce

221 By 72 hours, 54 +/- 5% cyclobutane pyrimidine dimers remained in vehicle-fed ve

222 UVB-induced DNA damage (cyclobutane pyrimidine dimers) was resolved rapidly in G

223 free replication through ultraviolet-induced cyclobutane pyrimidine dimers, and inactivation of Polet

224 ne (2M) with the bipyrimidine models affords cyclobutane pyrimidine dimers, even in the presence of b

225 that it replicates past 5'T-T3' and 5'T-U3' cyclobutane pyrimidine dimers, incorporating G or T nucl

226 UVB readily induces cyclobutane pyrimidine dimers, mainly thymine dimers (TT

227 The frequency of all possible cyclobutane pyrimidine dimers, pyrimidine (6-4) pyrimido

228 UVB increased the repair rate of UVB-induced cyclobutane pyrimidine dimers, while inhibiting UVB-indu

229 on and NF-kappaB inhibition markedly reduced cyclobutane pyrimidine dimers-positive cells.

230 ght-induced DNA damage, faithfully bypassing cyclobutane pyrimidine dimers.

231 /-) mice had an increased resolution rate of cyclobutane pyrimidine dimers.

232 on-induced photoproducts in the DNA, such as cyclobutane pyrimidine dimers.

233 ced by a template carrying two site-specific cyclobutane pyrimidine dimers.

234 v) increased repair of 6-4 photoproducts and cyclobutane pyrimidine dimers.

235 6-4) pyrimidine-pyrimidone photoproducts and cyclobutane pyrimidine dimers.

236 DinB-1 works in an error-free mode to repair cyclobutane pyrimidine dimers.

237 at it is a bona fide photolyase that repairs cyclobutane pyrimidine dimers.

238 ess, and DNA damage such as 8-oxoguanine and cyclobutane pyrimidine dimers.

239 on of the most dangerous DNA lesions such as cyclobutane pyrimidine dimers.

240 overexpression qualitatively suppressed the cyclobutane pyrimidine removal defect associated with ME

241 resistance to repair of UVB-induced cis-syn cyclobutane pyrimidine-dimers (CPDs) together with rapid

242 aracterized intrastrand cross-links, such as cyclobutane pyrimidines dimers or cisplatin-DNA complex

243 One of the three stereoisomeric cyclobutanes reacts substantially more slowly than the o

244 clohexyl constitutional isomer 5 via a vinyl cyclobutane rearrangement.

245 ential escape routes was undertaken, through cyclobutane ring cleavage to 12-annulenes, sigmatropic 1

246 boxylic acid, a gamma-amino acid featuring a cyclobutane ring constraint, were prepared, and their co

247 etone, and (v) a radical cyclization for the cyclobutane ring formation to provide the tricyclo[5.2.1

248 SAR development around the cyclobutane ring resulted in a 10-fold increase in poten

249 tiated three electron transfer processes and cyclobutane ring splitting by following the entire dynam

250 The cyclobutane ring splitting takes tens of picoseconds, wh

251 l processes, electron-tunneling pathways and cyclobutane ring splitting, were not resolved.

252 h other molecules to form new materials, the cyclobutane ring was able to tolerate acid and base trea

253 (CPD), to two normal bases by splitting the cyclobutane ring.

254 biradical forms the final adduct featuring a cyclobutane ring.

255 Ladderanes consist of multiple fused cyclobutane rings and have recently been used as monomer

256 Cyclobutane rings are important in medicinal chemistry,

257 olecules for their unique structure of fused cyclobutane rings as well as their perceived biological

258 According to the X-ray data the cyclobutane rings in both compounds are almost planar (t

259 The formation of cyclobutane rings is a promising strategy in the develop

260 rbons containing unsaturatively, 1,3-bridged cyclobutane rings, (2) the use of orbital topology for p

261 C(2h) symmetry composed of five edge-sharing cyclobutane rings, or a [5]-ladderane, with acid results

262 action that results in a photodimer with two cyclobutane rings.

263 the anthracene rings precedes rupture of the cyclobutane rings.

264 eses of small libraries of trifunctionalized cyclobutane scaffolds bearing an acid, an amine, and a t

265 polymer to generate a pyridyl-functionalized cyclobutane stereoselectively and in quantitative yield.

266 e of unsymmetrical tri- and tetrasubstituted cyclobutane structures can be produced in good yields an

267 st for the preparation of sterically crowded cyclobutane structures is highlighted through the prepar

268 heterocoupling, a major challenge in direct cyclobutane synthesis.

269 is more than 8 kcal mol-1 less strained than cyclobutane, that is, there is at least some thermodynam

270 y employed for the synthesis of oxetanes and cyclobutanes, the synthesis of azetidines via intermolec

271 iciently synthesized from a mono-substituted cyclobutane through sequential C-H arylation reactions,

272 form unsymmetrical tri- and tetrasubstituted cyclobutanes through a heterodimerization process involv

273 synthesis across a template abasic site or a cyclobutane thymidine dimer.

274 horizontal lineC/C-C stretch vibrations) of cyclobutane thymine dimer and thymine dinucleotide radic

275 Cyclobutane thymine dimer, one of the major lesions in D

276 Dpo2 and Dpo3 bypassed uracil and cis-syn cyclobutane thymine dimer, respectively.

277 , 8-oxoguanine, and either uracil or cis-syn cyclobutane thymine dimer, suggesting their catalyticall

278 m light indicates that the photoproduct is a cyclobutane thymine dimer.

279 ion synthesis (TLS) of site-specific cis-syn cyclobutane thymine dimers (T (wedge)T).

280 Cyclobutane thymine dimers (T-T) comprise the majority o

281 es to extend synthetic primers past template cyclobutane thymine dimers (T[CPD]T) or undamaged T-T un

282 This value is comparable to that of cyclobutane thymine dimers (the major UV-induced lesions

283 The formation of cyclobutane thymine dimers is one of the most important

284 common DNA lesions, such as abasic sites and cyclobutane thymine dimers.

285 e steps during DNA synthesis through cis-syn cyclobutane thymine dimers.

286 rotective role against skin cancer caused by cyclobutane thymine-thymine dimers (TTDs), a frequent fo

287 uch as bicyclo[1.1.1]pentane, azetidine, and cyclobutane to modify their lead compounds.

288 s the rapid and stereoselective formation of cyclobutanes under very mild reaction conditions.

289 The resultant cyclobutane undergoes spontaneous retro-Mannich fission

290 triflates and organoboronic esters across a cyclobutane unit with total diastereocontrol.

291 rategy for the construction of unsymmetrical cyclobutanes using C-H functionalization logic is demons

292 stly lower strain energy (1.8 kcal/mol) of a cyclobutane versus a cyclopropane.

293 f the incorporation of a ring-expanded fused cyclobutane (vs cyclopropane), its chemical and structur

294 A chiral trisubstituted cyclobutane was efficiently synthesized from a mono-subs

295 ne providencin containing a tetrasubstituted cyclobutane was synthesized from the bis(acetonide) of d

296 onor-acceptor cyclopropanes or corresponding cyclobutanes were treated with 1,3,5-triazinanes, leadin

297 rivatives, is a unique strategy to construct cyclobutanes, which are building blocks for a variety of

298 n, the nonoptimal geometric alignment of the cyclobutane with the activating cyclohexadienone, and th

299 nocatalysis allowing for the construction of cyclobutanes with four contiguous stereocenters with com

300 ping sequence to give densely functionalized cyclobutanes with high diastereoselectivity.