ライフサイエンスコーパス: cyclohexanone

1 (O)O(-)) along with ketones (acetophenone or cyclohexanone).

2 smoke irritants (acrolein, acetic acid, and cyclohexanone).

3 ing its precursor, epsilon-caprolactam, from cyclohexanone.

4 with inexpensive and commercially available cyclohexanone.

5 t mechanism for the enzymatic oxygenation of cyclohexanone.

6 intermediate could oxygenate the substrate, cyclohexanone.

7 the enzymes responsible for the oxidation of cyclohexanone.

8 benzoate derivative at the 3-position of the cyclohexanone.

9 electrochemical Baeyer-Villiger oxidation of cyclohexanone.

10 , with >90% selectivity to more bioavailable cyclohexanone.

11 -H = 6.91 Hz is nearly double those found in cyclohexanone.

12 ypical solvent for membrane preparation) and cyclohexanone.

13 r, in 27% (7 steps) for the (R)-isomer, from cyclohexanone.

14 epine starting from 2-((1H-indol-3-yl)methyl)cyclohexanone.

15 tion was more complex for 3-akyl-substituted cyclohexanones.

16 ze of the substituents at C-2 and C-4 of the cyclohexanones.

17 ss of the substituents at C-2 and C-4 of the cyclohexanones.

18 ed to oxidize 15 different alkyl-substituted cyclohexanones.

19 reocontrol in ring expansions of symmetrical cyclohexanones.

20 d desymmetrization of vinyl-bromide-tethered cyclohexanones.

21 uctural variety of fused cyclopentanones and cyclohexanones.

22 C-C bonds in simple cyclopentanones and some cyclohexanones.

23 sis cyclize efficiently to the corresponding cyclohexanones.

24 s was explored for the elaboration of chiral cyclohexanones.

25 cyclopentanone, 2,6-bis(4-amidinobenzylidene)cyclohexanone, 2,7-bis(4-amidinobenzylidene)cycloheptano

26 tic approach starting from readily available cyclohexanone 3.

27 ic alcohol 35, while 19 provided ring-opened cyclohexanone 41 (39%) along with the tricyclic epoxide

28 ed from unraveling of the tetracyclic system cyclohexanone 46.

29 The carbonyl deprotection in 22 yielded cyclohexanone 5 that was subjected to Julia coupling wit

30 The known cyclohexanone 5 was converted in five steps to the alpha

31 dol addition of a silyloxyfuran to a complex cyclohexanone 83 appended the butenolide, and a few addi

32 selective detection of cyclic ketones, e.g. cyclohexanone, a component of plasticized explosives.

33 d sensitive gas sensor to selectively detect cyclohexanone, a target analyte for explosive detection.

34 ovides functionalized alpha-(hetero)arylated cyclohexanones, a scaffold present in many natural produ

35 a ring-expansion reaction of a 4-substituted cyclohexanone accomplished with a chiral 1,3-azidopropan

36 ilic substitution reactions of 4-substituted cyclohexanone acetals display different selectivities de

37 The reactions of cyclohexanone acetals substituted with thiophenyl groups

38 The dehydrogenation of cyclohexanones affords cyclohexenones or phenols via rem

39 ted irritation responses to acetic acid, and cyclohexanone, an agonist of the capsaicin receptor, TRP

40 Novel 2,6-bis benzylidine cyclohexanone analogues of curcumin were synthesized, an

41 series of cycloalkanone rings, 4-substituted cyclohexanone analogues, and modified amidine derivative

42 We tested the hydroxylation of cyclohexanone and 1-acetyladamantane under different oxi

43 a highly efficient host for the inclusion of cyclohexanone and 2-, 3-, and 4-methylcyclohexanone, all

44 d to catalyze a model aldol reaction between cyclohexanone and 4-nitrobenzaldehyde, but it did not ma

45 ble responses in less than 30 s to 10 ppm of cyclohexanone and displayed an average theoretical limit

46 ric Schmidt reaction between 4-disubstituted-cyclohexanone and hydroxyalkylazides, 1H-azepine-2-oxo-5

47 trolling TS for the Michael reaction between cyclohexanone and nitrostyrene is proposed.

48 14 times more active in the condensation of cyclohexanone and phenol to bisphenol Z.

49 iacetal, which then undergoes elimination to cyclohexanone and phenol/alkanol products.

50 nally biased imines derived from substituted cyclohexanones and benzylamine or diphenylmethylamine, r

51 investigation of aerobic dehydrogenation of cyclohexanones and cyclohexenones to phenols with a Pd(T

52 as a catalyst for direct dehydrogenation of cyclohexanones and other cyclic ketones to the correspon

53 The cyclohexanones and the title compounds showed a strong t

54 carbon dioxide, isoprene, acetone, benzene, cyclohexanone, and 4 thioethers.

55 Reactions of 1a with cyclopentanone, cyclohexanone, and cyclooctanone enolates afforded new t

56 ze lithium enolates derived from 1-indanone, cyclohexanone, and cyclopentanone in solution.

57 henyl-4-[3-(methoxyphenyl)-3-oxo-2-azapropyl]cyclohexanone, and our own compound Psora-4 inhibit the

58 decomposition of cyclohexyl hydroperoxide to cyclohexanone, and the asymmetric amination of ketones w

59 ial nucleophilic methylation of a late-stage cyclohexanone, and the first selective synthesis and ant

60 chemicals (e.g., ammonia, hydrogen peroxide, cyclohexanone, and water) at part-per-thousand and part-

61 Additions to cyclohexanone are relatively slow but form a single isom

62 Functionalized cyclohexanones are formed in excellent yield and diaster

63 Given that functionalized cyclohexanones are readily accessible with complete regi

64 Using 2,2-dimethyl cyclohexanone as the starting compound, (+)-antrocin and

65 nstruction of anilines, exploiting saturated cyclohexanones as aryl electrophile surrogates.

66 cess to highly substituted alpha-spirocyclic cyclohexanones as well as cyclopentanones.

67 cus sp. HI-31 in complex with its substrate, cyclohexanone, as well as NADP(+) and FAD, to 2.4 A reso

68 A new procedure for the synthesis of cyclohexanone-based inhibitors of serine proteases is re

69 Compounds 1, 3, and 5 were cyclohexanone-based inhibitors, whereas compounds 2, 4,

70 tive phenol dearomatization affords complex, cyclohexanone-based scaffolds from simple starting mater

71 th 2,6-Bis-(3-methoxy-4-propoxy-benzylidene)-cyclohexanone (BM2) was 17 times more toxic than curcumi

72 d annulation strategy for the fabrication of cyclohexanone-bridged indazolones and other related diaz

73 Higher levels of hexane, styrene, cyclohexanone, butylated hydroxytoluene and 2-butoxyetha

74 Then, the biofilm mineralized the cyclohexanone by utilizing it as a supplementary electro

75 ho methoxyphenol was rapidly bioreduced to a cyclohexanone cis-diol.

76 d to inhibitors that are based upon a simple cyclohexanone core.

77 achieved in the oxidation of cyclohexane to cyclohexanone/cyclohexanol (100 degrees C, conversion: 1

78 -fluorophenolate and the lithium enolates of cyclohexanone, cyclopentanone and 4-fluoroacetophenone h

79 Pd-MBfR enriched the microbial community in cyclohexanone degraders within Clostridium, Chryseobacte

80 The SEs of cyclohexanone, delta-valerolactone, and delta-valerolact

81 ia coupling of sulfones 39a and 39b with the cyclohexanone derivative 23.

82 -Brook rearrangement of an easily accessible cyclohexanone derivative, followed by triflation protoco

83 ved in this process takes place with several cyclohexanone derivatives and 2-aminoaromatic aldehydes,

84 substrates, and the corresponding nonracemic cyclohexanone derivatives containing an all-carbon quate

85 y for the synthesis of highly functionalized cyclohexanone derivatives containing an all-carbon quate

86 either by peroxidation of the corresponding cyclohexanone derivatives in H(2)SO(4)/CH(3)CN or by ozo

87 ilable via the peroxidation of corresponding cyclohexanone derivatives in H2SO4/CH3CN.

88 e with an aldehyde provides pentasubstituted cyclohexanone derivatives in which the annulation reacti

89 y amine organocatalyst, a range of prochiral cyclohexanone derivatives possessing an alpha,beta-unsat

90 selectively dehydrogenate the 3-substituted cyclohexanone derivatives to form the alpha,beta-unsatur

91 In this study, we explored benzylidine cyclohexanone derivatives with non-polar groups, to see

92 of tetralone, indanone, cyclopentanone, and cyclohexanone derivatives.

93 Cyclohexanone-derived Knoevenagel adducts (cyclohexylide

94 ed axial attack of the carbonyl oxide on the cyclohexanone dipolarophiles.

95 gh the cyclization of a suitably substituted cyclohexanone enol ether or enol silane with malonyl dic

96 is was also true for the 2-alkyl-substituted cyclohexanones examined.

97 talyzed desymmetrization of 4-propargylamino cyclohexanones for the direct enantioselective synthesis

98 romoted formal [4+2] annulation proceeds via cyclohexanone formation and involves the cascade transfo

99 is relies on stereoselective fashioning of a cyclohexanone framework and double conjugate addition of

100 bonds to access unexpected C8-chalcogenated cyclohexanone-fused 4-hydroxy-2-pyridones in very good y

101 a-1,3-dione and cyanoacetic acid to generate cyclohexanone-fused 4-hydroxy-2-pyridones that undergo I

102 Cyclohexanones give products arising from equatorial att

103 s of tertiary alpha-aryl cyclopentanones and cyclohexanones has been accomplished via a Pd-catalyzed

104 amic kinetic resolution of alpha-substituted cyclohexanones has been performed and yields versatile i

105 alyze the transfer hydrogenation reaction of cyclohexanone in a 2-butanol solvent 10x faster than the

106 tabolic genes involved in the degradation of cyclohexanone in a new halotolerant Brevibacterium envir

107 the hydrogen-deuterium exchange reaction of cyclohexanone in aqueous solution, as catalyzed by proli

108 al standard in a mixture of ethylbenzene and cyclohexanone in hexane with analyte quantities of < 3 n

109 low reactivity of alicyclic ketones such as cyclohexanone in reactions with triflic anhydride and al

110 provide a range of alpha,beta-disubstituted cyclohexanones in high yield although the products are p

111 The role of twist-boat conformers of cyclohexanones in hydride reductions was explored.

112 -diacetal protection to produce a key chiral cyclohexanone intermediate, from which all five carbasug

113 oxidation of cyclohexane to cyclohexanol and cyclohexanone is used as a model reaction to investigate

114 Further functionalization of the cyclohexanones is achieved without perturbation of stere

115 f the Ruppert-Prakash reagent to substituted cyclohexanones is presented.

116 trolled approach to alpha-alkyl beta-alkynyl cyclohexanones is reported through a Lewis acid mediated

117 Instead, the substrate, cyclohexanone, is found at this location, in an appropri

118 The N-isopropylimine of cyclohexanone lithiates via an ensemble of monomer-based

119 H(3)CN or by ozonolysis of the corresponding cyclohexanone methyl oximes.

120 ing an embedded tetrahydrofuran in which the cyclohexanone moiety was converted to a triisopropylsily

121 eport the first crystal structure of a BVMO, cyclohexanone monooxygenase (CHMO) from Rhodococcus sp.

122 Cyclohexanone monooxygenase (CHMO), a bacterial flavoenz

123 ymatic Baeyer-Villiger reaction catalyzed by cyclohexanone monooxygenase (CHMO).

124 , which is different from the specificity of cyclohexanone monooxygenase favoring short-chain cyclic

125 ich each newly cloned enzyme, as well as the cyclohexanone monooxygenase from Acinetobacter sp. NCIB

126 Whereas one ORF showed high homology to cyclohexanone monooxygenase from Acinetobacter sp. strai

127 ssing either cyclopentanone monooxygenase or cyclohexanone monooxygenase was immobilised in the form

128 Homologues of an acetone/cyclohexanone monooxygenase were identified in the HTCC1

129 s, including phenylacetone monooxygenase and cyclohexanone monooxygenase.

130 identification of the genes of two distinct cyclohexanone monooxygenases, the enzymes responsible fo

131 nd the structure and reactivity of lithiated cyclohexanone N-cyclohexylimine.

132 N-(isopropanesulfinyl)ketimines derived from cyclohexanone, N-Boc-piperidin-4-one, and tetrahydropyra

133 The inhibitors are based upon a cyclohexanone nucleus and are designed to probe binding

134 Ethylbenzene and cyclohexanone of a single D enrichment are analyzed as u

135 potency of inhibitors that are based upon a cyclohexanone or a tetrahydro-4H-thiopyran-4-one 1,1-dio

136 Bis-cyclohexanone oxalyldihydrazone (cuprizone) was administ

137 a strategy based only on the knowledge that cyclohexanone oxidation was inducible in this strain, th

138 arginally similar to the analogous genes for cyclohexanone oxidation.

139 de assembly of 4,5,6,7-tetrahydroindole from cyclohexanone oxime and acetylene.

140 an be generated in situ as needed, producing cyclohexanone oxime with >95% selectivity, comparable to

141 Oxidation of cyclohexanone oxime with lead tetraacetate yields 1-nitr

142 is currently applied commercially to produce cyclohexanone oxime, an important feedstock in nylon-6 p

143 -4-[3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl]cyclohexanone (PAC), which is representative of a disubs

144 pproach for phenol synthesis using saturated cyclohexanone precursors.

145 s starting with a multicomponent reaction of cyclohexanone, primary amine and N-tosyl-3-nitroindole f

146 The cyclohexanone products are obtained in excellent diaster

147 re reduced to isotetralin (74%) and 3-methyl cyclohexanone (quantitative) with 5 and 2.2 Li/mol of st

148 f the "ene"-reductase nicotinamide-dependent cyclohexanone reductase (NCR) from Zymomonas mobiles cap

149 rd cyclobutanols are largely lacking, unlike cyclohexanone reductions.

150 alpha-lithiation of the N-isopropylimine of cyclohexanone reveal monomer-based transition structures

151 ithiations of N-alkyl ketimines derived from cyclohexanones reveal that simple substitutions on the N

152 ethyl 2-adamantanone oxime and 4-substituted cyclohexanones reveals that the major tetrasubstituted o

153 dole alkaloid possessing a fully substituted cyclohexanone ring system with two quaternary carbons, h

154 ring an additional alpha-substitution on the cyclohexanone ring was then epimerized into its thermody

155 ss of the substituents at C-2 and C-4 of the cyclohexanone ring.

156 dicted stereoselectivity of the reduction of cyclohexanone strongly favors axial approach of hydrogen

157 74% ee were achieved for cyclopentanone and cyclohexanone substrates, respectively.

158 lations on the starting electrophile 2-aroyl-cyclohexanone support a correlation between the energy o

159 For all 4-alkyl-substituted cyclohexanones tested, enzymes were discovered that affo

160 e the QM region consisting of the substrate (cyclohexanone), the isoalloxazine ring of C4a-peroxyflav

161 talyst mediates the first dehydrogenation of cyclohexanone to cyclohexenone, after which it evolves i

162 ate of Pd(TFA)2-catalyzed dehydrogenation of cyclohexanone to cyclohexenone, while it strongly inhibi

163 idic and redox sites, which smoothly convert cyclohexanone to epsilon-caprolactam with selectivities

164 carries out an oxygen insertion reaction on cyclohexanone to form a seven-membered cyclic product, e

165 ion of NADPH and a two-electron oxidation of cyclohexanone to form epsilon-caprolactone.

166 In the course of these studies, the Kd for cyclohexanone to the C4a-peroxyflavin form of CHMO was d

167 ing reaction of various brominated PAHs with cyclohexanone to yield alpha-arylated ketones, which are

168 high chemoselectivity for the conversion of cyclohexanones to cyclohexenones, without promoting subs

169 asymmetric fluorination of alpha-substituted cyclohexanones to generate quaternary fluorine-containin

170 ne ligand, for the conversion of substituted cyclohexanones to the corresponding phenols.

171 Rate studies of addition to cyclohexanone trace the lack of aggregation-dependent se

172 ors with the general structure Cbz-X(aa)-Trp-cyclohexanone-Trp-Y(aa)-OH has been constructed.

173 ymmetric Michael addition of nitromethane to cyclohexanone (up to 96.5:3.5 er) surpassing epi-aminoqu

174 The ammoximation of cyclohexanone using preformed hydrogen peroxide (H(2)O(2

175 ith cofacial pi-pi interactions, it binds to cyclohexanone via hydrogen bond (mechanistic studies wer

176 pplied to the asymmetric synthesis of chiral cyclohexanones via a catalytic [4+2] cycloaddition.

177 ain, the mRNA population of cells exposed to cyclohexanone was compared to that of control cells usin

178 ssociated with obesity, and higher levels of cyclohexanone were associated with increased child BMI.

179 responding to axial and equatorial attack at cyclohexanone were located.

180 thium aluminum hydride with formaldehyde and cyclohexanone were obtained using ab initio and density

181 Calculations of geometries of the guest cyclohexanones were determined at the MP2/6-311++G(2df,2

182 d enantiomerically enriched 2-methyl 3-allyl cyclohexanone, which engaged in acid-catalyzed Robinson

183 sis, yielded the corresponding 4-(arylmethyl)cyclohexanones, which were then condensed with cyanoguan

184 The mechanism of the oxidation of cyclohexanone with an aqueous solution of hydrogen perox

185 x reactions involving the aldol reactions of cyclohexanone with benzaldehyde or with isobutyraldehyde

186 on of prochiral ketones of type 4-alkylidene cyclohexanone with formation of the corresponding axiall

187 Aldol additions to isobutyraldehyde and cyclohexanone with lithium enolates derived from acylate

188 The reaction of 2-aroyl-cyclohexanones with 2-cyanoacetamide and base in ethanol

189 le to promote the direct reaction of various cyclohexanones with dibenzoyl peroxide, thus affording t

190 stems that effect aerobic dehydrogenation of cyclohexanones with different product selectivities.

191 This process delivers functionalized cyclohexanones with good to excellent levels of diastere

192 talyzed Wittig olefinations of 4-substituted cyclohexanones with non-stabilized phosphorus ylides to

193 catalytic desymmetrization of 4-substituted cyclohexanones with O-arylhydroxylamines and is catalyze

194 examethylene triperoxide diamine (HMTD), and cyclohexanone, with detection limits in the parts-per-tr

195 A series of 2-aroyl-cyclohexanones, with para-substituents ranging from elec